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  • Edman, Johan
    Stockholm University, Faculty of Social Sciences, Centre for Social Research on Alcohol and Drugs (SoRAD).
    A qualitative analysis of Pål Kraft2017In: Nordic Studies on Alcohol and Drugs, ISSN 1455-0725, E-ISSN 1458-6126, Vol. 34, no 3Article in journal (Refereed)
  • Edman, Johan
    et al.
    Stockholm University, Faculty of Social Sciences, Centre for Social Research on Alcohol and Drugs (SoRAD).
    Helmersson Bergmark, Karin
    Stockholm University, Faculty of Social Sciences, Department of Sociology.
    Scholars’ open debate paper on the World Health Organization ICD-11 Gaming Disorder proposal2017In: Journal of Behavioral Addictions, ISSN 2062-5871, E-ISSN 2063-5303, Vol. 6, no 3Article in journal (Refereed)
  • Praagh, Martijn van
    et al.
    Hartman, Cornelia
    Brandmyr, Emma
    Microplastics in Landfill Leachates in the Nordic Countries2018Book (Other academic)
    Abstract [en]

    This report summarizes results from sampling and analysis of microplastics in leachates from a total of 11 landfills in Finland, Iceland and Norway. The study was commissioned by the Nordic Waste Group (NAG) and the Marine Group (HAV) under the Nordic Council of Ministers. Polymer particles with an upper size limit of 5 mm and a lower limit of 50 μm (micrometres), were included. Samples were analysed by FT-IR spectroscopy. Most samples tested positive for multiple microplastics. Compared to other quantified sources of microplastics such as raw or treated sewage, landfill leachates are likely to be a relatively small source of microplastic particles between 5000 and 50 µm. Variations in particle count extends, however, over several orders of magnitude. Variability and potential effects of microplastics in landfill leachates, including particles <50µm, should be focus of future studies.

  • Tadesse Abate, Molla
    et al.
    University of Borås, Faculty of Textiles, Engineering and Business.
    Nierstrasz, Vincent
    University of Borås, Faculty of Textiles, Engineering and Business.
    Combined Pre-treatment and Causticization of cotton fabric for improved dye uptake2017In: Advance Research in Textile Engineering, ISSN 2572-9373, Vol. 2, no 1, article id 1016Article in journal (Refereed)
    Abstract [en]

    Conventionally, cotton fabric is subjected to a series of separate pretreatment processes such as desizing, scouring, and bleaching to remove natural and added impurities for satisfactory dyeing and finishing. When the sole purpose is to improve the dye uptake, cotton fabric is subjected to yet another separate process called causticization, a treatment of cotton fabric at reduced concentration of caustic soda (110-150 g/L) compared to mercerization. All these processes i.e. desizing, scouring, and bleaching are lengthy and require large amount of water, energy, chemicals, and time which lead to increase in cost and productivity loss.

    In this paper, a combined desizing, scouring, bleaching and causticization process with shorter processing time is reported. Single factor randomized experimental design was used for process optimization. Based on experiments, the optimum recipe consisted of padding the gray cotton fabric using a twodip, two-nip technique in a bath containing NaOH 140g/L; Sodium Per Borate (SPB) 40-45g/L; wetting agent 1g/L, batching for 30 min at room temperature and washing the treated fabric with 1g/L emulsifier twice for 15 minutes each at boil with 3% owf SPB added during the second wash, rinsed with hot and cold water and air dried.

    The results showed excellent wettability, good degree of whiteness, minimum loss of tensile strength and higher dye uptake compared to uncausticized commercially bleached cotton fabric.

  • Pöppel, Ludmila
    et al.
    Stockholm University, Faculty of Humanities, Department of Slavic and Baltic Studies, Finnish, Dutch, and German, Slavic Languages.
    Dobrovol'skij, Dmitrij
    Stockholm University, Faculty of Humanities, Department of Slavic and Baltic Studies, Finnish, Dutch, and German, Slavic Languages.
    Корпусное исследование квазисинонимичных конструкций возьми и Vimp. vs. взял и V3pers2018In: Anuari de Filologia. Llengües i Literatures Modernes (ANU.FILOL.LLENG.LIT.MOD.), E-ISSN 2014-1394, no 8, p. 115-131Article in journal (Refereed)
    Abstract [ru]

    В статье рассматриваются квазисинонимичные конструкции возьми и Vimp vs. взял и V3pers и их варианты. В основе этих конструкций лежит общий паттерн [взять CONJco V], то есть «глагол взять в разных грамматических формах + сочинительный союз + основной глагол вразных грамматических формах». Заполнение слота CONJco допускает лишь три варианта:и, да и да и, в то время как слот V кажется на первый взгляд практически свободным. Задача исследования – выявить семантические предпочтения в выборе глагола, заполняющего свободный слот каждой из сопоставляемых конструкций. В частности, показано, что различие между этими конструкциями связано с семантическим признаком ‘контролируемости действия’.

  • Koutsopoulos, Georgios
    Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
    Modeling Organizational Potentials Using the Dynamic Nature of Capabilities2018In: Joint Proceedings of the BIR 2018 Short Papers, Workshops and Doctoral Consortium co-located with 17th International Conference Perspectives in Business Informatics Research (BIR 2018), Jelena Zdravkovic, Jānis Grabis, Selmin Nurcan, Janis Stirna , 2018, p. 387-398Conference paper (Refereed)
    Abstract [en]

    Organizational transformation in dynamic environments may be addressed using an approach based on the concept of capability. The aim of this thesis project is to tackle existing disadvantages that organizations are unaware of or missing business opportunities due to unoptimized design. Design Science is employed to elicit requirements and develop a method that assists the identification of desired organizational capabilities and outdated capabilities. This will enhance the value generating and supporting capabilities by introducing a new typology and exploring the factors affecting the introduced capability types. The developed artifact will also be supported by a modeling tool using the ADOxx metamodeling development platform and tested in a real use case.

  • Johannesson, Paul
    et al.
    Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
    Andersson, Birger
    Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
    Ascribing Value2018In: Proceedings of the 12th International Workshop on Value Modeling and Business Ontologies / [ed] Jaap Gordijn, Erik Proper, Jaap Gordijn, Erik Proper , 2018, p. 28-36Conference paper (Refereed)
  • McGrath, Cormac
    et al.
    Stockholm University, Faculty of Social Sciences, Department of Education.
    Nilsonne, Gustav
    Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet.
    Data sharing in qualitative research: opportunities and concerns2018In: MedEdPublish, ISSN 2312–7996, Vol. 7, no 4, article id 34Article in journal (Refereed)
    Abstract [en]

    Data sharing is increasingly practiced by researchers and mandated by research funders as well as scientific journals. However, data sharing within qualitative research paradigms is less common, and sharing interview data has particular challenges. Earlier debate has pointed to the value of data sharing for discouraging research fraud and permitting critical scrutiny. We elaborate on this discussion by highlighting the value of data sharing for cumulative science, for re-use, and to maximise the value of the participants’ contribution. We review methods and possibilities for sharing interview data, and give concrete recommendations for mitigating risks to the participants. In conclusion, we find that sharing of interview data is possible, valuable, and ethical, and serves a purpose for both journals and researchers.

  • Gao, Jiangning
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Sundström, Görel
    Swedish Univ Agr Sci, Dept Forest Genet & Plant Physiol, Umea, Sweden.
    Moghadam, Behrooz Torabi
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Zamani, Neda
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Grabherr, Manfred
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    ACES: a machine learning toolbox for clustering analysis and visualization2018In: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 19, article id 964Article in journal (Refereed)
    Abstract [en]

    Background: Studies that aim at explaining phenotypes or disease susceptibility by genetic or epigenetic variants often rely on clustering methods to stratify individuals or samples. While statistical associations may point at increased risk for certain parts of the population, the ultimate goal is to make precise predictions for each individual. This necessitates tools that allow for the rapid inspection of each data point, in particular to find explanations for outliers.

    Results: ACES is an integrative cluster- and phenotype-browser, which implements standard clustering methods, as well as multiple visualization methods in which all sample information can be displayed quickly. In addition, ACES can automatically mine a list of phenotypes for cluster enrichment, whereby the number of clusters and their boundaries are estimated by a novel method. For visual data browsing, ACES provides a 2D or 3D PCA or Heat Map view. ACES is implemented in Java, with a focus on a user-friendly, interactive, graphical interface.

    Conclusions: ACES has been proven an invaluable tool for analyzing large, pre-filtered DNA methylation data sets and RNA-Sequencing data, due to its ease to link molecular markers to complex phenotypes. The source code is available from https://github.com/GrabherrGroup/ACES.

  • Mayega, R. W.
    et al.
    Makerere Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Coll Hlth Sci, POB 7072, Kampala, Uganda.
    Ekirapa, E.
    Makerere Univ, Sch Publ Hlth, Dept Hlth Policy Planning & Management, Coll Hlth Sci, Kampala, Uganda.
    Kirunda, B.
    Makerere Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Coll Hlth Sci, POB 7072, Kampala, Uganda.
    Nalwadda, C.
    Makerere Univ, Sch Publ Hlth, Dept Community Hlth & Behav Sci, Coll Hlth Sci, Kampala, Uganda.
    Aweko, J.
    Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
    Tomson, G.
    Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden;Karolinska Inst, Dept Learning Informat Management & Eth LIME, Stockholm, Sweden;Royal Swedish Acad Sci, SIGHT, Stockholm, Sweden.
    Ostenson, C. G.
    Makerere Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Coll Hlth Sci, POB 7072, Kampala, Uganda.
    Van Olmen, J.
    Inst Trop Med, Antwerp, Belgium.
    Daivadanam, Meena
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Food, Nutrition and Dietetics. Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
    Kiguli, J.
    Makerere Univ, Sch Publ Hlth, Dept Community Hlth & Behav Sci, Coll Hlth Sci, Kampala, Uganda.
    'What kind of life is this?' Diabetes related notions of wellbeing among adults in eastern Uganda and implications for mitigating future chronic disease risk2018In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 18, article id 1409Article in journal (Refereed)
    Abstract [en]

    Background: Effective prevention and care for type 2 diabetes requires that people link healthy behaviours to chronic disease-related wellbeing. This study explored how people perceive current and future wellbeing, so as to inform lifestyle education.

    Methods: Eight focus group discussions and 12 in-depth interviews were conducted in Iganga and Mayuge districts in rural Eastern Uganda among people aged 35-60years in three risk categories (1) People with diabetes, (2) people at higher risk of diabetes (with hypertension or overweight) and (3) community members without diabetes.

    Results: People define wellbeing in three notions: 1) Physical health, 2) Socio-economic status and 3) Aspirational fulfilment. Most people hold the narrower view of wellbeing that focuses on absence of pain. Most overweight participants did not feel their condition as affecting their wellbeing. However, for several people with hypertension, the pains they describe indicate probable serious heart disease. Some people with diabetes expressed deep worry and loss of hope, saying that thoughts are more bothersome than the illness'. Wellbeing among people with diabetes was described in two perspectives: Those who view diabetes as a static' condition think that they cannot attain wellbeing while those who view it as a dynamic' condition think that with consistent treatment and healthy lifestyles, they can be well. While many participants perceive future wellbeing as important, people without diabetes are less concerned about it than those with diabetes. Inadequate knowledge about diabetes, drug stock-outs in health facilities, unaffordable healthier food, and contradictory information were cited as barriers to future wellbeing in people with diabetes.

    Conclusions: To make type 2 diabetes prevention relevant to healthy people, health education messages should link current lifestyles to future wellbeing. Diabetes patients need counselling support, akin to that in HIV care, to address deep worry and loss of hope.

  • Hjern, Anders
    Stockholm University, Faculty of Social Sciences, Department of Public Health Sciences. Karolinska Institutet, Sweden.
    Health of refugee and migrant children: Technical guidance2018Report (Other academic)
    Abstract [en]

    Around one million asylum-seeking children were registered in the European Union(EU) during 2015–2017, of whom 200 000 (one in five) arrived unaccompanied by acaregiver. This technical guidance focuses on the initial response of the health careservices to the needs of these and other refugee and migrant children.All countries in the WHO European Region have signed and ratified the United Nation’sConvention on the Rights on the Child (CRC) and have agreed to the obligationscontained in this. This technical guidance identifies a number of areas where the healthsituation for migrant children would be improved if countries adhered more closely tothese obligations.Medical care for chronic disorders and rehabilitation for disabilities are often themost pressing needs of migrant children, with needs for dental care being the mostcommon. In addition, migrant children from low- and middle-income countries have ahigher burden of chronic infectious disorders compared with those from high-incomecountries, and these disorders need to be identified and treated. Lack of access topreventive health care in the countries of origin make vaccination programmes a highpriority to prevent outbreaks of measles and other vaccine-preventable disorders.To address mental health needs, a holistic and family-oriented public health strategyfor promoting mental health and psychological well-being is needed. This shouldinclude collaboration between many different sectors of society, with education inschools and pre-schools being particularly important. There is some evidence alsoto support the effectiveness of more specific interventions to promote well-being, forexample psychoeducational approaches to cope with psychological trauma, culturallysensitive parent-support programmes and interventions in the school environment.A general finding in the literature is that differences in health status between childrenin different migrant groups are greater than the differences between migrant childrenand local populations in Europe. Country of origin is an important predictor here, butalso the social background of the family in the country of origin and the living conditionsin the destination country. Consequently, health assessment/screening proceduresshould be individualized. A comprehensive individualized health assessment by apaediatric nurse or clinician, preferably as soon as possible after the child arrivesin the country of destination, can identify health care needs that might otherwisego undetected for prolonged periods of time. It also allows screening for potentiallycommunicable disorders and updating of vaccinations. Such an approach would savecosts by coordinating health care use in an informed manner. The provision of medicalinterpreters and cultural mediators is important to make care provision for migrantchildren more equitable with that for the host population.

    The evidence presented in this technical guidance is primarily based on observationalreports and theory, plus individual evaluative studies. This reflects the lack of evaluativeresearch of policy and specific interventions on how to facilitate health, well-beingand positive development in migrant children in Europe. There are large knowledgegaps in research regarding pathways to resilience and for assessing the impact ofspecific interventions that may be likely to be effective in improving outcomes. Longterm follow-up is required to evaluate interventions intended to enhance well-being,educational outcomes, employment and social inclusion. Close collaboration withpolicy-makers and key service providers is essential to ensure optimal translation offindings into sustainable practice.

  • Martinsson, Dennis
    Stockholm University, Faculty of Law, Department of Law.
    På nödfronten något nytt?: Reflektioner om nöd i ljuset av NJA 2017 s. 8722018In: Juridisk Publikation, ISSN 2000-2920, no 2, p. 311-328Article in journal (Refereed)
  • Ivarsson, Andreas
    et al.
    Högskolan i Halmstad.
    Stenling, Andreas
    Umeå Universitet.
    Lundkvist, Erik
    Swedish School of Sport and Health Sciences, GIH, Department of Sport and Health Sciences, Sport Psychology research group.
    "Mirror, mirror, on the wall is there any evidence at all?”: Critical reflections on evidence in sport psychology research2017In: Idrottsforskaren, no 2, p. 35-40Article in journal (Other (popular science, discussion, etc.))
    Abstract [en]

    Two common objectives in sport and exercise psychology research are to determinate if there is a relationship between two or more variables or if an intervention is effective or not (i.e., casual effects). Based on results obtained from a research study we are often eager to conclude that there are strong (or weak) evidence for the proposed relationship or intervention. This procedure might seem straightforward but there are several problems and critical issues that influence researcher’s assessments of the level of evidence. Unfortunately many researchers in the sport and exercise psychology field does not acknowledge these problems and critical issues when interpreting study results, which leads to flawed conclusions about the level of evidence (Ivarsson & Andersen, 2016). In this article we will: (a) highlight what we believe are some of the most critical issues in the sport and exercise psychology field for assessing the level of evidence, and (b) provide suggestions for how to deal with these issues.

  • Dorn, Michael
    et al.
    Linnaeus University, Faculty of Technology, Department of Building Technology.
    Tuvendal, Helena
    Södra skogsägarna.
    Henrik, Oxfall
    Swerea.
    Serrano, Erik
    Lunds Tekniska Högskola.
    FBBB 4.3 Biobaserade skivmaterial: Experimentella undersökningar2018Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    Rapporten är del av projektet Framtidens Byggande och Boende (FBBB), delprojekt 4.3 "Biobaserade skivmaterial". I denna rapport presenteras resultatet av de mekaniska drag- och böjprov såsom DTMA analys. Materialet ”Durapulp”, som tillverkas av Södra, är referensmaterialet i delprojektet. Provkroppar av Durapulp producerades med olika tillverkningsmetoder för att se skillnader i beteenden. Referensmaterialen är trä-baserade skivmaterial som anses vanligt förekommande i byggskeendet.

  • Peterson, Elin
    Stockholm University, Faculty of Social Sciences, Department of Social Work.
    Struggles for Recognition and Redistribution: Family Carers and Domestic Workers in Spanish Eldercare2018In: International Journal of Care and Caring, ISSN 2397-8821, Vol. 2, no 4, p. 459-476Article in journal (Refereed)
    Abstract [en]

    Theories of social justice have identified the revaluation of caregiving work as a global challenge. Still, struggles for recognition are shaped by the specific cultural and institutional contexts in which they emerge. This article explores struggles for the recognition of caregiving work in Spanish eldercare, focusing on advocacy for family carers and for domestic workers. Drawing on interviews, findings reveal that domestic workers' needs are politicised to a greater extent than family carers' needs; empowerment and claims for workers' rights contrast with notions of self-care and mutual support. While the struggles are differentiated, the undervaluation of eldercare is a common theme.

  • Rattenborg, Rune
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Configuring Mesopotamia: Regional Signifiers and the Many Locations of the ‘Land Between the Rivers’2018In: Mapping Ancient Identities: Methodisch-kritische Reflexionen zu Kartierungspraktiken / [ed] Susanne Grunwald, Kerstin P. Hofmann, Daniel A. Werning, Felix Wiedemann, Berlin: Edition Topoi, 2018, p. 147-166Chapter in book (Refereed)
    Abstract [de]

    Es mag überflüssig erscheinen, sich erneut mit der genauen Bedeutung des Begriffs ‚Mesopotamien‘ zu befassen. Die auf der Hand liegende Bedeutung der griechischen Wörter mésos (‚mitten‘, ‚zwischen‘) und potamós (‚Strom‘, ‚Fluss‘) verhindert meist eine nähere Beschäftigung mit dem Ursprung und der vermeintlich offensichtlichen heutigen Verwendung des Wortes ‚Mesopotamien‘. Doch regionale Begriffe sind nicht statisch. Sie werden nicht nur durch physische Grenzlinien definiert, sondern vielfältige Merkmale. Ich untersuche hier die wechselnden Bedeutungen des Begriffs ‚Mesopotamien‘ für das Einzugsgebiet von Euphrat und Tigris vom 2. Jahrtausend v. Chr. bis heute und komme zu dem Ergebnis, dass die heutige Vorstellung von ‚Mesopotamien‘ in der Zeit des Ersten Weltkriegs entstanden ist und damit nur wenig zu tun hat mit neutralen Quellenhinweisen auf die ferne Vergangenheit.

  • Morin, Andreanne
    et al.
    McGill Univ, Dept Human Genet, Montreal, PQ, Canada;McGill Univ, Montreal, PQ, Canada;Genome Quebec Innovat Ctr, Montreal, PQ, Canada;Univ Quebec Chicoutimi, Dept Sci Fondamentales, Saguenay, PQ, Canada.
    Madore, Anne-Marie
    Univ Quebec Chicoutimi, Dept Sci Fondamentales, Saguenay, PQ, Canada.
    Kwan, Tony
    McGill Univ, Dept Human Genet, Montreal, PQ, Canada;McGill Univ, Montreal, PQ, Canada;Genome Quebec Innovat Ctr, Montreal, PQ, Canada.
    Ban, Maria
    Univ Cambridge, Dept Clin Neurosci, Cambridge, England.
    Partanen, Jukka
    Finnish Red Cross Blood Serv, Res & Dev, Helsinki, Finland.
    Rönnblom, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
    Syvänen, Ann-Christine
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Sawcer, Stephen
    Univ Cambridge, Dept Clin Neurosci, Cambridge, England.
    Stunnenberg, Hendrik
    Radboud Univ Nijmegen, Dept Mol Biol, Fac Sci, Nijmegen, Netherlands.
    Lathrop, Mark
    McGill Univ, Dept Human Genet, Montreal, PQ, Canada;McGill Univ, Montreal, PQ, Canada;Genome Quebec Innovat Ctr, Montreal, PQ, Canada.
    Pastinen, Tomi
    McGill Univ, Dept Human Genet, Montreal, PQ, Canada;McGill Univ, Montreal, PQ, Canada;Genome Quebec Innovat Ctr, Montreal, PQ, Canada;Ctr Pediat Genom Med, Kansas City, MO USA.
    Laprise, Catherine
    Univ Quebec Chicoutimi, Dept Sci Fondamentales, Saguenay, PQ, Canada;Ctr Integre Univ Sante & Serv Sociaux Saguenay La, Saguenay, PQ, Canada.
    Exploring rare and low-frequency variants in the Saguenay-Lac-Saint-Jean population identified genes associated with asthma and allergy traits2019In: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 27, no 1, p. 90-101Article in journal (Refereed)
    Abstract [en]

    The Saguenay-Lac-Saint-Jean (SLSJ) region is located in northeastern Quebec and is known for its unique demographic history and founder effect. As founder populations are enriched with population-specific variants, we characterized the variants distribution in SLSJ and compared it with four European populations (Finnish, Sweden, United Kingdom and France), of which the Finnish population is another founder population. Targeted sequencing of the coding and non-coding immune regulatory regions of the SLSJ asthma familial cohort and the four European populations were performed. Rare and low-frequency coding and non-coding regulatory variants identified in the SLSJ population were then investigated for variant-and gene-level associations with asthma and allergy-related traits (eosinophil percentage, immunoglobulin (Ig) E levels and lung function). Our data showed that (1) rare or deleterious variants were not enriched in the two founder populations as compared with the three non-founder European populations; (2) a larger proportion of founder population-specific variants occurred with higher frequencies; and (3) low-frequency variants appeared to be more deleterious. Furthermore, a rare variant, rs1386931, located in the 3'-UTR of CXCR6 and intron of FYCO1 was found to be associated with eosinophil percentage. Gene-based analyses identified NRP2, MRPL44 and SERPINE2 to be associated with various asthma and allergy-related traits. Our study demonstrated the usefulness of using a founder population to identify new genes associated with asthma and allergy-related traits; thus better understand the genes and pathways implicated in pathophysiology.

  • Benesperi, Iacopo
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry. Uppsala Univ, Dept Chem, Angstrom Lab, S-75120 Uppsala, Sweden.
    Michaels, Hannes
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Freitag, Marina
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    The researcher's guide to solid-state dye-sensitized solar cells2018In: Journal of Materials Chemistry C, ISSN 2050-7526, E-ISSN 2050-7534, Vol. 6, no 44, p. 11903-11942Article, review/survey (Refereed)
    Abstract [en]

    In order to sustainably support its ever-increasing energy demand, the human society will have to harvest renewable energy wherever and whenever possible. When converting light to electricity, silicon solar cells are the technology of choice to harvest direct sunlight due to their high performance and continuously dropping price. For diffused light and indoor applications, however, silicon is not the material of choice. To power the next gizmo in your smart home, dye-sensitized solar cells (DSCs) are a viable alternative. Made from inexpensive, earth-abundant, and non-toxic materials, DSCs perform best at low light intensity. So far, issues such as leakage of the liquid electrolyte and its corrosive nature have limited the commercialization of this technology. To overcome these limitations, solid-state DSCs (ssDSCs) - in which the liquid electrolyte is replaced by a solid material - have been developed. For many years their efficiencies have been poor, preventing them from being widely employed. In the past six years, however, research efforts have led them to rival with their liquid counterparts. Here, we will review recent advancements in the field of ssDSCs. Every device component will be acknowledged, from metal oxides and new dyes to novel hole transporters, dopants, counter-electrodes and device architectures. After reviewing materials, long-term stability of devices will be addressed, finally giving an insight into the future that awaits this exciting technology.

  • Lind, Johan
    Stockholm University, Faculty of Humanities, Department of Archaeology and Classical Studies, Centre for Cultural Evolution.
    What can associative learning do for planning?2018In: Royal Society Open Science, E-ISSN 2054-5703, Vol. 5, no 11, article id 180778Article in journal (Refereed)
    Abstract [en]

    There is a new associative learning paradox. The power of associative learning for producing flexible behaviour in non-human animals is downplayed or ignored by researchers in animal cognition, whereas artificial intelligence research shows that associative learning models can beat humans in chess. One phenomenon in which associative learning often is ruled out as an explanation for animal behaviour is flexible planning. However, planning studies have been criticized and questions have been raised regarding both methodological validity and interpretations of results. Due to the power of associative learning and the uncertainty of what causes planning behaviour in non-human animals, I explored what associative learning can do for planning. A previously published sequence learning model which combines Pavlovian and instrumental conditioning was used to simulate two planning studies, namely Mulcahy & Call 2006 'Apes save tools for future use.' Science 312, 1038-1040 and Kabadayi & Osvath 2017 'Ravens parallel great apes in flexible planning for tool-use and bartering. 'Science 357, 202-204. Simulations show that behaviour matching current definitions of flexible planning can emerge through associative learning. Through conditioned reinforcement, the learning model gives rise to planning behaviour by learning that a behaviour towards a current stimulus will produce high value food at a later stage; it can make decisions about future states not within current sensory scope. The simulations tracked key patterns both between and within studies. It is concluded that one cannot rule out that these studies of flexible planning in apes and corvids can be completely accounted for by associative learning. Future empirical studies of flexible planning in non-human animals can benefit from theoretical developments within artificial intelligence and animal learning.

  • Tokimatsu, Koji
    et al.
    Tokyo Inst Technol, Midori Ku, 4259 Nagatsuta, Yokohama, Kanagawa 2268503, Japan;Natl Inst Adv Ind Sci & Technol, 1-1-1 Higashi, Tsukuba, Ibaraki 3058567, Japan.
    McLellan, Benjamin
    Kyoto Univ, Grad Sch Energy Sci, Sakyo Ku, Yoshida Honmachi, Kyoto 6068501, Japan.
    Höök, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Natural Resources and Sustainable Development.
    Murakami, Shinsuke
    Univ Tokyo, Sch Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan.
    Yasuoka, Rieko
    Syst Res Ctr Co Ltd, Minato Ku, KY Bldg,3-16-7, Tokyo 1050001, Japan.
    Nishio, Masahiro
    Natl Inst Adv Ind Sci & Technol, 1-1-1 Higashi, Tsukuba, Ibaraki 3058567, Japan.
    Energy modeling approach to the global energy-mineral nexus: A case of fuel cell vehicle2017In: PROCEEDINGS OF THE 9TH INTERNATIONAL CONFERENCE ON APPLIED ENERGY / [ed] Yan, J Wu, J Li, H, ELSEVIER SCIENCE BV , 2017, p. 2361-2364Conference paper (Refereed)
    Abstract [en]

    Hydrogen draw great attentions to become center of the Japanese energy policy after succeeding rapid expansion of renewable energy and dash for gas, after the Fukushima daiichi nuclear accident. This study estimates the metal requirement for hydrogen technologies by using a cost-minimizing energy model on the global energy-mineral nexus. The models are consisted from production of resources, land use and land use changes, inter-regional transportation, energy conversion (power, liquid fuels, gas), production of materials, final demand, wood products, disposal of used products, and materials recycling. Two energy and climate scenarios were developed to represent primarily economic efficiency and environmental performance, respectively, under climate policies with 2DC target, and without any constraints. Based on the future hydrogen consumption, metal requirements and cumulative production were estimated, to compare with production levels in 2015 and reserves. Candidates of hydrogen technologies are, fuel cells (for vehicle, stationary), storage tanks, and production, utilizing sectors in transport, power, and heat. (C) 2017 The Authors. Published by Elsevier Ltd. Peer-review under responsibility of the scientific committee of the 9th International Conference on Applied Energy.

  • Westin, Lars
    et al.
    Umeå University, Faculty of Social Sciences, Department of Economics.
    Johansson, Börje
    Grassini, Maurisio
    Estimation of capital matrices for multisectoral models: an application to Italy and Tuscany1982Report (Other academic)
  • Liang, Feiyan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Lindberg, Pia
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Lindblad, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Engineering photoautotrophic carbon fixation for enhanced growth and productivity2018In: Sustainable Energy & Fuels, ISSN 2398-4902, Vol. 2, no 12, p. 2583-2600Article, review/survey (Refereed)
    Abstract [en]

    Oxygenic photosynthesis is the origin of most organic carbon compounds on Earth and an essential part of the natural carbon cycle. Cyanobacteria, the only oxygenic photoautotrophic prokaryotes, are important in several natural processes: as primary sustainable producers, in providing oxygen to the atmosphere, and in nitrogen fixation. From a biotechnological perspective, cyanobacteria are ideal cell factories since (i) the required energy and carbon source, sunlight and CO2, are abundant and freely available, (ii) cyanobacteria are capable of producing a variety of natural products, which can be used as fuels, medicines, cosmetics etc., and (iii) metabolic engineering and synthetic biology tools of cyanobacteria are being developed rapidly, making them feasible as host organisms for heterologous production of interesting compounds. However, compared to commercially employed heterotrophic microorganisms, the growth and productivity of cyanobacteria are currently not competitive. Therefore, improving cyanobacterial growth and productivity is an important task to enable commercialization of cyanobacterial bioproducts. Such studies also offer important clues for increasing the photosynthesis and yield of crop plants, which is important in view of providing food for a rapidly increasing world population. There are many strategies targeting this task, such as optimizing cultivation conditions, engineering native pathways, and introducing synthetic pathways based on an understanding of overall metabolic networks. One major limitation of cyanobacterial productivity, however, is the low efficiency of carbon fixation through the Calvin-Benson-Bassham (CBB) cycle. In this review, we introduce and discuss the possibilities to enhance growth and productivity by engineering the CBB cycle. We also give a brief discussion of options to further extend the capabilities of cells to fix inorganic carbon by the introduction of other native and artificial carbon fixation cycles.

  • Collins, Elin
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology.
    Strandell, Annika
    Granåsen, Gabriel
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Idahl, Annika
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology.
    Menopausal symptoms and surgical complications after opportunistic bilateral salpingectomy, a register-based cohort study2019In: American Journal of Obstetrics and Gynecology, ISSN 0002-9378, E-ISSN 1097-6868, Vol. 220, no 1, article id 85.e1-e10Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: In recent years, the fallopian tubes have been found to play a critical role in the pathogenesis of ovarian cancer. Therefore, bilateral salpingectomy at the time of hysterectomy has been proposed as a preventive procedure, but with scarce scientific evidence to support the efficiency and safety. OBJECTIVE: Our primary objective was to evaluate the risk of surgical complications and menopausal symptoms when performing bilateral salpingectomy in addition to benign hysterectomy. Furthermore, we sought to compare time in surgery, perioperative blood loss/blood transfusion, duration of hospital stay, days to normal activities of daily living, and days out of work for hysterectomy with bilateral salpingectomy compared with hysterectomy only. A secondary objective was to study the uptake of opportunistic salpingectomy in Sweden. STUDY DESIGN: This was a retrospective observational cohort study based on data from the National Quality Register of Gynecological Surgery in Sweden. Women <55 years of age who had a hysterectomy for benign indications with or without bilateral salpingectomy in 1998 through 2016 were included. Possible confounding was adjusted for in multivariable regression models. RESULTS: During the study period, 23,369 women had a hysterectomy for benign indications. The frequency of bilateral salpingectomy at the time of hysterectomy increased mainly from 2013, which is why the period 2013 through mid-2016 was selected for further analysis (n = 6892). There was a low frequency of vaginal hysterectomy with bilateral salpingectomy performed in this period, which is why only abdominal and laparoscopic surgeries were selected for comparative analysis (n = 4906). This study indicates an increased risk of menopausal symptoms (adjusted relative risk, 1.33; 95% confidence interval, 1.04-1.69) 1 year after hysterectomy with bilateral salpingectomy compared with hysterectomy only. Hospital stay was 0.1 days longer in women having salpingectomy (P = .01), and bleeding was slightly reduced in the salpingectomy group (-20 mL, P = .04). Other outcome measures were not significantly associated with salpingectomy, albeit a tendency toward higher risk of minor complications was seen (adjusted relative risk, 1.30; 95% confidence interval, 0.93-1.83). CONCLUSION: Bilateral salpingectomy at the time of hysterectomy was associated with an increased risk of menopausal symptoms 1 year after surgery. Randomized clinical trials reducing the risk of residual and unmeasured confounding and longer follow-up are needed to correctly inform women on the risks and benefits of opportunistic salpingectomy.

  • Gambadauro, Pietro
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetrics and Reproductive Health Research. Karolinska Inst, Dept Learning Informat Management & Eth LIME, Natl Ctr Suicide Res & Prevent Mental Hlth NASP 3, S-17177 Stockholm, Sweden;Res Med Sweden, Gynaecol & Reprod Med, S-75224 Uppsala, Sweden.
    Carli, Vladimir
    Karolinska Inst, Dept Learning Informat Management & Eth LIME, Natl Ctr Suicide Res & Prevent Mental Hlth NASP 3, S-17177 Stockholm, Sweden.
    Wasserman, Camilla
    Karolinska Inst, Dept Learning Informat Management & Eth LIME, Natl Ctr Suicide Res & Prevent Mental Hlth NASP 3, S-17177 Stockholm, Sweden;Columbia Univ, New York State Psychiat Inst, Dept Child & Adolescent Psychiat, New York, NY USA.
    Hadlaczky, Gergo
    Karolinska Inst, Dept Learning Informat Management & Eth LIME, Natl Ctr Suicide Res & Prevent Mental Hlth NASP 3, S-17177 Stockholm, Sweden.
    Sarchiapone, Marco
    Univ Molise, Dept Med & Hlth Sci, I-86100 Campobasso, Italy;Natl Inst Hlth Migrat & Poverty, Via San Gallicano 25-A, I-00100 Rome, Italy.
    Apter, Alan
    Tel Aviv Univ, Schneider Childrens Med Ctr Israel, Tel Aviv, Israel.
    Balazs, Judit
    Vadaskert Child Psychiat Hosp & Outpatient Clin, H-1021 Budapest, Hungary;Eotvos Lorand Univ, Inst Psychol, Izabella U 46, H-1064 Budapest, Hungary.
    Bobes, Julio
    Univ Oviedo, CIBERSAM Sch Med, Dept Psychiat, Julian Claveria 6-3, E-33006 Oviedo, Spain.
    Brunner, Romuald
    Heidelberg Univ, Ctr Psychosocial Med, Dept Child & Adolescent Psychiat, Blumenstr 8, D-69115 Heidelberg, Germany.
    Cosman, Doina
    Iuliu Hatieganu Univ Med & Pharm, Clin Psychol Dept, Cluj Napoca, Romania.
    Haring, Christian
    State Hosp Hall Tyrol, Tirol Kliniken, Dept Psychiat & Psychotherapy B, Milser Str 10, A-6060 Hall In Tirol, Austria.
    Hoven, Christina W.
    Columbia Univ, New York State Psychiat Inst, Dept Child & Adolescent Psychiat, New York, NY USA;Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA.
    Iosue, Miriam
    Univ Molise, Dept Med & Hlth Sci, I-86100 Campobasso, Italy.
    Kaess, Michael
    Heidelberg Univ, Ctr Psychosocial Med, Dept Child & Adolescent Psychiat, Blumenstr 8, D-69115 Heidelberg, Germany.
    Kahn, Jean Pierre
    Univ Lorraine, CHRU Nancy, Dept Psychiat & Clin Psychol, Nancy, France;Univ Lorraine, Ctr Psychotherap Nancy Laxou, Pole 6, Nancy, France.
    McMahon, Elaine
    Univ Coll Cork, Natl Suicide Res Fdn, Cork, Ireland.
    Postuvan, Vita
    Univ Primorska, Andrej Marus Inst, Slovene Ctr Suicide Res, Muzejski Trg 2, Koper 6000, Slovenia.
    Varnik, Airi
    Tallinn Univ, Ctr Behav & Hlth, Estonian Swedish Mental Hlth & Suicidol Inst, Tallinn, Estonia.
    Wasserman, Danuta
    Karolinska Inst, Dept Learning Informat Management & Eth LIME, Natl Ctr Suicide Res & Prevent Mental Hlth NASP 3, S-17177 Stockholm, Sweden.
    Psychopathology is associated with reproductive health risk in European adolescents2018In: Reproductive Health, ISSN 1742-4755, E-ISSN 1742-4755, Vol. 15, article id 186Article in journal (Refereed)
    Abstract [en]

    BackgroundReproductive and mental health are key domains of adolescent wellbeing but possible interrelationships are poorly understood. This cross-sectional study evaluated the association between psychopathology and reproductive health risk among European adolescents.MethodsA structured self-report questionnaire was delivered to 12,395 pupils of 179 randomly selected schools in 11 European countries within the EU funded Saving and Empowering Young Lives in Europe (SEYLE) project. The questionnaire included items about sexual initiation and reproductive health risk factors, such as number of sexual partners, frequency of condom use, and pregnancy involvement. Psychopathology was evaluated with validated instruments and/or ad-hoc questions.ResultsOf 11,406 respondents (median age 15; interquartile range [IQR] 14-15; 57% females), 18.8% reported sexual initiation. Sixty percent of them also reported at least one reproductive risk factor. Sexual initiation was significantly more common among pupils older than 15years (38% versus 13.2% younger pupils) and males (21.3% versus 16.9% females). It was also more common among pupils with depression (age/sex-adjusted odds ratio [aOR] 1.871), anxiety (aOR 2.190), severe suicidal ideation (aOR 2.259), self-injurious behaviour (aOR 2.892), and suicide attempts (aOR 3.091). These associations were particularly strong among pupils 15years old and, for overt psychopathology, among pupils with low non-sexual risk behaviour profile and females. Depression (aOR 1.937), anxiety (aOR 2.282), severe suicidal ideation (aOR 2.354), self-injurious behaviour (aOR 3.022), and suicide attempts (aOR 3.284) were associated with higher reproductive health risk, defined by an increasing number of coexisting reproductive risk factors.ConclusionsThese findings suggest an alignment between mental and reproductive health risk and support the value of cross-domain collaboration in adolescent health. The association between psychopathology and reproductive health risk, as well as its variations with age, sex, and associated risk behaviours, should be considered when designing health-promoting or disease-preventing interventions for adolescents.

  • Berkesand, Peter
    Linköping University, University Library.
    Teknisk utvärdering av elektroniska publiceringsplattformar2003Report (Other academic)
    Abstract [sv]

    I samband med universitetets utredning Universitetets informationsförsörjning tillsattes resursgrupper. En av dessa grupper var tekniska gruppen som fick i uppgift att se över vilka publiceringssystem som finns.

    Gruppen har undersökt vilka publiceringsplattformar tillgängliga för elektronisk publicering av vetenskapliga publikationer som kan vara intressanta för E-press. Inom gruppen har diskussioner förts kring de olika plattformarna.

    Vid studiebesök och egna tester framstår för närvarande DiVA som det mest genomarbetade systemet för elektronisk publicering. Vi får ett helt igenom färdigt publiceringssystem som går att använda efter några justeringar för att anpassa det till våra behov.

    Både EPrints och DSpace bör utvärderas mer. I synnerhet DSpace som inte ännu används i Sverige. Eventuellt kommer både DSpace och EPrints att installeras och utvärderas närmare under hösten 2003.

  • Hall, Matthew
    et al.
    Ulster University, UK.
    Hearn, Jeff
    Hanken School of Economics, Helsinki, Finland.
    Violation by sexual image distribution, “revenge pornography”, cyberabuses, and prevention2018In: 6th International Report. Crime Prevention and Community Safety: Preventing Cybercrime / [ed] Pablo Madriaza, Montreal, Canada: International Centre for the Prevention of Crime (ICPC) , 2018, p. 103-110Chapter in book (Other academic)
  • Hearn, Jeff
    University of Huddersfield, Huddersfield, UK.
    Panel record progress2018In: Network, Vol. 130, p. 38-38Article in journal (Other (popular science, discussion, etc.))
  • Hearn, Jeff
    et al.
    Örebro University, School of Humanities, Education and Social Sciences. University of Huddersfield, Huddersfield, UK; Hanken School of Economics, Helsinki, Finland.
    Hall, Matthew
    University of Ulster, UK; University of Derby, UK.
    “This is my cheating ex”: Gender and sexuality in revenge porn2018In: Sexualities, ISSN 1363-4607, E-ISSN 1461-7382, p. 1-23Article in journal (Refereed)
    Abstract [en]

    Revenge pornography is the online, and at times offline, non-consensual distribution, or sharing, of explicit images by ex-partners, partners, others, or hackers seeking revenge or entertainment. In this article, we discursively analyse a selected range of electronic written texts accompanying explicit images posted by self-identified straight/gay/lesbian (male-to-female, female-to-male, male-to-male, female-to-female postings) on a popular revenge pornography website ‘MyEx.com’. Situating our analysis in debates on gender and sexuality, we examine commonalities and differences in the complex and sometimes contradictory ways in which gender and sexuality are invoked in posters’ accounts of their motivations for revenge pornography.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P. O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Search for resonant W Z production in the fully leptonic final state in proton-proton collisions at root s=13 TeV with the ATLAS detector2018In: Physics Letters B, ISSN 0370-2693, E-ISSN 1873-2445, Vol. 787, p. 68-88Article in journal (Refereed)
    Abstract [en]

    A search for a heavy resonance decaying into WZ in the fully leptonic channel (electrons and muons) is performed. It is based on proton-proton collision data collected by the ATLAS experiment at the Large Hadron Collider at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 36.1 fb(-1). No significant excess is observed over the Standard Model predictions and limits are set on the production cross section times branching ratio of a heavy vector particle produced either in quark-antiquark fusion or through vector-boson fusion. Constraints are also obtained on the mass and couplings of a singly charged Higgs boson, in the Georgi-Machacek model, produced through vector-boson fusion. (C) 2018 The Author(s). Published by Elsevier B.V.

  • Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Different perspectives on outcomes in patients with non-ST-elevation myocardial infarction when observed in clinical trials and in real life2018In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 39, no 42, p. 3821-3824Article in journal (Other academic)
  • Ahlers, Markus
    et al.
    Univ Copenhagen, Niels Bohr Inst, Niels Bohr Int Acad, DK-2100 Copenhagen, Denmark;Univ Copenhagen, Niels Bohr Inst, Discovery Ctr, DK-2100 Copenhagen, Denmark.
    Helbing, Klaus
    Univ Wuppertal, Dept Phys, D-42119 Wuppertal, Germany.
    de los Heros, Carlos
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Probing particle physics with IceCube2018In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 78, no 11, article id 924Article, review/survey (Refereed)
    Abstract [en]

    The IceCube observatory located at the South Pole is a cubic-kilometre optical Cherenkov telescope primarily designed for the detection of high-energy astrophysical neutrinos. IceCube became fully operational in 2010, after a seven-year construction phase, and reached a milestone in 2013 by the first observation of cosmic neutrinos in the TeV-PeV energy range. This observation does not only mark an important breakthrough in neutrino astronomy, but it also provides a new probe of particle physics related to neutrino production, mixing, and interaction. In this review we give an overview of the various possibilities how IceCube can address fundamental questions related to the phenomena of neutrino oscillations and interactions, the origin of dark matter, and the existence of exotic relic particles, like monopoles. We will summarize recent results and highlight future avenues.

  • Lagarde, N.
    et al.
    Univ Bourgogne Franche Comte, OSU THETA Franche Comte Bourgogne, Observ Besancon, Inst UTINAM,CNRS,UMR 6213, BP 1615, F-25010 Besancon, France.
    Reyle, C.
    Univ Bourgogne Franche Comte, OSU THETA Franche Comte Bourgogne, Observ Besancon, Inst UTINAM,CNRS,UMR 6213, BP 1615, F-25010 Besancon, France.
    Robin, A. C.
    Univ Bourgogne Franche Comte, OSU THETA Franche Comte Bourgogne, Observ Besancon, Inst UTINAM,CNRS,UMR 6213, BP 1615, F-25010 Besancon, France.
    Tautvaisiene, G.
    Vilnius Univ, Inst Theoret Phys & Astron, Sauletekio Av 3, LT-10257 Vilnius, Lithuania.
    Drazdauskas, A.
    Vilnius Univ, Inst Theoret Phys & Astron, Sauletekio Av 3, LT-10257 Vilnius, Lithuania.
    Mikolaitis, S.
    Vilnius Univ, Inst Theoret Phys & Astron, Sauletekio Av 3, LT-10257 Vilnius, Lithuania.
    Minkeviciute, R.
    Vilnius Univ, Inst Theoret Phys & Astron, Sauletekio Av 3, LT-10257 Vilnius, Lithuania.
    Stonkute, E.
    Vilnius Univ, Inst Theoret Phys & Astron, Sauletekio Av 3, LT-10257 Vilnius, Lithuania.
    Chorniy, Y.
    Vilnius Univ, Inst Theoret Phys & Astron, Sauletekio Av 3, LT-10257 Vilnius, Lithuania.
    Bagdonas, V.
    Vilnius Univ, Inst Theoret Phys & Astron, Sauletekio Av 3, LT-10257 Vilnius, Lithuania.
    Miglio, A.
    Univ Birmingham, Sch Phys & Astron, Birmingham B15 2TT, W Midlands, England.
    Nasello, G.
    Univ Bourgogne Franche Comte, OSU THETA Franche Comte Bourgogne, Observ Besancon, Inst UTINAM,CNRS,UMR 6213, BP 1615, F-25010 Besancon, France.
    Gilmore, G.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England.
    Randich, S.
    Osserv Astrofis Arcetri, INAF, Largo E Fermi 5, I-50125 Florence, Italy.
    Bensby, T.
    Lund Observ, Dept Astron & Theoret Phys, Box 43, S-22100 Lund, Sweden.
    Bragaglia, A.
    Osservatorio Astron Bologna, INAF, Via Gobetti 93-3, I-40129 Bologna, Italy.
    Flaccomio, E.
    Osserv Astron Palermo, INAF, Piazza Parlamento 1, I-90134 Palermo, Italy.
    Francois, P.
    Univ Paris Diderot, CNRS, Observ Paris, GEPI, 5 Pl Jules Janssen, F-92190 Meudon, France.
    Korn, Andreas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy.
    Pancino, E.
    Osserv Astrofis Arcetri, INAF, Largo E Fermi 5, I-50125 Florence, Italy;Agenzia Spaziale Italiana, Space Sci Data Ctr, Via Politecn, I-00133 Rome, Italy.
    Smiljanic, R.
    Polish Acad Sci, Nicolaus Copernicus Astron Ctr, Ul Bartycka 18, PL-00716 Warsaw, Poland.
    Bayo, A.
    Univ Valparaiso, Inst Fis & Astron, Valparaiso, Chile.
    Carraro, G.
    Univ Padua, Dipartimento Fis & Astron, Vicolo Osservatorio 3, I-35122 Padua, Italy.
    Costado, M. T.
    Univ Cadiz, Dept Didact, Puerto Real 11519, Cadiz, Spain.
    Jimenez-Esteban, F.
    CSIC, INTA, Ctr Astrobiol, Dept Astrofis, ESAC Campus,Camino Bajo Castillo S-N, Madrid 28692, Spain;Suffolk Univ, Madrid Campus,C Vina 3, Madrid 28003, Spain.
    Jofre, P.
    Univ Diego Port, Fac Ingn, Nucleo Astron, Av Ejercito 441, Santiago, Chile.
    Martell, S. L.
    Univ New South Wales, Sch Phys, Sydney, NSW 2052, Australia.
    Masseron, T.
    Inst Astrofis Canarias, Tenerife 38205, Spain;Univ La Laguna, Dept Astrofis, E-38206 Tenerife, Spain.
    Monaco, L.
    Univ Andres Bello, Dept Ciencias Fis, Fernandez Concha 700, Santiago, Chile.
    Morbidelli, L.
    Osserv Astrofis Arcetri, INAF, Largo E Fermi 5, I-50125 Florence, Italy.
    Sbordone, L.
    European Southern Observ, Alonso Cordova 3107, Santiago, Chile.
    Sousa, S. G.
    Univ Porto, CAUP, Inst Astrofis & Ciencias Espaco, Rua Estrelas, P-4150762 Porto, Portugal.
    Zaggia, S.
    Padova Observ, INAF, Vicolo Osservatorio 5, I-35122 Padua, Italy.
    The Gaia-ESO Survey: impact of extra mixing on C and N abundances of giant stars2018In: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 621, article id A24Article in journal (Refereed)
    Abstract [en]

    Context: The Gaia-ESO Public Spectroscopic Survey using FLAMES at the VLT has obtained high-resolution UVES spectra for a large number of giant stars, allowing a determination of the abundances of the key chemical elements carbon and nitrogen at their surface. The surface abundances of these chemical species are known to change in stars during their evolution on the red giant branch (RGB) after the first dredge-up episode, as a result of the extra mixing phenomena.

    Aims: We investigate the effects of thermohaline mixing on C and N abundances using the first comparison between the Gaia-ESO survey [C/N] determinations with simulations of the observed fields using a model of stellar population synthesis.

    Methods: We explore the effects of thermohaline mixing on the chemical properties of giants through stellar evolutionary models computed with the stellar evolution code STAREVOL. We include these stellar evolution models in the Besancon Galaxy model to simulate the [C/N] distributions determined from the UVES spectra of the Gaia-ESO survey and to compare them with the observations.

    Results: Theoretical predictions including the effect of thermohaline mixing are in good agreement with the observations. However, the field stars in the Gaia-ESO survey with C and N abundance measurements have a metallicity close to solar, where the efficiency of thermohaline mixing is not very large. The C and N abundances derived by the Gaia-ESO survey in open and globular clusters clearly show the impact of thermohaline mixing at low metallicity, which explains the [C/N] value observed in lower mass and older giant stars. Using independent observations of carbon isotopic ratio in clump field stars and open clusters, we also confirm that thermohaline mixing should be taken into account to explain the behaviour of C-12/C-13 as a function of stellar age.

    Conclusions: Overall, the current model including thermohaline mixing is able to reproduce very well the C and N abundances over the whole metallicity range investigated by the Gaia-ESO survey data.

  • Karim, Alavi
    et al.
    Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.
    Schulz, Nils
    Ruhr Univ Bochum, Fac Chem & Biochem, Organ Chem 1, Univ Str 150, D-44801 Bochum, Germany.
    Andersson, Hanna
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Organic Chemistry. Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.
    Nekoueishahraki, Bijan
    Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.
    Carlsson, Anna-Carin C.
    Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden;AstraZeneca R&D, Pepparedsleden 1, Molndal, Sweden.
    Sarabi, Daniel
    Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.
    Valkonen, Arto
    Univ Jyvaskyla, Dept Chem, POB 35, FI-40014 Jyvaskyla, Finland.
    Rissanen, Kari
    Univ Jyvaskyla, Dept Chem, POB 35, FI-40014 Jyvaskyla, Finland.
    Grafenstein, Juergen
    Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.
    Keller, Sandro
    TUK, Mol Biophys, D-67663 Kaiserslautern, Germany.
    Erdélyi, Máté
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Organic Chemistry. Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden;Swedish NMR Ctr, Med Gatan, SE-41390 Gothenburg, Sweden.
    Carbon's Three-Center, Four-Electron Tetrel Bond, Treated Experimentally2018In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 140, no 50, p. 17571-17579Article in journal (Refereed)
    Abstract [en]

    Tetrel bonding is the noncovalent interaction of group IV elements with electron donors. It is a weak, directional interaction that resembles hydrogen and halogen bonding yet remains barely explored. Herein, we present an experimental investigation of the carbon-centered, three-center, four-electron tetrel bond, [N-C-N](+), formed by capturing a carbenium ion with a bidentate Lewis base. NMR-spectroscopic, titration-calorimetric, and reaction-kinetic evidence for the existence and structure of this species is reported. The studied interaction is by far the strongest tetrel bond reported so far and is discussed in comparison with the analogous halogen bond. The necessity of the involvement of a bidentate Lewis base in its formation is demonstrated by providing spectroscopic and crystallographic evidence that a monodentate Lewis base induces a reaction rather than stabilizing the tetrel bond complex. A vastly decreased Lewis basicity of the bidentate ligand or reduced Lewis acidity of the carbenium ion weakens or even prohibits the formation of the tetrel bond complex, whereas synthetic modifications facilitating attractive orbital overlaps promote it. As the geometry of the complex resembles the S(N)2 transition state, it provides a model system for the investigation of fundamental reaction mechanisms and chemical bonding theories.

  • Sturesson, Linda
    et al.
    Öhlander, Magnus
    Stockholm University, Faculty of Humanities, Department of Ethnology, History of Religions and Gender Studies, Ethnology.
    Nilsson, Gunnar
    Stenfors, Terese
    Migrant physicians’ conceptions of working in rural and remote areas in Sweden: A qualitative study2019In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, no 1, article id e0210598Article in journal (Refereed)
    Abstract [en]

    Objective

    To explore migrant physicians’ conceptions about working in rural and remote areas in Sweden to understand what influences their motivation to work in these areas.

    Method and material

    The study employed a qualitative approach with semi-structured interviews with 24 migrant physicians. Transcripts were thematically analysed.

    Results

    Conceptions were identified about foremost work content and tasks, and about living in rural and remote areas. Work content and tasks related to the health care systems, type of health care facility, duties, specialty, resources, patient population, colleagues, and professional development. Conceptions about living concerned geographical characteristics, people living in rural and remote areas, opportunities for travelling, family, leisure activities, social life, and language skills. Conceptions seemed to be influenced by individual, professional and societal aspects from both previous countries and Sweden. Conceptions and biographical aspects both appeared to affect motivation.

    Discussion

    Motivation regarding working in rural and remote areas appeared to be influenced by conceptions of these areas. A specific type of place could be understood as being able to provide (or not) the external conditions needed for fulfilling needs and reaching goals, whether professional or personal, and as a tool for reaching or facilitating the achievement of these. Conceptions of an area can hence affect motivation and choices for where to work and live. However, biographical aspects also impact motivation. Our results indicate that positive rural experience in the recipient country might be a predictor for motivation.

    Conclusion

    Professional and personal life and are intertwined. Conceptions about an area influence willingness to work there. Willingness is also affected by, and intertwined with, other aspects such as previous experiences, age, marital status and family circumstances.

  • Olivo, Gaia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Swenne, Ingemar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Pediatric Endocrinology.
    Zhukovsky, Christina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Tuunainen, Anna-Kaisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Salonen-Ros, Helena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry.
    Larsson, Elna-Marie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Gaudio, Santino
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology. Univ Campus Biomed Roma, Ctr Integrated Res, Area Diagnost Imaging, Rome, Italy.
    Brooks, Samantha J.
    Univ Cape Town, Dept Human Biol, Cape Town, South Africa.
    Schiöth, Helgi B.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
    Reduced resting-state connectivity in areas involved in processing of face-related social cues in female adolescents with atypical anorexia nervosa2018In: Translational Psychiatry, ISSN 2158-3188, E-ISSN 2158-3188, Vol. 8, article id 275Article in journal (Refereed)
    Abstract [en]

    Atypical anorexia nervosa (AN) has a high incidence in adolescents and can result in significant morbidity and mortality. Neuroimaging could improve our knowledge regarding the pathogenesis of eating disorders (EDs), however research on adolescents with EDs is limited. To date no neuroimaging studies have been conducted to investigate brain functional connectivity in atypical AN. We investigated resting-state functional connectivity using 3 T MRI in 22 drug-naive adolescent patients with atypical AN, and 24 healthy controls. Psychological traits related to the ED and depressive symptoms have been assessed using the Eating Disorders Examination Questionnaire (EDE-Q) and the Montgomery-Asberg Depression Rating Scale self-reported (MADRS-S) respectively. Reduced connectivity was found in patients in brain areas involved in face-processing and social cognition, such as the left putamen, the left occipital fusiform gyrus, and specific cerebellar lobules. The connectivity was, on the other hand, increased in patients compared with controls from the right inferior temporal gyrus to the superior parietal lobule and superior lateral occipital cortex. These areas are involved in multimodal stimuli integration, social rejection and anxiety. Patients scored higher on the EDE-Q and MADRS-S questionnaires, and the MADRS-S correlated with connectivity from the right inferior temporal gyrus to the superior parietal lobule in patients. Our findings point toward a role for an altered development of socio-emotional skills in the pathogenesis of atypical AN. Nonetheless, longitudinal studies will be needed to assess whether these connectivity alterations might be a neural marker of the pathology.

  • Gustavsson, Erik
    et al.
    Linköping University, Department of Culture and Communication, Culture and Aesthetics. Linköping University, Faculty of Arts and Sciences.
    Sandman, Lars
    Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
    Etisk analys av pre-expositionsprofylax (PrEP) för hiv2018Report (Other academic)
    Abstract [sv]

    Föreliggande etiska analys rör pre- expositionsprofylax (PrEP) mot hiv som en hivnegativ person kan ta för att minska risken för att drabbas av en hivinfektion. Om PrEP tas som ordinerat ger det en ungefärlig skyddsgrad mot hiv på 85 % jämfört med en kontrollgrupp. Eftersom PrEP inte ger 100 % skydd och inte heller skyddar mot andra sexuellt överförbara sjukdomar så är rekommendationen att det tas i kombination med praktiserandet av säkert sex.

    Den här etiska analysen har gjorts på uppdrag av NT-rådet och behandlar följande två frågeställningar: 1) finns det etiska skäl som talar emot förskrivning av PrEP; (2) hur bör PrEP prioriteras i relation till den etiska plattformen med ett särskilt fokus på huruvida PrEP bör egenfinanseras. Det finns starka skäl att minska smittspridningen av hiv utifrån såväl ett individ- som ett samhällsperspektiv vilket talar för förskrivning av PrEP. I diskussionen kring PrEP har det dock framförts att PrEP skiljer sig från annan preventiv behandling för att minska smittspridning på ett sätt som talar emot att PrEP förskrivs. Den etiska analysen diskuterar ett antal sådana argument: att friska personer utan medicinskt behov behandlas, att det handlar om ett socialt riskbeteende, att individer själva bör ta ansvar för smittspridning genom att ändra sitt beteende, samt risken för resistensproblematik. Slutsatsen är att inte något av dessa motargument är tillräckligt starkt för att tala emot förskrivningen av PrEP.

    När det gäller prioritering av PrEP i relation till den etiska plattformen dras slutsatsen att PrEP hamnar i den lägre delen av prioriteringsskalan baserat på svårighetsgraden hos tillståndet som PrEP riktar sig emot. Det innebär att PrEP skulle kunna vara en kandidat för egenfinansiering.

    Eftersom den etiska plattformen säger mycket lite om vilka åtgärder som bör egenfinaiseras så har analysen utgått från två ramverk presenterade i den internationella literaturen. Trots att flera aspekter av dessa ramverk talar för att PrEP skulle vara passande för egenfinansiering så väger aspekten av minskad smittspridning tungt. Dessa positiva externa effekter tillsammans med svårigheten att bedöma huruvida patientpopulationen skulle kunna egenfinansiera PrEP bidrar till bedömningen att PrEP bör finansieras inom ramen för det offentliga åtagandet.

  • Thompson, Haydn
    et al.
    THHINK Wireless Technologies.
    Reimann, Meike
    Steinbeis 2i.
    Ramos-Hernandez, Daniela
    THHINK Wireless Technologies.
    Bageritz, Steve
    Steinbeis 2i.
    Brunet, Adrien
    Steinbeis 2i.
    Robinson, Charles
    Thales.
    Sautter, Björn
    FESTO.
    Linzbach, Johannes
    FESTO.
    Pfeifer, Holger
    fortiss.
    Aravantinos, Vincent
    fortiss.
    Törngren, Martin
    KTH, School of Industrial Engineering and Management (ITM), Machine Design (Dept.), Mechatronics.
    Asplund, Fredrik
    KTH, School of Industrial Engineering and Management (ITM), Machine Design (Dept.), Mechatronics.
    de Sutter, Isabelle
    Systematic Paris Region.
    Platforms4CPS, Key Outcomes and Recommendations2018Report (Other academic)
    Abstract [en]

    Europe has key strengths in the CPS domain with many world leading companies in important business sectors such as Automotive, Aerospace, Rail, Energy and Health, as well as supporting technology and research providers in terms of SMEs and academia. This document summarises the findings of the Platforms4CPS project, co-financed by the European Commission under the H2020 Research and Innovation Programme, to identify business opportunities, develop a CPS Community Roadmap, a Technology and Research Radar and make recommendations for strategic action required for operational and future deployment of Cyber-Physical Systems (CPS). In order to exploit the business opportunities highlighted in this report, recommendations are provided for Research, Innovation, Societal, Legal and Business challenges, that need addressing to ensure that:

    The right technology areas are supported

    There is successful transfer of new ideas to European companies via innovation mechanisms

    Societal concerns which are barriers to uptake of new technologies such as trust, privacy, regulation, liability, and security of employment are addressed

    European citizens can rely on trustable systems

    In the shorter term these can begin to be addressed under Horizon 2020 and existing Digitising European Industry activities via engagement with and expansion of the Digital Innovation Hubs, linking PPPs to work in synergy and supporting the development of platforms and large-scale pilots in key domains such as Automotive, Agriculture, Medicine, etc. Further in the future the recommendations address Horizon Europe linking with developing ideas within the Commission such as the Edge 2030 vision.

  • Björk, Anne
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrinology and mineral metabolism.
    Mellström, Dan
    Univ Gothenburg, Inst Med, Dept Internal Med & Clin Nutr, Geriatr Med, Gothenburg, Sweden.
    Ohlsson, Claes
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Ctr Bone & Arthrit Res, Gothenburg, Sweden.
    Karlsson, Magnus
    Lund Univ, Skane Univ Hosp, Dept Clin Sci & Orthoped Surg, Malmo, Sweden.
    Mallmin, Hans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Johansson, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Ljunggren, Östen
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrinology and mineral metabolism.
    Kindmark, Andreas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrinology and mineral metabolism.
    Haplotypes in the CYP2R1 gene are associated with levels of 25(OH)D and bone mineral density, but not with other markers of bone metabolism (MrOS Sweden)2018In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 12, article id e0209268Article in journal (Refereed)
    Abstract [en]

    Objective: Polymorphisms in the CYP2R1 gene encoding Vitamin D 25-hydroxylase have been reported to correlate with circulating levels of 25-OH vitamin D3 (25(OH)D). It is unknown whether these variations also affect overall bone metabolism. In order to elucidate the overall associations of polymorphisms in the CYP2R1, we studied haplotype tagging single nucleotide polymorphisms (SNPs) in the gene and serum levels of 25(OH)D, calcium, phosphate, parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF23), as well as bone mineral density (BMD).

    Methods: Baseline data on serum parameters and BMD from MrOS Sweden, a prospective population-based cohort study of elderly men (mean age 75 years, range 69-81), were analyzed. Genotyping was performed for eight SNPs covering the CYP2R1 gene in 2868 men with available samples of DNA. Subjects were followed up concerning incidence of fracture during five years.

    Results: There was a significant genetic association with circulating levels of 25(OH)D (4.6-18.5% difference in mean values between SNP alleles), but there were no correlations with levels of calcium, phosphate, PTH or FGF23 for any genetic variant. No differences were found in fracture incidence between the variants. There was an inverse relationship between lower BMD and concomitant higher 25(OH)D for three of the haplotypes (p < 0.005).

    Conclusions: Common variants in the CYP2R1 gene encoding Vitamin D 25-hydroxylase correlate with levels of circulating 25(OH)D but do not otherwise associate with measures of calcium and phosphate homeostasis. Presence of the specific haplotypes may be an indicator of risk for low 25(OH)D levels, and may in addition be correlated to bone mineral density.

  • Lalander, Rickard
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Environmental Science.
    Indigeneidad y diálogos interculturales en la política local: Una etnografía del Estado sobre los Kichwas de Cotacachi y Otavalo2018In: Imbabura Étnica / [ed] Albert Arnavat, Ibarra, Ecuador: Editorial UTN/ Universidad Técnica del Norte , 2018, p. 73-113Chapter in book (Other academic)
    Abstract [es]

    El objetivo principal del presente texto es examinar y problematizar la politización de la indigeneidad mediante el enfoque analítico en los encuentros y diálogos interculturales, y más específicamente de los Kichwas de Cotacachi y Otavalo, localidades tradicionalmente marcadas por las estructuras sociales excluyentes y racistas. Dentro del marco de la democracia deliberativa intercultural y las estructuras de oportunidades políticas, se analizarán las alianzas sociopolíticas de diferentes agrupaciones de ciudadanos y colectivos indígenas, que anteriormente estuvieron excluidas de las esferas públicas, y que confrontan nuevos desafíos y dilemas una vez que emergen como autoridades políticas a nivel local. ¿Cómo se reflejan las complejidades identitarias y de las alianzas interculturales en los procesos político-electorales locales de Cotacachi y Otavalo desde las perspectivas de los actores indígenas? Teóricamente y metodológicamente, la presente etnografía del Estado enfoca concretamente en el las transformaciones de los vínculos entre las poblaciones indígenas de Cotacachi y Otavalo y el Estado, asimismo considerando los diálogos y alianzas interculturales del movimiento indígena en las dos localidades. Estos procesos asimismo conllevan modificaciones de la indigeneidad, considerando que el grupo étnicamente definido siempre se autoidentifica en relación con otra categoría étnica, es decir: ¿Qué pasa con la identidad étnicamente definida cuando el movimiento colectivo llega a la posición de autoridad del Estado? Esta aproximación se sostiene metodológicamente en trabajo etnográfico en el campo, con una gran cantidad de entrevistas, conversaciones informales y observaciones participativas durante períodos en Cotacachi y Otavalo entre 2004 y 2018, así como una lectura crítica de publicaciones de los temas. Asimismo, hasta cierto grado se utiliza una aproximación metodológica comparativa, pero hay que aclarar que no se ofrecerá una comparación completamente sistemática entre los dos casos, más bien se destacarán las características y complejidades particulares de los dos contextos.

  • Uppenberg, Thomas
    et al.
    Umeå University, Faculty of Social Sciences, Department of Economics.
    Westin, Lars
    Umeå University, Faculty of Social Sciences, Department of Economics.
    Turismens ekonomiska effekter i Västernorrlands län 1977-19791981Report (Other academic)
  • Granmar, Claes
    Stockholm University, Faculty of Law, Department of Law.
    E-commerce and the EU data protection regulation2018Conference paper (Other academic)
  • Granmar, Claes
    Stockholm University, Faculty of Law, Department of Law.
    E-commerce and the EU data protection regulation2018Conference paper (Other academic)
  • Granmar, Claes
    Stockholm University, Faculty of Law, Department of Law.
    C-284/16 Achmea Precludes Investor-State Dispute Settlements2018Other (Other academic)
  • Butler, Nick
    Stockholm University, Faculty of Social Sciences, Stockholm Business School.
    Publish and perish: Clark, T., M. Wright and D.J. Ketchen, Jr. (eds.) (2016) How to get published in the best management journals. Edward Elgar: Cheltenham and Northampton, Mass.2018In: Ephemera : Theory and Politics in Organization, ISSN 2052-1499, E-ISSN 1473-2866, Vol. 18, no 2, p. 411-416Article, book review (Other academic)
  • Becker, Juliane
    et al.
    DEUTSCHES KREBSFORSCHUNGSZENTRUM, RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG.
    Jäschke, Andres
    DEUTSCHES KREBSFORSCHUNGSZENTRUM, RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG.
    Samanta, Ayan
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry. DEUTSCHES KREBSFORSCHUNGSZENTRUM, RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG.
    Wiessler, Manfred
    DEUTSCHES KREBSFORSCHUNGSZENTRUM, RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG.
    MULTIPLE ORTHOGONAL LABELLING OF OLGONUCLEOTIDES2016Patent (Other (popular science, discussion, etc.))
    Abstract [en]

    In Summary, the present invention concerns a method for multiple orthogonal labelling of oligonucleotides, preferably RNA or DNA, by simultaneously performing the inverse Diels-Alder reaction (DAinv) and the copper-catalyzed click reaction (CuAAC), wherein the method is employed in a single step by just adding the different reaction components together and incubating the aqueous reaction mixture prefer ably for one hour at room temperature. In detail, the reaction components are one or more N-modified labels, a copper compound, a stabilizing ligand, a reducing agent and one or more electron-deficient label-modified dienes that are added together with an at least double-modified oligonucleotide having one more nucleotides containing one or more N3-re active groups and one or more electron-rich dienophiles, wherein a terminal alkyne moiety is preferably used as N3-re active group(s) and afrans-cyclooctene moiety or norbornene is preferably used as electron-rich dienophile(s), more pref erably frans-cyclooctene. Therefore, the present invention provides a one-pot method for post-synthetic multiple orthogonal labeling of oligonucleotides, which allows the site-specific introduction of more than one label, preferably of at least two labels into oligonucleotides after solid-phase synthesis, wherein the DAinv takes place on the dienophile modification only and the CuAAC selectively takes place on the N3-reactive group modification.

  • Public defence: 2019-01-25 13:00 L 70, Borgarfjordsgatan 12
    Holmberg, Jörgen
    University of Gävle, Faculty of Education and Business Studies, Department of Educational sciences, Educational science, Curriculum studies. Institutionen för data- och systemvetenskap, Stockholms universitet, Stockholm.
    Designing for added pedagogical value: A design-based research study of teachers’ educational design with ICT2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In an increasingly digitized world teachers are expected to take on the role of educational designers and use ICT to design in ways that add pedagogical value to teaching and learning. This thesis adopts a design-based research (DBR) approach to: (a) explore and contribute to the educational design processes of teachers of English as a foreign language in their efforts to use ICT for added pedagogical value, (b) examine how ICT is used in educational designs to create/contribute to what the teachers and students describe as added value and (c) explore, problematize and refine DBR as a research approach.

    Literature studies and a collaborative self-study preceded the DBR to guide its focus and implementation. The DBR was carried out over a period of two years in four upper secondary schools in Sweden in which every student had access to their own computer. The research data consists of: (a) audio recorded design conversations, (b) enacted educational designs and design elements as parts of these, (c) reflective log entries written by the participating teachers, (d) focus group interviews with students and (e) the researcher’s field notes.

    Six different theoretical frameworks and models are used in combination in the accompanying articles to analyze the data and achieve the three research aims. The findings show how teachers’ pedagogical reasoning and TPACK development are interconnected and reciprocal aspects of the educational design process and how the externalization of, and reflection on, these aspects is necessary to develop the specific and practical TPACK needed to realize design intentions in situated contexts. A number of challenges and opportunities in the educational process have been identified.

    Moreover, the findings show how ICT was used to contribute added value in educational designs by facilitating: (a) more authentic and seamless learning experiences in external online contexts with both in-class and out-of-class actors irrespective of time and place, (b) an exchange of digital knowledge representations of understanding and practice between different actors, e.g. for the purposes of modelling, supporting cognitive apprenticeship, meta-cognitive self-regulation and formative assessment and (c) new and extended forms of, and opportunities for, collaborative creation and meaning-making.

    The current common focus in DBR on the development of prescriptive design principles is problematized in relation to the findings of the thesis, which illustrate the complex and situated nature of the educational design process. A theoretically and empirically informed design framework (DF) is developed and used as a conceptual tool to guide and analyze educational design processes and enactments. The findings illustrate how the use of the DF and the process of collaborative design reflection contributed to the analysis of the teachers’ design intentions and de facto design practices and to a DBR format that allowed the participants to use their respective competencies in the development of educational designs for added value. The thesis thereby serves as an example of how DBR can be methodically implemented to study and generate increased knowledge about teachers’ design intentions and design practices, develop research-based educational designs in line with teachers’ pedagogical intentions and support their development as educational designers.

  • Zhu, Baiwei
    et al.
    Jönköping University, School of Engineering, JTH, Materials and Manufacturing.
    Seifeddine, Salem
    Jönköping University, School of Engineering, JTH, Materials and Manufacturing.
    Jarfors, Anders E.W.
    Jönköping University, School of Engineering, JTH, Materials and Manufacturing.
    Leisner, Peter
    Jönköping University, School of Engineering, JTH, Materials and Manufacturing.
    Zanella, Caterina
    Jönköping University, School of Engineering, JTH, Materials and Manufacturing.
    A study of anodising behaviour of Al-Si components produced by rheocasting2019In: Solid State Phenomena, ISSN 1012-0394, E-ISSN 1662-9779, Vol. 285, p. 39-44Article in journal (Refereed)
    Abstract [en]

    This paper aims to investigate the anodising behaviour of Al-Si components produced by rheocasting, to understand the effect of the surface liquid segregation (SLS) on the anodising response. The material investigated was EN AC 42000 Al-alloy with an addition of 150 ppm Sr. The component was rheocast and conventionally liquid cast for benchmarking. The RheoMetalTM process was used to prepare slurry and subsequently cast using a vertical pressure die casting machine. Prior to anodising, mechanical grinding was used as pre-treatment method for selected samples as comparison with components in the as-cast state. Anodising was performed on the components using a constant controlled voltage at 25 V, in 1 M H2SO4, at room temperature. The duration of anodising was varied from 30 mins to 120 mins to examine the relationship between oxide layer thickness and the anodising time. The oxide layer was investigated and characterised. The results demonstrated that the presence of the SLS layer, which was enriched with alloying elements, had a significant influence on the anodising behaviour of the cast component. The oxide layer thickness of the components produced by rheocasting and fully liquid casting was measured and compared. The relations between the oxide layer thickness and anodising time, as well as the casting methods are presented and discussed in this paper.

  • Omvärld Teknisk Prognos 20182018Book (Other academic)
  • Law, Lucy
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.
    Beckman Rehnman, Jeannette
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology. Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
    Deminger, Anna
    Klingberg, Eva
    Jacobsson, Lennart T. H.
    Forsblad-d'Elia, Helena
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology. Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
    Factors related to health-related quality of life in ankylosing spondylitis, overall and stratified by sex2018In: Arthritis Research & Therapy, ISSN 1478-6354, E-ISSN 1478-6362, Vol. 20, article id 284Article in journal (Refereed)
    Abstract [en]

    Background: Ankylosing spondylitis (AS) begins early in life and often leads to reduced physical function, but less is known about the impacts it has on health-related quality of life (HRQoL). The aims of this study were to assess HRQoL using the Short Form-36 (SF-36) in a cohort of patients with AS compared with controls and to examine associations between SF-36 scores and spinal radiographic changes, physical function, disease activity and demographic data overall and stratified by sex.

    Methods: A cohort of patients with AS from Western Sweden were assessed using the Modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) with spinal radiographs, clinical examination and questionnaires, including the Bath Ankylosing Spondylitis Metrology Index, Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Disease Activity Score-C-reactive protein (ASDAS-CRP), Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Patient Global (BASG) and SF-36. Each patient's SF-36 results were compared with those of five age-matched and sex-matched persons (n=1055) from the SF-36 Swedish normative population database. Associations between SF-36 physical component summary (PCS) and mental component summary (MCS) scores and disease-related and demographic factors were investigated using univariate and multivariable ogistic regression analyses with PCS and MCS below/above their respective median values as dependent variables.

    Results: A total of 210 patients, age (median, IQR) 49.0 (21.2) years, symptom duration 24.0 (21.0) years, men 57.6% and HLAB27 87.1% were included. Patients with AS scored significantly lower (p<0.001) compared to controls in all SF-36 domains and component summaries; PCS 42.4 (14.5) in AS versus 52.4 (11.8) in controls and MCS 47.9 (20.0) in AS versus 54.1 (10.1) in controls. Both men and women scored significantly lower in PCS compared with MCS. Multivariable logistic regression analyses revealed that living without a partner (OR 2.38, 95% CI 1.00-5.67), long symptom duration (year in decade OR 1.66, 95% CI 1.16-2.37), higher BASFI (OR 1.98, 95% CI 1.46-2.70) and ASDAS 2.1 (OR 3.32, 95% CI 1.45-7.62) were associated with worse PCS, while living without a partner (OR 3.04, 95% CI 1.34-6.91), fatigue (visual analogue scale for global fatigue greater than the median (OR 6.36, 95% CI 3.06-13.19) and ASDAS 2.1 (OR 2.97, 95% CI 1.41-6.25) with worse MCS. Some differences between sexes were observed in the results.

    Conclusions: The patients with AS had significantly lower HRQoL compared with controls. PCS was more affected compared to MCS in both sexes. Both disease-related and demographic factors were associated with HRQoL, partly overlapping for PCS and MCS. Factors associated with HRQoL showed some differences between sexes. By modifying factors, such as ASDAS-CRP and fatigue, HRQoL may potentially be improved.

    Trial registration: ClinicalTrials.gov, NCT00858819. Registered on 9 March 2009. Last updated on 28 May 2015.

  • Segerstedt, Anders
    En inledning till den bästa förklaringen: Liten handbok för uppsats- och examensarbete2019Report (Other academic)