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The Placental Immune Milieu is Characterized by a Th2- and Anti-Inflammatory Transcription Profile, Regardless of Maternal Allergy, and Associates with Neonatal Immunity
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
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2015 (English)In: American Journal of Reproductive Immunology, ISSN 1046-7408, E-ISSN 1600-0897, Vol. 73, no 5, 445-459 p.Article in journal (Refereed) Published
Abstract [en]

PROBLEM: How maternal allergy affects the systemic and local immunological environment during pregnancy and the immune development of the offspring is unclear.

METHOD OF STUDY: Expression of 40 genes was quantified by PCR arrays in placenta, peripheral blood mononuclear cells (PBMC), and cord blood mononuclear cells (CBMC) from 7 allergic and 12 non-allergic women and their offspring.

RESULTS: Placental gene expression was dominated by a Th2-/anti-inflammatory profile, irrespectively of maternal allergy, as compared to gene expression in PBMC. p35 expression in placenta correlated with fetal Tbx21 (ρ = -0.88, P < 0.001) and IL-5 expression in PBMC with fetal galectin1 (ρ = 0.91, P < 0.001). Increased expression of Th2-associated CCL22 in CBMC preceded allergy development.

CONCLUSIONS: Gene expression locally and systemically during pregnancy was partly associated with the offspring's gene expression, possibly indicating that the immunological milieu is important for fetal immune development. Maternal allergy was not associated with an enhanced Th2 immunity in placenta or PBMC, while a marked prenatal Th2 skewing, shown as increased CCL22 mRNA expression, might contribute to postnatal allergy development.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2015. Vol. 73, no 5, 445-459 p.
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Clinical Medicine Cell and Molecular Biology Immunology in the medical area
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URN: urn:nbn:se:liu:diva-114069DOI: 10.1111/aji.12350ISI: 000352810200007PubMedID: 25491384OAI: oai:DiVA.org:liu-114069DiVA: diva2:786802
Available from: 2015-02-06 Created: 2015-02-06 Last updated: 2016-04-24

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Abelius, Martina SJanefjord, CamillaErnerudh, JanBerg, GöranMatthiesen, LeifDuchén, KarelNilsson, Lennart JJenmalm, Maria
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDivision of Cell BiologyDepartment of Clinical Immunology and Transfusion MedicineDivision of Clinical SciencesDepartment of Gynaecology and Obstetrics in LinköpingDepartment of Paediatrics in LinköpingAllergy Center
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