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  • Yang, Lei
    et al.
    Univ Oslo, Dept Phys, Sem Soelands Vei 24,Postbox 1048, N-0317 Oslo, Norway..
    Paulsson, J. J. P.
    Univ Oslo, Dept Phys, Sem Soelands Vei 24,Postbox 1048, N-0317 Oslo, Norway..
    Wedlund, C. Simon
    Univ Oslo, Dept Phys, Sem Soelands Vei 24,Postbox 1048, N-0317 Oslo, Norway..
    Odelstad, Elias
    Uppsala universitet, Institutet för rymdfysik, Uppsalaavdelningen.
    Edberg, Niklas J. T.
    Uppsala universitet, Institutet för rymdfysik, Uppsalaavdelningen.
    Koenders, C.
    Tech Univ Carolo Wilhelmina Braunschweig, Inst Geophys & Extraterr Phys, Mendelssohnstr 3, D-38106 Braunschweig, Germany..
    Eriksson, Anders I.
    Uppsala universitet, Institutet för rymdfysik, Uppsalaavdelningen.
    Miloch, W. J.
    Univ Oslo, Dept Phys, Sem Soelands Vei 24,Postbox 1048, N-0317 Oslo, Norway..
    Observations of high-plasma density region in the inner coma of 67P/Churyumov-Gerasimenko during early activity2016In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 462, p. S33-S44Article in journal (Refereed)
    Abstract [en]

    In 2014 September, as Rosetta transitioned to close bound orbits at 30 km from comet 67P/Churyumov-Gerasimenko, the Rosetta Plasma Consortium Langmuir probe (RPC-LAP) data showed large systematic fluctuations in both the spacecraft potential and the collected currents. We analyse the potential bias sweeps from RPC-LAP, from which we extract three sets of parameters: (1) knee potential, that we relate to the spacecraft potential, (2) the ion attraction current, which is composed of the photoelectron emission current from the probe as well as contributions from local ions, secondary emission, and low-energy electrons, and (3) an electron current whose variation is, in turn, an estimate of the electron density variation. We study the evolution of these parameters between 4 and 3.2 au in heliocentric and cometocentric frames. We find on September 9 a transition into a high-density plasma region characterized by increased knee potential fluctuations and plasma currents to the probe. In conjunction with previous studies, the early cometary plasma can be seen as composed of two regions: an outer region characterized by solar wind plasma, and small quantities of pick-up ions, and an inner region with enhanced plasma densities. This conclusion is in agreement with other RPC instruments such as RPC-MAG, RPC-IES and RPC-ICA, and numerical simulations.

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  • Strömgren, Magnus
    et al.
    Umeå University, Faculty of Social Sciences, Department of Geography.
    Schantz, Peter
    Research Unit for Movement, Health and Environment, The Swedish School of Sport and Health Sciences, GIH, Stockholm, Sweden.
    Sommar, Johan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Sustainable Health.
    Raza, Wasif
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Sustainable Health.
    Markstedt, Anders
    WSP Civils, Stockholm, Sweden.
    Forsberg, Bertil
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Sustainable Health.
    Modeling commuter modal shift from car trips to cycling: Scenario construction and outcomes for Stockholm, Sweden2020In: Journal of Transport Geography, ISSN 0966-6923, E-ISSN 1873-1236, no 86, article id 102740Article in journal (Refereed)
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  • Magnusson, Peter
    et al.
    Nordström, Jonny
    Harms, Hendrik J.
    Lubberink, Mark
    Gadler, Fredrik
    Sörensen, Jens
    Mörner, Stellan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Positron emission tomography (15O-water, 11C-acetate, 11C-HED) risk markers and nonsustained ventricular tachycardia in hypertrophic cardiomyopathy2020In: IJC Heart & Vasculature, ISSN 2352-9067, Vol. 26, article id 100452Article in journal (Refereed)
    Abstract [en]

    Background: The objectives of the study were to describe positron emission tomography (PET) parameters, using the tracers 15O-water at rest/stress, 11C-acetate, and 11C-HED, with regard to nonsustained ventricular tachycardia (NSVT) in hypertrophic cardiomyopathy (HCM). PET offers quantitative assessment of pathophysiology throughout the left ventricular segments, including the endocardium/epicardium. The potential use PET in risk stratification remains to be elucidated. NSVT provides a marker for sudden cardiac death.

    Methods: Patients with a validated diagnosis of HCM who had an implantable cardioverter-defibrillator were interrogated at 12 months and independently of PET-examinations.

    Results: In total, 25 patients (mean age 56.8 ± 12.9 years, 76% males) were included and 10 reported NSVT. Mean myocardial blood flow (MBF) at rest was 0.91 ml/g/min and decreased at stress, 1.59 ml/g/min. The mean gradient (endocardium/epicardium quotient) at rest was 1.14 ± 0.09, while inverse at stress (mean 0.92 ± 0.16). Notably, MBF gradient at stress was significantly lower in patients with NSVT (p = 0.022) and borderline at rest (p = 0.059) while global MBF at rest and stress were not. Mean myocardial oxygen consumption (MVO2) was 0.088 ml/g/min (higher in NSVT, p = 0.023) and myocardial external efficiency 18.5%. Using 11C-HED, the mean retention index was 0.11 min−1 and a higher volume of distribution (p = 0.089) or transmural gradient of clearance rate (p = 0.061) or lower clearance rate (p = 0.052) showed a tendency of association of NSVT.

    Conclusions: The endocardium/epicardium MBF gradient at stress is significantly lower in HCM patients with NSVT. This provides a novel approach to further refine risk stratification of sudden cardiac death.

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  • Norman, Mikael
    et al.
    Håkansson, Stellan
    Umeå University, Faculty of Medicine, Department of Clinical Sciences. Umeå University Hospital.
    Kusuda, Satoshi
    Vento, Maximo
    Lehtonen, Liisa
    Reichman, Brian
    Darlow, Brian A.
    Adams, Mark
    Bassler, Dirk
    Isayama, Tetsuya
    Rusconi, Franca
    Lee, Shoo
    Lui, Kei
    Yang, Junmin
    Shah, Prakesh S.
    Neonatal Outcomes in Very Preterm Infants With Severe Congenital Heart Defects: An International Cohort Study2020In: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, ISSN 2047-9980, E-ISSN 2047-9980, Vol. 9, no 5, article id e015369Article in journal (Refereed)
    Abstract [en]

    Background Very preterm infants are at high risk of death or severe morbidity. The objective was to determine the significance of severe congenital heart defects (CHDs) for these risks. Methods and Results This cohort study included infants from 10 countries born from 2007-2015 at 24 to 31 weeks' gestation with birth weights <1500 g. Severe CHDs were defined by International Classification of Diseases, Ninth Revision (ICD-9) and Tenth (ICD-10) codes and categorized as those compromising systemic output, causing sustained cyanosis, or resulting in congestive heart failure. The primary outcome was in-hospital mortality. Secondary outcomes were neonatal brain injury, necrotizing enterocolitis, bronchopulmonary dysplasia, and retinopathy of prematurity. Adjusted and propensity score-matched odds ratios (ORs) were calculated. Analyses were stratified by type of CHD, gestational age, and network. A total of 609 (0.77%) infants had severe CHD and 76 371 without any malformation served as controls. The mean gestational age and birth weight were 27.8 weeks and 1018 g, respectively. The mortality rate was 18.6% in infants with CHD and 8.9% in controls (propensity score-matched OR, 2.30; 95% CI, 1.61-3.27). Severe CHD was not associated with neonatal brain injury, necrotizing enterocolitis, or retinopathy of prematurity, whereas the OR for bronchopulmonary dysplasia increased. Mortality was higher in all types, with the highest propensity score-matched OR (4.96; 95% CI, 2.11-11.7) for CHD causing congestive heart failure. While mortality did not differ between groups at <27 weeks' gestational age, adjusted OR for mortality in infants with CHD increased to 10.9 (95% CI, 5.76-20.70) at 31 weeks' gestational age. Rates of CHD and mortality differed significantly between networks. Conclusions Severe CHD is associated with significantly increased mortality in very preterm infants.

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  • Shchukarev, Andrey
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Gojkovic, Zivan
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Funk, Christiane
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Ramstedt, Madeleine
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Cryo-XPS analysis reveals surface composition of microalgae2020In: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 526, article id 146538Article in journal (Refereed)
    Abstract [en]

    Green microalgae are widely used for wastewater treatment, food/feed and pigment production, as well as for aquaculture. However, very little is known about their surface composition, which can determine algae behavior in nature and influence their processing. In this work, we use cryo-XPS to characterize the surface chemical composition of three different microalgae species. We investigate the applicability of a data treatment method, developed for bacteria, deconvoluting C 1s with respect to protein, lipid and polysaccharide. We discuss how substances unique to algae contribute to the C 1s spectra and how this affects the transferability of the method to microalgae. Two species of green microalgae isolated from Northern Sweden, Chlorella vulgaris 13-1 and Coelastrella sp. 3-4, were compared to reference culture collection strain, Scenedesmus obliquus RISE (UTEX 417). Cryo-XPS data indicate that surfaces of Coelastrella sp. 3-4 and C. vulgaris 13-1 cells are dominated by protein and carbohydrates. However, the carbohydrate content was higher for C. vulgaris. The reference strain shows the highest content of proteins and has an increased amount of lipids compared to the other two. Estimation of the cell surface hydrophobicity suggests that the hydrophobicity increases in the order: C. vulgaris < Coelastrella sp. < S. obliquus.

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  • Johansson, Håkan
    et al.
    Swedish Transport Administration.
    Eklöf, Hanna
    Swedish Transport Administration.
    Lindblom, Helen
    Swedish Road Administration.
    Kunskapsunderlag om energieffektivisering och begränsad klimatpåverkan2020Report (Other academic)
    Abstract [sv]

    Syftet med kunskapsunderlaget är att visa vad klimatmålen innebär för utvecklingen av transportsektorn och hur Trafikverket kan bidra till att klimatmålen nås. Denna version av kunskapsunderlaget utgör den fjärde, och hittills största uppdateringen, sedan Trafikverket bildades. Sedan senaste uppdateringen 2014 har Sverige bland annat antagit klimatmål för inrikes transporter, nytt nationellt klimatmål och ett klimatpolitiskt ramverk. Trafikverket har satt interna mål att infrastrukturen, inklusive färjedriften, ska vara klimatneutral senast 2045 och utifrån detta successivt infört klimatkrav i upphandlingar.

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    Kunskapsunderlag om energieffektivisering och begränsad klimatpåverkan
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  • Barut, Oya
    et al.
    Umeå University, Faculty of Medicine, Department of Odontology.
    Ahlqvist, Jan
    Umeå University, Faculty of Medicine, Department of Odontology.
    Garoff, Maria
    Umeå University, Faculty of Medicine, Department of Odontology.
    Johansson, Elias
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience. Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Johansson, Magnus
    Umeå University, Faculty of Medicine, Department of Odontology.
    Wester, Per
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Department of Clinical Sciences, Karolinska Institutet, Danderyds Hospital, Stockholm, Sweden.
    Levring Jäghagen, Eva
    Umeå University, Faculty of Medicine, Department of Odontology.
    Calcifications in the neck region of patients with carotid artery stenosis: a computed tomography angiography study of topographic anatomy2020In: Oral surgery, oral medicine, oral pathology and oral radiology, ISSN 2212-4403, E-ISSN 2212-4411, Vol. 129, no 5, p. 523-530Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: The aim of this study was to map the vertical locations of calcified carotid plaques (CCPs), osseous anatomic structures, and calcified soft tissues in the area of the carotid artery, determine to what extent CCPs are superimposed on the cervical spine in coronal images, and analyze the differences between men and women.

    STUDY DESIGN: Computed tomography angiography (CTA) scans of 79 patients were studied. CCPs were discovered in 152 of the total 158 neck sides. Evaluations were performed by using sagittal and coronal reformatted CTA images with maximum intensity projection.

    RESULTS: Most of the calcified anatomic structures studied, including the carotid bifurcation, were found in close relationship to the level of the third and fourth cervical vertebrae. In the coronal view, all or most of the areas of the CCPs were superimposed on the cervical spine in 22 of 44 (50%) neck sides with CCP in women and in 37 of 108 (34.2%) in men (P = .070).

    CONCLUSIONS: The carotid bifurcation is in close proximity to various calcified anatomic structures. This should be taken into account when diagnosing CCPs in panoramic radiographs. In the coronal view, CCPs and the cervical spine are often superimposed; thus, coronal images are not recommended for confirmation of putative carotid calcifications diagnosed on the basis of panoramic radiographs.

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  • Öhlander, Magnus
    et al.
    Wolanik Boström, Katarzyna
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Pettersson, Helena
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Knowledge Transfer Work: A Case of Internationally Mobile Medical Professionals2020In: Nordic Journal of Migration Research, ISSN 1799-649X, E-ISSN 1799-649X, Vol. 10, no 2, p. 36-49Article in journal (Refereed)
    Abstract [en]

    This article addresses the relationship between highly skilled international mobility and knowledge by focussing on knowledge transfer work. Empirically, this study is based on interviews of professionals in the Swedish medical field who returned to Sweden after a period of work in other countries. The medical field harbours many transnationally valid competences and standardised lines of work, but even in this field, knowledge transfer is a process requiring effort, skills, negotiation, translation and adjustment to the specific organisational and cultural contexts. The studied professionals’ knowledge transfer work showed a spectrum, ranging from smooth, almost friction-free transfers to the ones where much translation and transformation was required, depending on the context and the professional’s status in the workplace. The professionals also developed and made use of knowledge transfer skills, such as the ability to observe, analyse and adjust to cultural differences between workplaces, healthcare systems or academic systems, as well as the ability to translate knowledge to make it relevant and viable in the specific context.

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  • Comparotto, Corrado
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Solid-State Electronics.
    Davydova, Alexandra
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Solid-State Electronics.
    Ericson, Tove
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Solid-State Electronics.
    Riekehr, Lars
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Solid-State Electronics.
    Moro, Marcos V.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Solid-State Electronics.
    Kubart, Tomas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Solid-State Electronics.
    Scragg, Jonathan J.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Solid-State Electronics.
    Chalcogenide Perovskite BaZrS3: Thin Film Growth by Sputtering and Rapid Thermal Processing2020In: ACS APPLIED ENERGY MATERIALS, ISSN 2574-0962, Vol. 3, no 3, p. 2762-2770Article in journal (Refereed)
    Abstract [en]

    Tandem solar cells based on hybrid organic-inorganic metal halide perovskites have reached efficiencies up to 28%, but major concerns for long-term stability and the presence of Pb have raised interest in searching for fully earth-abundant, intrinsic chemically stable, and nontoxic alternatives. With a direct band gap around 1.8 eV and stability in air up to at least 500 degrees C, BaZrS3 is a promising candidate. This work presents the first approach of synthesizing a thin film of such compound by sputtering at ambient temperature with a subsequent rapid thermal process. Despite the short fabrication time, the width of the XRD diffraction peaks and the energy and distribution of the photoluminescence response show comparable crystalline quality to that from bulk synthesis methods. Good crystallization required around 900 degrees C. Such a high temperature could be incompatible with fabrication of tandem solar cells.

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  • Saak, Clara-Magdalena
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics.
    Unger, Isaak
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics.
    Gopakumar, Geethanjali
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics.
    Caleman, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics. DESY, Ctr Free Electron Laser Sci, DE-22607 Hamburg, Germany..
    Björneholm, Olle
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics.
    Temperature Dependence of X-ray-Induced Auger Processes in Liquid Water2020In: Journal of Physical Chemistry Letters, ISSN 1948-7185, E-ISSN 1948-7185, Vol. 11, no 7, p. 2497-2501Article in journal (Refereed)
    Abstract [en]

    Auger spectroscopy has previously been used to study changes in the hydrogen bond network in liquid water, but to the best of our knowledge it has not been used to track such changes as a function of temperature. We show Auger spectroscopy to reflect the weakening of the hydrogen bond network upon heating. This shows that the radiation response of water, i.e., the relative propensity of the different processes occurring after radiation exposure, including femtosecond proton dynamics, depends on the temperature of the system. This proof-of-principle study further demonstrates the suitability of the technique to help elucidate information on the intermolecular structure of liquids such as water, opening the door to further temperature-dependent studies.

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  • El Bakouri, Ouissam
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Synthetic Molecular Chemistry.
    Smith, Joshua R.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Synthetic Molecular Chemistry. Humboldt State Univ, Dept Chem, One Harpst St, Arcata, CA 95521 USA..
    Ottosson, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Synthetic Molecular Chemistry.
    Strategies for Design of Potential Singlet Fission Chromophores Utilizing a Combination of Ground-State and Excited-State Aromaticity Rules2020In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 142, no 12, p. 5602-5617Article in journal (Refereed)
    Abstract [en]

    Singlet exciton fission photovoltaic technology requires chromophores with their lowest excited states arranged so that 2E(T-1) < E(S-1) and E(S-1) < E(T-2). Herein, qualitative theory and quantum chemical calculations are used to develop explicit strategies on how to use Baird's 4n rule on excited-state aromaticity, combined with Huckel's 4n + 2 rule for ground-state aromaticity, to tailor new potential chromophores for singlet fission. We first analyze the E(T-1), E(S-1), and E(T-2) of benzene and cyclobutadiene (CBD) as excited-state antiaromatic and aromatic archetypes, respectively, and reveal that CBD fulfills the criteria on the state ordering for a singlet fission chromophore. We then look at fulvenes, a class of compounds that can be tuned by choice of substituents from Baird-antiaromatic to Baird-aromatic in T-1 and S-1 and from Huckel-aromatic to Huckel-antiaromatic in S-0. The T-1 and S-1 states of most substituted fulvenes (159 of 225) are described by singly excited HOMO -> LUMO configurations, providing a rational for the simultaneous tuning of E(T-1) and E(S-1) along an approximate (anti)aromaticity coordinate. Key to the tunability is the exchange integral (K-H,K-L), which ideally is constant throughout the compound class, providing a constant.E(S-1 - T-1). This leads us to a geometric model for the identification of singlet fission chromophores, and we explore what factors limit the model. Candidates with calculated E(T-1) values of similar to 1 eV or higher are identified among benzannelated 4npelectron compound classes and siloles. In brief, it is clarified how the joint utilization of Baird's 4n and Huckel's 4n + 2 rules, together with substituent effects (electronic and steric) and benzannelation, can be used to tailor new chromophores with potential use in singlet fission photovoltaics.

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  • Velders, Matthijs A.
    et al.
    Vastmanland Cty Hosp, Dept Med, S-72189 Sigtunagatan, Vasteras, Sweden..
    Hagström, Emil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    James, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Temporal Trends in the Prevalence of Cancer and Its Impact on Outcome in Patients With First Myocardial Infarction: A Nationwide Study2020In: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, ISSN 2047-9980, E-ISSN 2047-9980, Vol. 9, no 4, article id e014383Article in journal (Refereed)
    Abstract [en]

    Background: Coexistence of cancer and cardiovascular disease is increasingly frequent, but nationwide data covering cancer patients with myocardial infarction (MI) are scarce. We sought to investigate the prevalence of cancer in patients with first MI, and its impact on cardiovascular and bleeding outcome.

    Methods and Results: Using nationwide Swedish quality registries, all patients admitted for first MI between 2001 and 2014 were identified. Data on comorbidity, cancer, and outcome were obtained from the national cancer and patient registries. Stratification was performed according to cancer during the 5 years before MI. Multivariable Cox proportional hazards analyses adjusting for cardiovascular risk factors and invasive treatment assessed the association of cancer with outcome. In total, 175 146 patients with first MI were registered, of whom 9.3% (16 237) had received care for cancer in the 5 years before admission. The cancer rate increased from 6.7% in the years 2001-2002 to 10.7% in 2013-2014, independent of sex and cancer type. The presence of a new cancer diagnosis within 5 years increased from 4.9% to 6.2%. During a median follow-up of 4.3 years, cancer was associated with all-cause mortality (hazard ratio, 1.44; 95% CI, 1.40-1.47), recurrent MI (hazard ratio, 1.08; 95% CI, 1.041.12), heart failure (hazard ratio, 1.10; 95% CI, 1.06-1.13), and major bleeding (hazard ratio, 1.45; 95% CI, 1.34-1.57). Risk for adverse events varied strongly according to cancer extent, timing, and type.

    Conclusions: Cancer as a comorbid disorder is increasing and is strongly associated with mortality, severe bleeding, and adverse cardiovascular outcome after first MI.

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  • Spangler, Douglas
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Health Services Research. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Edmark, Lennart
    Vastmanlands Sjukhus Vasteras, Dept Anesthesia & Intens Care, Vasteras, Sweden..
    Winblad, Ulrika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Health Services Research.
    Collden-Benneck, Jessica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Borg, Helena
    Vastmanlands Sjukhus Vasteras, Ambulance Dept, Vasteras, Sweden..
    Blomberg, Hans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Using trigger tools to identify triage errors by ambulance dispatch nurses in Sweden: an observational study2020In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 10, no 3, article id e035004Article in journal (Refereed)
    Abstract [en]

    Objectives: This study aimed to assess whether trigger tools were useful identifying triage errors among patients referred to non-emergency care by emergency medical dispatch nurses, and to describe the characteristics of these patients.

    Design: An observational study of patients referred by dispatch nurses to non-emergency care.

    Setting: Dispatch centres in two Swedish regions.

    Participants: A total of 1089 adult patients directed to non-emergency care by dispatch nurses between October 2016 and February 2017. 53% were female and the median age was 61 years.

    Primary and secondary outcome measures: The primary outcome was a visit to an emergency department within 7 days of contact with the dispatch centre. Secondary outcomes were (1) visits related to the primary contact with the dispatch centre, (2) provision of care above the primary level (ie, interventions not available at a typical local primary care centre) and (3) admission to hospital in-patient care.

    Results: Of 1089 included patients, 260 (24%) visited an emergency department within 7 days. Of these, 209 (80%) were related to the dispatch centre contact, 143 (55%) received interventions above the primary care level and 99 (38%) were admitted to in-patient care. Elderly (65+) patients (OR 1.45, 95% CI 1.05 to 1.98) and patients referred onwards to other healthcare providers (OR 1.58, 95% CI 1.15 to 2.19) had higher likelihoods of visiting an emergency department. Six avoidable patient harms were identified, none of which were captured by existing incident reporting systems, and all of which would have received an ambulance if the decision support system had been strictly adhered to.

    Conclusion: The use of these patient outcomes in the framework of a Global Trigger Tool-based review can identify patient harms missed by incident reporting systems in the context of emergency medical dispatching. Increased compliance with the decision support system has the potential to improve patient safety.

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  • Ciabuschi, Francesco
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies. Univ Bologna, Dept Management, Via Capo Lucca 34, I-40126 Bologna, Italy.;East China Univ Sci & Technol, Sch Business, 130 Meilong Rd, Shanghai 200237, Peoples R China..
    Baraldi, Enrico
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Civil and Industrial Engineering, Industrial Engineering and Management.
    Lindahl, Olof
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    Callegari, Simone
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Supporting innovation against the threat of antibiotic resistance: Exploring the impact of public incentives on firm performance and entrepreneurial orientation2020In: Journal of Business Research, ISSN 0148-2963, E-ISSN 1873-7978, Vol. 112, p. 271-280Article in journal (Refereed)
    Abstract [en]

    Although there is an urgent need to find new antibiotics to fight growing antibiotic resistance, the development of antibiotics is at its lowest level ever. This innovation drought in the antibiotics industry is a challenge for managers, policy makers, and public health authorities. Currently, several strategies to incentivize antibiotic innovation are being considered, but their effects are unknown. Using the theoretical lens of the entrepreneurial orientation framework and Monte Carlo-based simulations on state-of-the-art pharmaceutical industry data, this study found that several incentives can increase the innovativeness of firms in this industry. However, the results show that these effects vary between incentives, between large and small firms, and across different research and development stages. This study analyzed these findings in the light of the entrepreneurial orientation framework and presents implications for theory, policy makers, and managers.

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  • Chen, Hwei-yen
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics.
    Jolly, Cecile
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Human Evolution.
    Bublys, Kasparas
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics.
    Marcu, Daniel
    Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England..
    Immler, Simone
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology. Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England..
    Trade-off between somatic and germline repair in a vertebrate supports the expensive germ line hypothesis2020In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 117, no 16, p. 8973-8979Article in journal (Refereed)
    Abstract [en]

    The disposable soma theory is a central tenet of the biology of aging where germline immortality comes at the cost of an aging soma [T. B. L. Kirkwood, Nature 270, 301-304 (1977); T. B. L. Kirkwood, Proc. R. Soc. Lond. B BioL Sd 205, 531-546 (1979); T. B. L Kirkwood, S. N. Austad, Nature 408, 233-238 (2000)]. Limited resources and a possible trade-off between the repair and maintenance of the germ cells and growth and maintenance of the soma may explain the deterioration of the soma over time. Here we show that germline removal allows accelerated somatic healing under stress. We tested "the expensive germ line" hypothesis by generating germline-free zebrafish Danio rerio and testing the effect of the presence and absence of the germ line on somatic repair under benign and stressful conditions. We exposed male fish to sublethal low-dose ionizing radiation, a genotoxic stress affecting the soma and the germ line, and tested how fast the soma recovered following partial fin ablation. We found that somatic recovery from ablation occurred substantially faster in irradiated germline-free fish than in the control germline-carrying fish where somatic recovery was stunned. The germ line did show signs of postirradiation recovery in germline-carrying fish in several traits related to offspring number and fitness. These results support the theoretical conjecture that germline maintenance is costly and directly trades off with somatic maintenance.

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  • Björk, Albin
    et al.
    Karolinska Inst, Div Rheumatol, Dept Med, Stockholm, Sweden..
    Andersson, Elina Richardsdotter
    Karolinska Inst, Div Rheumatol, Dept Med, Stockholm, Sweden..
    Imgenberg-Kreuz, Juliana
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
    Thorlacius, Gudny Ella
    Karolinska Inst, Div Rheumatol, Dept Med, Stockholm, Sweden..
    Mofors, Johannes
    Karolinska Inst, Div Rheumatol, Dept Med, Stockholm, Sweden..
    Syvänen, Ann-Christine
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Kvarnström, Marika
    Karolinska Inst, Div Rheumatol, Dept Med, Stockholm, Sweden..
    Nordmark, Gunnel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Wahren-Herlenius, Marie
    Karolinska Inst, Div Rheumatol, Dept Med, Stockholm, Sweden..
    Protein and DNA methylation-based scores as surrogate markers for interferon system activation in patients with primary Sjögren's syndrome2020In: RMD Open, E-ISSN 2056-5933, Vol. 6, no 1, article id e000995Article in journal (Refereed)
    Abstract [en]

    Objective: Standard assessment of interferon (IFN) system activity in systemic rheumatic diseases depends on the availability of RNA samples. In this study, we describe and evaluate alternative methods using plasma, serum and DNA samples, exemplified in the IFN-driven disease primary Sjogren's syndrome (pSS).

    Methods: Patients with pSS seropositive or negative for anti-SSA/SSB and controls were included. Protein-based IFN (pIFN) scores were calculated from levels of PD-1, CXCL9 and CXCL10. DNA methylation-based (DNAm) IFN scores were calculated from DNAm levels at RSAD2, IFIT1 and IFI44L. Scores were compared with mRNA-based IFN scores measured by quantitative PCR (qPCR), Nanostring or RNA sequencing (RNAseq).

    Results: mRNA-based IFN scores displayed strong correlations between B cells and monocytes (r=0.93 and 0.95, p<0.0001) and between qPCR and Nanostring measurements (r=0.92 and 0.92, p<0.0001). The pIFN score in plasma and serum was higher in patients compared with controls (p<0.0001) and correlated well with mRNA-based IFN scores (r=0.62-0.79, p<0.0001), as well as with each other (r=0.94, p<0.0001). Concordance of classification as 'high' or 'low' IFN signature between the pIFN score and mRNA-based IFN scores ranged from 79.5% to 88.6%, and the pIFN score was effective at classifying patients and controls (area under the curve, AUC=0.89-0.93, p<0.0001). The DNAm IFN score showed strong correlation to the RNAseq IFN score (r=0.84, p<0.0001) and performed well in classifying patients and controls (AUC=0.96, p<0.0001).

    Conclusions: We describe novel methods of assessing IFN system activity in plasma, serum or DNA samples, which may prove particularly valuable in studies where RNA samples are not available.

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  • Hassell, James M.
    et al.
    Univ Liverpool, Inst Infect & Global Hlth, Neston L7 3EA, England.;Int Livestock Res Inst, Nairobi, Kenya..
    Ward, Melissa J.
    Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh, Midlothian, Scotland.;Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford, England..
    Muloi, Dishon
    Int Livestock Res Inst, Nairobi, Kenya.;Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland..
    Bettridge, Judy M.
    Univ Liverpool, Inst Infect & Global Hlth, Neston L7 3EA, England.;Int Livestock Res Inst, Nairobi, Kenya..
    Robinson, Timothy P.
    Food & Agr Org United Nations, Rome, Italy..
    Kariuki, Sam
    Kenya Govt Med Res Ctr, Ctr Microbiol Res, Nairobi, Kenya..
    Ogendo, Allan
    Int Livestock Res Inst, Nairobi, Kenya..
    Kiiru, John
    Kenya Govt Med Res Ctr, Ctr Microbiol Res, Nairobi, Kenya..
    Imboma, Titus
    Natl Museums Kenya, Nairobi, Kenya..
    Kang'ethe, Erastus K.
    Univ Nairobi, Nairobi, Kenya..
    Öghren, Elin M.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Williams, Nicola J.
    Univ Liverpool, Inst Infect & Global Hlth, Neston L7 3EA, England..
    Begon, Michael
    Univ Liverpool, Inst Integrat Biol, Liverpool, Merseyside, England..
    Woolhouse, Mark E. J.
    Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland..
    Fevre, Eric M.
    Univ Liverpool, Inst Infect & Global Hlth, Neston L7 3EA, England.;Int Livestock Res Inst, Nairobi, Kenya..
    Clinically relevant antimicrobial resistance at the wildlife-livestock-human interface in Nairobi: an epidemiological study2019In: LANCET PLANETARY HEALTH, ISSN 2542-5196, Vol. 3, no 6, p. E259-E269Article in journal (Refereed)
    Abstract [en]

    Background: Antimicrobial resistance is one of the great challenges facing global health security in the modern era. Wildlife, particularly those that use urban environments, are an important but understudied component of epidemiology of antimicrobial resistance. We investigated antimicrobial resistance overlap between sympatric wildlife, humans, livestock, and their shared environment across the developing city of Nairobi, Kenya. We use these data to examine the role of urban wildlife in the spread of clinically relevant antimicrobial resistance.

    Methods: 99 households across Nairobi were randomly selected on the basis of socioeconomic stratification. A detailed survey was administered to household occupants, and samples (n=2102) were collected from the faeces of 75 wildlife species inhabiting household compounds (ie, the household and its perimeter; n=849), 13 livestock species (n=656), and humans (n=333), and from the external environment (n=288). Escherichia coli, our sentinel organism, was cultured and a single isolate from each sample tested for sensitivity to 13 antibiotics. Diversity of antimicrobial resistant phenotypes was compared between urban wildlife, humans, livestock, and the environment, to investigate whether wildlife are a net source for antimicrobial resistance in Nairobi. Generalised linear mixed models were used to determine whether the prevalence of antimicrobial resistant phenotypes and multidrug-resistant E coli carriage in urban wildlife is linked to variation in ecological traits, such as foraging behaviour, and to determine household-level risk factors for sharing of antimicrobial resistance between humans, wildlife, and livestock.

    Findings: E coli were isolated from 485 samples collected from wildlife between Sept 6,2015, and Sept 28, 2016. Wildlife carried a low prevalence of E coli isolates susceptible to all antibiotics tested (45 [9%] of 485 samples) and a high prevalence of clinically relevant multidrug resistance (252 [52%] of 485 samples), which varied between taxa and by foraging traits. Multiple isolates were resistant to one agent from at least seven antimicrobial classes tested for, and a single isolate was resistant to all antibiotics tested for in the study. The phenotypic diversity of antimicrobial-resistant E coli in wildlife was lower than in livestock, humans, and the environment. Within household compounds, statistical models identified two interfaces for exchange of antimicrobial resistance: between both rodents, humans and their rubbish, and seed-eating birds, humans and their rubbish; and between seed-eating birds, cattle, and bovine manure.

    Interpretation: Urban wildlife carry a high burden of clinically relevant antimicrobial-resistant E coli in Nairobi, exhibiting resistance to drugs considered crucial for human medicine by WHO. Identifiable traits of the wildlife contribute to this exposure; however, compared with humans, livestock, and the environment, low phenotypic diversity in wildlife is consistent with the hypothesis that wildlife are a net sink rather than source of clinically relevant resistance. Wildlife that interact closely with humans, livestock, and both human and livestock waste within households, are exposed to more antimicrobial resistant phenotypes, and could therefore act as conduits for the dissemination of clinically relevant antimicrobial resistance to the wider environment. These results provide novel insight into the broader epidemiology of antimicrobial resistance in complex urban environments, characteristic of lower-middle-income countries. 

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  • Sharafati, Ahmad
    et al.
    Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam. Faculty of Civil Engineering, Duy Tan University, Da Nang 550000, Vietnam. Department of Civil Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
    Haghbin, Masoud
    Department of Civil Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
    Aldlemy, Mohammed Suleman
    Department of Mechanical Engineering, Collage of Mechanical Engineering Technology, Benghazi, Libya.
    Mussa, Mohamed H.
    Department of Civil Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Selangor, Malaysia. Department of Civil Engineering, University of Warith Al-Anbiyaa, Karbala 56001, Iraq.
    Al Zand, Ahmed W.
    Department of Civil Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Selangor, Malaysia.
    Ali, Mumtaz
    Deakin-SWU Joint Research Centre on Big Data, School of Information Technology, Deakin University, Victoria 3125, Australia.
    Bhagat, Suraj Kumar
    Faculty of Civil Engineering, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
    Al-Ansari, Nadhir
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Mining and Geotechnical Engineering.
    Yaseen, Zaher Mundher
    Sustainable Developments in Civil Engineering Research Group, Faculty of Civil Engineering, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
    Development of Advanced Computer Aid Model for Shear Strength of Concrete Slender Beam Prediction2020In: Applied Sciences, E-ISSN 2076-3417, Vol. 10, no 11, article id 3811Article in journal (Refereed)
    Abstract [en]

    High-strength concrete (HSC) is highly applicable to the construction of heavy structures. However, shear strength (Ss) determination of HSC is a crucial concern for structure designers and decision makers. The current research proposes the novel models based on the combination of adaptive neuro-fuzzy inference system (ANFIS) with several meta-heuristic optimization algorithms, including ant colony optimizer (ACO), differential evolution (DE), genetic algorithm (GA), and particle swarm optimization (PSO), to predict the Ss of HSC slender beam. The proposed models were constructed using several input combinations incorporating several related dimensional parameters such as effective depth of beam (d), shear span (a), maximum size of aggregate (ag), compressive strength of concrete (fc), and percentage of tension reinforcement (ρ). To assess the impact of the non-homogeneity of the dataset on the prediction result accuracy, two possible modeling scenarios, (i) non-processed (initial) dataset (NP) and (ii) pre-processed dataset (PP), are inspected by several performance indices. The modeling results demonstrated that ANFIS-PSO hybrid model attained the best prediction accuracy over the other models and for the pre-processed input parameters. Several uncertainty analyses were examined (i.e., model, variables, and data), and results indicated predicting the HSC shear strength was more sensitive to the model structure uncertainty than the input parameters.

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  • Hasab, Hashim Ali
    et al.
    Al-Najaf Technical Institute, Department of Architectural Design and Decoration, Al-Furat Al-Awsat Technical University, Najaf 54001, Iraq.
    Dibs, Hayder
    Water Resources Faculty, Department of Hydraulic Structures Engineering, Al-Qasim Green University, Babel 51001, Iraq.
    Dawood, Abdulameer Sulaiman
    Al-Kufa Technical Institute, Al-Furat Al-Awsat Technical University, Kufa 54001, Iraq.
    Hadi, Wurood Hasan
    Remote Sensing Center, University of Kufa, Kufa 54001, Iraq.
    Hussain, Hussain M.
    Remote Sensing Center, University of Kufa, Kufa 54001, Iraq.
    Al-Ansari, Nadhir
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Mining and Geotechnical Engineering.
    Monitoring and Assessment of Salinity and Chemicals in Agricultural Lands by a Remote Sensing Technique and Soil Moisture with Chemical Index Models2020In: Geosciences, ISSN 2076-3263, Vol. 10, no 6, article id 207Article in journal (Refereed)
    Abstract [en]

    Agricultural land in the south of Iraq provides habitat for several types of living creatures. This land has a significant impact on the ecosystem. The agricultural land of Al-Hawizeh marsh covers an area of more than 3500 km2 and is considered an enriched resource to produce several harvests. A total of 74% of this area suffers from a high degree of salinity and chemical pollution, which needs to be remedied. Several human-made activities and post-war-related events have caused radical deterioration in soil quality in the agricultural land. The goal of this research was to integrate mathematical models, remote sensing data, and GIS to provide a powerful tool to predict, assess, monitor, manage, and map the salinity and chemical parameters of iron (Fe), lead (Pb), copper (Cu), chromium (Cr), and zinc (Zn) in the soils of agricultural land in Al-Hawizeh marsh in southern Iraq during the four seasons of 2017. The mathematical model consists of four parts. The first depends on the B6 and B11 bands of Landsat-8, to calculate the soil moisture index (SMI). The second is the salinity equation (SE), which depends on the SMI result to retrieve the salinity values from Landsat-8 images. The third part depends on the B6 and B7 bands of Landsat-8, which calculates the clay chemical index (CCIs). The fourth part is the chemical equation (CE), which depends on the CCI to retrieve the chemical values (Fe, Pb, Cu, Cr, and Zn) from Landsat-8 images. The average salinity concentrations during autumn, summer, spring, and winter were 1175, 1010, 1105, and 1789 mg/dm3, respectively. The average Fe concentrations during autumn, summer, spring and winter were 813, 784, 842, and 1106 mg/dm3, respectively. The average Pb concentrations during autumn, summer, spring, and winter were 4.85, 3.79, 4.74, and 7.2 mg/dm3, respectively. The average Cu concentrations during autumn, summer, spring, and winter were 3.9, 3.1, 4.45, and 7.5 mg/dm3, respectively. The average Cr concentrations during autumn, summer, spring, and winter seasons were 1.28, 0.73, 1.03, and 2.91 mg/dm3, respectively. Finally, the average Zn concentrations during autumn, summer, spring, and winter were 8.25, 6, 7.05, and 12 mg/dm3, respectively. The results show that the concentrations of salinity and chemicals decreased in the summer and increased in the winter. The decision tree (DT) classification depended on the output results for salinity and chemicals for both SE and CE equations. This classification refers to all the parameters simultaneously in one stage. The output of DT classification results can display all the soil quality parameters (salinity, Fe, Pb, Cu, Cr, and Zn) in one image. This approach was repeated for each season in this study. In conclusion, the developed systematic and generic approach may constitute a basis for determining soil quality parameters in agricultural land worldwide.

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  • Wylde, Zachariah
    et al.
    Univ New South Wales, Evolut & Ecol Res Ctr, Sch Biol Earth & Environm Sci, Sydney, NSW, Australia..
    Spagopoulou, Foteini
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
    Hooper, Amy K.
    Univ New South Wales, Evolut & Ecol Res Ctr, Sch Biol Earth & Environm Sci, Sydney, NSW, Australia..
    Maklakov, Alexei
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology. Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich, Norfolk, England..
    Bonduriansky, Russell
    Univ New South Wales, Evolut & Ecol Res Ctr, Sch Biol Earth & Environm Sci, Sydney, NSW, Australia..
    Parental breeding age effects on descendants' longevity interact over 2 generations in matrilines and patrilines2019In: PLoS biology, ISSN 1544-9173, E-ISSN 1545-7885, Vol. 17, no 11, article id e3000556Article in journal (Refereed)
    Abstract [en]

    Individuals within populations vary enormously in mortality risk and longevity, but the causes of this variation remain poorly understood. A potentially important and phylogenetically widespread source of such variation is maternal age at breeding, which typically has negative effects on offspring longevity. Here, we show that paternal age can affect offspring longevity as strongly as maternal age does and that breeding age effects can interact over 2 generations in both matrilines and patrilines. We manipulated maternal and paternal ages at breeding over 2 generations in the neriid fly Telostylinus angusticollis. To determine whether breeding age effects can be modulated by the environment, we also manipulated larval diet and male competitive environment in the first generation. We found separate and interactive effects of parental and grand-parental ages at breeding on descendants' mortality rate and life span in both matrilines and patrilines. These breeding age effects were not modulated by grand-parental larval diet quality or competitive environment. Our findings suggest that variation in maternal and paternal ages at breeding could contribute substantially to intrapopulation variation in mortality and longevity.

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  • Good collections management: Guidance for handling human remains in museum collections2020Report (Other academic)
    Abstract [en]

    This document is aimed at museums in Sweden with collections that include human remains. The purpose of this document is to support museums internally within the organisation and externally in contact with the surrounding community. It has been compiled for museums of all types, but diferent museums may encounter diferent issues depending on the form of organisation or the size or types of collections. This is why every museum should set up its own policy documents and procedures suitable for its own museological needs and conditions. Other organisations with museum collections may also fnd this document useful.

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  • Good collections management: Guidance for managing the return of cultural objects2020Report (Other academic)
    Abstract [en]

    This document has been produced to assist Swedish museums with issues relating to the return of objects. Other organisations with museum collections may also fnd this information useful.

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  • Lindner, Philip
    et al.
    Stockholm Univ, Dept Psychol, Stockholm, Sweden;Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden;Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden.
    Miloff, Alexander
    Stockholm Univ, Dept Psychol, Stockholm, Sweden.
    Bergman, Camilla
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Andersson, Gerhard
    Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden;Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden;Linkoping Univ, Dept Behav Sci & Learning, Linkoping, Sweden.
    Hamilton, William
    Mimerse AB, Stockholm, Sweden.
    Carlbring, Per
    Stockholm Univ, Dept Psychol, Stockholm, Sweden.
    Gamified, Automated Virtual Reality Exposure Therapy for Fear of Spiders: A Single-Subject Trial Under Simulated Real-World Conditions2020In: Frontiers in Psychiatry, ISSN 1664-0640, E-ISSN 1664-0640, Vol. 11, article id 116Article in journal (Refereed)
    Abstract [en]

    Background: Virtual Reality exposure therapy (VRET) is an evidence-based treatment of phobias and recent research suggests that this applies also to self-contained, automated interventions requiring no therapist guidance. With the advent and growing adoption of consumer VR technology, automated VR intervention have the potential to close the considerable treatment gap for specific phobias through dissemination as consumer applications, self-help at clinics, or as blended treatment. There is however a lack of translational effectiveness studies on VRET treatment effects under real-world conditions.

    Methods: We conducted a single-arm (n = 25), single-subject study of automated, gamified VRET for fear of spiders, under simulated real-world conditions. After setup and reading instructions, participants completed the automated, single-session treatment by themselves. Self-rated fear of spiders and quality of life served as outcome measures, measured twice before, and one and two weeks after treatment, and at a six-month follow-up. Session characteristics and user experience measures were collected at the end of the session.

    Results: Mixed-effects modeling revealed a significant and large (d = 1.26) effect of treatment-onset on phobia symptoms (p < .001), and a small (d = 0.49) effect on quality of life (p = .025). Results were maintained at a six-month follow-up (p > .053). The intervention was tolerable and practical. There were no significant correlations between any user experience measure and decrease in phobia symptoms (p > .209).

    Conclusions: An automated VRET intervention for fear of spiders showed equivalent effects on phobia symptoms under effectiveness conditions as previously reported under efficacy conditions. These results suggest that automated VRET applications are promising self-help treatments also when provided under real-world conditions.

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  • Kulturarvets ekonomiska påverkan: En kartläggning av samhällsekonomiska effekter genom indikatorer2020Report (Other academic)
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  • Carlsson, Tommy
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Sophiahemmet Univ Coll, Stockholm, Sweden.;Swedish Red Cross Univ Coll, Huddinge, Sweden..
    Ulfsdottir, Hanna
    Sophiahemmet Univ Coll, Stockholm, Sweden.;Karolinska Univ Hosp, PO Pregnancy & Birth, Stockholm, Sweden..
    Waterbirth in low-risk pregnancy: An exploration of women's experiences2020In: Journal of Advanced Nursing, ISSN 0309-2402, E-ISSN 1365-2648, Vol. 76, no 5, p. 1221-1231Article in journal (Refereed)
    Abstract [en]

    Aims To explore retrospective descriptions about benefits, negative experiences and preparatory information related to waterbirths. Design A qualitative study. Methods Women who gave birth in water with healthy pregnancies and low-risk births were consecutively recruited between December 2015-October 2018 from two birthing units in Sweden. All who gave birth in water during the recruitment period were included (N = 155) and 111 responded to the survey. Women were emailed a web-based survey six weeks postpartum. Open-ended questions were analysed with qualitative content analysis. Results Two themes were identified related to benefits: (a) physical benefits: the water eases labour progression while offering buoyancy and pain relief; and (b) psychological benefits: improved relaxation and control in a demedicalized and safe setting. Two themes were identified related to negative experiences: (a) equipment-related issues due to the construction of the tub and issues related to being immersed in water; and (b) fears and worries related to waterbirth. In regard to preparatory information, respondents reported a lack of general and specific information related to waterbirths, even after they contacted birthing units to ask questions. Supplemental web-based information was sought, but the trustworthiness of these sources was questioned and a need for trustworthy web-based information was articulated. Conclusion Women who give birth in water experience physical and psychological benefits, but need better equipment and sufficient information. There is room for improvement with regard to prenatal and intrapartum care of women who give birth in water. Impact Judging from women's recounts, midwives and nurses should continue advocating waterbirth in low-risk pregnancies. The lack of adequate equipment in Swedish birthing units articulated by women challenge current routines and resources. The findings illustrate unfulfilled needs for preparatory information about waterbirth, further strengthening that midwives should discuss the possibility of waterbirth when meeting expectant parents in the antenatal setting.

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  • Public defence: 2020-06-09 09:30 C312, Sundsvall
    Bakar, Muhammad Abu
    Mid Sweden University, Faculty of Science, Technology and Media, Department of Electronics Design.
    Wide Range Isolated Power Converters2020Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Power electronics technology is rapidly growing in most industrialapplications. There is an increasing demand for efficient and low profilepower converters in the industry like automotive, power grids, renewableenergy systems, electric rail systems, home appliances, and informationtechnology. In some applications, there is an increasing demand for powerconverters showing a stable performance over a wide variation in inputvoltage, whereas in others the demand is for converters showing a stableperformance over a wide variation of output voltage. In this regard, not somuch work has been done to combine both requirements into one solution;this is the primary focus of the dissertation. It presents a unique solution tothe industry, which addresses both requirements. The technique can beapplied in a one size fits all solution which not only extends the range of theline voltage and the output voltage but also provides the flexibility to adjustthe required set of line/output voltage. The variation in line voltage severelydegrades the performance of power converters because of the extendedfreewheeling interval, more circulating current, narrow range of zero voltageswitching and increased EMI. To overcome this, the converter consists of tworeconfigurable modes on the input side that can be configured following thevariation in line voltage to maintain a stable performance. In addition, itproposes three reconfigurable steps for the output voltage, which can be usedto adjust the output voltage from base level X to 2X and 4X in discrete stepsand/or from X - 4X volt while showing stable performance. This makes theproposal a 2x3 reconfigurable modes power converter, which means that thegain of the proposed converter can be raised to 4 or 8. Furthermore, theflexibility in the reconfigurable structure simplifies the implementation of theproposed single solution in a range of applications. Each concept proposed inthe thesis is verified analytically, experimentally and modelling it into aSPICE simulation. Then the whole concept is confined into a single entity,which is applied in an example application of a phase shifted full bridgeconverter. The full converter is characterized for input voltage 100-400Vdc, theoutput voltage 24-96Vdc, and up to the load power of 1kW.

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  • Koloseni, David
    et al.
    Department of Mathematics, University of Dar es Salaam, Tanzania.
    Helldin, Tove
    University of Skövde, School of Informatics. University of Skövde, Informatics Research Environment.
    Torra, Vicenç
    University of Skövde, School of Informatics. University of Skövde, Informatics Research Environment. Hamilton Institute, Maynooth University, Maynooth, Ireland.
    AHP-Like Matrices and Structures: Absolute and Relative Preferences2020In: Mathematics, E-ISSN 2227-7390, Vol. 8, no 5, article id 813Article in journal (Refereed)
    Abstract [en]

    Aggregation functions are extensively used in decision making processes to combine available information. Arithmetic mean and weighted mean are some of the most used ones. In order to use a weighted mean, we need to define its weights. The Analytical Hierarchy Process (AHP) is a well known technique used to obtain weights based on interviews with experts. From the interviews we define a matrix of pairwise comparisons of the importance of the weights. We call these AHP-like matrices absolute preferences of weights. We propose another type of matrix that we call a relative preference matrix. We define this matrix with the same goal—to find the weights for weighted aggregators. We discuss how it can be used for eliciting the weights for the weighted mean and define a similar approach for the Choquet integral.

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  • Josefsson, Andreas
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Sahlgrenska Canc Ctr, Dept Urol, S-40530 Gothenburg, Sweden;Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, S-90187 Umea, Sweden;Umea Univ, Wallenberg Ctr Mol Med, S-90187 Umea, Sweden.
    Larsson, Karin
    Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Sahlgrenska Canc Ctr, Dept Urol, S-40530 Gothenburg, Sweden.
    Freyhult, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Damber, Jan-Erik
    Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Sahlgrenska Canc Ctr, Dept Urol, S-40530 Gothenburg, Sweden.
    Welén, Karin
    Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Sahlgrenska Canc Ctr, Dept Urol, S-40530 Gothenburg, Sweden.
    Gene Expression Alterations during Development of Castration-Resistant Prostate Cancer Are Detected in Circulating Tumor Cells2020In: Cancers, ISSN 2072-6694, Vol. 12, no 1, article id 39Article in journal (Refereed)
    Abstract [en]

    Development of castration-resistant prostate cancer (CRPC) is associated with alterations in gene expression involved in steroidogenesis and androgen signaling. This study investigates whether gene expression changes related to CRPC development can be identified in circulating tumor cells (CTCs). Gene expression in paired CTC samples from 29 patients, before androgen deprivation therapy (ADT) and at CRPC relapse, was compared using a panel including 47 genes related to prostate cancer progression on a qPCR platform. Fourteen genes displayed significantly changed gene expression in CTCs at CRPC relapse compared to before start of ADT. The genes with increased expression at CRPC relapse were related to steroidogenesis, AR-signaling, and anti-apoptosis. In contrast, expression of prostate markers was downregulated at CRPC. We also show that midkine (MDK) expression in CTCs from metastatic hormone-sensitive prostate cancer (mHSPC) was associated to short cancer-specific survival (CSS). In conclusion, this study shows that gene expression patterns in CTCs reflect the development of CRPC, and that MDK expression levels in CTCs are prognostic for cancer-specific survival in mHSPC. This study emphasizes the role of CTCs in exploring mechanisms of therapy resistance, as well as a promising biomarker for prognostic and treatment-predictive purposes in advanced mHSPC.

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  • Carvalho, Francisca C.
    et al.
    Bergen Univ, Dept Biol Sci, Bergen, Norway;Bergen Univ, KG Jebsen Ctr Deep Sea Res, Bergen, Norway.
    Cárdenas, Paco
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi.
    Rios, Pilar
    Inst Espanol Oceanog, Ctr Oceanog Gijon, Gijon, Spain;Univ Alcala de Henares, Dept Zool & Antropol Fis, Madrid, Spain.
    Cristobo, Javier
    Inst Espanol Oceanog, Ctr Oceanog Gijon, Gijon, Spain;Univ Alcala de Henares, Dept Zool & Antropol Fis, Madrid, Spain.
    Rapp, Hans Tore
    Bergen Univ, Dept Biol Sci, Bergen, Norway;Bergen Univ, KG Jebsen Ctr Deep Sea Res, Bergen, Norway.
    Xavier, Joana R.
    Bergen Univ, Dept Biol Sci, Bergen, Norway;Bergen Univ, KG Jebsen Ctr Deep Sea Res, Bergen, Norway;Univ Porto, CIIMAR Interdisciplinary Ctr Marine & Environm Re, Matosinhos, Portugal.
    Rock sponges (lithistid Demospongiae) of the Northeast Atlantic seamounts, with description of ten new species2020In: PeerJ, ISSN 2167-8359, E-ISSN 2167-8359, Vol. 8, article id e8703Article in journal (Refereed)
    Abstract [en]

    Background: Lithistid demosponges, also known as rock sponges, are a polyphyletic group of sponges which are widely distributed. In the Northeast Atlantic (NEA), 17 species are known and the current knowledge on their distribution is mainly restricted to the Macaronesian islands. In the Mediterranean Sea, 14 species are recorded and generally found in marine caves.

    Methods: Lithistids were sampled in nine NEA seamounts during the scientific expeditions Seamount 1 (1987) and Seamount 2 (1993) organized by the MNHN of Paris. Collected specimens were identified through the analyses of external and internal morphological characters using light and scanning electron microscopy, and compared with material from various museum collections as well as literature records.

    Results: A total of 68 specimens were analysed and attributed to 17 species across two orders, seven families, and seven genera, representing new records of distribution. Ten of these species are new to science, viz. Neoschrammeniella inaequalis sp. nov., N. piserai sp. nov., N. pomponiae sp. nov., Discodermia arbor sp. nov., D. kellyae sp. nov., Macandrewia schusterae sp. nov., M. minima sp. nov., Exsuperantia levii sp. nov., Leiodermatium tuba sp. nov. and Siphonidium elongatus sp. nov., and are here described and illustrated. New bathymetric records were also found for D. ramifera, D. verrucosa and M. robusta. The Meteor seamount group has a higher species richness (15 species) compared to the Lusitanian seamount group (six species). The majority of the species had their distribution restricted to one seamount, and ten are only known from a single locality, but this can be a result of sample bias.

    Discussion: The number of species shared between the seamounts and the Macaronesian islands is very reduced. The same pattern repeats between the NEA and Mediterranean Sea. This study demonstrates that NEA seamounts are ecosystems with a higher diversity of lithistids than previously thought, increasing the number of lithistids known to occur in the NEA and Mediterranean Sea from 26 to 36 species.

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  • Westphal, Florian
    et al.
    Blekinge Institute of Technology, Faculty of Computing, Department of Computer Science.
    Grahn, Håkan
    Blekinge Institute of Technology, Faculty of Computing, Department of Computer Science.
    Lavesson, Niklas
    Jönköpings universitet.
    Representative Image Selection for Data Efficient Word Spotting2020In: 14th IAPR International Workshop on Document Analysis Systems (DAS), Springer, 2020Conference paper (Refereed)
    Abstract [en]

    This paper compares three different word image representations as base for label free sample selection for word spotting in historical handwritten documents. These representations are a temporal pyramid representation based on pixel counts, a graph based representation, and a pyramidal histogram of characters (PHOC) representation predicted by a PHOCNet trained on synthetic data. We show that the PHOC representation can help to reduce the amount of required training samples by up to 69% depending on the dataset, if it is learned iteratively in an active learning like fashion. While this works for larger datasets containing about 1 700 images, for smaller datasets with 100 images, we find that the temporal pyramid and the graph representation perform better.

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  • Toia, Marco
    Malmö University, Faculty of Odontology.
    On Clinical and Mechanical Aspects in Implant Supported Screw Retained Multi-unit CAD-CAM Metal Framework2020Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Conventionally casted frameworks have been considered the preferredsolutions for complete and partial restorations since the beginningof implantology. However, following technological development, thecomputer aided design/computer aided manufacturing (CAD-CAM)with milling the frameworks has been introduced as an alternativeoption with the potential of minimising inaccuracies, reducing theoperator dependence and offering a homogeneous structure with highmechanical properties. The CAD-CAM multi-unit reconstructionvaries with fixation type, implant framework connection, andprostheses material. However, the materials developed for theuse of CAD-CAM, may have different technical and biologicalcomplications with time.The present thesis aims to provide insights into the risk ofcomplications in screw-retained multi-unit frameworks manufacturedusing the CAD-CAM technique. An in vitro test (Study I) was performed to assess the effectsof misfit at implant-level FPDs and supporting bone levels on thegeneration of implant cracks. Three clinical studies were conducted:in Study II, partially edentulous patients were rehabilitated with eitheran abutment or implant level multi-unit Cobalt-Chromium metalceramicframework; in Study III, patients, edentulous in the maxilla,were treated with either four or six implants and rehabilitated witha fixed titanium metal-acrylic framework; in Study IV edentulouspatients were treated with removable overdentures retained bytitanium milled bars. In Study III and IV, Oral Health Related Qualityof Life was evaluated.The marginal bone level change was clinically not significantregardless of fixation type (Study II), retention (Study III-IV), andmaterial used (Study II-III-IV). No framework complications wereregistered. Patients reported a high level of satisfaction after thetreatment (Study III-IV).

    Based on the studies included in this thesis, the followingconclusions can be made: (i) the risk of implant cracks in screwretainedImplant Level (IL) Fixed Partial Denture (FPD) is low, evenwith a misfit; (ii) according to the 1-year data presented in Study II,abutment level (AL) retention is recommended for FPDs; (iii) the costeffectivefor a maxillary Fixed Complete Denture (FCD) supported byfour implants can be considered predictable and comparable to siximplants; (iv) implant-supported FCDs and Implant supported Over-Dentures (IOD) are associated with high rates of patient satisfaction,related to aesthetics and mastication function mainly resulting fromthe high stability of the prostheses; (v) the technical and biologicalcomplications reported in FPDs, FCDs and IODs were limited.However, a considerable percentage of prosthetic fractures andchippings were reported for FCDs at 1-year and 3-year follow-ups.Clinicians have to be aware that additional visits may be required formaintaining the prostheses.

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  • Nabil, Nehal M.
    et al.
    Agr Res Ctr, Anim Hlth Res Inst, Reference Lab Vet Qual Control Poultry Prod, Giza 12618, Egypt.
    Erfan, Ahmed M.
    Agr Res Ctr, Anim Hlth Res Inst, Reference Lab Vet Qual Control Poultry Prod, Giza 12618, Egypt.
    Tawakol, Maram M.
    Agr Res Ctr, Anim Hlth Res Inst, Reference Lab Vet Qual Control Poultry Prod, Giza 12618, Egypt.
    Haggag, Naglaa M.
    Agr Res Ctr, Anim Hlth Res Inst, Reference Lab Vet Qual Control Poultry Prod, Giza 12618, Egypt.
    Naguib, Mahmoud
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Agr Res Ctr, Anim Hlth Res Inst, Reference Lab Vet Qual Control Poultry Prod, Giza 12618, Egypt.
    Samy, Ahmed
    Agr Res Ctr, Anim Hlth Res Inst, Reference Lab Vet Qual Control Poultry Prod, Giza 12618, Egypt;Pirbright Inst, Immunogenet, Woking GU24 0NF, Surrey, England.
    Wild Birds in Live Birds Markets: Potential Reservoirs of Enzootic Avian Influenza Viruses and Antimicrobial Resistant Enterobacteriaceae in Northern Egypt2020In: Pathogens, ISSN 2076-0817, Vol. 9, no 3, article id 196Article in journal (Refereed)
    Abstract [en]

    Wild migratory birds are often implicated in the introduction, maintenance, and global dissemination of different pathogens, such as influenza A viruses (IAV) and antimicrobial-resistant (AMR) bacteria. Trapping of migratory birds during their resting periods at the northern coast of Egypt is a common and ancient practice performed mainly for selling in live bird markets (LBM). In the present study, samples were collected from 148 wild birds, representing 14 species, which were being offered for sale in LBM. All birds were tested for the presence of AIV and enterobacteriaceae. Ten samples collected from Northern Shoveler birds (Spatula clypeata) were positive for IAV and PCR sub-typing and pan HA/NA sequencing assays detected H5N8, H9N2, and H6N2 viruses in four, four, and one birds, respectively. Sequencing of the full haemagglutinin (HA) gene revealed a high similarity with currently circulating IAV in Egypt. From all the birds, E. coli was recovered from 37.2% and Salmonella from 20.2%, with 66-96% and 23-43% isolates being resistant to at least one of seven selected critically important antimicrobials (CIA), respectively. The presence of enzootic IAV and the wide prevalence of AMR enterobacteriaceae in wild birds highlight the potential role of LBM in the spread of different pathogens from and to wild birds. Continued surveillance of both AIV and antimicrobial-resistant enterobacteriaceae in wild birds' habitats is urgently needed.

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  • ÅRSRAPPORT 2019: Institutionen för folkhälsa och klinisk medicin2020Report (Other academic)
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  • Dai, Wenhong
    et al.
    College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing 210098, China. State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Nanjing 210098, China.
    Ding, Wei
    College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing 210098, China.
    Lu, Chuanteng
    State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Nanjing 210098, China. Nanjing Hydraulic Research Institute, Nanjing 210029, China.
    Luo, Xiaofeng
    State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Nanjing 210098, China. Nanjing Hydraulic Research Institute, Nanjing 210029, China.
    Xie, Qiancheng
    Luleå University of Technology, Department of Engineering Sciences and Mathematics, Fluid and Experimental Mechanics.
    Field Investigations of Underwater Mounds Formed by Hopper Dredge Discharges in a Coastal Environment2020In: Journal of Marine Science and Engineering, E-ISSN 2077-1312, Vol. 8, no 6, article id 395Article in journal (Refereed)
    Abstract [en]

    In a coastal environment, this paper investigated the formation process and the cumulative shape of subaqueous mounds formed by hopper dredged discharges. Hydrological observations and field tests were performed to examine the flow features and ultimately generated morphology characteristics. A high-precision digital elevation model (DEM) was established by multi-beam depth sweeping (MBDS) in the experiment. Particular attention was paid to the formation of the mounds, the three-dimensional shape and the influence factors. The field measurements showed that the mounds were roughly symmetrical in space, and the tidal current, though of weak strength, played a certain role in shaping the profiles. Cone and volcanic cone mound tops were observed, featuring the main top shapes. The height and covered area of the mounds were proportional to the amount of dumped sediment, and they were also affected a lot by the water depth. The results of superimposed tests showed that the second placement over the existing mound resulted in a similar overall shape, but there was pronounced movement around the mound; additional discharged volumes at the same location mainly increased the mound height. The field tests provided a reference for understanding the sediment dumping in other similar coastal areas.

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  • Johannessen, Ane
    et al.
    Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
    Lonnebotn, Marianne
    Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
    Calciano, Lucia
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Benediktsdottir, Bryndis
    Univ Iceland, Fac Med, Reykjavik, Iceland;Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland.
    Bertelsen, Randi Jacobsen
    Univ Bergen, Dept Clin Sci, Bergen, Norway.
    Bråbäck, Lennart
    Dept Publ Hlth & Clin Med, Occupat & Environm Med, Umeå, Sweden.
    Dharmage, Shyamali
    Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia.
    Franklin, Karl A.
    Umeå Univ, Surg, Dept Surg & Perioperat Sci, Umeå, Sweden.
    Gislason, Thorarinn
    Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland.
    Holm, Mathias
    Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Jarvis, Deborah
    Imperial Coll, Natl Heart & Lung Inst, Fac Med, London, England.
    Jõgi, Rain
    Tartu Univ Hosp, Lung Clin, Tartu, Estonia.
    Kim, Jeong-Lim
    Univ Gothenburg, Sahlgrenska Acad, Dept Publ Hlth & Community Med, Occupat & Environm Med, Gothenburg, Sweden.
    Kirkeleit, Jorunn
    Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5021 Bergen, Norway.
    Lodge, Caroline
    Univ Melbourne, Dept Populat Hlth, Melbourne, Vic, Australia.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Martinez-Moratalla, Jesus
    CHUA, Serv Neurol, Serv Salud Castilla La Mancha SESCAM, Albacete, Spain.
    Nilsen, Roy Miodini
    Bergen Univ Coll, Dept Nursing, Bergen, Norway.
    Pereira-Vega, Antonio
    Hosp Juan Ramon Jimenez, Pneumol Sect, Huelva, Spain.
    Real, Francisco Gomez
    Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynecol, Bergen, Norway.
    Schlunssen, Vivi
    Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.
    Accordini, Simone
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Svanes, Cecilie
    Haukeland Hosp, Dept Occupat Med, Bergen, Norway;Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway.
    Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?2020In: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 145, no 3, p. 791-799.e4Article in journal (Refereed)
    Abstract [en]

    Background: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation.

    Objective: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring.

    Methods: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status.

    Results: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found.

    Conclusion: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health.

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  • Magnusson, Bertil
    et al.
    RISE Research Institutes of Sweden, Materials and Production, Chemistry, Biomaterials and Textiles.
    Örnemark, Ulf
    Emendo dokumentgranskning, Sweden.
    Metodvalidering : Handbok för laboratoriet: utgåva 42020Report (Other academic)
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  • El Ansari, Walid
    et al.
    University of Skövde, School of Health Sciences. University of Skövde, Digital Health Research (DHEAR). Department of Surgery, Hamad General Hospital, Hamad Medical Corporation, Qatar / College of Medicine, Qatar University, Qatar.
    El-Ansari, Kareem
    Hamad General Hospital, Hamad Medical Corporation, Qatar.
    Missing Something? Comparisons of Effectiveness and Outcomes of Bariatric Surgery Procedures and Their Preferred Reporting: Refining the Evidence Base2020In: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428Article, review/survey (Refereed)
    Abstract [en]

    Comparisons of effectiveness of bariatric surgery (BS) procedures encompass weight loss, metabolic/clinical outcomes, and improvements or worsening of comorbidities. Post-operative physical activity (PA) and diet influence such outcomes but are frequently not included in comparisons of effectiveness. We assessed the value and necessity of including post-operative PA/diet data when comparing effectiveness of BS. Including post-operative PA/diet data has significant benefits for BS and patients. The paper proposes an explicit preferred reporting system (Preferred REporting of post-operative PHYsical activity and Diet data in comparisons of BS effectiveness: PRE-PHYD Bariatric). Including post-operative PA/diet data could result in more accurate appraisals of effectiveness of BS procedures. This could translate into better 'individualized' BS by achieving a better 'fit' between patient and procedure.

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  • Andersson Ersman, Peter
    et al.
    RISE Research Institutes of Sweden, Digital Systems.
    Zabihipour, Marzieh
    Linköping University, Sweden.
    Tu, Deyu
    Linköping University, Sweden.
    Lassnig, Roman
    RISE Research Institutes of Sweden, Digital Systems.
    Strandberg, Jan
    RISE Research Institutes of Sweden, Digital Systems, Smart Hardware.
    Åhlin, Jessica
    RISE Research Institutes of Sweden, Digital Systems, Smart Hardware.
    Nilsson, Marie
    RISE Research Institutes of Sweden, Digital Systems, Smart Hardware.
    Westerberg, David
    RISE Research Institutes of Sweden, Digital Systems.
    Gustafsson, Göran
    RISE Research Institutes of Sweden, Digital Systems.
    Berggren, Magnus
    Linköping University, Sweden.
    Forchheimer, Robert
    Linköping University, Sweden.
    Fabiano, Simone
    Linköping University, Sweden.
    Monolithic integration of display driver circuits and displays manufactured by screen printing2020In: Flexible and Printed Electronics, ISSN 2058-8585, Vol. 5, no 2, article id 024001Article in journal (Refereed)
    Abstract [en]

    Here, we report all-screen printed display driver circuits, based on organic electrochemical transistors (OECTs), and their monolithic integration with organic electrochromic displays (OECDs). Both OECTs and OECDs operate at low voltages and have similar device architectures, and, notably, they rely on the very same electroactive material as well as on the same electrochemical switching mechanism. This then allows us to manufacture OECT-OECD circuits in a concurrent manufacturing process entirely based on screen printing methods. By taking advantage of the high current throughput capability of OECTs, we further demonstrate their ability to control the light emission in traditional light-emitting diodes (LEDs), where the actual LED addressing is achieved by an OECT-based decoder circuit. The possibility to monolithically integrate all-screen printed OECTs and OECDs on flexible plastic foils paves the way for distributed smart sensor labels and similar Internet of Things applications.

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  • Colom i Bernadich, Miquel
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Pérez de los Heros, Carlos
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Limits on Kaluza-Klein dark matter annihilation in the Sun from recent IceCube results2020In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 80, no 2, article id 129Article in journal (Refereed)
    Abstract [en]

    We interpret recent IceCube results on searches for dark matter accumulated in the Sun in terms of the lightest Kaluza-Klein excitation (assumed here to be the Kaluza-Klein photon, B1), obtaining improved limits on the annihilation rate in the Sun, the resulting neutrino flux at the Earth and on the B1-proton cross-sections, for B1 masses in the range 30-3000 GeV. These results improve previous results from IceCube in its 22-string configuration by up to an order of magnitude, depending on mass, but also extend the results to B1masses as low as 30 GeV.

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  • Saxena, Vidit
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Information Science and Engineering.
    Gonzalez, Joseph E.
    University of California, Berkeley.
    Jaldén, Joakim
    KTH, Superseded Departments (pre-2005), Signals, Sensors and Systems. KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Information Science and Engineering.
    Thompson Sampling for Linearly Constrained Bandits2020Conference paper (Refereed)
    Abstract [en]

    We address multi-armed bandits (MAB) where the objective is to maximize the cumulative reward under a probabilistic linear constraint. For a few real-world instances of this problem, constrained extensions of the well-known Thompson Sampling (TS) heuristic have recently been proposed. However, finite-time analysis of constrained TS is challenging; as a result, only O(sqrt{T}) bounds on the cumulative reward loss (i.e., the regret) are available. In this paper, we describe LinConTS, a TS-based algorithm for bandits that place a linear constraint on the probability of earning a reward in every round. We show that for LinConTS, the regret as well as the cumulative constraint violations are upper bounded by O(log{T}) for the suboptimal arms. We develop a proof technique that relies on careful analysis of the dual problem and combine it with recent theoretical work on unconstrained TS. Through numerical experiments on two real-world datasets, we demonstrate that LinConTS outperforms an asymptotically optimal upper confidence bound (UCB) scheme in terms of simultaneously minimizing the regret and the violation.

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  • Vishina, Alena
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Vekilova, Olga Yu.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Bjorkman, Torbjorn
    Abo Akad Univ, Dept Nat Sci, FI-20500 Turku, Finland.
    Bergman, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Herper, Heike C.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Eriksson, Olle
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. School of Science and Technology, Örebro University, Örebro, Sweden.
    High-throughput and data-mining approach to predict new rare-earth free permanent magnets2020In: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 101, no 9, article id 094407Article in journal (Refereed)
    Abstract [en]

    We present an application of a high-throughput search of new rare-earth free permanent magnets focusing on 3d-5d transition metal compounds. The search involved a part of the Inorganic Crystal Structure Database, together with tailored search criteria and electronic structure calculations of magnetic properties. Our results suggest that it is possible to find candidates for rare-earth free permanent magnets using a data-mining/datafiltering approach. The most promising candidates identified here are Pt2FeNi, Pt2FeCu, and W2FeB2. We suggest these materials to be a good platform for further investigations in the search of novel rare-earth free permanent magnets.

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  • ATK årsrapport 20192020Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    Automatisk trafiksäkerhetskontroll (ATK) är ett system för automatisk hastighets- övervakning med kameror. Målet med trafiksäkerhetskameror är att sänka medelhastigheten på våra mest olycksdrabbade vägar och på det sättet minska antalet döda och allvarligt skadade. Systemet förvaltas av Trafikverket och Polismyndigheten.

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  • Deyev, Sergey M.
    et al.
    Russian Acad Sci, Mol Immunol Lab, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow, Russia;Res Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Tomsk, Russia;Sechenov Univ, Ctr Biomed Engn, Moscow, Russia.
    Vorobyeva, Anzhelika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. Res Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Tomsk, Russia.
    Schulga, Alexey
    Russian Acad Sci, Mol Immunol Lab, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow, Russia;Res Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Tomsk, Russia.
    Abouzayed, Ayman
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics.
    Günther, Tyran
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Garousi, Javad
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Konovalova, Elena
    Russian Acad Sci, Mol Immunol Lab, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow, Russia.
    Ding, Haozhong
    KTH Royal Inst Technol, Dept Prot Sci, Stockholm, Sweden.
    Graslund, Torbjorn
    KTH Royal Inst Technol, Dept Prot Sci, Stockholm, Sweden.
    Orlova, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics. Uppsala University, Science for Life Laboratory, SciLifeLab. Res Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Tomsk, Russia.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. Res Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Tomsk, Russia.
    Effect of a radiolabel biochemical nature on tumor-targeting properties of EpCAM-binding engineered scaffold protein DARPin Ec12020In: International Journal of Biological Macromolecules, ISSN 0141-8130, E-ISSN 1879-0003, Vol. 145, p. 216-225Article in journal (Refereed)
    Abstract [en]

    Radionuclide-based imaging of molecular therapeutic targets might facilitate stratifying patients for specific biotherapeutics. New type of imaging probes, based on designed ankyrin repeat proteins (DARPins), have demonstrated excellent contrast of imaging of human epidermal growth factor type 2 (HER2) expression in preclinical models. We hypothesized that labeling approaches, which result in lipophilic radiometabolites (non-residualizing labels), would provide the best imaging contrast for DARPins that internalize slowly after binding to cancer cells. The hypothesis was tested using DARPin Ec1 that binds to epithelial cell adhesion molecule (EpCAM). EpCAM is a promising therapeutic target. Ec1 was labeled with I-125 using two methods to obtain the non-residualizing labels, while residualizing labels were obtained by labeling it with Tc-99m. All labeled Ec1 variants preserved target specificity and picomolar binding affinity to EpCAM-expressing pancreatic adenocarcinoma BxPC-3 cells. In murine models, all the variants provided similar tumor uptake. However, I-125-PIB-H-6-Ec1 had noticeably lower retention in normal tissues, which provided appreciably higher tumor-to-organ ratios. Furthermore, I-125-PIB-H-6-Ec1 demonstrated the highest imaging contrast in preclinical models than any other EpCAM-imaging agent tested so far. In conclusion, DARPin Ec1 in combination with a non-residualizing label is a promising probe for imaging EpCAM expression a few hours after injection.

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  • Palladino, Nicoletta
    et al.
    Swedish National Heritage Board, Sweden.
    Hacke, Marei
    Swedish National Heritage Board, Sweden.
    Poggi, Giovanna
    University of Florence, Italy.
    Nechyporchuk, Oleksandr
    RISE Research Institutes of Sweden, Materials and Production, Chemistry, Biomaterials and Textiles. Chalmers University of Technology, Sweden.
    Kolman, Krzysztof
    Chalmers University of Technology, Sweden; Nouryon, Sweden.
    Xu, Qingmeng
    University of Florence, Italy.
    Persson, Michael E.
    Chalmers University of Technology, Sweden; Nouryon, Sweden.
    Giorgi, Rodorico
    University of Florence, Italy.
    Holmberg, Krister
    Chalmers University of Technology, Sweden.
    Baglioni, Piero
    University of Florence, Italy.
    Bordes, Romain
    Chalmers University of Technology, Sweden.
    Nanomaterials for combined stabilisation and deacidification of cellulosic materials: the case of iron-tannate dyed cotton2020In: Nanomaterials, ISSN 2079-4991, Vol. 10, no 5, article id 900Article in journal (Refereed)
    Abstract [en]

    The conservation of textiles is a challenge due to the often fast degradation that results from the acidity combined with a complex structure that requires remediation actions to be conducted at several length scales. Nanomaterials have lately been used for various purposes in the conservation of cultural heritage. The advantage with these materials is their high efficiency combined with a great control. Here, we provide an overview of the latest developments in terms of nanomaterials-based alternatives, namely inorganic nanoparticles and nanocellulose, to conventional methods for the strengthening and deacidification of cellulose-based materials. Then, using the case of iron-tannate dyed cotton, we show that conservation can only be addressed if the mechanical strengthening is preceded by a deacidification step. We used CaCO3 nanoparticles to neutralize the acidity, while the stabilisation was addressed by a combination of nanocellulose, and silica nanoparticles, to truly tackle the complexity of the hierarchical nature of cotton textiles. Silica nanoparticles enabled strengthening at the fibre scale by covering the fibre surface, while the nanocellulose acted at bigger length scales. The evaluation of the applied treatments, before and after an accelerated ageing, was assessed by tensile testing, the fibre structure by SEM and the apparent colour changes by colourimetric measurements.

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  • Grander, Martin
    Malmö University, Faculty of Culture and Society (KS), Department of Urban Studies (US).
    Segmentering i bostadsbeståndet 2013-2017: Utveckling av bostadsbestånd, demografi och socioekonomiska indikatorer i riket och storstäderna, med fördjupningar i Malmö och Göteborg2020Report (Other academic)
    Abstract [sv]

    Denna rapport, utarbetad inom ramen för forskningsprogrammet Nyttan med allmännyttan i praktiken samt forskningsprojektet Allmännyttan och blandningspolitikens praktik (Formas 2018-00063) vid Malmö universitets forskningsmiljö Studier i boende och välfärd (http://www.mau.se/sbv), presenterar en beskrivning och analys av befolkningsutvecklingen och förändringar i bostadsbeståndet mellan åren 2013–2017. Närmare bestämt studeras utvecklingen av bostadsbeståndet samt den demografiska förändringen och utvecklingen av befolkningens socioekonomiska förutsättningar per upplåtelseform i Sverige samt i storstadskommunerna Stockholm, Göteborgoch Malmö. Särskilda fördjupningar görs i Göteborg och Malmö. Syftet med texten är att utifrån de statistiska underlagen belysa och diskutera de olika upplåtelseformernas roll och funktion på lokala bostadsmarknader i demografisk förändring, med särskilt fokus på den allmännyttiga bostadssektorn.

    Rapporten pekar på en kraftig inkomstsegmentering mellan upplåtelseformerna, det vill säga att olika upplåtelseformer får alltmer ensartad sammansättning av hushåll när det gäller disponibel inkomst. Hyresrätten – och specifikt allmännyttan – blir i allt högre utsträckning en boendeform för hushåll med låga inkomster, medan inkomsterna i bostadsrätt och egnahem ökar betydligt mer än den generella utvecklingen. Denna utveckling i allmännyttan har pågått under en längre tid, men accentueras under perioden 2013–2017, där allmännyttan får en allt större andel hushåll inkomstfattiga. Nästan vartannat hushåll i allmännyttan har låg köpkraft. Samtidigt ser vi att andelen hushåll med hög köpkraft koncentreras i bostadsrätt. Vidare ökar segmenteringen mellan allmännyttig och privat hyresrätt kontinuerligt, vilket i praktiken innebär att den så kallade integrerade hyresmarknaden, där privata och allmännyttiga hyresvärdar konkurrerar om samma hyresgäster, alltmer framstår som en idealbild.

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    Grander (2020) Segmentering i bostadsbeståndet 2013–2017
  • Ablikim, M.
    et al.
    Inst High Energy Phys, Beijing 100049, Peoples R China.
    Adlarson, Patrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Biernat, Jacek
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Ikegami Andersson, Walter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Li, Cui
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Papenbrock, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Pettersson, Joachim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Thorén, Viktor
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Wolke, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Zou, J. H.
    Inst High Energy Phys, Beijing 100049, Peoples R China.
    Observation of the semimuonic decay D+→ωμ+νμ2020In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 101, no 7, article id 072005Article in journal (Refereed)
    Abstract [en]

    We report the first observation of the semimuonic decay D+ -> omega mu(+)upsilon(mu) using an e(+)e(-) collision data sample corresponding to an integrated luminosity of 2.93 fb(-1) collected with the BESIII detector at a center-of-mass energy of 3.773 GeV. The absolute branching fraction of the D+ -> omega mu(+)upsilon(mu) decay is measured to be BD+ -> omega mu(+)upsilon mu = (17.7 +/- 1.8(stat) +/- 1.1(syst)) x 10(-4). Its ratio with the world average value of the branching fraction of the D+ -> omega e(+)upsilon(mu) decay probes lepton flavor universality and it is determined to be BD+ -> omega mu(+)upsilon mu/BD+ -> omega mu(+)upsilon e(PDG) = 1.05 +/- 0.14, in agreement with the standard model expectation within one standard deviation.

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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio de cultu dei externo et publico, quam, consensu ampliss. facult. philos. ad regium lyceum upsal. præside Mag. Joh. P. Sleincour, ... alumnus Guthermuthianus Matthias Ahlinder, Uplandus. In audit. Gustav. maj. d. 12 Junii 1782.1782Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio gradualis, de indole et veritate virtutis philosophicæ, quam, consensu ampliss. facult. philosoph. in reg. acad. upsaliensi præside Mag. Johan. Pet. Sleincour, ... Olavus Ol. Högman, stipendiarius regius Uplandus. In aud. Gust. maj. d. X. Junii. MDCCLXXXII.1782Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio, de studio naturæ humanæ in legibus ferendis necessario, quam, venia ampliss. facult. philos. praeside Mag. Johan. Petr. Sleincour, ... Andreas Leufvenius, stipend. Nessel. Fjerdhundr. In audit. Gust. maj. d. 12 April. 1782. ... pars I.1782Dissertation (older thesis) (Other academic)
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  • Sleincour, Johan Peter
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio philosophica de cognitione viva, quam, venia ampliss. facult. philos. sub auspiciis Mag. Johannis Petri Sleincour, ... auctor Salomon Martinus Sundelius, Vermelandus. In audit. Gust. maj. d. XII. Dec. MDCCLXXXI.1781Dissertation (older thesis) (Other academic)
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