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  • Carrasquilla, German D.
    et al.
    Frumento, Paolo
    Berglund, Anita
    Borgfeldt, Christer
    Bottai, Matteo
    Chiavenna, Chiara
    Eliasson, Mats
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Engström, Gunnar
    Hallmans, Göran
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Jansson, Jan-Håkan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Magnusson, Patrik K.
    Nilsson, Peter M.
    Pedersen, Nancy L.
    Wolk, Alicja
    Leander, Karin
    Postmenopausal hormone therapy and risk of stroke: A pooled analysis of data from population-based cohort studies2017In: PLoS Medicine, ISSN 1549-1277, E-ISSN 1549-1676, Vol. 14, no 11, e1002445Article in journal (Refereed)
    Abstract [en]

    Background: Recent research indicates a favourable influence of postmenopausal hormone therapy (HT) if initiated early, but not late, on subclinical atherosclerosis. However, the clinical relevance of timing of HT initiation for hard end points such as stroke remains to be determined. Further, no previous research has considered the timing of initiation of HT in relation to haemorrhagic stroke risk. The importance of the route of administration, type, active ingredient, and duration of HT for stroke risk is also unclear. We aimed to assess the association between HT and risk of stroke, considering the timing of initiation, route of administration, type, active ingredient, and duration of HT.

    Methods and findings: Data on HT use reported by the participants in 5 population-based Swedish cohort studies, with baseline investigations performed during the period 1987-2002, were combined in this observational study. In total, 88,914 postmenopausal women who reported data on HT use and had no previous cardiovascular disease diagnosis were included. Incident events of stroke (ischaemic, haemorrhagic, or unspecified) and haemorrhagic stroke were identified from national population registers. Laplace regression was employed to assess crude and multivariable-adjusted associations between HT and stroke risk by estimating percentile differences (PDs) with 95% confidence intervals (CIs). The fifth and first PDs were calculated for stroke and haemorrhagic stroke, respectively. Crude models were adjusted for age at baseline only. The final adjusted models included age at baseline, level of education, smoking status, body mass index, level of physical activity, and age at menopause onset. Additional variables evaluated for potential confounding were type of menopause, parity, use of oral contraceptives, alcohol consumption, hypertension, dyslipidaemia, diabetes, family history of cardiovascular disease, and cohort. During a median follow-up of 14.3 years, 6,371 first-time stroke events were recorded; of these, 1,080 were haemorrhagic. Following multivariable adjustment, early initiation (<5 years since menopause onset) of HT was associated with a longer stroke-free period than never use (fifth PD, 1.00 years; 95% CI 0.42 to 1.57), but there was no significant extension to the time period free of haemorrhagic stroke (first PD, 1.52 years; 95% CI -0.32 to 3.37). When considering timing as a continuous variable, the stroke-free and the haemorrhagic stroke-free periods were maximal if HT was initiated approximately 0-5 years from the onset of menopause. If single conjugated equine oestrogen HT was used, late initiation of HT was associated with a shorter stroke-free (fifth PD, -4.41 years; 95% CI -7.14 to -1.68) and haemorrhagic stroke-free (first PD, -9.51 years; 95% CI -12.77 to -6.24) period than never use. Combined HT when initiated late was significantly associated with a shorter haemorrhagic stroke-free period (first PD, -1.97 years; 95% CI -3.81 to -0.13), but not with a shorter stroke-free period (fifth PD, -1.21 years; 95% CI -3.11 to 0.68) than never use. Given the observational nature of this study, the possibility of uncontrolled confounding cannot be excluded. Further, immortal time bias, also related to the observational design, cannot be ruled out.

    Conclusions: When initiated early in relation to menopause onset, HT was not associated with increased risk of incident stroke, regardless of the route of administration, type of HT, active ingredient, and duration. Generally, these findings held also for haemorrhagic stroke. Our results suggest that the initiation of HT 0-5 years after menopause onset, as compared to never use, is associated with a decreased risk of stroke and haemorrhagic stroke. Late initiation was associated with elevated risks of stroke and haemorrhagic stroke when conjugated equine oestrogen was used as single therapy. Late initiation of combined HT was associated with haemorrhagic stroke risk.

  • Jansson, Andreas
    et al.
    Swedish National Road and Transport Research Institute, Traffic and road users, Driving Simulation and Visualization.
    Ahlström, Christer
    Swedish National Road and Transport Research Institute, Traffic and road users, Human Factors in the Transport System.
    Linking gaze tracking with a simulated world2017Report (Other academic)
    Abstract [en]

    The main focus of this study was to develop a software able to link eye tracking data to simulator data, making it possible to automatically detect what the driver is looking at in the simulated world. This was achieved by merging data from a SmartEye system with data from the simulator. Thereby realtime visualisation of where the driver is looking is facilitated, and what the driver is targeting can be shown to the test leader to trigger events in the scenarios, etc. This also facilitates automatic gaze annotations that can be used in subsequent analyses when studying visual behaviour.

    The developed software, VIMSI, is responsible for collecting eye tracking data from SmartEye, filter and aggregate this data with data from the simulation and then send processed data to the graphics to visualize the result. The software was tested in one of VTI’s driving simulators. This initial testing of VIMSI showed that the software is capable of visualising what the driver is looking at in real time. The software also makes it possible to log data from the test drives which can be useful when studying driver behaviour. To improve the functionality of VIMSI, it is necessary to consider using UDP instead of IPC when directing data from the VIMSI software to the graphics engine VISIR. This will enable the use of another software, ScenarioReplay, developed at VTI for replaying test drives. A proper configuration and calibration of the SmartEye cameras is necessary to achieve high quality of the data from the SmartEye Pro software, which is a precondition for VIMSI.

  • Aléx, Jonas
    et al.
    Umeå University, Faculty of Medicine, Department of Nursing. Umeå University, Arctic Research Centre at Umeå University.
    Uppstu, Tom
    Umeå University, Faculty of Medicine, Department of Nursing.
    Saveman, Britt-Inger
    Umeå University, Arctic Research Centre at Umeå University. Umeå University, Faculty of Medicine, Department of Nursing.
    The opinions of ambulance personnel regarding using a heated mattress for patients being cared for in a cold climate - An intervention study in ambulance care2017In: International Journal of Circumpolar Health, ISSN 1239-9736, E-ISSN 2242-3982, Vol. 76, 1379305Article in journal (Refereed)
    Abstract [en]

    The purpose of the study was to describe the opinions of ambulance personnel regarding differences between using a heated mattress and a standard ambulance mattress. This study was an intervention study with pre- and post-evaluation. Evaluations of the opinions of personnel regarding the standard unheated mattress were conducted initially. After the intervention with new heated mattresses, follow-up evaluations were conducted. Ambulance personnel (n=64) from an ambulance station in northern Sweden took part in the study, which ran from October 2014 until February 2016. There were differences in opinions regarding the standard unheated mattress and the new heated mattress. The evaluation of the proxy ratings by the personnel showed that the heated mattress was warmer than the standard mattress, more pleasant to lie on and that patients were happier and more relaxed than when the standard mattress was used. The ambulance personnel in this study rated the experience of working with the heated mattress as very positive and proxy rated that it had a good effect on patient comfort. A heated mattress can be recommended for patients in ambulance care, even if more research is needed to receive sufficient evidence.

  • Public defence: 2018-01-26 12:24 Baertlingsalen, Halmstad
    Franck, Alina
    Linnaeus University, Faculty of Health and Life Sciences, Department of Psychology.
    The junior-to-senior transition in Swedish athletes: A longitudinal study2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This dissertation project was an exploration of junior-to-senior transition (JST) processes in Swedish sport club athletes based on holistic, developmental, and ecological perspectives. It consists of two multi-level studies covered by four separate articles. The first study is a quantitative longitudinal investigation of athletes’ transitional and personal variables during a two-and-a-half-year period including five measurements times (N = 101). The second study is a qualitative exploration of the JST pathways of four athletes who were also participants of the first study; the athletes’ transition narratives could be related to the previously discovered dynamics of their JSTs.

         The first article (1a), presenting study 1, is focused on identifying profiles of athletes in the JST based on some of their personal characteristics (athletic identity, self-esteem, and goal orientation) followed by a description of the JST pathways relevant to their profiles. The latent profile analysis resulted in three athlete profiles. Athletic identity appeared to be a key personal characteristic that influenced the dynamics of the JST adjustment. Different styles of coping strategies were also associated with different JST pathways.

         The second article (1b), presenting study 1, is aimed at identifying adjustment patterns in the JST based on athletes’ dynamics of adjustment during a two-and-a-half-year period, and describes the athletes’ demographics, personal and transitional characteristics at the beginning of the JSTs that were related to the different adjustment patterns. The latent profile analysis on athletes’ perceived degree of adjustment provided three profiles with different adjustment patterns (i.e., progressive, regressive, sustainable). Further analyses (descriptive statistics and Cohen’s d) showed that keeping a primary focus on sport (without ignoring other spheres of life), having a strong athletic identity, and a high motivation to reach the senior level were (to different degrees) relevant for both progressive and sustainable adjustment patterns.

         The first article (2a), presenting study 2, qualitatively explores two individual sport athletes’ (a male swimmer and a female tennis player) JST transition pathways, emphasising psychosocial factors that were perceived as facilitating and debilitating for the transition process. Narrative type interviews were used, and the holistic-form structural analysis provided a central storyline – a performance narrative – that was common for both athletes and two individual side storylines that were the swimmer’s effort and relationship narrative and the tennis player’s injury and reorientation narrative. Both athletes experienced various crossroads and shared perceptions of the factors facilitating coping (e.g., family, some coaches, elite sport club environment), but their reflections on the debilitating psychosocial factors of their JSTs were more individualistic than their views on the facilitating factors..

         The second article (2b), presenting study 2, has the same objectives and the same methodology as article 2a, but focuses on two team sport athletes’ (a male football player and a female basketball player) JST pathways. The football player’s JST path developed into a performance and family narrative, and the basketball player’s reflections on the transition process formed an enjoyment and relationship narrative. The players’ JST paths were lined with different crossroads, and throughout the transitions they perceived the key facilitating persons to be their families (e.g., parents, grandparents, siblings) and teammates, but some of the coaches’ behaviors were perceived as debilitating factors.

    Major contributions to knowledge in this dissertation project include: (a) considering the JST (longitudinally) as a process involving dynamics and interactions of the transition demands, coping strategies, personal and environmental resources, and barriers influencing the JST outcome; (b) supporting the athletic career transition model in combination with the holistic, developmental, and ecological perspectives as adequate frameworks to study the JST; (c) suggesting that the integrated JST framework supported by the empirical findings can be used in the future research; (d) demonstrating significant variations in the JST pathways and adjustment patterns on the sub-group level (study 1) and also on the individual level (study 2); and (e) providing context-specific recommendations for different levels of the Swedish sport system for optimizing Swedish sport club athletes’ JSTs and supporting their continued sport participation on either the senior elite or the recreational level.

  • Christiansson, Magnus
    Swedish Defence University, Department of Security, Strategy and Leadership (ISSL), Division of Strategy.
    The NATO question in Sweden under the Trump presidency: Military non-alignment between power politics and feminist foreign policy2017In: Finland, Sweden & NATO: Did Trump Change Everything? / [ed] Jaan Siitonen, Helsingfors: Svenska Bildningsförbundet , 2017, 39-56 p.Chapter in book (Other (popular science, discussion, etc.))
  • NOMESCO, Nomesco
    Nordic Council of Ministers, NOMESCO-NOSOSCO.
    Drug related deaths in the Nordic countries: Revision of the statistical definition2017 (ed. 1)Book (Other academic)
    Abstract [en]

    Recently the official statistics describing drug related deaths in Sweden werescrutinised. One of the most important findings was that statistical trend data ofdrug related deaths in Sweden was not comparable over time. The main reasonsbehind this being changes in coding practices and in methods used in forensicchemistry. As a result the national Swedish index was revised. It is within thatcontext the revision of the NOMESCO-index should be seen.In the process of investigating the topic at hand other related issues has emerged,such as the definition of the present index and the implementation of the same.

  • Lundström, Maria
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Leino, Matti W.
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering. Nordiska museet, Swedish Museum of Cultural History, Stockholm, Sweden; 3The Archaeological Research Laboratory, Department of Archaeology and Classical Studies, Stockholm University, Stockholm, Sweden.
    Hagenblad, Jenny
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Evolutionary history of the NAM-B1 gene in wild and domesticated tetraploid wheat2017In: BMC Genetics, ISSN 1471-2156, E-ISSN 1471-2156, Vol. 18, 118Article in journal (Refereed)
    Abstract [en]

    Background

    The NAM-B1 gene in wheat has for almost three decades been extensively studied and utilized in breeding programs because of its significant impact on grain protein and mineral content and pleiotropic effects on senescence rate and grain size. First detected in wild emmer wheat, the wild-type allele of the gene has been introgressed into durum and bread wheat. Later studies have, however, also found the presence of the wild-type allele in some domesticated subspecies. In this study we trace the evolutionary history of the NAM-B1 in tetraploid wheat species and evaluate it as a putative domestication gene.

    Results

    Genotyping of wild and landrace tetraploid accessions showed presence of only null alleles in durum. Domesticated emmer wheats contained both null alleles and the wild-type allele while wild emmers, with one exception, only carried the wild-type allele. One of the null alleles consists of a deletion that covers several 100 kb. The other null-allele, a one-basepair frame-shift insertion, likely arose among wild emmer. This allele was the target of a selective sweep, extending over several 100 kb.

    Conclusions

    The NAM-B1 gene fulfils some criteria for being a domestication gene by encoding a trait of domestication relevance (seed size) and is here shown to have been under positive selection. The presence of both wild-type and null alleles in domesticated emmer does, however, suggest the gene to be a diversification gene in this species. Further studies of genotype-environment interactions are needed to find out under what conditions selection on different NAM-B1 alleles have been beneficial.

  • Schwarz, Iris-Corinna
    et al.
    Stockholm University, Faculty of Humanities, Department of Linguistics, Phonetics.
    Botros, Noor
    Karolinska Institutet.
    Lord, Alekzandra
    Karolinska Institutet.
    Marcusson, Amelie
    Karolinska Institutet.
    Tidelius, Henrik
    Karolinska Institutet.
    Marklund, Ellen
    Stockholm University, Faculty of Humanities, Department of Linguistics, Phonetics.
    The LENATM system applied to Swedish: Reliability of the Adult Word Count estimate2017In: Proceedings of the 18th Annual Conference of the International Speech Communication Association (INTERSPEECH 2017) / [ed] Marcin Wlodarczak, STockholm: The International Speech Communication Association (ISCA), 2017, 2088-2092 p., 1287Conference paper (Refereed)
    Abstract [en]

    The Language Environment Analysis system LENATM is used to capture day-long recordings of children’s natural audio environment. The system performs automated segmentation of the recordings and provides estimates for various measures. One of those measures is Adult Word Count (AWC), an approximation of the number of words spoken by adults in close proximity to the child. The LENA system was developed for and trained on American English, but it has also been evaluated on its performance when applied to Spanish, Mandarin and French. The present study is the first evaluation of the LENA system applied to Swedish, and focuses on the AWC estimate. Twelve five-minute segments were selected at random from each of four day-long recordings of 30-month-old children. Each of these 48 segments was transcribed by two transcribers,and both number of words and number of vowels were calculated (inter-transcriber reliability for words: r = .95,vowels: r = .93). Both counts correlated with the LENA system’s AWC estimate for the same segments (words: r = .67, vowels: r = .66). The reliability of the AWC as estimated by the LENA system when applied to Swedish is therefore comparableto its reliability for Spanish, Mandarin and French.

  • Wallensteen, Peter
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Peace and Conflict Research.
    Nordquist, Kjell-Åke
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Peace and Conflict Research.
    Hagelin, Björn
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Peace and Conflict Research.
    Melander, Erik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Peace and Conflict Research.
    Towards a security community in the Baltic region: Patterns of Peace and Conflict1994Book (Other academic)
  • Magnusson, Andreas
    Jönköping University, School of Education and Communication.
    Från ett perspektiv på ekologiska processer till ett verktyg för att diskutera hållbarhetsfrågor: Hur ekosystemtjänster – ett nytt ämnesinnehåll, kan ta form i undervisningspraktiken2017Licentiate thesis, monograph (Other academic)
    Abstract [en]

    The aim of this study was to generate knowledge about how teachers embark on new subject content and how their understandings of ecosystem services evolve and change in teaching practice, and also what it means to be able to discuss the relationship between the ecological and social in terms of ecosystem services in a teaching practice in middle school.

    The teachers used the learning study model and variation theory to explore the object of learning, by trying to design an instruction that offers fifth grade students the possibility to develop their knowledge of ecosystem services. The learning study model is an interventionist approach, where the focus is on an object of learning. A group of teachers worked together and tested students, planned lessons and implemented, evaluated and refined the lessons in an iterative process.

    The theoretical framework, variation theory, is a theory of learning that focuses on how discernment of aspects affects the way we perceive our world and how variation can be used to promote learning. However, since the study aims at contributing to enhancing our knowledge of how teachers can develop their skills and their meanings of a new content in practice, the empirical data from learning study was then analyzed with the help of activity theory, and the cycle of expansive learning.

    The result of the study shows that it can be complicated to introduce a new educational content. However, the learning study model proved to be aneffective tool for developing teachers' knowledge of ecosystem services and how to teach this. Ecosystem services were developed as teachers worked systematically with the content in their practice. For example, when the students did not respond to the exercises and to the reasoning of the ecosystem services that the teachers had planned, contradictions were created and changed the learning object's meaning for the teachers. The recordings from the lessons made the contradictions that arose during the lesson visible. Ecosystem services were developed from being primarily a tool to describe the human needs of the non-human nature to a tool to be able to discuss sustainability issues and the relationship between ecological, economic and social dimensions.

  • Otterbring, Tobias
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Service Research Center.
    Smile for a while: The effect of employee-displayed smiling on customer affect and satisfaction2017In: Journal of Service Management, ISSN 1757-5818, E-ISSN 1757-5826, Vol. 28, no 2, 284-304 p.Article in journal (Refereed)
    Abstract [en]

    Purpose - The purpose of this paper is to investigate the effect of employee-displayed smiling on customers' affective states (pleasure, arousal, and dominance) and satisfaction. Building on the stimulus-organism-response framework and theories of emotional contagion and feelings-as-information, the main hypothesis was that a smiling (vs non-smiling) employee significantly increases customer satisfaction through the mediating influence of pleasure. Design/methodology/approach - The study used a quasi-experimental two-group between-subjects design. A total of 210 customers at a large retail bank had a brief service encounter at the store entrance with a smiling (vs non-smiling) bank teller. Customers then went into the bank to do what they came to do. Before leaving the bank, customers completed a survey that included demographic information, affect (pleasure, arousal, and dominance), and measures of customer satisfaction. Findings - A smiling (vs non-smiling) employee had a significant positive impact on customer satisfaction. This effect was mediated by pleasure, but also, to a weaker extent, by dominance. These results contradict previous claims that smiling-induced emotional contagion does not remain throughout the completion of a service encounter. Practical implications - Managers should encourage, and potentially train, employees to act in ways associated with positive emotions. Managers could also hire employees based on how good they are at acting and expressing themselves in a genuinely positive manner and create a pleasant store atmosphere so that the feelings and behaviors displayed by frontline employees are genuine rather than inauthentic. Originality/value - This is the first experimental field study to examine the isolated effect that employee-displayed smiling has on customers' affective states and satisfaction. The results provide more direct evidence for the psychological processes justified by emotional contagion and feelings-as-information theories. Furthermore, the finding that dominance mediates the smiling-satisfaction link has never been shown before.

  • Lennerholt, Christian
    et al.
    University of Skövde, School of Informatics. University of Skövde, The Informatics Research Centre.
    van Laere, Joeri
    University of Skövde, School of Informatics. University of Skövde, The Informatics Research Centre.
    Söderström, Eva
    University of Skövde, School of Informatics. University of Skövde, The Informatics Research Centre.
    Implementation challenges of Self Service Business Intelligence: A literature review2018In: Proceedings of the 51st Hawaii International Conference on System Sciences, Hilton Waikoloa Village, Hawaii, USA: ScholarSpace , 2018, Vol. 51, 5055-5063 p., 0633Conference paper (Refereed)
    Abstract [en]

    In a traditional Business Intelligence (BI) system, power users serve less experienced casual users. Power users analyze and gather data requested by casual users, and produce the reports and visualizations that casual users base their decisions on. When data volumes and the usage frequency of a traditional BI system increase, power users have problems serving all the requests from casual users. The Self Service Business Intelligence (SSBI) approach can enable users to be more self-reliant and less dependent on power users. Although SSBI promises more benefits compared to a traditional BI system, many organizations fail to implement SSBI. The literature review presented in this paper discusses six SSBI challenges related to "Access and use of data" and four challenges related to "Self-reliant users". Awareness of these ten challenges can help practitioners avoid common pitfalls, when implementing SSBI, as well as guide SSBI researchers in focusing on their future research efforts.

  • Sordo-Ward, Alvaro
    et al.
    Dolores Bejarano, Maria
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Iglesias, Ana
    Asenjo, Victor
    Garrote, Luis
    Analysis of Current and Future SPEI Droughts in the La Plata Basin Based on Results from the Regional Eta Climate Model2017In: Water, ISSN 2073-4441, E-ISSN 2073-4441, Vol. 9, no 11, 857Article in journal (Refereed)
    Abstract [en]

    We identified and analysed droughts in the La Plata Basin (divided into seven sub-basins) for the current period (1961-2005) and estimated their expected evolution under future climate projections for the periods 2011-2040, 2041-2070, and 2071-2099. Future climate projections were analysed from results of the Eta Regional Climate Model (grid resolution of approximately 10 km) forced by the global climate model HadGEM2-ES over the La Plata basin, and considering a RCP4.5 emission scenario. Within each sub-basin, we particularly focused our drought analyses on croplands and grasslands, due to their economic relevance. The three-month Standardized Precipitation Evapotranspiration Index (SPEI3) was used for drought identification and characterization. Droughts were evaluated in terms of time (percentage of time from the total length of each climate scenario), space (percentage of total area), and severity (SPEI3 values) of cells characterized by cropland and grassland for each sub-basin and climate scenario. Drought-severity-area-frequency curves were developed to quantitatively relate the frequency distribution of drought occurrence to drought severity and area. For the period 2011-2040, droughts dominate the northern sub-basins, whereas alternating wet and short dry periods dominate the southern sub-basins. Wet climate spread from south to north within the La Plata Basin as more distant future scenarios were analysed, due to both a greater number of wet periods and fewer droughts. The area of each sub-basin affected by drought in all climate scenarios was highly varied temporally and spatially. The likelihood of the occurrence of droughts differed significantly between the studied cover types in the Lower Paraguay sub-basin, being higher for cropland than for grassland. Mainly in the Upper Paraguay and in the Upper Parana basins the climate projections for all scenarios showed an increase of moderate and severe droughts over large regions dedicated to crops and grasses. On the other hand, for the near future, the Lower Uruguay and the River Plata basins showed a decrease of drought severity compared to the current period. Projections suggest an increase in competition among uses in these regions and the need for a potential relocation of certain crops from the northern regions towards cooler regions located in the centre and south. Further research should consider other climate projections and perform high spatial resolution studies in localized areas.

  • Chen, Jialin
    et al.
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy. Center for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, Zhejiang; Zhejiang Provincial Key Lab forTissue Engineering and Regenerative Medicine, Hangzhou, Zhejiang, People’s Republic of China.
    Zhang, Erchen
    Zhang, Wei
    Liu, Zeyu
    Lu, Ping
    Zhu, Ting
    Yin, Zi
    Backman, Ludvig J.
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
    Liu, Huanhuan
    Chen, Xiao
    Ouyang, Hongwei
    Fos Promotes Early Stage Teno-Lineage Differentiation of Tendon Stem/Progenitor Cells in Tendon2017In: Stem Cells Translational Medicine, ISSN 2157-6564, E-ISSN 2157-6580, Vol. 6, no 11, 2009-2019 p.Article in journal (Refereed)
    Abstract [en]

    Stem cells have been widely used in tendon tissue engineering. The lack of refined and controlled differentiation strategy hampers the tendon repair and regeneration. This study aimed to find new effective differentiation factors for stepwise tenogenic differentiation. By microarray screening, the transcript factor Fos was found to be expressed in significantly higher amounts in postnatal Achilles tendon tissue derived from 1 day as compared with 7-days-old rats. It was further confirmed that expression of Fos decreased with time in postnatal rat Achilles tendon, which was accompanied with the decreased expression of multiply tendon markers. The expression of Fos also declined during regular in vitro cell culture, which corresponded to the loss of tendon phenotype. In a cell-sheet and a three-dimensional cell culture model, the expression of Fos was upregulated as compared with in regular cell culture, together with the recovery of tendon phenotype. In addition, significant higher expression of tendon markers was found in Fos-overexpressed tendon stem/progenitor cells (TSPCs), and Fos knock-down gave opposite results. In situ rat tendon repair experiments found more normal tendon-like tissue formed and higher tendon markers expression at 4 weeks postimplantation of Fos-overexpressed TSPCs derived nonscaffold engineering tendon (cell-sheet), as compared with the control group. This study identifies Fos as a new marker and functional driver in the early stage teno-lineage differentiation of tendon, which paves the way for effective stepwise tendon differentiation and future tendon regeneration.

  • Prioreschi, Alessandra
    et al.
    Wrottesley, Stephanie V.
    Cohen, Emmanuel
    Reddy, Ankita
    Said-Mohamed, Rihlat
    Twine, Rhian
    Tollman, Stephen M.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa ; INDEPTH Network, Accra, Ghana.
    Kahn, Kathleen
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa ; INDEPTH Network, Accra, Ghana.
    Dunger, David B.
    Norris, Shane A.
    Examining the relationships between body image, eating attitudes, BMI, and physical activity in rural and urban South African young adult females using structural equation modeling2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 11, e0187508Article in journal (Refereed)
    Abstract [en]

    The persistence of food insecurity, malnutrition, increasing adiposity, and decreasing physical activity, heightens the need to understand relationships between body image satisfaction, eating attitudes, BMI and physical activity levels in South Africa. Females aged 18-23 years were recruited from rural (n = 509) and urban (n = 510) settings. Body image satisfaction was measured using Stunkard's silhouettes, and the 26-item Eating Attitudes questionnaire (EAT-26) was used to evaluate participants' risk of disordered eating. Minutes per week of moderate to vigorous physical activity (MVPA) was assessed using the Global Physical Activity Questionnaire (GPAQ). Significant linear correlates were included in a series of regressions run separately for urban and rural participants. Structural equation modeling (SEM) was used to test the relationships between variables. Urban females were more likely to be overweight and obese than rural females (p = 0.02), and had a greater desire to be thinner (p = 0.02). In both groups, being overweight or obese was positively associated with a desire to be thinner (p<0.01), and negatively associated with a desire to be fatter (p<0.01). Having a disordered eating attitude was associated with body image dissatisfaction in the urban group (beta = 1.27, p<0.01, CI: 0.38; 2.16), but only with a desire to be fatter in the rural group (beta = 0.63, p = 0.04, CI: 0.03; 1.23). In the SEM model, body image dissatisfaction was associated with disordered eating (beta = 0.63), as well as higher MVPA participation (p<0.01). These factors were directly associated with a decreased risk of disordered eating attitude, and with a decreased desire to be thinner. Findings indicate a shift in both settings towards more Westernised ideals. Physical activity may provide a means to promote a healthy body image, while reducing the risk of disordered eating. Given the high prevalence of overweight and obesity in both rural and urban women, this study provides insights for future interventions aimed at decreasing adiposity in a healthy way.

  • Reeploeg, Silke
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Department of Political, Historical, Religious and Cultural Studies.
    The Far Islands and Other Cold Places: Women Travellers in the Arctic, 1850-19352017In: Conference of the International Journal of Arts and Sciences, ISSN 1943-6114, Vol. 10, no 2, 35-40 p.Article in journal (Refereed)
    Abstract [en]

    Current Research (2016-18)

    Project title:  Women in the Arctic, 1818-2018

    The project Women in the Arctic examines the intercultural aspects of how women are represented in circumpolar societies.  It will place representations of women in migratory literature within the existing 'Northern' cultural landscapes and histories, but also seek a new methodology that analyses their position within the context of global diversity.  Migration often leads to the emergence of ‘geographically diffuse socio-cultural fields’ (Olwig, 2003), which cross political and geographical borders.  Although these always impose some sort of structural constraint, this does not necessarily change the nature or continuity of the relationship, feelings of affinity or images of difference and/or transgression.  The project focuses on: 

    1. understanding the diverse roles that women have played in the history of the Arctic, both as colonisers and colonised, and
    2. demonstrating the contemporary issues affecting women in the Arctic. 
  • Runesson Kempe, Ulla
    et al.
    Jönköping University, School of Education and Communication, HLK, Praktiknära utbildningsforskning (PUF), Mathematics Education Research. Wits School of Education, University of the Witwatersrand, Johannesburg, South Africa.
    Lövström, Anna
    Mörbylånga municipality, Mörbylånga, Sweden.
    Theory-informed lesson study as practice based research: identifying what is critical for grade 2 and 3 pupils’ learning of negative numbers2017In: Quadrante, ISSN 0872-3915, Vol. XXVI, no 2, 19-42 p.Article in journal (Refereed)
    Abstract [en]

    The aim of the paper is to demonstrate how a theory-informed lesson study can be a form of practice-based research where knowledge is generated within the process of teachers’ actions. Learning study shares features with lesson study, such as the iterative design, the teacher driven approach and with attention to student learning, but is guided by a theoretical framework. The dominant theory has been variation theory. In learning study, the focus is the object of learning and what must be learned to make the object of learning one’s own. A learning study about learning and teaching negative numbers to young pupils (age 8-9) in a Swedish context is used as an example. Our proposal is in resonance with Morris’ and Hiebert’s (2011) suggestion; that lesson study is a system that can generate instructional products that are sharable and open for improvement by other actors. The ‘instructional product’ from learning study is a theoretical description of the object of learning, how it is constituted and can be taught. In the learning study reported, three teachers worked in collaboration to identify the critical aspects for realizing the existence of negative numbers. The critical aspects emerged and were successively specified in the process and as a result of a thorough analysis of data on pupils’ learning and the lessons. 

  • Dahlqvist, Helene Zetterstrom
    et al.
    Landstedt, Evelina
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Almqvist, Ylva B.
    Gadin, Katja Gillander
    A non-randomised pragmatic trial of a school-based group cognitive-behavioural programme for preventing depression in girls2017In: International Journal of Circumpolar Health, ISSN 1239-9736, E-ISSN 2242-3982, Vol. 76, 1396146Article in journal (Refereed)
    Abstract [en]

    The aim of this study was to investigate the effectiveness of the DISA-programme in preventing depressive symptoms (DS) in adolescent girls, as implemented in a real-world school setting, accounting for baseline socioeconomic and psychosocial factors, and to investigate whether the effects of these baseline variables on DS differed between intervention participants and non-participants. In this non-randomised pragmatic trial, an electronic questionnaire was disseminated in 2011 (baseline) and 2012 (follow-up) in schools in one municipality in northern Sweden. Pupils (total n=275; intervention participants identified in the questionnaire: n=53; non-participants: n=222) were 14-15 years old at baseline. The groups were compared by means of SEM. DISA could not predict differences in DS at follow-up in this real-life setting. In the overall sample, sexual harassment victimisation (SH) at baseline was associated with DS at follow-up and the estimate for SH increased in the DISA-participants compared to the overall sample.

  • Johansson, Björn J. E.
    et al.
    Linköping University, Sweden.
    van Laere, Joeri
    University of Skövde, School of Informatics. University of Skövde, The Informatics Research Centre.
    Berggren, Peter
    Linköping University, Sweden.
    Using simulation games to assess critical infrastructure resilience in case of payment disruptions2017In: Proceedings of the 7th Resilience Engingeering Association (REA) International Symposium, Liege, Belgium, 26-29 June 2017, 2017, 1-7 p.Conference paper (Refereed)
    Abstract [en]

    This paper presents a theoretical outline, and a tentative assessment approach, for resilience in the fuel, food, and finance systems needed to create a gaming simulation environment. The purpose of developing the simulation gaming environment is to provide team-training to decision-makers in handling crisis situations in a multi-organisational context. Gaming simulation aims at representing reality and enabling an individual actor or a group of actors to experience the dynamics of the simulated system. The concept of core values and resilience value networks will be used to guide the simulation approach so that all core functions of a resilient system, as well as coping strategies, will be addressed in the gaming sessions.

  • Kaltsas, Gregory
    et al.
    Univ Athens, Dept Pathophysiol, Endocrine Unit.
    Caplin, Martyn
    Royal Free Hosp, Neuroendocrine Tumour Unit.
    Davies, Philippa
    Royal Free Hosp, Neuroendocrine Tumour Unit.
    Ferone, Diego
    Univ Genoa, IRCCS AOU San Martino IST, Dept Internal Med & Med Specialties DiMI, Endocrinol Unit, CEBR.
    Garcia-Carbonero, Rocio
    Hosp Univ Doce Octubre, Med Oncol Dept.
    Grozinsky-Glasberg, Simona
    Hadassah Hebrew Univ, Med Ctr, Endocrinol & Metab Serv, Neuroendocrine Unit.
    Hoersch, Dieter
    Gastroenterol & Endocrinol Ctr Neuroendocrine Tum.
    Tiensuu Janson, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology.
    Kianmanesh, Reza
    Robert Debre Hosp, Dept Digest & Endocrine Surg.
    Kos-Kudla, Beata
    Med Univ Silesia, Div Endocrinol, Dept Pathophysiol & Endocrinol.
    Pavel, Marianne
    Charite Univ Med Berlin, Campus Virchow Klinikum, Dept Hepatol & Gastroenterol.
    Rinke, Anja
    UKGM Marburg, Dept Gastroenterol.;Philipps Univ Marburg.
    Falconi, Massimo
    Univ Vita & Salute, Osped San Raffaele, Pancreas Translat & Clin Res Ctr, Chirurg Pancreas.
    de Herder, Wouter W.
    Erasmus MC Canc Ctr, ENETS Ctr Excellence.
    ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Pre- and Perioperative Therapy in Patients with Neuroendocrine Tumors2017In: Neuroendocrinology, ISSN 0028-3835, E-ISSN 1423-0194, Vol. 105, no 3, 245-254 p.Article in journal (Refereed)
    Abstract [en]

    Neuroendocrine tumors of the small intestine are the most common causes of the carcinoid syndrome. Carcinoid heart disease occurs in more than half of the patients with the carcinoid syndrome. Patients with carcinoid heart disease who need to undergo surgery should also undergo preoperative evaluation by an expert cardiologist. Treatment with longacting somatostatin analogs aims at controlling the excessive hormonal output and symptoms related to the carcinoid syndrome and at preventing a carcinoid crisis during interventions. Patients with a gastrinoma require pre- and postoperative treatment with high doses of proton pump inhibitors. Patients with a glucagonoma require somatostatin analog treatment and nutritional supplementation. Patients with a VIPoma also require somatostatin analog treatment and intravenous fluid and electrolyte therapy. Insulinoma patients generally require intravenous glucose infusion prior to operation. In patients with localized operable insulinoma, somatostatin analog infusion should only be considered after the effect of this therapy has been electively studied.

  • Gattringer, Johannes P.
    et al.
    Justus Liebig Univ Giessen, Res Ctr Biosyst Land Use & Nutr IFZ, Div Landscape Ecol & Landscape Planning, Giessen, Germany..
    Donath, Tobias W.
    Univ Kiel, Inst Nat Resource Conservat, Dept Landscape Ecol, Kiel, Germany..
    Eckstein, R. Lutz
    Karlstad Univ, Dept Environm & Life Sci Biol, Karlstad, Sweden..
    Ludewig, Kristin
    Justus Liebig Univ Giessen, Res Ctr Biosyst Land Use & Nutr IFZ, Div Landscape Ecol & Landscape Planning, Giessen, Germany..
    Otte, Annette
    Justus Liebig Univ Giessen, Res Ctr Biosyst Land Use & Nutr IFZ, Div Landscape Ecol & Landscape Planning, Giessen, Germany..
    Harvolk-Schoening, Sarah
    Justus Liebig Univ Giessen, Res Ctr Biosyst Land Use & Nutr IFZ, Div Landscape Ecol & Landscape Planning, Giessen, Germany..
    Flooding tolerance of four floodplain meadow species depends on age2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 5, e0176869Article in journal (Refereed)
    Abstract [en]

    Numerous restoration campaigns focused on re-establishing species-rich floodplain meadows of Central Europe, whose species composition is essentially controlled by regular flooding. Climate change predictions expect strong alterations on the discharge regime of Europe's large rivers with little-known consequences on floodplain meadow plants. In this study, we aim to determine the effects of flooding on seedlings of different ages of four typical flood meadow species. To this end, we flooded seedlings of two familial pairs of flood meadow species of wetter and dryer microhabitats for 2 weeks each, starting 2, 4, 6, and 8 weeks after seedling germination, respectively. We show that a 2-week-flooding treatment had a negative effect on performance of seedlings younger than 6 weeks. Summer floods with high floodwater temperatures may have especially detrimental effects on seedlings, which is corroborated by previous findings. As expected, the plants from wet floodplain meadow microhabitats coped better with the flooding treatment than those from dryer microhabitats. In conclusion, our results suggest that restoration measures may perform more successfully if seedlings of restored species are older than the critical age of about 6 weeks before a spring flooding begins. Seasonal flow patterns may influence vegetation dynamics of floodplain meadows and should, therefore, be taken into account when timing future restoration campaigns.

  • Espinosa-Garcia, W. F.
    et al.
    Universidad de San Buenaventura-Medellín, Facultad de Ingenierías, Grupo de Investigación en Modelamiento y Simulación Computacional; Universidad de Antioquia UdeA, Instituto de Física.
    Osorio-Guillen, J. M.
    Universidad de Antioquia UdeA, Instituto de Física.
    Araujo, Carlos Moyses
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Dimension-dependent band alignment and excitonic effects in graphitic carbon nitride: a many-body perturbation and time-dependent density functional theory study2017In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 7, no 71, 44997-45002 p.Article in journal (Refereed)
    Abstract [en]

    First-principles many-body theory and time-dependent density functional theory were used to study the dimension effects on the band alignment and optical properties of s-triazine and graphitic C3N4. The inclusion of quasiparticle corrections is very important to describe the quantum confinement and the enhancement of the electron-electron (e-e) interaction. The calculated quasiparticle gaps range from 4.0 eV (monolayer) to 3.21 eV (tetralayer). The position of the valence band maxima is found to be almost constant, whereas the conduction band minima show a strong quantum confinement effect with a variation of similar to 0.7 eV respective to the bulk structure. The calculated frequency-dependent imaginary part of the dielectric function using the Bethe-Salpeter equation shows prominent excitonic effects, where there is a strong redistribution of the spectral weight to lower photon energies in the ultraviolet frequencies where the major part of the absorption occurs. On the other hand, a less intense excitonic absorption in the visible region is due to light polarization perpendicular to the surface plane. In contrast, time-dependent density functional theory also shows a redistribution of the spectral weight in the ultraviolet but it fails to describe the excitonic features in the visible region.

  • Tissera, Hasitha
    et al.
    Rathore, Abhay P. S.
    Leong, Wei Yee
    Pike, Brian L.
    Warkentien, Tyler E.
    Farouk, Farouk S.
    Syenina, Ayesa
    Ooi, Eng Eong
    Gubler, Duane J.
    Wilder-Smith, Annelies
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
    John, Ashley L. St.
    Chymase Level Is a Predictive Biomarker of Dengue Hemorrhagic Fever in Pediatric and Adult Patients2017In: Journal of Infectious Diseases, ISSN 0022-1899, E-ISSN 1537-6613, Vol. 216, no 9, 1112-1121 p.Article in journal (Refereed)
    Abstract [en]

    Background. Most patients with dengue experience mild disease, dengue fever (DF), while few develop the life-threatening diseases dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). No laboratory tests predict DHF or DSS. We evaluated whether the serum chymase level can predict DHF or DSS in adult and pediatric patients and the influence of preexisting conditions (PECs) on chymase levels. Methods. Serum chymase levels were measured in patients presenting with undifferentiated fever to hospitals in Colombo District, Sri Lanka. The value of serum the chymase concentration and clinical signs and symptoms as predictors of DHF and/or DSS was evaluated by multivariate analysis. We assessed the influence of age, PECs, and day after fever onset on the robustness of the chymase level as a biomarker for DHF and/or DSS. Results. An elevated chymase level in acute phase blood samples was highly indicative of later diagnosis of DHF or DSS for pediatric and adult patients with dengue. No recorded PECs prevented an increase in the chymase level during DHF. However, certain PECs (obesity and cardiac or lung-associated diseases) resulted in a concomitant increase in chymase levels among adult patients with DHF. Conclusions. These results show that patients with acute dengue who present with high levels of serum chymase consistently are at greater risk of DHF. The chymase level is a robust prognostic biomarker of severe dengue for adult and pediatric patients.

  • Alho, Artur
    et al.
    Univ Lisbon, Inst Super Tecn, Ctr Math Anal Geometry & Dynam Syst, Av Rovisco Pais, P-1049001 Lisbon, Portugal..
    Uggla, Claes
    Karlstad Univ, Dept Phys, Av Univ Gatan 1-2, S-65188 Karlstad, Sweden..
    Inflationary alpha-attractor cosmology: A global dynamical systems perspective2017In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 95, no 8, 083517Article in journal (Refereed)
    Abstract [en]

    We study flat Friedmann-Lemaitre-Robertson-Walker alpha-attractor E- and T-models by introducing a dynamical systems framework that yields regularized unconstrained field equations on two-dimensional compact state spaces. This results in both illustrative figures and a complete description of the entire solution spaces of these models, including asymptotics. In particular, it is shown that observational viability, which requires a sufficient number of e-folds, is associated with a particular solution given by a one-dimensional center manifold of a past asymptotic de Sitter state, where the center manifold structure also explains why nearby solutions are attracted to this "inflationary attractor solution." A center manifold expansion yields a description of the inflationary regime with arbitrary analytic accuracy, where the slow-roll approximation asymptotically describes the tangency condition of the center manifold at the asymptotic de Sitter state.

  • Boss, Anna
    et al.
    RISE - Research Institutes of Sweden, Built Environment, Energy and Circular Economy.
    Sacco, Francesco
    RISE - Research Institutes of Sweden, Built Environment, Building Technology.
    Molnar, Stefan
    RISE - Research Institutes of Sweden, Built Environment, Energy and Circular Economy.
    Folland, Anna
    Hedén, Alice
    Renobuild 2.0 – verktyg för systematisk hållbarhetsutvärdering vid renovering2017Report (Other academic)
    Abstract [sv]

    Fastighetsbeståndet i Sverige och resten av Europa är i behov av omfattande renoveringar för att uppnå minskade koldioxidutsläpp, skapa förbättrade livsvillkor för människor och öka dess ekonomiska bärkraft. Men det är inte alltid lätt att veta hur dessa mål ska uppnås och balanseras. Därför har RISE tillsammans med partners i fastighetsbranschen tagit fram Renobuild – en beslutsmetod för att utvärdera renoveringar utifrån ett hållbarhetsperspektiv. I projektet har två versioner av metodiken tagits fram, testats och vidareutvecklats via fallstudier. I Renobuild Bostad utvärderas renoveringar av flerbostadshus och deras omgivningar. Analysen tar hänsyn till klimatpåverkan, livscykelkostnader och sociala faktorer så som trygghet, säkerhet, hälsa och sociala relationer. Renobuild Skola utvärderar skolrenoveringar och dess effekter på ekonomi, miljö och sociala aspekter så som elevers lärande, trygghet och sociala relationer. Resultatet ger en sammantagen hållbarhetsvärdering som fördjupar fastighetsägares och samarbetspartners förståelse för möjliga konsekvenser av olika renoveringsalternativ. Renobuild består av ett Excelark och en användarhandbok som är fritt tillgängliga för vem som helst att använda. Dessa nås via en webbsida tillsammans med bakgrundsmaterial. En del av det materialet är den här rapporten som ämnar ge en djupare förståelse för hur metodiken har utvecklats. Rapporten beskriver vad användaren kan utvärdera med hjälp av dessa verktyg, hur verktyget behandlar indata, hur resultatet framställs och visualiseras samt hur den nya version 2.0 skiljer sig från en tidigare version. Här beskrivs också hur bakgrundsdata och teori har används för att utveckla innehållet i verktygen. Dessutom diskuteras det vilka avgränsningar som har gjorts i den miljömässiga, ekonomiska och sociala analysen – alltså reflektioner kring systemgränserna för respektive hållbarhetsdimension. Förhoppningen är att metodiken ska spridas i fastighetsbranschen och därmed generera en större medvetenhet om hållbarhetsfrågor vid renoveringar.

  • Pettersson, Linda F.
    et al.
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy. Umeå University, Faculty of Medicine, Department of Odontology.
    Kingham, Paul J.
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
    Wiberg, Mikael
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy. Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
    Kelk, Peyman
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
    In Vitro Osteogenic Differentiation of Human Mesenchymal Stem Cells from Jawbone Compared with Dental Tissue2017In: Tissue Engineering and Regenerative Medicine, ISSN 1738-2696, Vol. 14, no 6, 763-774 p.Article in journal (Refereed)
    Abstract [en]

    Autologous bone transplantation is the current gold standard for reconstruction of jawbone defects. Bone regeneration using mesenchymal stem cells (MSC) is an interesting alternative to improve the current techniques, which necessitate a second site of surgery resulting in donor site morbidity. In this study, we compared the osteogenic ability of jawbone MSC (JB-MSC) with MSC from tissues with neural crest origin, namely, the dental pulp, apical papilla and periodontal ligament. All four types of MSC were isolated from the same patient (n = 3 donors) to exclude inter-individual variations. The MSC growth and differentiation properties were characterized. The osteogenic differentiation potential in each group of cells was assessed quantitatively to determine if there were any differences between the cell types. All cells expressed the MSC-associated surface markers CD73, CD90, CD105, and CD146 and were negative for CD11b, CD19, CD34, CD45 and HLA-DR. All cell types proliferated at similar rates, exhibited similar clonogenic activity and could differentiate into adipocytes and osteoblasts. An alkaline phosphatase assay, OsteoImageTM assay for mineralization and qRT-PCR measuring the genes runx2, ALP and OCN, indicated that there were no significant differences in the osteogenic differentiation ability between the various MSCs. In conclusion, we show that from a small segment of jawbone it is possible to isolate sufficient quantities of MSC and that these cells can easily be expanded and differentiated into osteoblasts. JB-MSC appear to be good candidates for future bone regeneration applications in the craniofacial region.

  • Ma, Zuheng
    et al.
    Karolinska Institutet, Karolinska University Hospital, Department of Molecular Medicine and Surgery.
    Bjorklund, Anneli
    Karolinska Institutet, Karolinska University Hospital, Department of Molecular Medicine and Surgery.
    Islam, Md. Shahidul
    Karolinska Institutet, Research Center, Södersjukhuset, Department of Clinical Science and Education; Uppsala University Hospital, Department of Emergency Care and Internal Medicine.
    A TRPM4 Inhibitor 9-Phenanthrol Inhibits Glucose- and Glucagon-Like Peptide 1-Induced Insulin Secretion from Rat Islets of Langerhans2017In: Journal of Diabetes Research, ISSN 2314-6745, E-ISSN 2314-6753, 5131785Article in journal (Refereed)
    Abstract [en]

    Pancreatic beta-cells express several ion channels of the transient receptor potential family, which play important roles in mediating the stimulus-secretion coupling. One of these channels, the TRPM4 is a Ca2+-activated monovalent cation channel. This channel is inhibited by 9-phenanthrol, which also inhibits the TMEM16a Cl- channel, and activates the Ca2+-activated K+ channel, K(ca)3.1. The net effects of ion-channel modulation by 9-phenantherol on the insulin secretion remain unclear. We tested the effects of 9-phenanthrol on glucose-and GLP-1-induced insulin secretion from isolated rat islets in static incubations. When applied to the islets in the presence of 3.3mM glucose, 9-phenanthrol caused a small increase in insulin secretion (similar to 7% of the insulin secretion stimulated by 10mM glucose). 10 mu M 9-phenanthrol did not inhibit glucose-or GLP-1-induced insulin secretion. 20 mu M and 30 mu M 9-phenanthrol inhibited glucose-induced insulin secretion by similar to 80% and similar to 85%, respectively. Inhibition of the GLP-1-induced insulin secretion by 20 mu M and 30 mu M 9-phenanthrol was 65% and 94%, respectively. Our study shows that the major effect of 9-phenanthrol on the islets is a strong inhibition of insulin secretion, and we speculate that compounds related to 9-phenanthrol may be potentially useful in treating the pancreatogenous hyperinsulinemic hypoglycemia syndromes.

  • Makdoumi, Karim
    et al.
    Nilsson, Torbjörn K.
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry. Faculty of Medicine and Health, Department of Biomedicine, Örebro University, Örebro, Sweden.
    Crafoord, Sven
    Levels of beta-trace protein in optic disc pit with macular detachment2017In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 95, no 8, 815-819 p.Article in journal (Refereed)
    Abstract [en]

    Background: To report beta-trace protein (bTP) levels in the subretinal fluid (SRF) of four patients with a macular detachment associated with optic disc pit (ODP).

    Methods: Four patients with a serous retinal detachment involving the macula was operated by pars plana vitrectomy (PPV) with C2F6 gas tamponade and peeling of internal limiting membrane (ILM). Patients with a follow-up period exceeding one year postoperatively were included in the study. The SRF was drained using a fine cannula without laser photocoagulation, and the samples were analysed using particle-enhancing nephelometry. The levels of bTP were compared to 20 routine cerebrospinal fluid (CSF) samples.

    Results: In four of the five samples from SRF had relatively low bTP levels, with a mean concentration of 6.6 mg/l (range 2.0 to 23.1 mg/l) compared to 16.0 mg/ l (range 6.3-26.8 mg/l) in CSF. The only SRF sample within the range corresponding to normal CSF was the first sample from patient 4, and the analysis of the renewed aspirate during the second operation was 2.8 mg/l. Postoperatively, the regression of SRF was slow, but regression of SRF in the foveal region took place in all cases; however, visual acuity (VA) was improved in only half of the patients.

    Conclusion: The results from the analysed SRF regarding bTP concentration in these patients indicate that the SRF in ODP is not identical to CSF, as the concentrations of bTP differ.

  • Public defence: 2018-01-26 13:15 Planck, Hus F, Linköping
    Ivanova, Valentina
    Linköping University, Department of Computer and Information Science, Database and information techniques. Linköping University, Faculty of Science & Engineering.
    Fostering User Involvement in Ontology Alignment and Alignment Evaluation2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The abundance of data at our disposal empowers data-driven applications and decision making. The knowledge captured in the data, however, has not been utilized to full potential, as it is only accessible to human interpretation and data are distributed in heterogeneous repositories.

    Ontologies are a key technology unlocking the knowledge in the data by providing means to model the world around us and infer knowledge implicitly captured in the data. As data are hosted by independent organizations we often need to use several ontologies and discover the relationships between them in order to support data and knowledge transfer. Broadly speaking, while ontologies provide formal representations and thus the basis, ontology alignment supplies integration techniques and thus the means to turn the data kept in distributed, heterogeneous repositories into valuable knowledge.

    While many automatic approaches for creating alignments have already been developed, user input is still required for obtaining the highest-quality alignments. This thesis focuses on supporting users during the cognitively intensive alignment process and makes several contributions.

    We have identified front- and back-end system features that foster user involvement during the alignment process and have investigated their support in existing systems by user interface evaluations and literature studies. We have further narrowed down our investigation to features in connection to the, arguably, most cognitively demanding task from the users’ perspective—manual validation—and have also considered the level of user expertise by assessing the impact of user errors on alignments’ quality. As developing and aligning ontologies is an error-prone task, we have focused on the benefits of the integration of ontology alignment and debugging.

    We have enabled interactive comparative exploration and evaluation of multiple alignments at different levels of detail by developing a dedicated visual environment—Alignment Cubes—which allows for alignments’ evaluation even in the absence of reference alignments.

    Inspired by the latest technological advances we have investigated and identified three promising directions for the application of large, high-resolution displays in the field: improving the navigation in the ontologies and their alignments, supporting reasoning and collaboration between users.

  • Spetz, Jennie
    Institute for Language and Folklore, Språkrådet.
    Debatterad och marginaliserad: Perspektiv på modersmålsundervisningen2014Report (Other academic)
  • Lusey, Hendrew
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. Umeå University, Faculty of Medicine, Department of Nursing. World Council of Churches, Central Africa Regional Coordinator of the Ecumenical HIV and AIDS Initiative in Africa (EHAIA), Kinshasa Gombe, Democratic Republic of Congo.
    Sebastian, Miguel San
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Christianson, Monica
    Umeå University, Faculty of Medicine, Department of Nursing.
    Edin, Kerstin E.
    Umeå University, Faculty of Medicine, Department of Nursing.
    Factors associated with gender equality among church-going young men in Kinshasa, Democratic Republic of Congo: a cross-sectional study2017In: International Journal for Equity in Health, ISSN 1475-9276, E-ISSN 1475-9276, Vol. 16, 213Article in journal (Refereed)
    Abstract [en]

    Background: While women and girls are made vulnerable by inequitable and violent versions of masculinities, there is increasing evidence that gender equality will not be achieved without partnering with men. The aim of this study was to assess gender-equitable norms and their determinants among church-going young men in Kinshasa, the Democratic Republic of Congo.

    Method: A cross-sectional study was carried out among 289 church-going young men, aged 18-24 years, residing in three disadvantaged communes of Kinshasa. Variables included sociodemographic characteristics, attitudes towards gender equality and responses to issues related to the Gender-Equitable Men (GEM) scale. Logistic regression was applied to identify the associations between sociodemographic characteristics, attitudes and the GEM scale.

    Results: The findings provide evidence of attitudes and beliefs that act as barriers to gender equality. For instance, the majority of church-going young men (83.74%) agreed that a man is the only decision maker in the home and about half (50.87%) of the respondents supported the statement "There are times a woman deserves to be beaten". Similarly, around half of the participants agreed with the idea of men's uncontrollable sex drive (50.87%) and men's toughness (50.17%). Close to half of the participants (44.29%) agreed that it is women's responsibility to prevent pregnancy. These attitudes co-existed with a few gender-equitable norms as 82.70% agreed on the importance of joint decisions concerning family planning. An association between education, certain places of residence, being single or separated, and supportive attitudes towards gender equality was found with higher scores for the GEM.

    Conclusion: Our study findings indicate that a high proportion of church-going young men do not endorse gender-equitable norms. Therefore, churches urgently need comprehensive gender equality and masculinity policies and programmes to influence young men's attitudes and behaviours. The promotion of gender equality in schools and the wider community also need to be encouraged.

  • Barbosa, R. N.
    et al.
    Westerdijk Fungal Biodiversity Institute; Universidade Federal de Pernambuco, Departamento de Micologia Prof. Chaves Batista, Av. Prof. Moraes Rego.
    Leong, S. L.
    Swedish University of Agricultural Sciences, Department of Molecular Sciences.
    Vinnere, Olga
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab. Swedish University of Agricultural Sciences, Department of Molecular Sciences.
    Chen, A. J.
    Westerdijk Fungal Biodiversity Institute; Chinese Academy of Medical Sciences, Institute of Medicinal Plant Development; Peking Union Medical College.
    Souza-Motta, C. M.
    Universidade Federal de Pernambuco, Departamento de Micologia Prof. Chaves Batista, Av. Prof. Moraes Rego.
    Frisvad, J. C.
    Technical University of Denmark, Department of Biotechnology and Biomedicine.
    Samson, R. A.
    Westerdijk Fungal Biodiversity Institute.
    Oliveira, N. T.
    Universidade Federal de Pernambuco, Departamento de Micologia Prof. Chaves Batista, Av. Prof. Moraes Rego.
    Houbraken, J.
    Westerdijk Fungal Biodiversity Institute.
    Phylogenetic analysis of Monascus and new species from honey, pollen and nests of stingless bees2017In: Studies in mycology, ISSN 0166-0616, E-ISSN 1872-9797, no 86, 29-51 p.Article in journal (Refereed)
    Abstract [en]

    The genus Monascus was described by van Tieghem (1884) to accommodate M. ruber and M. mucoroides, two species with non-ostiolate ascomata. Species delimitation in the genus is still mainly based on phenotypic characters, and taxonomic studies that include sequence data are limited. The genus is of economic importance. Species are used in fermented Asian foods as food colourants (e.g. 'red rice' (ang-kak, angka)) and found as spoilage organisms, and recently Monascus was found to be essential in the lifecycle of stingless bees. In this study, a polyphasic approach was applied combining morphological characters, ITS, LSU, beta-tubulin, calmodulin and RNA polymerase II second largest subunit sequences and extrolite data, to delimit species and to study phylogenetic relationships in Monascus. Furthermore, 30 Monascus isolates from honey, pollen and nests of stingless bees in Brazil were included. Based on this polyphasic approach, the genus Monascus is resolved in nine species, including three new species associated with stingless bees (M. flavipigmentosus sp. nov., M. mellicola sp. nov., M. recifensis sp. nov., M. argentinensis, M. floridanus, M. lunisporas, M. pallens, M. purpureus, M. ruber), and split in two new sections (section Floridani sect. nov., section Rubri sect. nov.). Phylogenetic analysis showed that the xerophile Monascus eremophilus does not belong in Monascus and monophyly in Monascus is restored with the transfer of M. eremophilus to Penicillium (P. eremophilum comb. nov.). A list of accepted and excluded Monascus and Basipetospora species is given, together with information on (ex-)types cultures and barcode sequence data.

  • Schindele, Anna-ChuChu
    et al.
    Folkhälsomyndigheten.
    Wallin, Malin
    Folkhälsomyndigheten.
    Areskoug Josefsson, Kristina
    Jönköping University, School of Health and Welfare, The Jönköping Academy for Improvement of Health and Welfare.
    Lindroth, Malin
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Nursing Science. Jönköping University, School of Health and Welfare, HHJ. ADULT.
    Kartläggning av utbildning i hivprevention och SRHR: En kartläggande studie om hivprevention samt sexuell och reproduktiv hälsa och rättigheter (SRHR) inom människo- och rättsvårdande högre utbildning i Sverige2017Report (Other academic)
    Abstract [sv]

    Bakgrund

    Den här rapporten är en del av Folkhälsomyndighetens uppföljning av arbetet med hivprevention samt sexuell och reproduktiv hälsa och rättigheter (SRHR) bland unga och unga vuxna. Arbetet utgår från regeringens proposition Nationell strategi mot hiv och aids och vissa andra smittsamma sjukdomar och genomfördes inom ramen för Nationell handlingsplan för klamydiaprevention 2009–2014.

    Metod

    Kartläggningen är en textbaserad granskning av högre utbildning till arbetsterapeut, barnmorska, fysioterapeut, jurist, läkare, polis, psykolog, sjuksköterska och socionom. En gemensam nämnare för de olika utbildningar som ingår är att de alla förbereder den studerande för ett självständigt arbete av människo- eller rättsvårdande karaktär där den professionella möter människor i olika livssituationer. Granskningen omfattade yrkesbeskrivningar, utbildningsplaner och kursplaner på 93 utbildningsprogram vid 27 högskolor och universitet i Sverige. Vid granskningen gjordes en kategorisering av utbildningarnas innehåll utifrån indikatorer som relaterar till SRHR-området. Indikatorerna togs fram med stöd av en referensgrupp.

    Resultat och slutsats

    Resultatet visar att hivprevention och SRHR sällan förekommer i yrkesbeskrivningar, utbildningsplaner och kursplaner på de utbildningar som undersökts. Detta kan leda till att studenter inte får med sig relevanta kunskaper. Det finns särskilt lite indikatorer för SRHR inom universitets och högskolors professionsutbildningar till: sjuksköterska, socionom, jurist, polis, psykolog samt arbetsterapeut och fysioterapeut. Barnmorska och läkare har fler indikatorer inom SRHR än övriga utbildningar som studerats men trots det är områden som: sex mot sin vilja, hedersrelaterat våld, sex mot ersättning och heteronormen inte alls förekommande samt att området sexuellt våld är mycket lite belyst.

    I förlängningen kan detta leda till kompetensbrist kring sexualitetsområdet och dess betydelse för hälsan. Det kan också försvåra förståelsen för klienters och patienters behov och rättigheter. Högskolor och universitet bör se resultaten som underlag för fortsatt utvecklingsarbete av yrkesutbildningarna. Studenter behöver få möjlighet att i sin kommande yrkesroll stödja alla människors rätt att uppnå sexuell och reproduktiv hälsa och rättigheter oavsett kön, ålder, sexuell läggning, könsidentitet, funktionalitet, socioekonomisk position, etnicitet, kulturell bakgrund och juridisk status.

  • Wallis, Lee
    et al.
    Hasselberg, Marie
    Barkman, Catharina
    Bogoch, Isaac
    Broomhead, Sean
    Dumont, Guy
    Groenewald, Johann
    Lundin, Johan
    Bergendahl, Johan Norell
    Nyasulu, Peter
    Olofsson, Maud
    Weinehall, Lars
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Laflamme, Lucie
    A roadmap for the implementation of mHealth innovations for image-based diagnostic support in clinical and public-health settings: a focus on front-line health workers and health-system organizations2017In: Global Health Action, ISSN 1654-9716, E-ISSN 1654-9880, Vol. 10, 1340254Article in journal (Refereed)
    Abstract [en]

    Background: Diagnostic support for clinicians is a domain of application of mHealth technologies with a slow uptake despite promising opportunities, such as image-based clinical support. The absence of a roadmap for the adoption and implementation of these types of applications is a further obstacle. Objectives: This article provides the groundwork for a roadmap to implement image-based support for clinicians, focusing on how to overcome potential barriers affecting front-line users, the health-care organization and the technical system. Methods: A consensual approach was used during a two-day roundtable meeting gathering a convenience sample of stakeholders (n = 50) from clinical, research, policymaking and business fields and from different countries. A series of sessions was held including small group discussions followed by reports to the plenary. Session moderators synthesized the reports in a number of theme-specific strategies that were presented to the participants again at the end of the meeting for them to determine their individual priority. Results: There were four to seven strategies derived from the thematic sessions. Once reviewed and prioritized by the participants some received greater priorities than others. As an example, of the seven strategies related to the front-line users, three received greater priority: the need for any system to significantly add value to the users; the usability of mHealth apps; and the goodness-of-fit into the work flow. Further, three aspects cut across the themes: ease of integration of the mHealth applications; solid ICT infrastructure and support network; and interoperability. Conclusions: Research and development in image-based diagnostic pave the way to making health care more accessible and more equitable. The successful implementation of those solutions will necessitate a seamless introduction into routines, adequate technical support and significant added value.

  • Gnanasundram, Sivakumar Vadivel
    et al.
    Pyndiah, Slovenie
    Daskalogianni, Chrysoula
    Armfield, Kate
    Nylander, Karin
    Umeå University, Faculty of Medicine, Department of Medical Biosciences.
    Wilson, Joanna B.
    Fåhraeus, Robin
    Umeå University, Faculty of Medicine, Department of Medical Biosciences. Inserm UMRS1162, Equipe Labellisée la Ligue Contre le Cancer, Institut de Génétique Moléculaire, Université Paris 7, Hôpital St. Louis, 75010, Paris, France; RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 65653, Brno, Czech Republic.
    PI3Kδ delta activates E2F1 synthesis in response to mRNA translation stress2017In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, 2103Article in journal (Refereed)
    Abstract [en]

    The c-myc oncogene stimulates ribosomal biogenesis and protein synthesis to promote cellular growth. However, the pathway by which cells sense and restore dysfunctional mRNA translation and how this is linked to cell proliferation and growth is not known. We here show that mRNA translation stress in cis triggered by the gly-ala repeat sequence of Epstein–Barr virus (EBV)-encoded EBNA1, results in PI3Kδ-dependent induction of E2F1 mRNA translation with the consequent activation of c-Myc and cell proliferation. Treatment with a specific PI3Kδ inhibitor Idelalisib (CAL-101) suppresses E2F1 and c-Myc levels and causes cell death in EBNA1-induced B cell lymphomas. Suppression of PI3Kδ prevents E2F1 activation also in non-EBV-infected cells. These data illustrate an mRNA translation stress–response pathway for E2F1 activation that is exploited by EBV to promote cell growth and proliferation, offering new strategies to treat EBV-carrying cancers.

  • Barkman, Catharina
    et al.
    Weinehall, Lars
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Policymakers and mHealth: roles and expectations, with observations from Ethiopia, Ghana and Sweden2017In: Global Health Action, ISSN 1654-9716, E-ISSN 1654-9880, Vol. 10, 1337356Article in journal (Refereed)
    Abstract [en]

    The rapid increase in mobile phone use and other telecommunication technologies in health care during the past decade has paved the way for optimism. mHealth (mobile health) initiatives need to be integrated into national health systems and priorities and fit into the system that the country has already invested in. Partnership between government, regional governments, health care systems, Community Health Workers, the private sector and universities is considered as a precondition for success. In turn, this requires strategic and integrative policy decisions on the national/regional level to be defined in the action plans as concrete steps. Decision makers are calling for scale-up plans to be in place even in the pilot phases. Hope is expressed that the initial joy and curiosity that new technology generates in the implementation phase will be transferred to routine work. Standards and a common technical architecture that enables interoperability and upscaling are key issues. Based on publications on policy and national strategies, this paper highlights some key areas for decision makers' role and expectations with regard to mHealth. The paper will also report some mHealth experiences from Ethiopia, Ghana and Sweden.

  • Mishra, Yogesh
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC).
    Hall, Michael
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Locmelis, Roland
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Nam, Kwangho
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, 76019-0065, USA.
    Söderberg, Christopher A. G.
    Storm, Patrik
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Chaurasia, Neha
    Rai, Lal Chand
    Jansson, Stefan
    Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC).
    Schröder, Wolfgang P.
    Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Sauer, Uwe H.
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
    Active-site plasticity revealed in the asymmetric dimer of AnPrx6 the 1-Cys peroxiredoxin and molecular chaperone from Anabaena sp. PCC 72102017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 17151Article in journal (Refereed)
    Abstract [en]

    Peroxiredoxins (Prxs) are vital regulators of intracellular reactive oxygen species levels in all living organisms. Their activity depends on one or two catalytically active cysteine residues, the peroxidatic Cys (C-P) and, if present, the resolving Cys (C-R). A detailed catalytic cycle has been derived for typical 2-Cys Prxs, however, little is known about the catalytic cycle of 1-Cys Prxs. We have characterized Prx6 from the cyanobacterium Anabaena sp. strain PCC7120 (AnPrx6) and found that in addition to the expected peroxidase activity, AnPrx6 can act as a molecular chaperone in its dimeric state, contrary to other Prxs. The AnPrx6 crystal structure at 2.3 angstrom resolution reveals different active site conformations in each monomer of the asymmetric obligate homo-dimer. Molecular dynamic simulations support the observed structural plasticity. A FSH motif, conserved in 1-Cys Prxs, precedes the active site PxxxTxxCp signature and might contribute to the 1-Cys Prx reaction cycle.

  • Sarneel, J. M. Judith
    et al.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences. Ecology & Biodiversity Group and Plant Ecophysiology Group, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
    Veen, G. F. Ciska
    Legacy effects of altered flooding regimes on decomposition in a boreal floodplain2017In: Plant and Soil, ISSN 0032-079X, E-ISSN 1573-5036, Vol. 421, no 1-2, 57-66 p.Article in journal (Refereed)
    Abstract [en]

    Since long-term experiments are scarce, we have poor understanding of how changed flooding regimes affect processes such as litter decomposition. We simulated short- and long-term changed flooding regimes by transplanting turfs between low (frequently flooded) and high (in-frequently flooded) elevations on the river bank in 2000 (old turfs) and 2014 (young turfs). We tested how incubation elevation, turf origin and turf age affected decomposition of standard litter (tea) and four types of local litter. For tea, we found that the initial decomposition rate (k) and stabilization (S) of labile material during the second decomposition phase were highest at high incubation elevation. We found intermediate values for k and S in young transplanted turfs, but turf origin was not important in old turfs. Local litter mass loss was generally highest at high incubation elevations, and effects of turf origin and turf age were litter-specific. We conclude that incubation elevation, i.e., the current flooding regime, was the most important factor driving decomposition. Soil origin (flooding history) affected decomposition of tea only in young turfs. Therefore, we expect that changes in flooding regimes predominantly affect decomposition directly, while indirect legacy effects are weaker and litter- or site-specific.

  • Public defence: 2018-02-02 13:00 Insikten, Portalen, Skövde
    Bäckström, Caroline A.
    Jönköping University, School of Health and Welfare, HHJ. CHILD.
    Professional and social support for first-time mothers and partners during childbearing2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Background: Expecting a child and becoming a parent is one of life’s major events, during which the parents’ perspective on life and their couple relationship changes. For some parents, childbearing entails a decrease in parental couple relationship quality. The way in which parents are able to cope with childbearing may be connected with their Sense of Coherence; which is a person’s ability to perceive life as comprehensible, manageable and meaningful. For parents’ positive childbearing experiences, professional and social support have been proven to be valuable. However, far from all parents have access to social support; furthermore, professional support does not always meet the needs of expectant parents. Hence, more research is needed to increase knowledge about expectant parents’ experiences of professiona land social support. In addition, more research is needed to explore factors associated with quality of couple relationship among parents during childbearing.

    Aims: The overall aim of the thesis was to explore professional and social support for first-time mothers and partners during childbearing in relation toquality of couple relationship and Sense of Coherence.

    Methods: The study’s designs were explorative, prospective and longitudinal; both qualitative and quantitative methods were used. Specifically, explorative designs, qualitative methods and phenomenographic analysis were used to explore expectant first-time mothers’ (I) and partners’ perceptions of professional support (II). Furthermore, an explorative design, qualitative method and qualitative content analysis were used to explore expectant first-time mothers’ experiences of social support (III). Within Study IV, a prospective longitudinal design, descriptive statistics, non-parametric tests and multiple linear regression analysis were used to evaluate factors associated with quality of couple relationship among first-time mothers and partners, during pregnancy and the first six months of parenthood.

    Results: The overall results of the thesis revealed both similarities and differences between expectant first-time mothers’ and partners’ perceptions of professional support, effects from social support and associated factors with perceived quality of couple relationship. The similarities were; both mothers and partners perceived that professional support could facilitate partner involvement, influence their couple relationship and facilitate contacts with other expectant parents. According to first-time mothers’ experiences, their couple relationship with their partner was also strengthened by social support during pregnancy. Further, the results showed that both first-time mothers’ and partners’ higher perceived couple relationship quality six months after birth, was associated with their higher perceived social support. The results showed also that both mothers and partners perceived their quality of couple relationship to decrease and Sense of Coherence to increase six months after childbirth, compared to the pregnancy. Differences revealed were such as: higher Sense of Coherence was only associated with mothers’ higher perceived quality of couple relationship, and first-time mothers reported perceiving more social support compared to the partners both during pregnancy, first week and six months after childbirth.

    Conclusions: Professional and social support can strengthen first-time mothers and partners both individually and as a couple, in their abilities to cope with childbearing. On the individual basis, the expectant parents could be strengthened through professional and social support that contributed to their understanding and feeling of being prepared for childbirth and parenting, for instance. As a couple, the parents were strengthened by professional support that included the partner’s role, as well as higher perceived social support overall. In contrast, lack of support could have a negative influence on the expectant parents’ feeling of being prepared for childbirth and parenting. Besides this, the results indicates that childbearing has a positive effect on parents’ abilities to cope with life even though their quality of couple relationship decrease. Professionals can use these results in their further understanding about how to offer satisfactory support to first-time mothers and partners during childbearing.

  • Aaboud, M.
    et al.
    Université Mohamed Premier, Faculté des Sciences; LPTPM, Oujda.
    Bergeås, Elin Kuutmann
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Maddocks, H.J.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander K
    DESY, Hamburg and Zeuthen.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel Smith, Camila
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    De Bruin, Pedro Sales
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva.
    Studies of Z gamma production in association with a high-mass dijet system in pp collisions at root s=8 TeV with the ATLAS detector2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 107Article in journal (Refereed)
    Abstract [en]

    The production of a Z boson and a photon in association with a high-mass dijet system is studied using 20.2 fb(-1) of proton-proton collision data at a centre-of-mass energy of root s = 8TeV recorded with the ATLAS detector in 2012 at the Large Hadron Collider. Final states with a photon and a Z boson decaying into a pair of either electrons, muons, or neutrinos are analysed. Electroweak and total pp -> Z gamma jj cross-sections are extracted in two fiducial regions with different sensitivities to electroweak production processes. Quartic couplings of vector bosons are studied in regions of phase space with an enhanced contribution from pure electroweak production, sensitive to vector-boson scattering processes VV -> Z gamma. No deviations from Standard Model predictions are observed and constraints are placed on anomalous couplings parameterized by higher-dimensional operators using effective field theory.

  • Krzyzanowska, Natalia
    Örebro University, School of Humanities, Education and Social Sciences. Chair of Sociology and Philosophy, The Poznań University of Economics and Business, Poland.
    (Counter)Monuments and (Anti)Memory in the City. An Aesthetic and Socio-Theoretical Approach2017In: The Polish Journal of Aesthetics, ISSN 1643-1243, Vol. 47, no 4, 109-128 p.Article in journal (Refereed)
    Abstract [en]

    This article reflects upon the possibility of the visualisation of different forms of collective memory in the city. It focuses on the evolution of the ways of commemorating in public spaces. It juxtaposes traditional monuments erected in commemoration of an event or an "important" person for a community with (counter)monuments as a modern, critical reaction geared towards what is either ignored in historical narratives or what remains on the fringe of collective memory. While following a theoretical exploration of the concepts of memory and their fruition in monuments as well as (counter)monuments, the eventual multimodal analysis central to the paper looks in-depth at Ruth Beckermann’s work The Missing Image (Vienna, 2015). The latter is treated as an example of the possible and manifold interpretations of the function and multiplicity of meanings that (counter)-monuments bring to contemporary urban spaces.

  • Bergman, Mats
    et al.
    Södertörn University, School of Social Sciences, Economics.
    Felländer, Anna
    KTH.
    Åsbrink, Erik
    Handelns betydelse: då, nu och i framtiden2017Report (Other (popular science, discussion, etc.))
  • Gottfridsson, Patrik
    Karlstad University, Faculty of Economic Sciences, Communication and IT, Department of Business Administration. Karlstad University, Faculty of Economic Sciences, Communication and IT, The Service and Market Oriented Transport Research Group.
    BIMS-projektets startfas: Dokumentation från följeforskning2011Report (Other academic)
  • Dorafshan, Eshagh
    et al.
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Kahn, Tatyana G.
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Schwartz, Yuri B.
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Hierarchical recruitment of Polycomb complexes revisited2017In: Nucleus, ISSN 1949-1034, E-ISSN 1949-1042, Vol. 8, no 5, 496-505 p.Article in journal (Refereed)
    Abstract [en]

    Polycomb Group (PcG) proteins epigenetically repress key developmental genes and thereby control alternative cell fates. PcG proteins act as complexes that can modify histones and these histone modifications play a role in transmitting the memory of the repressed state as cells divide. Here we consider mainstream models that link histone modifications to hierarchical recruitment of PcG complexes and compare them to results of a direct test of interdependence between PcG complexes for recruitment to Drosophila genes. The direct test indicates that PcG complexes do not rely on histone modifications to recognize their target genes but use them to stabilize the interactions within large chromatin domains. It also shows that multiple strategies are used to coordinate the targeting of PcG complexes to different genes, which may make the repression of these genes more or less robust.

  • Hjorth, Elisabeth
    University College of Arts, Crafts and Design, Institutionen för Konst (K).
    Imagination and Artistic Research or how to make matters worse2017Conference paper (Other academic)
  • Hjorth, Elisabeth
    University College of Arts, Crafts and Design, Institutionen för Konst (K).
    Att skriva mellan förtvivlan och skönhet2015In: Ord och bild, ISSN 0030-4492, E-ISSN 1402-2508, no 5, 5-14 p.Article in journal (Other academic)
  • Hjorth, Elisabeth
    University College of Arts, Crafts and Design, Institutionen för Konst (K).
    Sentimentalt2017In: Kritiker : nordisk tidskrift för litterär kritik och essäistik, ISSN 1653-7432, no 43, 34--39 p.Article in journal (Other academic)
  • Franke, Ulrik
    et al.
    RISE, Swedish ICT, SICS, Software and Systems Engineering Laboratory.
    Ciccozzi, Federico
    Characterization of trade-off preferences between non-functional properties2017Article in journal (Refereed)
    Abstract [en]

    Efficient design and evolution of complex software intensive systems rely on the ability to make informed decisions as early as possible in the life cycle. Such informed decisions should take both the intended functional and non-functional properties into account. Especially regarding the latter, it is both necessary to be able to predict properties and to prioritize them according to well-defined criteria. In this paper we focus on the latter problem, that is to say how to make trade-offs between non-functional properties of software intensive systems. We provide an approach based on the elicitation of utility functions from stake-holders and subsequent checks for consistency among these functions. The approach is exploitable through an easy-to-use GUI, which is also presented. Moreover, we describe the setup and the outcome of our two-fold validation based on exploratory elicitations with students and practitioners

  • Lawler, Katherine
    et al.
    Kings Coll London, Sch Canc Studies, CRUK Kings Hlth Partners Ctr, Guys Campus, London SE1 1UL, England.;Kings Coll London, Ins Math & Mol Biomed, Hodgkin Bldg,Guys Campus, London SE1 1UL, England..
    Papouli, Efterpi
    Guys & St Thomas NHS Fdn Trust, NIHR Comprehens Biomed Res Ctr, London WC2R 2LS, England.;Kings Coll London, London WC2R 2LS, England..
    Naceur-Lombardelli, Cristina
    Kings Coll London, Guys Hosp, Res Oncol, Fac Life Sci & Med, London SE1 9RT, England..
    Mera, Anca
    Kings Coll London, Guys Hosp, Res Oncol, Fac Life Sci & Med, London SE1 9RT, England.;Kings Coll London, Guys Hosp, Canc Epidemiol Unit, London SE1 9RT, England..
    Ougham, Kayleigh
    Kings Coll London, Guys Hosp, Canc Bioinformat, Innovat Ctr,Canc Ctr, London SE1 9RT, England..
    Tutt, Andrew
    Kimbung, Siker
    Kings Coll London, Breast Canc Now Res Unit, Kings Hlth Partners AHSC, Canc Ctr,Guys Hosp,Innovat Ctr,Fac Life Sci & Med, London SE1 9RT, England.;Lund Univ, Div Oncol & Pathol, Dept Clin Sci, Lund, Sweden.;Lund Univ, CREATE Hlth Strateg Ctr Translat Canc Res, Lund, Sweden..
    Hedenfalk, Ingrid
    Kings Coll London, Breast Canc Now Res Unit, Kings Hlth Partners AHSC, Canc Ctr,Guys Hosp,Innovat Ctr,Fac Life Sci & Med, London SE1 9RT, England.;Lund Univ, Div Oncol & Pathol, Dept Clin Sci, Lund, Sweden.;Lund Univ, CREATE Hlth Strateg Ctr Translat Canc Res, Lund, Sweden..
    Zhan, Jun
    Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China.;Peking Univ, Dept Anat Histol & Embryol, Lab Mol Cell Biol & Tumor Biol, Hlth Sci Ctr, Beijing, Peoples R China..
    Zhang, Hongquan
    Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China.;Peking Univ, Dept Anat Histol & Embryol, Lab Mol Cell Biol & Tumor Biol, Hlth Sci Ctr, Beijing, Peoples R China..
    Buus, Richard
    Inst Canc Res, Breast Canc Now Toby Robins Res Ctr, London, England..
    Dowsett, Mitch
    Inst Canc Res, Breast Canc Now Toby Robins Res Ctr, London, England..
    Ng, Tony
    Kings Coll London, Sch Canc Studies, CRUK Kings Hlth Partners Ctr, Guys Campus, London SE1 1UL, England.;Kings Coll London, Richard Dimbleby Dept Canc Res, Randall Div Cell & Mol Biophys, Guys Campus, London SE1 1UL, England.;UCL, UCL Canc Inst, Paul OGorman Bldg, London WC1E 6DD, England..
    Pinder, Sarah E.
    Kings Coll London, Guys Hosp, Res Oncol, Fac Life Sci & Med, London SE1 9RT, England..
    Parker, Peter
    Kings Coll London, Sch Canc Studies, CRUK Kings Hlth Partners Ctr, Guys Campus, London SE1 1UL, England.;London Res Inst, Lincolns Inn Fields, London WC2A 3LY, England..
    Holmberg, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery. Kings Coll London, Guys Hosp, Canc Epidemiol Unit, London SE1 9RT, England.
    Gillett, Cheryl E.
    Kings Coll London, Guys Hosp, Res Oncol, Fac Life Sci & Med, London SE1 9RT, England..
    Grigoriadis, Anita
    Kings Coll London, Sch Canc Studies, CRUK Kings Hlth Partners Ctr, Guys Campus, London SE1 1UL, England.;Kings Coll London, Guys Hosp, Res Oncol, Fac Life Sci & Med, London SE1 9RT, England.;Kings Coll London, Guys Hosp, Canc Bioinformat, Innovat Ctr,Canc Ctr, London SE1 9RT, England..
    Purushotham, Arnie
    Kings Coll London, Sch Canc Studies, CRUK Kings Hlth Partners Ctr, Guys Campus, London SE1 1UL, England.;Kings Coll London, Guys Hosp, Res Oncol, Fac Life Sci & Med, London SE1 9RT, England..
    Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study2017In: Breast Cancer Research, ISSN 1465-5411, E-ISSN 1465-542X, Vol. 19, 113Article in journal (Refereed)
    Abstract [en]

    Background: Metastases from primary breast cancers can involve single or multiple organs at metastatic disease diagnosis. Molecular risk factors for particular patterns of metastastic spread in a clinical population are limited.

    Methods: A case-control design including 1357 primary breast cancers was used to study three distinct clinical patterns of metastasis, which occur within the first six months of metastatic disease: bone and visceral metasynchronous spread, bone-only, and visceral-only metastasis. Whole-genome expression profiles were obtained using whole genome (WG)-DASL assays from formalin-fixed paraffin-embedded (FFPE) samples. A systematic protocol was developed for handling FFPE samples together with stringent data quality controls to identify robust expression profiling data. A panel of published and novel gene sets were tested for association with these specific patterns of metastatic spread and odds ratios (ORs) were calculated.

    Results: Metasynchronous metastasis to bone and viscera was found in all intrinsic breast cancer subtypes, while immunohistochemically (IHC)-defined receptor status and specific IntClust subgroups were risk factors for visceral-only or bone-only first metastases. Among gene modules, those related to proliferation increased the risk of metasynchronous metastasis (OR (95% CI) = 2.3 (1.1-4.8)) and visceral-only first metastasis (OR (95% CI) = 2.5 (1.2-5.1)) but not bone-only metastasis (OR (95% CI) = 0.97 (0.56-1.7)). A 21-gene module (BV) was identified in estrogen-receptor-positive breast cancers with metasynchronous metastasis to bone and viscera (area under the curve = 0.77), and its expression increased the risk of bone and visceral metasynchronous spread in this population. BV was further orthogonally validated with NanoString nCounter in primary breast cancers, and was reproducible in their matched lymph nodes metastases and an external cohort.

    Conclusion: This case-control study of WG-DASL global expression profiles from FFPE tumour samples, after careful quality control and RNA selection, revealed that gene modules in the primary tumour have differing risks for clinical patterns of metasynchronous first metastases. Moreover, a novel gene module was identified as a putative risk factor for metasynchronous bone and visceral first metastatic spread, with potential implications for disease monitoring and treatment planning.

  • Schaffernicht, Erik
    et al.
    Örebro University, School of Science and Technology.
    Hernandez Bennetts, Victor
    Örebro University, School of Science and Technology.
    Lilienthal, Achim
    Örebro University, School of Science and Technology.
    Mobile robots for learning spatio-temporal interpolation models in sensor networks - The Echo State map approach: The Echo State map approach2017In: 2017 IEEE International Conference on Robotics and Automation (ICRA), Institute of Electrical and Electronics Engineers (IEEE), 2017, 2659-2665 p.Conference paper (Refereed)
    Abstract [en]

    Sensor networks have limited capabilities to model complex phenomena occuring between sensing nodes. Mobile robots can be used to close this gap and learn local interpolation models. In this paper, we utilize Echo State Networks in order to learn the calibration and interpolation model between sensor nodes using measurements collected by a mobile robot. The use of Echo State Networks allows to deal with temporal dependencies implicitly, while the spatial mapping with a Gaussian Process estimator exploits the fact that Echo State Networks learn linear combinations of complex temporal dynamics. The resulting Echo State Map elegantly combines spatial and temporal cues into a single representation. We showcase the method in the exposure modeling task of building dust distribution maps for foundries, a challenge which is of great interest to occupational health researchers. Results from simulated data and real world experiments highlight the potential of Echo State Maps. While we focus on particulate matter measurements, the method can be applied for any other environmental variables like temperature or gas concentration.