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  • Hollander, Ernst
    University of Gävle, Faculty of Education and Business Studies, Department of Business and Economic Studies, Business administration.
    The contemporary relevance of Karl Polanyi – a Swedish case2017In: Theory and Method of Evolutionary Political Economy: A Cyprus Symposium / [ed] Hardy Hanappi, Savvas Katsikides, Manuel Scholz-Wäckerle, Abingdon: Routledge, 2017, 54-72 p.Chapter in book (Refereed)
  • Gauffin, Emelie
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital. Linkoping Univ, Burn Ctr, Dept Hand Plast & Intens, S-58185 Linkoping, Sweden..
    Öster, Caisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Sjöberg, Folke
    Linkoping Univ, Burn Ctr, Dept Hand Plast & Intens, S-58185 Linkoping, Sweden..
    Gerdin, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Plastic Surgery.
    Ekselius, Lisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Health-related quality of life (EQ-5D) early after injury predicts long-term pain after burn2016In: Burns, ISSN 0305-4179, E-ISSN 1879-1409, Vol. 42, no 8, 1781-1788 p.Article in journal (Refereed)
    Abstract [en]

    Background: Chronic pain after burn can have severe physical and psychological effects on former patients years after the initial injury. Although the issue of pain after burn has gained increased attention over the past years, prospective, longitudinal studies are scarce. Our aim was to prospectively investigate consecutive burn patients for pain severity over time and to evaluate the prevalence and characteristics of post-burn pain to 2-7 years after the burn. As an additional aim, the effects of burn and individual-related factors, especially health related Quality of Life (HRQoL), were investigated.

    Method: Sixty-seven consecutive burn patients were assessed during acute care at 3, 6, 12 and 24 months, as well as at 2-7 years post-burn. HRQoL, symptoms of post-traumatic stress disorder (PTSD) and other psychiatric disorders were investigated. During the interviews that took place 2-7 years after the injury (mean 4.6 1.9 years), current chronic post-burn pain was assessed using the Brief Pain Inventory-Short Form (BPI-SF).

    Results: One-third of the patients still reported pain 2-7 years after the injury. Pain severity and interference with daily life were mainly mild to moderate though they were found to be associated with significantly lower HRQoL. Chronic pain after bum was associated with both burn- and individual-related factors. In logistic regression analysis HRQoL at 3 and 12 months and symptoms of PTSD at 12 months were independent factors in predicting chronic pain after burn.

    Conclusion: Pain after burn becomes a chronic burden for many former burn patients and decreases HRQoL. A novel finding in this study was that HRQoL assessed early after burn was a predictor for the development of chronic pain. This finding may help to predict future pain problems and serve as an indicator for pain preventive measures.

  • Aaboud, M.
    et al.
    Bergeaas Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gardin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel Smith, Camila
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Measurement of the Inelastic Proton-Proton Cross Section at root s=13 TeV with the ATLAS Detector at the LHC2016In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 117, no 18, 182002Article in journal (Refereed)
    Abstract [en]

    This Letter presents a measurement of the inelastic proton-proton cross section using 60 mu b(-1) of pp collisions at a center-of-mass energy root s of 13 TeV with the ATLAS detector at the LHC. Inelastic interactions are selected using rings of plastic scintillators in the forward region (2.07 <vertical bar eta vertical bar < 3.86) of the detector. A cross section of 68.1 +/- 1.4 mb is measured in the fiducial region. xi = M-X(2) > s > 10(-6), where M-X is the larger invariant mass of the two hadronic systems separated by the largest rapidity gap in the event. In this xi range the scintillators are highly efficient. For diffractive events this corresponds to cases where at least one proton dissociates to a system with M-X > 13 GeV. The measured cross section is compared with a range of theoretical predictions. When extrapolated to the full phase space, a cross section of 78.1 +/- 2.9 mb is measured, consistent with the inelastic cross section increasing with center-of-mass energy.

  • Aad, G.
    et al.
    Bergeås, Elin Kuutmann
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isaksson, Charlie
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Pelikan, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Measurement of fiducial differential cross sections of gluon-fusion production of Higgs bosons decaying to WW (au)-> e nu mu nu with the ATLAS detector at TeV2016In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 8, 104Article in journal (Refereed)
    Abstract [en]

    This paper describes a measurement of fiducial and differential cross sections of gluon-fusion Higgs boson production in the H -> W W (au)-> e nu mu nu channel, using 20.3 fb(-1) of proton-proton collision data. The data were produced at a centre-of-mass energy of TeV at the CERN Large Hadron Collider and recorded by the ATLAS detector in 2012. Cross sections are measured from the observed H -> W W (au)-> e nu mu nu signal yield in categories distinguished by the number of associated jets. The total cross section is measured in a fiducial region defined by the kinematic properties of the charged leptons and neutrinos. Differential cross sections are reported as a function of the number of jets, the Higgs boson transverse momentum, the dilepton rapidity, and the transverse momentum of the leading jet. The jet-veto efficiency, or fraction of events with no jets above a given transverse momentum threshold, is also reported. All measurements are compared to QCD predictions from Monte Carlo generators and fixed-order calculations, and are in agreement with the Standard Model predictions.

  • Costa Paiva, Sofia
    et al.
    University of Sao Paolo, São Carlos, Brazil.
    Simao, Adenilso
    University of Sao Paolo, São Carlos, Brazil.
    Varshosaz, Mahsa
    Halmstad University, School of Information Technology, Halmstad Embedded and Intelligent Systems Research (EIS), Centre for Research on Embedded Systems (CERES).
    Mousavi, Mohammad Reza
    Halmstad University, School of Information Technology, Halmstad Embedded and Intelligent Systems Research (EIS), Centre for Research on Embedded Systems (CERES).
    Complete IOCO Test Cases: A Case Study2016In: A-TEST 2016 - Proceedings of the 7th International Workshop on Automating Test Case Design, Selection, and Evaluation, co-located with FSE 2016, New York, NY: ACM Press, 2016, 38-44 p.Conference paper (Refereed)
    Abstract [en]

    Input/Output Transition Systems (IOTSs) have been widely used as test models in model-based testing. Traditionally, input output conformance testing (IOCO) has been used to generate random test cases from IOTSs. A recent test case generation method for IOTSs, called Complete IOCO, applies fault models to obtain complete test suites with guaranteed fault coverage for IOTSs. This paper measures the efficiency of Complete IOCO in comparison with the traditional IOCO test case generation implemented in the JTorX tool. To this end, we use a case study involving five specification models from the automotive and the railway domains. Faulty mutations of the specifications were produced in order to compare the efficiency of both test generation methods in killing them. The results indicate that Complete IOCO is more efficient in detecting deep faults in large state spaces while IOCO is more efficient in detecting shallow faults in small state spaces. © 2016 ACM.

  • Nilsson, Peter
    et al.
    Volvo GTT.
    Laine, Leo
    Volvo GTT.
    Sandin, Jesper
    Swedish National Road and Transport Research Institute, Traffic and road users, Förare och fordon, FOF.
    High speed control of long combination heavy commercial vehicles within safe corridors2016Report (Other academic)
    Abstract [en]

    The main scope of the project was to initiate a technical framework for studying manual and automated high-speed driving of long vehicle combinations (LVCs) in a driving simulator environment.

    The project included implementation and evaluation of vehicle models representing a rigid truck solo (reference vehicle) and an A-double LVC in VTI driving simulator IV (Sim IV). The A-double combination consisted of a 6x4 tractor unit followed by a three-axle semi-trailer, two-axle converter dolly and a second three-axle semi-trailer unit. The total vehicle length of the A-double was 32 metres and the total weight was set to 80 tonnes. The implementation of the vehicle models was evaluated by drivers from Volvo product development. The evaluation was carried out during normal driving conditions, with speeds ranging from 0 to 90 km/h.

    Besides the implementation and evaluation of vehicle models, the project also included a driving simulator study in which manual and automated driving of the A-double have been studied. The participants in the study were 12 professional truck drivers from a haulage contractor and 8 drivers from Volvo product development. The driving scenario consisted of a relatively curvy and hilly single-lane Swedish county road (Road 180), without additional road users and safety critical events. Two automated driving strategies for steering, propulsion and braking were formulated, whereof one of the steering strategies included results from an optimal control based receding horizon approach. The drivers’ manual lane keeping and speed profiles were recorded for post-analysis. In addition, the drivers’ subjective acceptance of automated driving trajectories was also collected.

  • Anund, Anna
    et al.
    Swedish National Road and Transport Research Institute, Traffic and road users, Trafikanttillstånd, TIL.
    Blissing, Björn
    Swedish National Road and Transport Research Institute, Traffic and road users, Körsimulering och visualisering, SIM.
    Saluäär, Dennis
    Volvo AB.
    Svanberg, Bo
    Volvo Car Corporation.
    Ljung Aust, Mikael
    Volvo Car Corporation.
    Holmertz, Pontus
    HiQ.
    Night-time scenarios in simulators: a prestudy of needs, knowledge and possible solutions2016Report (Other academic)
    Abstract [en]

    The study in this publication investigates the need and potential for night-time scenarios in driving simulators, determines how such night-time scenarios could be reproduced and identifies the objects most important to reproduce. Although on average 12 out of every 24 hours are dark and considering that most situations are more demanding for drivers in dark conditions, simulations of driving scenarios with different degrees of darkness are not common. The project work comprised a pre-study that involved an investigation of the need and potential of night-time scenarios with the help of input from different stakeholders, consolidation of what is known up to now through benchmarking and state of the art, and a review of available technical solutions. The objective was to identify pros and cons with existing solutions and aspects that are important to consider in order to reproduce the most important components in realistic night-time scenarios. Based on the results, six important use cases were identified and two of these (‘Driver fatigue’ and ‘Objects without light sources’) were studied in more detail. It was concluded that for night-time scenarios there is enough darkness in general in the simulator environment. The question is whether it is possible to create sufficient contrast for objects that are meant to be observable. For daytime scenarios, the light levels in the simulator are clearly unrealistically low and this limitation might even trigger unwanted sleepiness.

  • Zink, Eren
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Cultural Anthropology and Ethnology.
    Research training, international collaboration, and the agencies of Ugandan scientists in Uganda2016In: North–South Knowledge Networks: Towards equitable collaboration between academics, donors and universities / [ed] Tor Halvorsen and Jorun Nossum, Cape Town: African Minds, 2016, 57-84 p.Chapter in book (Refereed)
  • Kroik, David
    Umeå University, Faculty of Arts, Department of language studies.
    Differential object marking in South Saami2016Licentiate thesis, monograph (Other academic)
    Abstract [en]

    This licentiate thesis investigates the case and the syntactic position of the direct object in South Saami. The focus is on plural direct objects, which have Differential Object Marking, a phenomenon in which the case alternates between different types of direct objects. In South Saami, some direct objects carry the accusative case form in the plural, while others only carry the plural marker. This variation of suffix displayed on the direct object is contingent on definiteness; definite direct objects consistently display the accusative case form in the plural while indefinite direct objects, specific and nonspecific alike, lack accusative morphology. In addition to case marking, the study presents an analysis of the alternation of the syntactic position of some direct objects. Definite and indefinite specific direct objects can be realized in two positions: as the complement of the verb or in a position as specifier of the light verb projection. By contrast, indefinite nonspecific direct objects obligatorily surface in the complement position of the verb. This variability in syntactic position of some direct objects is analyzed by means of a Specificity Operator, adjoined to the DP-level of every specific NP, definite and indefinite. The operator moves as an instance of quantifier raising in order to take scope over Existential Closure (EC). EC binds NPs in its domain and give them an existential reading. Therefore, when the Specificity Operator raises, it anchors the DP it is adjoined to in a domain, which is unbound by EC and therefore facilitates a specific interpretation. The operator, void of phonological content, can raise alone to the specifier of vP as an instance of covert movement. The operator can also Pied-pipe the DP it is adjoined to, which results in overt movement of the DP. Indefinite nonspecific direct objects lack the Specificity Operator and therefore they remain in-situ in the VP, where they are bound by EC.

    In addition to its theoretical value, the thesis will be of use for teachers, students and others with an interest in a better understanding of the case form and the position of the direct object in South Saami.

  • Karlsdóttir, Anna
    et al.
    Nordic Council of Ministers, Nordregio.
    Greve Harbo, Lisbeth
    Nordic Council of Ministers, Nordregio.
    Nordic Arctic Strategies in Overview2017Other (Other (popular science, discussion, etc.))
    Abstract [en]

    During the last decade, all Nordic countries have drawn up strategies for their Artic regions, with several countries even revising these Arctic strategies within this short period of time. It shows that the Arctic region has become a matter of higher political interest; not only at national level, where the focus has shifted from seeing the individual Arctic regions as general development areas to regions with geographic specificities that deserve particular attention at this point in time. The interest does not only lie in the Nordic countries but they are reflecting on other actors’ increased interest in the Arctic region; such as strategies drawn up by other circumpolar countries as well as the reason EU attention towards the Arctic regions. What are the goals and priorities in the Nordic national Arctic strategies?

  • Asiatici, Mikhail
    et al.
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems. The School of Computer and Communication Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
    Laakso, Miku
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Fischer, Andreas
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems. The Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT), 76344 Karlsruhe, Germany.
    Stemme, Göran
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Niklaus, Frank
    Through Silicon Vias With Invar Metal Conductorfor High-Temperature Applications2017In: Journal of microelectromechanical systems, ISSN 1057-7157, E-ISSN 1941-0158, Vol. 26, no 1, 158-168 p.Article in journal (Refereed)
    Abstract [en]

    Through silicon vias (TSVs) are key enablers of 3-D integration technologies which, by vertically stacking andinterconnecting multiple chips, achieve higher performances,lower power, and a smaller footprint. Copper is the mostcommonly used conductor to fill TSVs; however, copper hasa high thermal expansion mismatch in relation to the siliconsubstrate. This mismatch results in a large accumulation ofthermomechanical stress when TSVs are exposed to high temperaturesand/or temperature cycles, potentially resulting in devicefailure. In this paper, we demonstrate 300 μm long, 7:1 aspectratio TSVs with Invar as a conductive material. The entireTSV structure can withstand at least 100 thermal cycles from −50 °C to 190 °C and at least 1 h at 365 °C, limited bythe experimental setup. This is possible thanks to matchingcoefficients of thermal expansion of the Invar via conductor andof silicon substrate. This results in thermomechanical stressesthat are one order of magnitude smaller compared to copperTSV structures with identical geometries, according to finiteelement modeling. Our TSV structures are thus a promisingapproach enabling 2.5-D and 3-D integration platforms for hightemperatureand harsh-environment applications.

  • Nåbo, Arne
    et al.
    Swedish National Road and Transport Research Institute, Traffic and road users, Körsimulering och visualisering, SIM.
    Andhill, Carl Johan
    Dynagraph.
    Blissing, Björn
    Swedish National Road and Transport Research Institute, Traffic and road users, Körsimulering och visualisering, SIM.
    Hjort, Mattias
    Swedish National Road and Transport Research Institute, Traffic and road users, Förare och fordon, FOF.
    Källgren, Laban
    Swedish National Road and Transport Research Institute, Traffic and road users, Körsimulering och visualisering, SIM.
    Known Roads: real roads in simulated environments for the virtual testing of new vehicle systems2016Report (Other academic)
    Abstract [en]

    This publication presents a project aiming to develop virtual representations of real roads for use in driving simulators. The development was done in order to enable assessments of new systems on existing and well known roads in a driving simulator, and will increase the external validity of virtual testing. Furthermore, the usage of the virtual model of such roads makes the simulator results better comparable to earlier performed or later following road tests. The roads connecting Göteborg-Borås-Alingsås-Göteborg were selected. The purpose for this is due to their proximity to the vehicle industry in west Sweden and to the test tracks “Hällered” and “AstaZero”. However, the tools and methods developed can be used to build a virtual representation of any other road through a surrounding landscape and/or more urban environment. The project was carried out in steps, starting with data collection (investigation and assessment of available data from different sources as well as measurement of road properties) followed by data treatment (remove irrelevant data and errors, filtering, etc.), modelling (mathematical description of road properties) and simulation (selection of data formats for real time simulation).

  • Zollbrecht, Christa
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden..
    Persson, A. Erik G.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Lundberg, Jon O.
    Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden..
    Weitzberg, Eddie
    Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden..
    Carlström, Mattias
    Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden..
    Nitrite-mediated reduction of macrophage NADPH oxidase activity is dependent on xanthine oxidoreductase-derived nitric oxide but independent of S-nitrosation2016In: Redox Biology, ISSN 0090-7324, E-ISSN 2213-2317, Vol. 10, 119-127 p.Article in journal (Refereed)
    Abstract [en]

    Background: Inorganic nitrite has shown beneficial effects in cardiovascular and metabolic diseases partly via attenuation of NADPH-oxidase (NOX)-mediated oxidative stress. However, the exact mechanisms are still unclear. Here we investigated the role of S-nitrosation or altered expression of NOX subunits, and the role of xanthine oxidoreductase (XOR) in nitrite-derived nitric oxide (NO) production. Methods: Mouse macrophages were activated with LPS in the presence or absence of nitrite. NOX activity was measured by lucigenin-dependent chemiluminescence. Gene and protein expression of NOX2 subunits and XOR were investigated using qPCR and Western Blot. S-nitrosation of Nox2 and p22phox was studied with a Biotin Switch assay. Uric acid levels in cell culture medium were analyzed as a measure of XOR activity, and NO production was assessed by DAF-FM fluorescence. Results: NOX activity in activated macrophages was significantly reduced by nitrite. Reduced NOX activity was not attributed to decreased NOX gene expression. However, protein levels of p47phox and p67phox subunits were reduced by nitrite in activated macrophages. Protein expression of Nox2 and p22phox was not influenced by this treatment and neither was their S-nitrosation status. Increased uric acid levels after nitrite and diminished NO production during XOR-inhibition with febuxostat suggest that XOR is more active during nitrite-treatment of activated macrophages and plays an important role in the bioactivation of nitrite. Conclusions: Our findings contribute to the mechanistic understanding about the therapeutic effects associated with nitrite supplementation in many diseases. We show that nitrite-mediated inhibition of NOX activity cannot be explained by S-nitrosation of the NOX enzyme, but that changes in NOX2 expression and XOR function may contribute.

  • Public defence: 2017-02-28 09:00 Rudbecksalen, Uppsala
    Manivel, Vivek Anand
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    The role of anti-collagen type II antibodies in the pathogenesis and prognosis of rheumatoid arthritis2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Rheumatoid arthritis (RA) which affects 0.5-1% of the world population and is characterised by joint erosions and presence of the autoantibodies anti-citrullinated protein antibodies (ACPA) and rheumatoid factor. Collagen II (CII) is a joint-specific antigen and we have shown that antibodies against CII (anti-CII) are present in around 8% of RA patients. RA patients with anti-CII are characterized by acute RA onset with elevated CRP and early joint erosions at the time of RA onset. Polymorphonuclear granulocytes (PMN) and peripheral blood mononuclear cells (PBMC) are abundant in RA synovial fluids, where they can interact with anti-CII, thus forming immune complexes (IC) with CII. In my thesis I have shown that PMN upregulated the cell surface markers CD66b and CD11b and downregulated CD16 and CD32 after stimulation with anti-CII IC. These changes in CD66b and CD16 associated to joint erosions to a larger extent than did PBMC responses to anti-CII IC. PMN cocultured with PBMC and stimulated with anti-CII IC showed augmented chemokine production that was dependent on TLR4 and functionally active PMN enzymes. This mechanism can lead to accumulation of inflammatory cells in joints of RA patients who are anti-CII positive around the time of RA diagnosis, and may thus help explain the acute onset RA phenotype associated with anti-CII.

    In a large Swedish RA cohort, anti-CII associated with elevations in clinical and laboratory measures of disease activity at diagnosis and until 6 months, whereas ACPA associated with late inflammation. Anti-CII seropositive RA was associated with improvements in clinical measurements and was negatively associated with smoking in contrast to ACPA that was associated with worseneing of clinical symptoms and associated positively with smoking. Anti-CII levels associated to  HLADRB1*03 and  HLADRB1*01 whereas ACPA showed negative association to HLA-DRB1*03. In a Malaysian RA cohort anti-CII also associated to elevated CRP at the time of diagnosis.

    Anti-CII seropositive RA represents a distinct phenotype, in many respects representing the converse  to the clinical, genetic and smoking associations described for ACPA. Early determinations of anti-CII in parallel to ACPA predict the inflammatory outcome in RA.

  • Petersson, Jöran
    Stockholm University, Faculty of Science, Department of Mathematics and Science Education.
    Late-arrived immigrants in school and performance in arithmetic for negative numbers2013In: Proceedings of the 37th Conference of the International Group for the Psychology of Mathematics Education / [ed] Anke M. Lindmeier, Aiso Heinze, International Group for the Psychology of Mathematics Education , 2013, Vol. 5, 252-252 p.Conference paper (Refereed)
    Abstract [en]

    This paper reports from a study on immigrant and native students tested in negative number arithmetic as one of several topics in school mathematics. In general immigrant students perform lower the later they have immigrated (Böhlmark, 2008). Students often find working with negative numbers difficult and Vlassis (2004) identified two kinds of conceptual changes needed for productive use of the minus and subtraction sign. First, the arithmetic rules are different for addition and subtraction. For example, subtraction is not commutative. Second, the minus sign has a flexible use exemplified by the expression (-23) + 9 = 9 – 23 = -(23 – 9). The expression uses the minus sign as a signed integer (non-operational), a subtraction (operational) and a reflection (operational) and a flexible change between these.

    In this study 356 school year 9 students in six Swedish schools, with an over average percentage of immigrants, took a test. Several test problems were formulated so that they were likely to not cause too much of language obstacles for second language learners. In this report the test problem “Calculate 12 – 23 + 9” is in focus. This problem was characterized in Duval’s (2006) semiotic registers as mainly “computations” and scarcely dependent on natural language. One result is that about half of the solutions contained sign errors. There were few arithmetic errors and few other unclassified errors. A second result is that the students who immigrated during school years 1 – 7 clearly underperformed compared to the other students while those who immigrated during school years 8 – 9 performed slightly better than the native students. In this on-going research project one conclusion is that there seems to be a need to see early and late immigrants as having different challenges in being second language learners. The former have difficulties in following some advanced topics in mathematics teaching and the latter have difficulties in understanding some test questions. A second conclusion is that there is a need in research to look at specific topics in mathematics, especially advanced compulsory school mathematics such as negative numbers and algebra, for these student categories.

  • Petersson, Jöran
    Stockholm University, Faculty of Science, Department of Mathematics and Science Education.
    Late-arrived immigrants in school and performance in algebra2013In: Proceedings of the 37th Conference of the International Group for the Psychology of Mathematics Education / [ed] Anke M. Lindmeier, Aiso Heinze, International Group for the Psychology of Mathematics Education , 2013, Vol. 5, 143-143 p.Conference paper (Refereed)
    Abstract [en]

    This paper reports from a study on immigrant and native students tested in algebra asone of several topics in school mathematics. In general immigrant students performlower the later they have immigrated (Böhlmark, 2008). Students often find workingwith algebra difficult and Kieran (1992) noted that new-beginners in algebra oftenread algebraic expressions from left to right and might ignore the brackets.In this study 358 school year 9 students in six Swedish schools, with an over averagepercentage of immigrants, took a test. Several test problems were formulated so thatthey were likely to not cause too much of language obstacles for second languagelearners. In this report the test problem “a = 2, b = 4. What is a(b+2)+b?” is in focus.This problem was characterized in Duval’s (2006) semiotic registers as mainly“computations” and scarcely dependent on natural language.An important result is that the students who immigrated during school years 8 – 9performed better than the native students and much better than students whoimmigrated during school years 1 – 7. Most wrong solutions among all studentcategories were due to misuse of the distributive law in line with Kieran (1992).There were few arithmetic errors.In this on-going research project one conclusion is that there seems to be a need tosee early and late immigrants as having different challenges in being second languagelearners. The former have difficulties in following some advanced topics inmathematics teaching and the latter have difficulties in understanding some testquestions. A second conclusion is that there is a need in research to look at specifictopics in mathematics, especially advanced compulsory school mathematics such asnegative numbers and algebra, for these student categories.

  • Petersson, Jöran
    Stockholm University, Faculty of Science, Department of Mathematics and Science Education.
    Recent and early immigrants’ achievements in mathematics2015In: Nordic Conference on Subject Education: Book of Abstracts, University of Helsinki, 2015, 111-111 p.Conference paper (Refereed)
    Abstract [en]

    Achievement in mathematics, science and language is often used as national indicators and a personal bridge for future opportunities to work and education. One Swedish school law defines a ‘recent immigrant’ as the first four semesters during school years 6-9 of immigrated students. In an ongoing research project, the distribution of students’ different solving strategies in a multilingual classroom is studied through a test. Preliminary results are that students who immigrated in school years 8-9 in many cases show higher mathematical quality than those who immigrated during school years 1-7. This can be interpreted as a partial exclusion from taking a productive part in the mathematics classroom due to being second language learner. This raises questions of extending the definition of recent immigrants to all newly immigrated students disregarding their age and thus allow all newcomers extra support needed to include them in the mathematics classroom.

  • Petersson, Jöran
    Stockholm University, Faculty of Science, Department of Mathematics and Science Education.
    Students determining the median for different data sets: A spectrum of responses2016Conference paper (Refereed)
    Abstract [en]

    The present study reports on 359 students’ responses to two test items on the median. Among the responses were other measures of location such as the arithmetic mean and the midrange. Moreover, among those who used a median strategy there was a spectrum of sources of confusion in the data set. In one test item the data were given in a table of signed integers and some students ignored the negative signs in the data. In the other test item the data were given in a bivariate diagram. Instead of correctly using the horizontal coordinate of the data, several students used the axis grading or the vertical coordinates as data. A conclusion is that the representation format of the data had a large effect on the achievement on the two test items.

  • Dolo, Gilbert
    et al.
    University of Cape Town, South Africa.
    Haglund, Jesper
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Physics Didactics.
    Schönborn, Konrad J.
    Linköping University.
    Stimulating and supporting inquiry-based science learning with infrared cameras in South Africa2017In: / [ed] Mike K. Mholo & Carolyn Stevenson-Milln, Bloemfontein, South Africa: AFRICAN SUN MeDIA, 2017, 243-245 p.Conference paper (Other academic)
  • Norén, Eva
    et al.
    Stockholm University, Faculty of Science, Department of Mathematics and Science Education.
    Petersson, Jöran
    Stockholm University, Faculty of Science, Department of Mathematics and Science Education.
    Algebra tasks in a word problem and non-word problem context – a multilingual project2014In: Development of mathematics teaching: design, scale, effects: Proceedings of MADIF 9: the ninth Swedish mathematics education research seminar, Umeå, February 4-5, 2014 / [ed] Ola Helenius, Arne Engström, Tamsin Meaney, Per Nilsson, Eva Norén, Judy Sayers, Magnus Österholm, Göteborg: Svensk förening för MatematikDidaktisk Forskning - SMDF, 2014Conference paper (Refereed)
    Abstract [en]

    Many students see algebra as a difficult topic. For second language speakers there might also be difficulties comprehending an algebra task linguistically correct. The authors suggest studying how knowledge in algebra and linguistic registers in mathematics interplay for both newly early arrived immigrants compared to first language speakers. We suggest the tools for such a study to be measuring achievement and solution strategy while varying the text intensity and mathematics register in algebra problems for students with different length of experience of Swedish language in school year 9. We want to discuss design of test instrument and methods for background data collection.

  • Public defence: 2017-04-07 09:00 Sal F3, Stockholm
    Khurshid, Mansoor
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Lightweight Structures.
    Static and fatigue analyses of welded steel structures: some aspects towards lightweight design2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The objectives of this thesis comprise of overcoming the challenges in designing lightweight welded structures such as material selection, choice of fatigue design methods, and increased performance by using improvement techniques. Material selection of welded joints is dependent on the filler and base material strengths. Partially and fully penetrated cruciform and butt welded joints were designed in under-matching, matching, and over-matching filler materials. Base material steel grades were S600MC, S700MC, and S960. Current design rules are developed for welds in steel up to yield strength of 700MPa. Therefore, design rules in Eurocode3, AWS d1.1, and BSK 07 were verified and recommendations for developing design rules for designing welded joints in S960 were concluded. Numerical methodology for estimating static strength of welded joints by simulating heat affected zone was also developed.

    Another objective of the thesis work was to overcome the challenges in selection of fatigue design methods. The available design curves in standards are developed for uniaxial stress states, however, in real life the welds in mechanical structures are subjected to complex multiaxial stress states. Furthermore; weld toe failures are frequently investigated, weld root failures are seldom investigated. Therefore, in this work the multiaxial fatigue strength of welded joints failing at the weld root was assessed using experiments and various nominal and local stress based approaches. Butt welded joints with different weld seam inclinations with respect to applied uniaxial loading were designed to assess the root fatigue strength in higher multiaxial stress ratio regime. The fatigue strength of multi-pass tube-to-plate welded joints subjected to internal pressure only and combined internal pressure and torsion in and 90° out of phase loading was also investigated. Test data generated in this thesis was evaluated together with the test data collected from literature.

    Last objective of the thesis included investigation of the increased performance in fatigue strength by post weld treatment methods such as HFMI. The behavior of residual stresses induced due to HFMI treatment during fatigue loading is studied. Numerical residual stress estimations and residual stress relaxation models are developed and the effect of various HFMI treatment process parameters and steel grade on the induced residual stress state is investigated. Specimens studied were non load carrying longitudinal attachments and simple plates. Residual stresses in both test specimens were measured using X-ray diffraction technique.

  • Brännström, Lotta
    et al.
    Mid Sweden University, Faculty of Human Sciences, Department of Social Sciences.
    Nourallah, MustafaMid Sweden University, Faculty of Human Sciences, Department of Business, Economics and Law.
    Disrupted Stories2017Collection (editor) (Other academic)
  • Public defence: 2017-02-24 13:15 Utvandrarnas hus, Växjö
    Holmér, Gunnel
    Linnaeus University, Faculty of Arts and Humanities, Department of Cultural Sciences.
    Flaskor på löpande band: Arbete och arbetskraftsrekrytering vid Surte glasbruk 1943-19782017Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This dissertation considers how the transition from craft manufacture to mechanized glass production affected the organization of work and the consequences for the recruitment of labour. Based on gender and ethnicity, the dissertation studies the composition of the workforce, the significance of qualifications, and differences in career paths and length of stay have been investigated at Surte glassworks 1943–1978. Charles Tilly’s theory of durable inequality is applied to analyse whether primarily gender and ethnicity had any effect on the assignment of tasks and on discrimination. In conclusion, the results from Surte are compared with conditions at Kosta glassworks. Whereas Surte’s specialty was machine-made bottles, Kosta was geared to craft production of utility glass and art glass.

    After mechanization at Surte, machine-tenders were counted among the most qualified category, instead of the glass-blowers who had previously been in demand. Manufacture at a pace regulated by machines led to more routine chores such as inspection and packaging. At Kosta, with its focus on craft, glass-blowers still had the highest positions and had learned glass-blowing in the traditional way through practical exercise. At neither Surte nor Kosta did women have any opportunity to receive comparable training.

    After the Second World War there was a growing need for labour at both Surte and Kosta, and to keep production going the main alternative was foreign labour. The peak was reached in the 1960s, and of roughly 660 collectively employed workers at Surte in November 1964, almost 40% were immigrants, chiefly from Finland. Kosta at the same time, with just under 330 employees, had slightly under 10% foreign workers, mainly from Greece. Kosta attracted a number of skilled glass-workers from abroad, but the majority of immigrants there, and all those at Surte, lacked experience of glass manufacture

    At neither Surte nor Kosta, with their different production methods, is there any evidence of durable inequality based on ethnicity. The assignment of tasks was guided rather by the functions in demand at the companies and by the applicants’ qualifications. Internal training and career opportunities were open to all male workers, regardless of which country they came from. On the other hand, the gender division of labour at both glassworks created durable inequality for all women regardless of nationality. 

  • Philipson, Joakim
    Stockholm University, University Library.
    What's in a name?: Sense and Reference in biodiversity information2016In: TDWG 2016 Annual Conference, Santa Clara de San Carlos, COSTA RICA 5-9 December 2016, Missouri Botanical Garden , 2016Conference paper (Other academic)
    Abstract [en]

    "That which we call a rose by any other name would smell as sweet." Shakespeare has Juliet tell her Romeo that a name is just a convention without meaning, what counts is the reference, the 'thing itself', to which the property of smelling sweet pertains alone. Frege in his classical paper “Über Sinn und Bedeutung” was not so sure, he assumed names can be inherently meaningful, even without a known reference. And Wittgenstein later in Philosophical Investigations (PI) seems to deny the sheer arbitrariness of names and reject looking for meaning out of context, by pointing to our inability to just utter some random sounds and by that really implying e.g. the door. The word cannot simply be separated from its meaning, in the same way as the money from the cow that could be bought for them (PI 120). Scientific names of biota, in particular, are often descriptive of properties pertaining to the organism or species itself. On the other hand,  in semantic web technology and Linked Open Data (LOD) there is an overall effort to replace names by  their references, in the form of web links or Uniform Resource Identifiers (URIs). “Things, not strings” is the motto. But, even in view of the many "challenges with using names to link digital biodiversity information" that were extensively described in a recent paper, would it at all be possible or even desirable to replace scientific names of biota with URIs? Or would it be sufficient to just identify equivalence relationships between different variants of names of the same biota, having the same reference, and then just link them to the same “thing”, by means of a property sameAs(URI)?  The Global Names Architecture (GNA) has a resolver of scientific names that is already doing that kind of work, linking names of biota such as Pinus thunbergii to global identifiers and URIs from other data sources, such as Encyclopedia of Life (EOL) and uBio Namebank. But there may be other challenges with going from a “natural language”, even from a not entirely coherent system of scientific names, to a semantic web ontology, a solution to some of which have been proposed recently by means of so called 'lexical bridges'.

  • Lindström, Lisbeth
    et al.
    Luleå University of Technology, Department of Arts, Communication and Education, Education, Language, and Teaching.
    Öqvist, Anna
    Luleå University of Technology, Department of Arts, Communication and Education, Education, Language, and Teaching.
    Assessing the Meeting Places of Youth for Citizenship and Socialization2013In: International Journal of Social Sciences and Education, ISSN 2227-393X, E-ISSN 2223-4934, Vol. 3, no 2, 446-462 p.Article in journal (Refereed)
    Abstract [en]

    The purpose of this article is to describe, explore and discuss whether meeting places for youth such as youth clubs support their citizenship in terms of gender equality, influence and participation. The following questions were of interest; what is the overall aim of the local councils regarding these clubs and meeting places? What kind of activities do they offer and what kind of citizenship do they support? The result shows that these places are more attractive to boys than to girls. Furthermore, these meeting places can, if developed, be places for the development of youth citizenship from the perspective of integration, gender equality and participation.

  • Wollin, Lars
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    TRIX: Translation index – ett sätt att studera översättningManuscript (preprint) (Other academic)
    Abstract [sv]

    TRIX (translation index) är ett instrument utformat som ett indextal, tänkt för kvantitativt anlagd språkanalys i beskrivning av och forskning kring skriven översättning. Det är utarbetat av författaren till föreliggande presentation.

    TRIX är avsett att summariskt karakterisera övergripande mönster i en översättares språkutformning. Talet mäter graden av s.k. formell ekvivalens mellan en text tillkommen genom översättning och dess förlaga, alltså om och i vilken mån texten är vad som till vardags brukar omtalas som ”fri” eller ”bunden”. Ju högre TRIX-värde, desto mer ”bunden” är en given översättning.

    TRIX-analysen opererar med två variabler, förankrade i var sin grundläggande dimension av språkstrukturen: den lexikala och den grammatiska. För vardera variabeln noteras ett delvärde på en skala mellan 0 och 100. Dessas medelvärde är TRIX.

    Vid sidan av själva översättningen – som alltså är dess egentliga domän – medger TRIX-analysen samtidigt studium av stilistiska dimensioner i språkstrukturen som kan vara intressanta i relation till översättningen. Hittills prövade är (syntaktisk) komplexitet och ordbalans, beräknade i variabler som meningslängd och nominalkvot.

  • Rapp, Stephan
    et al.
    Jönköping University, School of Education and Communication, HLK, School Based Research, School Based Research and Professional Development.
    Skoglund, Peter
    Linnéuniversitetet .
    Skolans juridifiering: Ett skolchefsperspektiv2017Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    Allt fler stämmor höjs mot det som man upplever som en juridifiering av skolväsendet och kritik riktas mot att skolans personal inte har tid med pedagogiska frågor då de måste hålla koll på juridiken. Samtidigt finns andra röster som säger att i en verksamhet med myndighetsutövande inslag måste arbetet styras av en juridisk reglering. I den här rapporten gör vi inledningsvis en historisk tillbakablick i syfte att bättre försöka förstå bakgrunden till skolans förändrade juridiska styrning. Härigenom kan vi också kasta ljus över varför juridiken alltmer kommit att fokuseras i skolan under senare tid. Vi kommer vidare att på ett konkret plan redovisa delar av den juridiska regleringen av skolans verksamhet och diskutera det som idag allt mer kommit att benämnas som en juridifiering av skolväsendet.

    Vad handlar då denna juridifiering om? Det som ofta diskuteras är en starkare central styrning men detta räcker inte för att förstå de pågående förändringarna. Ett ökat fokus på den enskilde elevens rättigheter är ett kännetecken för den pågående juridifieringen. Det handlar om rättigheter till korrekt behandling, stöd och möjligheter att överklaga beslut. Ett förtydligande av individens rättigheter bör ses som en positiv utveckling av verksamheten även om det innebärett mer omfattande regelverk. En annan förändring, och kanske bidragande orsak till att regelverket förstärks, är möjligheten för privata aktörer att inordna sig i ett förvaltningsrättsligt regelsystem somtidigare i stort sett varit förbehållet den offentliga sektorn. Detta ökar samtidigt kraven på rättssäkerhetsregler för att skapa ett gemensamt ramverk inom vilket skolverksamheten ska ske.

    Mot bakgrund av den ökade juridifieringen blir det intressant att diskutera skolchefens roll och möjligheter att påverka. Skolchefsuppdraget är till skillnad mot rektorsuppdraget inte reglerat i lag men samtidigt har skolchefen en central position som huvudmannens företrädare. Och det är i huvudmannens intresse att värna om elevernas rättigheter. I detta arbete utgör juridifieringen ett viktigt skyddsnät men de huvudsakliga frågorna bör handla om att stärka pedagogik, lärande och ett gott ledarskap i skolan.

  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Geografi är ingen från naturgeografin och kulturgeografin skild särart2008In: Geografiska Notiser, ISSN 0016-724X, Vol. 66, no 1, 8-10 p.Article in journal (Other (popular science, discussion, etc.))
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Geographical approaches to field systems in Swedish prehistory and early history1989In: Approaches to Swedish prehistory: A spectrum of problems and perspectives in contemporary research / [ed] Thomas B. Larsson & Hans Lundmark, Oxford: British Archaeological Reports , 1989, 353-366 p.Chapter in book (Other academic)
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Archaeology and geography in Sweden: Common research themes and contrasting views in the last twenty years1985In: In honorem Evert Baudou / [ed] Margareta Backe, Umeå: Umeå Universitet , 1985, 155-162 p.Chapter in book (Other academic)
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Om skillnader och likheter mellan regioner: Några kommentarer till 3 figurer1988In: Folkevandringstiden i Norden: En krisetid mellem ældre og yngre jernalder / [ed] Ulf Näsman & Jørgen Lund, Århus: Aarhus Universitetsforlag, 1988, 273-287 p.Chapter in book (Other academic)
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Västsveriges kulturlandskap från geografisk synpunkt1986In: Bebyggelsehistorisk tidskrift, ISSN 0349-2834, Vol. 10, 7-18 p.Article in journal (Other academic)
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Kulturlandskapsförändringar under första årtusendet: Tankar kring förklaringar och ansts till en regional översikt1984In: Teoretiska studier om kulturlandskapets utveckling: Rapport från ett symposium 10-11 november 1983, Stockholm: Samrådskomm. för arkeologi och naturvetenskap , 1984, 96-116 p.Conference paper (Other academic)
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Bebyggelseform och markrättigheter under järnåldern1986In: Ymer, 18-26 p.Article in journal (Other academic)
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Landskap eller objekt: Kring kulturminesvårdens problem att hantera landskapets historia1997In: Landskapet som historie / [ed] Jan Brendalsmo & Mats Widgren, Oslo: Norsk institutt for kulturminneforskning , 1997, 5-16 p.Chapter in book (Other academic)
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Landscapes as Museums - Landscapes as Archives1993In: Bebyggelsehistorisk tidskrift, ISSN 0349-2834, Vol. 26, 65-70 p.Article in journal (Refereed)
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Strip fields in an Iron-Age context: A case study from Västergötland, Sweden1990In: Landscape History, ISSN 0143-3768, E-ISSN 2160-2506, Vol. 12, no 1, 5-24 p.Article in journal (Refereed)
    Abstract [en]

    As part of a project on the origin of subdivided fields in Western Sweden some surprisingly old planned fields have been investigated in the southern parts of the province of Västergötland. A type of large fossilised field consisting of long strips bounded by banks of stone and earth was found while searching for partially deserted medieval sub-divided fields. The breadth of the strips varies from approximately 7 to 40 metres. To judge from the remaining evidence, the fields often covered areas of over 50 hectares. The spatial relationship between the fields and other ancient monuments points to a date in the last centuries B.C. This dating has also been confirmed by radio-carbon datings from field boundaries, indicating a use in the period 500 B.C. to A.D. 200. The layout of the strips follows geometrical principles rather than the terrain and gives the impression of deliberate planning according to some yet unknown principle. Some of the localities consist of broad strips which have functioned as frameworks within which subdivision into property and/or working plots has later been developed. This land division seems mainly to have its origin in the need to regulate the rights to land. Strips are often too broad to have been working plots and they lack any sign of traction implements. All evidence so far points to collectively organised, subdivided field systems which have many traits in common with the medieval open fields. A metrological analysis shows that the fields were planned, measured and subsequently subdivided. The finds raise principal questions concerning the origin of subdivided fields and of individual and collective rights in the landscape. Two directions for discussion emerge. One concerns the antecedent forms in the landscape and the circumstances under which these land divisions were carried out, the other concerns the principal relations between these field systems and later subdivided fields.

  • Tollin, Clas
    et al.
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Historical Map Overlays: A Method for the Analysis and Planning of the Agrarian Landscape1992In: Tijdschrift van de Belgische Vereniging voor Aardrijkskundige Studies, Vol. 61, 109-115 p.Article in journal (Other academic)
  • Englund, Claire
    et al.
    Umeå University, Umeå University Library, Centre for teaching and learning (UPL).
    Gustafsson, Maria
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
    Gallego, Gisselle
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology. School of Medicine, The University of Notre Dame, Australia, New South Wales 2010, Australia.
    Pharmacy Students' Attitudes and Perceptions of "Virtual Worlds" as an Instructional Tool for Clinical Pharmacy Teaching2017In: Pharmacy, ISSN 2226-4787, Vol. 5, no 1, 5Article in journal (Refereed)
    Abstract [en]

    The objectives of this study were to explore pharmacy students’ perceptions and experiences of three-dimensional virtual worlds (3DVWs) as an instructional tool for clinical pharmacy teaching. Semi-structured interviews were carried out with Master of Science in Pharmacy students who had participated in communicative exercises in a 3DVW. Interviews were digitally recorded, transcribed and analyzed using thematic analysis. More than half of the students were positive to using 3DVWs for educational purposes and see the advantages of having a setting where communication can be practiced in an authentic but ‘safe’ environment available online. However, many students also reported technical difficulties in using the 3DVW which impacted negatively on the learning experience. Perceived ease of use and usefulness of 3DVWs appears to play an important role for students. The students’ level of engagement relates to not only their computer skills, but also to the value they place on 3DVWs as an instructional tool.

  • Osman, Yasin
    et al.
    University of Bolton.
    Abdellatif, Mawada
    Liverpool JM University.
    Al-Ansari, Nadhir
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Mining and Geotechnical Engineering.
    Knutsson, Sven
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Mining and Geotechnical Engineering.
    Jawad, Sadeq
    Iraqi Government, Prime Minister Advisory Commission.
    Climate Change and Future Precipitation in Arid Environment of Middle East: Case study of Iraq2017In: Journal of Environmental Hydrology, ISSN 1058-3912, E-ISSN 1996-7918, Vol. 25, 1-18 p., 3Article in journal (Refereed)
    Abstract [en]

    In this paper impact of climate change on precipitation in the arid environment of Iraq is examined.  LARS-WG weather generator was applied to 5 representative regions to model current and future precipitation under climate change. Seven Global Climate Models (GCMs) have been employed to account for any uncertainty on future projection for three selected periods, 2011-2030, 2046-2065 and 2080-2099. Performance of LARS-WG in each site was first evaluated using the Kolmogorov-Smirnov statistical test for fitting wet/dry days in each site, as well as comparison of the mean and standard deviation between the observed and simulated precipitation. The developed LARS-WG models were found to perform well and skilful in simulating precipitation in the arid regions of Iraq as evidenced by the tests carried and the comparison made. The precipitation models were then used to obtain future projections for precipitation using the IPCC scenario SRES A2. Future precipitation results show that most of the Iraq regions are projected to suffer a reduction in annual mean precipitation, especially by the end of the 21st century, while on a seasonal basis most of the regions are anticipated to be wetter in autumn and winter.

     

  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Fossila landskap: En forskningsöversikt över odlingslandskapets utveckling från yngre bronsålder till tidig medeltid1997Book (Other academic)
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Kulturgeografernas bönder och arkeologernas guld: Finns det någon väg till en syntes?1998In: Centrala platser – centrala frågor: Samhällsstrukturen under järnåldern / [ed] Lars Larsson & Birgitta Hårdh, Stockholm: Almqvist & Wiksell, 1998, 281-296 p.Chapter in book (Other academic)
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Geografisk forskning och landskapet under norsk medeltid1998In: Storöya: Hamarbiskopens ladegård i middelalderen? / [ed] A. Jan Brendalsmo, Oslo: Norsk institutt for kulturminneforskning , 1998, 48-49 p.Conference paper (Other academic)
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Reflections on landscape and settlement transformations1999In: Settlement and Landscape: Proceedings of a conference in Århus, Denmark, May 4-7 1998. / [ed] Charlotte Fabech & Jytte Ringtved, Århus: Jutland Archaeological Society , 1999, 31-33 p.Chapter in book (Other academic)
  • Connelid, Pär
    et al.
    Mascher, Catharina
    Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Länghem: By, huvudgård, kyrka och slitstark trikå2001In: Från stad till land: En medeltidsarkeologisk resa tillägnad Hans Andersson. / [ed] Andrén, Anders ; Ersgård, Lars: Wienberg, Jes., Stockholm: Almqvist & Wiksell, 2001, 23-34 p.Chapter in book (Other academic)
  • Widgren, Mats
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Can landscapes be read?2004In: European rural landscapes: Persistence and change in a globalising environment / [ed] H. Palang, H. Sooväli, M. Antrop, Boston: Kluwer Academic Publishers, 2004, 455-465 p.Chapter in book (Refereed)
  • Molin, Carl Johan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
    Westerberg, Elisabet
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
    Rostedt Punga, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
    Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 39716Article in journal (Refereed)
    Abstract [en]

    This study describes specific patterns of elevated inflammatory proteins in clinical subtypes of myasthenia gravis (MG) patients. MG is a chronic, autoimmune neuromuscular disease with antibodies most commonly targeting the acetylcholine receptors (AChRab), which causes fluctuating skeletal muscle fatigue. MG pathophysiology includes a strong component of inflammation, and a large proportion of patients with early onset MG additionally present thymus hyperplasia. Due to the fluctuating nature and heterogeneity of the disease, there is a great need for objective biomarkers as well as novel potential inflammatory targets. We examined the sera of 45 MG patients (40 AChRab seropositive and 5 AChRab seronegative), investigating 92 proteins associated with inflammation. Eleven of the analysed proteins were significantly elevated compared to healthy controls, out of which the three most significant were: matrix metalloproteinase 10 (MMP-10; p = 0.0004), transforming growth factor alpha (TGF-α; p = 0.0017) and extracellular newly identified receptor for advanced glycation end-products binding protein (EN-RAGE) (also known as protein S100-A12; p = 0.0054). Further, levels of MMP-10, C-X-C motif ligand 1 (CXCL1) and brain derived neurotrophic factor (BDNF) differed between early and late onset MG. These novel targets provide valuable additional insight into the systemic inflammatory response in MG.

  • Muthumanickam, Prithiviraj
    et al.
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering.
    Vrotsou, Katerina
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering.
    Cooper, Matthew
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering.
    Johansson, Jimmy
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering.
    Shape Grammar Extraction for Efficient Query-by-Sketch Pattern Matching in Long Time Series2016Conference paper (Refereed)
    Abstract [en]

    Long time-series, involving thousands or even millions of time steps, are common in many application domains but remain very difficult to explore interactively. Often the analytical task in such data is to identify specific patterns, but this is a very complex and computationally difficult problem and so focusing the search in order to only identify interesting patterns is a common solution. We propose an efficient method for exploring user-sketched patterns, incorporating the domain expert’s knowledge, in time series data through a shape grammar based approach. The shape grammar is extracted from the time series by considering the data as a combination of basic elementary shapes positioned across different am- plitudes. We represent these basic shapes using a ratio value, perform binning on ratio values and apply a symbolic approximation. Our proposed method for pattern matching is amplitude-, scale- and translation-invariant and, since the pattern search and pattern con- straint relaxation happen at the symbolic level, is very efficient permitting its use in a real-time/online system. We demonstrate the effectiveness of our method in a case study on stock market data although it is applicable to any numeric time series data.

  • Landreh, Michael
    et al.
    Marklund, Erik G
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Biochemistry.
    Uzdavinys, Povilas
    Degiacomi, Matteo T.
    Coincon, Mathieu
    Gault, Joseph
    Gupta, Kallol
    Liko, Idlir
    Benesch, Justin L. P.
    Drew, David
    Robinson, Carol V.
    Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters2017In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, 13993Article in journal (Refereed)
    Abstract [en]

    Na+/H+ antiporters are found in all kingdoms of life and exhibit catalysis rates that are among the fastest of all known secondary-active transporters. Here we combine ion mobility mass spectrometry and molecular dynamics simulations to study the conformational stability and lipid-binding properties of the Na+/H+ exchanger NapA from Thermus thermophilus and compare this to the prototypical antiporter NhaA from Escherichia coli and the human homologue NHA2. We find that NapA and NHA2, but not NhaA, form stable dimers and do not selectively retain membrane lipids. By comparing wild-type NapA with engineered variants, we show that the unfolding of the protein in the gas phase involves the disruption of inter-domain contacts. Lipids around the domain interface protect the native fold in the gas phase by mediating contacts between the mobile protein segments. We speculate that elevator-type antiporters such as NapA, and likely NHA2, use a subset of annular lipids as structural support to facilitate large-scale conformational changes within the membrane.

  • Rasmussen, Stine
    et al.
    Madsen, Per Kongshøj
    Saloniemi, Antti
    Ólafsdóttir, Katrín
    Dølvik, Jon Erik
    Jesnes, Kristin
    Rolandsson, Bertil
    Petersson, Jesper
    Berglund, Tomas
    Nordic labour markets and the sharing economy: National Background Reports2017Report (Refereed)
    Abstract [en]

    This collection of national background reports are produced as part of a pilot project on Nordic Labour Markets and the Sharing Economy funded by the Nordic Council of Ministers and organized by Fafo, Oslo. The aim of the pilot project was to facilitate Nordic information exchange and provide a better knowledge base for developing future Nordic studies in this area. As part of the project, Fafo invited a group of researchers from all the Nordic countries to prepare short national background papers and take part in a two day workshop in Oslo, 26-27 September 2016. The national background papers were written within very restricted budget frames, and should be read in combination with the overall report from the pilot project, please find the main report on this page. The Nordic research group has consisted of Antti Saloniemi (University of Tampere), Per Kongshøj-Madsen and Stine Rasmussen (CARMA, Aalborg University), Anna Illsøe (FAOS, Copehagen University), Bertil Rolandsson, Jesper Peterson and Tomas Berglund (University of Gothenburg), Katrín Ólafsdóttir (Reykjavik University School of Business), and Jon Erik Dølvik and Kristin Jesnes (Fafo).