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Aspects on stroke outcome: survival, functional status, depression and sex differences in Riks-Stroke, the National Quality Register for Stroke Care
Umeå University, Faculty of Medicine, Public Health and Clinical Medicine.
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Stroke is a major cause of death and disability worldwide. In Sweden, about 30 000 strokes occur each year. The aim of this thesis was to analyse survival, functional outcome and self-reported depression after stroke, and to explore possible differences between men and women in stroke care and outcome.

These studies were based on Riks-Stroke, the Swedish national quality register for stroke care. Information on background variables and treatment were collected during the hospital stay. The patient’s situation and outcome after stroke were followed-up after 3 months. Long term survival was retrieved from the Swedish Population Register (Folkbokföringen).

Possible sex-differences in stroke care and outcome 3 months after stroke were explored in 24 633 strokes, registered during 2006. In conscious patients, the proportions treated at stroke units were similar for men and women. Men and women had equal chance to receive thrombolytic therapy or secondary prevention with oral anticoagulants. Compared to men, women were less likely to develop pneumonia, but more likely to experience deep venous thromboses and fractures during hospital stay. Women had worse 3-month survival and functional outcome, differences that were explained by their higher age and impaired level of consciousness on admission. Women felt more depressed and perceived their health as worse than men did. Women were also less satisfied with the care they had received in the hospital.

The agreement between self-reported functional outcome 3 months after stroke and the commonly used modified Rankin Scale (mRS) was explored in 555 stroke survivors from 4 hospitals during May-September 2005. Riks-Stroke’s self-reported questions classified 76% of the patients into correct mRS grade.

The association between functional outcome 3 months after stroke and 3-year survival was assessed in 15 959 men and women who had had a stroke during 2001-2002. Patients with estimated mRS grades 3, 4 and 5 had hazard ratios for death of 1.7, 2.5 and 3.8, respectively, as compared with patients with lower grades, 0-2. Depressed mood, male sex, high age, diabetes, smoking, antihypertensive therapy at onset and atrial fibrillation were also identified as predictors of poor survival.

Self-reported depression 3 months after stroke and use of antidepressants were analysed in 15 747 stroke survivors from 2002. Fourteen percent felt depressed 3 months after stroke. Female sex, age <65, previous stroke, living alone or in institution, or being dependent in activities of daily living (ADL) were factors associated with self-reported depression. At the follow-up, 22% of the men and 28% of the women were using antidepressant medication, which were approximately twice as many as in the general population. Still, 8% of all patients in Riks-Stroke reported depressive mood but no treatment with antidepressants.

In conclusion, men and women with stroke in Sweden experience similar treatment and outcome in most aspects. Patient-reported functional outcome can be reliably transformed to a standard disability scale. Impaired functional outcome three months after stroke is an independent predictor of poor long-term survival. Depressive mood is common after stroke and is associated with poor survival and impaired functional outcome.

Place, publisher, year, edition, pages
Umeå: Folkhälsa och klinisk medicin , 2008. , 53 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 1171
Keyword [en]
stroke, stroke outcome, registry, sex differences, case fatality, functional recovery, depression
National Category
Clinical Science
Identifiers
URN: urn:nbn:se:umu:diva-1649ISBN: 987-91-7264-546-2 OAI: oai:DiVA.org:umu-1649DiVA: diva2:141697
Public defence
2008-06-13, Sal B, Tandläkarhögskolan, 9tr, Norrlands Universitetssjukhus, Umeå, 09:00 (English)
Opponent
Supervisors
Available from: 2008-05-13 Created: 2008-05-13 Last updated: 2010-01-18Bibliographically approved
List of papers
1. Sex differences in stroke care and outcome in the Swedish national quality register for stroke care
Open this publication in new window or tab >>Sex differences in stroke care and outcome in the Swedish national quality register for stroke care
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Manuscript (Other academic)
Identifiers
urn:nbn:se:umu:diva-3195 (URN)
Available from: 2008-05-13 Created: 2008-05-13 Last updated: 2010-01-13Bibliographically approved
2. Assessment of functional outcome in a national quality register for acute stroke: can simple self-reported items be transformed into the modified Rankin Scale?
Open this publication in new window or tab >>Assessment of functional outcome in a national quality register for acute stroke: can simple self-reported items be transformed into the modified Rankin Scale?
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2007 (English)In: Stroke, ISSN 1524-4628, Vol. 38, no 4, 1384-1386 p.Article in journal (Refereed) Published
Keyword
Activities of Daily Living, Aged, Cerebrovascular Accident/*epidemiology/rehabilitation, Disability Evaluation, Female, Humans, Interviews, Male, Mobility Limitation, Outcome Assessment (Health Care)/*methods/standards, Quality Assurance; Health Care/*methods/standards/statistics & numerical data, Quality of Life, Registries/*standards/statistics & numerical data, Reproducibility of Results, Self-Evaluation Programs/*methods/standards/statistics & numerical data, Sweden
Identifiers
urn:nbn:se:umu:diva-16978 (URN)doi:10.1161/01.STR.0000260102.97954.9c (DOI)17322093 (PubMedID)
Available from: 2007-10-25 Created: 2007-10-25Bibliographically approved
3. Functional outcome 3 months after stroke predicts long-term survival.
Open this publication in new window or tab >>Functional outcome 3 months after stroke predicts long-term survival.
2008 (English)In: Cerebrovascular diseases (Basel, Switzerland), ISSN 1421-9786, Vol. 25, no 5, 423-429 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: When reporting stroke survival and prognostic factors with a possible effect on outcome, the starting point for the observation of a clinical cohort usually is the onset of stroke or the acute admission of a patient. Thus, acute and early mortality inflict prognosis on long-term outcome. In order to give a more robust analysis of long-term survival after the acute period we chose to start our observation with 3-month survivors. METHODS: We used data from Riks-Stroke, the Swedish quality register for stroke care, together with survival information from the Swedish population register to explore the influence of disability level 3 months after stroke on long-term survival. The main analysis included 15,959 stroke patients, registered during 2001-2002, who had been independent in primary activities of daily living before stroke, had suffered an ischaemic or a haemorrhagic stroke and reported no previous stroke. RESULTS: Impaired functional outcome after stroke was an independent predictor of poor survival. Patients with modified Rankin scale (mRS) grades 3, 4 and 5 had hazard ratios of 1.7, 2.5 and 3.8, respectively, as compared with patients with lower mRS grades. In addition to high mRS, male sex, high age, diabetes, smoking, hypertension therapy at stroke onset, atrial fibrillation and depressed mood were also recognized as significant predictors of poor survival using a multiple Cox regression model. CONCLUSION: The influence of disability on survival is stronger than that of several other well-known prognostic factors. This finding indicates that any intervention in the acute phase that may improve functional status at 3 months will also have favourable secondary effects on survival in the long term.

Identifiers
urn:nbn:se:umu:diva-19411 (URN)10.1159/000121343 (DOI)18349536 (PubMedID)
Available from: 2009-03-05 Created: 2009-03-05 Last updated: 2011-05-18
4. Self-reported depression and use of antidepressants after stroke: a national survey.
Open this publication in new window or tab >>Self-reported depression and use of antidepressants after stroke: a national survey.
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2004 (English)In: Stroke, ISSN 1524-4628, Vol. 35, no 4, 936-941 p.Article in journal (Refereed) Published
Keyword
Aged, Antidepressive Agents/*therapeutic use, Cerebrovascular Accident/*complications, Depression/diagnosis/*drug therapy/*epidemiology/etiology, Female, Follow-Up Studies, Health Surveys, Humans, Male, Prevalence, Registries, Risk Factors, Sweden/epidemiology
Identifiers
urn:nbn:se:umu:diva-12940 (URN)10.1161/01.STR.0000121643.86762.9a (DOI)15001790 (PubMedID)
Available from: 2007-04-25 Created: 2007-04-25 Last updated: 2016-09-26Bibliographically approved

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