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  • Al-Jebari, Yahia
    et al.
    Lund Univ, Mol Reprod Med, Dept Translat Med, Malmo, Sweden.
    Glimelius, Ingrid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. Karolinska Inst, Div Clin Epidemiol, Dept Med, Stockholm, Sweden.
    Nord, Carina Berglund
    Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.
    Cohn-Cedermark, Gabriella
    Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.
    Stahl, Olof
    Skane Univ Hosp, Dept Oncol, Lund, Sweden.
    Tandstad, Torgrim
    Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Fac Med & Hlth Sci, Trondheim, Norway;St Olavs Univ Hosp, Canc Clin, Trondheim, Norway.
    Jensen, Allan
    Danish Canc Soc Res Ctr, Virus Lifestyle & Genes, Copenhagen, Denmark.
    Haugnes, Hege Sagstuen
    Univ Hosp North Norway, Dept Oncol, Tromso, Norway;UiT Arctic Univ Norway, Inst Clin Med, Tromso, Norway.
    Daugaard, Gedske
    Rigshosp, Dept Oncol, Copenhagen Univ Hosp, Copenhagen, Denmark.
    Rylander, Lars
    Lund Univ, Div Occupat & Environm Med, Lund, Sweden.
    Giwercman, Aleksander
    Lund Univ, Mol Reprod Med, Dept Translat Med, Malmo, Sweden.
    Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study2019In: PLoS Medicine, ISSN 1549-1277, E-ISSN 1549-1676, Vol. 16, no 6, article id e1002816Article in journal (Refereed)
    Abstract [en]

    Background Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk was recently reported in children born before paternal cancer. This study aims to investigate whether anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional CM risk. Methods and findings In this nationwide register study, all singletons born in Sweden 1994-2014 (n = 2,027,997) were included. Paternal TGCC diagnoses (n = 2,380), anti-neoplastic treatment, and offspring CMs were gathered from the Swedish Norwegian Testicular Cancer Group (SWENOTECA) and the Swedish Medical Birth Register. Children were grouped based on +/- paternal TGCC; treatment regimen: surveillance (n = 1,340), chemotherapy (n = 2,533), or radiotherapy (n = 360); and according to time of conception: pre- (n = 2,770) or post-treatment (n = 1,437). Odds ratios (ORs) for CMs were calculated using logistic regression with adjustment for parental ages, maternal body mass index (BMI), and maternal smoking. Children conceived before a specific treatment acted as reference for children conceived after the same treatment. Among children fathered by men with TGCC (n = 4,207), 184 had a CM. The risk of malformations was higher among children of fathers with TGCC compared with children fathered by men without TGCC (OR 1.28, 95% confidence interval [CI] 1.19-1.38, p = 0.001, 4.4% versus 3.5%). However, no additional risk increase was associated with oncological treatment when comparing post-treatment-to pretreatment-conceived children (chemotherapy, OR = 0.82, 95% CI 0.54-1.25, p = 0.37, 4.1% versus 4.6%; radiotherapy, OR = 1.01, 95% CI 0.25-4.12, p = 0.98, 3.2% versus 3.0%). Study limitations include lack of data on use of cryopreserved or donor sperm and on seminoma patients for the period 1995-2000-both tending to decrease the difference between the groups with TGCC and without TGCC. Furthermore, the power of analyses on chemotherapy intensity and radiotherapy was limited. Conclusions No additional increased risk of CMs was observed in children of men with TGCC treated with radio- or chemotherapy. However, paternal TGCC per se was associated with modestly increased risk for offspring malformations. Clinically, this information can reassure concerned patients.

  • Shanahan, Danielle F.
    et al.
    Zealandia Ctr People & Nat, Wellington 6012, New Zealand.
    Astell-Burt, Thomas
    Univ Wollongong, Sch Hlth & Soc, Populat Wellbeing & Environm Res Lab PowerLab, Wollongong, NSW 2522, Australia.
    Barber, Elizabeth A.
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld 4006, Australia.
    Brymer, Eric
    Australian Coll Appl Psychol, Discipline Psychol, Brisbane, Qld 4000, Australia.
    C., Daniel T.
    Univ Exeter, Environm & Sustainabil Inst, Penryn TR10 9EZ, Cornwall, England.
    Dean, Julie
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld 4006, Australia.
    Depledge, Michael
    Univ Exeter, Sch Med, European Ctr Environm & Human Hlth, Exeter EX1 2LU, Devon, England.
    Fuller, Richard A.
    Univ Queensland, Sch Biol Sci, Brisbane, Qld 4072, Australia.
    Hartig, Terry
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Institute for Housing and Urban Research.
    Irvine, Katherine N.
    James Hutton Inst, Social Econ & Geog Sci, Aberdeen AB15 8QH, Scotland.
    Jones, Andy
    Univ East Anglia, Norwich Med Sch, Norwich NR15 1LT, Norfolk, England.
    Kikillus, Heidy
    Victoria Univ Wellington, Ctr Biodivers & Restorat Ecol, Wellington 6012, New Zealand.
    Lovell, Rebecca
    Univ Exeter, Sch Med, European Ctr Environm & Human Hlth, Truro TR1 3HD, England.
    Mitchell, Richard
    Univ Glasgow, Ctr Res Environm Soc & Hlth, Glasgow G12 8QQ, Lanark, Scotland.
    Niemelae, Jari
    Univ Helsinki, Dept Environm Sci, Helsinki 00014, Finland.
    Nieuwenhuijsen, Mark
    Barcelona Inst Global Hlth, ISGlobal, Barcelona Biomed Res Pk PRBB, Barcelona 08003, Spain.
    Pretty, Jules
    Univ Essex, Dept Biol Sci, Colchester CO4 3SQ, Essex, England.
    Townsend, Mardie
    Deakin Univ, Sch Hlth & Social Dev, Geelong, Vic 3217, Australia.
    van Heezik, Yolanda
    Univ Otago, Dept Zool, Dunedin 9016, New Zealand.
    Warber, Sara
    Univ Michigan, Integrat Med, Ann Arbor, MI 48710 USA.
    Gaston, Kevin J.
    Univ Exeter, Environm & Sustainabil Inst, Penryn TR10 9EZ, Cornwall, England.
    Nature-Based Interventions for Improving Health and Wellbeing: The Purpose, the People and the Outcomes2019In: SPORTS, ISSN 2075-4663, Vol. 7, no 6, article id 141Article in journal (Refereed)
    Abstract [en]

    Engagement with nature is an important part of many people's lives, and the health and wellbeing benefits of nature-based activities are becoming increasingly recognised across disciplines from city planning to medicine. Despite this, urbanisation, challenges of modern life and environmental degradation are leading to a reduction in both the quantity and the quality of nature experiences. Nature-based health interventions (NBIs) can facilitate behavioural change through a somewhat structured promotion of nature-based experiences and, in doing so, promote improved physical, mental and social health and wellbeing. We conducted a Delphi expert elicitation process with 19 experts from seven countries (all named authors on this paper) to identify the different forms that such interventions take, the potential health outcomes and the target beneficiaries. In total, 27 NBIs were identified, aiming to prevent illness, promote wellbeing and treat specific physical, mental or social health and wellbeing conditions. These interventions were broadly categorized into those that change the environment in which people live, work, learn, recreate or heal (for example, the provision of gardens in hospitals or parks in cities) and those that change behaviour (for example, engaging people through organized programmes or other activities). We also noted the range of factors (such as socioeconomic variation) that will inevitably influence the extent to which these interventions succeed. We conclude with a call for research to identify the drivers influencing the effectiveness of NBIs in enhancing health and wellbeing.

  • del Aguila Pla, Pol
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Information Science and Engineering.
    Pellaco, Lissy
    KTH, School of Electrical Engineering and Computer Science (EECS), Information Science and Engineering.
    Dwivedi, Satyam
    Ericsson Research.
    Händel, Peter
    KTH, School of Electrical Engineering and Computer Science (EECS), Information Science and Engineering.
    Jaldén, Joakim
    KTH, School of Electrical Engineering and Computer Science (EECS), Information Science and Engineering.
    Clock synchronization over networks - Identifiability of the sawtooth modelManuscript (preprint) (Other academic)
    Abstract [en]

    In this paper, we analyze the two-node joint clocksynchronization and ranging problem. We focus on the case of nodes that employ time-to-digital converters to determine the range between them precisely. This specific design leads to a sawtooth model for the captured signal, which has not been studied in detail before from an estimation theory standpoint. In the study of this model, we recover the basic conclusion of a well-known article by Freris, Graham, and Kumar in clock synchronization. Additionally, we discover a surprising identifiability result on the sawtooth signal model: noise improves the theoretical condition of the estimation of the phase and offset parameters. To complete our study, we provide performance references for joint clock synchronization and ranging. In particular, we present the Cramér-Rao lower bounds that correspond to a linearization of our model, as well as a simulation study on the practical performance of basic estimation strategies under realistic parameters. With these performance references, we enable further research in estimation strategies using the sawtooth model and pave the path towards industrial use.

  • Johansson, Hans
    Stockholm University, Faculty of Science, Department of Physical Geography.
    Towards a Holocene tephrochronology for the Azores2015Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    The Azores is situated in the North Atlantic Ocean and is one of the most active volcanicregions in the Northern Hemisphere. The volcanic history of the islands is fairly wellknown and several explosive trachytic eruptions have been reported but the geochemicalcompositions of the glass component of the tephra as well as the dispersal oftephras to distal areas are less well known. The purpose of this study is twofold: (1) topresent major element geochemistry of the glass component from several historic aswell as prehistoric tephras, including the trachybasaltic Capelinhos AD 1957‐58eruption on the island of Faial, and the trachytic explosive eruptions of Sete Cidades(c. AD 1440), Fogo A (c. 5000 BP), Fogo AD 1563 and Furnas AD 1630 on the island ofSão Miguel; (2) to present a refined tephrostratigraphy for the island of Pico. Analyses ofmajor element geochemistry suggest that tephras from the three active stratovolcanoeson São Miguel can be separated in biplots showing e.g. FeOtot vs.TiO2 and FeOtot vs. CaO.The tephrostratigraphy of Caveiro bog on the island of Pico is based on a radiocarbondated core with eight tephra layers extending back to c. 7000 BP. All tephras are oftrachybasaltic/basaltic trachyandesitic composition except the oldest layer, which is ofbasanitic composition. An attempt was made to correlate the tephra record of Caveirobog with the previously investigated Lake Caveiro. A tephra‐based correlation betweenthe Caveiro bog and Lake Caveiro is not straightforward and only three tephras inCaveiro bog can possibly be correlated with tephras found in the sediments of LakeCaveiro.Proximal glass data from the Furnas volcano on São Miguel suggest that distal cryptotephrasfound in Ireland may have an origin in the Azores and not on Jan Mayen aspreviously has been suggested. The similarity of the proximal tephras on São Miguel anddistal tephras in Ireland is demonstrated by high similarity coefficients (>0.95) andbiplots showing major element composition also support a correlation between Azoreaneruptions and distal tephras in Ireland. Thus, trachytic tephras erupted from explosiveeruptions on the island of São Miguel may have a potential to contribute to theconstruction of a European‐wide tephrochronology framework.Trachytic tephras erupted from explosive eruptions on the Azores may be more widelydispersed than previously thought and may provide useful isochrones for correlation ofpaleoclimate archives in the north‐central Atlantic, North Africa and the Iberian regions.The trachybasaltic/basaltic trachyandesitic tephras erupted from cinder cones on PicoIsland are probably only useful for a local tephrochronology in the Azores region, andnot for a wider Atlantic or European framework.

  • Doyle, Siamsa M.
    et al.
    Rigal, Adeline
    Grones, Peter
    Karady, Michal
    Barange, Deepak Kumar
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Majda, Mateusz
    Parizkova, Barbora
    Karampelias, Michael
    Zwiewka, Marta
    Pencik, Ales
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Almqvist, Fredrik
    Ljung, Karin
    Novak, Ondrej
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Robert, Stephanie
    A role for the auxin precursor anthranilic acid in root gravitropism via regulation of PIN‐FORMED protein polarity and relocalisation in Arabidopsis2019In: New Phytologist, ISSN 0028-646X, E-ISSN 1469-8137, Vol. 223, no 3, p. 1420-1432Article in journal (Refereed)
    Abstract [en]

    Distribution of auxin within plant tissues is of great importance for developmental plasticity, including root gravitropic growth. Auxin flow is directed by the subcellular polar distribution and dynamic relocalisation of auxin transporters such as the PIN‐FORMED (PIN) efflux carriers, which can be influenced by the main natural plant auxin indole‐3‐acetic acid (IAA). Anthranilic acid (AA) is an important early precursor of IAA and previously published studies with AA analogues have suggested that AA may also regulate PIN localisation.

    Using Arabidopsis thaliana as a model species, we studied an AA‐deficient mutant displaying agravitropic root growth, treated seedlings with AA and AA analogues and transformed lines to over‐produce AA while inhibiting its conversion to downstream IAA precursors.

    We showed that AA rescues root gravitropic growth in the AA‐deficient mutant at concentrations that do not rescue IAA levels. Overproduction of AA affects root gravitropism without affecting IAA levels. Treatments with, or deficiency in, AA result in defects in PIN polarity and gravistimulus‐induced PIN relocalisation in root cells.

    Our results revealed a previously unknown role for AA in the regulation of PIN subcellular localisation and dynamics involved in root gravitropism, which is independent of its better known role in IAA biosynthesis.

  • Hermann, Robert
    et al.
    Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany.
    Litwin, Jeffrey S.
    WCG Clin, Princeton, NJ USA.
    Friberg, Lena E.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Dangond, Fernando
    EMD Serono Inc, Billerica, MA USA.
    Munafo, Alain
    Merck Inst Pharmacometr, Quantitat Pharmacol, Lausanne, Switzerland.
    Effects of cladribine tablets on heart rate, atrio-ventricular conduction and cardiac repolarization in patients with relapsing multiple sclerosis2019In: British Journal of Clinical Pharmacology, ISSN 0306-5251, E-ISSN 1365-2125, Vol. 85, no 7, p. 1484-1494Article in journal (Refereed)
    Abstract [en]

    Aims Cladribine tablets have shown significant efficacy for the treatment of relapsing multiple sclerosis, a chronic and debilitating immune-mediated disorder. This study was conducted to examine acute and/or cumulative effects of cladribine tablets 10 mg (3.5 or 5.25 mg/kg cumulative dose over 2 years) on heart rate, AV conduction and cardiac repolarization in patients with relapsing-remitting multiple sclerosis (RRMS). Methods CLARITY was a 96-week, double-blind, placebo-controlled, multicentre trial which evaluated the safety and efficacy of cladribine tablets 3.5 and 5.25 mg/kg body weight in patients with RRMS. A total of 135 patients were included in the ECG substudy, providing a total of 1534 post-dose ECGs. ECG data were collected 15 minutes pre-dose and between 0.5 and 3 hours post-dose at pre-study evaluation, study Day 1 and Weeks 5, 9, 13, 48 and 52. Results For cladribine tablets 3.5 mg/kg, the maximum change in placebo-adjusted post-dose QTcF vs. visit-baseline (BL) was -0.42 ms (90% CI: -3.61-4.44) at Week 1 (acute effects), and 3.20 ms (90% CI: -0.08-6.33) for cladribine tablets 5.25 mg/kg. The greatest observed differences in post-dose QTcF vs. study BL occurred at Week 48 for both the 3.5 and 5.25 mg/kg doses of cladribine tablets with 5.99 ms (90% CI: 0.53-11.44) and 8.74 ms (90% CI: 3.18-14.31), respectively. No significant changes were observed in T-wave morphology in either treatment group. Conclusions Cladribine tablets 3.5 mg/kg (approved dose in Europe/other regions) did not confer clinically meaningful effects on heart rate, AV conduction and ventricular repolarization.

  • Högvall, Mattias
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
    Vellutini, Bruno C.
    Univ Bergen, Sars Int Ctr Marine Mol Biol, Thormohlensgate 55, N-5006 Bergen, Norway;Max Planck Inst Mol Cell Biol & Genet, Pfotenhauerstr 108, D-01307 Dresden, Germany.
    Martin-Duran, Jose M.
    Univ Bergen, Sars Int Ctr Marine Mol Biol, Thormohlensgate 55, N-5006 Bergen, Norway;Queen Mary Univ London, Sch Biol & Chem Sci, Mile End Rd, London E1 4NS, England.
    Hejnol, Andreas
    Univ Bergen, Sars Int Ctr Marine Mol Biol, Thormohlensgate 55, N-5006 Bergen, Norway.
    Budd, Graham
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
    Janssen, Ralf
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
    Embryonic expression of priapulid Wnt genes2019In: Development, Genes and Evolution, ISSN 0949-944X, E-ISSN 1432-041X, Vol. 229, no 4, p. 125-135Article in journal (Refereed)
    Abstract [en]

    Posterior elongation of the developing embryo is a common feature of animal development. One group of genes that is involved in posterior elongation is represented by the Wnt genes, secreted glycoprotein ligands that signal to specific receptors on neighbouring cells and thereby establish cell-to-cell communication. In segmented animals such as annelids and arthropods, Wnt signalling is also likely involved in segment border formation and regionalisation of the segments. Priapulids represent unsegmented worms that are distantly related to arthropods. Despite their interesting phylogenetic position and their importance for the understanding of ecdysozoan evolution, priapulids still represent a highly underinvestigated group of animals. Here, we study the embryonic expression patterns of the complete sets of Wnt genes in the priapulids Priapulus caudatus and Halicryptus spinulosus. We find that both priapulids possess a complete set of 12 Wnt genes. At least in Priapulus, most of these genes are expressed in and around the posterior-located blastopore and thus likely play a role in posterior elongation. Together with previous work on the expression of other genetic factors such as caudal and even-skipped, this suggests that posterior elongation in priapulids is under control of the same (or very similar) conserved gene regulatory network as in arthropods.

  • Song, Tianyi
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Spillmann, Dorothe
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Transcriptomic analysis reveals cell apoptotic signature modified by heparanase in melanoma cells2019In: Journal of Cellular and Molecular Medicine (Print), ISSN 1582-1838, E-ISSN 1582-4934, Vol. 23, no 7, p. 4559-4568Article in journal (Refereed)
    Abstract [en]

    Heparanase has been implicated in many pathological conditions, especially inflammation and cancer, attributed to its degradation of heparan sulfate, a crucial component maintaining the integrity of the extracellular matrix. By silencing the heparanase gene (HPSE) in MDA-MB-435s melanoma cells, we investigated the impact of this protein on gene transcription. Transcriptome sequencing yielded a list of 279 differentially expressed genes, of which 140 were up-regulated and 239 down-regulated. The 140 up-regulated genes were classified into a substantial set of gene ontology defined functions, for example, positive regulation of cell death, apoptotic process, response to cytokine, while 239 down-regulated genes classify only into the two categories: nucleosome and nucleosome assembly. Our focus was drawn to an array of 28 pro-apoptotic genes regulated by heparanase: real-time PCR experiments further validated up-regulation of EGR1, TXNIP, AXL, CYR61, LIMS2 and TNFRSF12A by at least 1.5-fold, among which EGR1, CYR61, and TNFRSF12A were confirmed on protein level. We demonstrated significantly increased apoptotic cells by TUNEL staining upon HPSE silencing, mediated by activation of caspase 3/PARP1 pathway. The pro-apoptotic gene expression and observation of apoptosis were extended to another melanoma cell line, MV3 cells, thus consolidating the anti-apoptosis effect of heparanase in melanoma cells.

  • Buvailo, Halyna I.
    et al.
    Taras Shevchenko Natl Univ Kyiv, Dept Chem, Volodymyrska 64-13, UA-01601 Kiev, Ukraine.
    Makhankova, Valeriya G.
    Taras Shevchenko Natl Univ Kyiv, Dept Chem, Volodymyrska 64-13, UA-01601 Kiev, Ukraine.
    Kokozay, Vladimir N.
    Taras Shevchenko Natl Univ Kyiv, Dept Chem, Volodymyrska 64-13, UA-01601 Kiev, Ukraine.
    Omelchenko, Irina V.
    Natl Acad Sci Ukraine, Inst Single Crystals, Nauky Ave 60, UA-61001 Kharkov, Ukraine.
    Shishkina, Svitlana V.
    Natl Acad Sci Ukraine, Inst Single Crystals, Nauky Ave 60, UA-61001 Kharkov, Ukraine.
    Jezierska, Julia
    Univ Wroclaw, Inst Chem, F Joliot Curie 14, PL-50383 Wroclaw, Poland.
    Pavliuk, Mariia V.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Shylin, Sergii I.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Copper-containing hybrid compounds based on extremely rare [V2Mo6O26]6- POM as water oxidation catalysts2019In: INORGANIC CHEMISTRY FRONTIERS, ISSN 2052-1553, Vol. 6, no 7, p. 1813-1823Article in journal (Refereed)
    Abstract [en]

    Herein, we report two approaches to the synthesis of heterometallic complexes (NH4)(2n)(H(2)en)(n){[Cu(en)(2)][alpha-V2Mo6O26]}center dot 4nH(2)O (1), (NH4)(2){[Cu(dien)(H2O)](2)[alpha-V2Mo6O26]}center dot 5H(2)O (2) and (NH4)(2){[Cu(dien)(H2O)](2)[alpha-V2Mo6O26]}center dot 8H(2)O (3) that have been employed in homogeneous photochemical oxidation of water to dioxygen. In these hybrid metalorganic-inorganic compounds, copper-containing complex fragments are covalently bound to the rare vanadium-disubstituted alpha-octamolybdate cluster. They exhibit variable catalytic activity controlled by the local coordination environment of copper reaching a notably high turnover frequency of 0.24 s(-1) for 3 in combination with a relatively low water oxidation overpotential. The complexes have been also used as precursors for the preparation of mixed oxide phases that have proven to be active heterogeneous water oxidation catalysts.

  • Yarova, Aliona
    Luleå University of Technology, Department of Arts, Communication and Education, Education, Language, and Teaching.
    “I Am the Eternal Green Man”: Holistic Ecology in Reading Patrick Ness’s A Monster Calls2019In: Children's Literature in Education, ISSN 0045-6713, E-ISSN 1573-1693, p. 1-14Article in journal (Refereed)
    Abstract [en]

    Holistic ecology considers nature and society as a whole, viewing humans and the environment as interdependent and interconnected. This article takes the lens of holistic ecology to examine the representation of human–nature relationships in Patrick Ness’s A Monster Calls (2011) and explores how the novel guides the child reader to an environmental mind-set beyond overt didacticism. The article focuses on two aspects of the bond between the magical tree and the human characters in the novel: how the powerful tree empowers humans and how the human characters contribute to the tree’s expressions of power. The eternal Green Man—as the tree introduces itself—embodies this bond by being simultaneously tree-like and human-like, a complex merger of “the Green” (nature) and “the Man” (humanity). The monster-tree fulfils several powerful and empowering roles, such as monster and storyteller, destructive force and powerful healer, savage and philosopher, nightmare and escape. Importantly, it always keeps the shape of a yew tree. As such, A Monster Calls can contribute to children’s environmental education by illustrating the connection between the natural environment and humans: the eternal bond between “the Green” and “the Man.”

  • Di Gravio, Chiara
    et al.
    Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton Gen Hosp, Tremona Rd, Southampton SO16 6YD, Hants, England.
    Lawande, Ashwin
    Dr Joshi Imaging Clin, Mumbai, Maharashtra, India.
    Potdar, Ramesh D.
    Ctr Study Social Change, Mumbai, Maharashtra, India.
    Sahariah, Sirazul A.
    Ctr Study Social Change, Mumbai, Maharashtra, India.
    Gandhi, Meera
    Ctr Study Social Change, Mumbai, Maharashtra, India.
    Brown, Nick
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH), International Child Health and Nutrition.
    Chopra, Harsha
    Ctr Study Social Change, Mumbai, Maharashtra, India.
    Sane, Harshad
    Ctr Study Social Change, Mumbai, Maharashtra, India.
    Kehoe, Sarah H.
    Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton Gen Hosp, Tremona Rd, Southampton SO16 6YD, Hants, England.
    Marley-Zagar, Ella
    Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton Gen Hosp, Tremona Rd, Southampton SO16 6YD, Hants, England.
    Margetts, Barrie M.
    Univ Southampton, Publ Hlth Nutr, Southampton, Hants, England.
    Jackson, Alan A.
    NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.
    Fall, Caroline H. D.
    Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton Gen Hosp, Tremona Rd, Southampton SO16 6YD, Hants, England.
    The Association of Maternal Age With Fetal Growth and Newborn Measures: The Mumbai Maternal Nutrition Project (MMNP)2019In: Reproductive Sciences, ISSN 1933-7191, E-ISSN 1933-7205, Vol. 26, no 7, p. 918-927Article in journal (Refereed)
    Abstract [en]

    Background: Young maternal age is associated with poorer birth outcomes, but the mechanisms are incompletely understood. Using data from a prospective cohort of pregnant women living in Mumbai slums, India, we tested whether lower maternal age was associated with adverse fetal growth.

    Methods: Fetal crown-rump length (CRL) was recorded at a median (interquartile range, IQR) of 10 weeks' gestation (9-10 weeks). Head circumference (HC), biparietal diameter (BPD), femur length (FL), and abdominal circumference (AC) were recorded at 19 (19-20) and 29 (28-30) weeks. Newborns were measured at a median (IQR) of 2 days (1-3 days) from delivery. Gestation was assessed using prospectively collected menstrual period dates.

    Results: The sample comprised 1653 singleton fetuses without major congenital abnormalities, of whom 1360 had newborn measurements. Fetuses of younger mothers had smaller CRL (0.01 standard deviation [SD] per year of maternal age; 95% confidence interval CI: 0.00-0.02(1); P = .04), and smaller HC, FL, and AC at subsequent visits. Fetal growth of HC (0.04 cm; 95% CI: 0.02-0.05; P < .001), BPD (0.01 cm; 95% CI: 0.00-0.01; P = .009), FL (0.04 cm; 95% CI: 0.02-0.06; P < .001), and AC (0.01 cm; 95% CI: 0.00-0.01; P = .003) up to the third trimester increased with maternal age. Skinfolds, head, and mid-upper arm circumferences were smaller in newborns of younger mothers. Adjusting for maternal prepregnancy socioeconomic status, body mass index, height, and parity attenuated the associations between maternal age and newborn size but did not change those with fetal biometry.

    Conclusion: Fetuses of younger mothers were smaller from the first trimester onward and grew slower, independently of known confounding factors.

  • Jannisa, Gudmund
    Kristianstad University, Faculty of Health Science, Avdelningen för samhällsvetenskap.
    Timor-Leste in the World: BC to Independence2019Book (Other academic)
  • Ma, Li
    Stockholm University.
    Female Employment and Fertility Change in South Korea2014Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    A large amount of literature has addressed the relationship between women’s employment and fertility in the Western context. We have less relevant knowledge about the context of East Asia. This thesis addresses this situation by providing insight into how women’s employment is interrelated with their fertility in South Korea. I investigate women’s life-course transitions to motherhood, labor force return after childbearing, and second childbearing, respectively. Data used for my analyses come from the Korea Labor and Income Panel Study (KLIPS).

    My studies show that the traditional practice of leaving the labor market at an early stage of family life has gradually been replaced by a pattern of staying at work until and during pregnancy. Among wage earners, women with stable employment positions are more likely than others to become a mother. Further, women with a good labor market standing are more likely to return to the labor force immediately after childbirth without any career interruption. Still, a considerable number of women shift to homemaking after childbirth. The outbreak of the Asian financial crisis in 1997 pushed mothers to hold tighter to the labor market than before. Labor force participation after first birth depresses women’s likelihood of having a second child.

    These studies suggest that a good labor market standing facilitates both motherhood entry and job continuity after childbirth in South Korea. However, the considerable number of women that shift to homemaking during motherhood and the depressed second birth rates of mothers in the labor force reveal that Korean women still face hardships when trying to combine work and family responsibilities.

  • Vessby, Johan
    Växjö universitet, Institutionen för teknik och design.
    Shear walls for multi-storey timber buildings2008Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    Wind loads acting on wooden building structures need to be dealt with adequately in order to ensure that neither the serviceability limit state nor the ultimate limit state is exceeded. For the structural designer of tall buildings, avoiding the possibly serious consequences of heavy wind loading while taking account at the same time of the effects of gravitation can be a real challenge. Wind loads are usually no major problem for low buildings, such as one- to two-storey timber structures involving ordinary walls made by nailing or screwing sheets of various types to the frame, but when taller structures are designed and built, serious problems may arise.

    Since wind speed and thus wind pressure increases with height above the ground and the shear forces transmitted by the walls increase accordingly, storey by storey, considerable efforts can be needed to handle the strong horizontal shear forces that are exerted on the bottom floor in particular. The strong uplift forces that can develop on the wind side of a structure are yet another matter that can be critical. Accordingly, a structure needs to be anchored to the substrate or to the ground by connections that are properly designed. Since the calculated uplift forces depend very much upon the models employed, the choice of models and simplifications in the analysis that are undertaken also need to be considered carefully.

    The present licentiate thesis addresses questions of how wind loads acting on multi-storey timber buildings can be best dealt with and calculated for in the structural design of such buildings. The conventional use of sheathing either nailed or screwed to a timber framework is considered, together with other methods of stabilizing timber structures. Alternative ways of using solid timber elements for stabilization are also of special interest.

    The finite element method was employed in simulating the structural behaviour of stabilizing units. A study was carried out of walls in which sheathing was nailed onto a timber frame. Different structural levels were involved, extending from modelling the performance of a single fastener and of the connection of the sheathing to frame, to the use of models of this sort for studying the overall structural behaviour of wall elements that possess a stabilizing function. The results of models used for simulating different load cases for walls agreed reasonably well with experimental test results. The structural properties of the fasteners binding the sheathing to the frame, as well as of the connections between the members of the frame were shown to have a strong effect on the simulated behaviour of shear wall units.

    Regarding solid wall panels, it was concluded that walls with a high level of both stiffness and strength can be produced by use of such panels, and also that the connections between the solid wall panels can be designed in such a way that the shear forces involved are effectively transmitted from one panel to the next.

  • Vessby, Johan
    Linnéuniversitetet, Institutionen för teknik, TEK.
    Analysis of shear wallsfor multi-storey timber buildings2011Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This doctoral thesis addresses questions of how wind loads acting on multistoreytimber buildings can be dealt with by structural design of such buildings.The conventional use of sheathing either nailed or screwed to a timberframework is considered, together with other stabilizing structures such ascross-laminated timber panels.The finite element method was employed in simulating the structuralbehaviour of stabilizing wall units. A series of studies was carried out of walls inwhich the sheathing was nailed to a timber frame. Different structural levelswere studied starting with modelling the performance of single sheathing-toframingconnections, to the use of models for studying the overall structuralbehaviour of walls. The results of calculations using models for simulation ofwalls subjected to different loading agree reasonably well with experimentalresults. The structural properties of the connections between the sheathing andthe frame, as well as of the connections between the members of the frame,were shown to have a substantial effect on the simulated behaviour of shearwall units. Both these types of connections were studied and described inappended papers.Regarding cross-laminated timber wall panels, it was concluded that walls witha high level of both stiffness and strength can be produced by the use of suchpanels, and also that the connections between the solid wall panels can bedesigned in such a way that the shear forces involved are transmitted from onepanel to the next in an efficient manner.Other topics in the thesis include the properties of connections between shearwalls and the rest of the building. Typically high tension forces occur at specificpoints in a timber structure. These forces need to be transmitted downwards inthe structure, ultimately connecting them to the substrate. A lap-joint that maybe used for this purpose has been studied using generalized Volkersen theory.Finally the maximum capacity of a conventional rail to substrate connection hasbeen examined using linear and nonlinear fracture mechanics.

  • Lindqvist, Henrik
    et al.
    Linköping University, Department of Behavioural Sciences and Learning, Education, Teaching and Learning. Linköping University, Faculty of Educational Sciences.
    Weurlander, Maria
    Department of Learning in Engineering Sciences, KTH Royal Institute of Technology, Stockholm, Sweden; CLINTEC, Karolinska Institutet, Stockholm, Sweden.
    Wernerson, Annika
    CLINTEC, Karolinska Institutet, Stockholm, Sweden.
    Thornberg, Robert
    Linköping University, Department of Behavioural Sciences and Learning, Education, Teaching and Learning. Linköping University, Faculty of Educational Sciences.
    Boundaries as a coping strategy: emotional labour and relationship maintenance in distressing teacher education situations2019In: European Journal of Teacher Education, ISSN 0261-9768, E-ISSN 1469-5928Article in journal (Refereed)
    Abstract [en]

    ABSTRACTStudent teachers have to cope with distressing emotions during teacher education. Coping is important in relation to both attrition and bridging the gap between being a student teacher and starting work. The data consist of semi-structured interviews with 25 student teachers, which were analysed using a constructivist grounded theory framework. The aim of the current study was to examine student teachers? perspectives on distressing situations during teacher education, as well as how boundaries were established as a way of coping with emotions related to these situations. The findings show that the student teachers? main concern was to make sense of the imbalance between resources and the demands placed by distressing situations. As a coping strategy, student teachers established professional boundaries linked to emotional labour and relationship maintenance.

  • Stenberg, Jenny
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Renal Medicine.
    Melin, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Renal Medicine.
    Lindberg, Magnus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Caring Sciences. Univ Gavle, Dept Hlth & Caring Sci, Gavle, Sweden.
    Furuland, Hans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Renal Medicine.
    Brain natriuretic peptide reflects individual variation in hydration status in hemodialysis patients2019In: Hemodialysis International, ISSN 1492-7535, E-ISSN 1542-4758, Vol. 23, no 3, p. 402-413Article in journal (Refereed)
    Abstract [en]

    Introduction: Fluid management in hemodialysis patients is a controversial topic. Brain natriuretic peptide (BNP) is secreted from the heart in response to volume overload, and may be a marker of overhydration in hemodialysis patients. Our aim was to investigate the correlation between BNP and overhydration in a cohort of hemodialysis patients, and to find out whether BNP and overhydration correlate in repeated measurements within individuals with elevated BNP.

    Methods: The study was prospective, observational, and had a cross-sectional part and a longitudinal follow-up. The distribution of BNP was investigated in a cohort of 64 hemodialysis patients. Blood samples and bioimpedance spectroscopy measurements were performed before midweek dialysis. Subsequently, 11 study participants with elevated BNP concentrations (>500 pg/mL) were assessed in another nine dialysis sessions each. These individuals also had their cardiac function and heart rate variability (HRV) examined.

    Findings: BNP was above 500 pg/mL in 38% of the participants, and correlated positively with overhydration (r(s) = 0.381), inflammation and malnutrition, but not with systolic blood pressure. In comparison to participants with BNP below 500 pg/mL, participants with elevated BNP were older, had lower muscle strength, lower bodyweight and lower levels of hemoglobin and albumin. Echocardiography revealed cardiac anomalies in all 11 participants in the longitudinal follow-up, and HRV, as measured by SDNN, was pathologically low. In repeated measurements, the between-individuals variation of BNP in relation to overhydration was greater (SD = 0.581) than the within-person variation (SD = 0.285).

    Discussion: BNP correlates positively to overhydration, malnutrition, and inflammation. In a subgroup of patients with elevated BNP, who are mainly elderly and frail, BNP reflects individual variation in hydration status, and hence seems to be a modifiable marker of overhydration. These data suggest that BNP is best applied for measuring changes in hydration status within an individual over time.

  • Farhang, Mehdy
    et al.
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Orthopaedics.
    Mukka, Sebastian
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Orthopaedics.
    Bergström, Ulrica
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Orthopaedics.
    Svensson, Olle
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Orthopaedics.
    Sayed-Noor, Arkan S.
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Orthopaedics.
    The trend of radiological severity of hip fractures over a 30 years period: a cohort study2019In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 20, no 1, article id 358Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Despite advances in operative techniques and preoperative care, proximal femur fractures (PFF) still represent a great public health problem. Displacement and fracture stability have been assumed as important determinants of treatment modality and outcome in such fractures. Purpose of this study was to determine whether the radiological severity of PFF fractures has increased over time.

    METHODS: In a cohort study, the plain radiographs of all patients with PFF aged over 50 years who were admitted to Umeå University Hospital in 1981/82, 2002 and 2012 were recruited to examine the types of fractures.

    RESULTS: The ratio of undisplaced to displaced femoral neck (FN) fractures was 30 to 70% in 1981/82, 28 to 72% in 2002 and 25 to 75% in 2012. The ratio of stable to unstable intertrochanteric (IT) fractures was 64 to 36% in 1981/82, 68 to 32% in 2002 and 75 to 25% in 2012. The ratio of simple to comminute subtrochanteric fractures was 35 to 65% in 1981/82, 16 to 84% in 2002 and 12 to 88% in 2012. In both FN and IT fractures we found no statistical difference among these 3 study periods, p = 0.67 and p = 0.40. In subtrochanteric fractures we saw a tendency towards more comminute subtrochanteric fractures (1981/82 to 2012), p = 0.09.

    CONCLUSIONS: We found no significant increment in the radiological severity of FN and IT over a 30 years' period. However, there was tendency towards an increase in comminute subtrochanteric fractures.

  • Weissmann, Mikael
    et al.
    Swedish Defence University, Department of Military Studies, Tactical Warfare Division, Land Operations Section.
    Björnehed, Emma
    Swedish Defence University, Department of Military Studies, Tactical Warfare Division, Maritime Operations Section.
    Praktisk examination och examination av praktik: Möjligheter och begränsningar2019In: Kungl Krigsvetenskapsakademiens Handlingar och Tidskrift, ISSN 0023-5369, no 2, p. 91-103Article in journal (Other academic)
    Abstract [en]

    The ability to lead armed combat is central to an officer. It is clear that the military professionis about more than possessing theoretical knowledge. Thus, in order to achieve an educationalprogram that includes the skills and abilities of the military profession there is a need to lookbeyond traditional written examination and apply practical examination in various forms.In this article we argue that while all practice can and should be examined through practicalexamination, not everything that is practically examined has to be practice. More specifically,this article will focus on the possibilities and limitations with practical examination. Focuswill be on the education of officers within the context of war studies. The article approachesthe issue on the basis of the legal framework for higher education in Sweden, research onteaching and learning in higher education and practice at the Swedish Defence University. Theoverall purpose is to understand practical examination with regard to what is allowed, howit is done with judicial security, and how it can be done in practice. The article also discusseswhat should be practically examined and how this should be done.

  • Jalilzadehazhari, Elaheh
    et al.
    Linnaeus University, Faculty of Technology, Department of Forestry and Wood Technology.
    Pardalis, Georgios
    Linnaeus University, Faculty of Technology, Department of Built Environment and Energy Technology.
    Vadiee, Amir
    Mälardalen University, Sweden.
    Mahapatra, Krushna
    Linnaeus University, Faculty of Technology, Department of Built Environment and Energy Technology.
    Profitability of various energy supply systems when renovating a single-family house in Sweden: case study2019In: International Conference on Applied Energy (ICAE 2019). August 12-15, Västerås, Sweden, 2019Conference paper (Refereed)
    Abstract [en]

    The majority of single-family houses in Sweden are affected by deteriorations in building envelopes as well as heating, ventilation and air conditioning systems, since they are about 30 years old. Theses house are therefore in need of extensive renovation, which provides an excellent opportunity to incorporate energy efficiency measures to reduce both the energy consumption and also operational. Although former studies analyzed the cost effectiveness of various renovation packages, they mainly excluded the evaluation of energy price implications on cost effectiveness of different renovation package in Sweden. Accordingly, this study considers three energy prices and quantifies the payback period (PBP) and internal rate of return (IRR) of the packages, when renovating a single-family house in Sweden. The renovation packages included three distinct energy supply systems, commonly installed when implementing energy renovations: ground source heat pump (GSHP), photovoltaic solar panels (PV), and an integrated GSHP and PV system. The analyses of results show that a the GSHP system provides higher IRR and the lowest PBP compared to the other two renovation packages, due to its high performance in reducing energy consumption and its relatively low investment cost. Furthermore, results show that raising the energy price can increase the IRR and reduce the PBP of the renovation packages and respectively. Moreover, increasing the interest rate adds on PBP of renovation packages, since it depreciates the cost for saved energy. 

  • Jalilzadehazhari, Elaheh
    et al.
    Linnaeus University, Faculty of Technology, Department of Forestry and Wood Technology.
    Vadiee, Amir
    Mälardalen University, Sweden.
    Johansson, Peter
    Jönköping University, Sweden.
    The profitability of various energy supply systems considering variations in future climate conditions2019In: International Conference on Applied Energy (ICAE 2019). August 12-15, Västerås, Sweden, 2019Conference paper (Refereed)
    Abstract [en]

    Ambitious targets were set in Sweden to increase the share of renewable energy resources and reduce greenhouse gas emissions. Renovating old detached houses can assist in achieving the abovementioned targets, since they make up a great share of the final energy consumption and carbon dioxide emissions in Sweden. Although, several attempts were taken to improve the energy performance of the detached houses, the implementation of energy efficient renovation is yet low due to mainly high investment cost. Former studies evaluated the cost effectiveness of various energy efficient renovations in renovating detached houses in Sweden, but they provided no information how possible climate futures affect the determination and adoption of energy efficiency policies, such as monetary instruments. Accordingly, this study considered three distinct energy renovation packages and analyzed the subsidies required for implementing renovation packages for given interest rates and lifetimes. Furthermore, three different climate scenarios were considered to analyze the effect of possible climate futures on subsidies required. The analyses of results show that increasing the lifetime have greater impact on required subsidies than increasing the interest rate. Furthermore, the results show that variation in future climate conditions changes the required subsidies when implementing energy efficiency renovations. Results can be used as an aid when adopting energy efficiency policies. 

  • Syssner, Josefina
    Linköping University, Department for Studies of Social Change and Culture, Centre for Municipality Studies – CKS. Linköping University, Faculty of Arts and Sciences.
    Varför längtar vi till skogen?2018Book (Other (popular science, discussion, etc.))
    Abstract [sv]

    VARFÖR LÄNGTAR VI TILL SKOGEN? är en bildsvit och en samling röster om skogen. Här förenas längtan efter fjällskogar, myrmarker och nordisk blandskog med längtan efter lugn och stillhet, samhörighet och frihet, rörelseglädje, adrenalin och arbetsvilja. I boken ger jägare, skogsbrukare, orienterare, naturguider och andra med skogen i hjärtat sina personliga perspektiv på just skog. Josefina Syssner fångar skogens mångfald och föränderlighet i enkla och stundtals naivistiska teckningar i blyerts och tusch.

    JOSEFINA SYSSNER är forskare och författare. Hon har gett ut tre monografier, varit redaktör för sex antologier och publicerat en lång rad vetenskapliga artiklar och rapporter. Syssner har varit forskningsledare i flera stora forskningsprojekt och är en flitigt anlitad föreläsare. Hennes forskning handlar framförallt om lokal utveckling, politik och planering och om landsbygdens framtid. I den här boken publicerar hon för första gången ut en del av sin omfattande bildproduktion - en bildsvit om skogen i blyerts och tusch.

  • Mansouri, Masoumeh
    et al.
    Örebro University, School of Science and Technology.
    Lacerda, Bruno
    Oxford Robotics Institute, University of Oxford, UK.
    Hawes, Nick
    Oxford Robotics Institute, University of Oxford, UK.
    Pecora, Federico
    Örebro University, School of Science and Technology.
    Multi-Robot Planning Under Uncertain Travel Times and Safety Constraints2019In: Proceedings of the Twenty-Eighth International Joint Conference on Artificial Intelligence (IJCAI-19), 2019, p. 478-484Conference paper (Refereed)
    Abstract [en]

    We present a novel modelling and planning approach for multi-robot systems under uncertain travel times. The approach uses generalised stochastic Petri nets (GSPNs) to model desired team behaviour, and allows to specify safety constraints and rewards. The GSPN is interpreted as a Markov decision process (MDP) for which we can generate policies that optimise the requirements. This representation is more compact than the equivalent multi-agent MDP, allowing us to scale better. Furthermore, it naturally allows for asynchronous execution of the generated policies across the robots, yielding smoother team behaviour. We also describe how the integration of the GSPN with a lower-level team controller allows for accurate expectations on team performance. We evaluate our approach on an industrial scenario, showing that it outperforms hand-crafted policies used in current practice.

  • Vorobyeva, Anzhelika
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Schulga, Alexey
    Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Mol Immunol Lab, Moscow, Russia.
    Konovalova, Elena
    Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Mol Immunol Lab, Moscow, Russia.
    Guler, Rezan
    KTH Royal Inst Technol, Sch Engn Sci Chem Biotechnol & Hlth, Dept Prot Sci, Stockholm, Sweden.
    Lofblom, John
    KTH Royal Inst Technol, Sch Engn Sci Chem Biotechnol & Hlth, Dept Prot Sci, Stockholm, Sweden.
    Sandström, Mattias
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Garousi, Javad
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Chernov, Vladimir
    Russian Acad Sci, Tomsk Natl Res Med Ctr, Canc Res Inst, Nucl Med Dept, Tomsk, Russia.
    Bragina, Olga
    Russian Acad Sci, Tomsk Natl Res Med Ctr, Canc Res Inst, Nucl Med Dept, Tomsk, Russia.
    Orlova, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Theranostics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Deyev, Sergey M.
    Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Mol Immunol Lab, Moscow, Russia;Natl Res Tomsk Polytech Univ, Tomsk, Russia;Natl Res Nucl Univ MEPhI, Inst Engn Phys Biomed PhysBio, Bionanophoton Lab, Moscow, Russia.
    Optimal composition and position of histidine-containing tags improves biodistribution of Tc-99m-labeled DARP in G32019In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 9405Article in journal (Refereed)
    Abstract [en]

    Radionuclide molecular imaging of HER2 expression in disseminated cancer enables stratification of patients for HER2-targeted therapies. DARP in G3, a small (14 kDa) engineered scaffold protein, is a promising probe for imaging of HER2. We hypothesized that position (C- or N-terminus) and composition (hexahistidine or (HE)(3)) of histidine-containing tags would influence the biodistribution of [Tc-99m]Tc(CO)(3)-labeled DARP in G3. To test the hypothesis, G3 variants containing tags at N-terminus (H-6-G3 and (HE)(3)-G3) or at C-terminus (G3-H-6 and G3-(HE)(3)) were labeled with [Tc-99m]Tc(CO)(3). Labeling yield, label stability, specificity and affinity of the binding to HER2, biodistribution and tumor targeting properties of these variants were compared side-by-side. There was no substantial influence of position and composition of the tags on binding of [Tc-99m]Tc(CO)(3)-labeled variants to HER2. The specificity of HER2 targeting in vivo was confirmed. The tumor uptake in BALB/c nu/nu mice bearing SKOV3 xenografts was similar for all variants. On the opposite, there was a strong influence of the tags on uptake in normal tissues. The tumor-to-liver ratio for [Tc-99m]Tc(CO)(3)-(HE)(3)-G3 was three-fold higher compared to the hexahistidine-tag containing variants. Overall, [Tc-99m]Tc(CO)(3)-(HE)(3)-G3 variant provided the highest tumor-to-lung, tumor-to-liver, tumor-to-bone and tumor-to-muscle ratios, which should improve sensitivity of HER2 imaging in these common metastatic sites.

  • Bastani, Spencer
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics, Uppsala Center for Fiscal Studies. Linnaeus Univ, Dept Econ & Stat, Vaxjo, Sweden;Linnaeus Univ, Ctr Integrat & Discriminat Studies, Vaxjo, Sweden;Uppsala Ctr Labor Studies, Uppsala, Sweden;CESifo, Munich, Germany.
    Blomquist, Sören
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics, Uppsala Center for Fiscal Studies.
    Micheletto, Luca
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics, Uppsala Center for Fiscal Studies. CESifo, Munich, Germany;Univ Milan, Dept Law, Milan, Italy;Bocconi Univ, Dondena Ctr Res Social Dynam, Milan, Italy.
    Nonlinear and piecewise linear income taxation, and the subsidization of work-related goods2019In: International Tax and Public Finance, ISSN 0927-5940, E-ISSN 1573-6970, Vol. 26, no 4, p. 806-834Article in journal (Refereed)
    Abstract [en]

    We investigate how the social welfare gain of subsidizing work-related goods depends on whether the underlying income tax system is linear, piecewise linear or fully nonlinear, focusing on child care services as a paradigmatic example of goods/services that are complements with labor supply. Our quantitative analysis employs an empirically relevant labor supply model and shows that the welfare gain of an optimally chosen subsidy is negligible when the optimal income tax is restricted to be linear but about the same as under fully nonlinear taxation when the optimal income tax is restricted to be piecewise linear. Our findings enhance the policy relevance of the optimal tax argument in favor of providing subsidies to work-related goods and also shed light on the relative welfare gains of employing piecewise linear rather than fully nonlinear income taxes.

  • Lindberg, Terese
    et al.
    Blekinge Inst Technol, Karlskrona, Sweden;Blekinge Ctr Competence, Karlskrona, Sweden;Lund Univ, Lund, Sweden.
    Wimo, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Karolinska Inst, Stockholm, Sweden;Stockholm Univ, Stockholm, Sweden.
    Elmstahl, Solve
    Lund Univ, Lund, Sweden.
    Qiu, Chengxuan
    Karolinska Inst, Stockholm, Sweden;Stockholm Univ, Stockholm, Sweden.
    Bohman, Doris M.
    Blekinge Inst Technol, Karlskrona, Sweden.
    Berglund, Johan Sanmartin
    Blekinge Inst Technol, Karlskrona, Sweden;Blekinge Ctr Competence, Karlskrona, Sweden.
    Prevalence and Incidence of Atrial Fibrillation and Other Arrhythmias in the General Older Population: Findings From the Swedish National Study on Aging and Care2019In: Gerontology and geriatric medicine, E-ISSN 2333-7214, Vol. 5, p. 1-8Article in journal (Refereed)
    Abstract [en]

    Aim: To study the prevalence and cumulative incidence of arrhythmias in the general population of adults aged 60 and older over a 6-year period. Study Design and Setting: Data were taken from the Swedish National Study on Aging and Care (SNAC), a national, longitudinal, multidisciplinary study of the general elderly population (defined as 60 years of age or older). A 12-lead resting electrocardiography (ECG) was performed at baseline and 6-year follow-up. Results: The baseline prevalence of atrial fibrillation (AF) was 4.9% (95% confidence interval [CI] = [4.5%, 5.5%]), and other arrhythmias including ventricular premature complexes (VPCs), supraventricular tachycardia (SVT), and supraventricular extrasystole (SVES) were seen in 8.4% (7.7%, 9.0%) of the population. A first- or second-degree atrioventricular (AV) block was found in 7.1% of the population (95% CI = [6.5%, 7.7%]), and there were no significant differences between men and women in baseline arrhythmia prevalence. The 6-year cumulative incidence of AF was 4.1% (95% CI = [3.5%, 4.9%]), or 6.9/1,000 person-years (py; 95% CI = [5.7, 8.0]). The incidence of AF, other arrhythmias, AV block, and pacemaker-induced rhythm was significantly higher in men in all cohorts except for the oldest. Conclusion: Our data highlight the prevalence and incidence of arrhythmias, which rapidly increase with advancing age in the general population.

  • Weyhenmeyer, Gesa A.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Hartmann, Jens
    Univ Hamburg, Ctr Earth Syst Res & Sustainabil CEN, Inst Geol, Bundesstr 55, D-20146 Hamburg, Germany.
    Hessen, Dag O.
    Univ Oslo, CBA, Dept Biosci, Box 1066, N-0316 Blindern, Norway.
    Kopacek, Jiri
    CAS, Biol Ctr, Inst Hydrobiol, Na Sadkach 7, Ceske Budejovice 37005, Czech Republic.
    Hejzlar, Josef
    CAS, Biol Ctr, Inst Hydrobiol, Na Sadkach 7, Ceske Budejovice 37005, Czech Republic.
    Jacquet, Stephan
    INRA CARRTEL, 75 Bis Ave Corzent, F-74203 Thonon Les Bains, CX, France.
    Hamilton, Stephen K.
    Michigan State Univ, Kellogg Biol Stn, Hickory Corners, MI 49060 USA;Michigan State Univ, Dept Integrat Biol, Hickory Corners, MI 49060 USA;Cary Inst Ecosyst Studies, Millbrook, NY 12545 USA.
    Verburg, Piet
    Natl Inst Water & Atmospher Res, Hamilton, New Zealand.
    Leach, Taylor H.
    Rensselaer Polytech Inst, Dept Biol Sci, Troy, NY 12180 USA.
    Schmid, Martin
    Eawag Swiss Fed Inst Aquat Sci & Technol, Surface Waters Res & Management, Seestr 79, CH-6047 Kastanienbaum, Switzerland.
    Flaim, Giovanna
    Fdn Edmund Mach, Res & Innovat Ctr, Dept Sustainable Agroecosyst & Bioresources, Via E Mach 1, I-38010 San Michele All Adige, Italy.
    Nöges, Tiina
    Estonian Univ Life Sci, Inst Agr & Environm Sci, Kreutzwaldi 5, EE-51014 Tartu, Estonia.
    Nöges, Peeter
    Estonian Univ Life Sci, Inst Agr & Environm Sci, Kreutzwaldi 5, EE-51014 Tartu, Estonia.
    Wentzky, Valerie C.
    Helmholtz Ctr Environm Res, Dept Lake Res, Magdeburg, Germany;Helmholtz Ctr Environm Res, Dept Aquat Ecosyst Anal, Magdeburg, Germany.
    Rogora, Michela
    CNR Water Res Inst, Lgo Tonolli 50, I-28922 Verbania, Italy.
    Rusak, James A.
    Dorset Environm Sci Ctr, Dorset, ON P0A 1E0, Canada.
    Kosten, Sarian
    Radboud Univ Nijmegen, Inst Water & Wetland Res, Dept Aquat Ecol & Environm Biol, NL-6525 AJ Nijmegen, Netherlands.
    Paterson, Andrew M.
    Dorset Environm Sci Ctr, Dorset, ON P0A 1E0, Canada.
    Teubner, Katrin
    Univ Vienna, Dept Limnol & Biol Oceanog, Althanstr 14, A-1090 Vienna, Austria.
    Higgins, Scott N.
    IISD Expt Lakes Area Inc, 111 Lombard Ave Suite 325, Winnipeg, MB R3B 0T5, Canada.
    Lawrence, Gregory
    US Geol Survey, NewYork Water Sci Ctr, Troy, NY 12180 USA.
    Kangur, Kulli
    Estonian Univ Life Sci, Inst Agr & Environm Sci, Ctr Limnol, EE-51117 Tartu, Estonia.
    Kokorite, Ilga
    Univ Latvia, Inst Biol, Miera Str 3, LV-2169 Salaspils, Latvia.
    Cerasino, Leonardo
    Fdn Edmund Mach, Res & Innovat Ctr, Dept Sustainable Agroecosyst & Bioresources, Via E Mach 1, I-38010 San Michele All Adige, Italy.
    Funk, Clara
    US Environm Protect Agcy, Clean Air Markets Div, Washington, DC 20460 USA.
    Harvey, Rebecca
    Vermont Dept Environm Serv, 1 Natl Life Dr, Montpelier, VT USA.
    Moatar, Florentina
    Irstea, 5 Rue Doua, F-69625 Villeurbanne, France.
    de Wit, Heleen A.
    Norwegian Inst Water Res, Gaustadalleen 23, NO-0349 Oslo, Norway.
    Zechmeister, Thomas
    Biol Stn Lake Neusiedl, A-7142 Illmitz, Austria.
    Widespread diminishing anthropogenic effects on calcium in freshwaters2019In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 10450Article in journal (Refereed)
    Abstract [en]

    Calcium (Ca) is an essential element for almost all living organisms. Here, we examined global variation and controls of freshwater Ca concentrations, using 440 599 water samples from 43 184 inland water sites in 57 countries. We found that the global median Ca concentration was 4.0 mg L-1 with 20.7% of the water samples showing Ca concentrations <= 1.5 mg L-1, a threshold considered critical for the survival of many Ca-demanding organisms. Spatially, freshwater Ca concentrations were strongly and proportionally linked to carbonate alkalinity, with the highest Ca and carbonate alkalinity in waters with a pH around 8.0 and decreasing in concentrations towards lower pH. However, on a temporal scale, by analyzing decadal trends in > 200 water bodies since the 1980s, we observed a frequent decoupling between carbonate alkalinity and Ca concentrations, which we attributed mainly to the influence of anthropogenic acid deposition. As acid deposition has been ameliorated, in many freshwaters carbonate alkalinity concentrations have increased or remained constant, while Ca concentrations have rapidly declined towards or even below pre-industrial conditions as a consequence of recovery from anthropogenic acidification. Thus, a paradoxical outcome of the successful remediation of acid deposition is a globally widespread freshwater Ca concentration decline towards critically low levels for many aquatic organisms.

  • Abou-Zeid, M.
    et al.
    Georg August Univ Gottingen, SUB, Pl Gottinger Sieben 1, D-37073 Gottingen, Germany.
    Hull, C. M.
    Imperial Coll London, Blackett Lab, Theory Grp, Prince Consort Rd, London SW7 2AZ, England.
    Lindström, Ulf
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics. Imperial Coll London, Blackett Lab, Theory Grp, Prince Consort Rd, London SW7 2AZ, England.
    Rocek, M.
    SUNY Stony Brook, CN Yang Inst Theoret Phys, Stony Brook, NY 11794 USA.
    T-duality in (2,1) superspace2019In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 6, article id 138Article in journal (Refereed)
    Abstract [en]

    We find the T-duality transformation rules for 2-dimensional (2,1) supersymmetric sigma-models in (2,1) superspace. Our results clarify certain aspects of the (2,1) sigma model geometry relevant to the discussion of T-duality. The complexified duality transformations we find are equivalent to the usual Buscher duality transformations (including an important refinement) together with diffeomorphisms. We use the gauging of sigma-models in (2,1) superspace, which we review and develop, finding a manifestly real and geometric expression for the gauged action. We discuss the obstructions to gauging (2,1) sigma-models, and find that the obstructions to (2,1) T-duality are considerably weaker.

  • Arabi Ardehali, Arash
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics. Inst Res Fundamental Sci IPM, Sch Phys, POB 19395-5531, Tehran, Iran.
    Cardy-like asymptotics of the 4d N=4 index and AdS(5) blackholes2019In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 6, article id 134Article in journal (Refereed)
    Abstract [en]

    Choi, Kim, Kim, and Nahmgoong have recently pioneered analyzing a Cardy-like limit of the superconformal index of the 4d N=4 theory with complexified fugacities which encodes the entropy of the dual supersymmetric AdS(5) blackholes. Here we study the Cardy-like asymptotics of the index within the rigorous framework of elliptic hypergeometric integrals, thereby filling a gap in their derivation of the blackhole entropy function, finding a new blackhole saddle-point, and demonstrating novel bifurcation phenomena in the asymptotics of the index as a function of fugacity phases. We also comment on the relevance of the supersymmetric Casimir energy to the blackhole entropy function in the present context.

  • Towner, Jamie
    et al.
    Univ Reading, Dept Geog & Environm Sci, Reading RG6 6AB, Berks, England.
    Cloke, Hannah L.
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL. Univ Reading, Dept Geog & Environm Sci, Reading RG6 6AB, Berks, England;Univ Reading, Dept Meteorol, Reading RG6 6BB, Berks, England;CNDS, Ctr Nat Hazards & Disaster Sci, S-75236 Uppsala, Sweden.
    Zsoter, Ervin
    Univ Reading, Dept Geog & Environm Sci, Reading RG6 6AB, Berks, England;European Ctr Medium Range Weather Forecasts, Shinfield Pk, Reading RG6 9AX, Berks, England.
    Flamig, Zachary
    Univ Chicago, Ctr Data Intens Sci, Chicago, IL 60637 USA.
    Hoch, Jannis M.
    Univ Utrecht, Dept Phys Geog, POB 80115, NL-3508 TC Utrecht, Netherlands;POB 177, NL-2600 MH Delft, Netherlands.
    Bazo, Juan
    Red Cross Red Crescent Climate Ctr, NL-2521 CV The Hague, Netherlands;UTP, Lima, Peru.
    de Perez, Erin Coughlan
    Columbia Univ, Int Res Inst Climate & Soc, Palisades, NY 10964 USA;Red Cross Red Crescent Climate Ctr, NL-2521 CV The Hague, Netherlands.
    Stephens, Elisabeth M.
    Univ Reading, Dept Geog & Environm Sci, Reading RG6 6AB, Berks, England.
    Assessing the performance of global hydrological models for capturing peak river flows in the Amazon basin2019In: Hydrology and Earth System Sciences, ISSN 1027-5606, E-ISSN 1607-7938, Vol. 23, no 7, p. 3057-3080Article in journal (Refereed)
    Abstract [en]

    Extreme flooding impacts millions of people that live within the Amazon floodplain. Global hydrological models (GHMs) are frequently used to assess and inform the management of flood risk, but knowledge on the skill of available models is required to inform their use and development. This paper presents an intercomparison of eight different GHMs freely available from collaborators of the Global Flood Partnership (GFP) for simulating floods in the Amazon basin. To gain insight into the strengths and shortcomings of each model, we assess their ability to reproduce daily and annual peak river flows against gauged observations at 75 hydrological stations over a 19-year period (1997-2015). As well as highlighting regional variability in the accuracy of simulated streamflow, these results indicate that (a) the meteorological input is the dominant control on the accuracy of both daily and annual maximum river flows, and (b) ground-water and routing calibration of Lisflood based on daily river flows has no impact on the ability to simulate flood peaks for the chosen river basin. These findings have important relevance for applications of large-scale hydrological models, including analysis of the impact of climate variability, assessment of the influence of long-term changes such as land-use and anthropogenic climate change, the assessment of flood likelihood, and for flood forecasting systems.

  • Lona-Durazo, Frida
    et al.
    Univ Toronto, Dept Anthropol, Hlth Sci Complex,Room 352, Mississauga, ON L5L 1C6, Canada.
    Hernandez-Pacheco, Natalia
    Univ La Laguna, Res Unit, Hosp Univ NS de Candelaria, Santa Cruz De Tenerife, Spain;Univ La Laguna, Genom & Hlth Grp, Dept Biochem Microbiol Cell Biol & Genet, Tenerife, Spain.
    Fan, Shaohua
    Univ Penn, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA.
    Zhang, Tongwu
    NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Choi, Jiyeon
    NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Kovacs, Michael A.
    NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Loftus, Stacie K.
    NHGRI, Genet Dis Res Branch, NIH, Bethesda, MD 20892 USA.
    Le, Phuong
    Edwards, Melissa
    Univ Toronto, Dept Anthropol, Hlth Sci Complex,Room 352, Mississauga, ON L5L 1C6, Canada.
    Fortes-Lima, Cesar A.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Human Evolution. Univ Paris Diderot, Evolutionary Anthropol Team, Lab Ecoanthropol & Ethnobiol UMR7206, CNRS,MNHN,Musee Homme, Paris, France.
    Eng, Celeste
    Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA.
    Huntsman, Scott
    Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA.
    Hu, Donglei
    Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA.
    Javier Gomez-Cabezas, Enrique
    Ctr Sociol & Psychol Res, Havana, Cuba.
    Caridad Marin-Padron, Lilia
    Med Univ Havana, Natl Ctr Med Genet, Havana, Cuba.
    Grauholm, Jonas
    Statens Serum Inst, Dept Congenital Disorders, Copenhagen, Denmark.
    Mors, Ole
    Aarhus Univ, Translat Neuropsychiat Unit, Dept Clin Med, Aarhus, Denmark;Aarhus Univ, Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark;Aarhus Univ Hosp, Psychiat Dept, Aarhus, Denmark.
    Burchard, Esteban G.
    Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA.
    Norton, Heather L.
    Univ Cincinnati, Dept Anthropol, Cincinnati, OH USA.
    Pavan, William J.
    NHGRI, Genet Dis Res Branch, NIH, Bethesda, MD 20892 USA.
    Brown, Kevin M.
    NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Tishkoff, Sarah
    Univ Penn, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA;Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA.
    Pino-Yanes, Maria
    Univ La Laguna, Genom & Hlth Grp, Dept Biochem Microbiol Cell Biol & Genet, Tenerife, Spain;Inst Salud Carlos III, CIBER Enfermedades Resp, Madrid, Spain;Univ La Laguna, ITB, Santa Cruz De Tenerife, Spain.
    Beleza, Sandra
    Univ Leicester, Dept Genet & Genome Biol, Coll Life Sci, Leicester, Leics, England.
    Marcheco-Teruel, Beatriz
    Med Univ Havana, Natl Ctr Med Genet, Havana, Cuba.
    Parra, Esteban J.
    Univ Toronto, Dept Anthropol, Hlth Sci Complex,Room 352, Mississauga, ON L5L 1C6, Canada.
    Meta-analysis of GWA studies provides new insights on the genetic architecture of skin pigmentation in recently admixed populations2019In: BMC Genetics, ISSN 1471-2156, E-ISSN 1471-2156, Vol. 20, article id 59Article in journal (Refereed)
    Abstract [en]

    Background: Association studies in recently admixed populations are extremely useful to identify the genetic architecture of pigmentation, due to their high genotypic and phenotypic variation. However, to date only four Genome-Wide Association Studies (GWAS) have been carried out in these populations.

    Results: We present a GWAS of skin pigmentation in an admixed sample from Cuba (N=762). Additionally, we conducted a meta-analysis including the Cuban sample, and admixed samples from Cape Verde, Puerto Rico and African-Americans from San Francisco. This meta-analysis is one of the largest efforts so far to characterize the genetic basis of skin pigmentation in admixed populations (N=2,104). We identified five genome-wide significant regions in the meta-analysis, and explored if the markers observed in these regions are associated with the expression of relevant pigmentary genes in human melanocyte cultures. In three of the regions identified in the meta-analysis (SLC24A5, SLC45A2, and GRM5/TYR), the association seems to be driven by non-synonymous variants (rs1426654, rs16891982, and rs1042602, respectively). The rs16891982 polymorphism is strongly associated with the expression of the SLC45A2 gene. In the GRM5/TYR region, in addition to the rs1042602 non-synonymous SNP located on the TYR gene, variants located in the nearby GRM5 gene have an independent effect on pigmentation, possibly through regulation of gene expression of the TYR gene. We also replicated an association recently described near the MFSD12 gene on chromosome 19 (lead variant rs112332856). Additionally, our analyses support the presence of multiple signals in the OCA2/HERC2/APBA2 region on chromosome 15. A clear causal candidate is the HERC2 intronic variant rs12913832, which has a profound influence on OCA2 expression. This variant has pleiotropic effects on eye, hair, and skin pigmentation. However, conditional and haplotype-based analyses indicate the presence of other variants with independent effects on melanin levels in OCA2 and APBA2. Finally, a follow-up of genome-wide signals identified in a recent GWAS for tanning response indicates that there is a substantial overlap in the genetic factors influencing skin pigmentation and tanning response.

    Conclusions: Our meta-analysis of skin pigmentation GWAS in recently admixed populations provides new insights about the genetic architecture of this complex trait.

  • Urban, Philip
    et al.
    La Tour Hosp, Geneva, Switzerland;Cardiovasc European Res Ctr, Massy, France.
    Mehran, Roxana
    Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
    Colleran, Roisin
    Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.
    Angiolillo, Dominick J.
    Univ Florida, Coll Med, Div Cardiol, Jacksonville, FL USA.
    Byrne, Robert A.
    Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.
    Capodanno, Davide
    Ctr Alte Specialita & Trapianti, Cardiothorac Vasc Dept, Catania, Italy;Univ Catania, Azienda Osped Univ Vittorio Emanuele Policlin, Catania, Italy.
    Cuisset, Thomas
    Ctr Hosp Univ Timone, Dept Cardiol, Marseille, France;Aix Marseille Univ, Fac Med, Ctr Rech Cardiovasc & Nutr, Inserm,Inra, Marseille, France.
    Cutlip, Donald
    Harvard Med Sch, Beth Israel Deaconess Med Ctr, Cardiol Div, Boston, MA 02115 USA.
    Eerdmans, Pedro
    DEKRA Certificat BV, Notified Body, Boston, MA USA.
    Eikelboom, John
    McMaster Univ, Dept Med, Hamilton, ON, Canada.
    Farb, Andrew
    US FDA, Silver Spring, MD USA.
    Gibson, C. Michael
    Baim Inst Clin Res, Brookline, MA USA;Harvard Med Sch, Boston, MA 02115 USA.
    Gregson, John
    London Sch Hyg & Trop Med, London, England.
    Haude, Michael
    Lukaskrankenhaus GmbH, Stadt Kliniken Neuss, Neuss, Germany.
    James, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Kim, Hyo-Soo
    Seoul Natl Univ Hosp, Cardiovasc Ctr, Seoul, South Korea.
    Kimura, Takeshi
    Kyoto Univ, Dept Cardiovasc Med, Grad Sch Med, Kyoto, Japan.
    Konishi, Akihide
    Pharmaceut & Med Devices Agcy, Off Med Devices 1, Tokyo, Japan.
    Laschinger, John
    US FDA, Silver Spring, MD USA.
    Leon, Martin B.
    Columbia Univ, Med Ctr, New York, NY USA;Cardiovasc Res Fdn, New York, NY USA.
    Magee, P. F. Adrian
    US FDA, Silver Spring, MD USA.
    Mitsutake, Yoshiaki
    Pharmaceut & Med Devices Agcy, Off Med Devices 1, Tokyo, Japan.
    Mylotte, Darren
    Univ Hosp, Galway, Ireland;Natl Univ Ireland, Galway, Ireland.
    Pocock, Stuart
    London Sch Hyg & Trop Med, London, England.
    Price, Matthew J.
    Scripps Clin, La Jolla, CA 92037 USA.
    Rao, Sunil V.
    Duke Clin Res Inst, Durham, NC USA.
    Spitzer, Ernest
    Erasmus Univ, Med Ctr, Thoraxctr, Rotterdam, Netherlands;Cardialysis Clin Trial Management & Core Labs, Rotterdam, Netherlands.
    Stockbridge, Norman
    US FDA, Silver Spring, MD USA.
    Valgimigli, Marco
    Univ Bern, Dept Cardiol, Inselspital, Bern, Switzerland.
    Varenne, Olivier
    Hop Cochin, AP HP, Serv Cardiol, Paris, France;Univ Paris 05, Sorbonne Paris Cite, Paris, France.
    Windhoevel, Ute
    Cardiovasc European Res Ctr, Massy, France.
    Yeh, Robert W.
    Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
    Krucoff, Mitchell W.
    Duke Clin Res Inst, Durham, NC USA;Duke Univ, Med Ctr, Durham, NC USA.
    Morice, Marie-Claude
    Cardiovasc European Res Ctr, Massy, France.
    Defining High Bleeding Risk in Patients Undergoing Percutaneous Coronary Intervention: A Consensus Document From the Academic Research Consortium for High Bleeding Risk2019In: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 140, no 3, p. 240-261Article in journal (Refereed)
    Abstract [en]

    Identification and management of patients at high bleeding risk undergoing percutaneous coronary intervention are of major importance, but a lack of standardization in defining this population limits trial design, data interpretation, and clinical decision-making. The Academic Research Consortium for High Bleeding Risk (ARC-HBR) is a collaboration among leading research organizations, regulatory authorities, and physician-scientists from the United States, Asia, and Europe focusing on percutaneous coronary intervention-related bleeding. Two meetings of the 31-member consortium were held in Washington, DC, in April 2018 and in Paris, France, in October 2018. These meetings were organized by the Cardiovascular European Research Center on behalf of the ARC-HBR group and included representatives of the US Food and Drug Administration and the Japanese Pharmaceuticals and Medical Devices Agency, as well as observers from the pharmaceutical and medical device industries. A consensus definition of patients at high bleeding risk was developed that was based on review of the available evidence. The definition is intended to provide consistency in defining this population for clinical trials and to complement clinical decision-making and regulatory review. The proposed ARC-HBR consensus document represents the first pragmatic approach to a consistent definition of high bleeding risk in clinical trials evaluating the safety and effectiveness of devices and drug regimens for patients undergoing percutaneous coronary intervention.

  • Ny, Sofia
    et al.
    Karolinska Inst, Dept Lab Med, Div Clin Microbiol, Alfred Nobels Alle 10, S-14152 Stockholm, Sweden;Publ Hlth Agcy Sweden, Nobels Vag 18, S-17182 Stockholm, Sweden.
    Sandegren, Linus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Salemi, Marco
    Univ Florida, Dept Pathol, Emerging Pathogens Inst, POB 100009, Gainesville, FL 32610 USA.
    Giske, Christian G.
    Karolinska Inst, Dept Lab Med, Div Clin Microbiol, Alfred Nobels Alle 10, S-14152 Stockholm, Sweden.
    Genome and plasmid diversity of Extended-Spectrum beta-Lactamase-producing Escherichia coli ST131-tracking phylogenetic trajectories with Bayesian inference2019In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 10291Article in journal (Refereed)
    Abstract [en]

    Clonal lineages of ESBL (Extended-Spectrum beta-Lactamase)-producing E. coli belonging to sequence type 131 (ST131) have disseminated globally during the last 30 years, leading to an increased prevalence of resistance to fluoroquinolones and extended-spectrum cephalosporins in clinical isolates of E. coli. We aimed to study if Swedish ESBL-producing ST131 isolates originated from single or multiple introductions to the population by assessing the amount of genetic variation, on chromosomal and plasmid level, between Swedish and international E. coli ST131. Bayesian inference of Swedish E. coli ST131 isolates (n = 29), sequenced using PacBio RSII, together with an international ST131 dataset showed that the Swedish isolates were part of the international ST131 A, C1 and C2 clades. Highly conserved plasmids were identified in three clusters although they were separated by several years, which indicates a strong co-evolution between some ST131 lineages and specific plasmids. In conclusion, the tight clonal relationship observed within the ST131 clades, together with highly conserved plasmids, challenges investigation of strain transmission events. A combination of few SNPs on a genome-wide scale and an epidemiological temporospatial link, are needed to track the spread of the ST131 subclones.

  • Sejkot, Petr
    et al.
    Linnéuniversitetet, Institutionen för byggteknik (BY).
    Ormarsson, Sigurdur
    Linnéuniversitetet, Institutionen för byggteknik (BY).
    Vessby, Johan
    Linnéuniversitetet, Institutionen för byggteknik (BY).
    Numerical and experimental study of punched metal plate connection used for long-span pitched timber roof truss structure2018In: WCTE 2018 - World Conference on Timber Engineering, World Conference on Timber Engineering (WCTE) , 2018Conference paper (Refereed)
    Abstract [en]

    According to the harmonized European design code for timber structures, Eurocode 5, all pitched timber trusses used in load bearing roofs are designed as in-plane structures which means that a bracing system must be designed and put in place to prevent the out-of-plane instability. Results from numerical 3D stability analyses of the whole roof structure indicate that the out of plane stability is often the critical factor. Therefore, influence of stiffness properties of that system is studied in detail herein for long-span timber roofs. Focus is put on how the stiffness of the mechanical connections in the roof structure influences the load carrying capacity of the roof. The punched metal plate connections are modelled as non-coupled spring elements connecting the various beam elements in the timber truss respectively. The spring stiffness of the connections is derived from full-scale tests, which were made for all in- and out-of-plane degrees of freedom. To evaluate the experimental testing, a digital image correlation method was used. The results from the digital image correlation tests were compared with numerical simulations of the experimentally tested connections to check the potential of using the numerical simulations instead of the experimental testing to get the stiffness properties of various connections used in the whole roof stability analysis. Based on such analysis, punched metal plate fasteners showed to be an important contributor to the roof stability because of its relatively high stiffness in all six degrees of freedom.

  • Robinson, Darrel
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Tannenberg, Marcus
    Univ Gothenburg, Dept Polit Sci, Gothenburg, Sweden.
    Self-censorship of regime support in authoritarian states: Evidence from list experiments in China2019In: Res Rhetorica, ISSN 1652-8581, E-ISSN 2053-1680, Vol. 6, no 3, article id UNSP 2053168019856449Article in journal (Refereed)
    Abstract [en]

    The study of popular support for authoritarian regimes has long relied on the assumption that respondents provide truthful answers to surveys. However, when measuring regime support in closed political systems there is a distinct risk that individuals are less than forthright due to fear that their opinions may be made known to the public or the authorities. In order to test this assumption, we conducted a novel web-based survey in China in which we included four list experiments of commonly used items in the comparative literature on regime support. We find systematic bias for all four measures; substantially more individuals state that they support the regime with direct questioning than when presented with our indirect list experiments. The level of self-censorship, which ranges from 24.5 to 26.5 percentage points, is considerably higher than previously thought. Self-censorship is further most prevalent among the wealthy, urban, female and younger respondents.

  • Vessby, Johan
    et al.
    Växjö universitet, Institutionen för teknik och design.
    Enquist, Bertil
    Växjö universitet, Institutionen för teknik och design.
    Petersson, Hans
    Växjö universitet, Institutionen för teknik och design.
    Alsmarker, Tomas
    Tyréns.
    Experimental study of cross-laminated timber wall panels2009In: European Journal of Wood and Wood Products, ISSN 0018-3768, E-ISSN 1436-736X, Vol. 67, no 2, p. 211-218Article in journal (Refereed)
    Abstract [en]

    The use of cross-laminated structural timber elementsis becoming increasingly popular. The number of layersvaries normally from three upwards. The structural performanceof five-layer cross-laminated timber elements was investigated.The five layers consisted of 19mm thick boards,laid successively at right angles to each other and gluedtogether with PU-adhesive, layers 1, 3 and 5 lying in onedirection and layers 2 and 4 in the other. The stiffness andstrength of four cross-laminated timber elements (4955mmlong, 1250mm wide and 96mm thick) were studied duringin-plane bending. Two of the elements were first partitionedinto two parts that were reconnected in two different waysprior to testing. The influence of the way in which the crosslaminatedtimber elements were reconnected was studied,the behaviour observed being compared with the test resultsfor the unpartitioned specimens with respect to both strengthand stiffness. The experimental tests performed showed thecross-laminated timber elements to possess a high degree ofstiffness and strength. There was also found to be a markeddifference in behaviour between the two different ways inwhich the elements were connected to each other. One of thetwo connecting methods studied, being of less good designbut earlier frequently used in Sweden, showed as expectedpoor structural performance, whereas the other one appliedas a safer alternative performed well.

  • Alehagen, Urban
    et al.
    Linkoping Univ, Div Cardiovasc Med, Fac Med & Hlth Sci, SE-58185 Linkoping, Sweden.
    Wågsäter, Dick
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Gender difference and genetic variance in lipoprotein receptor-related protein 1 is associated with mortality2019In: BIOMEDICAL REPORTS, ISSN 2049-9434, Vol. 11, no 1, p. 3-10Article in journal (Refereed)
    Abstract [en]

    Cardiovascular diseases are an important health resource problem and studies have shown a genetic association between single nucleotide polymorphisms (SNPs) and cardiovascular diseases. According to the literature, lipoprotein receptor-related protein 1 (LRP1) is associated with coronary artery disease. The aim of the present study was to evaluate a possible association between different genotypes of LRP1 and all-cause and cardiovascular mortality from a gender perspective. In the present study, 489 elderly community-living people were invited to participate. Clinical examination, echocardiography and blood sampling including SNP analyses of LRP1 (rs1466535) were performed, including the T/T, C/T and C/C genotypes, and the participants were followed for 6.7 years. During the follow-up period, 116 (24%) all-cause and 75 (15%) cardiovascular deaths were registered. In the female population, the LRP1 of the T/T or C/T genotype exhibited a 5.6-fold increased risk of cardiovascular mortality and a 2.8-fold increased risk of all-cause mortality compared with the C/C genotype. No such genotype differences could be seen in the male population. Gender differences could be seen regarding the risk of mortality in the different genotypes. Females with the LRP1 T/T or C/T genotypes exhibited a significantly increased risk of both all-cause and cardiovascular mortality compared with the C/C genotypes. Therefore, more individualized cardiovascular prevention and treatment should be prioritized. However, since this was a small study, the observations should only be regarded as hypothesis-generating.

  • Müller, Matias I.
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Automatic Control.
    Rojas, Cristian R.
    KTH, School of Electrical Engineering and Computer Science (EECS), Automatic Control.
    Gain estimation of linear dynamical systems using Thompson Sampling2019In: Proceedings of Machine Learning Research / [ed] Kamalika Chaudhuri, Masashi Sugiyama, 2019, Vol. 89, p. 1535-1543Conference paper (Refereed)
  • Syk, Jörgen
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research. Karolinska Inst, Care Sci & Soc, Dept Neurobiol, Stockholm, Sweden;Acad Primary Hlth Care Ctr, Stockholm, Sweden.
    Vinge, Ines
    Lidingo Hosp, Asthma Allergy Lung Dept, Lidingo, Sweden.
    Sorberg, Mikael
    Orion Pharma, Sollentuna, Sweden.
    Vahteristo, Mikko
    Orion Corp, Orion Pharma, Kuopio, Finland.
    Rytila, Paula
    Orion Corp, Orion Pharma, Espoo, Finland.
    A Multicenter, Observational, Prospective Study of the Effectiveness of Switching from Budesonide/Formoterol Turbuhaler® to Budesonide/Formoterol Easyhaler®2019In: Advances in Therapy, ISSN 0741-238X, E-ISSN 1865-8652, Vol. 36, no 7, p. 1756-1769Article in journal (Refereed)
    Abstract [en]

    Introduction

    In real-life practice, asthma remains poorly controlled, with a considerable burden on patients’ quality of life. Budesonide/formoterol (B/F) Easyhaler® has demonstrated similar dose consistency, therapeutic equivalence, and equivalent bronchodilator efficacy to B/F Turbuhaler®, but no real-life comparisons are yet available in patients switching from B/F Turbuhaler® to B/F Easyhaler®.

    Methods

    The primary objective of this real-life, non-interventional, observational study was to show non-inferiority of asthma control when adult patients in Swedish primary care with persistent asthma switched from B/F Turbuhaler® to B/F Easyhaler®. At visit 1, baseline demographic and endpoint data were recorded, and eligible patients switched to B/F Easyhaler®. The study comprised a control visit (visit 2) and a concluding examination (visit 3) after 12 weeks. Asthma control was assessed using the Asthma Control Test (ACT). The mini-Asthma Quality of Life Questionnaire (AQLQ) and lung function test were performed, and participants and investigators answered questionnaires about ease-of-use and teaching.

    Results

    A total of 117 patients were enrolled in the on-treatment population; 81 (64.8%) were female. At visit 3, B/F Easyhaler® demonstrated non-inferiority to B/F Turbuhaler®; the mean difference in change from baseline ACT was statistically significant (18.9 vs. 20.7, respectively; p < 0.0001) and met the non-inferiority criteria of B/F Easyhaler® being greater than − 1.5 points versus the reference product. Asthma was well controlled in 62 (53.0%) patients at baseline, increasing to 83 patients (70.9%) at visit 3. Patients experienced statistically significant improvements in mini-AQLQ score after B/F Easyhaler® treatment and lung function remained stable across the treatment period. B/F Easyhaler® was easy to learn and prepare for use.

    Conclusion

    This real-life, non-interventional, non-inferiority study in adults with persist asthma demonstrates equivalent or better disease control when patients switch from B/F Turbuhaler® to B/F Easyhaler®. A further study with direct comparison between treatments could add to the understanding of inhaler switch.

  • Vessby, Johan
    et al.
    Linnéuniversitetet, Institutionen för teknik, TEK.
    Serrano, Erik
    Linnéuniversitetet, Institutionen för teknik, TEK.
    Enquist, Bertil
    Linnéuniversitetet, Institutionen för teknik, TEK.
    Contact-free measurement and numerical and analytical evaluation of the strain distribution in a wood-FRP lap-joint2010In: Materials and Structures, ISSN 1359-5997, E-ISSN 1871-6873, Vol. 43, no 8, p. 1085-1095Article in journal (Refereed)
    Abstract [en]

    Wood specimens to each of which alaminate of carbon fibre reinforcement polymers(FRP) was glued (creating a lap joint in each case)were loaded to failure. A total of 15 specimens ofthree types differing in the glued length (anchoragelength) of the FRP laminate (50, 150 and 250 mmrespectively) were tested, their strength, stiffness andstrain distribution being evaluated. Synchronizeddigital cameras (charge-coupled devices) used intesting enabled strain fields on surfaces they weredirected at during the loading procedure to bemeasured. These results were also evaluated bothanalytically on the basis of generalized Volkersentheory and numerically by use of the finite elementmethod. The lap joints showed a high level ofstiffness as compared with mechanical joints. A highdegree of accuracy in the evaluation of stiffness wasachieved through the use of the contact-free evaluationsystem. The load-bearing capacity of joints ofthis type was found to be dependent upon theanchorage length in a non-linear fashion. The experimental,analytical and numerical results were shownto be in close agreement with respect to the strengthand the strain distribution obtained.

  • Public defence: 2019-09-20 13:15 Universitetshuset, Uppsala
    Fält, Elisabet
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social medicine/CHAP.
    A cross-service approach to identify mental health problems in 3–5-year-old children using the Strengths and Difficulties Questionnaire2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The Child Healthcare Services (CHS) in Sweden offer regular health check-ups and reach almost all 0–5-year-old children. Although one of the objectives of the CHS is to detect mental health problems, evidence-based methods are not used for this purpose at the Child Health Clinics (CHCs). Therefore, an evidence-based instrument to assess children’s emotional and behavioural problems through parent and teacher reports, the Strengths and Difficulties Questionnaire (SDQ), was introduced, as part of the Children and Parents in Focus trial, run between 2013 and 2017 in Uppsala, Sweden. The overall aim of this thesis was to evaluate the introduction of the procedure, including the facilitation strategies provided to support implementation, and to provide inter-rater correlations and norms for the SDQ in this population.

    Data were collected through individual interviews with nurses, parents and preschool teachers; group interviews with nurses; and a survey performed at the end of the trial to evaluate nurses’ experiences of the SDQ-procedure and the implementation process. In addition, delivery, response rate and population coverage of the questionnaires were calculated. Quantitative data were analysed using descriptive statistics, Pearson correlations and Intraclass Correlation Coefficients (ICC), and qualitative data using Grounded Theory and content analysis.

    Results showed that nurses found it useful for their assessment to have access to preschool teachers’ SDQ-ratings. Parents were also positive to the procedure but had concerns regarding confidentiality of the responses. Preschool teachers were least positive, fearing labelling of children and negative parental reactions. Significant, albeit poor, agreement (ICC) was found between parent and teacher ratings and good agreement between parents’ ratings. Teachers were found to report lower levels of problems compared to parents. Cut-off values differed for age and were somewhat higher for boys (lower for prosocial), suggesting that boys display more behaviour problems. Nurses perceived facilitation strategies used by the research team useful to support implementation and delivered the procedure, essentially, as intended. However, response rate remained lower than expected, around 50%.

    The findings suggest that implementing the SDQ to aid CHC-nurses’ assessment of 3-5-year-olds’ mental health is feasible, but requires further effort in regular services to reach all children.

  • Ekspong, Joakim
    et al.
    Umeå University, Faculty of Science and Technology, Department of Physics.
    Wågberg, Thomas
    Umeå University, Faculty of Science and Technology, Department of Physics.
    Stainless Steel as A Bi-Functional Electrocatalyst – A Top-Down Approach2019In: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 12, no 13, article id 2128Article in journal (Refereed)
    Abstract [en]

    For a hydrogen economy to be viable, clean and economical hydrogen production methods are vital. Electrolysis of water is a promising hydrogen production technique with zero emissions, but suffer from relatively high production costs. In order to make electrolysis of water sustainable, abundant, and efficient materials has to replace expensive and scarce noble metals as electrocatalysts in the reaction cells. Herein, we study activated stainless steel as a bi-functional electrocatalyst for the full water splitting reaction by taking advantage of nickel and iron suppressed within the bulk. The final electrocatalyst consists of a stainless steel mesh with a modified surface of layered NiFe nanosheets. By using a top down approach, the nanosheets stay well anchored to the surface and maintain an excellent electrical connection to the bulk structure. At ambient temperature, the activated stainless steel electrodes produce 10 mA/cm(2) at a cell voltage of 1.78 V and display an onset for water splitting at 1.68 V in 1M KOH, which is close to benchmarking nanosized catalysts. Furthermore, we use a scalable activation method using no externally added electrocatalyst, which could be a practical and cheap alternative to traditionally catalyst-coated electrodes.

  • Rytkönen, Paulina
    et al.
    Södertörn University, School of Social Sciences, Business Studies.
    Larsson Segerlind, Tommy
    Södertörn University, School of Social Sciences, Business Studies.
    Onn, Gustaf
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Tourism Studies.
    Degerstedt, Lars
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Media Technology.
    Kaipainen, Mauri
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Media Technology.
    Facing business challenges with the Stockholm Archipelago as a context: A comparative study of entrepreneurial responses and local development on three islands2019In: Baltic Worlds, ISSN 2000-2955, E-ISSN 2001-7308, Vol. XII, no 2, p. 74-86Article in journal (Refereed)
    Abstract [en]

    By conducting a comparative qualitative and systematic study of the local (island) pre-conditions for creating sustainable socio-economic development through entrepreneurship, here defined as a process of identifying, evaluating, and exploiting entrepreneurial opportunities, this study aims to shed light on entrepreneurial responses to challenges and opportunities on three islands in the Stockholm Archipelago and how context influences these responses.

  • Nordal, Ellen
    et al.
    Univ Hosp North Norway, Dept Pediat, N-9038 Tromso, Norway;UIT Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
    Rypdal, Veronika
    Univ Hosp North Norway, Dept Pediat, N-9038 Tromso, Norway;UIT Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
    Arnstad, Ellen Dalen
    NTNU Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway;Nord Trondelag Hosp Trust, Levanger Hosp, Dept Pediat, Levanger, Norway.
    Aalto, Kristiina
    Univ Helsinki, Childrens Hosp, Helsinki, Finland.
    Berntson, Lillemor
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Ekelund, Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research. Ryhov Cty Hosp, Dept Pediat, Jonkoping, Sweden.
    Fasth, Anders
    Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.
    Glerup, Mia
    Aarhus Univ Hosp, Dept Pediat, Aarhus, Denmark.
    Herlin, Troels
    Aarhus Univ Hosp, Dept Pediat, Aarhus, Denmark.
    Nielsen, Susan
    Copenhagen Univ Hosp, Rigshosp, Dept Pediat, Copenhagen, Denmark.
    Peltoniemi, Suvi
    Univ Helsinki, Childrens Hosp, Helsinki, Finland.
    Zak, Marek
    Copenhagen Univ Hosp, Rigshosp, Dept Pediat, Copenhagen, Denmark.
    Songstad, Nils Thomas
    Univ Hosp North Norway, Dept Pediat, N-9038 Tromso, Norway;UIT Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
    Rygg, Marite
    NTNU Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway;St Olavs Hosp, Dept Pediat, Trondheim, Norway.
    Participation in school and physical education in juvenile idiopathic arthritis in a Nordic long-term cohort study2019In: Pediatric Rheumatology, ISSN 1546-0096, E-ISSN 1546-0096, Vol. 17, article id 44Article in journal (Refereed)
    Abstract [en]

    Background: The aim of the study was to describe school attendance and participation in physical education in school among children with juvenile idiopathic arthritis (JIA).

    Methods: Consecutive cases of JIA from defined geographical areas of Finland, Sweden and Norway with disease onset in 1997 to 2000 were followed for 8 years in a multi-center cohort study, aimed to be as close to population-based as possible. Clinical characteristics and information on school attendance and participation in physical education (PE) were registered.

    Results: Participation in school and in PE was lowest initially and increased during the disease course. Eight years after disease onset 228/274 (83.2%) of the children reported no school absence due to JIA, while 16.8% reported absence during the last 2 months due to JIA. Full participation in PE was reported by 194/242 (80.2%), partly by 16.9%, and none by 2.9%. Lowest participation in PE was found among children with ERA and the undifferentiated categories. Absence in school and PE was associated with higher disease activity measures at the 8-year visit. School absence >1day at baseline predicted use of disease-modifying anti-rheumatic drugs, including biologics (DMARDs) (OR 1.2 (1.1-1.5)), and non-remission off medication (OR 1.4 (1.1-1.7) 8 years after disease onset.

    Conclusion: School absence at baseline predicted adverse long-term outcome. In children and adolescents with JIA participation in school activities is mostly high after 8years of disease. For the minority with low participation, special attention is warranted to promote their full potential of social interaction and improve long-term outcome.

  • Aster, Alexander
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström. Univ Geneva, Dept Phys Chem, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.
    Wang, Shihuai
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Mirmohades, Mohammad
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Esmieu, Charlène
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics. CNRS, LCC, 205 Route Narbonne,BP 44099, F-31077 Toulouse 4, France.
    Berggren, Gustav
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Hammarström, Leif
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström.
    Lomoth, Reiner
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström.
    Metal vs. ligand protonation and the alleged proton-shuttling role of the azadithiolate ligand in catalytic H-2 formation with FeFe hydrogenase model complexes2019In: Chemical Science, ISSN 2041-6520, E-ISSN 2041-6539, Vol. 10, no 21, p. 5582-5588Article in journal (Refereed)
    Abstract [en]

    Electron and proton transfer reactions of diiron complexes [Fe(2)adt(CO)(6)] (1) and [Fe(2)adt(CO)(4)(PMe3)(2)] (4), with the biomimetic azadithiolate (adt) bridging ligand, have been investigated by real-time IR- and UV-vis-spectroscopic observation to elucidate the role of the adt-N as a potential proton shuttle in catalytic H-2 formation. Protonation of the one-electron reduced complex, 1(-), occurs on the adt-N yielding 1H and the same species is obtained by one-electron reduction of 1H(+). The preference for ligand vs. metal protonation in the Fe-2(i,0) state is presumably kinetic but no evidence for tautomerization of 1H to the hydride 1Hy was observed. This shows that the adt ligand does not work as a proton relay in the formation of hydride intermediates in the reduced catalyst. A hydride intermediate 1HHy(+) is formed only by protonation of 1H with stronger acid. Adt protonation results in reduction of the catalyst at much less negative potential, but subsequent protonation of the metal centers is not slowed down, as would be expected according to the decrease in basicity. Thus, the adtH(+) complex retains a high turnover frequency at the lowered overpotential. Instead of proton shuttling, we propose that this gain in catalytic performance compared to the propyldithiolate analogue might be rationalized in terms of lower reorganization energy for hydride formation with bulk acid upon adt protonation.

  • Public defence: 2019-09-13 13:00 Sal B, Kista
    Sollami Delekta, Szymon
    KTH, School of Electrical Engineering and Computer Science (EECS), Electronics.
    Inkjet Printing of Graphene-based Microsupercapacitors for Miniaturized Energy Storage Applications2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Printing technologies are becoming increasingly popular because they enable the large-scale and low-cost production of functional devices with various designs, functions, mechanical properties and materials. Among these technologies, inkjet printing is promising thanks to its direct (mask-free) patterning, non-contact nature, low material waste, resolution down to 10 µm, and compatibility with a broad range of materials and substrates. As a result, inkjet printing has applications in several fields like wearables, opto-electronics, thin-film transistors, displays, photovoltaic devices, and in energy storage. It's in energy storage that the technique shows its full potential by allowing the production of miniaturized devices with a compact form factor, high power density and long cycle life, called microsupercapacitors (MSCs). To this end, graphene has a number of remarkable properties like high electrical conductivity, large surface area, elasticity and transparency, making it a top candidate as an electrode material for MSCs.

    Some key drawbacks limit the use of inkjet printing for the production of graphene-based MSCs. This thesis aims at improving its scalability by producing fully inkjet printed devices, and extending its applications through the integration of inkjet printing with other fabrication techniques.

    MSCs typically rely on the deposition by hand of gel electrolyte that is not printable or by submerging the whole structure into liquid electrolyte. Because of this, so far large-scale production of more than 10 interconnected devices has not been attempted. In this thesis, a printable gel electrolyte ink based on poly(4-styrene sulfonic acid) was developed, allowing the production of large arrays of more than 100 fully inkjet printed devices connected in series and parallel that can be reliably charged up to 12 V. Also, a second electrolyte ink based on nano-graphene oxide, a solid-state material with high ionic conductivity, was formulated to optimize the volumetric performance of these devices. The resulting MSCs were also fully inkjet printed and exhibited an overall device thickness of around 1 µm, yielding a power density of 80 mW cm-3.

    Next, the use of inkjet printing of graphene was explored for the fabrication of transparent MSCs. This application is typically hindered by the so-called coffee-ring effect, which creates dark deposits on the edges of the drying patterns and depletes material from the inside area. In light of this issue, inkjet printing was combined with etching to remove the dark deposits thus leaving uniform and thin films of graphene with vertical sidewalls. The resulting devices showed a transmittance of up to 90%.

    Finally, the issue of the substrate compatibility of inkjet printed graphene was addressed. Although inkjet printing is considered to have broad substrate versatility, it is unreliable on hydrophilic or porous substrates and most inks (including graphene inks) require thermal annealing that damages substrates that are not resistant to heat. Accordingly, a technique based on inkjet printing and wet transfer was developed to reliably deposit graphene-based MSCs on a number of substrates, including flat, 3D, porous, plastics and biological (plants and fruits) with adverse surfaces.

    The contributions of this thesis have the potential to boost the use of inkjet printed MSCs in applications requiring scalability and resolution (e.g. on-chip integration) as well as applications requiring conformability and versatility (e.g. wearable electronics).

  • Herrmann, François R
    et al.
    Geneva Univ Hosp, Dept Rehabil & Geriatr, Div Geriatr, Geneva, Switzerland;Univ Geneva, Geneva, Switzerland.
    Rodriguez, Cristelle
    Univ Geneva, Dept Psychiat, Geneva, Switzerland;Geneva Univ Hosp, Med Direct, Geneva, Switzerland.
    Haller, Sven
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology. CIRO Ctr Imagerie Rive Droite, Geneva, Switzerland;Univ Geneva, Fac Med, Geneva, Switzerland.
    Garibotto, Valentina
    Univ Geneva, Fac Med, Geneva, Switzerland;Geneva Univ Hosp, Div Nucl Med & Mol Imaging, Diagnost Dept, Geneva, Switzerland.
    Montandon, Marie-Louise
    Geneva Univ Hosp, Dept Rehabil & Geriatr, Div Geriatr, Geneva, Switzerland;Univ Geneva, Geneva, Switzerland;Univ Geneva, Dept Psychiat, Geneva, Switzerland.
    Giannakopoulos, Panteleimon
    Univ Geneva, Dept Psychiat, Geneva, Switzerland;Geneva Univ Hosp, Med Direct, Geneva, Switzerland.
    Gray Matter Densities in Limbic Areas and APOE4 Independently Predict Cognitive Decline in Normal Brain Aging2019In: Frontiers in Aging Neuroscience, ISSN 1663-4365, E-ISSN 1663-4365, Vol. 11, article id 157Article in journal (Refereed)
    Abstract [en]

    Cross-sectional magnetic resonance imaging (MRI) studies reported significant associations between gray matter (GM) density changes in various limbic and neocortical areas and worst cognitive performances in elderly controls. Longitudinal studies in this field remain scarce and led to conflicting data. We report a clinico-radiological investigation of 380 cognitively preserved individuals who undergo neuropsychological assessment at baseline and after 18 months. All cases were assessed using a continuous cognitive score taking into account the global evolution of neuropsychological performances. The vast majority of Mini Mental State Examination (MMSE) 29 and 30 cases showed equal or worst performance at follow-up due to a ceiling effect. GM densities, white matter hyperintensities and arterial spin labeling (ASL) values were assessed in the hippocampus, amygdala, mesial temporal and parietal cortex at inclusion using 3 Tesla MRI Scans. Florbetapir positron emission tomography (PET) amyloid was available in a representative subsample of 64 cases. Regional amyloid uptake ratios (SUVr), mean cortical SUVr values (mcSUVr) and corresponding z-scores were calculated. Linear regression models were built to explore the association between the continuous cognitive score and imaging variables. The presence of an APOE-epsilon 4 allele was negatively related to the continuous cognitive score. Among the areas studied, significant associations were found between GM densities in the hippocampus and amygdala but not mesial temporal and parietal areas and continuous cognitive score. Neither ASL values, Fazekas score nor mean and regional PET amyloid load was related to the cognitive score. In multivariate models, the presence of APOE-epsilon 4 allele and GM densities in the hippocampus and amygdala were independently associated with worst cognitive evolution at follow-up. Our data support the idea that early GM damage in the hippocampus and amygdala occur long before the emergence of the very first signs of cognitive failure in brain aging.

  • Memon, Shahbaz
    et al.
    Forschungszentrum Julich, Julich Supercomp Ctr, Leo Brandt Str, D-52428 Julich, Germany;Univ Iceland, Fac Ind Engn Mech Engn & Comp Sci, Reykjavik, Iceland.
    Vallot, Dorothée
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Zwinger, Thomas
    CSC IT Ctr Sci Ltd, Espoo, Finland.
    Åstrom, Jan
    CSC IT Ctr Sci Ltd, Espoo, Finland.
    Neukirchen, Helmut
    Univ Iceland, Fac Ind Engn Mech Engn & Comp Sci, Reykjavik, Iceland.
    Riedel, Morris
    Forschungszentrum Julich, Julich Supercomp Ctr, Leo Brandt Str, D-52428 Julich, Germany;Univ Iceland, Fac Ind Engn Mech Engn & Comp Sci, Reykjavik, Iceland.
    Book, Matthias
    Univ Iceland, Fac Ind Engn Mech Engn & Comp Sci, Reykjavik, Iceland.
    Scientific workflows applied to the coupling of a continuum (Elmer v8.3) and a discrete element (HiDEM v1.0) ice dynamic model2019In: Geoscientific Model Development, ISSN 1991-959X, E-ISSN 1991-9603, Vol. 12, no 7, p. 3001-3015Article in journal (Refereed)
    Abstract [en]

    Scientific computing applications involving complex simulations and data-intensive processing are often composed of multiple tasks forming a workflow of computing jobs. Scientific communities running such applications on computing resources often find it cumbersome to manage and monitor the execution of these tasks and their associated data. These workflow implementations usually add overhead by introducing unnecessary input/output (I/O) for coupling the models and can lead to sub-optimal CPU utilization. Furthermore, running these workflow implementations in different environments requires significant adaptation efforts, which can hinder the reproducibility of the underlying science. High-level scientific workflow management systems (WMS) can be used to automate and simplify complex task structures by providing tooling for the composition and execution of workflows - even across distributed and heterogeneous computing environments. The WMS approach allows users to focus on the underlying high-level workflow and avoid low-level pitfalls that would lead to non-optimal resource usage while still allowing the workflow to remain portable between different computing environments. As a case study, we apply the UNICORE workflow management system to enable the coupling of a glacier flow model and calving model which contain many tasks and dependencies, ranging from pre-processing and data management to repetitive executions in heterogeneous high-performance computing (HPC) resource environments. Using the UNICORE workflow management system, the composition, management, and execution of the glacier modelling workflow becomes easier with respect to usage, monitoring, maintenance, reusability, portability, and reproducibility in different environments and by different user groups. Last but not least, the workflow helps to speed the runs up by reducing model coupling I/O overhead and it optimizes CPU utilization by avoiding idle CPU cores and running the models in a distributed way on the HPC cluster that best fits the characteristics of each model.

  • Sawalha, Sami
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.
    Hedman, Linnea
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Sustainable Health.
    Backman, Helena
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Sustainable Health.
    Stenfors, Nikolai
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.
    Rönmark, Eva
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Sustainable Health.
    Lundback, Bo
    Lindberg, Anne
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.
    The impact of comorbidities on mortality among men and women with COPD: report from the OLIN COPD study2019In: THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, ISSN 1753-4658, Vol. 13, article id 1753466619860058Article in journal (Refereed)
    Abstract [en]

    Background: Comorbidities probably contribute to the increased mortality observed among subjects with chronic obstructive pulmonary disease (COPD), but sex differences in the prognostic impact of comorbidities have rarely been evaluated in population-based studies. The aim of this study was to evaluate the impact of common comorbidities, cardiovascular disease (CVD), diabetes mellitus (DM), and anxiety/depression (A/D), on mortality among men and women with and without airway obstruction in a population-based study. Methods: All subjects with airway obstruction [forced expiratory volume in 1 second (FEV1)/(forced) vital capacity ((F)VC) <0.70, n = 993] were, together with age- and sex-matched referents, identified after examinations of population-based cohorts in 2002-2004. Spirometric groups: normal lung function (NLF) and COPD (post-bronchodilator FEV1/(F)VC <0.70) and additionally, LLN-COPD (FEV1/(F)VC <lower limit of normal). Mortality data was collected until December 2015. Results: In COPD, the prevalence of CVD and DM was higher in men, whereas the prevalence of A/D was higher in women. The cumulative mortality was significantly higher in COPD than NLF, and higher in men than women in both groups. Among women with COPD, CVD and A/D but not DM increased the risk of death independent of age, body mass index, smoking habits, and disease severity, whereas among men DM and A/D but not CVD increased the risk for death. When the LLN criterion was applied, the pattern was similar. Conclusion: There were sex-dependent differences regarding the impact of comorbidities on prognosis in COPD. Even though the prevalence of CVD was higher in men, the impact of CVD on mortality was higher in women, and despite higher prevalence of A/D in women, the impact on mortality was similar in both sexes. The reviews of this paper are available via the supplemental material section.

  • Huang, Jing
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry. KTH Royal Inst Technol, Sch Engn Sci, Dept Appl Phys, Stockholm, Sweden.
    Xu, Bo
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Tian, Lei
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Pati, Palas Baran
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Etman, Ahmed S.
    Stockholm Univ, Dept Mat & Environm Chem MMK, SE-10691 Stockholm, Sweden.
    Sun, Junliang
    Stockholm Univ, Dept Mat & Environm Chem MMK, SE-10691 Stockholm, Sweden.
    Hammarström, Leif
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Tian, Haining
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    A heavy metal-free CuInS2 quantum dot sensitized NiO photocathode with a Re molecular catalyst for photoelectrochemical CO2 reduction2019In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 55, no 55, p. 7918-7921Article in journal (Refereed)
    Abstract [en]

    Heavy metal-free CuInS2 quantum dots (QDs) were employed as a photosensitizer on a NiO photocathode to drive an immobilized molecular Re catalyst for photoelectrochemical CO2 reduction for the first time. A photocurrent of 25 mu A cm(-2) at -0.87 V vs. NHE was obtained, providing a faradaic efficiency of 32% for CO production.