RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Antihypertensive treatment with β-blockade in patients with asymptomatic aortic stenosis and association with cardiovascular events
Vise andre og tillknytning
2017 (engelsk)Inngår i: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, ISSN 2047-9980, E-ISSN 2047-9980, Vol. 6, nr 12, artikkel-id e006709Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Patients with aortic stenosis (AS) often have concomitant hypertension. Antihypertensive treatment with a beta-blocker (Bbl) is frequently avoided because of fear of depression of left ventricular function. However, it remains unclear whether antihypertensive treatment with a Bbl is associated with increased risk of cardiovascular events in patients with asymptomatic mild to moderate AS.

Methods and results: We did a post hoc analysis of 1873 asymptomatic patients with mild to moderate AS and preserved left ventricular ejection fraction in the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) study. Propensity-matched Cox regression and competing risk analyses were used to assess risk ratios for all-cause mortality, sudden cardiac death, and cardiovascular death. A total of 932 (50%) patients received Bbl at baseline. During a median follow-up of 4.3 +/- 0.9 years, 545 underwent aortic valve replacement, and 205 died; of those, 101 were cardiovascular deaths, including 40 sudden cardiovascular deaths. In adjusted analyses, Bbl use was associated with lower risk of all-cause mortality (hazard ratio 0.5, 95% confidence interval 0.3-0.7, P<0.001), cardiovascular death (hazard ratio 0.4, 95% confidence interval 0.2-0.7, P<0.001), and sudden cardiac death (hazard ratio 0.2, 95% confidence interval 0.1-0.6, P=0.004). This was confirmed in competing risk analyses (all P<0.004). No interaction was detected with AS severity (all P>0.1).

Conclusions: In post hoc analyses Bbl therapy did not increase the risk of all-cause mortality, sudden cardiac death, or cardiovascular death in patients with asymptomatic mild to moderate AS. A prospective study may be warranted to determine if Bbl therapy is in fact beneficial.

sted, utgiver, år, opplag, sider
Wiley-Blackwell Publishing Inc., 2017. Vol. 6, nr 12, artikkel-id e006709
Emneord [en]
aortic valve stenosis, arrhythmia (heart rhythm disorders), atrial fibrillation, beta-blocker, high blood essure, hypertension
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-144421DOI: 10.1161/JAHA.117.006709ISI: 000418951100020OAI: oai:DiVA.org:umu-144421DiVA, id: diva2:1181386
Tilgjengelig fra: 2018-02-08 Laget: 2018-02-08 Sist oppdatert: 2018-06-09bibliografisk kontrollert

Open Access i DiVA

fulltext(943 kB)31 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 943 kBChecksum SHA-512
4898b64117f7a5d2c7abd253d1805560b4c67d4e88963882237e555ef6c8211378f1f82c64a83e3b6aa4c7f33af16ea803e3df9e4fd8e9fb679d8a3111747c39
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekst

Søk i DiVA

Av forfatter/redaktør
Boman, Kurt
Av organisasjonen
I samme tidsskrift
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 31 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 41 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf