Ändra sökning
Länk till posten
Permanent länk

Direktlänk
BETA
Lichtwarck-Aschoff, Michael
Alternativa namn
Publikationer (10 of 37) Visa alla publikationer
Schumann, S., Vimlati, L., Kawati, R., Guttmann, J. & Lichtwarck-Aschoff, M. (2018). Cardiogenic oscillations to detect intratidal derecruitment and overdistension in a porcine model of healthy and atelectatic lungs. British Journal of Anaesthesia, 121(4), 928-935
Öppna denna publikation i ny flik eller fönster >>Cardiogenic oscillations to detect intratidal derecruitment and overdistension in a porcine model of healthy and atelectatic lungs
Visa övriga...
2018 (Engelska)Ingår i: British Journal of Anaesthesia, ISSN 0007-0912, E-ISSN 1471-6771, Vol. 121, nr 4, s. 928-935Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Low positive end-expiratory pressure (PEEP) can result in alveolar derecruitment, and high PEEP or high tidal volume (V-T) in lung overdistension. We investigated cardiogenic oscillations (COS) in the airway pressure signal to investigate whether these oscillations can assess unfavourable intratidal events. COS induce short instantaneous compliance increases within the pressure-volume curve, and consequently in the compliance-volume curve. We hypothesised that increases in COS-induced compliance reflect non-linear intratidal respiratory system mechanics. Methods: In mechanically ventilated anaesthetised pigs with healthy (n = 13) or atelectatic (n = 12) lungs, pressure-volume relationships and the ECG were acquired at a PEEP of 0, 5, 10, and 15 cm H2O. During inspiration, the peak compliance of successive COS (C-COS) was compared with intratidal respiratory system compliance (C-RS) within incremental volume steps up to the full V-T of 12 ml kg(-1). We analysed whether C-COS variation corresponded with systolic arterial pressure variation. Results: C-COS-volume curves showed characteristic intratidal patterns depending on the PEEP level and on atelectasis. Increasing C-RS- or C-COS-volume patterns were associated with intratidal derecruitment with low PEEP, and decreasing patterns above 6 ml kg(-1) and high PEEP showed overdistension. C-COS was not associated with systolic arterial pressure variations. Conclusions: Heartbeat-induced oscillations within the course of the inspiratory pressure-volume curve reflect nonlinear intratidal respiratory system mechanics. The analysis of these cardiogenic oscillations can be used to detect intratidal derecruitment and overdistension and, hence, to guide PEEP and V-T settings that are optimal for respiratory system mechanics.

Nyckelord
blood pressure, lung compliance, mechanical ventilation, positive end-expiratory pressure, respiratory mechanics, ventilators
Nationell ämneskategori
Anestesi och intensivvård
Identifikatorer
urn:nbn:se:uu:diva-368990 (URN)10.1016/j.bja.2018.02.068 (DOI)000447401000029 ()30236255 (PubMedID)
Tillgänglig från: 2018-12-14 Skapad: 2018-12-14 Senast uppdaterad: 2018-12-14Bibliografiskt granskad
Buehler, S., Schumann, S., Vimlati, L., Lichtwarck-Aschoff, M. & Guttmann, J. (2015). Simultaneous monitoring of intratidal compliance and resistance in mechanically ventilated piglets: A feasibility study in two different study groups. Respiratory Physiology & Neurobiology, 219, 36-42
Öppna denna publikation i ny flik eller fönster >>Simultaneous monitoring of intratidal compliance and resistance in mechanically ventilated piglets: A feasibility study in two different study groups
Visa övriga...
2015 (Engelska)Ingår i: Respiratory Physiology & Neurobiology, ISSN 1569-9048, E-ISSN 1878-1519, Vol. 219, s. 36-42Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Compliance measures the force counteracting parenchymal lung distension. In mechanical ventilation, intratidal compliance-volume (C(V))-profiles therefore change depending on PEEP, tidal volume (V-T), and underlying mechanical lung properties. Resistance counteracts gas flow through the airways. Due to anatomical linking between parenchyma and airways, intratidal resistance-volume (R(V))-profiles are hypothesised to change in a non-linear way as well. We analysed respiratory system mechanics in fifteen piglets with lavage-induced lung injury and nine healthy piglets ventilated at different PEEP/V-T-settings. In healthy lungs, R(V)-profiles remained mostly constant and linear at all PEEP-settings whereas the shape of the C(V)-profiles showed an increase toward a maximum followed by a decrease (small PEEP) or volume-dependent decrease (large PEEP). In the lavage group, a large drop in resistance at small volumes and slow decrease toward larger volumes was found for small PEEP/V-T-settings where C(V)-profiles revealed a volume-dependent increase (small PEEP) or a decrease (large PEEP and large VT). R(V)-profiles depend characteristically on PEEP, V-T, and possibly whether lungs are healthy or not. Curved R(V)-profiles might indicate pathological changes in the underlying mechanical lung properties and/or might be a sign of derecruitment.

Nyckelord
Respiratory mechanics, Mechanical ventilation, Resistance, Compliance, PEEP
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:uu:diva-270439 (URN)10.1016/j.resp.2015.08.001 (DOI)000365058500006 ()26275684 (PubMedID)
Tillgänglig från: 2016-02-08 Skapad: 2015-12-28 Senast uppdaterad: 2017-11-30Bibliografiskt granskad
Schumann, S., Goebel, U., Haberstroh, J., Vimlati, L., Schneider, M., Lichtwarck-Aschoff, M. & Guttmann, J. (2014). Determination of respiratory system mechanics during inspiration and expiration by FLow-controlled EXpiration (FLEX): a pilot study in anesthetized pigs. Minerva Anestesiologica, 80(1), 19-28
Öppna denna publikation i ny flik eller fönster >>Determination of respiratory system mechanics during inspiration and expiration by FLow-controlled EXpiration (FLEX): a pilot study in anesthetized pigs
Visa övriga...
2014 (Engelska)Ingår i: Minerva Anestesiologica, ISSN 0375-9393, E-ISSN 1827-1596, Vol. 80, nr 1, s. 19-28Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background. Differences between inspiratory and expiratory lung mechanics result in the hysteresis of the pressure volume-loop. While hysteresis area is a global parameter describing the difference between inspiration and expiration in mechanics under quasi-static conditions, a detailed analysis of this difference under the dynamic conditions of mechanical ventilation is feasible once inspiratory and expiratory compliance (C-in/C-ex) are determined separately. This requires uncoupling of expiratory flow rate and volume (V). Methods. Five piglets were mechanically ventilated at positive end-expiratory pressure (PEEP) levels ranging from 0 to 15 cmH(2)O. Expiratory flow rate was linearized by a computer-controlled resistor (flow-controlled expiration). The volume-dependent C-in(V) and C-ex(V) profiles were calculated from the tracheal pressure volume-loops. Results. The intratidal curve-progression of C-ex(V) was altogether higher with a steeper slope compared to C-in(V). With increasing positive end-expiratory pressure (PEEP) dynamic hysteresis area decreased and C-ex(V) tended to run more parallel to C-in(V), Conclusion. The relation between inspiratory and expiratory compliance profiles is associated with the hysteresis area and behaves PEEP dependent. Analysing the C-in-C-ex-relation might therefore potentially offer a new approach to titrate PEEP and tidal volume.

Nyckelord
Compliance, Respiratory system, Peak expiratory flow rate, Respiratory mechanics
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-221724 (URN)000332140600006 ()
Tillgänglig från: 2014-04-04 Skapad: 2014-04-03 Senast uppdaterad: 2017-12-05Bibliografiskt granskad
Schumann, S., Vimlati, L., Lichtwarck-Aschoff, M. & Guttmann, J. (2013). Dynamic Hysteresis Behaviour of Respiratory System Mechanics. Paper presented at Tri-State Conference of the German-Swiss-and-Austrian-Society-for-Biomedical-Technology (BMT), 2013, Graz, AUSTRIA. Biomedizinische Technik (Berlin. Zeitschrift), 58
Öppna denna publikation i ny flik eller fönster >>Dynamic Hysteresis Behaviour of Respiratory System Mechanics
2013 (Engelska)Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 58Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The static pressure-volume (PV) curve of the respiratory system is characterized by hysteresis behaviour. Determination of separate inspiratory and expiratory compliance is required to analyse this phenomenon during the dynamic situation of mechanical ventilation. In five piglets expiratory flow was linearized (flow-controlled expiration, FLEX) to allow for compliance estimation separately for inspiration and expiration. Expiratory compliance was higher than inspiratory compliance along the entire intratidal course, converging at higher volumes. At higher PEEP levels expiratory and inspiratory compliance tended to run more in parallel. We conclude that the analysis of the separate inspiratory and expiratory compliance profiles allows for indicating unfavourable mechanical ventilation settings.

Nyckelord
Expiratory peak flow, flow-controlled expiration, mechanical ventilation, respiratory system compliance
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-219881 (URN)10.1515/bmt-2013-4119 (DOI)000329463600119 ()
Konferens
Tri-State Conference of the German-Swiss-and-Austrian-Society-for-Biomedical-Technology (BMT), 2013, Graz, AUSTRIA
Tillgänglig från: 2014-03-12 Skapad: 2014-03-06 Senast uppdaterad: 2017-12-05Bibliografiskt granskad
Vimlati, L., Larsson, A., Hedenstierna, G. & Lichtwarck-Aschoff, M. (2013). Pulmonary shunt is independent of decrease in cardiac output during unsupported spontaneous breathing in the pig. Anesthesiology, 118(4), 914-923
Öppna denna publikation i ny flik eller fönster >>Pulmonary shunt is independent of decrease in cardiac output during unsupported spontaneous breathing in the pig
2013 (Engelska)Ingår i: Anesthesiology, ISSN 0003-3022, E-ISSN 1528-1175, Vol. 118, nr 4, s. 914-923Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: During mechanical ventilation (MV), pulmonary shunt is cardiac output (CO) dependent; however, whether this relationship is valid during unsupported spontaneous breathing (SB) is unknown. The CO dependency of the calculated venous admixture was investigated, with both minor and major shunt, during unsupported SB, MV, and SB with continuous positive airway pressure (CPAP). Methods: In seven anesthetized supine piglets breathing 100% oxygen, unsupported SB, MV (with tidal volume and respiratory rate corresponding to SB), and 8 cm H2O CPAP (airway pressure corresponding to MV) were applied at random. Venous return and CO were reduced by partial balloon occlusion of the inferior vena cava. Measurements were repeated with the left main bronchus blocked, creating a nonrecruitable pulmonary shunt. Results: CO decreased from 4.2 l/min (95% CI, 3.9-4.5) to 2.5 l/min (95% CI, 2.2-2.7) with partially occluded venous return. Irrespective of whether shunt was minor or major, during unsupported SB, venous admixture was independent of CO (slope: minor shunt, 0.5; major shunt, 1.1%.min(-1).l(-1)) and mixed venous oxygen tension. During both MV and CPAP, venous admixture was dependent on CO (slope MV: minor shunt, 1.9; major shunt, 3.5; CPAP: minor shunt, 1.3; major shunt, 2.9% .min(-1).l(-1)) and mixed-venous oxygen tension (coefficient of determination 0.61-0.86 for all regressions). Conclusions: In contrast to MV and CPAP, venous admixture was independent of CO during unsupported SB, and was unaffected by mixed-venous oxygen tension, casting doubt on the role of hypoxic pulmonary vasoconstriction in pulmonary blood flow redistribution during unsupported SB.

Nyckelord
pulmonary shunt, cardiac output, mechanical ventilation, spontaneous breathing
Nationell ämneskategori
Anestesi och intensivvård
Forskningsämne
Fysiologi
Identifikatorer
urn:nbn:se:uu:diva-182302 (URN)10.1097/ALN.0b013e318283c81f (DOI)000316355000021 ()
Tillgänglig från: 2012-10-11 Skapad: 2012-10-09 Senast uppdaterad: 2017-12-07Bibliografiskt granskad
Buehler, S., Schumann, S., Lichtwarck-Aschoff, M., Lozano, S. & Guttmann, J. (2013). The shape of intratidal resistance-volume and compliance-volume curves in mechanical ventilation - an animal study. Paper presented at Tri-State Conference of the German-Swiss-and-Austrian-Society-for-Biomedical-Technology (BMT), 2013, Graz, AUSTRIA. Biomedizinische Technik (Berlin. Zeitschrift), 58
Öppna denna publikation i ny flik eller fönster >>The shape of intratidal resistance-volume and compliance-volume curves in mechanical ventilation - an animal study
Visa övriga...
2013 (Engelska)Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 58Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

In respiratory system mechanics, the shape of the intratidal pulmonary compliance-volume curve can be used to detect atelectasis or overdistension in the mechanically ventilated lung and thus to optimise the ventilator setting in terms of positive end-expiratory pressure (PEEP) and tidal volume (V-T). To this end, a set of shape-categories had been suggested. Furthermore, a characteristic behaviour of the intratidal resistance is expected as a consequence of alveolar recruitment and overdistension of the airways. We inspect the intratidal compliance and resistance profiles in mechanically ventilated pigs and suggest a classification into slope-categories for the resistance profile which could be used in combination with the compliance shape-categories to optimize PEEP and V-T.

Nyckelord
respiratory system mechanics, mechanical ventilation, intratidal resistance, intratidal compliance
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-219880 (URN)10.1515/bmt-2013-4118 (DOI)000329463600118 ()
Konferens
Tri-State Conference of the German-Swiss-and-Austrian-Society-for-Biomedical-Technology (BMT), 2013, Graz, AUSTRIA
Tillgänglig från: 2014-03-12 Skapad: 2014-03-06 Senast uppdaterad: 2017-12-05Bibliografiskt granskad
Vimláti, L., Larsson, A., Hedenstierna, G. & Lichtwarck-Aschoff, M. (2012). Haemodynamic stability and pulmonary shunt during spontaneous breathing and mechanical ventilation in porcine lung collapse. Acta Anaesthesiologica Scandinavica, 56(6), 748-754
Öppna denna publikation i ny flik eller fönster >>Haemodynamic stability and pulmonary shunt during spontaneous breathing and mechanical ventilation in porcine lung collapse
2012 (Engelska)Ingår i: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 56, nr 6, s. 748-754Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background

We investigated the haemodynamic stability of a novel porcine model of lung collapse induced by negative pressure application (NPA). A secondary aim was to study whether pulmonary shunt correlates with cardiac output (CO).

Methods

In 12 anaesthetized and relaxed supine piglets, lung collapse was induced by NPA (−50 kPa). Six animals resumed spontaneous breathing (SB) after 15 min; the other six animals were kept on mechanical ventilation (MV) at respiratory rate and tidal volume (VT) that corresponded to SB. All animals were followed for 135 min with blood gas analysis and detailed haemodynamic monitoring.

Results

Haemodynamics and gas exchange were stable in both groups during the experiment with arterial oxygen tension (PaO2)/inspired fraction of oxygen (FiO2) and pulmonary artery occlusion pressure being higher, venous admixture (Qva/Qt) and pulmonary perfusion pressure being lower in the SB group. CO was similar in both groups, showing slight decrease over time in the SB group. During MV, Qva/Qt increased with CO (slope: 4.3 %min/l; P < 0.001), but not so during SB (slope: 0.55 %min/l; P = 0.16).

Conclusions

This porcine lung collapse model is reasonably stable in terms of haemodynamics for at least 2 h irrespective of the mode of ventilation. SB achieves higher PaO2/FiO2 and lower Qva/Qt compared with MV. During SB, Qva/Qt seems to be less, if at all, affected by CO compared with MV.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-175676 (URN)10.1111/j.1399-6576.2012.02700.x (DOI)000305070400012 ()22524589 (PubMedID)
Tillgänglig från: 2012-06-11 Skapad: 2012-06-11 Senast uppdaterad: 2017-12-07Bibliografiskt granskad
Schumann, S., Vimlati, L., Kawati, R., Guttmann, J. & Lichtwarck-Aschoff, M. (2011). Analysis of Dynamic Intratidal Compliance in a Lung Collapse Model. Anesthesiology, 114(5), 1111-1117
Öppna denna publikation i ny flik eller fönster >>Analysis of Dynamic Intratidal Compliance in a Lung Collapse Model
Visa övriga...
2011 (Engelska)Ingår i: Anesthesiology, ISSN 0003-3022, E-ISSN 1528-1175, Vol. 114, nr 5, s. 1111-1117Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: For mechanical ventilation to be lung-protective, an accepted suggestion is to place the tidal volume (V-T) between the lower and upper inflection point of the airway pressure-volume relation. The drawback of this approach is, however, that the pressure-volume relation is assessed under quasistatic, no-flow conditions, which the lungs never experience during ventilation. Intratidal nonlinearity must be assessed under real (i.e., dynamic) conditions. With the dynamic gliding-SLICE technique that generates a high-resolution description of intratidal mechanics, the current study analyzed the profile of the compliance of the respiratory system (C-RS).

Methods: In 12 anesthetized piglets with lung collapse, the pressure-volume relation was acquired at different levels of positive end-expiratory pressure (PEEP: 0, 5, 10, and 15 cm H2O). Lung collapse was assessed by computed tomography and the intratidal course of C-RS using the gliding-SLICE method.

Results: Depending on PEEP, C-RS showed characteristic profiles. With low PEEP, C-RS increased up to 20% above the compliance at early inspiration, suggesting intratidal recruitment; whereas a profile of decreasing C-RS, signaling overdistension, occurred with V-T > 5 ml/kg and high PEEP levels. At the highest volume range, C-RS was up to 60% less than the maximum. With PEEP 10 cm H2O, C-RS was high and did not decrease before 5 ml/kg V-T was delivered.

Conclusions: The profile of dynamic C-RS reflects nonlinear intratidal mechanics of the respiratory system. The SLICE analysis has the potential to detect intratidal recruitment and overdistension. This might help in finding a combination of PEEP and V-T level that is protective from a lung-mechanics perspective.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-153651 (URN)10.1097/ALN.0b013e31820ad41b (DOI)000289980200015 ()21336098 (PubMedID)
Tillgänglig från: 2011-05-17 Skapad: 2011-05-17 Senast uppdaterad: 2017-12-11Bibliografiskt granskad
Schumann, S., Messmer, F., Lichtwarck-Aschoff, M., Haberthuer, C. & Guttmann, J. (2011). Cardiogenic oscillations in spontaneous breathing airway signal reflect respiratory system mechanics. Acta Anaesthesiologica Scandinavica, 55(8), 980-986
Öppna denna publikation i ny flik eller fönster >>Cardiogenic oscillations in spontaneous breathing airway signal reflect respiratory system mechanics
Visa övriga...
2011 (Engelska)Ingår i: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 55, nr 8, s. 980-986Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Heartbeat-related pressure oscillations appear at the airway opening. We investigated whether these cardiogenic oscillations (COS) - extracted from spontaneous breathing signals - reflect the compliance of the respiratory system. Methods: Fifteen volunteers breathed spontaneously at normal or reduced chest wall compliance, i.e. with and without thorax strapping, and at normal or reduced lung compliance, induced by positive end-expiratory pressure (PEEP). COS-related signals were extracted by averaging the flow and pressure curve sections, temporally aligned to the electrocardiogram signal. Results: COS-related airway pressure and flow curves correlated closely for each subject (r(2) =0.97±0.02, P<0.0001). At the unstrapped thorax, the oscillation's amplitudes were 0.07±0.03 cmH(2) O (pressure) and 22±10 ml/s (flow). COS-related pressure amplitudes correlated closely with the ratio of tidal volume divided by pressure amplitude (r(2) =0.88, P<0.001) and furthermore increased with either thorax strapping (P<0.001) or with increasing PEEP (P=0.049). Conclusion: We conclude that COS extracted from the pressure and flow signal reflect the compliance of the respiratory system and could potentially allow estimating respiratory system mechanics during spontaneous breathing.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-158404 (URN)10.1111/j.1399-6576.2011.02488.x (DOI)21770903 (PubMedID)
Tillgänglig från: 2011-09-07 Skapad: 2011-09-07 Senast uppdaterad: 2017-12-08Bibliografiskt granskad
Vimlati, L., Kawati, R., Hedenstierna, G., Larsson, A. & Lichtwarck-Aschoff, M. (2011). Spontaneous Breathing Improves Shunt Fraction and Oxygenation in Comparison with Controlled Ventilation at a Similar Amount of Lung Collapse. Anesthesia and Analgesia, 113(5), 1089-1095
Öppna denna publikation i ny flik eller fönster >>Spontaneous Breathing Improves Shunt Fraction and Oxygenation in Comparison with Controlled Ventilation at a Similar Amount of Lung Collapse
Visa övriga...
2011 (Engelska)Ingår i: Anesthesia and Analgesia, ISSN 0003-2999, E-ISSN 1526-7598, Vol. 113, nr 5, s. 1089-1095Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Spontaneous breathing (SB), when allowed during mechanical ventilation (MV), improves oxygenation in different models of acute lung injury. However, it is not known whether oxygenation is improved during mechanically unsupported SB. Therefore, we compared SB without any support with controlled MV at identical tidal volume (V(T)) and respiratory rate (RR) without positive end-expiratory pressure in a porcine lung collapse model.

METHODS: In 25 anesthetized piglets, stable lung collapse was induced by application of negative pressure, and animals were randomized to either resume SB or to be kept on MV at identical VT (5 mL/kg; 95% confidence interval: 3.8 to 6.4) and RR (65 per minute [57 to 73]) as had been measured during an initial SB period. Oxygenation was assessed by blood gas analysis (n = 15) completed by multiple inert gas elimination technique (n = 8 of the 15) for shunt measurement. In addition, possible lung recruitment was studied with computed tomography of the chest (n = 10).

RESULTS: After induction of lung collapse, PaO(2)/FIO(2) decreased to 90 mm Hg (76 to 103). With SB, PaO(2)/FIO(2) increased to 235 mm Hg (177 to 293) within 15 minutes, whereas MV at identical VT and RR did not cause any improvement in oxygenation. Intrapulmonary shunt by 45 minutes after induction of lung collapse was lower during SB (SB: 27% [24 to 30] versus MV: 41% [28 to 55]; P = 0.017). Neither SB nor MV reduced collapsed lung areas on computed tomography.

CONCLUSIONS: SB without any support improves oxygenation and reduces shunt in comparison with MV at identical settings. This seems to be achieved without any major signs of recruitment of collapsed lung regions.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-161927 (URN)10.1213/ANE.0b013e31822ceef8 (DOI)000296236200025 ()
Tillgänglig från: 2011-11-23 Skapad: 2011-11-21 Senast uppdaterad: 2017-12-08Bibliografiskt granskad
Organisationer

Sök vidare i DiVA

Visa alla publikationer