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  • Hambäck, Peter A.
    et al.
    Hambäck, Peter A.
    Weingartner, Elisabeth
    Dalén, Love
    Swedish Museum of Natural History, Department of Bioinformatics and Genetics.
    Wirta, Helena
    Roslin, Tomas
    Spatial subsidies in spider diets vary with shoreline structure: Complementary evidence from molecular diet analysis and stable isotopes2016In: Ecology and Evolution, ISSN 2045-7758, E-ISSN 2045-7758, Vol. 6, no 23, 8431-8439 p.Article in journal (Refereed)
  • Cederlöf, Gunnel
    Linnaeus University, Faculty of Arts and Humanities, Department of Cultural Sciences.
    Cederlöf, Gunnel
    Linnaeus University, Faculty of Arts and Humanities, Department of Cultural Sciences.
    Rule against Nature: Founding an Empire on India’s North-Eastern Frontier2013Book (Refereed)
  • Johansson, Tobias
    Kristianstad University, School of Education and Environment, Avdelningen för Psykologi.
    Johansson, Tobias
    Kristianstad University, School of Education and Environment, Avdelningen för Psykologi.
    Generating Artificial Social NetworksManuscript (preprint) (Other academic)
  • Hjort, Adam
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Hjort, Adam
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Synthetic photometry of M-type AGB stars with JWST & WISE2017Report (Other academic)
    Abstract [en]

    In this study we present a data set of synthetic photometry of M-type AGB stars for JWST, WISE and a filter set that will be referred to as the generic lter set, consisting of: UX BX B V R I J J2m H H2m Ks2m K L L' M M'. 106 dierent models compromised of 4741 spectra have been processed for the three filter sets. We have also fitted the models to eight observations of M-type AGB stars made by WISE, showing that the models fairly well can recreate observations but that there is definitely still room for improvements. The resulting photometric files can be accessed at http://www.astro.uu.se/AGBmodels/ABmags

  • Simons, Greg
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Uppsala Centre for Russian and Eurasian Studies.
    Simons, Greg
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Uppsala Centre for Russian and Eurasian Studies.
    book review of Carnage and Connectivity: Landmarks in the Decline of Conventional Military Power by David Betz2017In: Technology and culture, ISSN 0040-165X, E-ISSN 1097-3729, Vol. 58, no 1, 290-291 p.Article, book review (Other academic)
  • Löfmarck, Erik
    et al.
    Örebro University, School of Humanities, Education and Social Sciences, Örebro University, Sweden.
    Löfmarck, Erik
    Örebro University, School of Humanities, Education and Social Sciences, Örebro University, Sweden.
    Lidskog, Rolf
    Örebro University, School of Humanities, Education and Social Sciences, Örebro University, Sweden.
    Bumping against the boundary: IPBES and the knowledge divide2017In: Environmental Science and Policy, ISSN 1462-9011, E-ISSN 1873-6416, Vol. 69, 22-28 p.Article in journal (Refereed)
    Abstract [en]

    Founded in 2012, the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) is one of the most ambitious attempts to date to bridge the divide between scientific knowledge and indigenous and local knowledge. Doing so requires overcoming participatory, epistemological and ontological challenges, including different communicative forms, diverging criteria for knowledge validation, and conflicting views of nature. Central IPBES documents are analyzed to see how the platform deals with these challenges. While IPBES constitutes an unprecedented, innovative and ambitious institutional design for the cross-fertilization of knowledge, the results show that IPBES (i) struggles to reconcile an open, collaborative atmosphere with the demands for structure set by the scientific format, (ii) tends to shy away from potentially conflict-laden issues and disagreements, (iii) often treats scientific knowledge and indigenous or local knowledge as easily distinguishable entities, and (iv) has yet to solve the epistemological challenges of knowledge generation and validation when working across knowledge-systems. Taken together, these features seem to hinder the cross-fertilization of knowledge. The case of IPBES thus holds important lessons for future efforts to transform both knowledge production and the overall framing of challenges within global environmental governance.

  • Dobrenel, Thomas
    et al.
    Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). Umeå University, Faculty of Science and Technology, Department of Plant Physiology. Institut Jean-Pierre Bourgin, Institut National de la Recherche Agronomique, AgroParisTech, Centre National de la Recherche Scientifique, Université Paris-Saclay, Versailles, France; Université Paris-Sud–Université Paris-Saclay, Orsay, France.
    Dobrenel, Thomas
    Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). Umeå University, Faculty of Science and Technology, Department of Plant Physiology. Institut Jean-Pierre Bourgin, Institut National de la Recherche Agronomique, AgroParisTech, Centre National de la Recherche Scientifique, Université Paris-Saclay, Versailles, France; Université Paris-Sud–Université Paris-Saclay, Orsay, France.
    Mancera-Martinez, Eder
    Forzani, Celine
    Azzopardi, Marianne
    Davanture, Marlene
    Moreau, Manon
    Schepetilnikov, Mikhail
    Chicher, Johana
    Langella, Olivier
    Zivy, Michel
    Robaglia, Christophe
    Ryabova, Lyubov A.
    Hanson, Johannes
    Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). Umeå University, Faculty of Science and Technology, Department of Plant Physiology.
    Meyer, Christian
    The Arabidopsis TOR Kinase Specifically Regulates the Expression of Nuclear Genes Coding for Plastidic Ribosomal Proteins and the Phosphorylation of the Cytosolic Ribosomal Protein S62016In: Frontiers in Plant Science, ISSN 1664-462X, E-ISSN 1664-462X, Vol. 7, 1611Article in journal (Refereed)
    Abstract [en]

    Protein translation is an energy consuming process that has to be fine-tuned at both the cell and organism levels to match the availability of resources. The target of rapamycin kinase (TOR) is a key regulator of a large range of biological processes in response to environmental cues. In this study, we have investigated the effects of TOR inactivation on the expression and regulation of Arabidopsis ribosomal proteins at different levels of analysis, namely from transcriptomic to phosphoproteomic. TOR inactivation resulted in a coordinated down-regulation of the transcription and translation of nuclear-encoded mRNAs coding for plastidic ribosomal proteins, which could explain the chlorotic phenotype of the TOR silenced plants. We have identified in the 5' untranslated regions (UTRs) of this set of genes a conserved sequence related to the 5' terminal oligopyrimidine motif, which is known to confer translational regulation by the TOR kinase in other eukaryotes. Furthermore, the phosphoproteomic analysis of the ribosomal fraction following TOR inactivation revealed a lower phosphorylation of the conserved Ser240 residue in the C-terminal region of the 40S ribosomal protein S6 (RPS6). These results were confirmed by Western blot analysis using an antibody that specifically recognizes phosphorylated Ser240 in RPS6. Finally, this antibody was used to follow TOR activity in plants. Our results thus uncover a multi-level regulation of plant ribosomal genes and proteins by the TOR kinase.

  • Högberg, Anders
    et al.
    Linnaeus University, Faculty of Arts and Humanities, Department of Cultural Sciences.
    Högberg, Anders
    Linnaeus University, Faculty of Arts and Humanities, Department of Cultural Sciences.
    Holtorf, Cornelius
    Linnaeus University, Faculty of Arts and Humanities, Department of Cultural Sciences.
    Långtidsförvaring av kärnavfall: Från samtidsarkeologi till framtidsarkeologi2016In: Primitive tider, ISSN 1501-0430, Vol. 18, 285-295 p.Article in journal (Refereed)
    Abstract [en]

    All countries that manage nuclear waste will need to store it for a long time. When all the reactors in Sweden have been taken out of use there will be around 12,000 tonnes of highly radioactive waste. For the future safety of humans and nature, the plan is to store the waste for 100,000 years in tunnels drilled 500 metres under ground. Once the waste is in place and the nal repositories are closed, society will be faced with the task of nding ways to keep knowledge of these places alive for a very long time to come. The task is unique. Never before has anyone created information and knowledge intended for someone thousands of years into the future. Between 2012 and 2015 we have worked with the project “One hundred thousand years back and forth – archaeology meets radioactive waste”. We have studied how one can think about past, present and future and about the resources that are needed if we are to be able to envisage a future extending over thousands of years. From a theoretical discussion on the concept of future consciousness, we argue that nal repositories for nuclear waste must be built in a exible manner to be able to work in different ways in relation to many different futures. Storage of radioactive waste embraces noticeable aspects of materiality, and relevant planning and decision-making processes can bene t from archaeological expertise. Long-time nal repositories of nuclear waste also pose challenges to contemporary archaeology. Various ways to conceptualize futures are part of our contemporary society. This has not been studied to any great extent within the eld archaeology of the contemporary world. It is likely that we will hear more in time to come about future consciousness in contemporary archaeology, then in the form of future archaeology. 

  • Andresen, Liis
    et al.
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
    Andresen, Liis
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
    Tenson, Tanel
    Hauryliuk, Vasili
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). University of Tartu, Institute of Technology, Nooruse 1, 50411 Tartu, Estonia.
    Cationic bactericidal peptide 1018 does not specifically target the stringent response alarmone (p)ppGpp2016In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, 36549Article in journal (Refereed)
    Abstract [en]

    The bacterial stringent response is a key regulator of bacterial virulence, biofilm formation and antibiotic tolerance, and is a promising target for the development of new antibacterial compounds. The intracellular nucleotide (p)ppGpp acts as a messenger orchestrating the stringent response. A synthetic peptide 1018 was recently proposed to specifically disrupt biofilms by inhibiting the stringent response via direct interaction with (p) ppGpp (de la Fuente-Nunez et al. (2014) PLoS Pathogens). We have interrogated the specificity of the proposed molecular mechanism. When inhibition of Pseudomonas aeruginosa planktonic and biofilm growth is tested simultaneously in the same assay, peptides 1018 and the control peptide 8101 generated by an inversion of the amino acid sequence of 1018 are equally potent, and, importantly, do not display a preferential activity against biofilm. 1018 inhibits planktonic growth of Escherichia coli equally efficiently either when the alleged target, (p) ppGpp, is essential (MOPS media lacking amino acid L-valine), or dispensable for growth (MOPS media supplemented with L-valine). Genetic disruption of the genes relA and spoT responsible for (p) ppGpp synthesis moderately sensitizes-rather than protects-E. coli to 1018. We suggest that the antimicrobial activity of 1018 does not rely on specific recognition of the stringent response messenger (p) ppGpp.

  • Garcia-Ptacek, Sara
    et al.
    Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
    Garcia-Ptacek, Sara
    Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Cermakova, Pavla
    Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
    Rizzuto, Debora
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    Religa, Dorota
    Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden.
    Eriksdotter, Maria
    Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
    Causes of Death According to Death Certificates in Individuals with Dementia: A Cohort from the Swedish Dementia Registry.2016In: Journal of The American Geriatrics Society, ISSN 0002-8614, E-ISSN 1532-5415, Vol. 64, no 11, e137-e142 p.Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: The causes of death in dementia are not established, particularly in rarer dementias. The aim of this study is to calculate risk of death from specific causes for a broader spectrum of dementia diagnoses.

    DESIGN: Cohort study.

    SETTING: Swedish Dementia Registry (SveDem), 2007-2012.

    PARTICIPANTS: Individuals with incident dementia registered in SveDem (N = 28,609); median follow-up 741 days. Observed deaths were 5,368 (19%).

    MEASUREMENTS: Information on number of deaths and causes of mortality was obtained from death certificates. Odds ratios for the presence of dementia on death certificates were calculated. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox hazards regression for cause-specific mortality, using Alzheimer's dementia (AD) as reference. Hazard ratios for death for each specific cause of death were compared with hazard ratios of death from all causes (P-values from t-tests).

    RESULTS: The most frequent underlying cause of death in this cohort was cardiovascular (37%), followed by dementia (30%). Dementia and cardiovascular causes appeared as main or contributory causes on 63% of certificates, followed by respiratory (26%). Dementia was mentioned less in vascular dementia (VaD; 57%). Compared to AD, cardiovascular mortality was higher in individuals with VaD than in those with AD (HR = 1.82, 95% CI = 1.64-2.02). Respiratory death was higher in individuals with Lewy body dementia (LBD, including Parkinson's disease dementia and dementia with Lewy bodies, HR = 2.16, 95% CI = 1.71-2.71), and the risk of respiratory death was higher than expected from the risk for all-cause mortality. Participants with frontotemporal dementia were more likely to die from external causes of death than those with AD (HR = 2.86, 95% CI = 1.53-5.32).

    CONCLUSION: Dementia is underreported on death certificates as main and contributory causes. Individuals with LBD had a higher risk of respiratory death than those with AD.

  • Ganai, Rais A.
    et al.
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, USA.
    Ganai, Rais A.
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, USA.
    Zhang, Xiao-Ping
    Heyer, Wolf-Dietrich
    Johansson, Erik
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Strand displacement synthesis by yeast DNA polymerase epsilon2016In: Nucleic Acids Research, ISSN 0305-1048, E-ISSN 1362-4962, Vol. 44, no 17, 8229-8240 p.Article in journal (Refereed)
    Abstract [en]

    DNA polymerase epsilon (Pol epsilon) is a replicative DNA polymerase with an associated 3'aEuro"5' exonuclease activity. Here, we explored the capacity of Pol epsilon to perform strand displacement synthesis, a process that influences many DNA transactions in vivo. We found that Pol epsilon is unable to carry out extended strand displacement synthesis unless its 3'aEuro"5' exonuclease activity is removed. However, the wild-type Pol epsilon holoenzyme efficiently displaced one nucleotide when encountering double-stranded DNA after filling a gap or nicked DNA. A flap, mimicking a D-loop or a hairpin structure, on the 5' end of the blocking primer inhibited Pol epsilon from synthesizing DNA up to the fork junction. This inhibition was observed for Pol epsilon but not with Pol delta, RB69 gp43 or Pol eta. Neither was Pol epsilon able to extend a D-loop in reconstitution experiments. Finally, we show that the observed strand displacement synthesis by exonuclease-deficient Pol epsilon is distributive. Our results suggest that Pol epsilon is unable to extend the invading strand in D-loops during homologous recombination or to add more than two nucleotides during long-patch base excision repair. Our results support the hypothesis that Pol epsilon participates in short-patch base excision repair and ribonucleotide excision repair.

  • Molander Danielsson, Karin
    Mälardalen University, School of Education, Culture and Communication.
    Molander Danielsson, Karin
    Mälardalen University, School of Education, Culture and Communication.
    Detektivserien, en genre under utveckling2005In: LITTERATUR OCH SPRÅK: Ekokritik, Jean-Henri Fabre, Återvinningens estetik, Kerstin Ekman, Posthumanism, Elektriska får och mekaniska människor, Djurkaraktärer, Kultur och hållbar utveckling, Västerås: Mälardalens högskola , 2005, no 5, 82-92 p.Chapter in book (Other academic)
  • Lucas, P
    et al.
    VSL Dutch Metrology Institute, Delft, The Netherlands.
    Lucas, P
    VSL Dutch Metrology Institute, Delft, The Netherlands.
    Buker, O
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Mätteknik, Volym, flöde, temperatur o densitet.
    Kenbar, S
    NEL, Glasgow, Scotland.
    Kolbjornsen, H
    Justervesenet, Kjeller, Norway.
    Rathwell, G
    OGM, Ely, United Kingdom.
    Safonova, M
    IMS, Moscow, Russia.
    Stolt, K
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Mätteknik, Volym, flöde, temperatur o densitet.
    van der Beek, MP
    VSL Dutch Metrology Institute, Delft, The Netherlands.
    World’s first LNG research and calibration facility2016Conference paper (Refereed)
    Abstract [en]

    A Liquefied Natural Gas (LNG) flowmeter research and calibration facility is being built in Rotterdam by the Dutch metrology institute VSL. This cryogenic test loop will also be used to test and develop LNG analysers, new technologies and devices for measurement of LNG physical properties. The facility will consist of a Primary Standard Loop (PSL) that can measure the mass of LNG flows traceable to the International Kilogram standard in Paris. The primary standard is capable of flow measurements up to 25 m3/hr. A second Midscale Standard Loop (MSL) will measure volumetric flow rate of up to 200 m3/h, expandable to at least 400 m3/h in the future. The Midscale standard is traceable to the PSL and scales the flowrate up using bootstrapping techniques. This paper describes the combined PSL and MSL facility, its objectives, and accomplishments to date.

  • Hellström, Gustav
    et al.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Hellström, Gustav
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Klaminder, Jonatan
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Finn, Fia
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Persson, Lo
    Alanärä, Anders
    Jonsson, Micael
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Fick, Jerker
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Brodin, Tomas
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    GABAergic anxiolytic drug in water increases migration behaviour in salmon2016In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 7, 13460Article in journal (Refereed)
    Abstract [en]

    Migration is an important life-history event in a wide range of taxa, yet many migrations are influenced by anthropogenic change. Although migration dynamics are extensively studied, the potential effects of environmental contaminants on migratory physiology are poorly understood. In this study we show that an anxiolytic drug in water can promote downward migratory behaviour of Atlantic salmon (Salmo salar) in both laboratory setting and in a natural river tributary. Exposing salmon smolt to a dilute concentration of a GABAA receptor agonist (oxazepam) increased migration intensity compared with untreated smolt. These results implicate that salmon migration may be affected by human-induced changes in water chemical properties, such as acidification and pharmaceutical residues in wastewater effluent, via alterations in the GABAA receptor function.

  • Eggenschwiler, Reto
    et al.
    Eggenschwiler, Reto
    Moslem, Mohsen
    Fráguas, Mariane Serra
    Galla, Melanie
    Papp, Oliver
    Naujock, Maximilian
    Fonfara, Ines
    Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Max Planck Institute for Infection Biology, Department of Regulation in Infection Biology, Berlin, Germany.
    Gensch, Ingrid
    Wähner, Annabell
    Beh-Pajooh, Abbas
    Mussolino, Claudio
    Tauscher, Marcel
    Steinemann, Doris
    Wegner, Florian
    Petri, Susanne
    Schambach, Axel
    Charpentier, Emmanuelle
    Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Cathomen, Toni
    Cantz, Tobias
    Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase2016In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, 38198Article in journal (Refereed)
    Abstract [en]

    Homology directed repair (HDR)-based genome editing via selectable long flanking arm donors can be hampered by local transgene silencing at transcriptionally silent loci. Here, we report efficient bi-allelic modification of a silent locus in patient-derived hiPSC by using Cas9 nickase and a silencing-resistant donor construct that contains an excisable selection/counter-selection cassette. To identify the most active single guide RNA (sgRNA)/nickase combinations, we employed a lentiviral vector-based reporter assay to determine the HDR efficiencies in cella. Next, we used the most efficient pair of sgRNAs for targeted integration of an improved, silencing-resistant plasmid donor harboring a piggyBac-flanked puro Delta tk cassette. Moreover, we took advantage of a dual-fluorescence selection strategy for bi-allelic targeting and achieved 100% counter-selection efficiency after bi-allelic excision of the selection/counter-selection cassette. Together, we present an improved system for efficient bi-allelic modification of transcriptionally silent loci in human pluripotent stem cells.

  • Gunnarsson, Åsa
    et al.
    Umeå University, Faculty of Social Sciences, Umeå Forum for Studies on Law and Society.
    Gunnarsson, Åsa
    Umeå University, Faculty of Social Sciences, Umeå Forum for Studies on Law and Society.
    Eriksson, Martin
    Umeå University, Faculty of Social Sciences, Umeå Forum for Studies on Law and Society.
    Discussion Paper on Tax Policy and Tax Principles in Sweden, 1902-20162017Report (Refereed)
    Abstract [en]

    The long time perspective on tax principles and tax policies in this discussion paper identifies some of the most important and relevant contexts for major Swedish tax reforms from 1902 until the present time. Until the 1991 tax reform principles played a significant role in tax law design. The relation between principles and legal concepts was quite consistent.

    However, the 1991 tax reform seems to mark the end of a period when Swedish governments, with a certain regularity, initiated tax reforms to tackle contemporary economic and social challenges. In spite of several initiatives, proposed in well investigated study commission reports, no comprehensive tax reforms have been launched during a quarter of a decade. Instead hundreds of small, partial reforms have been implemented in tax law. Together with a new budgetary framework these gradual changes have changed the overall revenue basis for the public sector and the welfare state. In tandem with this development, the policy discourse on taxing for economic growth has increasingly gained in influence.

    Even though environmental sustainability, and later also fiscal sustainability, have been prominent in the design of the tax system, we also note that Swedish tax policy has potential to further integrate important economic and social sustainability goals such as gender equality, social inclusion and income distribution.

    A result of the study is to show the complexity of a national agenda on tax policy. Legally enshrined goals and principles cannot easily be superseded with tax policies on a supranational level, particularly if these policies are solely drawn from macroeconomic analysis on the mechanisms and trajectories of economic crises.

  • Public defence: 2017-02-17 10:00 Kollegiesalen
    Anderson, Mattias
    KTH, School of Biotechnology (BIO), Industrial Biotechnology.
    Anderson, Mattias
    KTH, School of Biotechnology (BIO), Industrial Biotechnology.
    Amine Transaminases in Multi-Step One-Pot Reactions2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Amine transaminases are enzymes that catalyze the mild and selective formation of primary amines, which are useful building blocks for biologically active compounds and natural products. In order to make the production of these kinds of compounds more efficient from both a practical and an environmental point of view, amine transaminases were incorporated into multi-step one-pot reactions. With this kind of methodology there is no need for isolation of intermediates, and thus unnecessary work-up steps can be omitted and formation of waste is prevented. Amine transaminases were successfully combined with other enzymes for multi-step synthesis of valuable products: With ketoreductases all four diastereomers of a 1,3-amino alcohol could be obtained, and the use of a lipase allowed for the synthesis of natural products in the form of capsaicinoids. Amine transaminases were also successfully combined with metal catalysts based on palladium or copper. This methodology allowed for the amination of alcohols and the synthesis of chiral amines such as the pharmaceutical compound Rivastigmine. These examples show that the use of amine transaminases in multi-step one-pot reactions is possible, and hopefully this concept can be further developed and applied to make industrial processes more sustainable and efficient in the future.

  • Johansson, Maria
    et al.
    Johansson, Maria
    Sandström, Camilla
    Umeå University, Faculty of Social Sciences, Department of Political Science.
    Pedersen, Eja
    Ericsson, Göran
    Factors governing human fear of wolves: moderating effects of geographical location and standpoint on protected nature2016In: European Journal of Wildlife Research, ISSN 1612-4642, E-ISSN 1439-0574, Vol. 62, no 6, 749-760 p.Article in journal (Refereed)
    Abstract [en]

    This study analyses psychological antecedents of feelings of fear of wolves in a proportional sample of the Swedish population (national sample, n = 545) and in a sample of people in counties with wolf presence (regional sample, n = 1,892). Structural equation modelling of survey data suggests a dual pathway to self-reported fear. One path encompasses the appraisal of the environmental context operationalised as a potential wolf encounter. The second path concerns the appraisal of the social context assessed as social trust in managing authorities. The relative importance of the paths differs between the national and the regional sample, and between people in the administrative centre of the region and the regional periphery. We show that the public's fear of wolves should be addressed both at an individual level, focusing on situations with potential encounters, and at a collective level, by strengthening the trust between the public and authorities, and regional variation should be considered.

  • Salminen, Eero
    et al.
    Salminen, Eero
    Virtanen, Pasi
    Mikkola, Jyri-Pekka
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Laboratory of Industrial Chemistry and Reaction Engineering, Process Chemistry Centre, Åbo Akademi University, Åbo-Turku, Finland.
    Alkaline ionic liquids applied in supported ionic liquid catalyst for selective hydrogenation of citral to citronellal2014In: Frontiers in Chemistry, E-ISSN 2296-2646, Vol. 2, 3Article in journal (Refereed)
    Abstract [en]

    The challenge in preparation of ionic liquids containing a strong alkaline anion is to identify a suitable cation which can tolerate the harsh conditions induced by the anion. In this study, a commercial quaternary ammonium compound (quat) benzalkonium [ADBA] (alkyldimethylbenzylammonium) was used as a cation in the synthesis of different alkaline ionic liquids. In fact, the precursor, benzalkonium chloride, is a mixture of alkyldimethylbenzylammonium chlorides of various alkyl chain lengths and is commonly used in the formulation of various antiseptic products. The prepared ionic liquids were utilized as Supported Ionic Liquid Catalysts (SILCAs). Typically, a SILCA contains metal nanoparticles, enzymes, or metal complexes in an ionic liquid layer which is immobilized on a solid carrier material such as an active carbon cloth (ACC). The catalysts were applied in the selective hydrogenation of citral to citronellal which is an important perfumery chemical. Interestingly, 70% molar yield toward citronellal was achieved over a catalyst containing the alkaline ionic liquid benzalkonium methoxide.

  • Henricson, Anders
    et al.
    Henricson, Anders
    Nilsson, Kjell G.
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Orthopaedics.
    Trabecular metal tibial knee component still stable at 10 years: An RSA study of 33 patients less than 60 years of age2016In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 87, no 5, 504-510 p.Article in journal (Refereed)
    Abstract [en]

    Background and purpose - Total knee replacement (TKR) in younger patients using cemented components has shown inferior results, mainly due to aseptic loosening. Excellent clinical results have been reported with components made of trabecular metal (TM). In a previous report, we have shown stabilization of the TM tibial implants for up to 5 years. In this study, we compared the clinical and RSA results of these uncemented implants with those of cemented implants. Patients and methods - 41 patients (47 knees) aged 60 years underwent TKR. 22 patients (26 knees) received an uncemented monoblock cruciate-retaining (CR) tibial component (TM) and 19 patients (21 knees) received a cemented NexGen Option CR tibial component. Follow-up examination was done at 10 years, and 16 patients (19 knees) with TM tibial components and 17 patients (18 knees) with cemented tibial components remained for analysis. Results - 1 of 19 TM implants was revised for infection, 2 of 18 cemented components were revised for knee instability, and no revisions were done for loosening. Both types of tibial components migrated in the first 3 months, the TM group to a greater extent than the cemented group. After 3 months, both groups were stable during the next 10 years. Interpretation - The patterns of migration for uncemented TM implants and cemented tibial implants over the first 10 years indicate that they have a good long-term prognosis regarding fixation

  • Wahlberg, Per
    et al.
    Wahlberg, Per
    Lundmark, Anders
    Nordlund, Jessica
    Busche, Stephan
    Raine, Amanda
    Tandre, Karolina
    Rönnblom, Lars
    Sinnett, Daniel
    Forestier, Erik
    Umeå University, Faculty of Medicine, Department of Medical Biosciences.
    Pastinen, Tomi
    Lönnerholm, Gudmar
    Syvänen, Ann-Christine
    DNA methylome analysis of acute lymphoblastic leukemia cells reveals stochastic de novo DNA methylation in CpG islands2016In: Epigenomics, ISSN 1750-1911, Vol. 8, no 10, 1367-1387 p.Article in journal (Refereed)
    Abstract [en]

    Aim: To identify regions of aberrant DNA methylation in acute lymphoblastic leukemia (ALL) cells of different subtypes on a genome-wide scale. Materials & methods: Whole-genome bisulfite sequencing (WGBS) was used to determine the DNA methylation levels in cells from four pediatric ALL patients of different subtypes. The findings were confirmed by 450k DNA methylation arrays in a large patient set. Results: Compared with mature B or T cells WGBS detected on average 82,000 differentially methylated regions per patient. Differentially methylated regions are enriched to CpG poor regions, active enhancers and transcriptional start sites. We also identified approximately 8000 CpG islands with variable intermediate DNA methylation that seems to occur as a result of stochastic de novo methylation. Conclusion: WGBS provides an unbiased view and novel insights into the DNA methylome of ALL cells.

  • Henriksson, Malin
    et al.
    Swedish National Road and Transport Research Institute, Society, environment and transport, Mobility, actors and planning processes.
    Henriksson, Malin
    Swedish National Road and Transport Research Institute, Society, environment and transport, Mobility, actors and planning processes.
    Friberg, Emma
    Östergötlands museum.
    Kusmin, Elin
    Östergötlands museum.
    Otterbeck, Emelie
    "Om nåt skulle hända": Ett gestaltningsprojekt om ungas upplevelser av otrygghet i utemiljöer2016Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    Under 2016 producerade Statens väg- och transportforskningsinstitut (VTI) tillsammans med Östergötlands museum en vandringsutställning om ungas upplevelser av otrygghet. Projektet finansierades av Boverket inom utlysningen ”stöd till utvecklingsprojekt för jämställda offentliga miljöer i städer och tätorter”.  

    Projektet utgår från problematiken att ungdomars upplevelser av otrygghet sällan kommer till uttryck i stadsplaneringen. Inte heller i forskningen om upplevelser av våld och otrygghet i det offentliga rummet uppmärksammas ungdomar i särskilt hög grad. Samtidigt förflyttar sig ungdomar som grupp mer än andra grupper och vistas i högre grad utomhus. De är också utomhus på andra tidpunkter än vuxna, på kvällen och natten. Vidare är ungdomar, oavsett kön, mer utsatta för våld utomhus än andra grupper. Det är därför att utveckla nya verktyg för att belysa ungdomars erfarenheter av otrygghet i utomhusmiljöer.

    Underlaget för utställningen utgjordes av gruppintervjuer med ett fyrtiotal ungdomar (killar, tjejer och transpersoner) mellan 13 och 20 år. Den feministiska metoden minnesarbete användes för att underlätta samtal om trygghet, otrygghet och rädsla. Metoden går ut på att deltagarna i en grupp skriver individuella minnen på ett på förhand bestämt tema. Minnena tolkas sedan kollektivt i gruppen.

    Intervjuerna tolkades och bearbetades av projektgruppen. Utifrån tolkningsprocessen gestaltades ungdomarnas erfarenheter dels fotografiskt och dels i text. Fyra fiktiva karaktärer togs fram och i utställningen får besökaren följa dem hem. Milo, David, Jo och Semira har alla olika erfarenheter och upplever olika moment i staden och hemresan som otrygga. Vidare togs en pedagogisk handledning fram. Den pedagogiska handledningen innehåller förslag på övningar som fördjupar utställningens teman. Den fungerar som ett stöd för skolor som hyr utställningen och kan användas av lärare i undervisningen. Pedagoger från Östergötlands museum kan vidare leda lektioner som bygger på handledningen om skolan så önskar.

    Projektet avslutades med en fyra veckor lång turné där ungdomar i olika åldrar fick ta del av utställningen och arbeta med den pedagogiskt. Turnén utvärderades med genomgående goda resultat.

    Projektet bidrar avslutningsvis till att stärka planeringen av jämställda miljöer på två sätt. För det första ger utställningen insikter om hur unga människor upplever trygghet i utemiljöer. För det andra är utställningen ett verktyg som gör det möjligt att praktiskt arbeta med frågorna pedagogiskt i skolmiljöer, eller i stadsplaneringssammanhang med planerare och andra aktörer.

  • Borch, Elisabeth
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Food and Bioscience, Microbiology.
    Borch, Elisabeth
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Food and Bioscience, Microbiology.
    Green Cleaning - Utveckling av testbädden Cleaning Innovation2017Report (Other academic)
    Abstract [sv]

    En ökad användning av miljösmart teknik och förfarande vid rengöring och desinfektion i livsmedelsindustrin förväntas leda till mindre miljöpåverkan genom mindre vatten-, energi-, kemikalie- och materialförbrukning och mindre matsvinn. Detta gynnar också tillväxten hos miljöteknikföretag som bidrar med gröna lösningar. Testbädden Cleaning Innovation (www.cleaninginnovation.se) medverkar till utveckling av miljösmarta och effektiva metoder för rengöring och desinfektion i många branscher. Huvudintressenter är leverantörer/utvecklare av kemikalier, utrustning eller material; hygienföretag; livsmedelsföretag; offentliga aktörer. Cleaning Innovation, som ägs av RISE, är en öppen, oberoende testbädd och erbjuder utvärdering av teknik, kemikalier, material, utrustning och metoder. Testbädden bygger på samverkan mellan olika typer av verksamheter inom RISE (Research Institutes of Sweden) inriktade mot mikrobiologi, miljö, processteknik, certifiering, mätteknik, kemi, material, energiteknik samt med hygienteknikföretaget Lagafors AB. Inom Cleaning Innovation finns marknadskunskap, tvärvetenskaplig kompetens, analys-, beräknings- och mätutrustning, laboratorier samt testutrustningar i pilotskala. I projektet utvecklades befintlig verksamhet avseende testlokal, utrustning och produkterbjudande. Ett viktigt resultat från projektet är att vi har genomfört mer än 10 projekt där utvärdering av renhet och desinfektion görs med kunder. Eftersom detta är betydligt mer än planerat har egen finansiering blev betydligt högre än budgeterad. Detta visar på ett bra utbud och en tydlig marknad. Vi har också breddat vår målgrupp och inkluderar nu alla branscher med behov av rengöring och desinfektion; i motsats till bara livsmedelsindustrin som beskrivit i projektansökan.

    Testbädden Cleaning Innovation lanserades 29 november 2016. Cleaning Innovations utveckling i framtiden ser ljus ut och har en stark och naturlig förankring inom RISE. Framtidsplanerna involverar ett succesivt bräddande till kunder inom fler industrityper och en långsam expansion av verksamheten.

  • Public defence: 2017-02-07 09:00 Häggsalen, Uppsala
    Saarinen, Linn
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Saarinen, Linn
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    The Frequency of the Frequency: On Hydropower and Grid Frequency Control2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Variations in the electricity consumption and production connected to the power system have to be balanced by active control. Hydropower is the most important balancing resource in the Nordic system, and will become even more important as the share of variable renewable energy sources increases. This thesis concerns balancing of active power, especially the real-time balancing called frequency control. The thesis starts in a description of the situation today, setting up models for the behaviour of hydropower units and the power system relevant to frequency control, and comparing the models with experiments on several hydropower units and on the response of the Nordic grid. It is found that backlash in the regulating mechanisms in hydropower units have a strong impact on the quality of the delivered frequency control. Then, an analysis of what can be done right now to improve frequency control and decrease its costs is made, discussing governor tuning, filters and strategies for allocation of frequency control reserves. The results show that grid frequency quality could be improved considerably by retuning of hydropower governors. However, clear technical requirements and incentives for good frequency control performance are needed. The last part of the thesis concerns the impact from increased electricity production from variable renewable energy sources. The induced balancing need in terms of energy storage volume and balancing power is quantified, and it is found that with large shares of wind power in the system, the energy storage need over the intra-week time horizon is drastically increased. Reduced system inertia due to higher shares of inverter connected production is identified as a problem for the frequency control of the system. A new, linear synthetic inertia concept is suggested to replace the lost inertia and damping. It is shown that continuously active, linear synthetic inertia can improve the frequency quality in normal operation and decrease wear and tear of hydropower units delivering frequency control.

  • Rönnqvist, Carina
    Rönnqvist, Carina
    Församlade svenskar: Etnicitet och religion i Alberta 1898-19502004In: Befolkningshistoriska perspektiv: Festskrift till Lars-Göran Tedebrand / [ed] Redaktionskommitté Anders Brändström, Sören Edvinsson, Tom Ericsson och Peter Sköld, Umeå: Umeå universitet , 2004, 293-317 p.Chapter in book (Other academic)
  • Gatimu, Samwel Maina
    et al.
    Gatimu, Samwel Maina
    Milimo, Benson Williesham
    San Sebastian, Miguel
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Department of Nursing I, University of the Basque country.
    Prevalence and determinants of diabetes among older adults in Ghana2016In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 16, 1174Article in journal (Refereed)
    Abstract [en]

    Background: Diabetes is one of the leading non-communicable diseases in Africa, contributing to the increasing disease burden among the old adults. Thus, the aim of this study was to determine the prevalence and determinants of diabetes among adults aged 50 years and above in Ghana. Methods: A cross sectional study based on data collected from Study of Ageing and Adult Health (SAGE) Wave 1 from 2007 to 2008. Data was collected from 5565 respondents of whom 4135 were aged 50+ years identified using a multistage stratified clusters design. Bivariate and hierarchical multivariable logistic regression models were used to examine the association of the determinants and diabetes. Results: The weighted prevalence of diabetes among the adults aged 50 years and above in Ghana was 3.95% (95% Confidence Interval: 3.35-4.55) with the prevalence being insignificantly higher in females than males (2.16%, 95% CI: 1. 69-2.76 vs. 1.73%, 95% CI: 1.28-2.33). Low level of physical activity (Adjusted Odds Ratio [AOR] 2.11, 95% CI: 1.21-3.69) and obesity (AOR 4.81, 95% CI: 1.92-12.0) were associated with increased odds of diabetes among women while old age (AOR 2.58, 95% CI: 1.29-5.18) and university (AOR 12.8, 95% CI: 4.20-39.1), secondary (AOR 3.61, 95% CI: 1.38-9.47) and primary education (AOR 2.71, 95% CI: 1.02-7.19) were associated with increased the odds of diabetes among men. Conclusion: The prevalence of diabetes among old adults shows a similar trend with that of the general population. However, the prevalence may have been underestimated due to self-reporting and a high rate of undiagnosed diabetes. In addition, the determinants of diabetes among older adults are a clear indication of the need for diabetes prevention programme targeting the young people and that are gender specific to reduce the burden of diabetes at old age. Physical activity and nutrition should be emphasised in any prevention strategy.

  • Aad, G.
    et al.
    Aad, G.
    Bergeås, Elin Kuutmann
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isaksson, Charlie
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Maddocks, Harvey J.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Pelikan, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Measurements of the charge asymmetry in top-quark pair production in the dilepton final state at root s=8 TeV with the ATLAS detector2016In: Physical Review D, ISSN 2470-0010, Vol. 94, no 3, 032006Article in journal (Refereed)
    Abstract [en]

    Measurements of the top-antitop quark pair production charge asymmetry in the dilepton channel, characterized by two high-p(T) leptons (electrons or muons), are presented using data corresponding to an integrated luminosity of 20.3 fb(-1) from pp collisions at a center-of-mass energy root s = 8 TeV collected with the ATLAS detector at the Large Hadron Collider at CERN. Inclusive and differential measurements as a function of the invariant mass, transverse momentum, and longitudinal boost of the tt system arc performed both in the full phase space and in a fiducial phase space closely matching the detector acceptance. Two observables are studied: A(c)(ll) based on the selected leptons and A(c)(tt) based on the reconstructed tt final state. The inclusive asymmetries are measured in the full phase space to be A(c)(ll)= 0.008 +/- 0.006 and A(c)(tt)= 0.021 +/- 0.016, which are in agreement with the Standard Model predictions of A(c)(ll)= 0.0064 +/- 0.0003 and A(c)(tt)= 0.0111 +/- 0.0004.

  • Prim, Mia
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Food and Bioscience, Flavour.
    Prim, Mia
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Food and Bioscience, Flavour.
    Klimatsmart protein: Tenebrio molitor – smaklig, hälsosam och hållbar2016Report (Other academic)
    Abstract [sv]

    Det är ett faktum att vi i västvärlden generellt äter för mycket kött för att det ska vara hållbart för vår hälsa, världens resurser och klimat. Vi behöver alternativa proteinkällor som är mindre hälsovådliga och mer klimatsmarta samt helst har en proteinkvalitet som är likvärdig köttets. Vegetabiliska proteinkällor som baljväxter bör till exempel kompletteras med cerealier för att uppnå fullvärdigt protein samt innehåller ofta ämnen som inhiberar protein- och järnupptag.

    En proteinkälla som presenteras av bland annat FAO (2013) som en framtida lösning på världens behov av klimatsmart protein är insekter. Insekter äts redan i en stor del av världen och utgör där en viktig proteinkälla. Enligt Jansson och Berggren på SLU (2015) finns det potential för insektsproduktion i Sverige av framför allt tre endemiska arter. En av dessa är mjölmasken (Tenebrio molitor) som genom att födas upp på vegetabiliska matrester kan utgöra en hållbar svensk proteinkälla.

    Hållbar är ett adjektiv som används på avsevärt skilda sätt varför en definition behövs för att klargöra vad underliggande rapport innefattar i begreppet.

    En hållbar proteinkälla ska ha en minimal klimatpåverkan och god hälsoinverkan. Produktionen av en hållbar proteinkälla måste vara var kostnads- och resurseffektiv. EFSA (2015) konkluderar att det finns bristande information gällande risker med insektskonsumtion och rekommenderar att forskning initieras för att öka kunskapen om insekter gällande områdena konsumtion, bakterier, virus, parasiter, prioner, allergener, kemikalier, processning och miljö.

  • Public defence: 2017-02-03 13:15 21A342, Karlstad
    Hansson, Rickard
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Physics.
    Hansson, Rickard
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Physics.
    Materials and Device Engineering for Efficient and Stable Polymer Solar Cells2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Polymer solar cells form a promising technology for converting sunlight into electricity, and have reached record efficiencies over 10% and lifetimes of several years. The performance of polymer solar cells depends strongly on the distribution of electron donor and acceptor materials in the active layer. To achieve longer lifetimes, degradation processes in the materials have to be understood. In this thesis, a set of complementary spectroscopy and microscopy techniques, among which soft X-ray techniques have been used to determine the morphology of polymer:fullerene based active layers. We have found that the morphology of TQ1:PC70BM films is strongly influenced by the processing solvent and the use of solvent additives. We have also found, by using soft X-ray techniques, that not only the light-absorbing polymer TQ1, but also the fullerene is susceptible to photo-degradation in air. Moreover, the fullerene degradation is accelerated in the presence of the polymer. Additionally, this thesis addresses the role of the interfacial layers for device performance and stability. The commonly used hole transport material PEDOT:PSS has the advantage of being solution processable at room temperature, but this layer is also known to contribute to the device degradation. We have found that low-temperature processed NiOx is a promising alternative to PEDOT:PSS, leading to improved device performance. Even for encapsulated polymer solar cells, some photo-induced degradation of the electrical performance is observed and is found to depend on the nature of the hole transport material. We found a better initial stability for solar cells with MoO3 hole transport layers than with PEDOT:PSS. In the pursuit of understanding the initial decrease in electrical performance of PEDOT:PSS-based devices, simulations were performed, from which a number of degradation sources could be excluded.

  • Gabrielsson, Linda
    et al.
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Gabrielsson, Linda
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Mattsson, Sofia
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Fowler, Christopher J.
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy2016In: British Journal of Clinical Pharmacology, ISSN 0306-5251, E-ISSN 1365-2125, Vol. 82, no 4, 932-942 p.Article, review/survey (Refereed)
    Abstract [en]

    Palmitoylethanolamide (PEA) has been suggested to have useful analgesic properties and to be devoid of unwanted effects. Here, we have examined critically this contention, and discussed available data concerning the pharmacokinetics of PEA and its formulation. Sixteen clinical trials, six case reports/pilot studies and a meta-analysis of PEA as an analgesic have been published in the literature. For treatment times up to 49days, the current clinical data argue against serious adverse drug reactions (ADRs) at an incidence of 1/200 or greater. For treatment lasting more than 60days, the number of patients is insufficient to rule out a frequency of ADRs of less than 1/100. The six published randomized clinical trials are of variable quality. Presentation of data without information on data spread and nonreporting of data at times other than the final measurement were among issues that were identified. Further, there are no head-to-head clinical comparisons of unmicronized vs. micronized formulations of PEA, and so evidence for superiority of one formulation over the other is currently lacking. Nevertheless, the available clinical data support the contention that PEA has analgesic actions and motivate further study of this compound, particularly with respect to head-to-head comparisons of unmicronized vs. micronized formulations of PEA and comparisons with currently recommended treatments.

  • Lundberg, Anna
    Lundberg, Anna
    De kom till kurhuset: Studier av sociala konsekvenser i kyrkobokföringsmaterialet2004In: Befolkningshistoriska perspektiv: Festskrift till Lars-Göran Tedebrand / [ed] Redaktionskommitté Anders Brändström, Sören Edvinsson, Tom Ericsson och Peter Sköld, Umeå: Umeå universitet , 2004, 161-182 p.Chapter in book (Other academic)
  • Enell, Anja
    et al.
    Enell, Anja
    Lundstedt, Staffan
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Arp, Hans Peter H.
    Josefsson, Sarah
    Cornelissen, Gerard
    Wik, Ola
    Kleja, Dan Berggren
    Combining Leaching and Passive Sampling To Measure the Mobility and Distribution between Porewater, DOC, and Colloids of Native Oxy-PAHs, N-PACs, and PAHs in Historically Contaminated Soil2016In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 50, no 21, 11797-11805 p.Article in journal (Refereed)
    Abstract [en]

    Different methods to quantify soil porewater concentrations of contaminants will provide different types of information. Passive sampling measurements give freely dissolved porewater concentrations (C-pw,C-free), while leaching tests provide information on the mobile concentration (C-pw,C-leach), including contaminants associated with dissolved organic carbon (DOC) and particles/colloids in the porewater. This study presents a novel combination of these two measurements, to study the sorption and mobility of polycyclic aromatic compounds (PACs) to DOC and particulate organic carbon (POC) in 10 historically contaminated soils. The PACs investigated were polycyclic aromatic hydrocarbons (PAHs), oxygenated-PAHs, and nitrogen containing heterocyclic PACs. Observed C-pw,C-leach was up to 5 orders of magnitude higher than C-pw,C-free; implying large biases when C-pw,C-leach is used to assess bioavailability or soil partitioning. Sorption of PACs to DOC and POC was important for the mobility of compounds with log K-OW > 4. Average DOC/water-partitioning coefficients (K-DOC) correlated well with KOW (log K-DOC = 0.89 x log K-OW +1.03 (r(2) = 0.89)). This relationship is likely more accurate for historically contaminated soils than previously published data, which suffer from artifacts caused by problems in measuring C-pw,C-free correctly or not using historically contaminated soils. POC/water-partitioning coefficients (K-POC) were orders of magnitude larger than corresponding K-DOC, suggesting sorption to mobile particles/colloids is the dominant mechanism for PAC mobility.

  • De Samber, Bjorn
    et al.
    De Samber, Bjorn
    Niemiec, Maria J.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Microbial Immunology Research Group, Hans Knöll Institute / Leibniz-Institute for Natural Product Research and Infection Biology, Jena, Germany.
    Laforce, Brecht
    Garrevoet, Jan
    Vergucht, Eva
    De Rycke, Riet
    Cloetens, Peter
    Urban, Constantin F.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
    Vincze, Laszlo
    Probing Intracellular Element Concentration Changes during Neutrophil Extracellular Trap Formation Using Synchrotron Radiation Based X-Ray Fluorescence2016In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 11, e0165604Article in journal (Refereed)
    Abstract [en]

    High pressure frozen (HPF), cryo-substituted microtome sections of 2 mu m thickness containing human neutrophils (white blood cells) were analyzed using synchrotron radiation based X-ray fluorescence (SR nano-XRF) at a spatial resolution of 50 nm. Besides neutrophils from a control culture, we also analyzed neutrophils stimulated for 1-2 h with phorbol myristate acetate (PMA), a substance inducing the formation of so-called Neutrophil Extracellular Traps (or NETs), a defense system again pathogens possibly involving proteins with metal chelating properties. In order to gain insight in metal transport during this process, precise local evaluation of elemental content was performed reaching limits of detection (LODs) of 1 ppb. Mean weight fractions within entire neutrophils, their nuclei and cytoplasms were determined for the three main elements P, S and Cl, but also for the 12 following trace elements: K, Ca, Mn, Fe, Co, Ni, Cu, Zn, Se, Br, Sr and Pb. Statistical analysis, including linear regression provided objective analysis and a measure for concentration changes. The nearly linear Ca and Cl concentration changes in neutrophils could be explained by already known phenomena such as the induction of Ca channels and the uptake of Cl under activation of NET forming neutrophils. Linear concentration changes were also found for P, S, K, Mn, Fe, Co and Se. The observed linear concentration increase for Mn could be related to scavenging of this metal from the pathogen by means of the neutrophil protein calprotectin, whereas the concentration increase of Se may be related to its antioxidant function protecting neutrophils from the reactive oxygen species they produce against pathogens. We emphasize synchrotron radiation based nanoscopic X-ray fluorescence as an enabling analytical technique to study changing (trace) element concentrations throughout cellular processes, provided accurate sample preparation and data-analysis.

  • Marklund, Einar
    et al.
    Swedish Environmental Protection Agency . Executive, Länsstyrelser, Länsstyrelsen Västmanlands län. Botaniska Föreningen i Västmanlands län.
    Marklund, Einar
    Swedish Environmental Protection Agency . Executive, Länsstyrelser, Länsstyrelsen Västmanlands län. Botaniska Föreningen i Västmanlands län.
    Eriksson, Bo
    Botaniska Föreningen i Västmanlands län.
    Floraväkteriet i Västmanlands län 20162016Report (Other academic)
  • Public defence: 2017-01-27 10:15 S205H, Samhällsvetarhuset, Umeå
    Liljenfeldt, Johanna
    Umeå University, Faculty of Social Sciences, Department of Geography and Economic History, Economic and social geography.
    Liljenfeldt, Johanna
    Umeå University, Faculty of Social Sciences, Department of Geography and Economic History, Economic and social geography.
    Where the Wind Blows: the socio-political geography of wind power development in Finland, Norway and Sweden2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis analysis the planning process for large-scale wind power development in Finland, Norway and Sweden. The aim is to explore the emerging power relations and socio-economic dynamics of the negotiation, planning and realization of this new development. The thesis employs an energy justice framework to capture the opportunities different stakeholders have to take part in and influence wind power development processes (‘procedural justice’), and how the potential benefits and burdens of wind power development are divided between stakeholders (‘distributional justice’). The study’s setup is an embedded sequential mixed methods research design, which includes analysis of policy documents, in-dept interviews, observations, as well as register based population data.

    The thesis shows how power relations on both a structural level and an actor level are used to exert power and influence over the planning process for wind power development. On a structural level, the results indicate that transformations in EU directives and national planning laws and guidelines in Finland, Norway and Sweden in recent years have been more focused on speed and efficiency in planning processes than on legitimacy issues. The changes that have been implemented seem to point to diminishing opportunities for broad participation and debate in wind power planning processes, in favour of more top-down processes with a specific, sectoral focus on developing wind power. On the actor level, perceived improper behaviour by different actors within the planning process can further limit the possibilities for participation. People refrain from participating in planning processes, for instance, if they feel that they are treated disrespectfully or if there have occurred procedural errors that undermine the legitimacy of the formal planning process. However, participation in formal planning processes is not the only way to influence planning processes. There are a number of more informal channels, such as using the media or the Internet, lobbying, or rallying local support, that can and have been used by stakeholders to tap into the formal planning process to try to affect its outcomes. Such informal activities have a considerable spatial and scalar reach, the importance of which is that stakeholders utilizing such measures have the possibility to affect not only the local wind power project under debate, but also developments in other places and attitudes towards wind power more generally.

    As concerns distributional issues, the results of the thesis show that the evidence of distributional inequality concerning wind power development on the national scale in Sweden is not very strong; but if such inequalities exist, there are possibilities to redistribute the benefits from wind power to those who are burdened by the developments. Distributional injustice related to wind power development is thus not an evident problem, generally speaking, in Sweden today. However, if this state is to remain, procedural aspects related to the continued development of wind power need to be kept in mind, as procedural and distributional inequalities are intimately related. Of specific concern is the need to address formal and informal procedures that marginalize stakeholder participation in planning processes, but it is equally important to also consider who is to be included in or excluded from negotiations and the distribution of local economic benefits connected to specific wind power projects.

  • Public defence: 2017-02-03 09:00 Föreläsningssal A, Psykiatriska kliniken, Målpunkt F, Plan O, Umeå
    Rajalin, Mia
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
    Rajalin, Mia
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
    Distal risk factors, interpersonal functioning & family skills training in attempted suicide2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Background Suicidal behavior is an important global health problem affecting also significant others. Both genetic and environmental influences play an important role in the development of suicidal behavior. There is a need of interventions for family and friends after a suicide attempt. The aim of this thesis was to assess the impact of family history of suicide (FHS) and early life adversity (ELA) on severity of suicidal behavior and on level of interpersonal problems in suicide attempters. Furthermore it aimed to evaluate a DBT-based skills training program, Family Connections (FC), for relatives and friends of suicide attempters.

    Methods Studies I and II included 181 suicide attempters. FHS was assessed with the Karolinska Self-Harm History Interview or in patient records. ELA was assessed with the Karolinska Interpersonal Violence Scale (KIVS) measuring exposure to interpersonal violence in childhood. Suicide intent was measured with the Freeman scale. Interpersonal problems were assessed with the Inventory of Interpersonal Problems (IIP).

    Study III, a pilot study evaluating the effect of FC for family members of suicide attempters, included 13 participants who completed the program with pre- and post-questionnaires. The experience of burden was assessed with the Burden Assessment Scale (BAS), general wellbeing with Brief Symptom Inventory (BSI) and level of depression was assessed with Beck Depression Inventory (BDI). The Swedish scale Questions About Family Members (QAFM) was used to explore the quality of the participants’ relationship with the patient and the Quality of Life Inventory (QOLI) was used to measure satisfaction with life situation.

    Study IV included 132 family members, and investigated the feasibility and preliminary efficacy of FC in psychiatric care. Participants were assessed pre- and post-intervention with the following self-report questionnaires: BAS, QAFM and Five Facet Mindfulness Questionnaire.

    Results Male suicide attempters with FHS made more serious and well planned suicide attempts and had higher suicide risk. FHS and exposure to interpersonal violence as a child were independent predictors of suicide in male suicide attempters. Regarding interpersonal problems, suicide attempters with FHS had significantly more often an intrusive personal style, indicating that they might have an impaired ability to create stable, long-lasting relationships. In the pilot study the participants reported a significant reduction in burden, an improved psychic health and an improvement in the relationship with the patient after completing FC. In the fourth study, FC showed to be feasible and effectively implemented in a psychiatric outpatient services clinic. Regarding burden, results were in line with the pilot study, with a significant reduction in all subscales in BAS.

    Conclusions High-risk patients call for a consideration of both ELA and FHS in clinical suicide risk assessment. In suicide attempters at biological risk, suicide might be prevented with the early recognition of environmental risks. Further, the interpersonal problems associated with FHS may cause difficulties for suicide attempters to accept or benefit from treatment, and caregivers should take into account the characteristics of the suicide attempter´s interpersonal functioning. The results from the pilot study provide support for the need and importance of an educational program addressed specifically to family members of suicide attempters. Preliminary results support the feasibility and potential value of an implementation of FC in psychiatric open care clinics.

  • Public defence: 2017-01-27 09:00 N200, Naturvetarhuset, Umeå
    Ekestubbe, Sofie
    Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
    Ekestubbe, Sofie
    Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
    Timing and targeting of Type III secretion translocation of virulence effectors in Yersinia2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The Type III secretion system (T3SS) is an important virulence mechanism that allows pathogenic bacteria to translocate virulence effectors directly into the cytoplasm of eukaryotic host cells to manipulate the host cells in favor of the pathogen. Enteropathogenic Yersinia pseudotuberculosis use a T3SS to translocate effectors, Yops, that prevent phagocytosis by immune cells, and is largely dependent on it to establish and sustain an infection in the lymphoid tissues of a mammalian host. Translocation into a host cell requires specific translocator proteins, and is tightly controlled from both the bacterial and host cell cytoplasm. We aimed to investigate two of the regulatory elements, YopN and LcrV, to gain more insight into the translocation mechanism. Two separate regulatory complexes regulate expression and secretion of Yops, however, the processes are linked so that expression is induced when secretion is activated. A complex, including YopD, prevents expression of Yops, while YopN-TyeA and LcrG block secretion. LcrV is required to relieve the secretion block, by sequestering LcrG. We verified that LcrG binds to the C-terminal part of LcrV, which is consistent with what has been shown in Y. pestis. In addition to their regulatory roles, both LcrV and YopD are translocators and are assumed to interact at the bacterial surface, where LcrV promotes insertion of YopB and YopD into the host cell membrane. However, here we show that purified YopD failed to interact with LcrV, instead YopD solely interacted with a complex of LcrV-LcrG. This indicates that LcrV and YopD interact in the bacterial cytosol, which may be important for regulation of Yop expression and secretion. The established role of YopN is to block secretion prior to host cell contact. We found that deleting the central region (amino acids 76-181) had no effect on the regulatory role of YopN in expression and secretion of Yops. Interestingly, we found that, even though the YopN∆76-181 mutant secreted the translocators with similar kinetics as the wild type strain, translocation of the effector YopH, into HeLa cells, was significantly reduced. Consequently, the YopN∆76-181 mutant was unable to block phagocytosis, almost to the same level as the ∆lcrV mutant which is completely unable to translocate YopH. Our results indicate that YopN is involved in the translocation step in addition to its role in regulating secretion. Further, we show that the amino terminal of LcrV, in the context of translocation, is involved in the early intracellular targeting of YopH in order to block phagocytosis efficiently and sustain an in vivo infection. LcrV mutants that failed to efficiently target YopH intracellularly were severely attenuated also for in vivo virulence. All together, we show that LcrV and YopN are involved in more steps in the regulation of translocation, than what was known before. Our studies also highlight that early translocation is essential for Yersinia to block phagocytosis, which in the end is essential for in vivo virulence.

  • Public defence: 2017-02-03 10:00 Stora hörsalen (KB.E3.03), Umeå
    Berg, Lotta
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Berg, Lotta
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. The research presented in this thesis is based on studies of acetylcholinesterase (AChE). AChE is an essential enzyme with the important function of terminating neurotransmission at cholinergic synapses. AChE is also the target of a range of biologically active molecules including drugs, pesticides, and poisons. Due to the molecular and the functional characteristics of the enzyme, it offers both challenges and possibilities for investigating protein-ligand interactions. In the thesis, complexes between AChE and drug-like ligands have been studied in detail by a combination of experimental techniques and theoretical methods. The studies provided insight into the non-covalent interactions formed between AChE and ligands, where non-classical CH∙∙∙Y hydrogen bonds (Y = O or arene) were found to be common and important. The non-classical hydrogen bonds were characterized by density functional theory calculations that revealed features that may provide unexplored possibilities in for example structure-based design. Moreover, the study of two enantiomeric inhibitors of AChE provided important insight into the structural basis of enthalpy-entropy compensation. As part of the research, available computational methods have been evaluated and new approaches have been developed. This resulted in a methodology that allowed detailed analysis of the AChE-ligand complexes. Moreover, the methodology also proved to be a useful tool in the refinement of X-ray crystallographic data. This was demonstrated by the determination of a prereaction conformation of the complex between the nerve-agent antidote HI-6 and AChE inhibited by the nerve agent sarin. The structure of the ternary complex constitutes an important contribution of relevance for the design of new and improved drugs for treatment of nerve-agent poisoning. The research presented in the thesis has contributed to the knowledge of AChE and also has implications for drug discovery and the understanding of biochemical processes in general.

  • Russmann, Uta
    et al.
    FHWien WKW Univ Appl Sci Management & Commun, Dept Commun Mkt & Sales, A-1180 Vienna, Austria..
    Russmann, Uta
    FHWien WKW Univ Appl Sci Management & Commun, Dept Commun Mkt & Sales, A-1180 Vienna, Austria..
    Svensson, Jakob
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Studying Organizations on Instagram2016In: Information Science and Technology, ISSN 2078-2489, E-ISSN 2078-2489, Vol. 7, no 4, 58Article in journal (Refereed)
    Abstract [en]

    With the rise of social media platforms based on the sharing of pictures and videos, the question of how such platforms should be studied arises. Previous research on social media (content) has mainly focused on text (written words) and the rather text-based social media platforms Twitter and Facebook. Drawing on research in the fields of visual, political, and business communication, we introduce a methodological framework to study the fast-growing image-sharing service Instagram. This methodological framework was developed to study political parties' Instagram accounts and tested by means of a study of Swedish political parties during the 2014 election campaign. In this article, we adapt the framework to also study other types of organizations active on Instagram by focusing on the following main questions: Do organizations only use Instagram to share one-way information, focusing on disseminating information and self-presentation? Or is Instagram used for two-way communication to establish and cultivate organization-public relationships? We introduce and discuss the coding of variables with respect to four clusters: the perception of the posting, image management, integration, and interactivity.

  • Fujimoto, Toyoshi
    et al.
    Fujimoto, Toyoshi
    Parmryd, Ingela
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Interleaflet Coupling, Pinning, and Leaflet Asymmetry—Major Players in Plasma Membrane Nanodomain Formation2016In: Frontiers in Cell and Developmental Biology, ISSN 2296-634X, Vol. 4, 155Article, review/survey (Refereed)
    Abstract [en]

    The plasma membrane has a highly asymmetric distribution of lipids and contains dynamic nanodomains many of which are liquid entities surrounded by a second, slightly different, liquid environment. Contributing to the dynamics is a continuous repartitioning of components between the two types of liquids and transient links between lipids and proteins, both to extracellular matrix and cytoplasmic components, that temporarily pin membrane constituents. This make plasma membrane nanodomains exceptionally challenging to study and much of what is known about membrane domains has been deduced from studies on model membranes at equilibrium. However, living cells are by definition not at equilibrium and lipids are distributed asymmetrically with inositol phospholipids, phosphatidylethanolamines and phosphatidylserines confined mostly to the inner leaflet and glyco- and sphingolipids to the outer leaflet. Moreover, each phospholipid group encompasses a wealth of species with different acyl chain combinations whose lateral distribution is heterogeneous. It is becoming increasingly clear that asymmetry and pinning play important roles in plasma membrane nanodomain formation and coupling between the two lipid monolayers. How asymmetry, pinning, and interdigitation contribute to the plasma membrane organization is only beginning to be unraveled and here we discuss their roles and interdependence.

  • Sandberg, Erik
    et al.
    Linköping University, Department of Management and Engineering, Logistics & Quality Management. Linköping University, Faculty of Science & Engineering.
    Sandberg, Erik
    Linköping University, Department of Management and Engineering, Logistics & Quality Management. Linköping University, Faculty of Science & Engineering.
    Abrahamsson, Mats
    Linköping University, Department of Management and Engineering, Logistics & Quality Management. Linköping University, Faculty of Science & Engineering.
    Flödesorientering av globalt inköpsarbete2016Report (Other academic)
    Abstract [sv]

    Under senare år har globalt inköp fått en allt större strategisk betydelse för svenska handelsföretag. Tidigare forskning har visat att globalt inköpsarbete kan vara en avgörande konkurrensfördel, samtidigt som det innebär stora utmaningar. För at t framgångsrikt utnyttja globalt inköp som en konkurrensfördel behöver svenska handelsföretag bli mer flödesorienterade. Försörjningskedjans resurser som helhet, och inte bara företagets egna, behöver utnyttjas för att kunna skapa konkurrenskraft. Med bakgrund i det faktum att leveransförmågan och därmed kundservicen aldrig blir bättre än vad varuförsörjningen tillåter, spelar organiseringen av det globala inköpet en avgörande roll.

    Syftet med projektet är att öka förståelsen för hur svenska handelsföretag ska organisera sitt globala inköpsarbete för en högre grad av flödesorientering.

    Inom ramen för forskningsprojektet har forskningsfrågor adresserats om:

    1. parametrar för valet av inköpsregion och specifik leverantör,
    2. det fysiska flödet av produkter, samt
    3. organisationsformer för globalt inköp.

    Teoretiskt har projektet tagit utgångspunkt i litteratur om globalt inköp, flödesorientering och så kallad paradoxteori. Projektets empiriska bas är två fallstudier (Hultafors Group AB:s division för arbetskläder, Snickers, och Indiska Magasinet AB), samt en enkätstudie bland inköpschefer på svenska handelsföretag. Totalt har sju konferenspapper, ett journalpapper och två populärvetenskapliga artiklar författats inom ramen för projektet. Dessa är projektets huvudsakliga leverabler som alla på olika sätt bidrar till att besvara projektets syfte och forskningsfrågor. Den här rapporten är en populärvetenskaplig sammanfattning av forskningsprojektet.

    Resultaten visar att kostnader, service, ledtider, såväl som miljö- och CSR-relaterade parametrar spelar en viktig roll vid valet av region och specifik leverantör. Framförallt är det totalkostnaden (pris och någon form av ”hemtagningskostnad”) och ledtider som är de mest avgörande parametrarna. Miljö- och CSR-relaterade aspekter anses ha mindre betydelse. Paradoxperspektivet visar på behovet av att balansera prestationsmått gentemot varandra. Vid utvärderingar av en ny leverantör eller en ny leverantörsregion är det viktigt att ta hänsyn till ett brett spektrum av olika kriterier. För det fysiska flödet finns möjligheter till att konsolidera flödet till noder i Asien och/eller Europa. Studien visar att olika alternativ finns, och att det också finns alternativ till transportslaget båt, som idag dominerar på grund av förhållandevis låga transportkostnader. Dessa alternativ kan bli mycket intressanta i de fall där ledtiderna behöver kortas. För utformningen av en global inköpsorganisation visar våra resultat att tre av de mest tydliga parametrarna som är viktiga att förstå och analysera är:

    1. graden av vertikal integration, det vill säga i vilken utsträckning som handelsföretaget bör äga aktörer uppströms i försörjningskedjan,
    2. graden av ansvarstagande för försörjningskedjans prestation, det vill säga hela försörjningskedjans prestationer gentemot slutkunderna, samt
    3. graden av ömsesidigt, långsiktigt samarbete, det vill säga där företaget tillsammans med andra aktörer i försörjningskedjan utvecklar försörjningskedjans prestationer.

    För praktiker bidrar resultaten från detta projekt med nya insikter och perspektiv på hur företag bör tänka kring sin organisation av det globala inköpet. De ska fungera som en katalysator och inspiration för svenska handelsföretag som vill utveckla sin konkurrenskraft med hjälp av sitt globala inköp. Forskningsmässigt är globalt inköp i handelsföretag ett område som också fortsättningsvis är i behov av ny kunskap och utveckling. Den roll och betydelse som inköpsorganisationen har för konkurrenskraften förändras hela tiden och lär fortsätta göra det. Den snabba utvecklingen gör också att forskningen behöver hänga med: globalt inköp som forskningsobjekt behöver ständigt belysas med hjälp av nya teoretiska perspektiv och gamla sanningar behöver kontinuerligt utmanas och ifrågasättas. Ju mer global konkurrens inom handeln, desto viktigare blir frågan om hur det globala inköpet ska utformas.

  • Landstedt, Evelina
    et al.
    Umea Univ, Dept Publ Hlth & Clincial Med Epidemiol & Global, Umea, Sweden..
    Landstedt, Evelina
    Umea Univ, Dept Publ Hlth & Clincial Med Epidemiol & Global, Umea, Sweden..
    Brydsten, Anna
    Umea Univ, Dept Publ Hlth & Clincial Med Epidemiol & Global, Umea, Sweden..
    Hammarström, Anne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. Umea Univ, Dept Publ Hlth & Clincial Med Epidemiol & Global, Umea, Sweden..
    Virtanen, Pekka
    Univ Tampere, Sch Hlth Sci, Tampere, Finland..
    Almquist, Ylva B.
    Stockholm Univ, Karolinska Inst, Ctr Hlth Equ Studies CHESS, Stockholm, Sweden..
    The role of social position and depressive symptoms in adolescence for life-course trajectories of education and work: a cohort study2016In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 16, 1169Article in journal (Refereed)
    Abstract [en]

    Background: While a vast amount of studies confirm the social reproduction of class and status from one generation to the next, less is known about the role of health in the child generation for these processes. Research has shown that particularly mental distress in adolescence is important for future life chances. This study aimed to examine the importance of parental socioeconomic position and depressive symptoms in youth for life-course trajectories of education and labour market attachment among men and women. Methods: Based on four waves of questionnaire data from the Northern Swedish Cohort (n = 1,001), consisting of individuals born in 1965, three steps of gender-separate analyses were undertaken. First, the individual trajectories of education and labour market attachment from age 18 to 42 were mapped through sequence analysis. Second, cluster analysis was used to identify typical trajectories. Third, two indicators of parental socioeconomic position - occupational class and employment status - and depressive symptoms at age 16 were used in multinomial regression analyses to predict adult life-course trajectories. Results: Four typical trajectories were identified for men, of which three were characterised by stable employment and various lengths of education, and the fourth reflected a more unstable situation. Among women, five trajectories emerged, characterised by more instability compared to men. Low parental occupational class and unemployment were significantly associated with a higher risk of ending up in less advantaged trajectories for men while, for women, this was only the case for occupational class. Youth levels of depressive symptoms did not significantly differ across the trajectories. Conclusions: This study found support for the intergenerational reproduction of social position, particularly when measured in terms of parental occupational class. Youth depressive symptoms did not show clear differences across types of trajectories, subsequently impeding such symptoms to trigger any selection processes. While this could be a consequence of the specific framework of the current study, it may also suggest that depressive symptoms in youth are not a root cause for the more complex processes through which how social position develops across life. The possible impact of welfare and labour market policies is discussed.

  • Hök, Jöran
    Södertörn University, School of Social Sciences, Journalism.
    Hök, Jöran
    Södertörn University, School of Social Sciences, Journalism.
    Konfliktjournalistik i demokratiskaoch auktoritära stater2016In: Ukraina och informationskriget: Journalistik mellan ideal och självcensur / [ed] Gunnar Nygren, Jöran Hök, Karlstad: Myndigheten för samhällsskydd och beredskap (MSB) , 2016, 33-58 p.Chapter in book (Other academic)
  • Nygren, Gunnar
    et al.
    Södertörn University, School of Social Sciences, Journalism.
    Nygren, Gunnar
    Södertörn University, School of Social Sciences, Journalism.
    Hök, Jöran
    Södertörn University, School of Social Sciences, Journalism.
    Vänner och fiender i mediebilder av Ukrainakriget2016In: Ukraina och informationskriget: Journalistik mellan ideal och självcensur / [ed] Gunnar Nygren, Jöran Hök, Karlstad: Myndigheten för samhällsskydd och beredskap (MSB) , 2016, 243-267 p.Chapter in book (Other academic)
  • Nygren, Gunnar
    Södertörn University, School of Social Sciences, Journalism.
    Nygren, Gunnar
    Södertörn University, School of Social Sciences, Journalism.
    Vilseledning och förfalskning – desinformation som vapen2016In: Ukraina och informationskriget: Journalistik mellan ideal och självcensur / [ed] Gunnar Nygren, Jöran Hök, Karlstad: Myndigheten för samhällsskydd och beredskap (MSB) , 2016, 223-240 p.Chapter in book (Other academic)
  • Nygren, Gunnar
    Södertörn University, School of Social Sciences, Journalism.
    Nygren, Gunnar
    Södertörn University, School of Social Sciences, Journalism.
    Sverige: Geopolitik och en mänsklig vinkel2016In: Ukraina och informationskriget: Journalistik mellan ideal och självcensur / [ed] Gunnar Nygren, Jöran Hök, Karlstad: Myndigheten för samhällsskydd och beredskap (MSB) , 2016, 161-189 p.Chapter in book (Other academic)
  • Cortese, Giuliana
    et al.
    Univ Padua, Dept Stat Sci, Padua, Italy..
    Cortese, Giuliana
    Univ Padua, Dept Stat Sci, Padua, Italy..
    Gandasi, Nikhil R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Barge, Sebastian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Pedersen, Morten Gram
    Univ Padua, Dept Informat Engn, Padua, Italy..
    Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells2016In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 12, e0167282Article in journal (Refereed)
    Abstract [en]

    Hormones and neurotransmitters are released when secretory granules or synaptic vesicles fuse with the cell membrane, a process denoted exocytosis. Modern imaging techniques, in particular total internal reflection fluorescence (TIRF) microscopy, allow the investigator to monitor secretory granules at the plasma membrane before and when they undergo exocytosis. However, rigorous statistical approaches for temporal analysis of such exocytosis data are still lacking. We propose here that statistical methods from time-to-event (also known as survival) analysis are well suited for the problem. These methods are typically used in clinical settings when individuals are followed over time to the occurrence of an event such as death, remission or conception. We model the rate of exocytosis in response to pulses of stimuli in insulin-secreting pancreatic beta-cell from healthy and diabetic human donors using piecewise-constant hazard modeling. To study heterogeneity in the granule population we exploit frailty modeling, which describe unobserved differences in the propensity to exocytosis. In particular, we insert a discrete frailty in our statistical model to account for the higher rate of exocytosis in an immediately releasable pool (IRP) of insulin-containing granules. Estimates of parameters are obtained from maximum-likelihood methods. Since granules within the same cell are correlated, i.e., the data are clustered, a modified likelihood function is used for log-likelihood ratio tests in order to perform valid inference. Our approach allows us for example to estimate the size of the IRP in the cells, and we find that the IRP is deficient in diabetic cells. This novel application of time-to-event analysis and frailty modeling should be useful also for the study of other well-defined temporal events at the cellular level.

  • Nygren, Gunnar
    Södertörn University, School of Social Sciences, Journalism.
    Nygren, Gunnar
    Södertörn University, School of Social Sciences, Journalism.
    Informationskrig – mediekontroll och journalistik2016In: Ukraina och informationskriget: Journalistik mellan ideal och självcensur / [ed] Gunnar Nygren, Jöran Hök, Karlstad: Myndigheten för samhällsskydd och beredskap (MSB) , 2016, 17-30 p.Chapter in book (Other academic)
  • Gardeström, Elin
    Södertörn University, School of Social Sciences, Journalism.
    Gardeström, Elin
    Södertörn University, School of Social Sciences, Journalism.
    Educating Journalists: The Who, When, How, and Why of Early Journalism Programmes in the Nordic Countries2016In: Becoming a Journalist: Journalism Education in the Nordic Countries / [ed] Nygren, Hovden & Zilliacus-Tikkanen, Göteborg: Nordicom, 2016, 25-37 p.Chapter in book (Other academic)
    Abstract [en]

    This article compares systems of journalism education in the Nordic countries, focusing on how education programmes for journalists first emerged. The theoretical perspectiveof the sociology of journalism education used by sociologist Margaret Archer, who viewsnational educational systems as always being shaped through a struggle between interest groups. The questions are when education programmes for journalists were founded, who initiated them and how the process of founding schools and programmes progressed. In addition to these questions, the article discusses the emergence of journalism educationin relation to the party press system and to the process of professionalisation. Theres pective developments of journalism education in the Nordic countries emerged in similar patterns. The apprentice system was, at first, combined with short courses arranged by press organisations, and then step-by-step replaced by journalism schools. In this process, the press organisations lost control over journalism education, even if theytried to maintain control through independent schools or through cooperation with universities. The mix of subjects in the journalist training curriculum has been discussedin all countries, centred on the balance between theoretical and vocational subjects.

  • Quentmeier, Hilmar
    et al.
    Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany..
    Quentmeier, Hilmar
    Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany..
    Drexler, Hans G.
    Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany..
    Hauer, Vivien
    Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany..
    MacLeod, Roderick A. F.
    Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany..
    Pommerenke, Claudia
    Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany..
    Uphoff, Cord C.
    Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany..
    Zaborski, Margarete
    Leibniz Inst DSMZ German Collect Microorganisms &, Dept Human & Anim Cell Lines, Braunschweig, Germany..
    Berglund, Mattias
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. Univ Uppsala Hosp, Uppsala, Sweden..
    Enblad, Gunilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. Univ Uppsala Hosp, Uppsala, Sweden..
    Amini, Rose-Marie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. Univ Uppsala Hosp, Uppsala, Sweden..
    Diffuse Large B Cell Lymphoma Cell Line U2946: Model for MCL1 Inhibitor Testing2016In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 12, e0167599Article in journal (Refereed)
    Abstract [en]

    Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma worldwide. We describe the establishment and molecular characteristics of the DLBCL cell line U-2946. This cell line was derived from a 52-year-old male with DLBCL. U-2946 cells carried the chromosomal translocation t(8; 14) and strongly expressed MYC, but not the mature B-cell lymphoma associated oncogenes BCL2 and BCL6. Instead, U-2946 cells expressed the antiapoptotic BCL2 family member MCL1 which was highly amplified genomically (14n). MCL1 amplification is recurrent in DLBCL, especially in the activated B cell (ABC) variant. Results of microarray expression cluster analysis placed U-2946 together with ABC-, but apart from germinal center (GC)-type DLBCL cell lines. The 1q21.3 region including MCL1 was focally coamplified with a short region of 17p11.2 (also present at 14n). The MCL1 inhibitor A-1210477 triggered apoptosis in U-2946 (MCL1(pos)/BCL2(neg)) cells. In contrast to BCL2(pos) DLBCL cell lines, U-2946 did not respond to the BCL2 inhibitor ABT-263. In conclusion, the novel characteristics of cell line U-2946 renders it a unique model system to test the function of small molecule inhibitors, especially when constructing a panel of DLBCL cell lines expressing broad combinations of antiapoptotic BCL2-family members.