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  • Public defence: 2017-03-17 10:00 Kollegiesalen, Stockholm
    Raj, Akanksha
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Surface and Corrosion Science.
    Synergies in Biolubrication2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The objective of this thesis was to advance understanding in the field of biolubrication, finding inspiration from the human synovial joints. This was addressed by investigating the association of key biolubricants and the resulting lubrication performance. Techniques employed during the course of this work were Atomic force microscopy (AFM), Quartz crystal microbalance with dissipation monitoring (QCM-D), X-ray reflectivity (XRR).

    Key synovial fluid and cartilage components like dipalmitoylphosphatidylcholine (DPPC), hyaluronan (HA), lubricin, and cartilage oligomeric matrix protein (COMP) have been used in the investigations. Focus was towards two lubrication couples; DPPC-hyaluronan and COMP-lubricin. DPPC-hyaluronan mixtures were probed on hydrophilic silica surfaces and COMP-lubricin association structures were explored on weakly hydrophobic poly (methyl methacrylate) (PMMA) surfaces.

    Investigations of the COMP-lubricin pair revealed that individually these components are unable to reach desired lubrication. However in combination, COMP facilitates firm attachment of lubricin to the PMMA surface in a favourable confirmation that imparts low friction coefficient.

    DPPC and hyaluronan combined impart lubrication advantage over lone DPPC bilayers. Hyaluronan provides a reservoir of DPPC on the surface and consequently self-healing ability.

    Other factors like temperature, presence of calcium ions, molecular weight of hyaluronan, and pressure were also explored. DPPC bilayers at higher temperature had higher load bearing capacity. Association between DPPC Langmuir layers and hyaluronan was enhanced in the presence of calcium ions, and lower molecular weight hyaluronan had a stronger tendency to bind to DPPC. At high pressures, DPPC-hyaluronan layers were more stable compared to lone DPPC bilayers.

  • Public defence: 2017-03-17 09:30 D2, Stockholm
    Brown, Nils W. O.
    KTH, School of Architecture and the Built Environment (ABE), Urban Planning and Environment, Environmental Strategies (moved 20130630).
    Managing high environmental performance?: Applying life cycle approaches and environmental certification tools in the building and real estate sectors2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The main aim of this thesis is  to demonstrate and critically assess life cycle approaches’ and environmental certification (EC) tools’ potential for supporting decisions for improved environmental performance in the building and real estate sectors.

    Using life cycle approaches, the thesis shows that for new build and renovation cases aiming for low operational energy use that embodied global warming potential (GWP) due to material production can constitute a large portion of a building’s lifetime GWP. Therefore life cycle based information about materials’ embodied GWP needs to be made available to and utilized by design process decision makers.

    It was also shown that applying the Swedish EC tool Miljöbyggnad was useful in highlighting potential positive and negative changes in indoor environmental quality arising from renovation packages aiming at significant operational energy use reduction in existing multifamily buildings. However such renovation packages are not profitable from a property owner perspective. Miljöbyggnad may be useful when designing policy instruments to overcome this.   

    The thesis also showed that EC and related environmental enhancements contribute to achieving property owners’ and tenants’ overall strategic objectives for value creation. For property owners this arises for example through lower energy costs and attracting desirable tenants. For tenants, value creation arises as support for internal and external environmental communication.

    For the further development of life cycle approaches’ and EC tools’ application to buildings and real estate it is important to consider how they can be adapted to consider ‘distance to sustainable’ targets referencing for instance the planetary boundaries approach. It is also interesting to investigate how valuation of buildings and real estate may be performed in a way that expands from the current narrow focus on the economic perspective to also include environmental and social perspectives.

  • Asprem, Egil
    Stockholm University, Faculty of Humanities, Department of Ethnology, History of Religions and Gender Studies.
    Explaining the Esoteric Imagination: Towards a Theory of Kataphatic Practice2017In: Aries: Journal for the Study of Western Esotericism, ISSN 1567-9896, E-ISSN 1570-0593, Vol. 17, no 1, 17-50 p.Article in journal (Refereed)
    Abstract [en]

    The imagination is central to esoteric practices, but so far scholars have shown littleinterest in exploring cognitive theories of how the imagination works. The onlyexception is Tanya Luhrmann’s interpretive drift theory and related research on mentalimagery cultivation, which has been used to explain the subjective persuasiveness ofmodern ritual magic. This article draws on recent work in the neuroscience of perceptionin order to develop a general theory of kataphatic (that is, imagery based) practicethat goes beyond the interpretive drift theory. Mental imagery is intimately linked withperception. Drawing on “predictive coding” theory, the article argues that kataphaticpractices exploit the probabilistic, expectation-based way that the brain processes sensoryinformation and creates models (perceptions) of the world. This view throws lighton a wide range of features of kataphatic practices, from their contemplative and cognitiveaspects, to their social organization and demographic make-up, to their pageantryand material culture. By connecting readily observable features of kataphatic practiceto specific neurocognitive mechanisms related to perceptual learning and cognitiveprocessing of mental imagery, the predictive coding paradigm also creates opportunitiesfor combining historical research with experimental approaches in the study ofreligion. I illustrate how this framework may enrich the study of Western esotericismin particular by applying it to the paradigmatic case of “astral travel” as it has developedfrom the Golden Dawn tradition of ritual magic, especially in the work of AleisterCrowley.

  • Parra Rosales, Luz Paula
    Stockholm University, Faculty of Humanities, Department of Romance Studies and Classics, Institute of Latin American Studies.
    Estrategía de Mediación: Familiar, Escolar y Comunicación.: Metodología de Acción para los programas de Prevención Social de Estados y Municipios.2014Other (Other (popular science, discussion, etc.))
    Abstract [es]

    El objetivo de esta metodología de acción es servir como una herramienta de prevención social de la violencia y la delincuencia, contribuyendo a la transformación positiva de los conflictos, a la convivencia ciudadana mediante la formación y la capacitación en mediación y a la generación de espacios de diálogo par ala construcción de acuerdos.

    La presente metodología está integrada por diferentes apartados. Al inicio se expone el marco conceptual y su vínculo con el Programa Nacional de Prevención Social de la Violencia y la Delincuencia. En el siguiente apartado, se señalan los factores de riesgo relacionados con el manejo inadecuado de los conflictos sociales y comunitarios en distintos ámbitos y sectores. Posteriormente, se presentan de manera general las recomendaciones estratégicas de capacitación en mediación y los temas necesarios para trabajar en torno a la mediación familiar, escolar y comunitaria de forma particular. En seguida, se detallan los requisitos necesarios para cre4ar espacios para el diálogo y la construcción de acuerdos. Finalmente, se incluyen los indicadores necesarios para alcanzar los objetivos propuestos en esta metodología, así como la bibliografía y las fuentes relacionadas con las mejores prácticas a nivel nacional e internacional.

  • Asprem, Egil
    Stockholm University, Faculty of Humanities, Department of Ethnology, History of Religions and Gender Studies.
    What Cognitive Science Offers the Study of Esotericism2017In: Aries: Journal for the Study of Western Esotericism, ISSN 1567-9896, Vol. 17, no 1, 1-15 p.Article in journal (Other academic)
  • Alger, Susanne
    et al.
    Umeå University, Faculty of Social Sciences, Department of applied educational science, Departement of Educational Measurement.
    Eklöf, Hanna
    Umeå University, Faculty of Social Sciences, Department of applied educational science, Departement of Educational Measurement.
    Jämförelser mellan provorter: en studie av körprov för behörighet B2016Report (Other academic)
    Abstract [en]

    There are more than 130 places in Sweden where driving tests can be carried out, with their own particular traffic environments, examiners and test-takers. The test-takers' ages and their preferred method of registering for the test vary between places. In some places only a few tests are carried out and in some a large number of tests. In some places certain aspects of the traffic environment are absent, like motorways, railway crossings or roundabouts. The intensity of traffic also varies between different locations. In short, there are many aspects that can vary between individual tests. In this report various ways of presenting such differences and some ways of categorizing places are explored.

    Does this have consequences for results? It is difficult to analyse as several variables probably interact and are hard to untangle and due to the nature of the data. The result is binary – pass/fail – which limits what analyses can be made – and there are many categories in the variables place and examiner. In order to achieve fewer categories some can be collapsed into fewer and larger categories. The question is then how many categories and what criteria should be used to form them. When analyses are made we can see that the content of tests differ both within a particular location and between different places. It is, however, unclear if the same or different skills and abilities are measured in different places, but nevertheless not as simple as to claim that it is "easier" to obtain a licence in certain places than others based on simple comparisons of success rates. Test-takers' age and method of registration for the test, aspects that we know are connected to the percentage of passed tests, also differ between places.

  • Babchishin, K. M.
    et al.
    Univ Ottawa, Royals Inst Mental Hlth Res, Ottawa, ON, Canada.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Seto, M. C.
    Univ Ottawa, Royals Inst Mental Hlth Res, Ottawa, ON, Canada..
    Sariaslan, A.
    Univ Oxford, Dept Psychiat, Oxford, England..
    Lichtenstein, P.
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Fazel, S.
    Univ Oxford, Dept Psychiat, Oxford, England..
    Långström, Niklas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Parental and perinatal risk factors for sexual offending in men: a nationwide case-control study2017In: Psychological Medicine, ISSN 0033-2917, E-ISSN 1469-8978, Vol. 47, no 2, 305-315 p.Article in journal (Refereed)
    Abstract [en]

    Background. Prior studies suggest parental and perinatal risk factors are associated with later offending. It remains uncertain, however, if such risk factors are similarly related to sexual offending. Method. We linked socio-demographic, family relations, and perinatal (obtained at birth) data from the nationwide Swedish registers from 1973 to 2009 with information on criminal convictions of cases and control subjects. Male sex offenders (n = 13 773) were matched 1: 5 on birth year and county of birth in Sweden to male controls without sexual or non-sexual violent convictions. To examine risk-factor specificity for sexual offending, we also compared male violent, non-sexual offenders (n = 135 953) to controls without sexual or non-sexual violent convictions. Predictors included parental (young maternal or paternal age at son's birth, educational attainment, violent crime, psychiatric disorder, substance misuse, suicide attempt) and perinatal (number of older brothers, low Apgar score, low birth weight, being small for gestational age, congenital malformations, small head size) variables. Results. Conditional logistic regression models found consistent patterns of statistically significant, small to moderate independent associations of parental risk factors with sons' sexual offending and non-sexual violent offending. For perinatal risk factors, patterns varied more; small for gestational age and small head size exhibited similar risk effects for both offence types whereas a higher number of older biological brothers and any congenital malformation were small, independent risk factors only for non-sexual violence. Conclusions. This nationwide study suggests substantial commonalities in parental and perinatal risk factors for the onset of sexual and non-sexual violent offending.

  • Anderberg, Sabina
    Stockholm University, University Library.
    Hantering av forskningsdata vid Stockholms universitet: Förslag till strategi och struktur2016Report (Other academic)
    Abstract [sv]

    Stockholms universitet (SU) har som myndighet ansvar för att lagra, tillgängliggöra och bevara forskningsdata som produceras vid lärosätet. För att kunna ta detta ansvar fullt ut behövs en gemensam, samordnad strategi och struktur. Under hösten 2016 har en projektgrupp haft i uppdrag att utforma och lämna förslag till en för Stockholms universitet gemensam strategi och struktur för hur forskningsdata kan hanteras, tillgängliggöras och lagras kort- och långsiktigt. Projektet har pågått under tidsperioden september till december 2016 och samordnats av universitetsbiblioteket. Projektgruppen har bestått av representanter från Universitetsförvaltningen (arkiv, bibliotek, forskarstöd, IT, planerings- och ledningsstöd) och forskarrepresentanter från Humanvetenskapliga och Naturvetenskapliga området.

    Syftet med projektet har varit att övergripande identifiera behovet av forskningsstödjande tjänster, förvaltningens resursbehov för att kunna tillhandahålla detta, och skapa en förbättrad beredskap vid lärosätet inför EU-deklarerade och troliga kommande nationella direktiv och riktlinjer för öppen tillgång till forskningsdata. Målsättningen har varit att undersöka vilket stöd och vilka tjänster forskarna efterfrågar, hur behoven inom de olika disciplinerna ser ut, hur förvaltningen kan förbättra samverkan, samordning och utveckling av de forskningsstödjande tjänsterna, vilka riktlinjer, policys o.dyl. som finns och vilka som behöver utvecklas för hantering, lagring, tillgängliggörande och bevarande av forskningsdata. Arbetet har utgått från att; samordna, samverka och säkerställa förbättrade möjligheter och verksamhet för utveckling av forskningsstödjande tjänster för forskningsdata. Rapporten är uppdelad i tre områden: strategi, struktur och systemstöd. Inom varje område beskrivs kort förutsättningar, behov och förslag. Rapporten innehåller en sammanställning av övergripande förslag på kommande åtgärder och uppdrag för strategi, policys och riktlinjer, rättsutredning, arbetsorganisation, handledningsstöd, informations- och kommunikationsinsatser samt systemstöd för lagring, tillgängliggörande och bevarande. Rapporten är närmast att betrakta som en förstudie inför kommande specifika uppdrag inom respektive område.

  • Public defence: 2017-03-03 10:00 F3, Stockholm
    Zmijewski, Nicholas
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Hydraulic Engineering.
    Effects of Watershed Dynamics on Water Reservoir Operation Planning: Considering the Dynamic Effects of Streamflow in Hydropower Operation2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Water reservoirs are used to regulate river discharge for a variety of reasons, such as flood mitigation, water availability for irrigation, municipal consumption and power production purposes. Recent efforts to increase the amount of renewable power production have seen an increase in intermittent climate-variable power production due to wind and solar power production. The additional variable energy production has increased the need for regulating the capacity of the electrical system, to which hydropower production is a significant contributor. The hydraulic impact on the time lags of flows between production stations have often largely been ignored in optimization planning models in favor of computational efficiency and simplicity. In this thesis, the hydrodynamics in the stream network connecting managed reservoirs were described using the kinematic-diffusive wave (KD) equation, which was implemented in optimization schemes to illustrate the effects of wave diffusion in flow stretches on the resulting production schedule. The effect of wave diffusion within a watershed on the variance of the discharge hydrograph within a river network was also analyzed using a spectral approach, illustrating that wave diffusion increases the variance of the hydrograph while the regulation of reservoirs generally increases the variance of the hydrograph over primarily short periods. Although stream hydrodynamics can increase the potential regulation capacity, the total capacity for power regulation in the Swedish reservoir system also depends significantly on the variability in climatic variables. Alternative formulations of the environmental objectives, which are often imposed as hard constraints on discharge, were further examined. The trade-off between the objectives of hydropower production and improvement of water quality in downstream areas was examined to potentially improve the ecological and aquatic environments and the regulation capacity of the network of reservoirs.

  • Forsman, Åsa
    Swedish National Road and Transport Research Institute, Traffic and road users, Traffic safety, society and road-user.
    Förstudie om antal alkoholutandningsprov i trafiken2016Report (Other academic)
    Abstract [sv]

    Hur ska polisens övervakning av alkoholrattfylleri bedrivas? Det är en fråga som har aktualiserats den senaste tiden dels på grund av polisens nya organisation som introducerades 1 januari 2015 och dels på grund av att antal alkoholutandningsprov som utförs varje år har minskat med drygt 50 procent mellan år 2010 och 2015. Frågan är komplex och behöver belysas från olika håll. I den här PM:et belyses frågan om antal alkoholutandningsprov och dess betydelse för rattfylleriets omfattning. PM:et ska ses som ett underlag för fortsatta diskussioner om polisens övervakning men även om vilken ytterligare forskning som behövs inom området. Underlaget baseras på tre delar: (i) en jämförelse mellan antal utandningsprov som görs i Sverige och antalet i andra länder, (ii) en jämförelse av subjektiv och faktisk upptäcktsrisk baserat på data från ESRA–projektet (European Survey of Road Users’ Safety Attitudes) och (iii) en sammanställning av aktuell forskning på området.

    Uppgifter om antal utandningsprov saknas i många länder men en jämförelse har kunnat göras mellan Sverige och 13 andra europeiska länder. Resultaten visar att Sverige var det land bland dessa som år 2010 utförde flest prov per invånare. År 2015 var det sex länder som utförde fler prov per invånare än vad Sverige gjorde: Österrike, Estland, Finland, Frankrike, Polen och Slovenien. En jämförelse med Australien visar också att flera av dess delstater utför betydligt fler utandningsprov per körkortsinnehavare än vad man gör i Sverige.

    Litteraturgenomgången visar att om man ökar antal prov leder det till en högre subjektiv upptäcktsrisk vilket i sin tur leder till en högre allmänpreventiv effekt. Det behövs dock mer forskning om vilken nivå på övervakningens omfattning som ger bäst avvägning mellan polisens resurser och antal rattfylleribrott.

    Det är inte bara polisens övervakning som har betydelse för antal rattfylleribrott. Andra faktorer som till exempel sociala normer är också viktiga. Resultat från ESRA-studien visar bland annat att det är väldigt få som kör rattfulla i Sverige även om den subjektiva upptäcktsrisken är ganska låg jämfört med flera av de andra länderna. En slutsats av det är att det behövs mer forskning om de specifika förhållanden som gäller i Sverige. Senast det gjordes någon större studie om rattfylleriövervakningens effekter i Sverige var i början på 1990-talet. Idag sker en stor del av forskningen i USA och Australien och dess grannländer och det är svårt att direkt översätta dessa resultat till svenska förhållanden.

  • Persson, Fredrik
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Hållbar Samhällsbyggnad.
    Andersson, Jan-Erik
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Hållbar Samhällsbyggnad.
    Automatisk övervakning och uppföljning i torkprocessen2016Report (Other academic)
    Abstract [en]

    The goal of the project was to develop technology that makes it possible to automatically monitor and control the drying process and thus meet the target moisture content with higher precision.

    Weighing of the green wood was seen as a feasible and cost-effective method to get information about the green wood density and moisture content. The hypothesis was that the variations in dry density of pine and spruce are low enough to give a good enough estimate of green moisture content when weighing the timber before drying. A scale was installed at Kåge sawmill in the green sorter between the sink bins and the sticker stacker. All wood that passed the scale was weighted automatically and the three regular check-ups of the scale showed that it had an accuracy of just under 0,9% in relation to the reference weight. This gives an error of 1,8 – 2 % of the calculated moisture content depending on the variation of density of the wood

    The density of green wood, dry density and green moisture content was followed for four products between March and November 2013, one thin and one thick for both spruce and pine. The results from the tests showed variations of the dry density is subordinate to the green moisture content. The largest variation in green moisture content was found for 32 x 125 mm pine where it varied between 64 and 82 %. Spruce with the dimensions 63x150 mm was the only dimension that did not have any variation in green moisture content.

    Measurements indicate that it is possible to achieve the set goals: to be able to predict the green moisture content by about ± 5% points, while also adding variations in dry density, scale uncertainty and fluctuating green dimensions.

    Key words: Packet weight, industrial sawmill, wood drying

  • Simeon, Saw
    et al.
    Mahidol Univ, Fac Med Technol, Ctr Data Min & Biomed Informat, Bangkok 10700, Thailand..
    Shoombuatong, Watshara
    Mahidol Univ, Fac Med Technol, Ctr Data Min & Biomed Informat, Bangkok 10700, Thailand..
    Anuwongcharoen, Nuttapat
    Mahidol Univ, Fac Med Technol, Ctr Data Min & Biomed Informat, Bangkok 10700, Thailand..
    Preeyanon, Likit
    Mahidol Univ, Fac Med Technol, Dept Community Med Technol, Bangkok 10700, Thailand..
    Prachayasittikul, Virapong
    Mahidol Univ, Fac Med Technol, Dept Community Med Technol, Bangkok 10700, Thailand..
    Wikberg, Jarl E. S.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Nantasenamat, Chanin
    Mahidol Univ, Fac Med Technol, Ctr Data Min & Biomed Informat, Bangkok 10700, Thailand..
    osFP: a web server for predicting the oligomeric states of fluorescent proteins2016In: Journal of Cheminformatics, ISSN 1758-2946, E-ISSN 1758-2946, Vol. 8, 72Article in journal (Refereed)
    Abstract [en]

    Background: Currently, monomeric fluorescent proteins (FP) are ideal markers for protein tagging. The prediction of oligomeric states is helpful for enhancing live biomedical imaging. Computational prediction of FP oligomeric states can accelerate the effort of protein engineering efforts of creating monomeric FPs. To the best of our knowledge, this study represents the first computational model for predicting and analyzing FP oligomerization directly from the amino acid sequence. Results: After data curation, an exhaustive data set consisting of 397 non-redundant FP oligomeric states was compiled from the literature. Results from benchmarking of the protein descriptors revealed that the model built with amino acid composition descriptors was the top performing model with accuracy, sensitivity and specificity in excess of 80% and MCC greater than 0.6 for all three data subsets (e.g. training, tenfold cross-validation and external sets). The model provided insights on the important residues governing the oligomerization of FP. To maximize the benefit of the generated predictive model, it was implemented as a web server under the R programming environment. Conclusion: osFP affords a user-friendly interface that can be used to predict the oligomeric state of FP using the protein sequence. The advantage of osFP is that it is platform-independent meaning that it can be accessed via a web browser on any operating system and device. osFP is freely accessible at http://codes.bio/osfp/ while the source code and data set is provided on GitHub at https://github.com/chaninn/osFP/.

  • Johnson, Kyle D.
    KTH, School of Engineering Sciences (SCI), Physics, Reactor Physics.
    High Performance Fuels for Water-Cooled Reactor Systems2016Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Investigation of nitride fuels and their properties has, for decades, been propelled on the basis of their desirable high metal densities and high thermal conductivities, both of which oer intrinsic advantages to performance, economy, and safety in fast and light water reactor systems. In this time several key obstacles have been identied as impeding the implementation of these fuels for commercial applications; namely chemical interactions with air and steam, the noted diculty in sintering of the material, and the high costs associated with the enrichment of 15N. The combination of these limitations, historically, led to the well founded conclusion that the most appropriate use of nitride fuels was in the fast reactor fuel cycle, where the cost burdens associated with them is substantially less. Indeed, it is within this context that the vast majority of work on nitrides has been and continues to be done.

    Nevertheless, following the 2011 Fukushima-Daiichi nuclear accident, a concerted governmental-industrial eort was embarked upon to explore the alternatives of so-called \accident tolerant" and \high performance" fuels. These fuels would, at the same time, improve the response of the fuel-clad system to severe accidents and improve the economy of operation for light water reactor systems. Among the various candidates proposed are uranium nitride, uranium silicide, and a third \uranium nitride-silicide" composite featuring a mixture of the former.

    In this thesis a method has been established for the synthesis, fabrication, and characterization of high purity uranium nitride, and uranium nitride-silicide composites, prepared by the spark plasma sintering (SPS) technique. A specic result has been to isolate the impact of the processing parameters on the microstructure of representative fuel pellets, essentially permitting any conceivable microstructure of interest to be fabricated. This has enabled the development of a highly reproducible technique for the production of pellets with microstructures tailored towards any desired porosity between 88-99.9%TD, any grain size between 6-24 μm, and, in the case of  the uranium nitride-silicide composite, a silicide-coated UN matrix. This has permitted the evaluation of these microstructural characteristics on the performance of these materials, specically with respect to their role as accident tolerant fuels. This has generated results which have tightly coupled nitride performance with pellet microstructure, with important implications for the use of nitrides in water-cooled reactors.

  • Domert, Jakob
    et al.
    Linkoping Univ, Dept Clin Pathol, Linkoping, Sweden.;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden..
    Sackmann, Christopher
    Linkoping Univ, Dept Clin Pathol, Linkoping, Sweden.;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden..
    Severinsson, Emelie
    Linkoping Univ, Dept Clin Pathol, Linkoping, Sweden.;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden..
    Agholme, Lotta
    Linkoping Univ, Dept Clin Pathol, Linkoping, Sweden.;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden..
    Bergström, Joakim
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Ingelsson, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Hallbeck, Martin
    Linkoping Univ, Dept Clin Pathol, Linkoping, Sweden.;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden..
    Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes2016In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 12, e0168700Article in journal (Refereed)
    Abstract [en]

    Parkinson's disease and other alpha-synucleinopathies are progressive neurodegenerative diseases characterized by aggregates of misfolded alpha-synuclein spreading throughout the brain. Recent evidence suggests that the pathological progression is likely due to neuron-to-neuron transfer of these aggregates between neuroanatomically connected areas of the brain. As the impact of this pathological spreading mechanism is currently debated, we aimed to investigate the transfer and subcellular location of alpha-synuclein species in a novel 3D co-culture human cell model based on highly differentiated SH-SY5Y cells. Fluorescently-labeled monomeric, oligomeric and fibrillar species of alpha-synuclein were introduced into a donor cell population and co-cultured with an EGFP-expressing acceptor-cell population of differentiated neuron-like cells. Subsequent transfer and colocalization of the different species were determined with confocal microscopy. We could confirm cell-to-cell transfer of all three alpha-synuclein species investigated. Interestingly the level of transferred oligomers and fibrils and oligomers were significantly higher than monomers, which could affect the probability of seeding and pathology in the recipient cells. Most alpha-synuclein colocalized with the lysosomal/endosomal system, both pre- and postsynaptically, suggesting its importance in the processing and spreading of alpha-synuclein.

  • Public defence: 2017-03-03 10:00 Hamberg, Uppsala
    Muhamad, Harbe
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Geophysics.
    Geophysical studies in the western part of the Siljan Ring Impact Crater2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis utilizes several geophysical methods to study the Siljan Ring impact structure, focusing on the western part of the structure. This thesis, and the three papers upon which it is based, reports on attempts to delineate the Paleozoic rocks at depth within the annular ring graben and characterize their structure. In addition, the nature of the basement, which underlies these sedimentary rocks is investigated.

    Papers I and III focus on analysis of the down-hole logging and borehole core data. As well as the acquisition, processing and interpretation of 2D high-resolution reflection seismic data from the Mora area. The borehole log responses were compared with the core lithology from the Mora 001 borehole and information from two other cores (Mora VM 2 and Mora MV 3) in order to interpret the logs. The logs reveal significant changes in the lithology between boreholes, indicating a very high level of structural complexity, which is attributed to impact tectonics. In addition, the log data revealed a high sonic velocity contrast between the Silurian and Ordovician successions and a higher apparent temperature gradient than in the northern part of the structure. The interpretation of the high-resolution 2D seismic data suggest that the Mora area has been significantly affected by the impact. Several potential faults were identified in the area and interpreted to be post depositional and related to the impact. In paper II, a 2D seismic profile from the Orsa area (12 km) located in the northwestern part of the Siljan Ring was re-processed. To compliment this seismic line, first break traveltime tomography results, vintage seismic OPAB profiles, new and pre-existing gravity data, aeromagnetic data and the bedrock geological map were used to present a geological model along the Orsa profile. Reprocessing of the seismic data resulted in improved stacked and migrated sections and better imaging of the top of the crystalline basement than the original processing. Integrated interpretation of the seismic profiles suggests that the area has been significantly affected by faulting and that the depth to the basement varies greatly along the different profiles.

  • Public defence: 2017-03-03 10:15 Geijersalen, Uppsala
    Ekoluoma, Mari-Elina
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Cultural Anthropology and Ethnology.
    Everyday Life in a Philippine Sex Tourism Town2017Doctoral thesis, monograph (Other academic)
    Abstract [en]

    Sabang used to be a small, marginalized Philippine fishing village that in the span of three decades became a well-known international sex tourism site. This thesis deals with the implications of tourism (including sex tourism) and how it has become embedded in the daily life in today’s Sabang. The thesis highlights the local populations’ diverse reactions to the various changes associated with tourism growth, in particular how various symbolic, moral, and spatial boundaries are constructed and maintained.

    The ethnographic material examined in this thesis builds on several periods of fieldwork, in total 18 months, that were carried out between 2003 and 2015. Analytical tools found in tourism anthropology and in particular the branch of postcolonial tourism studies has guided the discussion and analysis of the socio-cultural effects of becoming a tourism town.

    This thesis argues that complex networks of boundaries are significant in maintaining a sense of order and social cohesion in times of change. Notions of cultural differences are expressed through the narratives and behaviors of the various inhabitants, and contribute to the maintaining of boundaries within and between groups. From the beginning of tourism growth commercial sex has been central and has become a significant factor in the tourism economy. While residents acknowledge their dependency on the go-go bars, the business of the night is framed so as not to defeat the inhabitants’ struggles to maintain local community’s sense of morality, or at least to set up boundaries between the outsiders’ immorality and insiders’ morality. Tourism has also offered opportunities to challenge conventional social hierarchies and local seats of power, and there are also recurrent discussions about who has the right to control resources and who can claim entitlement to a place now shared by people from all over the world.  

  • Shekhar, Gurmeet
    et al.
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Mining and Geotechnical Engineering.
    Gustafson, Anna
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Mining and Geotechnical Engineering.
    Schunnesson, Håkan
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Mining and Geotechnical Engineering.
    Loading Procedure and Draw Control in LKAB’s Sublevel Caving Mines: Baseline Mapping Report2017Report (Other academic)
    Abstract [en]

    Sublevel caving (SLC) is an underground mass mining method used to extract iron ore from the Kiirunavaara and Malmberget mines. Although both mines use SLC as the mining method, their implementation varies in terms of mine design, ring design and draw control strategy. The Kiirunavaara mine has a continuous and massive ore deposit which allows a standard mine design layout, while the Malmberget mine has scattered ore bodies with varying mine design parameters. The two mines also employ different opening techniques for production drifts.

    Luossavaara-Kiirunavaara AB (LKAB) uses different information systems to run these highly mechanized mines. The information generated by the various systems is transferred between the different unit operations and is used to optimize the mining process. The mines use GIRON to create, store and display different information related to the mining operation. Information on all unit operations is stored in a number of databases inside GIRON. The two loading related information systems which support the loading operation are the Wireless Loader Information System (WOLIS) and the Loadrite system. The Loadrite system measures the bucket weights being loaded by the Load Haul Dump (LHD) machines at the draw point. This information, along with information on planned ring tonnage etc., is displayed to the LHD operator inside the LHD machine using WOLIS. WOLIS provides online data on the ring performance such as grades, tonnage extracted etc. to the LHD operators and the production team.

    In SLC, the different aspects of loading at the draw point include loading procedures, loading issues, loading criteria and loading constraints. Loading procedures include the practices and precautions taken during loading at the draw point. Loading issues include events observed at both mines, such as brow failure, ring freeze, hang-ups etc. Although most loading issues are handled in a similar manner, hang-up handling techniques are different at the Kiirunavaara and Malmberget mines. Loading criteria and constraints along with the nature of material flow collectively provide a complete understanding of the draw control strategy. Loading criteria comprise a set of rules or guidelines for loading and closing a draw point. LKAB uses WOLIS to enforce the loading criteria for its SLC operations. Loading constraints include production constraints, grade control and mining constraints which must be followed for a safe and sustainable mining operation.

    A baseline analysis of the draw control and loading operations at the Kiirunavaara and Malmberget mines is summarized in this report using information collected through internal documents, meetings, e-mails and manuals.  

  • Public defence: 2017-03-06 13:15 Uppsala
    Bai, Wensong
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies.
    The Best of Both Worlds: The Effects of Knowledge and Network Relationships on Performance of Returnee Entrepreneurial Firms2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In an increasingly globalized business world, international human mobility and its association with entrepreneurship presents attractive opportunities for business research. One increasingly important phenomenon in the field is returnee entrepreneurship, which is the reverse flow of migrants who acquired skills in developed countries back to their emerging-market home countries. In this way, knowledge from developed countries transfers back to, and fills technological and entrepreneurial gaps in, emerging countries. This thesis aims to explain returnee entrepreneurship by examining what factors differentiate innovation, internationalization and business performance of returnee entrepreneurial firms.

    The empirical investigation uses a mixed method approach comprising a qualitative single case study and four quantitative studies of a recent sample of 200 Chinese returnee entrepreneurial firms, and focusses on factors such as knowledge and network relationships, which are two advantages that returnee entrepreneurial firms are thought to have. By distinguishing among types of knowledge from various sources, and network relationships from both international and domestic origins, the findings show that international opportunity knowledge and domestic business relationships influence the innovation performance of returnee entrepreneurial firms. The structural characteristics of the international network of a returnee entrepreneurial firm are related to that firm’s international networking capability, which in turn influence its opportunity-driven internationalization. Additionally, the international experiential knowledge of returnee entrepreneurs nurtures their firms’ international market knowledge, and these experiences also indirectly affect firm internationalization by being transmitted through that market knowledge. Finally, international networking capability and innovation performance positively influence the business performance of returnee entrepreneurial firms, whereas the international business knowledge has a negative impact on business performance.

    The thesis challenges the enthusiastic view of returnee entrepreneurial firms by refining the heterogeneity of both the returnee entrepreneurs themselves, and the performance variances of their ventures. Empirically, this thesis suggests a combination of knowledge and resources from both ‘worlds’ that can best benefit the performance of a returnee entrepreneurial firm. This thesis also contributes to theory by providing new insights into the combined effect of (1) an individual entrepreneur’s international experience, and (2) a new venture’s knowledge base and capabilities; furthermore it also describes what that combined effect will be on the new venture’s performance.

  • Public defence: 2017-03-03 10:15 Hörsal 1, Ekonomikum, Uppsala
    Pasay, Sarah Linden
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economic History.
    Stable Media in the Age of Revolutions: Depictions of Economic Matters in British and Swedish State Newspapers, 1770–18202017Doctoral thesis, monograph (Other academic)
    Abstract [en]

    The dissertation examines how economic matters were depicted between 1770 and 1820 in two European kingdoms. Britain and Sweden are studied during this Age of Revolutions from the state’s perspective; state-managed newspapers are examined, one from Britain, the London Gazette, and two from Sweden, Stockholms Post-Tidningar and Inrikes Tidningar. These were stable types of media that transformed slowly alongside the changing popular press. State-managed newspapers were produced both to inform and manage the loyalty of populations. Aside from the continued development of the centralized state, this was also the time when Enlightenment ideals were spreading, the public sphere was transforming, notions of the nation and nationalism were developing, and communication strategies were changing; these concepts are the basis for the model of the development of modernity used in this study.

    Economic matters are seen as existing in a value-realm model that gradually disintegrated over time, expressing the birth of the modern world. This model included political, social-cultural, and technological values, in addition to economic matters. This disintegration involved a sense of uniformity. In both Britain and Sweden, economic objects, practices, ideas, and discourses received similar treatments over time. This process was, however, non-linear and not complete by the dawn of industrial transformation.  

    The first two chapters discuss the theory and methodological approaches. The form, order, and content of the newspapers are analyzed to show how economic matters became separate or unembedded to varying degrees over a fifty-year time span. British and Swedish descriptions are compared, as well as how the other state was portrayed in the opposing newspapers. These observations are described in three empirical chapters, relating events and analyses from 1770 to 1775, 1790 to 1795, and 1815 to 1820.

    The results of this dissertation show how early modern economic matters can be viewed beyond quantitative contents as an expression of becoming modern, offering complimentary context. Advances in thinking about data generated modern numerical indicators, also reflected by form and order qualities. The unembeddedness of economic matters was an ongoing and non-linear process that was expressed by increased abstractness, separation, and emphasis.

  • Eriksson, David
    et al.
    University of Borås, Sweden.
    Hilletofth, Per
    University of Skövde, Sweden.
    The Role of Consumer Insight in New Product Development and Its Impact on Supply Chain Management: A Swedish Case Study2010In: Innovative Process Optimization Methods in Logistics: Emerging trends, concepts and technologies / [ed] Thorsten Blecker, Wolfgang Kersten, Christian Lüthje, Berlin, 2010, 113-126 p.Conference paper (Refereed)
    Abstract [en]

    This paper seeks to explore how a profound consumer understanding may influence the early stages of a new product development (NPD) process. The issue is examined through a qualitative single case study combined with a literature review. The case study shows how the NPD process is structured and executed in a Swedish furniture company as well as the role consumer insight plays in that process. Empirical data have been collected mainly from in-depth interviews with persons representing senior and middle management in the case company. The research reveals that consumer oriented, cross-functional NPD in the case company has a strong impact on internal collaboration, and aligns the goals between different departments and functions within the company. Despite inefficiencies on departmental level, effectiveness on company level is achieved. Early indications show an expected growth in contribution margins by 8 percentage.

  • Hansson, Martin
    et al.
    SMHI, Core Services.
    Andersson, Lars
    SMHI, Core Services.
    Oxygen Survey in the Baltic Sea 2016 - Extent of Anoxia and Hypoxia, 1960-20162016Report (Other academic)
  • Karlsson, Stefan
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, Glafo Glasforskningsinstitutet. Friedrich Schiller University of Jena , Jena, Germany .
    Sharafat, Ali
    Linnæus University, Växjö, Sweden .
    Limbach, Rene
    Friedrich Schiller University of Jena, Jena, Germany .
    Strand, Michael
    Linnæus University, Växjö, Sweden .
    Wondraczek, Lothar
    Friedrich Schiller University of Jena, Jena, Germany .
    Alkali salt vapour deposition and in-line ion exchange on flat glass surfaces2015In: European Journal of Glass Science and Technology. Part A: Glass Technology, ISSN 1753-3546, Vol. 56, no 6, 203-213 p.Article in journal (Refereed)
    Abstract [en]

    This study suggests a different route for the modification of flat/float glass surfaces; i.e. exchange of ionic species originating from in-line vapour deposition of salt as compared to the conventional route of immersing the glass in a molten salt bath. The aim of this work is to develop a more flexible and, eventually, more rapid process for improving the mechanical strength of flat glass by introducing external material into the surface. We discuss how chemical strengthening can be performed through the application of potassium chloride on the glass surface by vapour deposition, and in-line thermally activated ion exchange. The method presented here has the potential to be up-scaled and to be used in in-line production in the future, which would make it possible to produce large quantities of chemically strengthened flat glass at a considerably lower cost.

  • Public defence: 2017-03-03 13:15 B/B42, Uppsala
    Mehić, Merima
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    Regulation of Hyaluronan Synthesis and Signaling via CD44 in Cancer2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Hyaluronan is a ubiquitous glycosaminoglycan which is an important constituent of the extracellular matrix (ECM). In addition to organizing the extracellular matrix and regulating tissue homeostasis, hyaluronan, by binding to its main cell surface receptor CD44, is involved in intracellular signaling pathways regulating major cellular processes during development, wound healing, inflammation and cancer. Accumulation of hyaluronan in cancer promotes progression of the disease and correlates with poor prognosis. This thesis focuses on the regulation of hyaluronan synthesis and its signaling in normal and cancer cells.

    Cancer cells in solid tumors are surrounded by stroma, which has an essential role in the growth and metastasis of tumors. Prominent members of the tumor stroma are fibroblasts, which synthesize ECM components, such as hyaluronan, and secrete growth factors, and activate intracellular signaling pathways. We demonstrate a cross-talk between the receptors for platelet-derived growth factor BB (PDGF-BB), transforming growth factor β (TGFβ) and CD44 in dermal fibroblasts. We found that PDGF-BB can activate the Smad signaling pathway downstream of the TGFβ receptor I (TβRI), and that PDGF-BB-induced migration depends on TβRI. CD44 forms a ternary complex with the receptors for PDGF-BB and TGFβ, and negatively regulates their signaling. Furthermore, we demonstrate that TGFβ stimulation of mammary epithelial cells transcriptionally upregulates hyaluronan synthase 2 (HAS2), which is essential for TGFβ-induced epithelial-mesenchymal transition (EMT); in this process, polarized epithelial cells adapt a mesenchymal phenotype which facilitates migration and invasion.

    HAS2 protein activity and stability is regulated by posttranslational modifications, including ubiquitination. We investigated the ubiquitination of HAS2 in aggressive breast cancer cells, whose metastasizing capability depends on HAS2-synthesized hyaluronan. We identified two deubiquitinating enzymes, USP4 and USP17, which target HAS2 and affect its activity and stability.

    In summary, these studies increase the knowledge about the regulation of hyaluronan production and its role in cancer progression.

  • Thapa, Devinder
    et al.
    University of Agder.
    Hatakka, Mathias
    Dalarna University, School of Technology and Business Studies, Information Systems.
    Understanding ICT in ICT4D: An Affordance Perspective2017In: Proceedings of the 50th Hawaii International Conference on System Sciences (HICSS), 2017Conference paper (Refereed)
    Abstract [en]

    Understanding the role of ICT for development is at the core of ICT4D research. However, prevailing research in this field most often focuses on access or readiness of a technology, or on the outcomes of the technology use. Less attention has been paid to understand the mechanism of the technology use that leads to the outcomes. The question of why ICT in a development context sometimes work and sometimes does not work still remains a subject of enquiry. To enhance our understanding in this regard, we propose to use the concept of affordances to unfold the “black boxed” nature of ICT. We revisited a case from Kenya to illustrate the application of affordances in a ICT4D context. The findings show that the benefits of ICT can be harnessed only if the users in the underprivileged communities can perceive and actualize the affordances of the ICT. However, what is ICT affordances, and how people perceive and actualize the affordances in the context of developing countries are the issues that we delve in this paper

  • Sandberg, Erik
    et al.
    Linköping university, Sweden.
    Jafari, Hamid
    Jönköping University, School of Engineering, JTH, Industrial Engineering and Management. Jönköping University, Jönköping International Business School, JIBS, Media Management and Transformation Centre (MMTC).
    Retail supply chain responsiveness: A systematic literature review and future research agenda2016In: NOFOMA 2016 - Proceedings of the 28th Annual Nordic Logistics Research Network Conference, Turku: University of Turku , 2016, 719-721 p.Conference paper (Refereed)
  • Nilsen, Morgan
    University West, Department of Engineering Science, Division of Production System.
    Optical detection of joint position in zero gap laser beam welding2017Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis presents an experimental study on how to track zero gaps between metal sheets to be joined by laser beam butt welding. Automated laser beam welding is gaining interest due to its ability to produce narrow and deep welds giving limited heat input and therefore less distortions compared to other processes, such as arc-welding. The automated laser beam welding process is however sensitive to how the high power laser is positioned with regards to the joint position. Deviations from the joint position may occur due to inaccuracies of the welding robot and fixturing, changes in joint geometry, process induced distortions, etc. Welding with an offset from the joint position can result inlack of sidewall fusion, a serious defect that is hard to detect. This work develops and evaluates three monitoring systems to be used during welding in order to be able to later control the laser beam spot position. (i) A monitoring systemis developed for three different photo diodes, one for the visual spectrum of the process emissions, one for the infrared spectrum, and one for the reflected highpower laser light. The correlation between the signals from the photodiodes and the welding position relative to the joint is analysed using a change detection algorithm. In this way an indication of a path deviation is given. (ii) A visual camera with matching illumination and optical filters is integrated into the laser beam welding tool in order to obtain images of the area in front of the melt pool. This gives a relatively clear view of the joint position even during intense spectral disturbances emitted from the process, and by applying animage processing algorithm and a model based filtering method the joint positionis estimated with an accuracy of 0.1 mm. (iii) By monitoring the spectral emissions from the laser induced plasma plume using a high speed and high resolution spectrometer, the plasma electron temperature can be estimated from the intensities of two selected spectral lines and this is correlated to the welding position and can be used for finding the joint position.

  • Fagerström, Arne
    et al.
    University of Gävle, Faculty of Education and Business Studies, Department of Business and Economic Studies, Business administration.
    Hartwig, Fredrik
    Högskolan Dalarna.
    Cunningham, Gary
    University of Gävle, Faculty of Education and Business Studies, Department of Business and Economic Studies, Business administration.
    Accounting and Auditing of Sustainability: Sustainable Indicator Accounting (SIA)2017In: Sustainability: The Journal of Record, ISSN 1937-0695, Vol. 10, no 1, 45-52 p.Article in journal (Refereed)
    Abstract [en]

    With sustainability reporting commonplace and mandatory in the E.U., a model to facilitate accumulation and assurance of sustainability information is needed. Currently, only limited assurance is possible, and comparability among reporting companies and over time is difficult if not impossible. Current standards of the U.S. Sustainability Accounting Standards Board (SSAB), while a good start, are not sufficiently broad. The current financial reporting framework, while not appropriate for sustainability, provides a basis for a sustainability accounting and auditing model by considering objectives, postulates, consolidation, and sustainability indicators for sustainability accounting.

    The overall focus of sustainability accounting and assurance is risk assessment, which is based on sustainability from the perspective of all stakeholders—financial, social, environmental, and technological—and management of the risk.

    Assumptions of sustainability accounting are developed from postulates of financial accounting and include:

    The reporting entity includes consolidated groups as well as disaggregation by product group, country, parts of the organization over which it has direct control and others over which it has indirect control such as suppliers, disposal organizations. The framework and model can be reviewed for independent assurance, and are comparable over time and among reporting entities.

  • Public defence: 2017-03-03 10:00 Hörsal 1031, Norra beteendevetarhuset, Umeå
    Knekta, Eva
    Umeå University, Faculty of Social Sciences, Department of applied educational science.
    Motivational aspects of test-taking: measuring test-taking motivation in Swedish national test contexts2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The overall aim of the work underlying this thesis was to improve the understanding of students’ test-taking motivation in connection to achievement tests for young adolescents. The thesis includes four studies and a summary. All four studies explore test-taking motivation and are all connected to validity in one way of another. The expectancy-value theory of achievement motivation was used as a theoretical framework in the operationalization and measurement of test-taking motivation and the achievement tests in focus were the Swedish national test in science for grade nine students, a Swedish national test in mathematics for upper secondary students and field trials for both these tests.

    In the first study psychometric properties of an expectancy-value based questionnaire measuring five aspects of test-taking motivation were evaluated. Findings provided support for construct validity, as internal structure of the data corresponded to the theoretical model, partial scalar invariance was obtained and correlations between test-taking motivation and test performance were found. In the second study the students’ test-taking motivation at the field trial and the national test were analysed in more detail. The analyses showed a significant increase in all test-taking motivation aspects between the field trial and the regular national test. Test-taking motivation at the field trial did also differ between school classes and test anxiety and expectancies differed between females and males. Further, effort, expectancies, importance and interest were significant predictors of test score after preliminary grades had been accounted for. The third study was an interview study aiming to examine students’ test-taking motivation at national test as well as the field trial in more depth. The interviews provided a rich understanding of the different aspects of test-taking motivation as described by the expectancy-value theory, for example why students find the national test important and what they mean by giving effort to a test. In the fourth study psychometric properties of an extended and revised test-taking motivation questionnaire were evaluated in a new sample of students. The analysis showed that the questionnaire had sound psychometric properties and supported the assumption that test-taking motivation consists of several distinctly different aspects, but also showed that the different subscales are highly related.

    In conclusion, the results provide support for several aspects of construct validity of the test-taking motivation questionnaire. Further, all studies showed that test-taking motivation differ between test with different stakes as well as between students and classes taking similar tests. Test-taking motivation also seem to affect test results. Thus, all students do not seem to be equally motivated to do their best on all tests and consideration should be taken to how students approach and experience each specific test when planning and interpreting achievement tests. 

  • Public defence: 2017-03-03 09:00 KB.E3.01, Umeå
    Ranjbarian, Farahnaz
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Targets and strategies for drug development against human African sleeping sickness2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Trypanosoma brucei is a causative agent of African sleeping sickness. It is an extracellular parasite which circulates in the blood, lymph and eventually invades the central nervous system. There is a great need for new medicines against the disease and specific properties of nucleoside kinases in the pathogen can be exploited as targets for chemotherapy. 

    T. brucei contains a gene where two thymidine kinase sequences are fused into a single open reading frame. These types of tandem thymidine kinases were found only in different types of parasites, which made us to believe that it might be beneficial for them. Each thymidine kinase sequence in these tandem enzymes are here referred to as a domain. By cloning and expressing each domain from T. brucei separately, we found that domain 1 was inactive and domain 2 was as active as the full-length enzyme. T. brucei thymidine kinase phosphorylated the pyrimidine nucleosides thymidine and deoxyuridine and to some extent purine nucleosides like deoxyinosine and deoxyguanosine. Human thymidine kinase increases the affinity to its substrates when it forms oligomers. Similarly, the T. brucei two thymidine kinase sequences, which can be viewed as a pseudodimer, had a higher affinity to its substrates than domain 2 alone. 

    T. brucei lacks de novo purine biosynthesis and it is therefore dependent on salvaging the required purine nucleotides for RNA and DNA synthesis from the host. Purine salvage is considered as a target for drug development. It has been shown that in the presence of deoxyadenosine in the growth medium, the parasites accumulate high levels of dATP and the extensive phosphorylation of deoxyadenosine leads to depleted ATP pools. Initially, we wondered if deoxyadenosine could be used as a drug against T. brucei. However, we found that T. brucei is partially protected against deoxyadenosine because it was cleaved by the enzyme methylthioadenosine phosphorylase (MTAP) to adenine and ribose-1-phosphate. At higher concentration of deoxyadenosine, 3 the formed adenine was not efficiently salvaged into ATP and started to inhibit MTAP instead. The deoxyadenosine was then instead phosphorylated by adenosine kinase leading to accumulation of dATP. The MTAP reaction makes deoxyadenosine itself useless as a drug and instead we focused on finding analogues of deoxyadenosine or adenosine that were cleavage-resistant and at the same time good substrates of T. brucei adenosine kinase. Our best hit was then 9-(2-deoxy-2-fluoro-ß-D-arabinofuranosyl) adenine (FANA-A). An additional advantage of FANA-A as a drug was that it was taken up by the P1 nucleoside transporter family, which makes it useful also against multidrug resistant parasites that often have lost the P2 transporter function and take up their purines solely by the P1 transporter. In parallel with our study of nucleoside metabolism in T. brucei, we also have a collaboration project where we screen essential oils from plants which are used in traditional medicine. If the essential oils are active against the trypanosomes, we further analyze the different components in the oils to identify new drugs against African sleeping sickness. One such compound identified from the plant Smyrnium olusatrum is isofuranodiene, which inhibited T. brucei proliferation with an IC50 value of 3 μM.

  • Premat, Christophe
    Stockholm University, Faculty of Humanities, Department of Romance Studies and Classics.
    L'actualité d'une pensée politique: La société bureaucratique, écrits politiques, 1945-1997, tome V2017In: Pouvoirs locaux, ISSN 0998-8289, Vol. 1, no 109, 139-142 p.Article, book review (Refereed)
  • Nielsen, Karsten H
    et al.
    University of Jena, Jena, Germany.
    Karlsson, Stefan
    RISE, SP – Sveriges Tekniska Forskningsinstitut, Glafo Glasforskningsinstitutet. University of Jena, Jena, Germany.
    Limbach, Rene
    University of Jena, Jena, Germany.
    Wondraczek, Lothar
    University of Jena, Jena, Germany.
    Quantitative image analysis for evaluating the abrasion resistance of nanoporous silica films on glass2015In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, 17708Article in journal (Refereed)
    Abstract [en]

    The abrasion resistance of coated glass surfaces is an important parameter for judging lifetime performance, but practical testing procedures remain overly simplistic and do often not allow for direct conclusions on real-world degradation. Here, we combine quantitative two-dimensional image analysis and mechanical abrasion into a facile tool for probing the abrasion resistance of anti-reflective (AR) coatings. We determine variations in the average coated area, during and after controlled abrasion. Through comparison with other experimental techniques, we show that this method provides a practical, rapid and versatile tool for the evaluation of the abrasion resistance of sol-gel-derived thin films on glass. The method yields informative data, which correlates with measurements of diffuse reflectance and is further supported by qualitative investigations through scanning electron microscopy. In particular, the method directly addresses degradation of coating performance, i.e., the gradual areal loss of antireflective functionality. As an exemplary subject, we studied the abrasion resistance of state-of-the-art nanoporous SiO2 thin films which were derived from 5–6 wt% aqueous solutions of potassium silicates, or from colloidal suspensions of SiO2 nanoparticles. It is shown how abrasion resistance is governed by coating density and film adhesion, defining the trade-off between optimal AR performance and acceptable mechanical performance.

  • Karlsson, Stefan
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, Glafo Glasforskningsinstitutet. University of Jena, Jena, Germany.
    Grund Bäck, Lisa
    Linnaeus University, Växjö, Sweden.
    Kidkhunthod, Pinit
    Synchrotron Light Research Institute, Nakhon Ratchasima, Thailand.
    Lundstedt, Karin
    RISE, SP – Sveriges Tekniska Forskningsinstitut, Glafo Glasforskningsinstitutet.
    Wondraczek, Lothar
    University of Jena, Jena, Germany.
    Effect of TiO2 on optical properties of glasses in the soda-lime-silicate system2016In: Optical Materials Express, Vol. 6, no 4, 1198-1216 p.Article in journal (Refereed)
    Abstract [en]

    Titania is widely considered as an alternative constituent for replacing heavy metal oxides in optical glasses. Its effect on optical properties, however, is complex. This is due to the dielectric properties of the prevalent ionic species, Ti4+, the potential co-existence of trivalent titanium, Ti3+, giving rise to intrinsic and extrinsic charge transfer reactions, and the existence of different coordination polyhedra, depending on matrix composition. Here, we present a systematic study of the optical properties of the soda-lime-silicate glass system as a function of TiO2 addition. We consider the silica-rich region of the SiO2-Na2O-CaO-TiO2 quaternary, which may be taken as model for a variety of technical glasses. Trends are described in the refractive index, the Abbe number, the optical bandgap and the Urbach energy. The addition of TiO2 increases the refractive index and the optical dispersion while it lowers the optical bandgap and the Urbach Energy. Results are discussed in relation to relevant literature data towards using titania silicate glasses as high-index replacements for heavy metal – containing oxide glasses.

  • El-Kemary, Maged
    et al.
    Kafrelsheikh Univ, Div Photo & Nanochem, Dept Chem, Fac Sci, Kafr Al Sheikh 33516, Egypt..
    Ibrahim, Eslam
    Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt..
    A-Ajmi, Mohammad F.
    King Saud Univ, Dept Pharmacognosy, Coll Pharm, POB 2457, Riyadh 11451, Saudi Arabia..
    Khalifa, Shaden A. M.
    Karolinska Univ Hosp, Dept Expt Hematol, SE-14186 Stockholm, Sweden.;Stockholm Univ, Dept Mol Biosci, Wenner Gren Inst, SE-10691 Stockholm, Sweden..
    Alanazi, A. D.
    Shaqra Univ, Coll Appl Med Sci, KSA, POB 1678, Aldawadmi 11911, Saudi Arabia..
    El-Seedi, Hesham R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy. Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt.;Uppsala Univ, Div Pharmacognosy, Dept Med Chem, Box 574, SE-75123 Uppsala, Sweden.;Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 50603, Malaysia..
    Calendula officinalis-mediated biosynthesis of Silver Nanoparticles and their Electrochemical and Optical Characterization2016In: International Journal of Electrochemical Science, ISSN 1452-3981, E-ISSN 1452-3981, Vol. 11, no 12, 10795-10805 p.Article in journal (Refereed)
    Abstract [en]

    The metal nanoparticles synthesis is highly explored field of nanotechnology. The biological methods seem to be more effective. A simple and elegant method is adopted to prepare Silver nanoparticles (AgNPs) in a single step using Calendula officinalis extract (COE) as reducing and stabilizing agent. The plant extract is mixed with AgNO3 to get biosynthesized AgNPs. The biosynthesized AgNPs were both optically and electrochemically characterized by UV-Vis, Infrared spectroscopy, Transmission Electron Microscopy, Fluorescence spectroscopy, Zeta potential and Cyclic Voltammetry. The results showed Calendula officinalis extract is a useful bioreductant for the synthesis of AgNPs. This study infers that the size of biosynthesized AgNPs ranges from 30 to 50 nm. The surface plasmon resonance peak in the UV-Vis absorption spectra shows maximum absorption at 435 nm. Fluorescence spectra of silver nanoparticles, which show an emission peak at 468 nm have also been studied. Zeta potential analysis ensured the biosynthesized AgNPs are highly stable. Using this environmentally friendly method of biological AgNPs production supplies rates of biosynthesis facile in comparison with other chemical and engineered routes. The employment of traditional medicine in biosynthesis protocols can potentially open new doors in various human health and well-being implications such as cosmetics, foods and medicine.

  • Falthin, Peter
    Royal College of Music in Stockholm, Department of Music Education.
    The Meaning of Making: Mapping Strategies in Music Composition2016In: International Conference on Music Perception anc Cognition, 14th Biennial Meeting: Proceedings / [ed] Theodore Zanto, San Francisco: University of California Press, 2016, 183-185 p.Conference paper (Refereed)
    Abstract [en]

    Abstract—One way to think of creative processes is as recontextualizations of perceptions and conceptions of reality. Impressions and ideas are seen from new perspectives and connected in new ways before entered into a new context in a different form, which may or may not include shifts in modality or form of representation. This study is about how composition students give musical expression to extra-musical phenomena and how they relate their musical thinking to other forms of representation. It involves studying what mapping strategies the student composers develop in order to establish relationships between different forms of representation, but also to study the meaning making processes in both the analysis and synthesis phase of the restructuring of concepts.

    The how-questions imply a qualitative approach and method. Data comprise a wide variety of sketch material, as well as scores, performances and recordings of the finalized compositions, and in-depth interviews with the student composers in relation to these materials. In all the studied cases, composition process began with extramusical considerations in the form of narratives, imagery or some kind of physical phenomena (e.g. geometrical concepts, acoustical phenomena and tactile qualities). Typically there would appear several creative processes in different modalities converging into musical form along the composition process. Results suggest that these students intend their music to represent extramusical phenomena and concepts in as far as they take that as points of departure for developing compositional concepts, but also for shaping musical expression. To a varying degree, these extramusical considerations are meant to be conveyed in the music. 

  • Wimo, Anders
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Aging Res Ctr, Stockholm, Sweden.;Stockholm Univ, Stockholm, Sweden.;Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Neurogeriatr, Stockholm, Sweden..
    Jonsson, Linus
    Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Aging Res Ctr, Stockholm, Sweden.;Stockholm Univ, Stockholm, Sweden..
    Fratiglioni, Laura
    Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Neurogeriatr, Stockholm, Sweden..
    Sandman, Per Olof
    Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Caring Sci, Stockholm, Sweden.;Umea Univ, Dept Nursing, Umea, Sweden.;Lulea Univ Technol, Dept Hlth Sci, Lulea, Sweden..
    Gustavsson, Anders
    Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Aging Res Ctr, Stockholm, Sweden.;Stockholm Univ, Stockholm, Sweden..
    Skoldunger, Anders
    Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Neurogeriatr, Stockholm, Sweden..
    Johansson, Lennarth
    Stockholm Gerontol Res Ctr, Stockholm, Sweden..
    The societal costs of dementia in Sweden 2012-relevance and methodological challenges in valuing informal care2016In: Alzheimer's Research & Therapy, ISSN 0065-6755, E-ISSN 1758-9193, Vol. 8, 59Article in journal (Refereed)
    Abstract [en]

    Background: In this study, we sought to estimate the societal cost of illness in dementia in Sweden in 2012 using different costing approaches to highlight methodological issues. Methods: We conducted a prevalence-based cost-of-illness study with a societal perspective. Results: The societal costs of dementia in Sweden in 2012 were SEK 62.9 billion (approximately (sic) 7.2 billion, approximately US$ 9.0 billion) or SEK 398,000 per person with dementia (approximately (sic) 45,000, approximately US$ 57,000). By far the most important cost item is the cost of institutional care: about 60% of the costs. In the sensitivity analysis, different quantification and costing approaches for informal care resulted in a great variation in the total societal cost, ranging from SEK 60 billion ((sic) 6.8 billion, US$ 8.6 billion) to SEK 124 billion ((sic) 14.1 billion, US$ 17.8 billion). Conclusions: The societal costs of dementia are very high. The cost per person with dementia has decreased somewhat, mainly because of de-institutionalisation. The majority of the costs occur in the social care sector, but the costing of informal care is crucial for the cost estimates.

  • Nordlund, Erling
    et al.
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Mining and Geotechnical Engineering.
    Jones, TristanLuleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Mining and Geotechnical Engineering. Luleå tekniska universitet.Eitzenberger, AndreasLuleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Mining and Geotechnical Engineering.
    Proceedings of the 8th International Symposium on Ground Support in Mining and Underground Construction2016Conference proceedings (editor) (Refereed)
  • Lampa, Samuel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Alvarsson, Jonathan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Spjuth, Ola
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Towards agile large-scale predictive modelling in drug discovery with flow-based programming design principles2016In: Journal of Cheminformatics, ISSN 1758-2946, E-ISSN 1758-2946, Vol. 8, 67Article in journal (Refereed)
    Abstract [en]

    Predictive modelling in drug discovery is challenging to automate as it often contains multiple analysis steps and might involve cross-validation and parameter tuning that create complex dependencies between tasks. With large-scale data or when using computationally demanding modelling methods, e-infrastructures such as high-performance or cloud computing are required, adding to the existing challenges of fault-tolerant automation. Workflow management systems can aid in many of these challenges, but the currently available systems are lacking in the functionality needed to enable agile and flexible predictive modelling. We here present an approach inspired by elements of the flow-based programming paradigm, implemented as an extension of the Luigi system which we name SciLuigi. We also discuss the experiences from using the approach when modelling a large set of biochemical interactions using a shared computer cluster.

  • Falthin, Peter
    et al.
    Royal College of Music in Stockholm, Department of Music Education.
    Dahlstedt, Palle
    Göteborgs universitet, IT-universitetet, Chalmers.
    Creative Structures or Structured Creativity?: Investigating algorithmic composition as a pedagogical tool2010In: The 11nth International Conference on Music Perception and Cognition (ICMPC11): Book of Abstracts / [ed] Steven M. Demorest, Steven J Morrison & Patricia S Campbell, Seattle: University of Washington Press, 2010, 125- p.Conference paper (Refereed)
    Abstract [en]

    CREATIVE STRUCTURES OR STRUCTURED CREATIVITY (Investigation algorithmic composition as a pedagogical tool) Peter Falthin, PalleDahlstedt Royal College of Music, Stockholm, Chalmers Technical University, Gothenburg peter.falthin@kmh.se palle@chalmers.se

    ABSTRACT

    This empirical study aims to depict how composers develop and structure creative resources, aided by algorithmic methods and other means of structuring material and processes. The project is not meant to be conclusive, but rather to form a point of departure and raise questions for further theoretical and empirical study in the field. Implications for teaching and learning composition and for designing interactive musical tools are expected. In specific, this paper concerns concept development within learning of music composition: if, how and to what extent this is comparable to that of language-based learning. The research project in progress sets out to study cognitive processes of composers working to integrate the outcome of composition algorithms, with the subjective compositional aim and modus operandi. However, in most cases the composer is also designer of the algorithm or at least of its specific application to the compositional problem. Consequently the strategies involved in designing and applying compositional algorithms need to be considered and discussed insofar that they too are part of the integration process. The study at hand draws from research conducted in cultural-historical psychology, cognitive psychology and linguistic theory, concerning internalization, development of concepts and syntactic and semantic aspects of musical structures. 

  • Public defence: 2017-03-08 10:00 Kollegiesalen, Stockholm
    Bjurström, Henrik
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Soil and Rock Mechanics.
    Non-contact surface wave measurements on pavements2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In this thesis, nondestructive surface wave measurements are presented for characterization of dynamic modulus and layer thickness on different pavements and cement concrete slabs. Air-coupled microphones enable rapid data acquisition without physical contact with the pavement surface.

    Quality control of asphalt concrete pavements is crucial to verify the specified properties and to prevent premature failure. Testing today is primarily based on destructive testing and the evaluation of core samples to verify the degree of compaction through determination of density and air void content. However, mechanical properties are generally not evaluated since conventional testing is time-consuming, expensive, and complicated to perform. Recent developments demonstrate the ability to accurately determine the complex modulus as a function of loading time (frequency) and temperature using seismic laboratory testing. Therefore, there is an increasing interest for faster, continuous field data evaluation methods that can be linked to the results obtained in the laboratory, for future quality control of pavements based on mechanical properties.

    Surface wave data acquisition using accelerometers has successfully been used to determine dynamic modulus and thickness of the top asphalt concrete layer in the field. However, accelerometers require a new setup for each individual measurement and are therefore slow when testing is performed in multiple positions. Non-contact sensors, such as air-coupled microphones, are in this thesis established to enable faster surface wave testing performed on-the-fly.

    For this project, a new data acquisition system is designed and built to enable rapid surface wave measurements while rolling a data acquisition trolley. A series of 48 air-coupled micro-electro-mechanical sensor (MEMS) microphones are mounted on a straight array to realize instant collection of multichannel data records from a single impact. The data acquisition and evaluation is shown to provide robust, high resolution results comparable to conventional accelerometer measurements. The importance of a perfect alignment between the tested structure’s surface and the microphone array is investigated by numerical analyses.

    Evaluated multichannel measurements collected in the field are compared to resonance testing on core specimens extracted from the same positions, indicating small differences. Rolling surface wave measurements obtained in the field at different temperatures also demonstrate the strong temperature dependency of asphalt concrete.

    A new innovative method is also presented to determine the thickness of plate like structures. The Impact Echo (IE) method, commonly applied to determine thickness of cement concrete slabs using an accelerometer, is not ideal when air-coupled microphones are employed due to low signal-to-noise ratio. Instead, it is established how non-contact receivers are able to identify the frequency of propagating waves with counter-directed phase velocity and group velocity, directly linked to the IE thickness resonance frequency.

    The presented non-contact surface wave testing indicates good potential for future rolling quality control of asphalt concrete pavements.

     

  • Nikjoo, Dariush
    et al.
    Department of Chemistry, Faculty of Engineering, Istanbul University, Avcilar.
    Aroguz, Ayse
    Department of Chemistry, Faculty of Engineering, Istanbul University, Avcilar.
    Magnetic field responsive methylcellulosepolycaprolactonenanocomposite gels for targeted and controlled release of 5-Fluorouracil2016In: International Journal of Polymeric Materials, ISSN 0091-4037, E-ISSN 1563-535X, Vol. 65, no 8, 421-432 p.Article in journal (Refereed)
    Abstract [en]

    5-Fluorouracil loaded magnetic field sensitive methylcellulose and polycaprolactone gels were prepared and characterized by FTIR, XRD, TGA, SEM, and VSM. Swelling analysis supplied important information on drug diffusion properties. The release profile of gels was investigated in different buffer solutions and the highest release values were observed at pH = 7.2. Release kinetic was analyzed using an empirical equation to clarify the transport properties of drug. The effects of nanoparticle concentration and applying external magnetic field were investigated on release profile. The results indicated that the drug release decreased by both, applying external magnetic field and increasing the concentration of Fe3O4 nanoparticles.

  • Hilletofth, Per
    et al.
    University of Skövde, Sweden.
    Ericsson, Dag
    University College of Borås, Sweden.
    Hilmola, Olli-Pekka
    Lappeenranta University of Technology, Finland and University of Skövde, Sweden.
    Ujvari, Sandor
    University of Skövde, Sweden.
    Differentiated Supply Chains Strategies Based on Customer Insights2008In: Proceedings of the 18th International Conference on Flexible Automation and Intelligent Manufacturing (FAIM 2008), Skövde, 30/6-2/7, 2008., 2008Conference paper (Refereed)
    Abstract [en]

    Supply chains satisfy customers by striving for delivering the right products to the right place at the right time, atthe right quality and at the right quantity within an increasingly faster pace and lower cost. One implication thatcan be made from this is that the nature of markets is the point of departure in both supply chain design andoperations. Given that organizations usually offer a wide range of products and services with different supplyand demand characteristics, one could argue that organizations conduct business in various types of noncoherentbusiness environments. There has been a recognition that ‘one-size-fits-all’ supply chain strategies onlysatisfies a limited number of business environments, and that it is increasingly necessary to develop severaldifferentiated supply chain strategies to satisfy all major business environments in a better way. This paperemploys a descriptive case study approach to illustrate how a case company develops differentiated supplychains based on customer insights. Case study findings reveal that one efficient way to develop differentiatedsupply chain strategies is to combine different supply and delivery methods into supply chain solutions. Bycombining relatively few supply and delivery methods it is possible to develop several differentiated supply chainstrategies.

  • Public defence: 2017-03-03 09:00 Rosénsalen, Uppsala
    Christersson, Albert
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Fractures of the distal radius: Factors related to radiographic evaluation, conservative treatment and fracture healing2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Distal radius fractures (DRFs) are one of the most common injuries encountered in orthopaedic practise. Such fractures are most often treated conservatively, but surgical treatment has become increasingly common. This trend is not entirely scientifically based

    The aims of this thesis were threefold: to increase measurement precision in dorsal angulation (DA) on radiographs and computer tomographies (CTs); to assess the results after shortened plaster cast fixation time in reduced DRFs; and to evaluate the feasibility and safety of applying Augment® (rhPDGF-BB/β-TCP) in DRFs.

    In Paper I and Appendix 1 and 2, a semi-automatic CT-based three-dimensional method was developed to measure change in DA over time in DRFs. This approach proved to be a better (more sensitive) method than radiography in determining changes in DA in fractures of the distal radius.

    In Paper II, a CT model was used to simulate lateral radiographic views of different radial directions in relation to the X-ray. Using an alternative reference point on the distal radius, precision and accuracy in measuring DA was increased.

    Paper III and IV are based on a prospective and randomised clinical study (the GitRa trial) that compares clinical and radiographic outcomes after plaster cast removal at 10 days versus 1 month in 109 reduced DRFs. Three patients in the early mobilised group were excluded because of fracture dislocation (n=2) or a feeling of fracture instability (n=1). For the remaining patients in the early mobilised group (51/54) a limited but temporary gain in range of motion, but a slight increase in radiographic displacement were observed. Our results suggest that plaster cast removal at 10 days after reduction of DRFs is not feasible.

    Paper V is based on a prospective, randomised clinical study (the GEM trial) in which 40 externally fixated DRFs were randomised to rhPDGF-BB/β-TCP into the fracture gap or to the control group. Augment® proved to be convenient and safe during follow-up (24 weeks). However, because of the nature of the study design, the effect on fracture healing could not be determined. A decrease in pin infections was seen in the Augment® group, a finding we could not explain.

  • Zubkovych, Alina
    Reactivating the past: case study analysis of the non-museum-based Yugo-nostalgic exhibition in Serbia2015In: Raziskave in razprave /Research and Discussion, ISSN 1855-6280, Vol. 8, no 1, 99-129 p.Article in journal (Refereed)
    Abstract [en]

    With the dissolution of socialist Yugoslavia followed by ethnic cleansing, massacres, and the urbicides of large cities, such as Sarajevo, Vukovar or Mostar, the discourse of “brotherhood and unity” was suppressed, andany sense of it being genuine has been lost. The policy of multiculturalism was instantly transformed into a reemerged nationalist policy, and the institutions dealing with there presentation of the memory were reinforced in order to re-define, construct, or at least upgrade the new interpretation of the recent pastfrom the new national perspectives. Since the fall of the Miloševićregime, the politics of memory has been transformed into new sets of visual representations. One of them is the Yugo-nostalgic competing discourse that was visualized recently through a temporary exhibition based on a private initiative. In this article, the contemporary image ofthe given type of nostalgia through case study research of a Yugonostalgi cexhibition, which took place in Belgrade from October 2013 to January to 2014 is analyzed. The main elements, events andpersonalities that were selected for construction of the newly actualized trend are recounted.

  • Almas, Muhammad Shoaib
    et al.
    KTH, School of Electrical Engineering (EES), Electric Power and Energy Systems.
    Vanfretti, Luigi
    KTH, School of Electrical Engineering (EES), Electric Power and Energy Systems. Statnett.
    Singh, Ravi Shankar
    KTH, School of Electrical Engineering (EES), Electric Power and Energy Systems. KTH Royal Institute of Technology.
    Jonsdottir, Gudrun Margret
    KTH, School of Electrical Engineering (EES), Electric Power and Energy Systems. KTH Royal Institute of Technology.
    Vulnerability of Synchrophasor-based WAMPAC Applications’ to Time Synchronization Spoofing2017In: IEEE Transactions on Smart Grid, ISSN 1949-3053, E-ISSN 1949-3061, Vol. PP, no PP, 1-1 p.Article in journal (Refereed)
    Abstract [en]

    This paper experimentally assesses the impact of time synchronization spoofing attacks (TSSA) on synchrophasor-based Wide-Area Monitoring, Protection and Control applications. Phase Angle Monitoring (PAM), anti-islanding protection and power oscillation damping applications are investigated. TSSA are created using a real-time IRIG-B signal generator and power system models are executed using a real-time simulator with commercial phasor measurement units (PMUs) coupled to them as hardware-in-the-loop. Because PMUs utilize time synchronization signals to compute synchrophasors, an error in the PMUs’ time input introduces a proportional phase error in the voltage or current phase measurements provided by the PMU. The experiments conclude that a phase angle monitoring application will show erroneous power transfers, whereas the anti-islanding protection mal-operates and the damping controller introduces negative damping in the system as a result of the time synchronization error incurred in the PMUs due to TSSA.The proposed test-bench and TSSA approach can be used to investigate the impact of TSSA on any WAMPAC application and to determine the time synchronization error threshold that can be tolerated by these WAMPAC applications.

  • Zubkovych, Alina
    School of Advanced Social Studies, Nova Gorica, Slovenia.
    Interpreting the past: the competing memories of the Yugoslavian period through the case study analysis of Slovenian history museum and private exhibition2015In: Innovative Issues and Approaches in Social Sciences, ISSN 1855-0541, Vol. 8, no 1, 111-128 p.Article in journal (Refereed)
    Abstract [en]

    In the given article we analyze the representation of the period from the recent history- Socialist Yugoslavia- through the case study of national history museum and private exhibition. Although both of the analyzed objects are located in Ljubljana, the metastories which they construct and display are based on the different cultural patterns. We compare the differences of the narratives being used by the private and state institution and apply the visual analysis method together with semi-structured interviews for these purposes. As a result of our research, we show how differs ‘official narration’ compared to the so-called ‘Yugonostalgic’ or ‘Titostalgic’ viewpoint and describe their main characteristics.

  • Moritz, Thomas
    et al.
    Luleå tekniska universitet.
    Ejdemo, Thomas
    Luleå University of Technology, Department of Business Administration, Technology and Social Sciences, Social Sciences.
    Söderholm, Patrik
    Luleå University of Technology, Department of Business Administration, Technology and Social Sciences, Social Sciences.
    Wårell, Linda
    Luleå University of Technology, Department of Engineering Sciences and Mathematics, Energy Science.
    The local employment impacts of mining: an econometric analysis of job multipliers in northern Sweden2017In: Mineral Economics, ISSN 2191-2203, E-ISSN 2191-2211Article in journal (Refereed)
    Abstract [en]

    The way in which mining contributes to job opportunities in the region where it takes place has become increasingly important for the industry’s relations to the local community. The employment impacts of mining are however far from straightforward to assess. Considering these uncertainties about real-life job impacts, it is vital that there are sound assessments of these employment effects. The purpose of this paper is to apply a novel econometric approach to assess mining-induced job multipliers in the empirical context of northern Sweden. This analysis employs data on the number of employees in selected non-mining sectors and in the mining sector, respectively, and covering the relatively recent mining boom period (2003-2013). We also highlight differences across the two main mining counties in northern Sweden. The results show a positive statistical relationship between increases in the number of employees in the mining sector and changes in the number of employees in other sectors. The private services sector is particularly affected, while the industrial sector also benefits in the specific case of mining municipalities. The results also indicate relatively large inter-county differences, in turn highlighting the importance of addressing the context-specific circumstances when estimating the employment effects of mining.

  • Pilemalm, Sofie
    et al.
    Linköping University, Department of Management and Engineering, Information Systems. Linköping University, Faculty of Arts and Sciences.
    Lindgren, Ida
    Linköping University, Department of Management and Engineering, Information Systems. Linköping University, Faculty of Arts and Sciences.
    Ramsell, Elina
    Linköping University, Department of Management and Engineering, Information Systems. Linköping University, Faculty of Arts and Sciences.
    Emerging forms of inter-organizational and cross-sector collaborations in e-government initiatives: Implications for participative development of information systems2016In: Transforming Government: People, Process and Policy, ISSN 1750-6166, E-ISSN 1750-6174, Vol. 10, no 4, 605-636 p.Article in journal (Refereed)
    Abstract [en]

    Purpose – This study aims to explore recent public sector trends, inter-organizational and cross-sector

    collaborations, and analyzes these in terms of implications for participative development of information

    systems (IS). These trends are understood as being part of emerging forms of e-government. Initial

    suggestions for how to develop IS in the new contexts are provided.

    Design/methodology/approach – Three cases involving the trends described above, taking place in

    the Swedish emergency response system, are studied and used as basis for identified participative IS

    development challenges and suggested adaptation needs. Data collection involves semi-structured

    interviews, focus groups and future workshops.

    Findings – The identified challenges concern balancing ideological versus practical needs, lack of

    resources, lack of know-how and design techniques and tool challenges. Some practical implications for

    participative IS development include more extensive focus on stakeholder and legal analysis, need for

    interdisciplinary design teams, merging of task and needs analysis for yet-undefined user tasks and

    using on-line alternatives for interacting with users.

    Research implications/limitations – The study is exploratory where the three cases are in

    different, but at the same time interrelated, collaboration contexts. The identified implications and

    challenges provide proposals that in future research can be applied, formalized and integrated when

    developing practically feasible participative IS development approaches.

    Originality/value – It is argued that the results point toward a current emerging form of

    e-government initiatives directed toward certain demarcated groups of citizens actually carrying out

    certain tasks for their co-citizens and society rather than the broad masses, having far-reaching

    practical implications and complicating the issue of IS development.

  • Clement, Jan
    et al.
    Univ Hosp Leuven, Rega Inst Med Res, Natl Reference Ctr Hantavirus Infect, Lab Clin & Epidemiol Virol, Leuven, Belgium..
    Maes, Piet
    Univ Hosp Leuven, Rega Inst Med Res, Natl Reference Ctr Hantavirus Infect, Lab Clin & Epidemiol Virol, Leuven, Belgium..
    Saegeman, Veroniek
    Univ Hosp Leuven, Lab Med, Leuven, Belgium.;Univ Hosp Leuven, Dept Microbiol & Immunol, Leuven, Belgium..
    Lagrou, Katrien
    Univ Hosp Leuven, Lab Med, Leuven, Belgium.;Univ Hosp Leuven, Dept Microbiol & Immunol, Leuven, Belgium..
    Van Ranst, Marc
    Univ Hosp Leuven, Rega Inst Med Res, Natl Reference Ctr Hantavirus Infect, Lab Clin & Epidemiol Virol, Leuven, Belgium.;Univ Hosp Leuven, Lab Med, Leuven, Belgium.;Univ Hosp Leuven, Dept Microbiol & Immunol, Leuven, Belgium..
    Lundkvist, Åke
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Univ Uppsala Hosp, Lab Clin Microbiol, Uppsala, Sweden..
    Comment on "A Cluster of Three Cases of Hantavirus Pulmonary Syndrome among Canadian Military Personnel"2016In: CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY, ISSN 1712-9532, 7458409Article in journal (Refereed)
  • Forchini, Giovanni
    et al.
    Peng, Bin
    A conditional approach to panel data models with common shocks2016In: Econometrics, ISSN 2225-1146, Vol. 4, no 1, 4Article in journal (Refereed)
    Abstract [en]

    This paper studies the effects of common shocks on the OLS estimators of the slopes' parameters in linear panel data models. The shocks are assumed to affect both the errors and some of the explanatory variables. In contrast to existing approaches, which rely on using results on martingale difference sequences, our method relies on conditional strong laws of large numbers and conditional central limit theorems for conditionally-heterogeneous random variables.

  • Somarriba, Oscar
    et al.
    Electronics and Computing Department, Mondragon University, Mondragon, Spain; National University of Engineering (UNI), P.O. Box 5595, Managua, Nicaragua .
    Zurutuza, Urko
    Electronics and Computing Department, Mondragon University, Mondragon, Spain.
    Uribeetxeberria, Roberto
    Electronics and Computing Department, Mondragon University, Mondragon, Spain.
    Delosierés, Laurent
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Nadjm-Tehrani, Simin
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Detection and Visualization of Android Malware Behavior2016In: Journal of Electrical and Computer Engineering, ISSN 2090-0147, Vol. 2016, 8034967Article in journal (Refereed)
    Abstract [en]

    Malware analysts still need to manually inspect malware samples that are considered suspicious by heuristic rules. They dissect software pieces and look for malware evidence in the code. The increasing number of malicious applications targeting Android devices raises the demand for analyzing them to find where the malcode is triggered when user interacts with them. In this paper a framework to monitor and visualize Android applications’ anomalous function calls is described. Our approach includes platform-independent application instrumentation, introducing hooks in order to trace restricted API functions used at runtime of the application. These function calls are collected at a central server where the application behavior filtering and a visualization take place. This can help Android malware analysts in visually inspecting what the application under study does, easily identifying such malicious functions.