1234567 51 - 100 of 1624
rss atomLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
  • Wadensjö, Eskil
    Stockholm University, Faculty of Social Sciences, The Swedish Institute for Social Research (SOFI)..
    Recension av Hélio Manhica, Mental health, substance misuse and labour market participation in teenage refugees in Sweden – A longitudinal perspective (Doktorsavhandling i folkhälsovetenskap vid Stockholms universitet, Centre for Health Equity Studies (CHESS), 2017).2017Inngår i: Arbetsmarknad & Arbetsliv, ISSN 1400-9692, Vol. 23, nr 4, s. 79-81Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • Bojan, Kobalsic
    et al.
    Högskolan Kristianstad, Fakulteten för ekonomi.
    Musonda, Lilian
    Högskolan Kristianstad, Fakulteten för ekonomi.
    Quantitative study III: what makes foreign students happy?2018Inngår i: Högskolepedagogisk debatt, ISSN 2000-9216, nr 1, s. 155-177Artikkel i tidsskrift (Annet vitenskapelig)
  • Disputas: 2018-11-09 13:15 Hörsal 2, Ekonomikum, Uppsala
    Wiell, Karolina
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Ekonomisk-historiska institutionen.
    Bad mot Lort och Sjukdom: Den privathygieniska utvecklingen i Sverige 1880–19492018Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    In this thesis, the question of why a large number of small, modest, public baths (saunas) were built on the Swedish countryside during 1920–1949 has been analysed. The specific research question has been: How did the idea of the need for the baths, as well better personal hygiene among the Swedish population, develop? The study is based on a number of different sources, including governmental registers, records, and motions to parliament, reports from the organization of the district medical officers, popular science books, leaflets, schoolbooks and magazines.

    When bacteria were identified in the mid-19th century, the new knowledge spread around the world. In Sweden, the district medical officers made personal hygiene (skin care) a main question in the 1890s as a way of making their work important to their employer, Medicinalstyrelsen. It was also away to demonstrate their importance and unique competence when it came to preventive healthcare. The new knowledge, based on assembled health statistics and the idea of hygiene, was distributed to the population through literature such as schoolbooks, women’s magazines, and works of popular science, as well as through compulsory school baths for children. In the end, after almost 40 years, the arguments for personal hygiene formed an ideology that reached the government and resulted in a decision that supported the building boom of small public baths on the Swedish countryside, known as badstugor, to meet the need of an improved personal hygiene in areas where municipal water- and drainage systems were still not established.

    This study contributes to the understanding of personal and societal change. This study also focuses on how economics can be affected by help, adding to the field of economic history. Another aspect is how changes of norms, as well as strong beliefs, can lead to societal changes, new social norms and change behaviour of a population.

  • Bäcklin, Christofer L.
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Cancerfarmakologi och beräkningsmedicin.
    Gustafsson, Mats G.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Cancerfarmakologi och beräkningsmedicin.
    Developer-Friendly and Computationally Efficient Predictive Modeling without Information Leakage: The emil Package for R2018Inngår i: Journal of Statistical Software, ISSN 1548-7660, E-ISSN 1548-7660, Vol. 85, nr 13, s. 1-30Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Data driven machine learning for predictive modeling problems (classification, regression, or survival analysis) typically involves a number of steps beginning with data preprocessing and ending with performance evaluation. A large number of packages providing tools for the individual steps are available for R, but there is a lack of tools for facilitating rigorous performance evaluation of the complete procedures assembled from them by means of cross-validation, bootstrap, or similar methods. Such a tool should strictly prevent test set observations from influencing model training and meta- parameter tuning, so- called information leakage, in order to not produce overly optimistic performance estimates. Here we present a new package for R denoted emil (evaluation of modeling without information leakage) that offers this form of performance evaluation. It provides a transparent and highly customizable framework for facilitating the assembly, execution, performance evaluation, and interpretation of complete procedures for classification, regression, and survival analysis. The components of package emil have been designed to be as modular and general as possible to allow users to combine, replace, and extend them if needed. Package emil was also developed with scalability in mind and has a small computational overhead, which is a key requirement for analyzing the very big data sets now available in fields like medicine, physics, and finance. First package emil's functionality and usage is explained. Then three specific application examples are presented to show its potential in terms of parallelization, customization for survival analysis, and development of ensemble models. Finally a brief comparison to similar software is provided.

  • Gardesten, Jens
    et al.
    Linnéuniversitetet.
    Hegender, Henrik
    Linnéuniversitetet.
    Underkännanden inom verksamhetsförlagd lärarutbildning - resultat från en forskningsexpedition i svårframkomlig terräng2015Inngår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 9, nr 2, s. 69-86Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This study examined the case of teacher student failures in School Based Teacher Education (SBTE). A questionnaire was distributed to administrators within Swedish teacher education campuses, asking how often failures occur and what procedures following a failure exam. The results show a rather similar share of failures within TE programs, from within 1-3 percent. The results reveal different methods when failure is at risk, including prevention strategies and certain formative interventions to support the students’ further development. Normally the cooperating teacher contact the university to inform that a failure is at risk, but some TE programs let the teacher educators themselves makes early visits in the school placements to make sure if support is needed. Some informants emphasize how important it is to avoid “late failures” when students might feel mistreated, no longer having the chance to correct or adjust the performances before course ending. Finally, some informants explicit note that a failure always is a possible outcome, while other claim the most important task is to support the students' development in different ways. In conclusion, the TE gate keeping function seems to be more or less emphasized.

  • Bruhn, Alina
    et al.
    Högskolan Kristianstad, Fakulteten för ekonomi.
    Hesselroth, Marcus
    Högskolan Kristianstad, Fakulteten för ekonomi.
    Quantitative study II:: what makes foreign students happy?2018Inngår i: Högskolepedagogisk debatt, ISSN 2000-9216, nr 1, s. 131-154Artikkel i tidsskrift (Annet vitenskapelig)
  • Rosvall, Per-Åke
    Umeå universitet.
    Examinationer för elevinflytande?2015Inngår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 9, nr 2, s. 51-67Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Assessments for student influence? The aim of this article is to analyse the relation between assessments and student influence. This is done with examples from ethnographic material, with classroom observations and student and teacher interviews, by analysing two teachers’ pedagogic practices. The teachers were chosen since one teacher, in the interviews with the students, were mentioned as an example of having good pedagogic practice while the other as an example of the opposite. This was interesting because the first teacher left few possibilities to exercise influence while the other emphasised the students to exercise influence quite often. However, in none of the teachers’ pedagogic practices students’ own actions to influence were common. Here the teachers’ assessments seemed to be of great importance. Both teachers examined facts, and the most rational response from the students then were to ask the teachers to stand by the white board telling them what to learn for exams, rather than trying to influence the content of the pedagogic practice with contents of their own interest. The analysis demonstrate that if the students experience examinations as fixed, their motivation to influence the pedagogic practices seems demolished, regardless teachers intentions.

  • Löfgren, Håkan
    et al.
    Linköpings universitet.
    Löfgren, Ragnhild
    Linköpings universitet.
    Alone with the test - student's perspectives on an enacted policy of national testing in Swedish schools2015Inngår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 9, nr 2, s. 35-49Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [sv]

    Den här artikeln handlar om mellanstadieelevers erfarenheter av nationella prov i SO- och NO-ämnen i årskurs 6. Särskilt fokus riktas i artikeln mot hur ansvaret för förberedelser och resultat av nationella prov beskrivs av eleverna. Resultatdokumentation på mellanstadiet är inget nytt i sig, men återinförandet av betyg och fler nationella prov menar vi får konsekvenser för hur kunskapsbedömningar görs och i förlängningen för hur elever formas och formar sig som skolelever. Artikeln är baserad på data från sex gruppintervjuer med elever från tre olika skolor. Eleverna berättar om en ökad press såväl hemma som i skolan att prestera goda resultat på proven, men i elevernas berättelser så framstår de ofta som ensamt ansvariga för såväl förberedelser som resultat. Studien ger en bild av fragmentariska förberedelser i skolan inför proven och av elever som förväntas, och själva vill, visa goda resultat. Eleverna framträder som i huvudsak hänvisade till varandra, stressade, ibland lurade, men också nöjda i sina berättelser om sina erfarenheter av proven. Elevernas identitetsformering beskrivs här som effekter av hur policyn med nationella prov ‘görs’ (is enacted) i lokala praktiker. Detta ses i ljuset av förändringar i utbildningssystemet i riktning mot ett starkare intresse för elevers resultat i ett recentraliserat och konkurrensutsatt skolsystem.

  • Ekecrantz, Stefan
    Stockholms universitet.
    Feedback and student learning? A critical review of research2015Inngår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 9, nr 2, s. 15-34Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [sv]

    Formativ bedömning i allmänhet och feedback i synnerhet har sin givna plats i rådande utbildningsvetenskapliga paradigm. Genom stora översikter, meta-studier och synteser ses feedback på och för lärande som ett empiriskt synnerligen väl grundat fenomen. Den typen av närmast konsensusliknande försanthållanden riskerar att undslippa kritisk granskning över tid. I den här studien görs en uppföljande närläsning av ett särskilt inflytelserikt segment inom feedbackforskningen. Resultatet visar att den underliggande primärforskningen i det fallet inte alls bygger på forskning om elevers och studenters lärande, tvärtemot hur denna forskning har refererats och använts vidare i efterföljande meta-analyser av till exempel Hattie (2009) och Hattie och Timperley (2007). Konsekvenser därav för forskning och evidensbaserad praktik diskuteras.

  • Carlén, Urban
    Högskolan i Skövde.
    Utbildning & Lärande 2015:2: Tema: Examination för lärande? Perspektiv på styreffekter2015Collection/Antologi (Fagfellevurdert)
  • Disputas: 2018-11-13 13:00 sal E306, Arrheniuslaboratorierna, Stockholm
    Martins, António
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut.
    The cell biology and catalytic properties of the nutrient-induced signaling endoprotease Ssy52018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Cells continuously sense and respond to changes in the presence, quality and quantity of external and internal nutrients. Specific signaling proteases have been identified based on their roles in processing or destruction of distinct sets of downstream effector proteins in response to environmental cues. The Saccharomyces cerevisiae Ssy5 signaling endoprotease has a key role in regulating central metabolism, cellular aging, and morphological transitions important for growth and survival. Ssy5 is a core component of the Ssy1–Ptr3-Ssy5 (SPS) sensor, which enables yeast cells to respond to extracellular amino acids and induce their uptake. Ssy5 cleaves transcription factors Stp1 and Stp2, permitting their translocation to the nucleus where they enhance the expression of amino acid permease genes. This thesis focuses on Ssy5, its biogenesis and catalytic properties (paper I), the spatial determinants underlying Ssy5 function in SPS-sensor context (paper II) and substrate cleavage (paper III).

    Ssy5 is comprised of pro- and catalytic-(Cat)-domains. The Cat-domain possesses characteristic hallmarks of a serine protease; however, serine protease-specific inhibitors have limited effect, confounding its classification. In paper I we unambiguously show that Ssy5 is a serine protease, define the precise sites of cleavage in Stp1 and Stp2, and describe the sequence specific requirements of their cleavage. The uniquely large prodomain (381 amino acids) has two essential functions. Initially, it is required in cis for the maturation of the Cat-domain, helping to overcome a folding barrier that is reflected in the high stability of the Cat-domain. Subsequent to attaining enzymatic competence, Ssy5 undergoes an autolytic cleavage event. The domains remain associated and the prodomain functions to fetter the proteolytic activity of the Cat-domain.

    The plasma membrane (PM) localization of Ssy1 has recently been questioned in a report that postulated that Ssy1 is a component of the endoplasmic reticulum (ER) and contributes to the formation of ER-PM junctions. In paper II, using mutational and subcellular fractionation experiments we critically examined this notion that is inconsistent with the current understanding of Ssy5 activation, i.e., the unfettering of the Cat-domain occurs in strict association with Ssy1 at the PM. The data show that Ssy1 is indeed a PM protein, and importantly, Ssy5-activation occurs independent of ER-PM junctions. A di-acidic ER exit motif was identified that is critical for proper PM localization and function of Ssy1. In paper III, we report that the Cat-domain is post-translationally modified in a manner dependent on Ptr3 and the PM casein kinase I (Yck1/2), consistent with Ssy5 activation occurring at the PM. Strikingly, the activated Cat-domain is capable of properly cleaving Stp1 fused to an ER membrane protein. The amino acid-induced cleavage of this artificial membrane-bound substrate occurs in a Δtether strain (ist2Δ scs2Δ scs22Δ tcb1Δ tcb2Δ tcb3Δ) lacking ER-PM junctions. These findings indicate that the activated Cat-domain can bind and functionally interact with substrates distant from the PM. Finally, we show that the Cat-domain is degraded faster in amino acid-induced cells. These findings provide novel insights into the SPS-sensing pathway and demonstrate for the first time that the resetting of the SPS-sensing system correlates with Cat-domain degradation.

  • Milkina, Elena
    et al.
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia;RAS, Natl Sci Ctr Marine Biol FEB, Vladivostok 690041, Russia.
    Ponomarenko, Arina
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia;RAS, Natl Sci Ctr Marine Biol FEB, Vladivostok 690041, Russia.
    Korneyko, Maria
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia.
    Lyakhova, Irina
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia.
    Zayats, Yulia
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia.
    Zaitsev, Sergey
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia.
    Mischenko, Polina
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia;RAS, Natl Sci Ctr Marine Biol FEB, Vladivostok 690041, Russia.
    Eliseikina, Marina
    RAS, Natl Sci Ctr Marine Biol FEB, Vladivostok 690041, Russia.
    Khotimchenko, Yuri
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia;RAS, Natl Sci Ctr Marine Biol FEB, Vladivostok 690041, Russia.
    Shevchenko, Valeryi
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia;NN Blokhin Russian Canc Res Ctr, Moscow 115478, Russia.
    Sharma, Hari Shanker
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Bryukhovetskiy, Igor
    Far Eastern Fed Univ, Sch Biomed, 8 Sukhanova St, Vladivostok 690091, Russia;RAS, Natl Sci Ctr Marine Biol FEB, Vladivostok 690041, Russia.
    Interaction of hematopoietic CD34(+) CD45(+) stem cells and cancer cells stimulated by TGF-beta 1 in a model of glioblastoma in vitro2018Inngår i: Oncology Reports, ISSN 1021-335X, E-ISSN 1791-2431, Vol. 40, nr 5, s. 2595-2607Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The majority of modern treatment methods for malignant brain tumors are not sufficiently effective, with a median survival time varying between 9 and 14 months. Metastatic and invasive processes are the principal characteristics of malignant tumors. The most important pathogenic mechanism is epithelial-mesenchymal transition (EMT), which causes epithelial cells to become more mobile, and capable of invading the surrounding tissues and migrating to distant organs. Transforming growth factor-beta 1 (TGF-beta 1) serves a key role in EMT-inducing mechanisms. The current study presented the interaction between hematopoietic stem cells and glioblastoma cells stimulated by TGF-beta 1 in vitro. The materials for the study were hematopoietic progenitor cell antigen CD34(+) hematopoietic stem cells (HSCs) and U87 glioblastoma cells. Cell culture methods, automated monitoring of cell-cell interactions, confocal laser microscopy, flow cytometry and electron microscopy were used. It was demonstrated that U87 cells have a complex communication system, including adhesive intercellular contacts, areas of interdigitation with dissolution of the cytoplasm, cell fusion, communication microtubes and microvesicles. TGF-beta 1 affected glioblastoma cells by modifying the cell shape and intensifying their exocrine function. HSCs migrated to glioblastoma cells, interacted with them and exchanged fluorescent tags. Stimulation of cancer cells with TGF-beta 1 weakened the ability of glioblastoma cells to attract HSCs and exchange a fluorescent tag. This process stimulated cancer cell proliferation, which is an indication of the ability of HSCs to 'switch' the proliferation and invasion processes in glioblastoma cells.

  • Disputas: 2018-11-09 09:00 N440, Naturvetarhuset, Umeå
    Vikström, Kevin
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och geovetenskap.
    Importance of bacterial maintenance respiration and baseline respiration for development of coastal hypoxia2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Reduced oxygen concentrations and increasing hypoxic zones havebecome more common in the sea due to climate change andeutrophication. The main cause of oxygen loss in oxygenatedenvironments is respiration. Respiration rates can be estimated usingoptode methodologies which utilize dynamic luminescence quenching toestimate the oxygen concentration declines in dark incubations. Apublished optode methodology was improved by using optodes withtitanium housing instead of plastic housing plausibly trapping oxygen.Drift was highly reduced by the titanium casings leading to a higherprecision and lower detection limit of 0.97 mmol O2 m-3 d-1. 28% ofmeasurements were shown to have non-linear oxygen concentrationdeclines. The rate of oxygen change was derived with a 2nd degreepolynomial at 1 hour from the incubation start. The majority of non-lineardeclines were concave and due to carbon substrate limitation. Analyzingnon-linear trends linearly, a common practice, leads to anunderestimation of respiration by up to 64%.

    Bacterial maintenance respiration (Rm) was studied using anecophysiological model unverified in natural environments. The modelwas applicable at high productivities but a quadratic model wasdemonstrated to give a better fit. Rm was found to represent a significantpart in the sub-arctic estuary contributing to 58% of the annual specificbacterial respiration. Therefore, Rm may be more important in nature thanpreviously recognized. The ecophysiological model is driven solely by thebacterial specific growth rate (μ) where the relative influence of Rm iselevated as μ decreases. As a consequence, I hypothesize that a reductionin nutrients may not decrease the oxygen consumption but rather shiftbacterial growth based respiration to Rm as μ approaches zero.Baseline respiration (Rbl), defined as ecosystem respiration disconnectedfrom contemporary primary produced carbon, was also studied. Rbl wasshown to be largely supplied by allochthonous carbon in a coastalecosystem and had a contribution of 50% to the annual planktoncommunity respiration in the sub-arctic estuary studied. I claim that Rbland Rm are crucial to include for understanding and managingdevelopment of aquatic hypoxia in an effective and economic manner.

  • Disputas: 2018-11-09 09:00 Aulan, Vårdvetarhuset, Umeå
    Lundell, Sara
    Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Fysioterapi.
    COPD in primary care: exploring conditions for implementation of evidence-based interventions and eHealth2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Chronic obstructive pulmonary disease (COPD) is a major public health problem. Symptoms and comorbidities associated with COPD affect the whole body. Clinical guidelines for COPD recommend pulmonary rehabilitation (PR) including exercise training and education promoting self-management strategies. Despite the positive effects on health status, few people with COPD have access to PR. Electronic health (eHealth) has been seen as promising for increased access to evidence-based interventions. To increase the likelihood of a successful implementation, it is important to identity enablers and barriers that might affect implementation outcomes. The aim of this thesis is to explore the experiences, interactions and contexts of the management of COPD in primary care, as well as the design, experienced relevance, effect and expected usefulness of eHealth solutions.

    The thesis is based on four papers that have used qualitative, quantitative and mixed methods. Qualitative interviews (papers I, II, IV) and focus group discussions (paper IV) were analysed using qualitative content analysis (papers I, IV) and grounded theory (paper II). Quantitative data, collected using questionnaires (paper I) and in a systematic review (paper III) was analysed with descriptive statistics (paper I) and meta-analysis (paper III). The qualitative and quantitative findings in paper I and II were merged in a mixed methods design. Participants in the studies included healthcare professionals (papers I, IV), people with COPD (papers II, III, IV), their relatives (paper IV), senior managers representing primary care centres (paper I), and external researchers (paper IV).

    The findings in this thesis gave insight in the complex interactions within COPD management between the healthcare organisation (e.g. resources and priority), healthcare professionals (e.g. attitudes, collaboration and competence) and people with COPD (e.g. emotions, attitudes and coping). The healthcare organisation is fragmented with few resources and COPD care takes low priority. The healthcare professionals are Building COPD care on shaky ground (paper I), where the shaky ground is a presentation of the non-compliant organisation and other challenging circumstances. Driven, responsible and ambitious healthcare professionals wish to provide empowering COPD interventions through interprofessional collaboration, but are inhibited by their limited knowledge of and experience with COPD. People with COPD are (Re)acting in an ambiguous interaction with primary care providers (paper II), have limited knowledge and struggle with stigma, while they try to accept and manage their disease. The attitudes and support of healthcare professionals’ are essential for necessary interaction and self-management strategies. For people with COPD, this can take different paths: either enhancing confidence with empowering support or coping with disempowering stigma and threat.

    eHealth solutions such as telehealth, have been used to provide interventions to people with COPD through phone calls, websites or mobile phones, in combination with exercise training and/or education. They show a significant effect on physical activity level, but not on physical capacity and dyspnoea (paper III). Healthcare professionals, people with COPD and their relatives, and external researchers report that, to be useful and relevant in clinical practice, an eHealth tool should be reinforcing existing support structures (paper IV). Furthermore, it needs to fit in the current routines and contexts and create a sense of commitment in its users. According to the participants, information about selfmanagement strategies, such as how-to videos are valuable, and need to help them identify themselves with the people in the videos. The participants regard eHealth as providing knowledge and support for self-management.

    In conclusion, there is a need for implementation of clinical guidelines for COPD in primary care in order to improve both the management of COPD, as well as the interaction between healthcare professionals and people with COPD. Several actions are needed to facilitate this implementation. The priority and status of COPD management in primary care need to be raised. In addition, more resources (e.g. healthcare professionals) for COPD interventions is required to enhance the conditions for interprofessional collaboration and patient participation. Furthermore, it is important to include physiotherapists in COPD management, considering the focus on exercise training and physical activity. Healthcare professionals in primary care need further training and more time to educate and empower people who have COPD. The use of eHealth may lead to improvements in patient outcomes, although more research on web-based interventions is required. User involvement in the development process of an eHealth tool increases its usefulness and relevance in clinical practice and everyday life. The findings from this thesis may guide implementation processes in primary care, as well as the development of eHealth tools for people with COPD or other long-term conditions.

  • Disputas: 2018-11-09 09:00 Hörsal D Unod T9, Umeå
    Maquibar Landa, Amaia
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa. University of the Basque Country UPV/EHU.
    An insight into institutional responses to intimate partner violence against women in Spain2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Background

    Intimate Partner Violence (IPV) has been widely acknowledged as a major public health issue and a human rights concern. The international burden of this type of violence have lead countries to develop institutional responses to address the consequences for women as well as to reduce its prevalence. With this aim, the Spanish government enacted in 2004 one of the most comprehensive laws in the world. Among all sectors, the role of health care professionals in the identification, management and prevention of IPV becomes essential. Thus, this thesis analyses institutional responses to intimate partner violence against women in Spain, focusing on the public health-care sector.

    Methods

    This thesis is based on three qualitative papers and one mixed methods paper. Data collection was conducted through in-depth interviews in the two first papers, documentary review and in-depth interviews in the third paper and focus groups in the fourth paper. In the first paper I used thematic analysis to explore the perceptions of professionals working in different sectors regarding institutional responses to IPV with special attention to prevention campaigns aimed at young people. In the second paper we used grounded theory to develop a conceptual model representing the diverse responses generated when attempting to integrate a response to IPV into a biomedical health system. The third paper mapped and explored the training in IPV that nursing students receive at the undergraduate level in Spain through the revision of public documents and individual in-depth interviews. The fourth paper explored nursing students’ perceptions of, and attitudes towards, IPV after having received specific training in the topic.

    Main findings

    One of the main findings in Paper I was that the sustainability of programmes to address IPV was always jeopardized by politicians and colleagues that did not considered that IPV should be prioritized. Concerning prevention campaigns, participants in that study perceived that they sent messages that did not fit young people’s needs and thus were ineffective. Besides, they stressed that institutional responses failed to focus on on men to discourage violence. The main finding of Paper II was the coexistence of a range of responses in the health sector that included avoidance, voluntariness, medicalization and comprehensiveness. Attitudes and beliefs of health-care professionals about IPV were strongly related with the development of this variety of responses. In relation with training (Paper III), the majority of nursing training programmes in the country have incorporated IPV training in their curricula. However, there was a great variability between universities in the topics included in the training. Which topics were included in the training programme was influenced by lecturers’ perceptions of IPV. Nursing students who have received training on IPV (Paper IV) showed an increased acknowledgement of IPV as a health issue and consequently considered that early identification of IPV and referral were part of their nursing role. However, readiness to act was limited by persistence of myths around IPV as believing false accusations of IPV being widespread.

    Conclusions

    Policies enacted with the aim of reducing IPV and its consequences in Spain have been essential for initiating institutional responses to IPV, specifically in the health sector. However, responses have been weakly institutionalized so far, favouring front line workers or ‘street level bureaucrats’ exercise of discretion. This leads to inequalities between and within regions in the country in the implementation of the policies. The most relevant element influencing the use of discretion in the case of IPV responses was the understanding of the relationships between gender inequities and IPV. The predominant gender regime of the institutions responsible for policy implementation influenced political and economic support for the development of responses to IPV.

  • Disputas: 2018-11-09 13:00 Hörsal N360, Naturvetarhuet, Umeå
    Carlborg, Markus
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för tillämpad fysik och elektronik.
    Refractory corrosion in biomass gasification2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    To stop the net emission of CO2 to the atmosphere, we need to reduce our dependency of fossil fuels. Although a switch to a bio-based feedstock hardly can replace the total amount of fossils used today, utilization of biomass does still have a role in a future in combination with other techniques. Valuable chemicals today derived from fossils can also be produced from biomass with similar or new technology. One such technique is the entrained flow gasification where biomass is converted into synthesis gas. This gas can then be used as a building stone to produce a wide range of chemicals.

    Slagging and corrosion problems are challenges presented by the ash forming elements in biomass during thermochemical energy conversion. The high temperature in the entrained flow process together with ash forming elements is creating a harsh environment for construction materials in the reactor. Severe corrosion and high wear rates of the lining material is a hurdle that has to be overcome to make the process more efficient.

    The objective of this work is to investigate the nature of the destructive interaction between ash forming elements and refractory materials to provide new knowledge necessary for optimal refractory choice in entrained flow gasification of woody biomass. This has been done by studying materials exposed to slags in both controlled laboratory environments and pilot scale trials. Morphology, elemental composition and distribution of refractories and slag were investigated with scanning electron microscopy and energy dispersive X-ray spectroscopy. Crystalline phases were investigated with X-ray diffraction, and thermodynamic equilibrium calculations were done in efforts to explain and make predictions of the interaction between slag and refractory.

    Observations of slag infiltration and formation of new phases in porous materials indicate severe deterioration. The presence of Si in the materials is limiting intrusion by increasing the viscosity of infiltrated slag. This is however only a temporary delay of severe wear considering the large amount of slag that is expected to pass the refractory surface. Zircon (or zirconium) (element or mineral?) based material show promising properties when modeled with thermodynamic equilibrium, but disassembling of sintered material and dissociation of individual grains was seen after exposure to a Si- and Ca-rich slag. Fused cast materials have a minimal slag contact where the only interaction is on the immediate hot face. Dissolution was however observed when exposed to a silicate-based slag, as was the formation of NaAlO2 after contact with black liquor.

  • Disputas: 2018-11-09 13:15 Lecture Hall C, Social Sciences building, Umeå University, Umeå
    Rosales, Virginia
    Umeå universitet, Samhällsvetenskapliga fakulteten, Handelshögskolan vid Umeå universitet, Företagsekonomi.
    The interplay of roles and routines: Situating, patterning, and performances in the emergency department2018Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    This thesis took its point of departure in the lack of research regarding the intricate and important relationship between roles and routines. With roles and routines providing individuals with enough discretion to accomplish work while ensuring consistency, the overall research question posed was: how do roles and routines interplay to enable flexible performances? This question was operationalized through three sub questions: (1) why are roles and routines flexible, (2) how do roles and routines interplay, and (3) what contextual aspects influence which patterns come into play? The purpose was to increase the understanding of the interplay of roles and routines in organizations.

    The theoretical basis was built up in three steps. First, the foundations of roles and routines were explored separately, laying the basis for further conceptualizations. Second, overlaps of role and routine studies were explored, highlighting their contributions to current understandings. Third, through a joint discussion of the fields, commonalities between the two areas were put forth. Central to this were the ontological foundations in performances, and re-enacting the duality of structure and agency. The theoretical work resulted in a conceptual framework, which integrated roles and routines and served as the basis for unpacking and furthering an understanding of their interplay.

    In order to fulfil the purpose, and in line with the view on roles and routines as patterns of action, an organizational ethnography of an emergency department at a Swedish university hospital was conducted. Due to its characteristics, this setting represented a unique opportunity to study the interplay. Primarily based on observations, a total of 25 field visits (136,5 hours), 19 interviews, and hundreds of documents, served as the empirical material, which was analysed through iterative rounds of coding. Narratives, visual mapping, and narrative networks, were analytical strategies used in progressively moving from an understanding of the context to the identification of role and routine patterns.

    Furthering the developed conceptual framework, the findings showed how roles and routines interplay in, and through, performances. Depending on individual, interpersonal, and environmental aspects, scripted and unscripted patterns are situated in performances, which trigger role and routine patterning. Summarized in an integrated framework, which highlights the key findings, this thesis showed how the interplay of roles and routines provides organizations with stability and flexibility. This has implications not only for role and routine theories, but also organization theory in general. Implications, regarding the organizing of work at emergency departments, and other organizations, as well as for educators, the society and governments were also outlined.

  • Disputas: 2018-11-09 10:00 S 213, Samhällsvetarhuset, Umeå
    Palmadottir, Valgerdur
    Umeå universitet, Humanistiska fakulteten, Institutionen för idé- och samhällsstudier.
    Perplexities of the personal and the political: how women's liberation became women's human rights2018Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    In this dissertation, I analyze understandings and employment of the idea that ‘the personal is political’ and how it appears in feminist politico-theoretical thought and activism in the period from the late 1960s until the middle of 1990s. My focus is primarily on the uses of personal stories in activism at the intersections of politics and legal discourse. The period in question is characterized by an evolving global feminist movement that gradually turned towards the framework of human rights. I explore two events that took place on either side of the human rights turn. These events are two international People’s Tribunals and their respective theoretical and historical contexts. The two tribunals were outspoken feminist initiatives, one held in Brussels in 1976 and the other in Vienna in 1993. They were organized by different actors at different historical moments who nevertheless identified themselves as being participants in a common international or global women’s movement. Their common denominator was both the choice of the form of a people’s tribunal and their aim of transcending national borders. Yet, their frameworks and language differ significantly.

    The first tribunal, Crimes against Women, held in Brussels in 1976, was planned as a radical feminist grassroots event, an upfront and critical response in opposition to the United Nations Conference on Women held in Mexico in 1975. In Brussels, feminist consciousness raising was fused with the method of a people’s tribunal to contribute to the creation of a transnational feminist political subject. Testimonies included personal stories of oppression and sexual violence, and they were meant to educate and motivate the women themselves in their struggle. There were no judges involved in the ‘trial’ procedures because the organizers and participants claimed that women had had enough of being judged by a patriarchal society. The event was for women only and no media were allowed to attend. Inspired by the tribunal in Brussels, the Vienna Tribunal on Women’s Human Rights, however, was planned in relation to the UN’s Conference on Human Rights in 1993, with the conceptual framework “Women’s Rights are Human Rights.” Testimonies were now directed outwardly, and strategically-selected judges commented and promised to offer support for the campaign to include gender-based violence in the human rights framework.

    My analytical focus is on three interrelated and overarching threads. Firstly, I identify ideas about politics found in the tribunal texts and the theoretical contexts that I place them in. Secondly, I trace the genealogy of violence against women as an international political issue. This converges with the history of transnational feminist activism, the rise of the human rights discourse and the search for common denominators. Thirdly, I look at the affective dimensions of the personal story as a political mobilizer. I argue that they change significantly according to historical, institutional and theoretical (ideological) context.

    Although the strategy of using personal testimonies might at first sight seem to be the greatest similarity that links the two events, the ‘method’ underwent some significant changes. I argue that the focus in Brussels was on creating a ‘counter-public’, to cultivate the participant’s own political emotions, notably righteous anger and to forge transnational feminist consciousness and solidarity, whereas, in Vienna, the framework had a more strategic character, as the individual stories were aimed at personalizing the political and motivating the empathy or compassion of an audience. 

     

  • Larsson, Gunilla
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen. Samelands fria universitet.
    Ett par utspända stockbåtar från Roslagen2009Inngår i: Rospiggen, nr 69Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • Larsson, Gunilla
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen. Samelands fria universitet.
    Kvinnor till sjöss under vikingatid2010Inngår i: Rospiggen, nr 70Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • Johansson, Lars-Göran
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Filosofiska institutionen, Avdelningen för teoretisk filosofi.
    Induction and Epistemological Naturalism2018Inngår i: Philosophies, ISSN 2409-9287, Vol. 3, nr 4, artikkel-id 31Artikkel i tidsskrift (Fagfellevurdert)
  • Jiao, Mingzhi
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Mikrosystemteknik.
    Nguyen Viet, Chien
    Hanoi University of Science and Technology.
    Duy, Nguyen Van
    Hanoi University of Science and Technology.
    Nguyen Duc, Hoa
    Hanoi University of Science and Technology.
    Hieu, Nguyen Van
    Hanoi University of Science and Technology.
    Hjort, Klas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Mikrosystemteknik.
    Nguyen, Hugo
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Mikrosystemteknik.
    Influence of annealing temperature on theperformance and stability of on-chip hydrothermally grown ZnO nanorod gassensor toward NO22018Inngår i: Academia Journal of Scientific Research, ISSN 2315-7712, Vol. 6, nr 5, s. 180-189Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Nanorod-based gas sensors synthesized at low temperature should generally be stabilized by anneling before usage. However, the influence of annealing on the sensing performance and stability of these nanorods is rarely reported. In this study, we first fabricated gas sensors based on ZnO nanorods grown on-chip on glass substrate using hydrothermal method. Subsequently, these sensors were annealed at either 400 °C, 500 °C, or 600 °C in air for 4 h. The gas-sensing performance of the ZnO nanorods toward NO2 was tested before and after annealing. The sensitivity of the gas sensors to NO2 decreased, but the stability increased with the increase in annealing temperature. Photoluminescence spectroscopy and X-ray diffraction were used to investigate the material structure of ZnO nanorods. Results revealed that the oxygen-atom-related defects in the ZnO lattice in the region close to the surface influenced by annealing process were the most significant factors on the sensing properties and stability of ZnO nanorods.

  • Farrell, W. M.
    et al.
    NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
    Hadid, Lina Z
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutet för rymdfysik, Uppsalaavdelningen.
    Morooka, Michiko
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutet för rymdfysik, Uppsalaavdelningen.
    Kurth, W. S.
    Univ Iowa, Dept Phys & Astron, Iowa City, IA 52242 USA.
    Wahlund, Jan-Erik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutet för rymdfysik, Uppsalaavdelningen.
    MacDowall, R. J.
    NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
    Sulaiman, A. H.
    Univ Iowa, Dept Phys & Astron, Iowa City, IA 52242 USA.
    Persoon, A. M.
    Univ Iowa, Dept Phys & Astron, Iowa City, IA 52242 USA.
    Gurnett, D. A.
    Univ Iowa, Dept Phys & Astron, Iowa City, IA 52242 USA.
    Saturn's Plasma Density Depletions Along Magnetic Field Lines Connected to the Main Rings2018Inngår i: Geophysical Research Letters, ISSN 0094-8276, E-ISSN 1944-8007, Vol. 45, nr 16, s. 8104-8110Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We report on a set of clear and abrupt decreases in the high-frequency boundary of whistler mode emissions detected by Cassini at high latitudes (about +/- 40 degrees) during the low-altitude proximal flybys of Saturn. These abrupt decreases or dropouts have start and stop locations that correspond to L shells at the edges of the A and B rings. Langmuir probe measurements can confirm, in some cases, that the abrupt decrease in the high-frequency whistler mode boundary is associated with a corresponding abrupt electron density dropout over evacuated field lines connected to the A and B rings. Wideband data also reveal electron plasma oscillations and whistler mode cutoffs consistent with a low-density plasma in the region. The observation of the electron density dropout along ring-connecting field lines suggests that strong ambipolar forces are operating, drawing cold ionospheric ions outward to fill the flux tubes. There is an analog with the refilling of flux tubes in the terrestrial plasmasphere. We suggest that the ring-connected electron density dropouts observed between 1.1 and 1.3 R-s are connected to the low-density ring plasma cavity observed overtop the A and B rings during the 2004 Saturn orbital insertion pass.

    Plain Language Summary We present Cassini observations during the close passes by the planet Saturn indicating that plasma on magnetic field lines that pass through the A and B rings is of anomalously low density. These observations are consistent with the Saturn orbit insertion observations of a plasma cavity located at equatorial regions overtop the dense B ring. Using a terrestrial analogy, we suggest that the low-density conditions overtop the rings create an electrical force, called an ambipolar electric field that draws plasma out of the ionosphere in an attempt to replenish the plasma void found at equatorial regions.

  • Radonjic, Andja
    et al.
    Univ Belgrade, Fac Agr, Zemun Belgrade, Serbia;Swedish Univ Agr Sci, Dept Ecol, Box 7044, S-75007 Uppsala, Sweden.
    Terenius, Olle
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi. Swedish Univ Agr Sci, Dept Ecol, Box 7044, S-75007 Uppsala, Sweden.
    Ninkovic, Velemir
    Swedish Univ Agr Sci, Dept Ecol, Box 7044, S-75007 Uppsala, Sweden.
    The phytopathogen powdery mildew affects food-searching behavior and survival of Coccinella septempunctata2018Inngår i: Arthropod-Plant Interactions, ISSN 1872-8855, E-ISSN 1872-8847, Vol. 12, nr 5, s. 685-690Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The diet of entomophagous coccinellids is mainly based on aphids and other food sources such as pollen, nectar, or fungal spores. Knowledge of their foraging behavior on plants infected by powdery mildew and their survival on fungal spores is currently limited. In this study, we investigated the olfactory response of Coccinella septempunctata to odor emission of barley plants infected by powdery mildew and their survival on fungal spores in the presence or absence of aphids. Odors released by powdery-mildew infected plants were more attractive for ladybirds compared to those of uninfected controls. After 3days, the survival rate of ladybirds feeding only on powdery-mildew spores was less than 50%, while for ladybirds feeding exclusively on Rhopalosiphum padi aphids, the survival rate was close to 90%. After 15days, the highest survival rate (almost 80%) was observed for ladybirds feeding on plants with both aphids and powdery mildew. Molecular analyses confirmed the presence of fungal spores in ladybird guts when feeding either on powdery mildew or on a mixed diet. Our results provide new insights into foraging behavior of entomophagous coccinellids revealing the potential of powdery mildew to be utilized as important non-essential food in a mixed diet, but also its lethal effect if consumed alone.

  • Babri, Maira
    Samhällsvetenskapliga fakulteten, Umeå universitet, Umeå.
    The Corporate Code of Ethics at Home, Far Away and in Between: Sociomaterial Translations of a Traveling Code2016Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    Corporate codes of ethics (CCEs) have become increasingly prevalent as overarching ethical guidelines for multinational corporations doing business around the globe. As formal documents, governing corporations’ work, policies, and ways of doing business, CCEs are meant to guide all business activities and apply to all of the corporation’s employees, suppliers, and business partners. In multinational corporations, this means that diverse countries, cultures, and a myriad of heterogeneous actors are expected to abide by the same standards and guidelines, as stipulated in the CCE. Despite this empirical reality, CCEs have previously been approached by academics mainly as passive company documents or as marketing or management tools, in the contexts of their country of origin. Building on Actor-Network Theory this thesis applies an interactionist ontology, and relational epistemology, seeing the code as a sociomaterial object with both material and immaterial characteristics, and moving in a global arena. Furthermore, the CCEs are assumed to be susceptible to change, i.e. translations. With these assumptions, the CCE of a multinational corporation is followed as it travels between its country of origin (Sweden) and another country (China) and goes to work in different contexts. Heterogeneous empirical materials such as interviews, company documents, observations, shadowing, and emails are used to present stories from different contexts where the CCE is at work. The overall purpose of the thesis is to contribute to the theorizing of CCEs, thereby providing further understanding of the possible consequences of CCEs in contextually diverse settings. By following traces of a CCE, this study posits the need for a simultaneous understanding of three dimensions of CCEs for CCEs to be understood in contextually dispersed settings. The three dimensions are a) material translations of the code, b) enactments of these translations, and c) ideas associated with the material and enacted code.  The study contributes to the understanding of CCEs by highlighting a specific country-context (China), by putting together knowledge from codes in various contexts, and the overarching contribution lies in highlighting codes as different kinds of objects and adding to the existing literature – specifically, contextualizing the CCE as a vaporous object.

  • Horio, M.
    et al.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Matt, C. E.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland;Harvard Univ, Dept Phys, Cambridge, MA 02138 USA;Paul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland.
    Kramer, K.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Sutter, D.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Cook, A. M.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Sassa, Yasmine
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Hauser, K.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Mansson, M.
    KTH Royal Inst Technol, Dept Appl Phys, Electrum 229, SE-16440 Stockholm, Sweden.
    Plumb, N. C.
    Paul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland.
    Shi, M.
    Paul Scherrer Inst, Swiss Light Source, CH-5232 Villigen, Switzerland.
    Lipscombe, O. J.
    Univ Bristol, HH Wills Phys Lab, Bristol BS8 1TL, Avon, England.
    Hayden, S. M.
    Univ Bristol, HH Wills Phys Lab, Bristol BS8 1TL, Avon, England.
    Neupert, T.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Chang, J.
    Univ Zurich, Phys Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
    Two-dimensional type-II Dirac fermions in layered oxides2018Inngår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, artikkel-id 3252Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Relativistic massless Dirac fermions can be probed with high-energy physics experiments, but appear also as low-energy quasi-particle excitations in electronic band structures. In condensed matter systems, their massless nature can be protected by crystal symmetries. Classification of such symmetry-protected relativistic band degeneracies has been fruitful, although many of the predicted quasi-particles still await their experimental discovery. Here we reveal, using angle-resolved photoemission spectroscopy, the existence of two-dimensional type-II Dirac fermions in the high-temperature superconductor La1.77Sr0.23CuO4. The Dirac point, constituting the crossing of d(x2-y2) and d(z2) bands, is found approximately one electronvolt below the Fermi level (E-F) and is protected by mirror symmetry. If spin-orbit coupling is considered, the Dirac point degeneracy is lifted and the bands acquire a topologically non-trivial character. In certain nickelate systems, band structure calculations suggest that the same type-II Dirac fermions can be realised near EF.

  • Säfstrom, Emma
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Linkoping Univ, Dept Med & Hlth Sci, Div Nursing Sci, Linkoping, Sweden; Nykoping Hosp, Sormland Cty Council, Nykoping, Sweden.
    Jaarsma, Tiny
    Linkoping Univ, Dept Social & Welf Studies, Linkoping, Sweden.
    Stromberg, Anna
    Linkoping Univ, Dept Med & Hlth Sci, Div Nursing Sci, Linkoping, Sweden;Linkoping Univ, Dept Cardiol, Linkoping, Sweden.
    Continuity and utilization of health and community care in elderly patients with heart failure before and after hospitalization2018Inngår i: BMC Geriatrics, ISSN 1471-2318, E-ISSN 1471-2318, Vol. 18, artikkel-id 177Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The period after hospitalization due to deteriorated heart failure (HF) is characterized as a time of high generalized risk. The transition from hospital to home is often problematic due to insufficient coordination of care, leading to a fragmentation of care rather than a seamless continuum of care. The aim was to describe health and community care utilization prior to and 30 days after hospitalization, and the continuity of care in patients hospitalized due to de novo or deteriorated HF from the patients' perspective and from a medical chart review. Methods: This was a cross-sectional study with consecutive inclusion of patients hospitalized at a county hospital in Sweden due to deteriorated HF during 2014. Data were collected by structured telephone interviews and medical chart review and analyzed with the Spearman's rank correlation coefficient and Chi square. A P value of 0. 05 was considered significant. Results: A total of 121 patients were included in the study, mean age 82.5 (+/- 6.8) and 49% were women. Half of the patients had not visited any health care facility during the month prior to the index hospital admission, and 79% of the patients visited the emergency room (ER) without a referral. Among these elderly patients, a total of 40% received assistance at home prior to hospitalization and 52% after discharge. A total of 86% received written discharge information, one third felt insecure after hospitalization and lacked knowledge of which health care provider to consult with and contact in the event of deterioration or complications. Health care utilization increased significantly after hospitalization. Conclusion: Most patients had not visited any health care facility within 30 days before hospitalization. Health care utilization increased significantly after hospitalization. Flaws in the continuity of care were found; even though most patients received written information at discharge, one third of the patients lacked knowledge about which health care provider to contact in the event of deterioration and felt insecure at home after discharge.

  • Emanuel, Martin
    Conny Kullman, interview from 2017/20182018Dataset
    Abstract [en]

    The interview treats Conny Kullman’s experiences from space-related work, first at Saab Space in Gothenburg and later from his career within Intelsat. Kullman describes the Gothenburg department of Saab Space—where he worked as a system design engineer, designing and testing on board computer models for the Ariane launcher and a number of European satellites—as relatively independent from the Linköping main office. Coming to Intelsat as a systems engineer in 1986, during the 1990s Kullman advanced within the organization and held management positions with responsibility for Systems Operation, Systems Planning, as Chief Information Officer, and as Vice President for all operation as well as Engineering. In 1998 he became CEO of Intelsat and embarked on a three-tiered program: to privatize Intelsat, to make an IPO, and to have Intelsat develop a ground infrastructure for satellite communication. In the interview, Kullman elaborates on the organizational structure of Intelsat, an “intergovernmental cooperative” as he calls it, and how this structure, having been a strength in the early days, in his view became a major weakness. As fibre optics began to provide a cheap alternative to satellite telecommunication, and with the development of competing satellite communication systems, the treaty-based regulations as well as the interests of the largest Signatories (owners) of Intelsat, not least American Comsat and British Telecom, impeded sound operation from a business point of view. The interview treats in detail Kullman’s role in and insights from the privatization process, the transition in ownership in 2005, when Intelsat was bought by private equity firms, as well as Intelsat’s acquisition of Loral (2003) and PanAmSat (2006).

  • Hedlin, Maria
    et al.
    Linnéuniversitetet.
    Åberg, Magnus
    Karlstads universitet.
    Fallet med de störande manliga studenterna: en situation tolkad utifrån fyra olika förklaringsmodeller2015Inngår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 9, nr 1, s. 116-133Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this article, we use a situation in a teacher education program as the basis to problematize different understandings of ”feminine” and ”masculine”. Within the program, the arrogant and condescending behavior of a group of male student teachers towards their female classmates was discussed. The men were oriented towards each other in a manner that excluded women. They demonstrated their disinterest in the seminars and they disturbed the on-going education. A group of teacher educators considered an explanation for the male students’ behavior, saying that because the men were in a program with predominantly female students and many female teachers, they were supposed to have a natural need to socialize with each other and to underscore that they were men. They would therefore need to assert themselves and rebel against the women within the program. In this article we will discuss this explanation, as well as a sex-role explanation, an individual-oriented explanation and finally an explanatory model that draws on critical masculinity studies. By situating these explanations in time and space, we show how knowledge from the field of gender studies can increase the likelihood that teacher education is a place of equal participation and inclusion.

  • Elvstrand, Helene
    Linköpings universitet.
    Att göra delaktighet i skolan - elevers erfarenheter2015Inngår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 9, nr 1, s. 102-115Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article examines the practice of pupils’ participation in school with a focus on pupils’ own experiences. According to UNCRC, it is important to study pupils’ own experiences, both from a children’s rights perspective, and with a view to learning about democratic processes in school. The empirical data in the article are drawn from a two-year field study among 10- to 12-year-old pupils in their classrooms. The data consist of field notes, interviews, and drawings and essays produced by the pupils. The result shows that informal participation was the most common democratic form where the pupils and teachers negotiated for influence through different processes. These processes are intertwined and take place through interaction. The result also shows that participation is a privilege that pupils must earn in some way, for example by behaving well. Further on, pupils’ participation can also be understood as an individualized process where some pupils have a lot influence and others have only limited influence. Finally, from the pupils’ perspective, it is important that the democratic processes in the classroom be comprehensible and visible, which creates a sense of trust.

  • Andersson, Erik
    et al.
    Högskolan i Skövde.
    Sandgren, Susanne
    Skaraborgs Kommunalförbund.
    Delaktighet som pedagogik och demokratiskt värde för fullföljandet av studier - kunskapsbidrag från ett utvecklingsprojekt2015Inngår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 9, nr 1, s. 80-100Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Participation as a pedagogy and democratic value turns out to be a critical element in students’ completion of school. Completed education is a regional development project in which a survey has been conducted in order to identify successful strategies to promote completed education in school. In an analysis, in the context of the survey, with an emphasis on school and participation as a pedagogy and democratic value, several findings are shown. It turns out that the importance of participation manifests itself through an emphasis on the societal and democratic mission of school; school ethos; the value praxis of school; pedagogical approach; and viewing the pupil as capable. It is, in more detail, shown that it is particularly crucial to understand the completion of education in school as a pedagogical problem; create sustainable institutional structures not bound to one person; and to make sure that students are participants in their own education.

  • Disputas: 2018-11-30 12:30 Senaatzaal, Delft
    Gorenstein Dedecca, João
    KTH, Skolan för elektroteknik och datavetenskap (EECS).
    Expansion Governance of the Integrated North Seas Offshore Grid2018Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    The expansion of offshore power transmission and generation in the North Seas of Europe is accelerating rapidly. This is due to several drivers, including the decarbonization and reform of the European power system, and innovations in offshore wind and high-voltage direct current transmission. So far, this European North Seas offshore grid is composed of conventional transmission lines, which perform the interconnection of onshore power systems and the wind farm connection functions separately. An integrated offshore grid is an innovative concept where some of the transmission lines perform simultaneously both the interconnection and connection functions. Earlier research leveraging optimization approaches already demonstrated that such an integrated offshore grid can provide socio-economical, technical and environmental benefits.

    The offshore grid is characterized by its multiplicity of actors, working in several levels, from the European to the sub-national. This makes governance the only adequate decision-making mode to manage the grid expansion towards more integration. Governance combines hierarchies, markets and networks in order to guide decision-making in a networked multi-level, multi-actor system. The expansion governance of the offshore grid can be analyzed according to six building blocks: meta-governance, planning, financing, ownership, pricing and operation. Previous studies have identified important barriers in these building blocks for the development of an integrated offshore grid. These comprise the difficulties in the site planning and development of integrated projects, the allocation of costs and benefits among actors, and the compatibilization of national support schemes to offshore wind.

    This research applies an exploratory approach to expansion governance to understand how the offshore grid can be managed towards more integration in the presence of these barriers. Therefore, it does not prescribe investments in specific offshore wind farms and transmission corridors. This approach combines energy systems modeling and regulatory analysis to focus on the management of investments in offshore assets, which are central to developing an integrated grid.

    The Offshore Grid Exploratory Model (OGEM) was developed in this thesis to endogenously represent integrated governance barriers: the complexity of planning integrated lines and the interests of individual North Seas countries. OGEM confirms that an integrated offshore grid is beneficial to Europe. However, these benefits are highly dependent on the e-Highway2050 scenarios used, and asymmetrically distributed between countries and actor groups. Governance barriers (represented as model constraints) lead to a modest reduction in benefits, and do not change the distribution asymmetry.

    The impact of the barriers is more pronounced regarding investment changes in transmission technologies and integrated lines. They increase path dependence and hinder the deployment of multiterminal HVDC lines. Also, the location and potential of offshore wind interacts with investments in offshore transmission, both of which can change radically in the presence of governance barriers.

    The impact of these barriers on the offshore expansion pathways allows to recommend design principles for governance frameworks of offshore investments. These comprise the need for: a comprehensive expansion candidate portfolio including both non-integrated multiterminal HVDC and integrated projects; to consider the interrelation of expansion periods in planning; and to consider different rates of innovation for transmission technologies.

    In parallel, the Clean Energy Package is analyzed for the changes they bring to the European regional governance of offshore expansions. Five challenges are identified. The first two deal with the interaction of the governance structure of the European and national levels with the regional one. Then, the third challenge deals with the participation of the United Kingdom and Norway in the European expansion governance. On the other hand, the las two challenges concern specific governance building blocks. The planning challenge indicates that the regional planning of the offshore grid is dependent on national development plans, which in their turn must consider national interests. And the pricing and financing challenge indicates that cost allocation for Projects of Common Interest rigidly precedes the application for financing, invalidating the cost allocation in case the application is unsuccessful. Importantly, these challenges are largely unaddressed by the Energy Union reform.

    The thesis concludes with a number of policy recommendations. They concern meta-governance and the need for capacity building at the regional level. Then, multiple recommendations cover planning. Beyond following the design principles above, the planning challenge needs to be solved. Also, planning models and data should move towards open-modeling approaches which would facilitate the consideration of a broader candidate portfolio. Regarding financing and pricing, the regulation should foster more anticipatory investments than the current practice, and the Projects of Common Interest cost allocation and funding challenge should be solved. These recommendations constitute specific changes to the European expansion governance which would significantly improve the playing field for an integrated offshore grid.

  • Holmquist, Anna-Lovisa (, , , )
    Konstfack. KTH Royal Institute of Technology, Stockholm.
    FOLKFORM PRODUCTION NOVELLAS2017Kunstnerisk output (Ogranskad)
    Abstract [en]

    Through the manufacturing of Production Novellas, Folkform aim to communicate knowledge of the design production process behind objects, focusing on past industrial processes and craft techniques. The production novellas are an ongoing investigation of manufacturing traditions and old industrial processes in local contexts and craft techniques that are threatened to disappear.  The Production Novellas include momories, situations, fragments and scenes from the production process as described by the designer, through both visual and textual material. 

  • Disputas: 2018-11-09 10:15 Sydney Alrutz, Uppsala
    Forslund, Tommie
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Uppsala University, department of psychology.
    Disorganized Attachment Representations, Externalizing Behavior Problems, and Socio-Emotional Competences2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Disorganized attachment is a risk-factor for developmental maladaptation in the form of externalizing behavior problems, and for poor development of competences important for socio-emotional functioning. Concerns have however been raised regarding theoretical overextension, and there is consequently a need for multifactorial studies that examine which outcomes disorganized attachment is reliably important for. There is also a lack of research on the mechanisms that mediate the relation between disorganized attachment and externalizing problems. The present thesis therefore examined whether disorganized attachment is a specific risk-factor for symptoms of Oppositional Defiant Disorder (ODD) or Attention-Deficit/Hyperactivity Disorder (ADHD), or a non-specific risk factor for both types of problems. Several emotional and cognitive competences were investigated as mediators, with the question of whether disorganized attachment becomes associated with externalizing problems primarily through any specific mechanism, or through multiple mechanisms. Three studies were conducted. Children completed the separation anxiety test for attachment representations and laboratory tasks for distinct competences, and parents and teachers rated emotion regulation and ODD- and ADHD-symptoms. Study I was cross-sectional and found that disorganized attachment contributed specifically to conduct problems when accounting for ADHD-symptoms. However, disorganized attachment did not contribute to ADHD-symptoms when accounting for conduct problems. Study II found that children with disorganized attachment representations show deviations in identification of emotional expressions, in the form of a generally diminished ability to discriminate between expressions rather than in response biases. Study III was (short-term) longitudinal and replicated the results from Study I; disorganized attachment was primarily associated with ODD-symptoms, not ADHD-symptoms. Elevated emotional reactivity and poor regulation, particularly for anger and fear, mediated the relation between disorganized attachment and ODD-symptoms. Taken together, the present findings suggest that disorganized attachment may constitute a specific risk factor for externalizing problems pertaining to anger and aggression, such as oppositionality and misconduct, rather than ADHD-problems. Importantly, the findings caution against ideas of a pathway from disorganized attachment to ADHD-symptoms. The deviations in processing and regulation of anger and fear corroborate Bowlby´s proposal that these emotions are closely connected, central to disorganization, and a potential mediating mechanism in relation to externalizing problems.

  • Fredriksson, Maria
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Industriell teknik.
    Henningsson, Annika
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Industriell teknik.
    Flipped Classroom med gamification som stöd för studentaktiverande undervisningsform2017Konferansepaper (Annet vitenskapelig)
  • Disputas: 2018-11-15 10:00 Gard aulan, Solna
    Sjöstedt, Evelina
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi.
    Towards a deeper understanding of the human brain2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Identifying the proteome variation in different parts of the body provides fundamental molecular details, enabling further findings and mapping of tissue specific proteins. By combining quantitative transcriptomics with qualitative antibody based proteomics, the Human Protein Atlas (HPA) project aims to protein profile each human protein-coding gene. Genes with varying expression levels in the different tissue types are categorized as tissue elevated in one tissue compared to others, thus connecting genes to potential tissue specific functions. This thesis focuses on the most complex organ in the human body, the brain. With its billions of neurons specifically organized and interconnected, the ability of not only controlling the body but also responsible for higher cognitive functions, the brain is still not fully understood.

    In my search for brain important proteins, genes were classified at different stages based on expression levels. In Paper I and II the transcriptome of cerebral cortex was compared with peripheral organs to classify genes with elevated expression in the brain. Brain expression information was expanded by including external data (GTEx and FANTOM5) into the analysis, in Paper III. Thereafter, in Paper IV, the three datasets (HPA, GTEx and FANTOM5) were aligned and combined, enabling a consensus classification with an improved representation of the brain complexity. The most recent classification provided whole body gene expression profiles and out of the 19,670 protein-coding genes, 2,501 were expressed at elevated levels in the brain compared to the other tissue types. Twelve individual regions represented the brain as an organ, and were further analyzed and compared for regional classification of gene expression. One thousand genes showed regional variation in expression level, thus classified as regionally elevated within the brain. Interestingly, less than 500 of the genes classified as brain elevated on the whole body level, and were also regionally elevated in the brain. Many genes with regionally variable expression within the brain showed higher expression in a peripheral organ than in the brain when comparing whole body expression. Based on elevated expression in the brain or brain regions, more than 3,000 genes were suggested to be of high importance to the brain.

    In addition, this high-throughput approach to combine transcriptomics and protein profiles in tissues and cells further generated new knowledge in several different other aspects: better understanding of uncharacterized and “missing proteins” (Paper III), validation of an antibody improving classification of pituitary adenoma (Paper V) and in Paper VI the possibility to explore cancer specific expression in relation to clinical data and normal tissue expression.

    There are multiple diseases of the brain that are poorly understood on both a cellular and molecular level. While my work mainly focused on identifying and understanding the molecular organization of the normal brain, the ultimate goal of mapping and studying the normal expression baseline is to understand the molecular aspects of disease and identify ways to prevent, treat and cure diseases.

  • Hong, Nan-Sook
    et al.
    Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia.
    Petrovic, Dusan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Biokemi.
    Lee, Richmond
    Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia.
    Gryn'ova, Ganna
    Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia;Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland.
    Purg, Miha
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Biokemi.
    Saunders, Jake
    Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia.
    Bauer, Paul
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Biokemi.
    Carr, Paul D.
    Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia.
    Lin, Ching-Yeh
    Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia.
    Mabbitt, Peter D.
    Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia.
    Zhang, William
    Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia.
    Altamore, Timothy
    Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia.
    Easton, Chris
    Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia.
    Coote, Michelle L.
    Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia.
    Kamerlin, Shina C. Lynn
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Biokemi.
    Jackson, Colin J.
    Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia.
    The evolution of multiple active site configurations in a designed enzyme2018Inngår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, artikkel-id 3900Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. Besides creating useful catalysts, the generation and iterative improvement of designed enzymes can provide valuable insight into the interplay between the many phenomena that have been suggested to contribute to catalysis. In this work, we follow changes in conformational sampling, electrostatic preorganization, and quantum tunneling along the evolutionary trajectory of a designed Kemp eliminase. We observe that in the Kemp Eliminase KE07, instability of the designed active site leads to the emergence of two additional active site configurations. Evolutionary conformational selection then gradually stabilizes the most efficient configuration, leading to an improved enzyme. This work exemplifies the link between conformational plasticity and evolvability and demonstrates that residues remote from the active sites of enzymes play crucial roles in controlling and shaping the active site for efficient catalysis.

  • Dovemark, Marianne
    et al.
    Göteborgs universitet.
    Holm, Ann-Sofie
    Göteborgs universitet.
    Förortens skola - möjligheternas skola?2015Inngår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 9, nr 1, s. 62-78Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Loss of equivalence in Swedish education has been highlighted in both research and media. Arguably, one explanation for this is related to the free choice reform which has led to competition and homogenization of schools. In combination with peer effects and teachers’ different expectations this has led to a gap between schools in the way they adapt their marketing towards specific groups of students. Some students become more desirable than others. The polarization between “winners” and “losers” has thereby increased the importance of school selection with regards to learning outcomes and future educational life chances. This article focuses on students in Ash Public, a public upper secondary school located in a stigmatized immigrant suburb. The study is based on formal interviews, field interviews and observations, and contrary to its negative reputation, the school and its pedagogical practice were generally described in positive terms by the involved school actors. Teachers mentioned motivated and ambitious students and students described a school where they felt safe and included and where collaborative work was in focus. Ash Public proved to be a school for everyone except for “Swedes”.

  • Valdés, Alberto
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Zhao, Hongxing
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.
    Pettersson, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Lind, Sara Bergström
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Time-resolved proteomics of adenovirus infected cells2018Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 9, artikkel-id e0204522Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Viral infections cause large problems in the world and deeper understanding of the disease mechanisms is needed. Here we present an analytical strategy to investigate the host cell protein changes during human adenovirus type 2 (HAdV-C2 or Ad2) infection of lung fibro-blasts by stable isotope labelling of amino acids in cell culture (SILAC) and nanoLC-MS/MS. This work focuses on early phase of infection (6 and 12 h post-infection (hpi)) but the data is combined with previously published late phase (24 and 36 hpi) proteomics data to produce a time series covering the complete infection. As many as 2169 proteins were quantitatively monitored from 6 to 36 hpi, while some proteins were time-specific. After applying different filter criteria, 2027 and 2150 proteins were quantified at 6 and 12 hpi and among them, 431 and 544 were significantly altered at the two time points. Pathway analysis showed that the De novo purine and pyrimidine biosynthesis, Glycolysis and Cytoskeletal regulation by Rho GTPase pathways were activated early during infection while inactivation of the Integrin signalling pathway started between 6 and 12 hpi. Moreover, upstream regulator analysis predicted MYC to be activated with time of infection and protein and RNA data for genes controlled by this transcription factor showed good correlation, which validated the use of protein data for this prediction. Among the identified phosphorylation sites, a group related to glycolysis and cytoskeletal reorganization were up-regulated during infection. The results show specific aspects on how the host cell proteins, the final products in the genetic information flow, are influenced by Ad2 infection, which would be overlooked if only knowledge derived from mRNA data is considered.

  • Borglund, Tommy
    Ekonomiska forskningsinstitutet, Handelshögskolan i Stockholm, Stockholm.
    Aktieägarvärden i fokus: internationell påverkan på intressentrelationer genom förvärv och fusion2006Doktoravhandling, monografi (Annet vitenskapelig)
  • Aaboud, M.
    et al.
    Univ Mohamed Premier & LPTPM, Fac Sci, Oujda, Morocco.
    Asimakopoulou, Eleni M.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik. Georg August Univ, Phys Inst 2, Gottingen, Germany.
    Brenner, Richard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    Search for pair production of heavy vector-like quarks decaying into high-(PT) W bosons and top quarks in the lepton-plus-jets final state in pp collisions at root s=13 TeV with the ATLAS detector2018Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 8, artikkel-id 048Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A search is presented for the pair production of heavy vector-like B quarks, primarily targeting B quark decays into a W boson and a top quark. The search is based on 36.1 fb(-1) of pp collisions at root s = 13 TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Data are analysed in the lepton-plus-jets final state, characterised by a high-transverse-momentum isolated electron or muon, large missing transverse momentum, and multiple jets, of which at least one is b-tagged. No significant deviation from the Standard Model expectation is observed. The 95% confidence level lower limit on the B mass is 1350 GeV assuming a 100% branching ratio to Wt. In the SU(2) singlet scenario, the lower mass limit is 1170 GeV. The 100% branching ratio limits are found to be also applicable to heavy vector-like X production, with charge +5/3, that decay into Wt. This search is also sensitive to a heavy vector-like B quark decaying into other final states (Zb and Hb) and thus mass limits on B production are set as a function of the decay branching ratios.

  • Hjort, Mattias
    Statens väg- och transportforskningsinstitut, Trafik och trafikant,TRAF, Förare och fordon, FOF.
    Vinterdäck till cykel: ett jämförande test2018Rapport (Annet vitenskapelig)
    Abstract [sv]

    Syftet med denna studie har varit att jämföra väggreppet för olika dubbade cykeldäck, samt ett par odubbade vinterdäck, genom tester med cyklist. Utöver väggrepp så testades även andra egenskaper som kan vara viktiga för en cyklist, så som rullmotstånd och slittålighet.

    Däckens väggrepp på is testades genom bromstester och manövreringstester inomhus i en ishall. Fyra olika testförare användes för att fånga upp skillnader i förarbeteende samt för att få en variation av cyklistens vikt. Däckens rullmotstånd mättes genom utrullningsförsök inomhus. Slutligen testades väggreppet på torr och våt asfalt genom bromstester utomhus. Mellan de olika testerna så undersöktes dubbdäcken med avseende på antal tappade dubbar i syfte att utröna dubbdäckens slittålighet. Totalt testades sju olika dubbdäck, två dubbfria vinterdäck och ett sommardäck.

    Bromstesterna på torr och våt asfalt kunde inte påvisa någon skillnad i prestanda mellan de olika däcken. Vinterdäcken, dubbade likväl som dubbfria, hade lika bra grepp på asfalt som det testade sommardäcket. När det gäller isgrepp så var det de två däcken med flest dubbar, 240 stycken, som var klart bättre än de övriga.

    Rullmotståndtesterna visade på skillnader mellan de olika däcken och det är inte mängden dubbar utan snarare gummiblandning och punkteringsskydd som har störst påverkan på rullmotståndet. Slitagetesterna indikerade att några av de testade modellerna kan vara särskilt benägna att tappa dubbar, men då testerna endast inkluderade två exemplar av varje däckmodell så går det inte att dra säkra slutsatser angående slittålighet.

  • Grönwall, Anders
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio philosophica, de praxi morali nexusque rerum in ea scrutinio, quam ... præside ... Andrea Grönwall ... pro gradu, publico examini modeste submittet ... Nicolaus Dahlerus, Calmariensis, in audit: Carol. majori, die XVI. maji, a:o MDCCXLVI.1746No name for locale no (Annet vitenskapelig)
  • Grönwall, Anders
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio politica, de obsequio legibus humanis præstando, quam ... sub præsidio ... Andreæ Grönwall ... publico examini modeste submittit Andreas Utterström, Westmannus. In auditorio Carolino majori, ad diem VIII. junii, MDCCXLIV.1744No name for locale no (Annet vitenskapelig)
  • Grönwall, Anders
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Exercitium academicum, de fundamento juris proëdriæ inter gentes, quod ... sub præsidio ... Andreæ Grönwall ... bonorum examini modeste subjicit, alumnus regius Carolus Beckstadius, Calmariensis. In audit. Gustav. majori ad d. 2[4?] decemb. anni MDCCXLIII.1743No name for locale no (Annet vitenskapelig)
  • Grönwall, Anders
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio gradualis, de Christianismo, veræ politicæ, non adverso. Quam ... sub præsidio ... Andreæ Grönwall ... publicæ ventilationi sistit, alumnus regius, Gustavus Fellenius, Westmannus. In audit. Carol. maj. ad diem XVII. junii, anni MDCCXLIII.1743No name for locale no (Annet vitenskapelig)
  • Grönwall, Anders
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio philosophica, de necessitate et præstantia virtutum intellectualium, quam ... præside ... Andrea Grönwall ... pro gradu, publico bonorum examini modeste submittit, alumnus regius, Laurentius Magnus Wimmerstedt, Calmariensis. In audit. Gustav. major, ad diem [15] junii, anni MDCCXLIII.1743No name for locale no (Annet vitenskapelig)
  • Grönwall, Anders
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio historico-moralis, controversiam, inter archi-episcopum & ducem Cameracensem, Fenelonium, ac episcopum Meldemsem, Bossuetum, de fundamento amoris erga Deum, sistens; quam ... præside ... Andrea Grönwall ... pro gradu, publico examini modeste submittit, Andreas Wetterblad, Ostrobotniensis. In auditorio Gustaviano maj. ad diem 25. April. anni MDCCXLIII.1743No name for locale no (Annet vitenskapelig)
  • Grönwall, Anders
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio philosophica, de regimine affectuum, cujus partem posteriorem ... præside ... Andrea Grönwall ... pro gradu, ad publicum examen, ea, qua par est, modestia defert, stipendiarius Sparrfeldianus, Carolus Wimmerstedt, Calmariensis. In auditorio Gust. majori ad diem [ ] junii, anni MDCCXLIII., P. 21743No name for locale no (Annet vitenskapelig)
  • Grönwall, Anders
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio philosophica, de regimine affectuum, cujus partem priorem ... præside ... Andrea Grönwall ... ad publicum examen, ea, qua par est, modestia defert, stipendiarius Sparrfeldianus, Carolus Wimmerstedt, Calmariensis. In auditor. Gustav. majori, ad d. 30 martii, anni MDCCXLIII., P. 11743No name for locale no (Annet vitenskapelig)