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Effect of interleukin-1beta on tyrosine uptake in fibroblasts of schizophrenic patients and healthy controls
Örebro University, Department of Clinical Medicine.
2007 (English)Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

A repeated finding in schizophrenic patients is an aberrant tyrosine transport, shown in fibroblast cell model. Altered levels of the pro-inflammatory cytokine interleukin-1beta (IL-1β) are indicated in schizophrenic patients and IL-1β has shown to have inhibitory effect on amino acid transport systems. Based on these findings, the aim of this study was to examine the effect of IL-1β on tyrosine uptake in fibroblasts of schizophrenic patients and healthy controls. Fibroblast cell lines from schizophrenic patients (n=10) and healthy controls (n=10) were treated with IL-1β and uptake of 14C (U)-L-tyrosine was measured using the cluster tray method. Fibroblasts untreated with IL-1β were used as controls. Treatment with IL-1β significantly inhibited the tyrosine uptake in fibroblasts of schizophrenic patients and controls. No difference in uptake levels between fibroblasts of schizophrenic patients and controls was found. This study provides one potential explanation for the aberrant tyrosine transport seen in patients with schizophrenia and thus combines the immunological and neuropharmacological factors implicated in the pathophysiology/etiology of schizophrenia.

Place, publisher, year, edition, pages
2007. , 21 p.
Keyword [en]
tyrosine uptake, interleukin-1β, fibroblasts, schizophrenia
National Category
Clinical Science
Identifiers
URN: urn:nbn:se:oru:diva-4875OAI: oai:DiVA.org:oru-4875DiVA: diva2:139176
Presentation
(English)
Uppsok
lantbruk/veterinärmed./skogl. vetenskap
Supervisors
Available from: 2009-07-13 Created: 2009-07-13 Last updated: 2017-10-18Bibliographically approved

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