Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Synthesis and Characterization of Acrylfentanyl Metabolites
Linköpings universitet, Institutionen för fysik, kemi och biologi, Kemi.
2017 (engelsk)Independent thesis Basic level (degree of Bachelor), 10,5 poäng / 16 hpOppgave
Abstract [en]

Acrylfentanyl is a synthetic opioid that has been widely used in the last year. To help in the fight against synthetic drugs two potential metabolites of acrylfentanyl, one monohydroxy and one dihydroxy were synthesized. These metabolites will hopefully later be implemented in the analytical methods for metabolites of acrylfentanyl in urine by the Swedish National Board of Forensic Medicine.

To have metabolites for analysis are very important as they are the main target in drug testing.

The method used to synthesize the metabolites is a five-step synthesis with an additional 6th step for the dihydroxy metabolite. The methods used in the synthesis includes protection of amine with tert-butyloxycarbonyl, reductive amination with sodium triaceto boronhydride, alkylation and demethylation with boron tribromide. The methods used produced good results with high yields in nearly all steps.

sted, utgiver, år, opplag, sider
2017. , s. 20
Emneord [en]
Acrylfentanyl, Metabolite, Synthesis
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-138142ISRN: LiTH-IFM-G-EX--17/3321--SEOAI: oai:DiVA.org:liu-138142DiVA: diva2:1109572
Fag / kurs
Chemistry
Presentation
2017-05-31, Linköping, 14:20 (engelsk)
Veileder
Examiner
Tilgjengelig fra: 2017-06-19 Laget: 2017-06-14 Sist oppdatert: 2017-06-19bibliografisk kontrollert

Open Access i DiVA

Synthesis and Characterization of Acrylfentanyl Metabolites(1113 kB)119 nedlastinger
Filinformasjon
Fil FULLTEXT02.pdfFilstørrelse 1113 kBChecksum SHA-512
d7ad399f0dbc30d43af24c9b6d4532dd5bd15adf6b845808f8188fe32a39fba56638e09d63920e08efeba0924ed825e17df5a5b01c7e1c94cd0e713568cb4399
Type fulltextMimetype application/pdf

Søk i DiVA

Av forfatter/redaktør
Alfredsson, Maria
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 119 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

urn-nbn

Altmetric

urn-nbn
Totalt: 144 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf