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Dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment in vivo
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.
Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-9267-2191
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2016 (English)In: Oncoimmunology, ISSN 2162-4011, E-ISSN 2162-402X, Vol. 5, no 10, e1229723Article in journal (Refereed) Published
Abstract [en]

Inflammation is one of the hallmarks of carcinogenesis. High mammographic density has been associated with increased risk of breast cancer but the mechanisms behind are poorly understood. We evaluated whether breasts with different mammographic densities exhibited differences in the inflammatory microenvironment.Postmenopausal women attending the mammography-screening program were assessed having extreme dense, n = 20, or entirely fatty breasts (nondense), n = 19, on their regular mammograms. Thereafter, the women were invited for magnetic resonance imaging (MRI), microdialysis for the collection of extracellular molecules in situ and a core tissue biopsy for research purposes. On the MRI, lean tissue fraction (LTF) was calculated for a continuous measurement of breast density. LTF confirmed the selection from the mammograms and gave a continuous measurement of breast density. Microdialysis revealed significantly increased extracellular in vivo levels of IL-6, IL-8, vascular endothelial growth factor, and CCL5 in dense breast tissue as compared with nondense breasts. Moreover, the ratio IL-1Ra/IL-1 was decreased in dense breasts. No differences were found in levels of IL-1, IL-1Ra, CCL2, leptin, adiponectin, or leptin:adiponectin ratio between the two breast tissue types. Significant positive correlations between LTF and the pro-inflammatory cytokines as well as between the cytokines were detected. Stainings of the core biopsies exhibited increased levels of immune cells in dense breast tissue.Our data show that dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironment and, if confirmed in a larger cohort, suggests novel targets for prevention therapies for women with dense breast tissue.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS INC , 2016. Vol. 5, no 10, e1229723
Keyword [en]
Cytokines; mammary gland; mammography; microdialysis; MRI
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-133020DOI: 10.1080/2162402X.2016.1229723ISI: 000387271300023PubMedID: 27853653OAI: oai:DiVA.org:liu-133020DiVA: diva2:1054661
Note

Funding Agencies|Swedish Cancer Society [2015/309]; Swedish Research Council [2013-2457]; LiU-Cancer; Research Funds of Linkoping University Hospital

Available from: 2016-12-08 Created: 2016-12-07 Last updated: 2017-04-06

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Abrahamsson, AnnelieRzepecka, AnnaRomu, ThobiasBorga, MagnusDahlqvist Leinhard, OlofLundberg, PeterKihlberg, JohanDabrosin, Charlotta
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Division of Clinical SciencesFaculty of Medicine and Health SciencesDivision of Radiological SciencesDepartment of Radiology in LinköpingMedical InformaticsFaculty of Science & EngineeringCenter for Medical Image Science and Visualization (CMIV)Department of Radiation PhysicsDepartment of Oncology
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