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  • Benzelstierna, Lars
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology.
    Dissertatio theologica, munera ministerii ecclesiastici foeminis abjudicata evincens, quam, consent. max. venerand. fac. theol. in reg. acad. Upsal. præside ... Laurentio Benzelstierna ... publico examini offert, stipendiarius Zedritzianus, Johannes Wenström, Uplandus. In audit. Carol. maj. die [XVI] Nov. MDCCLI. h. a. m. s.1751Dissertation (older thesis) (Other academic)
  • Benzelstierna, Lars
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology.
    Specimine academico discrimen inter confessionem Augustanam invariatam et variatam, consentiente ... facult. theolog. in reg. acad. Upsaliensi, præside ... Laurentio Benzelstierna ... publice ventilandam sistit Nicolaus Ascher, Vermelandus, in aud. Carol. maj. die [I.] Julii. anni MDCCLI. H. A. M. S.1751Dissertation (older thesis) (Other academic)
  • Benzelstierna, Lars
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology.
    Specimine academico necessitatem reformationis Lutheranæ, ex consensu ven. facult. theol. in reg. acad. Ups. præside ... Laurentio Benzelstierna ... publice examinandam sistit Petrus Arrhenius Larsson, Uplandus, in audit. Carol. maj. die [III Octobr.] anni MDCCL.1750Dissertation (older thesis) (Other academic)
  • Benzelstierna, Lars
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology.
    Exercitium academicum, de symbolo Athanasiano, ex consensu ven. facult. theol. in regia academia Upsaliensi, præside ... Laur. Benzelstierna ... publico examini modeste submittit, Johannes Hamberg, v. d. m. Medelpadus, in audit. Carol. maj. die VI. Junii, anni MDCCXLIX, horis, ante meridiem, solitis.1749Dissertation (older thesis) (Other academic)
  • Benzelstierna, Lars
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Diatriba philologica, de pentathlou, seu certaminum gymnicorum apud Græcos, origine, cum adplicatione ad res patrias, cujus partem primam, indulg. ampliss. Facult. Philos. in illustri athenæo Upsalensi, præside, ... Laur. Benzelstierna, ... publico examini modeste subjicit ... Christianus Rosbeck, Uplandus. in audit. Carol. maj. die V. Nov. MDCCXLVIII1748Dissertation (older thesis) (Other academic)
  • Benzelstierna, Lars
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology.
    Dissertatio historico-theologica, de symbolo apostolico, quam, consent. vener. facult. theol. in regia academia Upsaliensi, præside ... Laurentio Benzelstierna ... publico examini modeste subjicit Petrus Wastenius, Cuprimontano-Dalekarlus. In audit. Carol. maj. ad d. XXX Junii. anni MDCCXLVIII. H. a. m. s.1748Dissertation (older thesis) (Other academic)
  • Benzelstierna, Lars
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology.
    Schediasma de Juliano imperatore vere apostata contra Arnoldum et observatores Halenses quod, consentiente vener. facult. theol. in incluta academia Upsaliensi, præside ... Laur. Benzelstierna ... stipendiarius Helmfeldianus, Ulricus D. Voltemat, in audit. Carol major. d. XVIII. Maji. anni MDCCXLVIII.1748Dissertation (older thesis) (Other academic)
  • Bucht, Gösta
    Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
    Clinical and etiological studies on dementia of Alzheimer type and multiinfarct dementia1983Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    1. Clinical studies. Clinical diagnosis of dementia has been made largely on the basis of clinical findings supported by appropriate radiological and laboratory investigations. A minority of patients have treatable or reversible underlying causes for their dementing syndrome. It is important to distinguish between the two main forms of dementia Alzheimer's disease, senile dementia of Alzheimer type (AD/SDAT) and MID so that advantage can be taken of any future progress in treatments.

    In the clinical study significant differences between several diagnostic procedures were found between patients with AD/SDAT and MID. Blood pressure was significantly lower in the AD/SDAT group and focal neurological signs were seen in 70% of the MID patients but only in 6% of patients with AD/SDAT. Electrocardiogram was normal in all patients with AD/SDAT but pathological in 75% of the MID patients. Electroencephalogram showed generalized slow frequencies in 79% of the AD/SDAT patients and localized changes in 65% of the MID patients. Computerized tomography showed a significantly greater dilation of the ventricular system in MID patients compared to AD/SDAT patients and controls. Monoamine metabolites in the cerebrospinal fluid were lower in AD/SDAT patients and normal in MID patients. Psychopathological signs were found to be more variable and more pronounced in the AD/SDAT group compared with MID patients.

    2. Etiological studies. Immunoglobulin and albumin were found changed in serum and CSF of both AD/SDAT and MID, indicating a more active immune response in MID and a less dense cerebrospinal fluid barrier in both MID and AD/SDAT. There appears to be a consumption of IgG in the central nervous system in patients with AD/SDAT.

    Abnormal chromosomes appearing as acentric fragments, i.e. without visible centromeres, were found in 90% of patients with AD/SDAT, 30% of patients with MID, and not at all in the control group. Increased aneuploidy was also seen both in patients with MID and AD/SDAT.

    Diabetes mellitus in old age and AD/SDAT do not seem to ’ coexist. Furthermore, patients with AD/SDAT have changed carbohydrate metabolism with decreased fasting blood sugar concentrations, increased glucose tolerance and higher concentration of insulin during an oral glucose tolerance test.

  • Public defence: 2017-11-10 09:15 B41, Uppsala
    Åkerbladh, Linda
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Palladium(0)-Catalysed Carbonylative Multicomponent Reactions: Synthesis of Heterocycles and the Application of Quinolinyl Pyrimidines as Enzyme Inhibitors2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Palladium-catalysed carbonylative multicomponent reactions have proven useful for the synthesis of structurally diverse compounds. Carbon monoxide serves as an atom-efficient, one-carbon building block, which allows for further structural elaboration of the carbonyl compound. By varying the components of the carbonylative multicomponent reaction, considerable product diversity can readily be attained. However, due to the reluctance to use toxic CO gas, considerable efforts have been directed at exploring non-gaseous approaches. The work described in this thesis has mainly focused on the development of palladium(0)-catalysed, carbonylative multicomponent synthetic methodology, using the non-gaseous CO source molybdenum hexacarbonyl, in the synthesis of heterocycles and other biologically relevant functional groups.

    The first part of this work describes the development of a non-gaseous carbonylative Sonogashira cross-coupling of bifunctional ortho-iodoanilines and terminal alkynes. Where 4-quinolones were synthesised via a carbonylation/cyclisation sequence. Using a similar synthetic strategy, three different N-cyanobenzamide intermediates were prepared by palladium-catalysed carbonylative couplings of various aryl halides and bromides and cyanamide. The formed intermediates provided a basis for further chemical transformations. First, ortho-iodoanilines were carbonylatively coupled with cyanamide and subsequently cyclised to yield heterocyclic 2-aminoquinazolinones. Next, building on those findings, the same synthetic strategy was applied to ortho-halophenols to provide a highly convenient domino carbonylation/cyclisation method for the preparation of benzoxazinones. The developed method was used to evaluate the efficiency of various non-gaseous CO sources. Third, the palladium-catalysed carbonylative synthesis of N-cyanobenzamides, was used to produce biologically relevant N-acylguanidines with considerable product diversity. Finally, one of the developed carbonylative methodologies was used in the preparation of potential NDH-2 inhibitors based on a quinolinyl pyrimidine scaffold. The prepared compounds were biologically evaluated in terms of inhibition of oxidoreductase NDH-2 and antibacterial activity on Gram-negative bacteria, S. aureus and Mtb. The biological evaluation revealed that some of the quinolinyl pyrimidines exerted inhibitory activity on the NDH-2 enzyme and possessed antibacterial properties.

    The work described in this thesis has been devoted to the development of non-gaseous one-pot, multicomponent carbonylation/cyclisation and carbonylation/amination reactions. The described methods offer highly attractive synthetic strategies that can be of great value to synthetic and medicinal chemists.

  • Abelsson, Anna
    Karlstads universitet, Institutionen för hälsovetenskaper.
    Simulering som lärande inom prehospital akutsjukvård2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The overall aim of the research was to deepen the understanding of learning through simulation in prehospital emergency care.

    Method: In this research, qualitative and quantitative methods are used as well as integrative literature studies (I, II). Qualitative data from the interview studies (III, V) were analyzed by phenomenographic methodology. Quantitative data from the intervention study (IV) were analyzed using descriptive and analytical statistics.

    Results: Research on simulation and learning within the prehospital trauma care context is relatively rare (I). Simulation of realistic scenarios where the caregivers are exposed to stress contributes to strengthen caregiver knowledge, skills and experience (II). Caregivers request simulation opportunities regarding critical and emergency situations (III). They describe that learning through regular simulation provides in-depth knowledge and skills in the care of a patient exposed to high-energy trauma (V). Interventions with repeated simulation opportunities related to the care of the patient exposed to high-energy trauma give some improvement in care provided at the site of the accident (IV).

    Conclusion: Through simulation, the caregivers develop knowledge and skills and receive enhanced confidence in the care of an injured and sick patient. The research suggests several areas with potential for improvement with regard to the care of patients exposed to high-energy trauma. A model has been developed for systematic trauma simulation.


  • Berg, Jessica
    et al.
    Swedish National Road and Transport Research Institute, Society, environment and transport, Mobility, actors and planning processes.
    Ihlström, Jonas
    Swedish National Road and Transport Research Institute, Traffic and road users, Trafikanttillstånd, TIL.
    Kollektivtrafikens betydelse för mobilitet och vardagsaktiviteter hos hushåll på landsbygd: intervjustudie2017Report (Other academic)
    Abstract [en]

    On behalf of the government, VTI has the commission to implement a study on effective and innovative solutions that can enhance people’s willingness and ability to use public transport in rural areas in Sweden. This interview study is part of the commission and aims to highlight local examples of how access to transport meet the needs for mobility and participation in everyday activities among residents in rural areas. The following questions should be answered:

    1) What positive and negative aspects of living in rural areas are described?

    2) How are different modes of transport used?

    3) To what extent can public transport meet their mobility needs?

    The empirical material consists of interviews with people from 14 households living in rural areas that are close to urban neighborhoods. The rural areas are in the municipality of Kinda in Östergötland, Falun in Dalarna and Östersund in Jämtland. The results present positive and negative aspects of living in rural areas, the use of different transport modes, perceived restrictions and benefits of using public transport, the importance of the car and the informants' suggestions for solutions that could increase the use of public transport. Measures and improvements that can increase the ability to travel by public transport and reduce car trips are: public transport that connects rural areas with public transport hubs to increase access to high-demand routes; coordination between publicly funded school transport and public transport; access to shops and services at hubs; coordination between counties to offer efficient public transport to main urban centers, considering geographical proximity rather than administrative borders; and, integration of a wide variety of different mobility tools such as car-pooling, ride-sharing, public and demand-responsive public transport as well as bike rental services.

  • Freij, Lennart
    et al.
    Wall, Stig
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Nyström, Lennarth
    Exploring child health and its ecology: the Kirkos study in Addis Ababa. An evaluation of community utilization of a mother and child health clinic1977Doctoral thesis, monograph (Other academic)
  • Samuelson, Gösta
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
    An epidemiological study of child health and nutrition in a northern Swedish county1971Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis is a summary of the following original papers:

    I. An epidemiological study of child health and nutrition in a northern Swedish county. I. Food consumption survey. Acta Paediat Scand, 60: Suppl. 214, 1971.

    II. An epidemiological study of child health and nutrition in a northern Swedish county. II. Methodological study of the recall technique. Nutr Metabol, 12: 321, 1970.

    III. An epidemiological study of child health and nutrition in a northern Swedish county. III. Medical and anthropometrical examinations. Acta Paediat Scand, 60, 1971. In press.

    IV. An epidemiological study of child health and nutrition in a northern Swedish county. IV. Haematological investigations, especially in regard to iron deficiency anaemia. Acta Paediat Scand, 60, 1971. In press. In collaboration with S. Sjölin.

    V. An epidemiological study of child health and nutrition in a northern Swedish county. V. Oral health studies. Odont. Rev, 22, 1971. In press. In collaboration with H. Grahnén and G. Lindström.

    VI. An epidemiological study of child health and nutrition in a northern Swedish county. VI. Relationship between general and oral health, food habits and socio-economic conditions. In collaboration with H. Grahnén and E. Arvidsson. To be published, 1971.

  • Maaroufi, Nadia I.
    et al.
    Nordin, Annika
    Palmqvist, Kristin
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Gundale, Michael J.
    Nitrogen enrichment impacts on boreal litter decomposition are driven by changes in soil microbiota rather than litter quality2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 4083Article in journal (Refereed)
    Abstract [en]

    In nitrogen (N) limited boreal forests, N enrichment can impact litter decomposition by affecting litter quality and by changing the soil environment where litter decomposes. We investigated the importance of litter quality and soil factors on litter decomposition using a 2-year reciprocal transplant experiment for Picea abies needle litter, derived from plots subjected to 17 years of N addition, including control, low and high N treatments (ambient, 12.5 and 50 kg N ha(-1) yr(-1), respectively). Our data show that changes in soil factors were the main pathway through which N impacted litter decomposition, with rates reduced by approximate to 15% when placed in high N relative to control plots, regardless of litter origin. Litter decomposition was correlated to soil microbiota, with Picea abies litter decomposition positively correlated with gram negative and fungal functional groups. Our results suggest that previous findings of increase soil C accumulation in response to N deposition is likely to occur as a result of changes in soil microbiota rather than altered litter quality.

  • Roos, Anna
    Executive, Naturhistoriska riksmuseet, NRM.
    Fiskgjuse - Miljögiftsbelastning i ägg insamlade i Sverige2013Report (Other academic)
    Abstract [sv]

    Inom ramen för Projekt fiskgjuse har ägg från Sverige, framför allt södra Sverige, analyserats med avseende på klorerade, bromerade och fluorerade ämnen samt tungmetaller, metylkvicksilver och selen. Dessutom har äldre analysdata avseende kvicksilver datalags och inkorporerats i denna rapport.


    Sju ägg som tidigare analyserats för Hg analyserades på nytt för att se om analysresultaten är jämförbara, vilket de var. Därmed kunde gamla och nya resultat avseende kvicksilver läggas ihop i en trendanalys. Halterna av kvicksilver i de analyserade äggen (n=211) har minskat med ca 2,1% årligen sedan 1960-talet. Halter överstigande 500 ng/g våtvikt (v.v.) i ägg kan förknippas med negativa effekter på reproduktionen hos vissa rovfåglar. Elva procent av äggen år 1964-1986 hade halter överskridande 500 ng/g v.v., men inget av de 20 ägg som analyserats från 2008-2013 överskred detta värde.

    Halterna av selen vs kvicksilver (n=29) på molviktsbasis visar på ett överskott av selen. En jämförelse mellan metylkvicksilver och totalkvicksilver visade att så gott som allt kvicksilver i äggen är av formen metylkvicksilver. Även halterna av koppar, zink och mangan har minskat i de analyserade äggen (mellan 0,9-2,2% årligen, n=29). Selen visade på en tendens till minskning, dock inte statistiskt signifikant.

    Samtliga analyserade pesticider har också minskat över tid, med ca 6-10% årligen (HCB, transnonaklordan, transklordan, cis-klordan, p,p´-DDE, p,p´-DDE och p,p´-DDD, n=60). Även 22 analyserade CB-kongener minskade i halt över tid, med mellan 3-8% årligen (n=60).

    De sex BDEs som fanns i mätbara halter i samtliga ägg (BDE-28, -47, -99, -100, -153, och -154) ökade i halt fram till 2001 och därefter sågs en minskning för tre av dem (BDE-47, -99 och -100). BDE-28, -153 och -154 har inte minskat i halt sedan 2001 (n=60). Trots en minskning av tre kongener sedan 2001 så är medelhalten ΣBDE i äggen från 2013 högre än de från början av tidsserien (1960-talet).

    Trettio ägg från 1997-2013 har analyserats för 16 perfluorerade/högfluorerade ämnen (PFAS) inom projektet: de perfluorerade karboxylsyrorna (PFCA) PFBA, PFPePA, PFHxA, PFHpA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, PFTrDA, PFTeDA, PFHxDA och PFOcDA samt de perfluorerade sulfonsyrorna (PFSA) PFHxS, PFOS och PFDS Nio föregångarämnen (s.k. prekursorer) analyserats, 5:3 FTCA, 6:2 FTUCA, 7:3 FTCA, 8:2 FTUCA, 10:2 FTUCA, N-MeFOSA, N-EtFOSA, N-MeFOSE och N-EtFOSE. Nästan alla ägg hade halter under detektionsgränsen avseende de kortkedjiga karboxylaterna PFBA, PFPePA, PFHxA, PFHpA, samt PFOA liksom samtliga prekursorer förutom 7:3 FTCA. PFOS var det mest dominerande ämnet, andelen PFOS vs PFAS var i snitt 72% (43-95%). Halterna PFOS låg mellan 12-632 ng/g v.v. Det finns rapport om att 100 ng PFOS/g ägg är den lägsta halt (LOEL) som ger negativ påverkan på häckningsresultatet hos höns. I denna studie hade 40% av fiskgjuseäggen från 2013 halter över 100 ng/g v.v. och fortsatt övervakning av dessa ämnen är önskvärt.

    Halterna av ΣPFCA visade på en tendens till ökning, dock inte statistiskt signifikant (p<0,08) medan ΣPFSA låg stabilt över tidsperioden 1997-2013 och fortsatt övervakning av dessa ämnen är önskvärt liksom PBDEs mf

  • Janunger, Karl-Gunnar
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
    Benign and malignant gastric mucosal changes after partial gastrectomy1978Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    anunger, Karl-Gunnar. Benign and malignant gastric mucosal changes after partial gastrectomy.

    The development of benign and malignant mucosal changes in the gastric remnant were studied early (1-3 years) postoperatively in 55 patients and late (10-24 years) postoperatively in 336 of 676 patients subjected to partial gastrectomy for ulcer disease.

    Chronic gastritis with atrophy, intestinal metaplasia and cystic dilatation of the gastric glands was found early postoperatively with the same prevalence in gastric and duodenal ulcer patients. Wiereas the prevalence of atrophy, and of acute and chronic gastritis was the same both early and late postoperatively, the prevalence of intestinal metaplasia, cystic dilatation and lipid islands increased with time. The prevalence of inflammatory changes late postoperatively was not correlated to sex, age or type of anastomotic procedure.

    A significantly increased risk for stump carcinoma was found in male patients more than 12 years postoperatively. No difference correlated to type of ulcer disease or anastomotic procedure could be demonstrated. In duodenal ulcer patients the time interval between operation and diagnosis of carcinoma was independent of age at operation, while in gastric ulcer patients the interval was shorter with increasing age at operation.

    Gastric stump carcinomas were found in 12 of the 336 (3.6?£) patients examined gastroscopically; four of these were early carcinomas. In four patients with stump carcinoma the correct diagnosis could not be established at the first examination.

    Gastric polyps and precancerous mucosal changes were the only macro- or microscopical findings in some cases with already existing non-visible carcinoma.

    The CEA immunohistochemical study of the gastric mucosa showed a positive reaction in 10 of 49 patients; 6 of the 10 had carcinoma, precancerous changes or adenomatous polyp. Three patients with diagnosed or later discovered carcinoma had CEA negative reactions. However, the results indicate that there is a correlation between demonstrated CEA content and increased risk for development of stump carcinoma. To evaluate whether this method can be used to identify patients at special risk for development of gastric carcinoma requires further study.

    Because of increased risk for stump carcinoma, gastric ulcer patients ought to be examined with gastroscopy from about 10 years after partial gastrectomy, and duodenal ulcer patients from about 15 years, irrespective of the type of anastomotic procedure. Rç-examinations ought to be performed every two to four years. In patients with gastric polyps or precancerous mucosal changes re-examinations should be performed earlier, within 6-12 months.

  • Christianson, Sven-Åke
    Umeå University, Faculty of Social Sciences, Department of Psychology.
    Amnesia and emotional arousal1984Doctoral thesis, monograph (Other academic)
    Abstract [en]

    The purpose of the present thesis was twofold. First, to study the role of emotional arousal in memory processes, and secondly, to relate this concept to empirical findings of amnesia. In both clinical and experimental settings it has been observed that remembering is impaired for events occurring prior to, and after a traumatic critical event. This memory impairment is also demonstrated for the traumatic event per se. In relation to these phenomena an interaction is commonly observed such that remembering of events aquired in a state of high emotionality, or arousal, is inferior to events aquired in neutral low arousal conditions at short test intervals, but superior at delayed test intervals. The general notion to be tested was how and to what extent these phenomena are mediated by an increase in emotional arousal. In order to test this hypothesis a series of experiments was designed so that retrograde and anterograde amnesia, and amnesia for the traumatic event, could be studied so as to evaluate the locus of the emotional arousal and amnesia effects with respect to encoding (attention), storage (consolidation), and retrieval (reconstruction). Emotional arousal was induced by sources associated with the to-be-remembered (TBR) material (traumatic pictures), and by sources not associated with the TBR-material (injections of adrenalin). Memory performance was measured by recall and recognition techniques. Amnesia was obtained only when the source of arousal was associated with the TBR-items. It was concluded that amnesia in connection to hightened emotional arousal depends on attention demanding characteristics of the traumatic event, rather than physiological properties of hightened arousal per se. An interaction between factors at encoding and retrieval was proposed as an explanation for the amnesia effects obtained. An interpretation in terms of consolidation has, throughout this thesis, been shown to be invalid in explaining the memory phenomena referred to.

  • Holmlund, Dan
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences. Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology. Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Ureteral stones: an experimental and clinical study of the mechanism of the passage and arrest of ureteral stones1968Doctoral thesis, monograph (Other academic)
  • Public defence: 2017-11-15 13:00 Visualization Studio VIC, Stockholm
    Saikia, Himangshu
    KTH, School of Computer Science and Communication (CSC), Computational Science and Technology (CST).
    Comparison and Tracking Methods for Interactive Visualization of Topological Structures in Scalar Fields2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Scalar fields occur quite commonly in several application areas in both static and time-dependent forms. Hence a proper visualization of scalar fieldsneeds to be equipped with tools to extract and focus on important features of the data. Similarity detection and pattern search techniques in scalar fields present a useful way of visualizing important features in the data. This is done by isolating these features and visualizing them independently or show all similar patterns that arise from a given search pattern. Topological features are ideal for this purpose of isolating meaningful patterns in the data set and creating intuitive feature descriptors. The Merge Tree is one such topological feature which has characteristics ideally suited for this purpose. Subtrees of merge trees segment the data into hierarchical regions which are topologically defined. This kind of feature-based segmentation is more intelligent than pure data based segmentations involving windows or bounding volumes. In this thesis, we explore several different techniques using subtrees of merge trees as features in scalar field data. Firstly, we begin with a discussion on static scalar fields and devise techniques to compare features - topologically segmented regions given by the subtrees of the merge tree - against each other. Second, we delve into time-dependent scalar fields and extend the idea of feature comparison to spatio-temporal features. In this process, we also come up with a novel approach to track features in time-dependent data considering the entire global network of likely feature associations between consecutive time steps.The highlight of this thesis is the interactivity that is enabled using these feature-based techniques by the real-time computation speed of our algorithms. Our techniques are implemented in an open-source visualization framework Inviwo and are published in several peer-reviewed conferences and journals.

  • Public defence: 2017-11-14 10:00 sal 14, hus 5, Kräftriket, Stockholm
    Neuner, Christoph
    Stockholm University, Faculty of Science, Department of Mathematics.
    On Supersingular Perturbations2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis consists of four papers and deals with supersingular rank one perturbations of self-adjoint operators and their models in Hilbert or Pontryagin spaces. Here, the term supersingular describes perturbation elements that are outside the underlying space but still obey a certain regularity conditions.

    The first two papers study certain Sturm-Liouville differential expressions that can be realised as Schrödinger operators. In Paper I we show that for the potential consisting of the inverse square plus a comparatively well-behaved term we can employ an existing model due to Kurasov to describe these operators in a Hilbert space. In particular, this approach is in good agreement with ODE techniques.

    In Paper II we study the inverse fourth power potential.While it is known that the ODE techniques still work, we show that the above model fails and thus that there are limits to the above operator theoretic approach.

    In Paper III we concentrate on generalising Kurasov's model. The original formulation assumes that the self-adjoint operator is semi-bounded, whereas we drop this requirement. We give two models with a Hilbert and Pontryagin space structure, respectively, and study the connections between the resulting constructions.

    Finally, in Paper IV, we consider the concrete case of the operator of multiplication by the independent variable, a self-adjoint operator whose spectrum covers the real line, and study its perturbations. This illustrates some of the formalism that was developed in the previous paper, and a number of more explicit results are obtained, especially regarding the spectra of the appearing perturbed operators.

  • Public defence: 2017-11-14 10:00 William-Olssonsalen, Geovetenskapens hus, Stockholm
    Uzdavinys, Povilas
    Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
    Establishing the molecular mechanism of sodium/proton exchangers2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Sodium/proton exchangers are ubiquitous secondary active transporters that can be found in all kingdoms of life. These proteins facilitate the transport of protons in exchange for sodium ions to help regulate internal pH, sodium levels, and cell volume. Na+/H+ exchangers belong to the SLC9 family and are involved in many physiological processes including cell proliferation, cell migration and vesicle trafficking. Dysfunction of these proteins has been linked to physiological disorders, such as hypertension, heart failure, epilepsy and diabetes.

    The goal of my thesis is to establish the molecular basis of ion exchange in Na+/H+ exchangers. By establishing how they bind and catalyse the movement of ions across the membrane, we hope we can better understand their role in human physiology.

    In my thesis, I will first present an overview of Na+/H+ exchangers and their molecular mechanism of ion translocation as was currently understood by structural and functional studies when I started my PhD studies. I will outline our important contributions to this field, which were to (i) obtain the first atomic structures of the same Na+/H+ exchanger (NapA) in two major alternating conformations, (ii) show how a transmembrane embedded lysine residue is essential for carrying out electrogenic transport, and (iii) isolate and recorde the first kinetic data of a mammalian Na+/H+ exchanger (NHA2) in an isolated liposome reconstitution system.

  • Public defence: 2017-11-10 09:00 Sal A, byggnad 23, Umeå
    Löfgren, Hans O.
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Child and Adolescent Psychiatry.
    Preventive psychosocial parental and school programmes in a general population2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Introduction Numerous preventive programmes have emerged, and need to be investigated to determine their effects on the normal population. Earlier studies have shown a decrease in depressive symptoms, positive effects on children’s disruptive behaviour problems, and an improvement in parental competence. About a fifth of the parents in previous studies had problem-oriented (targeted) reasons for enrolment, whereas the rest of the parents had general (universal) reasons. The results of those studies suggest that the programmes are cost effective in terms of Quality-Adjusted Life Years.

    Aim Four sub-studies were performed, and their aims were to investigate the effect of parental training programmes (PTPs) in a naturalistic setting on parents’ mental health in the general population, to investigate how PTPs affect parents’ sense of parental competence, to investigate how PTPs affect parental stress and analyse the parents open questions about the PTPs, and to investigate the feasibility and to measure the effect on depression, anxiety, and social problems of two preventive school programmes for pupils in grade 7.

    Method In a longitudinal quantitative study in a real-world setting, 279 parents from the general population in northern Sweden participated in five PTPs. A comparison group of 702 parents without intervention was included. Simultaneously, a community sample of 59 pupils in grade 7 participated in two preventive school programmes. Both studies were conducted from 2010 to 2013. Parents were assigned to professionally supported interventions that included 5-10 two-hour sessions. Respondents filled in a web-based questionnaire with the General Health Questionnaire (GHQ), the Parents Sense of Competence (PSOC) for parents who had children aged 0-17 years, and the Swedish Parenthood Stress Questionnaire (SPSQ) for parents who had children aged 0-10 years. The intervention groups’ results were compared to comparison group of 702 parents from northern Sweden that had not participated in any parental training programme. In the school study, one of the preventive programmes was an ongoing programme called “Life-Skills”, and the other was an implemented Canadian programme called “Choosing Healthy Actions and Thoughts” (CHAT). The pupils completed a test battery including the Sense of Coherence (SOC), the Children’s Depression Inventory (CDI), and the Youth Self-Report (YSR) instruments. Follow up of the parental programme study was done six months after the post-intervention measure, and follow up of the school study was at one year.

    Results The improvements in GHQ were statistically significant for the mean of the 279 parents in the intervention group compared to the mean of a comparison group of the 702 parents who did not receive any intervention. This suggests that evidence-based PTPs enhance parental well-being even for parents without problems. The intervention group showed a statistically significant improvement in parental competence compared to the comparison group over time. The intervention itself had a significant effect on parental satisfaction, but the efficacy effect was not sustained when taking into account potential confounders. In the SPSQ, the intervention group was smaller due to the fact that the instrument was not validated for children over the age of 10 and one of the parental training groups was only for parents of teenagers. A reduction of stress in the sub-scale of health problems was detected, but no other subscale showed the intervention to have a significant effect when controlling for confounding variables. In the school study, both programmes had good feasibility according to the stake- holders and had several positive mental health outcomes over time. Compared to Life-Skills, CHAT had more significant positive effects on reducing anxious/depressive symptoms and girls experienced significant positive effects on reduced anxious/depressive behaviour, while boys reduced their aggressive behaviours.

    Conclusions Earlier studies indicate that PTPs enhance perceived parental competence among referred parents. The present study shows that PTPs applied in the general population might also enhance perceived parental benefits such as improved health and satisfaction, suggesting that PTPs can be an important preventive strategy to enhance parenthood. The results suggest that parents who feel a need to increase their parenting competence might participate in PTPs based on lower scores than the comparison control group both before and after the intervention. The school-based programme shows that schools may be a suitable arena for preventive programmes because there was a significant short-term improvement in depression symptoms. Further studies need to explore how parents’ participation in PTPs affects children’s mental health in the general population in quantitative longitudinal studies in real-word settings. There is also a need for bigger studies and RCTs on school preventions and on how children’s health develops naturally in the population.

  • Wennerhag, Magnus
    Södertörn University, School of Social Sciences, Sociology.
    Sociala rörelser, protester och politiskt våld – en forskningsöversikt2017In: Våldsbejakande extremism: en forskarantologi / [ed] Christofer Edling och Amir Rostami, Stockholm: Wolters Kluwer, 2017, 291-322 p.Chapter in book (Other academic)
    Abstract [sv]

    Den samtida forskningen om sociala rörelser erbjuder en rad insikter om politiskt motiverat våld: varför det uppkommer, vad som gör att våldsanvändning kan eskalera, men även vad som bidrar till att grupper inom en rörelse undviker eller slutar att använda våld. När man inom forskningen om sociala rörelser talar om radikalisering avser man vanligen de processer som leder till att grupper av aktivister inom en rörelse börjar använda våld eller trappar upp sitt användande av våld.

    Inom andra forskningsfält brukar radikalisering ofta relateras till sociala bakgrundsfaktorer, individuella omständigheter eller personlighetsdrag, vilka antas bidra till att enskilda individer börjar använda politiskt motiverat våld eller ansluter sig till grupper där våld används. En sådan förståelse av radikalisering har inte sällan legat till grund för myndighetsåtgärder för att förebygga eller bekämpa politiskt motiverad våldsbrottslighet.

    Utgångspunkten inom forskningen om sociala rörelser är i stället att de flesta individer som utför politiskt motiverade våldshandlingar redan är en del av en social rörelse. Det blir därmed relevant att undersöka de sociala processer inom en rörelse som kan leda till att vissa grupper inom en rörelse använder våld, samt hur dessa processer påverkas av interaktion med aktörer utanför rörelsen. Detta innebär också att forskningen inom detta fält mer sällan intresserar sig för de enskilda utövare av politiskt våld som agerar på egen hand och inte är knutna till en rörelse.

    Samtidigt har forskningen om sociala rörelser länge undersökt vilka individer som ansluter sig till rörelser och varför de gör det. I vissa studier har det även undersökts vilka individuella omständigheter som påverkar att rörelseaktivister börjar använda olagliga eller våldsamma metoder. Därmed kan den empiriska forskningen inom detta fält kasta nytt ljus över den förståelse av radikalisering som dominerat annan forskning och myndighetsåtgärder.

    I detta kapitel ges inledningsvis en övergripande bild av forskningsfältets framväxt och huvudsakliga kunskapsintressen. Därefter introduceras hur man inom detta fält har betraktat och undersökt fenomenet politiskt våld. Detta följs av en översikt över de faktorer som forskningen kunnat visa är betydelsefulla för att individer ansluter sig till sociala rörelser, samt för att vissa rörelseaktivister börjar använda våldsamma metoder. Därefter diskuteras forskningen om radikaliseringsprocesser, vilket här förstås som när grupper inom en social rörelse börjar använda politiskt motiverat våld. I fokus står de mekanismer på gruppnivå som vanligen är centrala för att grupper inom en social rörelse radikaliseras, något som även möjliggör insikter om hur dessa processer kan avbrytas. 

  • Gren, Erik
    Uppsala University, University Library.
    Orientalia Suecana: Volume 31954Collection (editor) (Refereed)
  • Overkamp, Timothy
    et al.
    Linköping University, Department of Computer and Information Science, Human-Centered systems. Linköping University, Faculty of Science & Engineering.
    Holmlid, Stefan
    Linköping University, Department of Computer and Information Science, Human-Centered systems. Linköping University, Faculty of Science & Engineering.
    Marionette prototyping for evaluating conceptual ubicomp applications in their context2015In: PIN-C 2015. Reframing Design. Proceedings of the 4th participatory innovation conference: reframing design / [ed] Rianne Valkenburg, Coen Dekkers and Janneke Sluijs, The Hague University of Applied Science /Syddansk Univeristet , 2015, 462-469 p.Conference paper (Refereed)
    Abstract [en]

    There are many methods for the evaluation of ubiquitous computing (ubicomp) applications. These evaluations usually require an autonomous system, or use scenarios or storyboards instead.

    We suggest Marionette Prototyping as a technique for ubicomp applications that can be used early in the design process. It allows participants to use a conceptual ubicomp application in a real-world context, followed by an evaluation that covers the participants understanding, experience and attitude with regard to the application. Marionette Prototyping is inspired by puppetry, especially the styles where the manipulator is in plain view. It combines principles from cardboard prototyping and Wizard-of-Oz and uses off-the-shelf tools and technology.

    We have used Marionette Prototyping in the evaluation of a ubicomp application. This evaluation has shown that Marionette Prototyping provides input on the understanding, experience and attitude of the user with regard to the ubicomp application in question. From this first step, we can continue to develop this method as a technique for early, in context evaluation of ubicomp applications. In this, Marionette Prototyping can overcome some of the issues with current evaluation methods for ubicomp applications 

  • Davoine, Celine
    et al.
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Abreu, Ilka N.
    Khajeh, Khalil
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Blomberg, Jeanette
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Kidd, Brendan N.
    Kazan, Kemal
    Schenk, Peer M.
    Gerber, Lorenz
    Nilsson, Ove
    Moritz, Thomas
    Björklund, Stefan
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Functional metabolomics as a tool to analyze Mediator function and structure in plants2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 6, e0179640Article in journal (Refereed)
    Abstract [en]

    Mediator is a multiprotein transcriptional co-regulator complex composed of four modules; Head, Middle, Tail, and Kinase. It conveys signals from promoter-bound transcriptional regulators to RNA polymerase II and thus plays an essential role in eukaryotic gene regulation. We describe subunit localization and activities of Mediator in Arabidopsis through metabolome and transcriptome analyses from a set of Mediator mutants. Functional metabolomic analysis based on the metabolite profiles of Mediator mutants using multivariate statistical analysis and heat-map visualization shows that different subunit mutants display distinct metabolite profiles, which cluster according to the reported localization of the corresponding subunits in yeast. Based on these results, we suggest localization of previously unassigned plant Mediator subunits to specific modules. We also describe novel roles for individual subunits in development, and demonstrate changes in gene expression patterns and specific metabolite levels in med18 and med25, which can explain their phenotypes. We find that med18 displays levels of phytoalexins normally found in wild type plants only after exposure to pathogens. Our results indicate that different Mediator subunits are involved in specific signaling pathways that control developmental processes and tolerance to pathogen infections.

  • Karlsson, Tommy
    et al.
    Executive, Länsstyrelser, Länsstyrelsen Östergötland.
    Bjelke, Ulf
    Executive, Universitet, Swedish University of Agricultural Sciences.
    Inventering av grön flodtrollslända Ophiogomphus cecilia 2015 – metodiktest, förstudie och första provtillfälle inom biogeografisk uppföljning2015Report (Other academic)
    Abstract [en]

    The member countries in the European Union is obliged to report the conservation status for species listed in Habitat directive every 6th year. To gather information about population sizes and trends for the species in Sweden, the Swedish Environmental Protection Agency funds a monitoring namned "Biogeographical monitoring". The County Adminstrative Board of Östergötland has been assigned to coordinate the biogeographical monitoring of dragonflies (Odonata) and diving beetles (Dytiscidae) listed in the Habitat directive in Sweden. As a first step for establishing a monitoring programme for Ophiogomphus cecilia, a survey and method test was performed during the summer 2015. This report presents the result from the survey and suggests a strategy for monitoring the species.

    Ophiogomphus cecilia is restricted to the rivers (with tributaries) Råneälven, Kalixälven and Torneälven in the Sweden. These rivers are situated in the northeastern part of Sweden and are large rivers (often >100 meters width), unregulated and mainly surrounded by woodland, but near the coast to some extent also by cultivated land. The species is redlisted as "Near threatened" (NT) in Sweden due to small distribution area.

    The aim of this study was to test exuviae-search as a survey method and act as a pilot study to receive more information about timescale, costs and practical considerations. If the survey turned out well, it could also serve as a first sample in the monitoring programme. The survey was performed by Tommy Karlsson, the County Administrative Board of Östergötland and Ulf Bjelke, the Species Species Information Centre during the period 20-24 July 2015. A large number of previously known localities for the species were surveyed as well as new, potential localities. The latter category also includes rivers from which the species not was known.

    In total, 57 localities were surveyed och O. cecilia was found at 13 of these (Tab. 1 and Fig. 2). Exuviae were found at all localities, in total 50 exuviae. They were mainly found up to 30 cm height at straws of Carex sp. and within 50 cm from the shoreline. However, 15 exuviae were found 100-400 cm from the shoreline. This was probably due to a higher water level when the dragonflies emerged. Adults were found at three localities, in total four individuals, all newly emerged and close to the exuvia. In addition, an adult was found on the roadside during car driving and wings from an individual, probably predated by a bird, was found at one locality. All visited localities are shortly described and showed in a map in annex 1 (Bilaga 1). Localities where O. cecilia were found is also presented with a picture of the habitat.

    We assess searching for exuviae as the most appropriate method for monitoring O. cecilia in Sweden. It is a quick method since the exuviae are easy to find and the risk of mixing up with other dragonflies species is very low. No other species of the family Gomphidae coexist with O. cecilia in Sweden, and the other species that you could find exuviae of at localities for O. cecilia (Aeshna sp. Somatochlora metallica, Cordulegaster boltonii) are easy to distinguish (Fig. 3-5). Furthermore, big advantages with surveying exuviae compared to adults is that it is not dependent of the weather and that records of exuviae gives information about the reproduction habitat for the species.

    Searching for exuviae is a common survey method for O. cecilia in several other European countries, and the number of observed exuviae during a certain length of a river (e.g. 50 or 100 meters) is often used to estimate status and trend for a population. However, the trend for the Swedish population is assumed to be stable and annual variation, when the surveyed is performed in relation to emergence and variation between surveyors would probably influence the result more than possible trends with the economic resources available for monitoring today. An appropriate strategy for monitoring O. cecilia in Sweden is instead to recurring detect occurrence of the species at a selected number of localities. In table 2 and figure 6, 20 localities for monitoring are suggested. 3

  • Sveriges friluftskommun 2017 enkätsvar2017Data set
    Abstract [sv]

    Enkätdata med underlag till rapport Sveriges friluftskommun 2017

  • Chatzittofis, Andreas
    et al.
    Savard, Josephine
    Arver, Stefan
    Görts Öberg, Katarina
    Hallberg, Jonas
    Nordström, Peter
    Jokinen, Jussi
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry. Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Interpersonal violence, early life adversity, and suicidal behavior in hypersexual men2017In: Journal of Behavioral Addictions, ISSN 2062-5871, E-ISSN 2063-5303, Vol. 6, no 2, 187-193 p.Article in journal (Refereed)
    Abstract [en]

    Background and aims: There are significant gaps in knowledge regarding the role of childhood adversity, interpersonal violence, and suicidal behavior in hypersexual disorder (HD). The aim of this study was to investigate interpersonal violence in hypersexual men compared with healthy volunteers and the experience of violence in relation to suicidal behavior. Methods: This case-control study includes 67 male patients with HD and 40 healthy male volunteers. The Childhood Trauma Questionnaire-Short Form (CTQ-SF) and the Karolinska Interpersonal Violence Scale (KIVS) were used for assessing early life adversity and interpersonal violence in childhood and in adult life. Suicidal behavior (attempts and ideation) was assessed with the Mini-International Neuropsychiatric Interview (version 6.0) and the Montgomery-Asberg Depression Rating Scale - Self-rating. Results: Hypersexual men reported more exposure to violence in childhood and more violent behavior as adults compared with healthy volunteers. Suicide attempters (n = 8, 12%) reported higher KIVS total score, more used violence as a child, more exposure to violence as an adult as well as higher score on CTQ-SF subscale measuring sexual abuse (SA) compared with hypersexual men without suicide attempt. Discussion: Hypersexuality was associated with interpersonal violence with higher total scores in patients with a history of suicide attempt. The KIVS subscale exposure to interpersonal violence as a child was validated using the CTQ-SF but can be complemented with questions focusing on SA for full assessment of early life adversity. Conclusion: Childhood adversity is an important factor in HD and interpersonal violence might be related to suicidal behavior in hypersexual men.

  • Li, Zhen
    et al.
    De La Torre, Amanda R.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences. Department of Plant Sciences, University of California-Davis, Davis, CA.
    Sterck, Lieven
    Cánovas, Francisco M.
    Avila, Concepción
    Merino, Irene
    Antonio Cabezas, Jose
    Teresa Cervera, Maria
    Ingvarsson, Pär K.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences. Department of Plant Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden.
    Van de Peer, Yves
    Single-Copy Genes as Molecular Markers for Phylogenomic Studies in Seed Plants2017In: Genome Biology and Evolution, ISSN 1759-6653, E-ISSN 1759-6653, Vol. 9, no 5, 1130-1147 p.Article in journal (Refereed)
    Abstract [en]

    Phylogenetic relationships among seed plant taxa, especially within the gymnosperms, remain contested. In contrast to angio-sperms, for which several genomic, transcriptomic and phylogenetic resources are available, there are few, if any, molecular markers that allow broad comparisons among gymnosperm species. With few gymnosperm genomes available, recently obtained transcriptomes in gymnosperms are a great addition to identifying single-copy gene families as molecular markers for phylogenomic analysis in seed plants. Taking advantage of an increasing number of available genomes and transcriptomes, we identified single-copy genes in a broad collection of seed plants and used these to infer phylogenetic relationships between major seed plant taxa. This study aims at extending the current phylogenetic toolkit for seed plants, assessing its ability for resolving seed plant phylogeny, and discussing potential factors affecting phylogenetic reconstruction. In total, we identified 3,072 single-copy genes in 31 gymnosperms and 2,156 single-copy genes in 34 angiosperms. All studied seed plants shared 1,469 single-copy genes, which are generally involved in functions like DNA metabolism, cell cycle, and photosynthesis. A selected set of 106 single-copy genes provided good resolution for the seed plant phylogeny except for gnetophytes. Although some of our analyses support a sister relationship between gnetophytes and other gymnosperms, phylogenetic trees from concatenated alignments without 3rd codon positions and amino acid alignments under the CAT + GTR model, support gnetophytes as a sister group to Pinaceae. Our phylogenomic analyses demonstrate that, in general, single-copy genes can uncover both recent and deep divergences of seed plant phylogeny.

  • Sahu, Sanjaya Kumar
    et al.
    Kumar, Manish
    Chakraborty, Sohini
    Banerjee, Srijon Kaushik
    Kumar, Ranjeet
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Department of Chemistry, Bose Institute, Kolkata, India.
    Gupta, Pushpa
    Jana, Kuladip
    Gupta, Umesh D.
    Ghosh, Zhumur
    Kundu, Manikuntala
    Basu, Joyoti
    MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBP beta regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection2017In: PLoS Pathogens, ISSN 1553-7366, E-ISSN 1553-7374, Vol. 13, no 5, e1006410Article in journal (Refereed)
    Abstract [en]

    For efficient clearance of Mycobacterium tuberculosis (Mtb), macrophages tilt towards M1 polarization leading to the activation of transcription factors associated with the production of antibacterial effector molecules such as nitric oxide (NO) and proinflammatory cytokines such as interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha). At the same time, resolution of inflammation is associated with M2 polarization with increased production of arginase and cytokines such as IL-10. The transcriptional and post-transcriptional mechanisms that govern the balance between M1 and M2 polarization, and bacteria-containing processes such as autophagy and trafficking of Mtb to lysosomes, are incompletely understood. Here we report for the first time, that the transcription factor KLF4 is targeted by microRNA-26a (miR-26a). During Mtb infection, downregulation of miR-26a (observed both ex vivo and in vivo) facilitates upregulation of KLF4 which in turn favors increased arginase and decreased iNOS activity. We further demonstrate that KLF4 prevents trafficking of Mtb to lysosomes. The CREB-C/EBP beta signaling axis also favors M2 polarization. Downregulation of miR-26a and upregulation of C/ebpbeta were observed both in infected macrophages as well as in infected mice. Knockdown of C/ebpbeta repressed the expression of selected M2 markers such as Il10 and Irf4 in infected macrophages. The importance of these pathways is substantiated by observations that expression of miR-26a mimic or knockdown of Klf4 or Creb or C/ebpbeta, attenuated the survival of Mtb in macrophages. Taken together, our results attribute crucial roles for the miR-26a/KLF4 and CREB-C/EBP beta signaling pathways in regulating the survival of Mtb in macrophages. These studies expand our understanding of how Mtb hijacks host signaling pathways to survive in macrophages, and open up new exploratory avenues for host-targeted interventions.

  • Billqvist, Magnus
    et al.
    Executive, Länsstyrelser, Länsstyrelsen Östergötland.
    Odonata, Media
    Executive, Länsstyrelser, Länsstyrelsen Östergötland.
    Genomgång och digitalisering av trollsländor och dykarskalbaggar på Lunds Zoologiska museum2016Report (Other academic)
    Abstract [sv]

    Samlingarna av ej tidigare registrerade och i många fall ej artbestämda trollsländor och dykare på Biologiska Museet, Lunds universitet, har gåtts igenom, och ur materialet har arter förekommande i art- och habitatdirektivet sorterats ut.

    Fem av de sex i Sverige påträffade arterna trollsländor listade i direktivet påträffades: grön mosaikslända Aeshna viridis (18 fynd registrerades), grön flodtrollslända Ophiogomphus cecilia (9), pudrad kärrtrollslända Leucorrhinia albifrons (69), bred kärrtrollslända Leucorrhinia caudalis (21) och citronfläckad kärrtrollslända Leucorrhinia pectoralis (39). (Den sjätte arten, sibirisk vinterflickslända Sympecma paedisca, är i Sverige endast påträffad tillfälligt och saknas därför i samlingarna.)

    Båda de eftersökta arterna dykarskalbaggar påträffades: bredkantad dykare Dytiscus latissimus (39) och bred paljettdykare Graphoderus bilineatus (33).

    Det finns ett mycket stort material så uppdraget har fokuserats på att registrera de fynd av de berörda arterna som härrör från olika lokaler och landskap, och de som ej tidigare registrerades av ArtDatabanken 1998 (Ragnar Hall 1998). Kollekterna bestod i olika typer av material; monterade trollsländor och dykare, trollsländor i konvolut, djur i sprit, larver och larvhudar. Den här studien begränsades till monterat material och material i konvolut. Djur i sprit, larver och larvhudar kan vid behov ses över. Samtliga kollekter som registrerats har också individmärkts med museets etiketter.

  • Ding, Ming
    et al.
    Huang, Tao
    Bergholdt, Helle K. M.
    Nordestgaard, Borge G.
    Ellervik, Christina
    Qi, Lu
    Frazier-Wood, Alexis C.
    Aslibekyan, Stella
    North, Kari E.
    Voortman, Trudy
    Graff, Mariaelisa
    Smith, Caren E.
    Lai, Chao-Qiang
    Varbo, Anette
    Lemaitre, Rozenn N.
    de Jonge, Ester A. L.
    Fumeron, Frederic
    Corella, Dolores
    Wang, Carol A.
    Tjonneland, Anne
    Overvad, Kim
    Sorensen, Thorkild I. A.
    Feitosa, Mary F.
    Wojczynski, Mary K.
    Kahonen, Mika
    Ahmad, Shafqat
    Renström, Frida
    Umeå University, Faculty of Medicine, Department of Biobank Research. Department of Clinical Sciences, Lund University, Malmö, Sweden.
    Psaty, Bruce M.
    Siscovick, David S.
    Barroso, Ines
    Johansson, Ingegerd
    Umeå University, Faculty of Medicine, Department of Biobank Research.
    Hernandez, Dena
    Ferrucci, Luigi
    Bandinelli, Stefania
    Linneberg, Allan
    Sandholt, Camilla Helene
    Pedersen, Oluf
    Hansen, Torben
    Schulz, Christina-Alexandra
    Sonestedt, Emily
    Orho-Melander, Marju
    Chen, Tzu-An
    Rotter, Jerome I.
    Allison, Mathew A.
    Rich, Stephen S.
    Sorli, Jose V.
    Coltell, Oscar
    Pennell, Craig E.
    Eastwood, Peter R.
    Hofman, Albert
    Uitterlinden, Andre G.
    Zillikens, MCarola
    van Rooij, Frank J. A.
    Chu, Audrey Y.
    Rose, Lynda M.
    Ridker, Paul M.
    Viikari, Jorma
    Raitakari, Olli
    Lehtimaki, Terho
    Mikkila, Vera
    Willett, Walter C.
    Wang, Yujie
    Tucker, Katherine L.
    Ordovas, Jose M.
    Kilpelainen, Tuomas O.
    Province, Michael A.
    Franks, Paul W.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA; Department of Clinical Sciences, Lund University, Malmö, Sweden.
    Arnett, Donna K.
    Tanaka, Toshiko
    Toft, Ulla
    Ericso, Ulrika
    Franco, Oscar H.
    Mozaffarian, Dariush
    Hu, Frank B.
    Chasman, Daniel I.
    Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study2017In: BMJ. British Medical Journal, E-ISSN 1756-1833, Vol. 356, j1000Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE To examine whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal. DESIGN Mendelian randomization study using the single nucleotide polymorphism rs4988235 related to lactase persistence as an instrumental variable. SETTING CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium. PARTICIPANTS Data from 22 studies with 171 213 participants, and an additional 10 published prospective studies with 26 119 participants included in the observational analysis. MAIN OUTCOME MEASURES The instrumental variable estimation was conducted using the ratio of coefficients approach. Using metaanalysis, an additional eight published randomized clinical trials on the association of dairy consumption with systolic blood pressure were summarized. RESULTS Compared with the CC genotype (CC is associated with complete lactase deficiency), the CT/TT genotype (TT is associated with lactose persistence, and CT is associated with certain lactase deficiency) of LCT-13910 (lactase persistence gene) rs4988235 was associated with higher dairy consumption (0.23 (about 55 g/day), 95% confidence interval 0.17 to 0.29) serving/day; P<0.001) and was not associated with systolic blood pressure (0.31, 95% confidence interval -0.05 to 0.68 mm Hg; P=0.09) or risk of hypertension (odds ratio 1.01, 95% confidence interval 0.97 to 1.05; P=0.27). Using LCT-13910 rs4988235 as the instrumental variable, genetically determined dairy consumption was not associated with systolic blood pressure (beta=1.35, 95% confidence interval -0.28 to 2.97 mm Hg for each serving/day) or risk of hypertension (odds ratio 1.04, 0.88 to 1.24). Moreover, meta-analysis of the published clinical trials showed that higher dairy intake has no significant effect on change in systolic blood pressure for interventions over one month to 12 months (intervention compared with control groups: beta=-0.21, 95% confidence interval -0.98 to 0.57 mm Hg). In observational analysis, each serving/day increase in dairy consumption was associated with -0.11 (95% confidence interval -0.20 to -0.02 mm Hg; P=0.02) lower systolic blood pressure but not risk of hypertension (odds ratio 0.98, 0.97 to 1.00; P=0.11). CONCLUSION The weak inverse association between dairy intake and systolic blood pressure in observational studies was not supported by a comprehensive instrumental variable analysis and systematic review of existing clinical trials.

  • Leino, Marina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology. Uppsala Univ Hosp, Dept Pathol, Uppsala, Sweden..
    Popova, Svetlana
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology. Uppsala Univ Hosp, Dept Pathol, Uppsala, Sweden..
    Alafuzoff, Irina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology. Uppsala Univ Hosp, Dept Pathol, Uppsala, Sweden..
    Transactive DNA Binding Protein 43 Rather Than Other Misfolded Proteins in the Brain is Associated with Islet Amyloid Polypeptide in Pancreas in Aged Subjects with Diabetes Mellitus2017In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 59, no 1, 43-56 p.Article in journal (Refereed)
    Abstract [en]

    A link between diabetes mellitus (DM) related islet amyloid polypeptide (IAPP) and Alzheimer's disease (AD) related amyloid-beta (A beta) has been suggested in epidemiological and clinical studies. In 2017, proof for existing interaction between type 2 DM and AD on a molecular level was provided based on research carried out in experimental animal models. We assessed aging-related neurodegenerative lesions, i.e., misfolded proteins, associated with dementia such as hyperphosphorylated tau (HP tau), A beta, alpha-synuclein (alpha S), and phosphorylated transactive DNA binding protein 43 (pTDP43) seen in the brain and IAPP seen in the pancreas in subjects with and without DM applying immunohistochemical techniques. HP tau in the brain and IAPP in the pancreas were observed in most subjects. The prevalence and the extent of all misfolded proteins increased with age but this increase was not influenced by DM. Interestingly the extent of misfolded proteins in the brain was higher in non-diabetics when compared with diabetics in demented. A significant correlation was observed between HP tau, A beta, alpha S, and pTDP43, whereas IAPP showed no association with HP tau, A beta, and alpha S. In subjects with DM, the extent of pTDP43 in brain correlated with the extent of IAPP in pancreas. Thus, there is no evidence of a link between AD-related pathology and DM in humans, whereas an association was found between pTDP43 and IAPP in DM. TDP43 is ubiquitously expressed in all organs but whether TDP43 is phosphorylated in other organs in DM or whether the phosphorylation of TDP43 is influenced by glucose metabolism is yet unknown.

  • Löfstrand, Tord
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology. Umeå University, Faculty of Medicine, Department of Medical Biosciences, Physiological chemistry. Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
    Determination of gestational age and lung maturity: phospholipids, creatinine and phosphatase in amniotic fluid1976Doctoral thesis, comprehensive summary (Other academic)
  • Boquist, Lennart
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    The endocrine pancreas in the Chinese hamster: studies on non-diabetic, alloxan-treated, zinc-deficient, and spontaneously diabetic animals1969Doctoral thesis, comprehensive summary (Other academic)
  • Zgela, Denis
    et al.
    CMA Research.
    Nilsson, Josefine
    CMA Research.
    Sveriges friluftskommun 20172017Report (Other academic)
    Abstract [sv]

    Kommunerna har en nyckelroll i att utveckla friluftslivet och många kommuner arbetar aktivt med friluftslivet till nytta och nöje för befolkningens välbefinnande och naturkontakt. Detta arbete vill Naturvårdsverket stimulera och genomför därför en undersökning av kommunernas friluftslivsarbete och delar ut priset till Sveriges friluftskommun. Priset delas ut av Naturvårdsverket i samarbete med Svenskt Friluftsliv och Sveriges Kultur- och Fritidschefers förening. I rapporten kan du läsa om hur de svenska kommunerna arbetar med friluftsliv i dag. Frågorna är fokuserade på planer för friluftsliv, information och samarbete kring friluftsliv samt aktiviteter inom friluftsliv. I år har vi en öppen fråga om vad som är kommunens tre bästa/viktigaste åtgärderna för att främja barn och ungas utevistelse i naturen i olika åldersgrupper. Undersökningen är genomförd de senaste sju åren och vi har jämfört resultaten mellan åren för att kunna se utvecklingen i arbetet. Det är många kommuner som visar stora förbättringar och många hamnar högt upp i poänglistan och det är väldigt glädjande. Vår förhoppning är att arbetet med Sveriges friluftskommun ska stimulera än fler att arbeta aktivt och planerat med friluftsliv.

  • Perris, Hjördis
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
    A multifactorial study of life events in depressed patients1982Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The aim of this study was an attempted elucidation of the possible pathogenic role of life events in the onset and development of depression. Although several authors seem to agree that the impact of life events should be seen in relation to the person experiencing them, no comprehensive studies have been published so far where life events have been analysed in relation to the vulnerability of the individual who becomes depressed. The present study was inspired by Freud’s concept of ”Ergänzungsreihe”, and was based on the general assumption that biological as well as psychological and social factors contribute greatly to modifying an individual’s vulnerability to external events.

    To test this hypothesis the occurrence of life events was studied by means of a semistructured interview in a consecutive series of 206 depressed patients of both sexes treated as in- or outpatients* and the results have been analysed in relation to a series of variables which could be assumed to be of importance in modifying the vulnerability of the patients. The main hypothesis was that the more vulnerable the individual was in relation to each of the investigated factors, the fewer events would be necessary to produce a depressive breakdown and the more negative would be the experience of such events. Biological, psychological and clinical variables were taken into account in different parts of the present study.

    The results support the view that the impact of life events should be seen idiosyncratically and in relation to the specific vulnerability of each individual. Furthermore the study illustrates a fruitful approach for further studies aimed at a closer understanding of the role of external events in the development of a depressive illness.

  • Olsen, Renate S.
    et al.
    Division of Medical Diagnostics, Department of Laboratory Medicine, Region Jönköping County, Jönköping, Sweden.
    Nijm, Johnny
    Division of Medical Diagnostics, Department of Clinical Physiology, Region Jönköping County, Jönköping, Sweden.
    Andersson, Roland E.
    Department of Surgery, Region Jönköping County, Jönköping, Sweden.
    Dimberg, Jan
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
    Wågsäter, Dick
    Division of Drug Research, Department of Medicine and Health Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
    Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer2017In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 23, no 34, 6212-6219 p.Article in journal (Refereed)
    Abstract [en]

    AIM: To investigate association of circulating inflammatory factors at the time of colorectal cancer (CRC) surgery with survival.

    METHODS: Plasma levels from 174 CRC patients (69 females and 105 men), with median age 70 years (range 29-90), localized in the colon (n = 105) or rectum (n = 69), with stage I (n = 24), stage II (n = 54), stage III (n = 67) and stage IV (n = 29) were measured using commercially available Bio-Plex Pro™ Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.

    RESULTS: Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.

    CONCLUSION: High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis.

  • Näsman, Birgitta
    Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
    The limbic-hypothalamic-pituitary-adrenal axis in Alzheimer's disease1994Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Dysfunction of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis is a common finding in advanced dementia. In this study, the function of the LHPA axis at different levels was investigated in patients with dementia and in healthy elderly.

    A subtle disturbance in the feedback regulation of the LHPA axis was found in patients with early (i.e., mild to moderate) Alzheimer’s disease (AD). After 0.5 mg dexamethasone, serum cortisol levels were less suppressed in AD patients and plasma adrenocorticotropin (ACTH) levels were lower as compared with healthy elderly. After stimulation with human corticotropin-releasing hormone a blunted ACTH response was found in AD patients while relative serum cortisol, déhydroépiandrostérone, and androstenedione responses were increased. Significant correlations were found between low plasma ACTH levels and temporal lobe atrophy and between low peak plasma ACTH levels and hippocampal atrophy measured with computer tomography. Patients with advanced AD and multi-infarct dementia had lower basal levels of déhydroépiandrostérone sulphate in combination with no difference in cortisol levels, resulting in a high cortisol/DHAS ratio. The difference persisted after adjustments for age and sex in a multivariate analysis. In patients with early AD, basal serum levels of dehydroepiandrosterone and androstenedione were increased, and this increase was accentuated after stimulation with ACTH. Peripheral glucocorticoid sensitivity was examined by skin vasoconstrictor blanching tests. Patients with AD and patients treated with glucocorticoids showed skin blanching at higher clobetasol concentrations than healthy elderly.

    These findings justify further investigations on the role of LHPA axis dysfunction in Alzheimer’s disease and its possible importance for the pathophysiology of the disease.

  • Korsman, Tom
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Acidification trends in Swedish lakes: an assessment of past water chemistry conditions using lake sediments1993Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis presents temporal perspectives of lake acidification in Sweden. Sediment records have been used to study timing, trends and causes of acidification, and two different techniques for assessing past lake-water acidity are presented.

    A new technique for pH prediction, based on near-infrared (NIR) spectroscopy of surface sediments, is developed. This study shows that there is a pH related fraction of lake sediments that can be recorded by NIR analysis. Relationships between NIR spectra of surface sediment samples and measured lake-water pH values, and between NIR spectra of sediment cores and historical pH values inferred by diatom analysis, are modelled by partial least squares regression. The prediction errors of the models are comparable to those obtained by modelling of diatom and lake-water pH data. By further development NIR spectroscopy can become useful for inferring past pH, as well as several other lake-water parameters, from sediment cores.

    Diatom-based predictive models, using multivariate calibration methods, are developed for inferences of lake-water pH, alkalinity and colour. These models are used to provide a regional assessment of recent lake acidification in the provinces of Västerbotten and Norrbotten, northern Sweden. The study shows that a pH decline has occurred in some southeastern lakes, but that most of the lakes have not faced significant changes in lake-water pH, alkalinity and colour. The inferred water chemistiy changes are discussed in relation to atmospheric deposition and land-use.

    In a study of eight acid-sensitive Swedish boreal-forest lakes a past-analogue approach is used to test whether contemporary expansion of conifers could cause lake acidification. Water chemistry changes associated with the natural pre-historic colonization and expansion of spruce in Sweden (—3000 years B.P.), at times of background atmospheric acidity, are inferred to evaluate the acidification ability of spruce per se on surface waters. This study shows that under natural, unpolluted conditions spruce colonization and expansion did not cause lake acidification.

    In a synthesis of palaeolimnological acidification research in Sweden a general model for pH- development for acid clear-water lakes in southern Sweden is presented. The pH-development from the last déglaciation to present time can be divided into four different periods; (i) a natural long-term acidification period (12000 B.P. - 2300 B.P., or later), with a gradual decrease in pH resulting from declining fluxes of base cations from catchment soils; (ii) a human induced alkalization period (2300 B.P. - 1900 A.D.), with a pH increase due to human activities in the catchments; (iii) the recent acidification period (about 1900 A.D. - present), when pH decreased towards 4.5 due to acid deposition and possibly ceased land-use; and (iv) the liming period (1970s - present), when pH often increases to values above 7 following lime treatment to counteract acidification. The implications of these past pH changes for the concept of contemporary lake acidification and for liming policy are outlined.

  • Bergman, Maud
    Umeå University, Faculty of Medicine, Department of Odontology. Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Chemical and thermodynamic studies of dental gold alloys with special reference to homogenization, electrochemical corrosion and cluster formation1976Doctoral thesis, comprehensive summary (Other academic)
  • Ahlm, Clas
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Distribution of puumala virus in Sweden1997Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Puumala virus, belonging to the genus hantavirus, is the causative agent of nephropathia epidemica (NE), a relatively mild form of hemorrhagic fever with renal syndrome. Puumala virus occurs endemically in Central and Northern Europe and Western Russia. In Sweden, NE is reported from the northern and central parts but virtually not at all from the southern part of the country. The bank vole (Clethrionomys glareolus) is the main reservoir of Puumala virus and humans are infected by inhalation of aerosolized animal secreta. In northern Sweden, the density of the bank vole population varies cyclically in intervals of 3-4 years and the incidence of NE shows a covariation.

    The prevalence of serum antibodies to hantaviruses in northern Sweden was studied in a stratified and randomly selected adult population sample comprising 1538 subjects. As expected, the prevalence increased with age. There was no difference between men and women, which was unexpected based on a male:female ratio of > 2:1 in clinical reports. By use of an immunofiuorescent assay, a seroprevalence of 5.4% and by a newly developed enzyme-linked immunosorbent assay (ELISA) with recombinant Puumala virus nucleocapsid protein as antigen, a prevalence of 8.9% was recorded. This is about or more than ten times higher than what would be calculated from clinical reports.

    By use of the ELISA, an occupational risk of acquisition of Puumala virus infection was demonstrated. Serum samples from 910 farmers and 663 referent subjects living in various rural parts of Sweden were tested. Among farmers from the Puumala virus-endemic northern and central parts of the country, the seroprevalence (12.9%) was higher (p=0.01) than in referents (6.8%). In the southern part of Sweden, only 2/459 persons had antibodies. Only a limited number of children with NE had been previously reported. In a separate study, 32 children with Puumala virus infection were identified and the clinical picture of NE in children was found to be similar to that of adult cases.

    Variations in the prevalence of Puumala virus in the bank vole population within an endemic region are not well known. Here, a higher mean rodent density and a higher prevalence of Puumala virus-specific serum antibodies were recorded in the vicinity of households afflicted with NE than in rural control areas. The data indicated that the risk of exposure locally within an endemic region may vary widely and tentatively suggested that a threshold density of bank voles might be necessary to achieve before effective spread of Puumala virus within the rodent population may occur.

    There is no firm evidence of the occurrence of Puumala virus among wild living animals other than rodents. A study of Swedish moose, an animal which is ecologically well characterized, was performed. Convincing evidence of past Puumala virus infection was found in 5/260 moose originating from Puumala virus-endemic areas but in none of 167 animals from nonendemic areas. Based on the low seroprevalence recorded, moose seemed to serve as endstage hosts rather than being active parts of the enzootic circle of transmission.

    In conclusion, the present investigations confirmed that the exposure to Puumala virus is geographically well restricted in Sweden. Seroprevalence studies indicated that only a minor proportion of individuals infected with Puumala virus are clinically reported, with a bias in favour of men. NE was confirmed to occur in children, with a clinical picture similar to that of adults. An occupational risk was defined for acquisition of Puumala virus infection. Studies in rodents suggested that there may be wide local variations within a limited area in the risk of exposure to Puumala virus. The studies validated the usefulness of a newly developed ELISA based on recombinant nucleocapsid peptides of hantaviruses and finally, methodological progress was reached when Puumala virus was, for the first time, successfully isolated from a Scandinavian patient.

  • Edenborg, Emil
    Södertörn University, Centre for Baltic and East European Studies (CBEES). Södertörn University, School of Social Sciences, Political Science.
    Sörberg, Anna-Maria, 2017. Homo­nationalism. Stockholm: Leopard förlag.2017In: Statsvetenskaplig Tidskrift, ISSN 0039-0747, Vol. 119, no 2, 338-341 p.Article, book review (Other academic)
  • Annadotter, Kerstin
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Real Estate and Construction Management, Building and Real Estate Economics.
    Werner, Inga Britt
    KTH, School of Architecture and the Built Environment (ABE), Urban Planning and Environment, Urban and Regional Studies.
    Sammanfattande rapport: Projekt Grannskapseffekter på områdesnivå-en fördjupad studie av bostadsrättsombildning i allmännyttan2017Report (Other academic)
  • Stegmayr, Bernd
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Dialysis Procedures Alter Metabolic Conditions2017In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 9, no 6, 548Article, review/survey (Refereed)
    Abstract [en]

    A progressive chronic kidney disease results in retention of various substances that more or less contribute to dysfunction of various metabolic systems. The accumulated substances are denominated uremic toxins. Although many toxins remain undetected, numerous newly defined toxins participate in the disturbance of food breakdown. In addition, toxic effects may downregulate other pathways, resulting in a reduced ability of free fatty acid breakdown by lipoprotein lipase (LPL) and hepatic lipase (HL). Dialysis may even worsen metabolic functions. For LPL and HL, the use of heparin and low molecular weight heparin as anticoagulation during hemodialysis (HD) initiate a loss of these enzymes from their binding sites and degradation, causing a temporary dysregulation in triglyceride breakdown. This lack of function will cause retention of the triglyceride containing lipids for at least 8 h. In parallel, the breakdown into free fatty acids is limited, as is the energy supply by them. This is repeated thrice a week for a normal HD patient. In addition, dialysis will cause a loss of amino acids and disturb glucose metabolism depending on the dialysates used. The addition of glucose in the dialysate may support oxidation of carbohydrate and the retention of Amadori products and subsequent tissue alterations. To avoid these effects, it seems necessary to further study the effects of anticoagulation in HD, the extent of use of glucose in the dialysate, and the supplementation of amino acids.

  • Wilson, Max, L.
    et al.
    Tony, Russell-Rose,Birger, Larsen,Hansen, PrebenStockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.Kristian, Norling,
    Proceedings of the 3rd European Workshop on Human-Computer Interaction and Information Retrieval2013Collection (editor) (Other (popular science, discussion, etc.))
  • Tedre, Matti
    Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
    Competing Claims to Computing as a Discipline (Invited talk)2015In: 15th Congress of Logic, Methodology and Philosophy of Science, University of Helsinki , 2015Conference paper (Refereed)
  • Stirna, Janis
    Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
    Capability Driven Development of Context-aware Enterprise Applications – Challenges, Approach and Experiences2015In: 5th Enterprise Engineering Working Conference, CIAO! Network , 2015Conference paper (Refereed)
    Abstract [en]

    Enterprises are facing the need to adapt their businesses according to various situations in which their applications need to be used. To answer this challenge an EU FP7 project “Capability as a Service in digital enterprises” (CaaS) has been initiated. The aim of CaaS is to support the capture and analysis of changing business context in the design of information systems (IS) using the capability notion. Capability is seen as the ability and capacity that enables an enterprise to achieve a business goal in a certain context. The key rationale behind a capability driven approach is to capture the dependence of organizational and IS designs on application context and to provide explicit support for run-time adjustments according to changes in the application situation. The CaaS project is developing a methodology and a tool environment for capability driven development. We envision to further advance the service oriented paradigm and to develop context aware business capabilities by using Enterprise Modelling techniques as a starting point of the development process, capability design patterns for reuse of best practices, as well as composition of required capabilities and algorithms for run-time adjustment. This talk will address the main principles of the capability driven development methodology, as well as present the current experiences of capability design in three use case companies of the CaaS project – SIV AG (Germany) for business process outsourcing, Fresh T Limited (UK) for compliance management, and Everis (Spain) for capability management in e-government platforms.

  • Mattsson, Anna
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology. Ctr Reprod Biol Uppsala CRU, Uppsala, Sweden..
    Brunström, Björn
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology. Ctr Reprod Biol Uppsala CRU, Uppsala, Sweden..
    Effects of selective and combined activation of estrogen receptor α and β on reproductive organ development and sexual behaviour in Japanese quail (Coturnix japonica)2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 7, e0180548Article in journal (Refereed)
    Abstract [en]

    Excess estrogen exposure of avian embryos perturbs reproductive organ development in both sexes and demasculinizes the reproductive behaviors of adult males. We have previously shown that these characteristic effects on the reproductive organs also can be induced by exposure of Japanese quail (Coturnix japonica) embryos to selective agonists of estrogen receptor alpha (ER alpha). In contrast, the male copulatory behavior is only weakly affected by developmental exposure to an ERa agonist. To further elucidate the respective roles of ER alpha and ER beta in estrogen-induced disruption of sexual differentiation, we exposed Japanese quail embryos in ovo to the selective ER alpha agonist 16 alpha-lactone-estradiol (16 alpha LE2), the selective ER beta agonist WAY-200070, or both substances in combination. The ERa agonist feminized the testes in male embryos and reduced cloacal gland size in adult males. Furthermore, anomalous retention and malformations of the Mullerian ducts/oviducts were seen in embryos and juveniles of both sexes. The ER beta agonist did not induce any of these effects and did not influence the action of the ERa agonist. Male copulatory behavior was not affected by embryonic exposure to either the ER alpha-or the ER beta-selective agonist but was slightly suppressed by treatment with the two compounds combined. Our results suggest that the reproductive organs become sexually differentiated consequent to activation of ER alpha by endogenous estrogens; excessive activation of ER alpha, but not ER beta, during embryonic development may disrupt this process. Our results also suggest that the demasculinizing effect of estrogens on male copulatory behavior is only partly mediated by ER alpha and ER beta, and may rather involve other estrogen-responsive pathways.