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  • Parkhouse, Anna
    Dalarna University, School of Education, Health and Social Studies, Political Science.
    Dags att ta EU:s existentiella problem på allvar2014Other (Other (popular science, discussion, etc.))
  • Nerhagen, Lena
    et al.
    Swedish National Road and Transport Research Institute, Society, environment and transport, Transport economics.
    Fors, Heather Congdon
    Göteborgs universitet.
    Hansson, Lisa
    Högskolen i Molde, Norge.
    Hammes, Johanna Jussila
    Konjunkturinstitutet.
    Pyddoke, Roger
    Swedish National Road and Transport Research Institute, Society, environment and transport, Transport economics.
    Politiska krav och tjänstemäns roll för analys av och beslut om styrmedel: Sammanfattande slutrapport2018Report (Other academic)
    Abstract [en]

    Sustainable development implies that society’s limited resources should be used efficiently, taking into account the various impacts on society – social, economic and environmental. To achieve established societal goals efficiently, various aspects have to be accounted for in the design of policy measures. Within the EU a Regulatory Impact Assessment, where a cost-benefit analysis is included, needs to accompany all major regulatory initiatives. According to research and different policy assessment, Sweden lacks an established praxis regarding this type of analysis in the area of environmental policy but also in the field of energy and transport. The purpose of this project is to investigate how Sweden uses this type of information in the negotiations that take place within the EU regarding policy proposals but also investigate the reasons for use or non-use. The focus is on what role the organization and the bureaucrats play for the collection of this type of information.

    The overall conclusion that can be drawn from the three sub-studies included in the project, as well as the discussion at the closing seminar, is that this is not an established way of working in the Swedish government system. This can be explained by lack of competence, an established mistrust, management by objectives and lack of an institutional framework for when and how this type of broader impact assessment is to be conducted. At the closing seminar, the Swedish Environmental Protection Agency presented that it is now working on a guide to help officials to analyze at an early stage whether there is a need for regulation by society, to initiate the work by asking the question “What is the problem?”. We think that this is a step in the right direction, but we also see that the economists working out in government are often alone or very few and may therefore need different forms of support to develop the work on this kind of, often complex, analysis.

  • Nilsson, Monica
    et al.
    Jönköping University, School of Education and Communication, HLK, Praktiknära utbildningsforskning (PUF), Preschool Education research.
    Lecusay, Robert
    Jönköping University, School of Education and Communication, HLK, Praktiknära utbildningsforskning (PUF), Preschool Education research.
    Alnervik, Karin
    Jönköping University, School of Education and Communication, HLK, Praktiknära utbildningsforskning (PUF), Preschool Education research.
    Undervisning i förskolan: Holistisk förskoledidaktik byggd på lek och utforskande2018In: Utbildning och Demokrati, ISSN 1102-6472, E-ISSN 2001-7316, Vol. 27, no 1, p. 9-32Article in journal (Refereed)
    Abstract [en]

    In this article we critically examine and problematizethe concept of teaching in contemporary Swedish preschoolprovision, and sketch a holistic preschool didactics aimed at addressingkey problems that emerge from the implementation of the concept ofteaching in preschool. We briefly survey how teaching is conceptualizedand managed from different theoretical perspectives and institutionaldiscourses. Drawing on cultural historical activity theory and situatedlearning approaches, we argue for the formation of a preschool didacticsbased on a socio-cultural understanding of play in combination with aReggio Emilia-inspired understanding of exploratory and project-basedwork methods.

  • Samordnad skadedjurskontroll, IPM: att initiera arbetet med samordnad skadedjurskontroll2018Other (Other academic)
    Abstract [sv]

    Det ska vara tydligt för alla i personalen vem som ansvarar för vad inom skadedjursarbetet. En ansvarig IPM-koordinator utses och en IPM-policy med tillhörande rutiner antas. Arbetet är ständigt pågående med utvärderingar av insatser, uppdaterade riskbedömningar och nya prioriteringar. Detta Vårda väl-blad ingår i en serie om samordnad skadedjurskontroll och vänder sig till alla som förvaltar samlingar och särskilt till dig som är IPM-koordinator.

  • Carlsson, Ulla
    et al.
    Nordic Council of Ministers, NORDICOM. Department of Journalism, Media and Communication, University of Gothenburg.
    Weibull, Lennart
    The SOM Institute.
    Freedom of Expression in the Digital Media Culture: A study of public opinion in Sweden2018Book (Other academic)
    Abstract [en]

    Freedom of expression is fundamental to democracy, and media serve as custodians of that freedom. Prevailing norms and values among the populace constitute the preconditions for freedom of expression, but also determine its limits. Digital technology has democratized the public sphere, but the new technologies also imply problems concerning the limits of freedom of expression. Particularly problematic is the relationship between freedom of expression and personal integrity. 

    The present study reports on a national representative survey of Swedish citizens’ views on the limits of freedom of expression and on the areas in which limitations of freedom of expression may be acceptable. Public acceptance of possible curtailment of freedom of expression may be taken to represent dissatisfaction with the ways in which contemporary media operate.

  • Graf, Heike
    Södertörn University, School of Culture and Education, Media and Communication Studies.
    Media Practices an Forced Migration: Trust Online and Offline2018In: Media and Communication, ISSN 2083-5701, E-ISSN 2183-2439, Vol. 6, no 2, p. 149-157Article in journal (Refereed)
    Abstract [en]

    This article explores the relationship between online and offline practices in the special case of forced migration. By applying a central category in social relations, trust/distrust as developed by Niklas Luhmann, this article contributes to the understanding of forced migration in the digital age. It presupposes that, without a strategy of trust, it would be almost impossible to cope with situations of unfamiliarity and uncertainty. By interviewing refugees, the questionis in what contexts the refugee recognizes that they can trust (or not). The article concludes that through the combination of on- and offline communication practices, more varied mechanisms for the creation and stabilization of trust are provided. In contexts of unfamiliarity, interpersonal relations with the native inhabitants play an important role in bridging online and offline worlds.

  • Harrie, Eva (Editor)
    Nordic Council of Ministers, NORDICOM.
    Newspapers in the Nordic Media Landscape 20172018Collection (editor) (Other academic)
    Abstract [en]

    The Nordic region has traditionally been characterized as a “newspaper region”, with high circulation and extensive readership. But contemporary trends of globalisation and digitization have profoundly changed the media landscape and the way we use media, and have put the strong position of the Nordic newspaper markets under pressure. 

    This volume, Newspapers in the Nordic Media Landscape 2017, is an attempt to map the development of the Nordic newspaper industries, looking at the trends from 2000 onward. It offers unique statistical time series on the structure of the newspaper landscape in Denmark, Finland, Iceland, Norway and Sweden (number of newspapers, circulation, etc.); the economy of the newspaper markets (advertising and audience revenues, indirect and direct state support, etc.); and reading trends (print and digital).

    The publication is divided into two sections: the first presenting the Nordic media and newspaper landscape in commentaries and graphs, and the second providing detailed newspaper statistics.

    Moreover, a thorough presentation of the statistical sources and surveys used in the publication provides a guide for further exploration of national or Nordic newspaper trends.

  • Lindroth, Malin
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Nursing Science. Jönköping University, School of Health and Welfare, HHJ. ADULT.
    Schindele, Anna-ChuChu
    Folkhälsomyndigheten.
    Fridlund, Veronika
    Folkhälsomyndigheten.
    Sexualitet och hälsa bland unga och unga vuxna inom statlig institutionsvård: En studie om kunskap, attityder och beteende bland unga och unga vuxna 16–29 år2018Report (Other academic)
  • Fritsche, Carsten
    et al.
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, Faculty of Science & Engineering.
    Orguner, Umut
    Middle East Technical University, Turkey.
    Supplementary Material for “Bobrovsky-Zakai Bound for Filtering, Prediction and Smoothing of Nonlinear Dynamic Systems”2018Report (Other academic)
    Abstract [en]

    This report contains supplementary material for the paper [1], and gives detailed proofs of all lemmas and theorems that could not be included into the paper due to space limitations. The notation is adapted from the paper.

    [1] C. Fritsche, U. Orguner, and F. Gustafsson, “Bobrovsky-Zakai bound for filtering, prediction and smoothing ofnonlinear dynamic systems,” in International Conference on Information Fusion (FUSION), Cambridge, UK, Jul.2018, pp. 1–8.

  • Frisk, Henrik
    Royal College of Music in Stockholm, Department of Composition and Conducting.
    ArtDoc - an Experimental Archive and a Tool for Artistic Research2017Conference paper (Refereed)
    Abstract [en]

    ArtDoc is an experimental database and archive for primarily

    documentation of artistic content. It attempts to address the question

    of the diculty of documenting artistic practice in a manner that makes

    visible the processes in action. The background to this project is discussed

    and the theory behind the development of open works. Though

    ArtDoc is still under construction the foundation of the archive is presented.

    Finally some thoughts on the future of digital documentation

    systems is discussed.

  • Frisk, Henrik
    Royal College of Music in Stockholm, Department of Composition and Conducting.
    Hell is full of musical amateurs, but so is heaven2017In: Seismograf, ISSN 2245-4705Article in journal (Refereed)
    Abstract [en]

    Today, whenwe think of musical performance inWestern art music, it is easy to take

    for granted the division of labor between, for example, musician and composer. However,

    music has obviously been produced for many thousands of years without there

    being a need to compose and write it down before playing it. Most genres of music have

    sustained and developed without this split between creator and performer. In genres

    where improvisation play an important role the musician sometimes embodies both the

    creative act and the interpretative–simultaneously. In musics built on aural traditions

    the composed component is integrally bound to the musician. However, as advanced

    and standardized technologies for systematic notation of music were developed in Europe

    the role of the musician slowly began to evolve into two, often separate parts: one

    part primarily responsible for the construction of music (composer), and one part primarily

    responsible for the performance of it (musician). There is no doubt that composition

    and notation are extraordinarily ecient means to structure, communicate and

    preserve musical ideas and it is fair to assume that the development that led to the division

    of labor loosely sketched here participated in the advancement ofWestern music

    into new aesthetic areas.

  • Larsson, Ingrid
    et al.
    Halmstad University, School of Health and Welfare, Centre of Research on Welfare, Health and Sport (CVHI), Health and Nursing.
    Nyman, Carin
    Halmstad University, School of Health and Welfare, Centre of Research on Welfare, Health and Sport (CVHI).
    Svedberg, Petra
    Halmstad University, School of Health and Welfare, Centre of Research on Welfare, Health and Sport (CVHI), Health and Nursing.
    Nygren, Jens M.
    Halmstad University, School of Health and Welfare, Centre of Research on Welfare, Health and Sport (CVHI), Health and Nursing.
    Carlsson, Ing-Marie
    Halmstad University, School of Health and Welfare, Centre of Research on Welfare, Health and Sport (CVHI).
    Children and young people’s participation in developing interventions in health and well-being: a scoping review2018In: BMC Health Services Research, ISSN 1472-6963, E-ISSN 1472-6963, Vol. 18, no 1, article id 507Article, review/survey (Refereed)
    Abstract [en]

    Background: Greater interest is being shown in participatory approaches, especially in research on interventions that concern children and young people’s health and well-being. Although participatory approaches have user involvement in common, they differ in terms of the explicit guidance on how to actually involve and engage children and young people in health research. The aim of this scoping review was to systematically map recent research involving children and young people in the development of interventions targeting issues of health and well-being.

    Methods: An interpretative scoping literature review based on: a scientific literature search in (health and social science) databases, reference lists, a manual search in key journals and contact with existing networks was conducted. A total of 4458 references were identified through the literature search, of which 41 studies published between 2000 and 2017 were included in the review. The target population was children and young people under 25 years old. Level of participation was categorized according to Shier’s Pathways to Participation Model.

    Results: The review showed that participatory approaches were most often used in the development of interventions in school settings and in community and healthcare settings and on issues concerning support in lifestyle or in managing illness or disease. The level of participation varied from children and young people taking part just as active informants, through stages of greater participation both in quantitative and qualitative terms, to children and young people becoming an active agent involved as a co-researcher where the research process was shaped by views of a higher level of mutuality. Most of the studies were categorised at a medium level and only three studies were judged to involve the children and young people at the highest level.

    Conclusions: This scoping review showed that work remains in enabling children and young people to influence the development of interventions targeting health and well-being. In relation to level of sustainability in the interventions, it is relevant that goals, strategies and processes are formulated by those who can gain from the interventions. Participatory approaches aiming for a higher level of participation where children and young people work together with the researchers in partnerships are thus warranted. © The Author(s). 2018

  • Myhr, David (Instrumentalist, Musical director, Musician, Composer, Singer)
    Luleå University of Technology, Department of Arts, Communication and Education, Music and dance.
    Live in Swedish Radio P4 Norrbotten2018Artistic output (Unrefereed)
    Abstract [en]

    Live performance in Swedish Radio P4 Norrbotten:

    "Jealous Sun"

    "Room To Grow"

    "The Perfect Place"

  • Myhr, David (Composer, Instrumentalist, Musician, Singer, Musical director)
    Luleå University of Technology, Department of Arts, Communication and Education, Music and dance.
    Lucky Day (song)2018Artistic output (Unrefereed)
    Abstract [en]

    Please allow me to present the title track of my new album: "Lucky Day"! Co-written with the album's co-producer Brad Jones who also sings harmony and plays the beautiful bass line. You will also be able to enjoy a lovely drum take (panned right!) from the album’s other co-producer Andreas Quincy Dahlbäck, as well as a soaring pedal steel from Theo Stocks, an acoustic guitar by guitar phantom Pat Buchanan and an Billy Preston-esque organ by Rickard Nilsson.  

  • Myhr, David (Musical director, Composer, Singer, Musician, Instrumentalist)
    Luleå University of Technology, Department of Arts, Communication and Education, Music and dance.
    Lucky Day2018Artistic output (Unrefereed)
    Abstract [en]

    Lucky Day is the new album from Swedish songwriter David Myhr. Recorded with Brad Jones in Nashville, the 10 song set features co-writes with Lojinx labelmates Bleu, Bill DeMain & Young Hines, among others. Available on heavyweight 180g LP, gatefold CD and digital download with bonus tracks on the CD only.

    Jones, who has helmed notable recordings by Josh Rouse, Hayes Carll and Jill Sobule, said: “My goal was to show David branching out from youthful power-pop to a more reflective, and more lasting sound.” Comparing Lucky Day to Myhr’s prior album Soundshine, Jones continues: “The idea was to create a warmer circle of sound around David, letting him sing in an easy and natural voice, to invite the listener into his world as it is now.” Ultimately, the album offers what Jones calls “a naturalistic kind of rehearsal-room energy.“

  • Rose, Jeremy
    et al.
    University of Skövde, The Informatics Research Centre. University of Skövde, School of Informatics.
    Skiftenes Flak, Leif
    University of Agder, Kristiansand, Norway.
    Sæbø, Øystein
    University of Agder, Kristiansand, Norway.
    Stakeholder theory for the E-government context: Framing a value-oriented normative core2018In: Government Information Quarterly, ISSN 0740-624X, E-ISSN 1872-9517Article in journal (Refereed)
    Abstract [en]

    Despite substantial investments in ICT in the public sector over the past decades, it has been hard to achieve consistent benefits. One reason for the difficulties is the gap between the expectations of key stakeholders (such as governments, businesses and citizens) and project outcomes. Though normative, descriptive and instrumental aspects of stakeholder theory have been influential in explaining stakeholder interests and relationships in the management field, e-Government researchers have rather neglected the normative core of the theory. We show how value theory can improve normative foundations in this area to provide a focused analysis of four e-Government projects. We use a multiple case study approach to study the values of salient stakeholders, demonstrating how the combination of value theory and stakeholder theory provides greater explanatory power than either of the theories in isolation. Our work shows how stakeholders´ interests are bound to generic value positions and allow us to formulate implications for research and practice.

  • van Laere, Joeri
    et al.
    University of Skövde, School of Informatics. University of Skövde, The Informatics Research Centre.
    Lindblom, Jessica
    University of Skövde, School of Informatics. University of Skövde, The Informatics Research Centre.
    Cultivating a longitudinal learning process through recurring crisis management training exercises in twelve Swedish municipalities2018In: Journal of Contingencies and Crisis Management, ISSN 0966-0879, E-ISSN 1468-5973Article in journal (Refereed)
    Abstract [en]

    This study illustrates how crisis management capability is developed in series ofrecurring exercises, rather than in one single exercise. Over one hundred table-topand role-playing exercises were performed and evaluated in a longitudinal cross-caseaction research study in 12 Swedish municipalities. By consciously adapting trainingformats, municipalities were lead through three learning phases: obtaining roleunderstanding (phase 1: knowing what to do), developing information managementskills (phase 2: knowing how to do it), and mastering self-reflection in regular time-outs (phase 3: knowing when and why to do something). This final learning out-come, being able to concurrently execute, evaluate, and reorganize an ongoing crisismanagement performance, may be the most valuable capability of a crisis manage-ment organization when crisis strikes.

  • Basic, Goran
    Linnaeus University, Faculty of Social Sciences, Department of Pedagogy and Learning. Lund University, Department of Sociology.
    Konstruktion av normupplösning och moralisk panik. Etnografisk analys av underrättelse-, operativt polis- och gränsbevakningsarbete (Construction of norm resolution and moral panics. Ethnographic analysis concerning intelligence and operational police and border guards’ work)2018In: Nordic Journal of Studies in Policing, ISSN 1104-2176, E-ISSN 2242-458X, Vol. 4, no 1, p. 50-69Article in journal (Refereed)
    Abstract [en]

    The aim of the study is to analyze how intelligence and operative personnel in the Baltic Sea area describe the category “Russian criminals” and which discursive patterns cooperate with the construction of the category “norm-resolving Russian.” The analytical findings of a study are presented in the following themes: (1) Construction of norm resolution and moral panics: example criminal, (2) Construction of norm resolution and moral panics: example spy and (3) Construction of norm resolution and moral panics: example military invasion. The presentation of intelligence and operational police and border guard work as having varying morals and strengthening the argument for the need to fight against the other (“Russian”) can be interpreted in different ways. One interpretation is that constructed fear for the norm-resolving Russian and reproduced moralic panic is the expression of a social identity, and it is based on a contrast in relation to the “other”. By building up ideas about "enemies", moral panic is created and recreated, as well as the professional police and border guard professional identities. In addition, it shows in the analysis of the study the image of Russians pointed out by police and border guards in the Baltic region.

  • Li, Ying Zhen
    Study of fire and explosion hazards of alternative fuel vehicles in tunnels2018Report (Other academic)
    Abstract [en]

    An investigation of fire and explosion hazards of different types of alternativefuel vehicles in tunnels is presented. The different fuels are divided into four types:liquid fuels, liquefied fuels, compressed gases, and electricity, and detailed parameters are obtained. Three types offire hazards for the alternativefuel vehicles: pool fires, jet fires and fireballs are identified andinvestigated in detail. Fromthe perspective of pool fire size, the liquid fuels pose equivalent or evenmuch lower fire hazards compared to the traditionally used fuels, but theliquefied fuels may pose higher hazards. For pressurized tanks, the fires are generally much larger in size butshorter in duration. The gas releases from pressure relief devices and the resulting jet firesare highly transient. Forhydrogen vehicles, the fire sizes are significantly higher compared to CNGtanks, while flame lengths only slighter longer. Investigation of the peakoverpressure in case of an explosion in a tunnel was also carried out. Theresults showed that, for the vehicles investigated, the peak overpressure of tankrupture and BLEVE are mostly in a range of 0.1 to 0.36 bar at 50 m away. Thesituations in case of cloud explosion are mostly much more severe andintolerable. These hazards need to be carefully considered in both vehiclesafety design and tunnel fire safety design. Further researches on thesehazards are in urgent need.

  • Jacobsson Svärd, Staffan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Radiation Sciences.
    Håkansson, Ane
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Radiation Sciences.
    Jansson, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Radiation Sciences.
    Bäcklin, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Radiation Sciences. Uppsala University.
    Detection of Dislocated Individual Fuel Rods in a Nuclear Fuel Assembly using Tomographic Measurements1998Report (Other academic)
    Abstract [en]

    A method is suggested for identifying and quantifying possible dislocations of individual fuel rods in an irradiated nuclear fuel assembly. The method is designed for application in tomographic measurements of nuclear fuel assemblies. The source distribution of gamma radiation is reconstructed using a tomographic algorithm, in which the pixel pattern is adapted to the assembly geometry. By comparing the reconstructed source concentration in opposite parts of each fuel rod in the assembly, quantitative information may be obtained about possible dislocations.

    Theoretical considerations have been applied and data from simulations of a nuclear fuel assembly with single dislocated rods have been used in tomographic reconstructions. The investigations indicate that the method should be applicable for identification of dislocations larger than a few tenths of a mm.

  • Myhr, David (Instrumentalist, Singer, Musical director, Composer, Musician)
    Luleå University of Technology, Department of Arts, Communication and Education, Music and dance.
    "The Perfect Place"2018Artistic output (Unrefereed)
    Abstract [en]

    And so it’s time to present for the fourth track from my album Lucky Day! It’s also the second single that goes out to radio here in Sweden.

    The song is called “The Perfect Place” and was actually the first track that was recorded, before the whole project became an American adventure. This was before the co-writing trip and before the decision that Andreas Dahlbäck and I would go over to Nashville to record with Brad Jones.

  • Jacobsson Svärd, Staffan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Radiation Sciences.
    Jansson, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Radiation Sciences.
    Håkansson, Ane
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Radiation Sciences.
    Bäcklin, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Radiation Sciences. Uppsala University.
    Tomografisk bestämning av termisk effekt i kärnbränslestavar - Förstudie1996Report (Other academic)
    Abstract [sv]

    Denna rapport redovisar en förstudie av möjligheterna att med tomografisk mätning bestämma effektfördelningen i ett bränsleelement. Förstudien avses vara en första fas i en serie av tre, som, om utfallet successivt bedöms tillräckligt lovande, skall leda till en utprovad prototyp för tomografisk effektmätning.

  • Myhr, David (Composer, Musician, Musical director, Singer, Instrumentalist)
    Luleå University of Technology, Department of Arts, Communication and Education, Music and dance.
    "Jealous Sun" (single)2018Artistic output (Unrefereed)
    Abstract [en]

    The song, which is the lead track of the upcoming album is called “Jealous Sun” and is a song I wrote together with the fantastic songwriter and artist, Bleu! I had had the melody lying around for years. Actually already since before my recording session in Abbey Road. Then producer Brad Jones to my surprise suggested deleting the verse, and instead let the pre-chorus should be my verse! Brad sure knows what he’s doing. Turned out great!

  • Manzari, Luca
    et al.
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Marcus Wallenberg Laboratory MWL.
    Göransson, Peter
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Marcus Wallenberg Laboratory MWL. KTH, Superseded Departments (pre-2005), Vehicle Engineering. KTH, School of Engineering Sciences (SCI), Centres, VinnExcellence Center for ECO2 Vehicle design.
    Cuenca, Jacques
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Marcus Wallenberg Laboratory MWL.
    Lopez Arteaga, Ines
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Marcus Wallenberg Laboratory MWL. KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Vehicle Dynamics. KTH, School of Engineering Sciences (SCI), Centres, VinnExcellence Center for ECO2 Vehicle design.
    A fully automated high-speed optical rig for in vacuo, full field, non-contact vibration measurements for viscoelastic, anisotropic materials2018Conference paper (Refereed)
    Abstract [en]

    In this paper, a setup for measuring the three-dimensional displacement field of a test object un-dergoing controlled dynamic excitation in a vacuum chamber is presented. The setup has beendesigned with porous materials in mind, yet is suitable for the measurement of anisotropic vis-coelastic solids in general. To achieve non-contact data acquisition, a stereo high-speed camerasystem measures the displacement of the foundation and of the test object. A laser Doppler vi-brometer is used before the actual measurement to choose an excitation level that maximizes thesignal-to-noise ratio while allowing to ensure that the test object is fully relaxed and stable at thebeginning of every measurement. The setup, comprising both commercial and in-house hardwareand software solutions, addresses the challenges of measuring in vacuum with non-contact tech-niques. All these aspects are discussed in the current paper, and preliminary results are presented.The ultimate objective is to estimate the dynamic properties of a material using inverse methodsand the data obtained.

  • Leray, Olivier
    et al.
    Paul Scherrer Inst, Villigen, Switzerland.
    Rochman, Dimitri
    Paul Scherrer Inst, Villigen, Switzerland.
    Fleming, Michael
    United Kingdom Atom Energy Author, Abingdon, Oxon, England.
    Sublet, Jean-Christophe
    United Kingdom Atom Energy Author, Abingdon, Oxon, England.
    Koning, Arjan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics. IAEA, Nucl Data Sect, Vienna, Austria.
    Vasiliev, Alexander
    Paul Scherrer Inst, Villigen, Switzerland.
    Ferroukhi, Hakim
    Paul Scherrer Inst, Villigen, Switzerland.
    Fission yield covariances for JEFF: A Bayesian Monte Carlo method2017In: ND 2016: INTERNATIONAL CONFERENCE ON NUCLEAR DATA FOR SCIENCE AND TECHNOLOGY / [ed] Plompen, A Hambsch, FJ Schillebeeckx, P Mondelaers, W Heyse, J Kopecky, S Siegler, P Oberstedt, S, Les Ulis: EDP Sciences, 2017, article id 09023Conference paper (Refereed)
    Abstract [en]

    The JEFF library does not contain fission yield covariances, but simply best estimates and uncertainties. This situation is not unique as all libraries are facing this deficiency, firstly due to the lack of a defined format. An alternative approach is to provide a set of random fission yields, themselves reflecting covariance information. In this work, these random files are obtained combining the information from the JEFF library (fission yields and uncertainties) and the theoretical knowledge from the GEF code. Examples of this method are presented for the main actinides together with their impacts on simple burn-up and decay heat calculations.

  • Forsman, Åsa
    et al.
    Swedish National Road and Transport Research Institute, Traffic and road users, Traffic Safety and Traffic System.
    Gustafsson, Susanne
    NTF.
    Nyberg, Jonna
    Swedish National Road and Transport Research Institute, Society, environment and transport, Mobility, actors and planning processes.
    Utvärdering av alkolås efter rattfylleri: Sammanfattande slutrapport2018Report (Other academic)
    Abstract [en]

    Since January 1, 2012, there is a permanent alcohol interlock program for drink driving offenders in Sweden. The Swedish Transport Agency is responsible for the program. The interlock program has been evaluated in three studies: a register-based study, a questionnaire study, and an interview study. This final report summarizes results and conclusions from all three studies.

    The aim of the evaluation was to estimate the participation rate, but also to increase the understanding of why one chooses or does not choose to participate and to study the individual's experience of the program. The results from the studies show that:

    • The participation rate of the program was about 30 percent.
    • Both participants and non-participants in the interlock program experienced an improved health when they were asked a while after the drink driving offence and they also reported areduced alcohol consumption.
    • The largest barrier to increase the participation rate in the program is the cost, but there arealso other reasons that prevent drivers to apply.
    • Many participants experienced shortcomings in the information from the Transport Agency,both regarding the application process and regarding the mandatory parts of the program.
    • About 31 percent of the participants in the two-year program had the diagnosis alcohol abuseor alcohol dependence.
  • Uppdragsarkeologi: förfrågningsunderlag och undersökningsplan : vägledning för tillämpning av kulturmiljölagen2018Other (Other academic)
    Abstract [sv]

    Länsstyrelsens förfrågningsunderlag är uppdragsarkeologins viktigaste styrdokument. Det är också länsstyrelsens verktyg för att ange de förutsättningar som ska gälla för en undersökning. Förfrågningsunderlaget utgör även grunden för undersökningsplanen, och styr därmed indirekt kvaliteten i de uppdragsarkeologiska undersökningarna (se avsnitt 5 Bedömning av undersökare och undersökningsplan 2012). Undersökningsplanen är i sin tur ett planeringsdokument som innehåller undersökarens förslag till frågeställningar och genomförande av undersökningen. Undersökningsplanen utgör således ett underlag för länsstyrelsens beslut om undersökning och tillstånd till ingrepp i en fornlämning.

  • Uppdragsarkeologi (2 kap, 10-13§§): vägledning för tillämpning av Kulturmiljölagen : bedömning av undersökare och undersökningsplan2018Other (Other academic)
    Abstract [sv]

    Vid beslut enligt KML om en arkeologisk utredning, arkeologisk förundersökning eller arkeologisk undersökning har länsstyrelsen ansvar för att avgöra om arbetet kan förväntas bli av vetenskapligt god kvalitet.1 Att utifrån undersökningsplanen bedöma den förväntade kvaliteten på ett arbete är en komplex uppgift. Många kriterier som behöver uppfyllas kan ställas upp som krav i länsstyrelsens förfrågningsunderlag. Vissa kriterier kan bedömas med hjälp av kvantifierbara mått medan andra kriterier är föremål för en mer kvalitativ erfarenhetsbaserad bedömning. Vilka kriterier som är aktuella vid en bedömning av vad som är god kvalitet skiljer sig åt för en utredning, en förundersökning och en arkeologisk undersökning.

  • Uppdragsarkeologi: tillsyn och uppföljning : vägledning för tillämpning av kulturmiljölagen2018Report (Other academic)
    Abstract [sv]

    Tillsyn är ett begrepp som innebär att en myndighet utövar kontroll och granskning av en företeelse eller verksamhet. För uppdragsarkeologin innebär tillsyn att länsstyrelsen följer upp att villkoren i ett beslut om undersökning följs.

    Länsstyrelsen har ansvar för att en uppdragsarkeologisk undersökning genomförs med god kvalitet till en kostnad som inte är högre än motiverat. Resultaten från undersökningarna ska vara tillgängliga och användbara. Uppföljning, kontroll och granskning är metoder för länsstyrelsens tillsyn över uppdragsarkeologin. Tillsynen syftar även till att ge länsstyrelsen underlag för bedömning av kommande undersökningar när det gäller vetenskaplig inriktning, genomförande m.m. samt ge grund för lämplighetsprövningen av undersökarna.

  • Caja, Laia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    Tzavlaki, Kalliopi
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    Dadras, Mahsa Shahidi
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Tan, E-Jean
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Hatem, Gad
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    Maturi, Naga Prathyusha
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Morén, Anita
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    Wik, Lotta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Watanabe, Yukihide
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Univ Tsukuba, Dept Expt Pathol, Fac Med, Tsukuba, Ibaraki, Japan.
    Savary, Katia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Science for Life Laboratory, SciLifeLab. Univ Reims, UMR CNRS MEDyC 7369, Reims, France.
    Kamali-Moghaddam, Masood
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Uhrbom, Lene
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology.
    Heldin, Carl-Henrik
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research.
    Moustakas, Aristidis
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells2018In: Oncogene, ISSN 0950-9232, E-ISSN 1476-5594, Vol. 37, no 19, p. 2515-2531Article in journal (Refereed)
    Abstract [en]

    Glioblastoma multiforme is a brain malignancy characterized by high heterogeneity, invasiveness, and resistance to current therapies, attributes related to the occurrence of glioma stem cells (GSCs). Transforming growth factor beta (TGF beta) promotes self-renewal and bone morphogenetic protein (BMP) induces differentiation of GSCs. BMP7 induces the transcription factor Snail to promote astrocytic differentiation in GSCs and suppress tumor growth in vivo. We demonstrate that Snail represses stemness in GSCs. Snail interacts with SMAD signaling mediators, generates a positive feedback loop of BMP signaling and transcriptionally represses the TGFB1 gene, decreasing TGF beta 1 signaling activity. Exogenous TGF beta 1 counteracts Snail function in vitro, and in vivo promotes proliferation and re-expression of Nestin, confirming the importance of TGFB1 gene repression by Snail. In conclusion, novel insight highlights mechanisms whereby Snail differentially regulates the activity of the opposing BMP and TGF beta pathways, thus promoting an astrocytic fate switch and repressing stemness in GSCs.

  • Laborativa runanalyser II: svårlästa runinskrifter2018Other (Other academic)
    Abstract [sv]

    I denna rapport redogörs för undersökningar som rör svårlästa och dolda runinskrifter och som gjorts under 2012–2014 inom projektet Laborativa runanalyser, ett projekt vid Riksantikvarieämbetets Kulturvårdsavdelning.

    Syftet med projektet Laborativa runanalyser är att utforska de möjligheter som finns vid Kulturvårdslaboratoriet i Visby för att analysera runinskrifter. Vi undersöker vilka olika dokumentations- och analysmetoder som är lämpliga till vilka typer av material och objektstyper, samt vilka möjligheter och begränsningar de olika metoderna har. Vår förhoppning är att kunna utöka möjligheterna till läsning och tolkning under svåra bevarandeomständigheter. En fråga är också i vilken grad metoderna kan appliceras på svårtillgängliga platser ute i fält. I projektet ingår även pigmentanalyser av runstenar med bevarade färgspår, men dessa behandlas i en separat rapport.

  • Kälin, Gregor
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Cyclic Mario worlds - color-decomposition for one-loop QCD2018In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 4, article id 141Article in journal (Refereed)
    Abstract [en]

    We present a new color decomposition for QCD amplitudes at one-loop level as a generalization of the Del Duca-Dixon-Maltoni and Johansson-Ochirov decomposition at tree level. Starting from a minimal basis of planar primitive amplitudes we write down a color decomposition that is free of linear dependencies among appearing primitive amplitudes or color factors. The conjectured decomposition applies to any number of quark flavors and is independent of the choice of gauge group and matter representation. The results also hold for higher-dimensional or supersymmetric extensions of QCD. We provide expressions for any number of external quark-antiquark pairs and gluons. [GRAPHICS] .

  • Ladds, Marcus J. G. W.
    et al.
    Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
    Pastor-Fernandez, Andres
    Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
    Popova, Gergana
    Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
    van Leeuwen, Ingeborg M. M.
    Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
    Eng, Kai Er
    Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
    Drummond, Catherine J.
    Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
    Johansson, Lars
    Karolinska Inst, Dept Med Biochem & Biophys, Chem Biol Consortium Sweden, Div Translat Med & Chem Biol,Sci Life Lab, Stockholm, Sweden.
    Svensson, Richard
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    Westwood, Nicholas J.
    Univ St Andrews, Sch Chem & Biomed Sci, Res Complex, St Andrews, Fife, Scotland;EaStCHEM, Res Complex, St Andrews, Fife, Scotland.
    McCarthy, Anna R.
    Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
    Tholander, Fredrik
    Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.
    Popa, Mihaela
    Univ Bergen, Dept Clin Sci, Bergen, Norway.
    Lane, David P.
    Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
    McCormack, Emmet
    Univ Bergen, Dept Clin Sci, Bergen, Norway;Haukeland Hosp, Dept Internal Med, Hematol Sect, Bergen, Norway.
    McInerney, Gerald M.
    Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
    Bhatia, Ravi
    Univ Alabama Birmingham, Dept Hematol & Oncol, Birmingham, AL USA.
    Lain, Sonia
    Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
    Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib2018In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 4, article id e0195956Article in journal (Refereed)
    Abstract [en]

    Tenovin-6 is the most studied member of a family of small molecules with antitumour activity in vivo. Previously, it has been determined that part of the effects of tenovin-6 associate with its ability to inhibit SirT1 and activate p53. However, tenovin-6 has also been shown to modulate autophagic flux. Here we show that blockage of autophagic flux occurs in a variety of cell lines in response to certain tenovins, that autophagy blockage occurs regardless of the effect of tenovins on SirT1 or p53, and that this blockage is dependent on the aliphatic tertiary amine side chain of these molecules. Additionally, we evaluate the contribution of this tertiary amine to the elimination of proliferating melanoma cells in culture. We also demonstrate that the presence of the tertiary amine is sufficient to lead to death of tumour cells arrested in G1 phase following vemurafenib treatment. We conclude that blockage of autophagic flux by tenovins is necessary to eliminate melanoma cells that survive B-Raf inhibition and achieve total tumour cell kill and that autophagy blockage can be achieved at a lower concentration than by chloroquine. This observation is of great relevance as relapse and resistance are frequently observed in cancer patients treated with B-Raf inhibitors.

  • Vadeby, Anna
    et al.
    Swedish National Road and Transport Research Institute, Traffic and road users, Traffic Safety and Traffic System.
    Forsman, Åsa
    Swedish National Road and Transport Research Institute, Traffic and road users, Traffic Safety and Traffic System.
    Sörensen, Gunilla
    Swedish National Road and Transport Research Institute, Traffic and road users, Traffic Safety and Traffic System.
    Utvärdering av intensiferad hastighetsövervakning i Polisregion Väst2018Report (Other academic)
    Abstract [en]

    The aim of the present study is to evaluate the new methods for increased speed compliance. Both the police's experience, as well as internal and external communication as effects on mean speeds and speed violations are studied. Police in the western region tested a new method during three autumn weeks in 2016.

    The intervention entailed intensified speed enforcement on 13 designated routes and the aim was to reduce mean speed. The intervention focused on three different actions:

    • short manual speed controls (20 minutes) on roads with high speeds and a high accident record
    • civil police cars (so-called pilot cars) focusing on aggressive driving
    • monitoring with mobile speed cameras as a complement to the manual speed controls.

    According to the police’s experiences, the results show that most policemen involved were positive to the intervention overall. It was appreciated that traffic issues appeared on the agenda and the Police received a positive response from the citizens. Basically, they experienced that the 20-minutes method was a good way of working which leads to increased visibility of the Police. The effort also led to more controls than what would have been done otherwise, which was considered as important by the police. Suggestions for improvements are that local police men should be more involved in the selection of roads for enforcement and it was suggested to have several shorter interventions instead of one long.

  • Kuhn, Jose Manuel Monroy
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology.
    Jakobsson, Mattias
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Human Evolution.
    Günther, Torsten
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Human Evolution.
    Estimating genetic kin relationships in prehistoric populations2018In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 4, article id e0195491Article in journal (Refereed)
    Abstract [en]

    Archaeogenomic research has proven to be a valuable tool to trace migrations of historic and prehistoric individuals and groups, whereas relationships within a group or burial site have not been investigated to a large extent. Knowing the genetic kinship of historic and prehistoric individuals would give important insights into social structures of ancient and historic cultures. Most archaeogenetic research concerning kinship has been restricted to uniparental markers, while studies using genome-wide information were mainly focused on comparisons between populations. Applications which infer the degree of relationship based on modern-day DNA information typically require diploid genotype data. Low concentration of endogenous DNA, fragmentation and other post-mortem damage to ancient DNA (aDNA) makes the application of such tools unfeasible for most archaeological samples. To infer family relationships for degraded samples, we developed the software READ (Relationship Estimation from Ancient DNA). We show that our heuristic approach can successfully infer up to second degree relationships with as little as 0.1x shotgun coverage per genome for pairs of individuals. We uncover previously unknown relationships among prehistoric individuals by applying READ to published aDNA data from several human remains excavated from different cultural contexts. In particular, we find a group of five closely related males from the same Corded Ware culture site in modern-day Germany, suggesting patrilocality, which highlights the possibility to uncover social structures of ancient populations by applying READ to genome-wide aDNA data. READ is publicly available from https://bitbucket.org/tguenther/read.

  • Blesneag, Stefan
    et al.
    Univ Oxford, Rudolf Peierls Ctr Theoret Phys, 1 Keble Rd, Oxford OX1 3NP, England.
    Buchbinder, Evgeny I.
    Univ Western Australia, Dept Phys M013, 35 Stirling Highway, Crawley, WA 6009, Australia.
    Constantin, Andrei
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Lukas, Andre
    Univ Oxford, Rudolf Peierls Ctr Theoret Phys, 1 Keble Rd, Oxford OX1 3NP, England.
    Palti, Eran
    Werner Heisenberg Inst, Max Planck Inst Phys, Fohringer Ring 6, D-80805 Munich, Germany.
    Matter field Kahler metric in heterotic string theory from localisation2018In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 4, article id 139Article in journal (Refereed)
    Abstract [en]

    We propose an analytic method to calculate the matter field Kahler metric in heterotic compactifications on smooth Calabi-Yau three-folds with Abelian internal gauge fields. The matter field Kahler metric determines the normalisations of the N = 1 chiral superfields, which enter the computation of the physical Yukawa couplings. We first derive the general formula for this Kahler metric by a dimensional reduction of the relevant supergravity theory and find that its T-moduli dependence can be determined in general. It turns out that, due to large internal gauge flux, the remaining integrals localise around certain points on the compactification manifold and can, hence, be calculated approximately without precise knowledge of the Ricci-flat Calabi-Yau metric. In a final step, we show how this local result can be expressed in terms of the global moduli of the Calabi-Yau manifold. The method is illustrated for the family of Calabi-Yau hypersurfaces embedded in P-1 x P-3 and we obtain an explicit result for the matter field Kahler metric in this case.

  • Leppaaho, Tanja
    et al.
    Lappeenranta Univ Technol, Sch Business & Management, Lappeenranta, Finland;Univ Jyvaskyla, Sch Business & Econ, Jyvaskyla, Finland.
    Chetty, Sylvie
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies. Univ Otago, Dept Mkt, Otago Business Sch, Dunedin, New Zealand.
    Dimitratos, Pavlos
    Univ Glasgow, ASBS, Glasgow, Lanark, Scotland.
    Network embeddedness in the internationalization of biotechnology entrepreneurs2018In: Entrepreneurship and Regional Development, ISSN 0898-5626, E-ISSN 1464-5114, Vol. 30, no 5-6, p. 562-584Article in journal (Refereed)
    Abstract [en]

    This study investigates how entrepreneurs of biotech enterprises embed in domestic and international networks so as to internationalize. We advance a contextual framework of embeddedness of internationalizing entrepreneurs, providing a contribution (i) by synthesizing and applying existing conceptual insights from the networking literature to provide a more culturally sensitive view of getting embedded for international entrepreneurship in the biotech industry and (ii) by adding insights into the practices and (micro)processes of how and in what ways embeddedness integrates with the internationalization of biotech entrepreneurs. Our study involves six entrepreneurs from Canada, Finland, and New Zealand. Context-specific embeddedness was studied by exploring the (i) type, (ii) strength, (iii) locality, and (iv) importance of the international and national network ties among internationalizing entrepreneurs. We found differences in relation to the locality of universities and research institutes, role and type of financiers, and customer focus in internationalization. For instance, while customers were central to the embeddedness of Canadian and New Zealand entrepreneurs, Finnish entrepreneurs had no focus on their customers, but acted solely through sales channels and partners. The customer focus of New Zealand entrepreneurs was mainly international, whereas it was domestic in the case of Canadian entrepreneurs.

  • Liu, Jingyi
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
    Ma'ayeh, Showgy Y.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
    Peirasmaki, Dimitra
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
    Lundstrom-Stadelmann, Britta
    Univ Bern, Vetsuisse Fac, Inst Parasitol, Bern, Switzerland.
    Hellman, Lars
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
    Svärd, Staffan G.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology.
    Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines2018In: Virulence, ISSN 2150-5594, E-ISSN 2150-5608, Vol. 9, no 1, p. 879-894Article in journal (Refereed)
    Abstract [en]

    Giardiasis is a common diarrheal disease caused by the protozoan parasite Giardia intestinalis. Cysteine proteases (CPs) are acknowledged as virulence factors in Giardia but their specific role in the molecular pathogenesis of disease is not known. Herein, we aimed to characterize the three main secreted CPs (CP14019, CP16160 and CP16779), which were identified by mass spectrometry in the medium during interaction with intestinal epithelial cells (IECs) in vitro. First, the CPs were epitope-tagged and localized to the endoplasmic reticulum and cytoplasmic vesicle-like structures. Second, we showed that recombinant CPs, expressed in Pichia pastoris, are more active in acidic environment (pH 5.5-6) and we determined the kinetic parameters using fluorogenic substrates. Third, excretory-secretory proteins (ESPs) from Giardia trophozoites affect the localization of apical junctional complex (AJC) proteins and recombinant CPs cleave or re-localize the AJC proteins (claudin-1 and -4, occludin, JAM-1, beta-catenin and E-cadherin) of IECs. Finally, we showed that the ESPs and recombinant CPs can degrade several chemokines, including CXCL1, CXCL2, CXCL3, IL-8, CCL2, and CCL20, which are up-regulated in IECs during Giardia-host cell interactions. This is the first study that characterizes the role of specific CPs secreted from Giardia and our results collectively indicate their roles in the disruption of the intestinal epithelial barrier and modulating immune responses during Giardia infections.

  • Olaison, Anna
    et al.
    Linkoping Univ, Dept Social & Welf Studies, Linkoping, Sweden.
    Torres, Sandra
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Sociology.
    Forssell, Emilia
    Ersta Skondal Bracke Univ Coll, Dept Social Sci, Stockholm, Sweden.
    Professional discretion and length of work experience: what findings from focus groups with care managers in elder care suggest2018In: Journal of Social Work Practice, ISSN 0265-0533, E-ISSN 1465-3885, Vol. 32, no 2, p. 153-167Article in journal (Refereed)
    Abstract [en]

    Research has explored how care managers in elder care - who often function as street-level bureaucrats' - regard professional discretion. The way in which length of work experience affects care managers' use of professional discretion remains, however, unexplored. This article present findings from 12 focus groups with 60 care managers. By bringing attention to how care managers experience the needs assessment process, this article sheds light on how these street-level bureaucrats' struggle when they try to balance their clients' needs against institutional frameworks and local guidelines. Length of work experience seems to play a role in how care managers claim to use professional discretion. Experienced care managers describe how they deviate from the guidelines at times in order to create an increased scope of action in their decision-making process. Those with less time in the profession describe greater difficulties in this respect. Findings suggest that research should explore if length of work experience plays a role in the actual way in which care managers assess needs and make decisions. As such, they contribute to our understanding of how needs assessment processes are navigated by professionals while also pointing towards the nature of professional discretion in gerontological social work.

  • Carlson, A. D.
    et al.
    NIST, Gaithersburg, MD USA.
    Pronyaev, V.
    Rosatom State Corp, Atomsrandart, Moscow, Russia.
    Hale, G. M.
    Los Alamos Natl Lab, Los Alamos, NM USA.
    Zhenpeng, C.
    Tsinghua Univ, Beijing, Peoples R China.
    Capote, R.
    IAEA, NAPC Nucl Data Sect, Vienna, Austria.
    Duran, I.
    Univ Santiago de Compostela, Fac Fis, La Coruna, Spain.
    Hambsch, F. -J
    EC JRC Dir G, Geel, Belgium.
    Kawano, T.
    Los Alamos Natl Lab, Los Alamos, NM USA.
    Kunieda, S.
    Japan Atom Energy Agcy, Nucl Data Ctr, Tokai, Ibaraki, Japan.
    Mannhart, W.
    Phys Tech Bundesanstalt, Neutron Metrol Grp, Braunschweig, Germany.
    Marcinkevicius, Benjaminas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics. IAEA, NAPC Nucl Data Sect, Vienna, Austria.
    Nelson, R. O.
    Los Alamos Natl Lab, Los Alamos, NM USA.
    Neudecker, D.
    Los Alamos Natl Lab, Los Alamos, NM USA.
    Noguere, G.
    CEA Cadarache, SPRC/LEPh, St Paul Les Durance, France.
    Paris, M.
    Los Alamos Natl Lab, Los Alamos, NM USA.
    Schillebeeckx, P.
    EC JRC Dir G, Unit G2, Geel, Belgium.
    Simakov, S.
    IAEA, NAPC Nucl Data Sect, Vienna, Austria; Karlsruhe Inst Technol, Eggenstein Leopoldshafen, Germany.
    Smith, D. L.
    Argonne Associate Seville, Coronado, CA USA.
    Talou, P.
    Los Alamos Natl Lab, Los Alamos, NM USA.
    Tao, X.
    China Inst Atom Energy, CNDC, Beijing, Peoples R China.
    Trkov, A.
    IAEA, NAPC Nucl Data Sect, Vienna, Austria.
    Wallner, A.
    Australian Natl Univ, Res Sch Phys & Engn, Nucl Phys, Canberra, ACT, Australia.
    A new evaluation of the neutron data standards2017In: ND 2016: INTERNATIONAL CONFERENCE ON NUCLEAR DATA FOR SCIENCE AND TECHNOLOGY / [ed] Plompen, A Hambsch, FJ Schillebeeckx, P Mondelaers, W Heyse, J Kopecky, S Siegler, P Oberstedt, S, EDP Sciences, 2017, article id 02025Conference paper (Refereed)
    Abstract [en]

    Evaluations are being done for the H(n,n), 6Li(n,t), 10B(n,αγ), 10B(n,α), C(n,n), Au(n,γ), 235U(n,f) and 238U(n,f) standard cross sections. Evaluations are also being done for data that are not traditional standards including: the Au(n,γ) cross section at energies below where it is considered a standard; reference cross sections for prompt gamma-ray production in fast neutron-induced reactions; reference cross sections for very high energy fission cross sections; the 235U thermal neutron fission spectrum and the 252Cf spontaneous fission neutron spectrum and the thermal constants.

  • Johansson, Karin
    et al.
    Region Kronoberg.
    Almerud Österberg, Sofia
    Linnaeus University.
    Leksell, Janeth
    University Dalarna / Uppsala University.
    Berglund, Mia
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Supporting patients learning to live with diabetes: a phenomenological study2018In: British Journal of Nursing, ISSN 0966-0461, E-ISSN 2052-2819, Vol. 27, no 12, p. 697-704Article in journal (Refereed)
    Abstract [en]

    This article describes a study of the phenomenon of supporting patients who are learning to live with diabetes, from a diabetes specialist nurse (DSN) perspective. Guided by principles of reflective lifeworld research, data from six interviews (four in groups and two individual) with 16 DSNs were analysed. The results show that, in order to support learning, DSNs use a self-critical approach with the insight that they should not take over responsibility for their patients’ diabetes. The DSNs support, encourage and challenge the patients to self-reflect and take responsibility based on patients’ own goals and needs. To provide support, DSNs need to assume a tactful, critically challenging approach, dare to confront patients’ fears and other emotions and have the insight to know that the responsibility for learning and integration of the condition lies with the patient. To be able to support patients in this way, it is necessary that the DSN is mentored and supported in this role.

  • Karthikesalingam, A.
    et al.
    St Georges Univ London, St Georges Vasc Inst, London, England;St Georges Univ London, Mol & Clin Sci Res Inst, London, England.
    Grima, M. J.
    St Georges Univ London, St Georges Vasc Inst, London, England;St Georges Univ London, Mol & Clin Sci Res Inst, London, England.
    Holt, P. J.
    St Georges Univ London, St Georges Vasc Inst, London, England;St Georges Univ London, Mol & Clin Sci Res Inst, London, England.
    Vidal-Diez, A.
    St Georges Univ London, St Georges Vasc Inst, London, England;St Georges Univ London, Populat Hlth Res Inst, London, England.
    Thompson, M. M.
    St Georges Univ London, St Georges Vasc Inst, London, England.
    Wanhainen, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Björck, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Mani, Kevin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Comparative analysis of the outcomes of elective abdominal aortic aneurysm repair in England and Sweden2018In: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 105, no 5, p. 520-528Article in journal (Refereed)
    Abstract [en]

    Background

    There is substantial international variation in mortality after abdominal aortic aneurysm (AAA) repair; many non-operative factors influence risk-adjusted outcomes. This study compared 90-day and 5-year mortality for patients undergoing elective AAA repair in England and Sweden.

    Methods

    Patients were identified from English Hospital Episode Statistics and the Swedish Vascular Registry between 2003 and 2012. Ninety-day mortality and 5-year survival were compared after adjustment for age and sex. Separate within-country analyses were performed to examine the impact of co-morbidity, hospital teaching status and hospital annual caseload.

    Results

    The study included 36 249 patients who had AAA treatment in England, with a median age of 74 (i.q.r. 69–79) years, of whom 87·2 per cent were men. There were 7806 patients treated for AAA in Sweden, with a median of age 73 (68–78) years, of whom 82·9 per cent were men. Ninety‐day mortality rates were poorer in England than in Sweden (5·0 versus 3·9 per cent respectively; P < 0·001), but were not significantly different after 2007. Five‐year survival was poorer in England (70·5 versus 72·8 per cent; P < 0·001). Use of EVAR was initially lower in England, but surpassed that in Sweden after 2010. In both countries, poor outcome was associated with increased age. In England, institutions with higher operative annual volume had lower mortality rates.

    Conclusion

    Mortality for elective AAA repair was initially poorer in England than Sweden, but improved over time alongside greater uptake of EVAR, and now there is no difference. Centres performing a greater proportion of EVAR procedures achieved better results in England. Improving in England

  • Grünloh, Christiane
    KTH, School of Electrical Engineering and Computer Science (EECS).
    Using technological frames as an analytic tool in value sensitive design2018In: Ethics and Information Technology, ISSN 1388-1957, E-ISSN 1572-8439Article in journal (Refereed)
    Abstract [en]

    This article proposes the use of technological frames (TF) as an analytical tool to support the investigations within value sensitive design. TF can help to identify values that are consistent or conflicting within and between stakeholders, which is exemplified with a case of patient accessible electronic health records in Sweden. The article concludes that TF can help to identify values, which may then help to understand and address possible concerns in the design process.

  • Bengtsson, Fia
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution.
    Rydin, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution.
    Hajek, Tomas
    Univ South Bohemia, Dept Expt Plant Biol, Fac Sci, Branisovska 1760, CZ-37005 Ceske Budejovice, Czech Republic;Czech Acad Sci, Inst Bot, Dept Funct Ecol, Dukelska 135, CZ-37982 Trebon, Czech Republic.
    Biochemical determinants of litter quality in 15 species of Sphagnum2018In: Plant and Soil, ISSN 0032-079X, E-ISSN 1573-5036, Vol. 425, no 1-2, p. 161-176Article in journal (Refereed)
    Abstract [en]

    Background and aims Sphagnum mosses are ecosystem engineers that create and maintain boreal peatlands. With unique biochemistry, waterlogging and acidifying capacities, they build up meters-thick layers of peat, reducing competition and impeding decomposition. We quantify within-genus differences in biochemical composition to make inferences about decay rates, related to hummock-hollow and fen-bog gradients and to phylogeny. Methods We sampled litter from 15 Sphagnum species, abundant over the whole northern hemisphere. We used regression and Principal Components Analysis (PCA) to evaluate general relationships between litter quality parameters and decay rates measured under laboratory and field conditions. Results Both concentrations of the polysaccharide sphagnan and the soluble phenolics were positively correlated with intrinsic decay resistance, however, so were the previously understudied lignin-like phenolics. More resistant litter had more of all the important metabolites; consequently, PC1 scores were related to lab mass loss (R-2 = 0.57). There was no such relationship with field mass loss, which is also affected by the environment. PCA also revealed that metabolites clearly group Sphagnum sections (subgenera). Conclusions We suggest that the commonly stated growth-decomposition trade-off is largely due to litter quality. We show a strong phylogenetic control on Sphagnum metabolites, but their effects on decay are affected by nutrient availability in the habitat.

  • Rahatulain, Afifa
    et al.
    KTH, School of Industrial Engineering and Management (ITM), Production Engineering, Production Systems.
    Onori, Mauro
    KTH, School of Industrial Engineering and Management (ITM), Production Engineering, Production Systems.
    Viewpoints and views for the architecture description of cyber-physical manufacturing systems2018Conference paper (Refereed)
    Abstract [en]

    A well-defined architecture covering all the views, viewpoints and related stakeholders’ concerns throughout the life cycle is vital for a good system design. This becomes even more crucial when designing Cyber Physical Manufacturing Systems (CPMS), one of the key elements in factories of the future. This paper identifies views and viewpoints necessary for defining architecture for CPMS. A mapping between system stakeholders, concerns and viewpoints is also presented. The results shall serve as a basis for an architecture-centric development methodology for CPMS as well as conventional manufacturing systems.

  • Saketi, Sara
    et al.
    Dalarna University, School of Technology and Business Studies, Materials Technology. Uppsala University.
    Bexell, Ulf
    Dalarna University, School of Technology and Business Studies, Materials Technology.
    Olsson, Mikael
    Dalarna University, School of Technology and Business Studies, Materials Technology. Uppsala University.
    Wear mechanism of cemented carbide cutting tool in the turning of 316L stainless steel2018Conference paper (Refereed)
  • Swenberg, Thorbjörn
    Dalarna University, School of Humanities and Media Studies, Moving Image Production.
    Complex design data joined in audiovisual representation: Benefits and issues in analysis2018In: PIN-C Conference Proceedings 2018, Eskilstuna, 2018, p. 319-323Conference paper (Refereed)
    Abstract [en]

    Participatory methods in design or innovationresearch can require several different kinds of datain order to cover the object or process of interest tothe study. This paper addresses the potential anddifficulties of joining and analyzing several datacategories into a unified observational video, whereall data is represented in either audio, visual oraudiovisual form. The core problem of such acomplex body of data is that the analysis requiresefficient tools and/or methods to match the datacomplexity. The current case regards a participatorystudy on film editing, its method and datacomplexity, and discusses analytical approaches.

  • Adetula, Victor
    The Nordic Africa Institute, Research Unit.
    The future of EU-Africa cooperation beyond the Cotonou agreement2018Report (Other academic)
    Abstract [en]

    There is profound concern in large circles in Africa that the Cotonou Agreement obstructs African governments from supporting domestic production, and that the EU is splitting Africa in two by striking separate deals with different African regions. These perceptions are important considerations for those involved in the upcoming negotiations to replace the existing agreement.

  • Eriksson, Per Erik
    et al.
    Dalarna University, School of Humanities and Media Studies, Moving Image Production.
    Swenberg, Thorbjörn
    Dalarna University, School of Humanities and Media Studies, Moving Image Production.
    Zhao, Xiaoyun
    Dalarna University, School of Technology and Business Studies, Microdata Analysis.
    Eriksson, Yvonne
    Mälardalens Högskola / IPR.
    How gaze time on screen impacts the efficacy of visual instructions2018In: Heliyon, ISSN 2405-8440, Vol. 4, no 6, article id e00660Article in journal (Refereed)
    Abstract [en]

    This article explores whether GTS (gaze time on screen) can be useful as an engagement measure in the screen mediated learning context. Research that exemplifies ways of measuring engagement in the on-line education context usually does not address engagement metrics and engagement evaluation methods that are unique to the diverse contemporary instructional media landscape. Nevertheless, unambiguous construct definitions of engagement and standardized engagement evaluation methods are needed to leverage instructional media's efficacy. By analyzing the results from a mixed methods eye-tracking study of fifty-seven participants evaluating their visual and assembly performance levels in relation to three visual, procedural instructions that are versions of the same procedural instruction, we found that the mean GTS-values in each group were rather similar. However, the original GTS-values outputted from the ET-computer were not entirely correct and needed to be manually checked and cross validated. Thus, GTS appears not to be a reliable, universally applicable automatic engagement measure in screen-based instructional efforts. Still, we could establish that the overall performance of learners was somewhat negatively impacted by lower than mean GTS-scores, when checking the performance levels of the entire group (N = 57). When checking the stimuli groups individually (N = 17, 20, 20), the structural diagram group's assembly time durations were positively influenced by higher than mean GTS-scores.

  • Helsingforsavtalet: Samarbetsöverenskommelse mellan Danmark, Finland, Island, Norge och Sverige2018Other (Other (popular science, discussion, etc.))
    Abstract [sv]

    Helsingforsavtalet – samarbetsöverenskommelse mellan Danmark, Finland, Island, Norge och Sverige. Avtalet undertecknades den 23 mars 1962 och trädde i kraft den 1 juli samma år. Den ursprungliga texten har reviderats genom överenskommelser som undertecknats den 13 februari 1971, den 11 mars 1974, den 15 juni 1983, den 6 maj 1985, den 21 augusti 1991, den 18 mars 1993 och den 29 september 1995. De senaste ändringarna trädde i kraft den 2 januari 1996.