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Cancer of the Colon and Rectum: Population Based Survival Analysis and Study on Adverse Effects of Radiation Therapy for Rectal Cancer
Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper.
2006 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

The Swedish Cancer Register was used to determine the relative survival rate in colon and rectal cancer and to estimate the occurrence of second cancers related to radiation therapy for rectal cancer. The Swedish Hospital Discharge Register and hospital records were used to estimate the rate of late adverse effects due to radiation therapy for rectal cancer. The whole Swedish population was the source of the survival studies. Patients participating in the Uppsala Trial and the Swedish Rectal Cancer Trial on radiation therapy for rectal cancer constituted the subjects of the studies on late adverse effects and second cancers.

The main results of the survival analysis revealed a significant improvement in the 5-year relative survival rate for both colon and rectal cancer. During the time period 1960-1999, the survival improved from 39.6% to 57.2% in colon cancer and from 36.1% to 57.6% in rectal cancer.

Patients irradiated for rectal cancer, in addition to surgery, were at increased risk for a second cancer compared to those treated by surgery alone. This risk increase was mainly found for cancers developing in organs within or adjacent to the irradiated target (relative risk (RR) 2.04; 95% confidence interval (CI) 1.10–3.79). Furthermore, the most important late adverse effects of radiation therapy seem to be those on the gastrointestinal tract, in the form of small bowel obstruction (RR 1.88; 95%CI 1.10–3.20) and abdominal pain (RR 1.92; 95% CI 1.14–3.23). Overall, the benefit of radiation therapy was greater than its drawbacks, as a large reduction in local recurrences and better survival was noted in patients treated preoperatively with irradiation for rectal cancer.

In conclusion, significant improvements in the survival of patients with colon and rectal cancers have occurred in the last decades, especially in patients with rectal cancer. These improvements probably are related to advances in surgical and adjuvant treatment. The radiation therapy has several drawbacks, however, including an increased risk of second cancers and of bowel obstruction. This emphasises the need to further improve the radiation technique and to select only those patients for radiation therapy who are most likely to benefit from it.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis , 2006. , s. 76
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 145
Nyckelord [en]
Surgery, cancer, colon, rectal, colorectal, survival, radiation therapy, second cancer, adverse effects
Nyckelord [sv]
Kirurgi
Identifikatorer
URN: urn:nbn:se:uu:diva-6824ISBN: 91-554-6543-9 (tryckt)OAI: oai:DiVA.org:uu-6824DiVA, id: diva2:168206
Disputation
2006-05-19, Auditorium minor, Museum Gustavianum, Uppsala, 09:15
Opponent
Handledare
Tillgänglig från: 2006-04-28 Skapad: 2006-04-28Bibliografiskt granskad
Delarbeten
1. Improved survival in cancer of the colon and rectum in Sweden.
Öppna denna publikation i ny flik eller fönster >>Improved survival in cancer of the colon and rectum in Sweden.
Visa övriga...
2005 Ingår i: European Journal of Surgical Oncology, ISSN 0748-7983, Vol. 31, nr 8, s. 845-853Artikel i tidskrift (Refereegranskat) Published
Identifikatorer
urn:nbn:se:uu:diva-94373 (URN)
Tillgänglig från: 2006-04-28 Skapad: 2006-04-28Bibliografiskt granskad
2. Occurrence of second cancers in patients treated with radiotherapy for rectal cancer
Öppna denna publikation i ny flik eller fönster >>Occurrence of second cancers in patients treated with radiotherapy for rectal cancer
2005 Ingår i: Journal of Clinical Oncology, ISSN 0732-183X, Vol. 23, nr 25, s. 6126-6131Artikel i tidskrift (Refereegranskat) Published
Identifikatorer
urn:nbn:se:uu:diva-94374 (URN)
Tillgänglig från: 2006-04-28 Skapad: 2006-04-28Bibliografiskt granskad
3. Adverse effects of preoperative radioation therapy for rectal cancer: Long-term follow-up of the Swedish Rectal Cancer Trial
Öppna denna publikation i ny flik eller fönster >>Adverse effects of preoperative radioation therapy for rectal cancer: Long-term follow-up of the Swedish Rectal Cancer Trial
2005 Ingår i: Journal of Clinical Oncology, ISSN 0732-183X, Vol. 23, nr 34, s. 8697-8705Artikel i tidskrift (Refereegranskat) Published
Identifikatorer
urn:nbn:se:uu:diva-94375 (URN)
Tillgänglig från: 2006-04-28 Skapad: 2006-04-28Bibliografiskt granskad
4. Late gastrointestinal disorders after surgery for rectal cancer and the relationship to preoperative radiation therapy
Öppna denna publikation i ny flik eller fönster >>Late gastrointestinal disorders after surgery for rectal cancer and the relationship to preoperative radiation therapy
Manuskript (Övrigt vetenskapligt)
Identifikatorer
urn:nbn:se:uu:diva-94376 (URN)
Tillgänglig från: 2006-04-28 Skapad: 2006-04-28 Senast uppdaterad: 2010-01-13Bibliografiskt granskad

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