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The Role of Antibiotic Therapy in the Management of Acute Appendicitis
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Cty Hosp Ryhov, Sweden.
2013 (English)In: Current Infectious Disease Reports, ISSN 1523-3847, E-ISSN 1534-3146, Vol. 15, no 1, 10-13 p.Article in journal (Refereed) Published
Abstract [en]

Nonsurgical treatment with antibiotics has recently been proposed as the first line of treatment for noncomplicated appendicitis. This has met with considerable interest, illustrated by the number of reviews and meta-analyses, which exceed the number of original reports of the issue. The results in these studies are seriously biased due to inclusion of patients with resolving appendicitis. At a time when we need to reduce inappropriate use of antibiotics in the struggle against the increasing rate of antibiotics resistance, there must be strong requirements of a proven effect and an improved cost-benefit ratio before antibiotics treatment is introduced for a new group of patients. These requirements have not yet been met for nonsurgical treatment with antibiotics for assumed uncomplicated appendicitis. Due to the high rate of spontaneous resolution, a randomized placebo-controlled trial is needed that can compare the efficiency of antibiotics treatment and expectant management in this group of patients. Antibiotics treatment, however, remains indicated for treatment of perforated appendicitis with localized abscess or phlegmone and in selected surgical high-risk patients.

Place, publisher, year, edition, pages
Current Medicine Group , 2013. Vol. 15, no 1, 10-13 p.
Keyword [en]
Antibiotic therapy; Acute appendicitis management; Abscess and phlegmone; Uncomplicated appendicitis
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-109954DOI: 10.1007/s11908-012-0303-3ISI: 000338285600003PubMedID: 23188622OAI: oai:DiVA.org:liu-109954DiVA: diva2:741894
Available from: 2014-08-29 Created: 2014-08-29 Last updated: 2014-11-26

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