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  • Petersson, Suzanne
    et al.
    Lund Univeristy / Kalmar County Council.
    Clinton, David
    Karolinska Institutet.
    Brudin, Lars
    Kalmar County Council.
    Perseius, Kent-Inge
    The Swedish Red Cross University College.
    Perfectionism in Eating Disorders: Are Long-Term Outcomes Influenced by Extent and Changeability in Initial Perfectionism?2018In: Journal for Person-Oriented Research, ISSN 2002-0244, Vol. 4, no 1, p. 1-14Article in journal (Refereed)
    Abstract [en]

    Purpose: Perfectionism has been found to predict outcomes in the treatment of eating disorders (ED). In the present study, we took advantage of longitudinal data to: a) investigate whether there are different patterns of perfectionism during the first six months after admission in a clinical sample of patients with ED, and b) describe how these patterns are related to long-term outcome. Methods: A sample of patients (N=294) from the Coordinated Evaluation and Research at Specialized Units for Eating Disorders database was divided into clusters according to perfectionism patterns measured with the EDI-2 perfectionism scale at baseline, and six months in treatment. Cluster analysis was performed on the extent and perseverance/changeability of self-oriented and socially described perfectionism. Outcome was measured with the EDI-2 and the SCL-63. Frequencies of eating disorder diagnoses were investigated. Results: Five clusters were identified. Low perfectionism was associated with lower levels of ED and psychiatric symptomatology at baseline. There were no significant differences between clusters on outcome variables at 36-month follow-up. Conclusions: Results indicated better psychiatric and psychological health three years after the initial measure. Patterns of relations between the extent and possible changes of perfectionism, measured with the EDI-P at baseline and after six months, did not appear to be associated with long-term outcomes on psychiatric health ratings.

  • Karlsson, Lena
    et al.
    Mid Sweden University.
    Lindström, Larsåke
    Mid Sweden University, Faculty of Human Sciences.
    Professioner i akademin och akademins professioner2017In: Mitt, ditt och vårt universitet: Att förstå något gemensamt / [ed] Giritly Nygren, K. & Gidlund, K. L., Sundsvall/Östersund: Mid Sweden University , 2017Chapter in book (Other academic)
  • Granklint Enochson, Pernilla
    et al.
    Halmstad University, School of Education, Humanities and Social Science, Centrum för lärande, kultur och samhälle (CLKS), Lärande, Profession och Samhällsutveckling.
    Davidsson, Eva
    Malmö universitet, Malmö, Sweden.
    Hur och på vilket sätt kopplar lärare samman No-undervisningen med elevernas vardag?2018In: FND 2018: Forskning i naturvetenskapernas didaktik: Samhällsfrågor i naturvetenskaplig undervisning, 2018, p. 12-12Conference paper (Refereed)
    Abstract [sv]

    Upplevelser och händelser som sker i elevernas vardag kan ibland problematiseras utifrån en naturvetenskaplig kontext. I denna studie har vi analyserat vi hur lärare,som undervisar elever i årskurs nio, använder sig av elevernas vardagserfarenheter då de undervisar, analysen bygger påKamberelis och Wehunt (2012) definition av hybrid diskurs-praxis. Analysen fokuseraspå den första inledande delen av lektionen, då läraren oftast är den främsta aktören i undervisningen. Denövergripande anledningentill att göra dessa analyser är indikationerna i PISA som visar att de svenska eleverna upplever den naturvetenskapliga undervisningen relevant men ointressant. I detta sammanhang blir det därför relevant att undersöka hur lärare talat om naturvetenskap i relation till elevernas vardagserfarenheter. Studien gjordes vid 6 olika skolor där totalt 44 lektioner spelades, dessa lektioners inledningar analyserades. 67 situationer detekterades och kategoriserades i tre övergripande grupper; Vardaglig kontext, Skolkontext och Språklig kontext. Vardagligkontext delades sedan i underkategorier ett exempel är: underkategorin, förklarande berättelser (12 situationer), har vi samlat de situationer där läraren, till synes spontant, hittar på berättelser för att kontextualisera naturvetenskapen. Noterbart är att inga längre berättelser förekom utan samtliga historier var korta kontextualiserande berättelser. Skolkontext hade inga underkategorier utan samtliga situationer referenser till andra skolämnen innebär att läraren relaterar till andra skolämnen genom att beskriva ämnesinnehållet som en del av en större enhet och skapar därmed en hybriditet mellan de olika skolämnena. Vid sex tillfällen gjordes sådana kopplingar till andra ämnen. Språkligkontext har tre underkategorier var av en är, Sammankopplar naturvetenskapliga ord med vardagsord, i denna underkategoriåterfinns främst på en av skolorna och då i ämnet kemi, när eleverna arbetade med ämnesområdet organiska syror. Genom att namnge de organiska syrorna med både vetenskapliga och vardagligt språk ger läraren eleverna möjligheter att se sambandet mellan det kemins ordval, askorbinsyra, och det ordval som görs i vardagen, C-vitamin.

  • Crostini, Barbara
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Linguistics and Philology.
    Le monache bizantine e i loro monasteri: luoghi di santificazione o rifugi di penitenza?2018In: Rivista di Storia della Chiesa in Italia, Vol. 15, no 1, p. 7-24Article in journal (Refereed)
  • Rozman Grinberg, Inna
    et al.
    Lundin, Daniel
    Sahlin, Margareta
    Crona, Mikael
    Berggren, Gustav
    Hofer, Anders
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Sjöberg, Britt-Marie
    A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant2018In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 293, no 41, p. 15889-15900Article in journal (Refereed)
    Abstract [en]

    Class I ribonucleotide reductase (RNR) consists of a catalytic subunit (NrdA) and a radical-generating subunit (NrdB) that together catalyze reduction of ribonucleotides to their corresponding deoxyribonucleotides. NrdB from the firmicute Facklamia ignava is a unique fusion protein with N-terminal add-ons of a glutaredoxin (Grx) domain followed by an ATP-binding domain, the ATP cone. Grx, usually encoded separately from the RNR operon, is a known RNR reductant. We show that the fused Grx domain functions as an efficient reductant of the F. ignava class I RNR via the common dithiol mechanism and, interestingly, also via a monothiol mechanism, although less efficiently. To our knowledge, a Grx that uses both of these two reaction mechanisms has not previously been observed with a native substrate. The ATP cone is in most RNRs an N-terminal domain of the catalytic subunit. It is an allosteric on/off switch promoting ribonucleotide reduction in the presence of ATP and inhibiting RNR activity in the presence of dATP. We found that dATP bound to the ATP cone of F. ignava NrdB promotes formation of tetramers that cannot form active complexes with NrdA. The ATP cone bound two dATP molecules but only one ATP molecule. F. ignava NrdB contains the recently identified radical-generating cofactor MnIII/MnIV. We show that NrdA from F. ignava can form a catalytically competent RNR with the MnIII/MnIV-containing NrdB from the flavobacterium Leeuwenhoekiella blandensis. In conclusion, F. ignava NrdB is fused with a Grx functioning as an RNR reductant and an ATP cone serving as an on/off switch.

  • Public defence: 2018-11-30 13:00 Sal C (Sal Sven-Olof Öhrvik), Kista
    Chang, Peiliang
    KTH, School of Electrical Engineering and Computer Science (EECS), Communication Systems, CoS, Radio Systems Laboratory (RS Lab).
    Cross-Layer Energy-Efficient Mobile Network Design2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    To assure the sustainable development of mobile networks, it is crucial to improve their energy efficiency. This thesis is devoted to the design of energy-efficient mobile networks. A cross-layer design approach is adopted. The resource management at the MAC layer, the network layer as well as the service layer are optimized to improve the energy efficiency of mobile networks. The problem of optimizing the MAC-layer resource allocation of the downlink transmission in multi-carrier NOMA systems to maximize the system energy efficiency while satisfying users’ QoS requirements is firstly considered. The optimal power allocation across sub-carriers and across users sharing one sub-carrier are proposed. Furthermore, exploiting the structure of the optimal power allocation across users sharing one sub-carrier, a sub-optimal solution for sub-carrier assignment, which greedily minimizes the required power to serve all users with required QoS, is developed. Besides optimizing the channel assignment and power allocation within a single cell, the link scheduling in the multi-cell scenario to deal with inter-cell interference is also studied. A scalable distributed link scheduling solution is proposed to orchestrate the transmission and DTX micro-sleep of multiple base stations such that both the inter-cell interference and the energy consumption are reduced. At the network layer, the operation of base station sleeping is optimized to improve the energy efficiency of mobile networks without deteriorating users’ QoS. The spectral and energy efficiency of mobile networks, where base stations are enabled with DTX, under different traffic load is firstly studied. It shows that as the networks are more loaded, the link spectral efficiency reduces while the network spectral efficiency increases. Regarding the network energy efficiency, it will either firstly increase and then decrease or always increase when the network load gets higher. The optimal network load to maximize the network energy efficiency depends on the power consumption of base stations in DTX sleep mode. Based on the findings of the above study, the joint optimization of cell DTX and deep sleep to maximize the network energy efficiency is investigated. A scaling law of transmit power, which assures that the distribution of the received power remains unchanged as more base stations are switched into deep sleep, is proposed. Then the average resource utilization and overload probability of non-deep-sleep base stations are derived. Based on these results, the feasible range of the percentage of deep-sleep base stations is obtained. Finally, the optimal percentage of deep-sleep base stations to maximize the network energy efficiency while satisfying users’ QoS requirements is derived. Lastly, the service-layer resource provision of edge computing in mobile networks is optimized to improve the energy efficiency. With this work, the trade-offs on service latency and energy consumption between the computation and the communication subsystems are studied. It is shown that the load of the communication subsystem and that of the computation subsystem should be balanced. Increasing the resource of the highly loaded subsystem can significantly reduce the required resource of the other subsystem. An algorithm is proposed to find out the optimal processing speed and the optimal number of active base stations that minimizes the overall energy consumption while assuring the requirements on the mean service latency.

  • Public defence: 2018-11-30 12:15 111, Sundsvall
    Casales Morici, Belén
    Mid Sweden University, Faculty of Human Sciences, Department of Business, Economics and Law.
    Corporate Entrepreneurship: A Comprehensive Field Review and Assessment of the Internal Organizational Environment Supportive of Strategic Entrepreneurship2018Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    The aim of this thesis is to expand current knowledge on the development of corporate entrepreneurship and to contribute new theoretical and empirical insights into strategic entrepreneurship. To those ends, the thesis attempts to answer two research questions. First, how has the field of corporate entrepreneurship research evolved in terms of main themes, applied methods and theory, and what do these developments reveal about the future trajectories of the field? Second, what is the relationship between internal organizational factors and strategic entrepreneurship in the form of sustained regeneration, organizational rejuvenation, and strategic renewal? To answer the first question, a systematic and comprehensive review of 344 articles addressing the development of research on corporate entrepreneurship during 1969–2017 was conducted. To answer the second question, a survey was administered at a major financial services company to examine the relationship among four internal organizational factors and three forms of strategic entrepreneurship. The overall conclusion of the literature review is that corporate entrepreneurship is a growing and, in several respects, maturing field of research. Signs of its maturity are undermined, however, by the lack of commonly applied theories and theoretical frameworks. Those findings take support from the overall conclusion of the second study, which highlights the need to develop and further test empirically existing frameworks, constructs, and theoretical connections within literature on strategic entrepreneurship.

    Taken together, the findings of the thesis suggest that corporate entrepreneurship faces the difficult challenge of developing a set of more distinct, unifying theories and conceptual frameworks. Concerning strategic entrepreneurship, it is concluded that research on this topic should consider specific organizational structures and conditions of the company and, at the same time, it should also develop greater sensitivity to the effects of industry and institutional settings. The findings also highlight that internal organizational factors could have differentiated effects on the main forms of strategic entrepreneurship.

  • Harris, Ashleigh
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of English.
    "The island is not a story in itself": apartheid's world literature2018In: Safundi: The Journal of South African and American Comparative Studies, ISSN 1753-3171, E-ISSN 1543-1304, Vol. 19, no 3, p. 321-337Article in journal (Refereed)
    Abstract [en]

    This paper makes two related claims: first I argue that the trope of the island works as a hieroglyph of the apartheid state's disavowal of Robben Island and all that it represented; and secondly, I illustrate how the texts under analysis also configure the apartheid state as the disavowed of the international community. To do this, I discuss Athol Fugard, John Kani, and Winston Ntshona's The Island (1973) and J.M. Coetzee's Foe (1986), both of which thematize South African economic and moral isolation through the trope of the island. Both these texts dramatize the moral conditions of life under apartheid within a distinctly transnational frame. As such, I argue, they de-territorialize apartheid and read it as folded-in to its global moment.

  • Haikola, Simon
    et al.
    Linköping University, Department of Thematic Studies, Technology and Social Change. Linköping University, Faculty of Arts and Sciences.
    Hansson, Anders
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences.
    Fridahl, Mathias
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences. Linköping University, Centre for Climate Science and Policy Research, CSPR.
    Views of BECCS among modelers and policymakers2018In: Bioenergy with carbon capture and storage: From global potentials to domestic realities / [ed] Mathias Fridahl, Brussels: Liberal European Forum , 2018, p. 17-31Chapter in book (Refereed)
    Abstract [en]

    Chapter 3 (“Views of BECCS Among Modelers and Policymakers”) moves from exploring the magnitude of BECCS deployment in climate scenarios to outlining caveats raised by modelers themselves. The chapter addresses how modelers navigate the landscape of political and academic pressures to deliver timely, insightful, and relevant policy advice despite inherent and crucial uncerttainties and increasing model complexity. Based on interviews with modelers, the chapter discusses perspectives on uncertainty, the communication of IAM results, and the models’ relationship to reality. The chapter also discuss views of BECCS among policymakers whom generally want to give relatively low priority to investments in BECCS. Failing to invest in the future delivery of BECCS, combined with today’s lack of mitigation ambition, limits future generations’ maneuvering room to resolve the climate crisis.

  • Public defence: 2018-12-05 10:00 Magnélisalen, Kemiska övningslaboratoriet, Stockholm
    Shatskiy, Andrey
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Ru-Based Water Oxidation Catalysts: Development and Mechanistic Studies2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Oxidation of water constitutes one of the most challenging processes in artificial photosynthesis, which aims at storing solar energy in the form of chemical bonds of high-energy fuels. To facilitate this process, efficient and durable water oxidation catalysts have to be developed and integrated into the complete photosynthetic cells. Importantly, the intricate complexity of such devices requires the catalyst not only to be highly efficient and robust, but also operate through a well-defined mechanism.

    This thesis describes the development and mechanistic studies of new water oxidation catalysts based on ruthenium. The first part of the thesis describes the synthesis of a dinuclear ruthenium-based catalyst active for both chemical and light-driven water oxidation. This catalyst displayed a pronounced influence of the acetonitrile co-solvent on the redox properties, which was studied in detail by electrochemical methods. In the second part, a new benzimidazole-based mononuclear catalyst was evaluated. The activity of the catalyst was studied for chemical and light-driven water oxidation, and insight into the operating mechanism was provided with the help of density functional theory calculations. In the third part of the thesis, a new mononuclear ruthenium-based catalyst was prepared and evaluated for electrochemically-driven water oxidation. This catalyst displayed activity similar to that of the current state-of-the-art water oxidation catalyst, while eliminating its main drawback, that is incomplete activation. The redox properties of the new catalyst were studied in detail by electrochemical and spectroscopic techniques, providing insight into the origins of its improved performance. Finally, in the fourth part of the thesis, a heterogeneous nanoparticulate catalyst immobilized on a solid support is described. The catalyst displayed high activity and stability during chemical and light-driven water oxidation, which was attributed to the small average particle size and efficient anchoring of the catalyst to the heterogeneous support via an oxidatively-stable linker.

  • Public defence: 2018-12-05 13:00 Nordenskiöldsalen, Geovetenskapens hus, Stockholm
    Zurita, Javier
    Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
    Amino acids with relevance to health, climate and the environment: Development of mass spectrometric methods2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Amino acids play vital roles in health, either in their native form or chemically modified. Some studies have linked certain non-proteinogenic amino acids to neurodegenerative diseases, such as in the case of β-methylaminoalanine (BMAA). Various environmental pollutants, including carcinogenic polycyclic aromatic compounds, are able to react forming adducts with blood proteins. Amino acids may also be essential in chemical ecology as constituents of flower nectar, potentially used by common feeders as butterflies to synthesize pheromones. Additionally, proteinaceous materials have been detected in aerosols with an apparent potential to influence climate, possibly having a role in cloud formation.

    The determination of amino acids presents many challenges, due to the fact that they are most often constituents of complex sample matrices that contain a high level of chemical interferences. In this respect, mass spectrometry (MS) is a selective and sensitive analytical tool that can be used to measure amino acids in biological samples.

    In this work, several analytical methods based on MS were developed. (i) First, derivatization with a permanently charged N-hydroxysuccinimide ester of N-butylnicotinic acid (C4-NA-NHS) was used to increase the sensitivity and selectivity for amino acids. This strategy was applied to localize BMAA in both visceral and non-visceral parts of blue mussels. (ii) Moreover, a method was developed to separate and determine L- and D- BMAA in cycad seeds by derivatization with a chiral reagent, (+)-1-(9-fluorenyl) ethyl chloroformate (FLEC). Together with L-BMAA, appreciable amounts of D-BMAA (50.13 ± 0.05 and 4.08 ± 0.04 µg BMAA/g Cycas micronesica, wet weight, respectively) were detected for the first time after enzymatic digestion, suggesting D-BMAA may be bound to proteins or may be a conjugate and released only after hydrolysis. (iii) Derivatization with C4-NA-NHS was applied as well for the determination of amino acids in nectar of Bunias orientalis. The presence of tryptophan and phenylalanine, purportedly used to synthesize anti-aphrodisiac pheromones by nectar feeders (adult male butterflies), could then be observed. (iv) Furthermore, the profiling of amino acids in Arctic aerosols was carried out and was used to measure the contribution of free and polyamino acids in aerosol formation. Levels detected were in the range of 0.02-2914 pmol/m3 sampled air. For the first time the measurement of polyamino acids in the Arctic atmosphere was reported. Additionally, possible anthropogenic and marine sources were suggested. The results support the hypothesis that proteinaceous materials act as cloud condensation nuclei over the Arctic. (v) Finally, a method was developed employing selective chromatography/high-resolution MS to identify histidine and lysine adducts in serum albumin of mice exposed to the carcinogen benzo(a)pyrene, as well as in human samples in vivo. Adduct isomers from diol epoxide metabolites could be detected in serum albumin from human samples at attomole/mg levels. This work shows the possibility of future exposure measurements from these compounds in different groups of the population.

    This thesis presents the development of improved analytical methodologies for detecting and identifying trace levels of amino acids, to investigate their relevance in health, climate and the environment.

  • Public defence: 2018-11-29 08:30 Sal T1, Flemingsberg
    Lindblad, Marléne
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH).
    Exploring patient safety in home healthcare: a resilience engineering approach2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The overall aim of the thesis is to increase knowledge and understanding of patient safety in home healthcare. This thesis has an explorative mixed-methods design, with both qualitative (Papers І and ІІ) and quantitative (Papers ІІІ, ІV and V) methods. Data for Papers І and ІІ were collected at three specialised home healthcare units. The aim for Paper І was to explore patient safety in home healthcare from the multidisciplinary teams and clinical managers’ perspective. Data collection for the study was done through sevenindividual and nine focus group interviews, a total of 51 participants, and analysed with qualitative content analysis. The aim of Paper ІІ was to explore the medication management process. The data collection was done by observing the medication management process for 27 days, 9 days per unit, and through interviews with the healthcare professionals who had been observed.Data was collected in iterative phasesand analysed with grounded theory.The aim of Paper ІІІ was to develop a trigger tool for structured retrospective record review to identify adverse events and no-harm incidents and their preventability that affect adult patients admitted into home healthcare. Another aim was to describe how the development was conducted. During the development, the trigger tool was tested twice, using 60 and 600 records, respectively, from ten different organisations from nine different regions across Sweden. The same 600 randomised home healthcare records were usedfor Papers ІV and V. The aim of Paper ІV was to explore the incidence, types and preventability of adverse events using the trigger tool. For Paper V the aim was to explore cumulative incidence, preventability, types and potential contributing causes of no-harm incidents using the trigger tool. Studies ІІІ, ІV and V were analysed with descriptive statistics.The results showed that the clinical managers and the multidisciplinary teams considered patient safety as associated with their common mind-set of safe care, based on a well-established care ideology. This mindset included the establishment of a trustworthy relationship with patients and relatives. At the same time, provision of care in a home was characterised by weighing valuesagainst each other, between risks and patients’ and relatives’ autonomy and wishes. Other typical contradictory valueswere between collecting measurements for different quality registers (directives from policy-makers as a measure of vquality and safety), or taking time for patient needs. Strategies and behaviours, such as not following routines, to get around problematic processes were the result of conflicting goals that either promoted or prevented patient safety (Papers І and ІІ). Results from Study ІІІ showed that the empirically tested triggers identified more triggers compared to several other studies and thus formed a rich material for validation. More than a third of the patients in home healthcare were affected by adverse events (37.7%), most of which were deemed preventable (71.6%). Most adverse events (69.1%) were temporary and led to that the patient required extra healthcare visits or led to a prolonged period of healthcare. The most common adverse events were “healthcare-associated infections, falls and pressure ulcers (Study ІV). Almost every third patient (29.5%) was affected by a no-harm incident, one-fifth of which were deemed preventable (21.2%). The most common types of no-harm incidents were “fall without harm,” “deficiencies in medication management,” and “moderate pain”. “Deficiencies in medication management” were deemed to have a preventability rate (98.4%)twice as high as “fall without harm” (40.9%)and “moderate pain” (50.0%). The most common potential contributing cause of “fall without harm” was “deficienciesin nursing care, i.e., delayed, erroneous, omitted or incomplete care”. For “deficiencies in medication management” and “moderate pain” the most common contributing cause was “delayed, erroneous, omitted or incomplete treatment”. Of the total number of no-harm incidents, the most common contributing causes were “deficiencies in nursing care, treatment or diagnosis” and “deficiencies in communication, information or collaboration” (PaperV).The conclusion is that patient safety is generally strengthened by the fact that clinical managers and multidisciplinary teams have a common approach to safety built on an internationally and national well-established care ideology, whichforms a “dyad” with safe care. In home healthcare, patient safety is formed by the team creating a trustworthy relationship with patients and their families and involving them as partners in their own care. Additionally, the trigger tool and associated manual adapted for home healthcare may be a valid method for identifying cumulative incidence, types, preventability and contributing causes for adverse events and no-harm incidents. Such patient safety knowledge canbe used to develop valid process indicators for systemic failures, as well as outcome indicators for structured evaluation and lead to proactive patient safety work in home healthcare

  • Lakemond, Nicolette
    et al.
    Linköping University, Department of Management and Engineering, Project Innovations and Entrepreneurship. Linköping University, Faculty of Science & Engineering.
    Holmberg, Gunnar
    Linköping University, Department of Management and Engineering, Project Innovations and Entrepreneurship. Linköping University, Faculty of Science & Engineering.
    A Manifesto for Management in Future Industrial Ecosystems for Complex Intelligent Systems2018Report (Other academic)
    Abstract [en]

    THE CHALLENGE: Extensive research efforts are ongoing to ensure long-term competitiveness for Swedish system building industry, such as WASP[1] (Wallenberg AI, Autonomous Systems and Software Program), where technology development, including software development, for future intelligent systems is addressed. This development has potentially major consequences for organizations that develop, provide, and utilize future complex and intelligent systems. Maintaining some of these systems’ functions will be crucial to many functions in society, such as various infrastructure like transport systems, communications systems, and healthcare. The development is disruptive in character and changes the conditions for the actors in the system-building industry (see WASP’s Technology Foresight 2018). Closely related to this technology development, a number of management challenges are emerging, such as:

    The emergence of ecosystems for dynamic and intelligent platform-based systems. This overthrows traditional principles of organizational design that are often based on direct mirroring of the system architecture (also referred to as "mirroring hypothesis" / Conway's law), where a typical situation is that there is a responsible organizational unit for each subsystem in the system. In the face current developments, new perspectives on the links between the system architecture and the organization need to be developed as a result of the emergence of ecosystems, new types of layered system architectures, the intelligent evolution of systems, the creation of training data, and the emergence of new types of actors such as data factories.

    Complexity beyond human cognitive understanding creates a need to re-evaluate existing insights into bounded rationality (Simon, 1972) into a new understanding of rationality that recognizes that human cognition and the intelligence of systems are strongly interwoven. Such rationality may be understood as generative and open and potentially culminates in a paradigm shift in management knowledge. Based on this, new management approaches need to be developed, e.g. how emerging complexity can be embraced (Garud et al., 2013).

  • Karlsson, Jan
    et al.
    Halmstad University, School of Health and Welfare, Centre of Research on Welfare, Health and Sport (CVHI).
    Winroth, Jan
    Högskolan Väst, Trollhättan, Sweden.
    Bremander, Ann
    Halmstad University, School of Business, Engineering and Science, The Rydberg Laboratory for Applied Sciences (RLAS).
    Haglund, Emma
    Halmstad University, School of Business, Engineering and Science, The Rydberg Laboratory for Applied Sciences (RLAS).
    Holmquist, Mats
    Halmstad University, School of Health and Welfare, Centre of Research on Welfare, Health and Sport (CVHI).
    Lindgren, Eva-Carin
    Halmstad University, School of Health and Welfare, Centre of Research on Welfare, Health and Sport (CVHI).
    Lydell, Marie
    Halmstad University, School of Health and Welfare, Centre of Research on Welfare, Health and Sport (CVHI).
    Staland Nyman, Carin
    Halmstad University, School of Health and Welfare, Centre of Research on Welfare, Health and Sport (CVHI).
    Förändringsledarskap vid digital transformation inom vård och omsorg: En sammanfattande rapport från kompetensutvecklingsprojektet ”Trygg motivation och inspiration” i Kungsbacka kommun 20182018Report (Other academic)
  • Schulte, Jesko
    et al.
    Blekinge Institute of Technology, Faculty of Engineering, Department of Strategic Sustainable Development.
    Hallstedt, Sophie
    Blekinge Institute of Technology, Faculty of Engineering, Department of Strategic Sustainable Development.
    Company Risk Management in Light of the Sustainability Transition2018In: Sustainability, ISSN 2071-1050, E-ISSN 2071-1050, Vol. 10, article id 4137Article in journal (Refereed)
    Abstract [en]

    Many of the most important business and economic risks are directly linked to environmental and social issues. This includes both threats and opportunities, not only in relation to reputation, which is often mentioned in this context, but, even more importantly, in relation to innovation capability and legislative change on inevitably more and more sustainability-driven markets. It is, however, unclear through which mechanisms such sustainability risks currently affect companies and how they can be systematically identified and managed. Based on the Framework for Strategic Sustainable Development, this study investigates the dynamics and implications of society’s sustainability transition from a company risk management perspective. In addition, exploratory and descriptive studies were conducted at two large product innovation companies to identify current risk management practices and preconditions for sustainability integration. The results reveal that a society moving closer towards a collapse of environmental and social systems leads to increasing sustainability-related threats for unsustainable businesses and increasing opportunities for sustainable businesses. Also, risk management is found to be a promising way for maneuvering in a smart zone between being too passive and being too pro-active in relation to sustainable innovation.The study participants at the case companies were knowledgeable about risk management in general but were largely unfamiliar with risks associated with sustainability and no processes or support tools exist to work systematically with such risks. Key steps to accomplishing an integration of a strategic sustainability perspective into risk management are proposed as: (i) identifying the effects of sustainability issues on internal and external stakeholder value; (ii) actively including sustainability in objective setting and cascading objectives across the levels of the organizational hierarchy; and (iii) developing concrete support for identifying, assessing, and managing economic sustainability risks. Thereby, companies can enhance their competitiveness while providing leadership in the sustainability transition.

  • Quennerstedt, Mikael
    Örebro University, School of Health Sciences.
    Social media as a health resource: A salutogenic perspective2018In: Young People, Social Media and Health / [ed] Victoria Goodyear & Kathleen Armour, London, UK: Routledge, 2018, p. 71-85Chapter in book (Refereed)
    Abstract [en]

    This chapter explores the consequences of pathogenic notions of health in terms of a focus on risk and disease. A salutogenic perspective is an alternative way of discussing young people, social media, and health. In a salutogenic perspective, health resources are the main focus. A salutogenic perspective can help to identify new and diverse resources that young people draw upon to support their health development, such as social relations and/or critical awareness. As a consequence, this chapter highlights the pedagogical potential of social media and how it can educate about health as part of living a good life.

  • Biedenbach, Galina
    et al.
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Business Administration.
    Boström, Gert-Olof
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Business Administration.
    A data-driven lab in the context of open data: opportunities and challenges for a sustainable business model2018Report (Other academic)
    Abstract [en]

    The report investigates theoretical and practical perspectives on sustainable business models in the context of open data. The main purposes of this report are (1) to investigate the opportunities and challenges for establishing a regional data-driven lab in the context of open data, and (2) to explore the possibility of developing a sustainable business model for a data-driven lab in Umeå (Västerbotten). The report examines conceptualizations of open data that initially emerged in the public sector and highlights the requirements open data are expected to comply with. The report identifies several types and categories of open data, which can be used to provide a variety of benefits for the public and private sectors, stimulate data-driven innovation, and enhance public value. In addition, the report acknowledges the barriers to the publishing and re-use of open data. The review of contextual conditions includes prominent examples of international, regional, and national initiatives for stimulating practical activities and policy-making in the context of open data. Furthermore, the report addresses different theoretical perspectives on how to conceptualize business models, ranging from presenting a company’s organization and its strategic view to emphasizing the elements required for creating, delivering, and capturing value in a specific context. The report elaborates upon the capacities of sustainable business models to achieve long-term success through business model innovation and to address environmental and social challenges while sustaining economic performance. Furthermore, the report emphasizes the importance of considering a complex ecosystem engaging diverse stakeholder groups and the open data lifecycle for developing a successful business model in the context of open data. The report reviews the business models used in the open data industry and discusses the important practical considerations for a data-driven lab. Overall, the report emphasizes the critical importance of creating the conditions that will enable the valuable resource of open data to be exploited and prioritizing the establishment of a regional data-driven lab by considering its potential to stimulate data-driven innovation and increase public value for society.

  • Tseronis, Assimakis
    et al.
    University of Amsterdam, Amsterdam, Netherlands.
    Forceville, Charles
    University of Amsterdam, Amsterdam, Netherlands.
    Grannetia, Melle
    University of Amsterdam, Amsterdam, Netherlands.
    The argumentative role of visual metaphor and visual antithesis in ‘fly-on-the-wall’ documentary2015In: Proceedings of the International Society for the Study of Argumentation / [ed] Bart Garssen; David Godden; Gordon Mitchell; Francisca Snoeck Henkemans, 2015, p. 1380-1395Conference paper (Other academic)
    Abstract [en]

    In this paper, we explore the argumentative role of visual metaphor and visual antithesis in theso- fly-on-the-wall documentary. In this subtype of documentary, which emphatically renouncesvoice-over narration, the filmmakers guide their viewers into reaching certain conclusions by makingchoices regarding the editing as well as the cinematography. We analyse a number of scenes from two filmsby one major representative of the Direct Cinema or fly-on-the-wall documentary, Frederick Wiseman.

  • Tseronis, Assimakis
    Umiversity of Amsterdam, Amsterdam, The Netherlands.
    Argumentative functions of visuals: beyond claiming and justifying2013In: Virtues of argumentation: proceedings of the 10th International Conference of the Ontario Society for the Study of Argumentation (OSSA), 22-26 May 2013 Windsor, ON / [ed] Dima Mohammed; Marcin Lewinski, Ontario Society for the study of Argumentation (OSSA) , 2013, p. 1-17Conference paper (Other academic)
    Abstract [en]

    Up until now, the study of the argumentative role of visuals has been restricted to theformal concept of argument as product, consisting of premises and conclusion. In this paper, I adoptthe pragma-dialectical approach to argumentation as a social and discursive activity in order toexplore argumentative functions of visuals that go beyond claiming and justifying. To do this I payattention to the visual form and to the interaction between the verbal and the visual mode inargumentative discourse.

  • Tseronis, Assimakis
    Laboratoire Communication et Politique, CNRS, Paris, France.
    Les marqueurs d'une stratégie de gestion de la charge de la preuve: franchement et en fait qualifiant une thèse2010In: Revue Verbum, ISSN 0182-5887, Vol. 32, no 1, p. 73-91Article in journal (Refereed)
    Abstract [en]

    Up until now, most studies that deal with the linguistic realization of argumentationare mainly interested in the « indicative potential » of the words and phrases studiedand tend to neglect the potential strategic effect of these words in argumentativediscourse. In this article, I propose a systematic study of “illocutionary adverbs”,such as franchement and honnêtement, when they appear in the utterance thatfunctions as a standpoint. I also argue that the adverbial phrase en fait has the samestrategic effect. In order to account for the strategic role of these adverbs when theyserve as qualifiers of a standpoint, I have recourse to the concept of burden of proof,a concept that is essential to the act of advancing a standpoint. I argue that theseadverbs can be considered as a means at the arguer’s disposal when formulating hisstandpoint to manage the burden of proof to his advantage. As a result, the analystmay consider their presence in the utterance that functions as a standpoint as amarker of the strategy of managing the burden of proof.

  • Tseronis, Assimakis
    University of Amsterdam, Amsterdam, Netherlands.
    Multimodale argumentatie: Bruggen slaan tussen argumentatieleer en multimodale analyse2016In: Tijdschrift voor Taalbeheersing, ISSN 1573-9775, Vol. 38, no 1, p. 1-26Article in journal (Refereed)
    Abstract [en]

    Multimodal argumentation: Building bridges between argumentation theory and multimodal analysis

    Since the end of the 90s there has been an increasing interest in the analysis of images and in their interplay with written language. Even though images, especially when used in advertisements, have already been studied within rhetorical approaches to communication and visual studies, there still lacks a systematic account of their contribution to the way standpoints are put forward and argumentation is advanced. At the same time, within the field of discourse analysis interest has been expressed in the analysis of visual and other non-verbal elements of communication. Nevertheless, no special attention has been paid within this field to those communicative situations where the support of a standpoint with arguments and the acceptability of the argumentation are at stake. In order to be able to analyse the various aspects of multimodal documents on their merits and to account for their argumentative relevance it is necessary to build bridges between argumentation theory and multimodal analysis. This paper discusses critically the current state of affairs regarding the analysis of multimodal documents from an argumentation studies perspective and argues for a systematic study of the interplay of the verbal and the visual modes within the framework of Pragma-dialectics. Three print advertisements are analysed in order to illustrate the merits of such an approach to the argumentative analysis of multimodal documents.

  • Tseronis, Assimakis
    Laboratoire Communication et Politique, Paris, France.
    Use and abuse of the strategic function of in fact and frankly when qualifying a standpoint2011In: Pragmatics: Quarterly Publication of the International Pragmatics Association, ISSN 1018-2101, E-ISSN 2406-4238, Vol. 21, no 3, p. 473-490Article in journal (Refereed)
    Abstract [en]

    This paper seeks to specify the strategic function of adverbs like in fact and frankly when used to qualify the utterance that functions as a standpoint in an argumentative discussion. The aim is to provide a description of their strategic function that takes into consideration the role that the move of advancing a standpoint plays in argumentative discourse. To this direction, the choice of qualifying is explained as a choice that the arguer makes in his attempt to manage the burden of proof that is incurred when advancing a standpoint. By combining the insights from the pragma-linguistic treatment of these adverbs with the theoretical premises of a systematic approach to the analysis of argumentative discourse it becomes possible to specify their strategic function and to evaluate those cases in which this strategic function has been abused to the detriment of the quality of argumentative discourse.

  • Pihl, Christopher
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History.
    Winton, Patrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History.
    Några ytterligare reflektioner kring ett 350-årsjubileum2018In: Ekonomisk Debatt, ISSN 0345-2646, Vol. 46, no 7, p. 58-61Article in journal (Other academic)
  • Ayele, Workneh Y.
    et al.
    Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
    Juell-Skielse, Gustaf
    Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
    Hjalmarsson, Anders
    Johannesson, Paul
    Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
    Unveiling DRD: A Method for Designing Digital Innovation Contest Measurement Models2018In: Systems, Signs & Actions, ISSN 1652-8719, E-ISSN 1652-8719, Vol. 11, no 1, p. 25-53Article in journal (Refereed)
    Abstract [en]

    The growing open data market opens possibilities for the development of viable digital artifacts that facilitate the creation of social and business values. Contests are becoming popular means to facilitate the development of digital artifacts utilizing open data. The increasing popularity of contests gives rise to a need for measuring contest performance. However, the available measurement model for digital innovation contests, the DICM-model, was designed based on a single case study and there is a need for a methodological approach that can accommodate for contests’ variations in scope. Therefore, we use design science to construct a nine-step method, the DRD method, to design and refine DICM-models. The DRD-method is designed using goal- and quality oriented approaches. It extends innovation measurement to the application domain of digital innovation contests and provides an improvement of innovation measurement as it offers a new solution for a known problem. The DRD-method provides comprehensive support to practice for designing and refining DICM-models and supports reflection and organizational learning across several contests. For future study, we suggest an ex-post evaluation of the method inconjunction with real contests and systematic efforts to generalize the method within as well as beyond the context of the contest. Finally, we propose to further investigate the potential of topdown and goal oriented approaches to measure open and iterative forms of innovation.

  • Public defence: 2018-12-14 10:00 Forum Humanum, Jönköping
    Lundgren, Dan
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Leadership, psychosocial work environment, and satisfaction with elder care among care recipients: Analysing their associations and the structural differences between nursing homes and home care2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Background

    Municipal elder care has become increasingly multifaceted, and the quest for quality is a continuing discussion in Swedish elder care. In recent decades, municipalities have prioritized older adults with severe needs. There is also a trend of more elderly individuals receiving care in their own homes. The number of persons 80 years and older will increase by approximately 75 percent between 2015 and 2035. During the same period, the numbers of nursing assistants are likely to decrease. Furthermore, health and social care services have the highest rates of sick leave in Sweden, and the psychosocial work environment plays an important role in reducing sick leave. Perceived support from an organization, leaders and colleagues has been shown to have a positive effect on nursing assistants’ perceptions of the psychosocial work environment in elder care settings. Leadership characteristics or attributes and behaviours have been associated with a healthy work environment. Thus, knowledge regarding the associations between leadership, the psychosocial work environment, and recipient satisfaction in elder care is insufficient.

    Aims

    The overall aim of this thesis was to explore and describe the associations between leadership, the psychosocial work environment, and recipient satisfaction in municipal elder care, the changes over time in psychosocial work environment, and the difference between nursing homes and home care.

    Design and methods

    This thesis is based on four cross-sectional studies (I-IV) and one study based on repeated cross-sectional analyses (V). Data from three different surveys were used: the Developmental Leadership Questionnaire (DLQ), the Questionnaire for Psychological and Social Factors at Work (QPS), and a recipient satisfaction survey (based on a National Board of Health and Welfare recipient satisfaction survey). Study I analyses first-line managers’ assessments of their leadership and nursing assistants’ assessments of their first-line managers. Study II analyses the associations between leadership and the psychosocial work environment, study III the associations between psychosocial work environment and recipient satisfaction, and study IV encompasses all three levels, leadership and the psychosocial work environment, and recipient satisfaction. Study V describes changes in the psychosocial work environment between 2007 and 2015.

    Results

    There are structural differences between nursing homes and home care in the assessments of leadership, the psychosocial work environment, and satisfaction among older people. Linear trends for the period 2007-2015 demonstrate a decline in control at work in both nursing homes and home care and positive trends for stimulus from the work itself. The results also show that nursing assistants in nursing homes rate their psychosocial work environment higher than nursing assistants in home care. Older adults receiving home care report higher satisfaction than those receiving care in nursing homes. In contrast, nursing assistants in home care rate their first-line managers’ leadership and their perceived psychosocial work environment lower than those working in nursing homes. Process-related factors, for example, the association between leadership and the psychosocial work environment, showed that interpersonal factors, such as support from superiors, empowering leadership, human resource primacy, and direct leadership, may impact nursing assistants’ psychosocial work environment in both nursing homes and home care. A better psychosocial work environment among nursing assistants was associated with higher satisfaction among recipients of elder care, except for the recipient satisfaction item staff knowledge, which had negative associations with the psychosocial work environment.

    Conclusions and implications for practice

    To influence nursing assistants’ performance, to increase recipient satisfaction and to increase quality in eldercare in the long term, appropriate leadership and a healthy psychosocial work environment are necessary. To make the most out of the available resources and to meet future challenges (among others) in elder care require organizational attention so that leadership and psychosocial work environments continue to develop in both nursing homes and home care. Therefore, structural differences in elder care must be considered to create a better psychosocial work environment for nursing assistants and, in turn, to create higher care satisfaction for those who are receiving elder care in two different social contexts.

  • Ahlbäck Öberg, Shirin
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Den offentliga verksamhetens villkor2018Other (Other (popular science, discussion, etc.))
    Abstract [sv]

    I Sverige arbetar en tredjedel av arbetskraften i statlig eller kommunal regi. Väljarnas kontaktyta med den offentliga verksamheten är således stor, och ändå skulle jag säga att en sammanhållen diskussion om den offentliga sektorns arbete och organisation – s.k. förvaltningspolitik – har lyst med sin frånvaro i årets valrörelse. För vad vet vi om partiernas hållning till statsförvaltningen och den kommunala förvaltningen?

  • Ching, Rosanna C.
    et al.
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy. Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Hand Surgery.
    Wiberg, Mikael
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy. Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Hand Surgery.
    Kingham, Paul J.
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
    Schwann cell-like differentiated adipose stem cells promote neurite outgrowth via secreted exosomes and RNA transfer2018In: Stem Cell Research & Therapy, E-ISSN 1757-6512, Vol. 9, article id 266Article in journal (Refereed)
    Abstract [en]

    Background: Adipose derived stem cells can be stimulated to produce a growth factor rich secretome which enhances axon regeneration. In this study we investigated the importance of exosomes, extracellular vesicles released by many different cell types, including stem cells and endogenous nervous system Schwann cells (SCs), on neurite outgrowth.

    Methods: Adipose derived stem cells were differentiated towards a Schwann cell-like phenotype (dADSCs) by in vitro stimulation with a mix of factors (basic fibroblast growth factor, platelet derived growth factor-AA, neuregulin-1 and forskolin). Using a precipitation and low-speed centrifugation protocol the extracellular vesicles were isolated from the medium of the stem cells cultures and also from primary SCs. The conditioned media or concentrated vesicles were applied to neurons in vitro and computerised image analysis was used to assess neurite outgrowth. Total RNA was purified from the extracellular vesicles and investigated using qRT-PCR.

    Results: Application of exosomes derived from SCs significantly enhanced in vitro neurite outgrowth and this was replicated by the exosomes from dADSCs. qRT-PCR demonstrated that the exosomes contained mRNAs and miRNAs known to play a role in nerve regeneration and these molecules were up-regulated by the Schwann cell differentiation protocol. Transfer of fluorescently tagged exosomal RNA to neurons was detected and destruction of the RNA by UV-irradiation significantly reduced the dADSCs exosome effects on neurite outgrowth. In contrast, this process had no significant effect on the SCs-derived exosomes.

    Conclusions: In summary, this work suggests that stem cell-derived exosomes might be a useful adjunct to other novel therapeutic interventions in nerve repair.

  • Rodríguez, Maria Angels
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
    Liu, Jing-Xia
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
    Parkkonen, Kimmo
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
    Li, Zhenlin
    Domellöf, Fatima Pedrosa
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
    The Cytoskeleton in the Extraocular Muscles of Desmin Knockout Mice2018In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 59, no 12, p. 4847-4855Article in journal (Refereed)
    Abstract [en]

    Purpose: To investigate the effect of absence of desmin on the extraocular muscles (EOMs) with focus on the structure and composition of the cytoskeleton.

    Methods: The distribution of synemin, syncoilin, plectin, nestin, and dystrophin was evaluated on cross and longitudinal sections of EOMs and limb muscles from 1-year-old desmin knockout mice (desmin−/−) by immunofluorescence. General morphology was evaluated with hematoxylin and eosin while mitochondrial content and distribution were evaluated by succinate dehydrogenase (SDH) and modified Gomori trichrome stainings.

    Results: The muscle fibers of the EOMs in desmin−/− mice were remarkably well preserved in contrast to those in the severely affected soleus and the slightly affected gastrocnemius muscles. There were no signs of muscular pathology in the EOMs and all cytoskeletal proteins studied showed a correct location at sarcolemma and Z-discs. However, an increase of SDH staining and mitochondrial aggregates under the sarcolemma was detected.

    Conclusions: The structure of the EOMs was well preserved in the absence of desmin. We suggest that desmin is not necessary for correct synemin, syncoilin, plectin, and dystrophin location on the cytoskeleton of EOMs. However, it is needed to maintain an appropriate mitochondrial distribution in both EOMs and limb muscles.

  • de Waard, Anne-Karien M.
    et al.
    Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Huispost STR 6-131,POB 85500, NL-3508 GA Utrecht, Netherlands..
    Wändell, Per E.
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Solna, Sweden..
    Holzmann, Martin J.
    Karolinska Univ Hosp, Funct Area Emergency Med, Solna, Sweden.;Karolinska Inst, Dept Internal Med, Stockholm, Sweden..
    Korevaar, Joke C.
    NIVEL Netherlands Inst Hlth Serv Res, Utrecht, Netherlands..
    Hollander, Monika
    Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Huispost STR 6-131,POB 85500, NL-3508 GA Utrecht, Netherlands..
    Gornitzki, Carl
    Karolinska Inst, Univ Lib, Solna, Sweden..
    de Wit, Niek J.
    Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Huispost STR 6-131,POB 85500, NL-3508 GA Utrecht, Netherlands..
    Schellevis, Francois G.
    NIVEL Netherlands Inst Hlth Serv Res, Utrecht, Netherlands.;Vrije Univ Amsterdam Med Ctr, Dept Gen Practice & Elderly Care Med, Amsterdam, Netherlands..
    Lionis, Christos
    Univ Crete, Clin Social & Family Med, Iraklion, Greece..
    Söndergaard, Jens
    Univ Southern Denmark, Res Unit Gen Practice, Odense, Denmark..
    Seifert, Bohumil
    Charles Univ Prague, Dept Gen Practice, Prague, Czech Republic..
    Carlsson, Axel C
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Karolinska Inst, Dept Neurobiol Care Sci & Soc, Solna, Sweden.
    Barriers and facilitators to participation in a health check for cardiometabolic diseases in primary care: A systematic review2018In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 25, no 12, p. 1326-1340Article, review/survey (Refereed)
    Abstract [en]

    Background: Health checks for cardiometabolic diseases could play a role in the identification of persons at high risk for disease. To improve the uptake of these health checks in primary care, we need to know what barriers and facilitators determine participation.

    Methods: We used an iterative search strategy consisting of three steps: (a) identification of key-articles; (b) systematic literature search in PubMed, Medline and Embase based on keywords; (c) screening of titles and abstracts and subsequently full-text screening. We summarised the results into four categories: characteristics, attitudes, practical reasons and healthcare provider-related factors.

    Results: Thirty-nine studies were included. Attitudes such as wanting to know of cardiometabolic disease risk, feeling responsible for, and concerns about one's own health were facilitators for participation. Younger age, smoking, low education and attitudes such as not wanting to be, or being, worried about the outcome, low perceived severity or susceptibility, and negative attitude towards health checks or prevention in general were barriers. Furthermore, practical issues such as information and the ease of access to appointments could influence participation.

    Conclusion: Barriers and facilitators to participation in health checks for cardiometabolic diseases were heterogeneous. Hence, it is not possible to develop a one size fits all' approach to maximise the uptake. For optimal implementation we suggest a multifactorial approach adapted to the national context with special attention to people who might be more difficult to reach. Increasing the uptake of health checks could contribute to identifying the people at risk to be able to start preventive interventions.

  • Berglez, Peter
    et al.
    Jönköping University, School of Education and Communication, HLK, Media and Communication Studies.
    Gearing, Amanda
    Queensland University of Technology, Australia.
    The Panama and Paradise Papers. The Rise of a Global Fourth Estate2018In: International Journal of Communication, ISSN 1932-8036, E-ISSN 1932-8036, Vol. 12, p. 4573-4592Article in journal (Refereed)
    Abstract [en]

    This article theorizes the work of the International Consortium of Investigative Journalists (ICIJ). This work is motivated by the need to link recent large-scale ICIJ projects such as the Panama and Paradise Papers revelations to ongoing theoretical discussions about emergent forms of journalism. It is argued that the ICIJ provides evidence of the emergence of a “global network journalism” characterized by a particular epistemology (a global outlook on social reality) that is embedded in a networked rationale. It is further suggested that this journalistic practice paves the way for the media’s role as a global fourth estate, responding to the budding demand for a new type of reporting that influences political decisions and expressing society’s development toward an internalized sense of globalization. We discuss the usefulness of applying the presented concepts to other cases than the ICIJ and provide suggestions for further studies.

  • Janzon, Lars-Åke
    Ullahaus gaddsteklar, juli 19861987Report (Other academic)
    Abstract [sv]

    Länsstyrelsen i Gotlands län uppdrog åt mig att under 1986 inventera förekomsten av rovstekeln Sphex rufocinctus samt översiktligt övriga gaddsteklar inom naturreservatet Ullahau. För kontroll av eventuell förekomst besöktes även and­ ra lokaler där arten tidigare påtäffats.

  • Sandvig, Axel
    et al.
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience. Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
    Arnell, Kai
    Malm, Jan
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
    Eklund, Anders
    Umeå University, Faculty of Medicine, Department of Radiation Sciences.
    Koskinen, Lars-Owe D.
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
    Analysis of Codman microcerebrospinal fluid shunt2018In: Brain and Behavior, ISSN 2162-3279, E-ISSN 2162-3279, Vol. 8, no 10, article id e01002Article in journal (Refereed)
    Abstract [en]

    Introduction: Ventriculo-peritoneal cerebrospinal fluid (CSF) shunt is the most common method of treating pediatric hydrocephalus. The Codman microadjustable valve (CMAV) is a CSF shunt constructed for children. The objective of the study was (a) to analyze complications after insertion of a CMAV shunt in hydrocephalic children, (b)to analyze complications after replacing a CMAV by an adult-type Codman Hakim adjustable valve shunt (CHAV), and to (c) analyze the in vitro characteristics of the CMAV shunt and correlate the findings with the clinical performance of the shunt.

    Methods: A retrospective study analyzed a cohort of hydrocephalic children who had received a CMAV shunt and later replaced by a CHAV shunt. We report on the complications that resulted from replacing the CMAV with the CHAV. We tested six CMAV shunts with or without an antisiphon device (ASD) in which opening pressure, resistance, sensitivity to abdominal pressure, ASD position dependency, and function were determined. The test results were correlated with the clinical performance of the shunt in the retrospective study.

    Results: Thirty-seven children (19 boys, 18 girls) were identified. Within the first month after shunt placement, a total of 10 patients (27%) developed complications including infections, hygromas, and shunt dysfunction. Shunt survival varied from 1week to 145 months. Over the 10-year follow-up period, 13 children had their shunts replaced, six of them with a CHAV without any further complications. A bench test of the CMAV was done to test whether the opening pressure was in agreement with the manufacturer's specifications. Our results were generally in agreement with specifications stated by the manufacturer.

    Conclusion: Replacing a CMAV with a CHAV was well tolerated by the patients. Bench test results were generally in agreement with manufacturers specifications. Replacing a CMAV with a CHAV in pediatric hydrocephalus patients can be accomplished safely.

  • Jacques, Tristan
    et al.
    Pantheon Sorbonne Univ, Inst Hist Econ & Sociale, Paris, France.
    Sandgren, Fredrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economic History.
    Retail Trade, Consumption, and the Construction of Markets2018In: Scandinavian Economic History Review, ISSN 0358-5522, E-ISSN 1750-2837, Vol. 66, no 2, p. 127-131Article in journal (Other academic)
  • Björndalen, Jörn Erik
    Kalktallskogar på Gotland som naturvårdsobjekt1987Report (Other academic)
    Abstract [sv]

    De gotländska kalktallskogarna är ganska märkvärdiga sedda i ett nordiskt perspektiv. De vanliga, boreala tallskogarna är ofta fattiga och präglade av risväxter, mossor och lavar. Tallskogarna på Gotland växer på kalkrik mark och är mycket rika på örter och gräs. Redan Sernander (1894) urskilj­ de de gotländska tallskogarna som en speciell skogstyp, som han kallade "Pinetum herbidum".

    Gräs- och örtrika tallskogar på kalkrik mark (sk kalktallskogar) kan räknas som en relativt sällsynt vegetationstyp i Norden, en vegetations­ typ som f am till de senaste åren bara i ringa grad blivit dokumenterad i den botaniska litteraturen. Kalktallskogar och besläktade skogstyper . finns likväl spridda över stora delar av Norge, Sverige och Finland,

    även utanför kalkområden (se fig 1). Dessa skogar är emellertid utvecklade som små, glesa och isolerade bestånd. Större, mer välutecklade bestånd med örtrika tallskogar finns tex på Gotland, öland och på några öar i Stockholms skärgård, på Billudden i Uppland, i Västmanland, på Höga kusten, på kambrosilurområdena i Oslofältet, på några kalkrika öar söder om Bergen, på olivinområden i M re och Romsdal, vid Snåsa i Trondelag, i Bod -Fauskeområdet och i Skibotn i norra Norge.

    Arbetet med de gotländska kaltallskogarna ingår i en större vegetations­ ekologisk undersökning av kalktallskogar och besläktade skogstyper i Norden. Detta projekt påbörjades 1978, och en preliminär redovisning har publicerats i Svensk Botanisk Tidskrift (Bj rndalen 1980a)o Detta arbete, som sammanfattar det material som var känt fram till början av 1979, har fungerat som ett diskussionsunderlag för konstruktiv kritik, och många nya lokaluppgifter har influtit från ett stort antal nordiska botanister. Detaljundersökningarna kommer att publiceras i en serie re­ gionala arbeten. Ett område i södra Telemark i Norge har slutredovisats (jfr Bj,rndalen 1980b, 1981). En sammanfattning av de aspekter som rör kalktallskogarnas utbredning och variation längs växtgeografis a gradi­ enter har publicerats i tidskriften Vegetatio (Bj rndalen 1985).

  • Chahlafi, Zahra
    et al.
    Alvarez, Laura
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Cava, Felipe
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Berenguer, José
    The role of conserved proteins DrpA and DrpB in nitrate respiration of Thermus thermophilus2018In: Environmental Microbiology, ISSN 1462-2912, E-ISSN 1462-2920, Vol. 20, no 10, p. 3851-3861Article in journal (Refereed)
    Abstract [en]

    In many Thermus thermophilus strains, nitrate respiration is encoded in mobile genetic regions, along with regulatory circuits that modulate its expression based on anoxia and nitrate presence. The oxygen‐responsive system has been identified as the product of the dnrST (dnr) operon located immediately upstream of the nar operon (narCGHJIKT), which encodes the nitrate reductase (NR) and nitrate/nitrite transporters. In contrast, the nature of the nitrate sensory system is not known. Here, we analyse the putative nitrate‐sensing role of the bicistronic drp operon (drpAB) present downstream of the nar operon in most denitrifying Thermus spp. Expression of drp was found to depend on the master regulator DnrT, whereas the absence of DrpA or DrpB increased the expression of both DnrS and DnrT and, concomitantly, of the NR. Absence of both proteins made expression from the dnr and nar operons independent of nitrate. Polyclonal antisera allowed us to identify DrpA as a periplasmic protein and DrpB as a membrane protein, with capacity to bind to the cytoplasmic membrane. Here, we propose a role for DrpA/DrpB as nitrate sensors during denitrification.

  • Petersson, Jörgen
    Botanisk och ornitologisk inventering av täkt- och påverkansområde för planerat kalkbrott i sydvästra Fleringe1987Report (Other academic)
    Abstract [sv]

    Det finska företaget OY LOHJA AB har ansökt om tillstånd för kalk­ brytning på Utoje 1:7 i Fleringe s:n i Gotlands län. Som underlag för kommande beslut i frågan har författaren, på uppdrag av Länsstyrelsen i Gotlands län, inventerat de berörda områdena. Inventeringen omfattar främst en botanisk undersökning av kärlväxterna samt en översiktlig ornitologisk studie. Vissa noteringar av andra djurgrupper har också gjorts. Inventeringen utfördes från april till augusti år 1987 och be­ stod av 15 besök varierande mellan 4 oc_h 9 timmar.

  • Public defence: 2018-11-30 13:15 Polhemsalen, Uppsala
    Schött, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Theoretical and Computational Studies of Strongly Correlated Electron Systems: Dynamical Mean Field Theory, X-ray Absorption Spectroscopy and Analytical Continuation2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis encompasses theoretical and computational studies of strongly correlated elec-tron systems. Understanding how electrons in solids interact with each other is of great im-portance for future technology and other applications. From a fundamental point of view, the Coulomb interaction in a solid leads to a very challenging many-body problem, encapsulating many physical phenomena, e.g. magnetism. Treating this interaction, with a focus on local contributions, is the subject of this thesis. Both models and materials have been investigated, to obtain insight on the mechanisms determining the macroscopic properties of matter. This thesis is divided in four parts, each corresponding to a different project or topic.

    In the first project a many body method called dynamical mean field theory (DMFT) is used to study the paramagnetic phase of the Hubbard model. A stochastic version of the exact di-agonalization technique is developed for solving the effective impurity model arising in DMFT and generating real frequency spectral functions. In the next project, by combining density functional theory (DFT) with a static solution of the DMFT equations (DFT+U), magnetic ex-change interactions in transition metal oxides (TMOs) are investigated. The spin dependence of the functional is shown to be important for mapping magnetic excitations form the quantum mechanical system to a classical model.

    The next topic in this thesis concerns the x-ray absorption spectroscopy of TMOs. Spectral functions, in good agreement with experimental data, are calculated by combining DFT with multiplet ligand field theory (MLFT). The effects of the presence of a core-hole are studied in detail for NiO, as well as double counting issues related to higher order terms of the multiple ex-pansion of the Coulomb interaction. A strained induced linearly polarized spectrum is obtained for CaTiO3. Lastly, charge disproportionation is seen in Mo doped LaFeO3.

    Finally, a critical step in DMFT, called analytical continuation, to obtain physical observ-ables of interest is investigated. Analytical continuation means a transformation of a function in the complex plane. Several methods for performing this transformation are explained, and in particular steps for improving the robustness and accuracy of the Padé approximant method are described.

  • Pettersson, Lars-Åke
    Östergarnsholm Inventering av häckfågelfaunan 19871988Report (Other academic)
    Abstract [sv]

    Med anledning av att Östergarnsholm är en tänkbar plats för uppförande av vindkraftverk, fick jag våren 1987 i uppdrag av länsstyrelsen i Gotlands län att utföra en in­ ventering av öns häckfågelfauna. Inventeringen utfördes i maj-juli 1987, och resultatet redovisas i det följande.

  • Li, Hu
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Papadakis, Raffaello
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Jafri, Syed Hassan Mujtaba
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Thersleff, Thomas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Michler, Johann
    Empa, Swiss Fed Labs Mat Sci & Technol, Lab Mech Mat & Nanostruct, CH-3602 Thun, Switzerland.
    Ottosson, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC.
    Leifer, Klaus
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Superior adhesion of graphene nanoscrolls2018In: COMMUNICATIONS PHYSICS, ISSN 2399-3650, Vol. 1, article id 44Article in journal (Refereed)
    Abstract [en]

    An emerging material in the carbon family, a graphene nanoscroll (GNS) is composed of tubularly scrolled monolayer graphene and has shown superlubricity and large current sustainability, surpassing the properties of monolayer graphene itself. Here we report on the superior adhesion of GNS prepared with a high yield synthesis method that allows for mass production of high quality GNSs. Raman spectra indicate that the GNS still maintains the signature of monolayer graphene, implying the lacking of pi-stacking between adjacent layers. Importantly, adhesion measurements using atomic force microscopy reveal these GNSs with height range of 120-130 nm show a 2.5-fold stronger adhesion force than pristine graphene. This result potentially indicates that the GNS has higher adhesion than monolayer graphene and even higher than the liquid-solid and hydrogen-bonding enhanced interfaces which are essential types of adhesions involved in the field of physical adhesions and thus, GNS could be a new candidate for super-strong and lightweight devices.

  • Högström, Stig
    Östergarnsholm Översiktlig inventering av öns kärlväxter1988Report (Other academic)
    Abstract [sv]

    Östergarnsholm är aktuell som en av platserna för vindkraftverk på Gotland. Av denna anledning vill länsstyrelsen i Gotlands län in­ skaffa uppgifter om områdets natur. Jag fick i uppdrag av länssty­ relsen (1987-04-28, dnr 51.60-63-87) att utföra en översiktlig in­ ventering av öns kärlväxter. I det följande redovisas resultatet av inventeringen, vilken utfördes under våren och sommaren 1987.

  • Odolinski, Kristofer
    et al.
    Swedish National Road and Transport Research Institute, Society, environment and transport, Transport economics.
    Yarmukhamedov, Sherzod
    Riksrevisionen.
    Nilsson, Jan-Eric
    Swedish National Road and Transport Research Institute, Society, environment and transport, Transport economics.
    Haraldsson, Mattias
    Swedish National Road and Transport Research Institute, Society, environment and transport, Transport economics.
    The marginal cost of track reinvestments in the Swedish railway network: using data to compare methods2018Report (Other academic)
    Abstract [en]

    In this study, we analyze the difference between survival and corner solution models in estimating the marginal cost of reinvestments. Both approaches describe the reinvestment process in rather intuitively similar ways but have several methodological distinctions. We use Swedish railway data on track segment and section levels over the period 1999-2016 and focus on reinvestments in track superstructure. Results suggest the marginal costs from survival and corner solution models are SEK 0.0041 and SEK 0.0103, respectively. The conclusion is that the corner solution model is more appropriate, as this method consider the impact traffic has on the risk of reinvestment as well as on the size of the reinvestment cost. The survival approach does not consider the latter, which is problematic when we have systematic variations in costs due to traffic and infrastructure characteristics.

  • Janzon, Lars-Åke
    Status och skydd av rovstekeln Sphex rufocinctus: Inventeringar 19871988Report (Other academic)
    Abstract [sv]

    Länsstyrelsen i Gotlands län uppdrog åt mig att under 1987 inventera förekomsten av rovstekeln Sphex rufocinctus på lokaler där arten tidigare har förekommit.

    Inventeringen

    Jag anlände till Gotland den 20 juli och lämnade ön den 31 juli 1987.

    20 - 22.vii:  Gotland:  Ljugarn,  Folhammar,  Ard­ re, Sandvikens NR, Sjauster och Buttle.

    23 - 24.vii: Klintehamn, Lojsta, Tonnklint, Mäs­ termyr, Kvarnåkershamn, Mulde NR, Gnisvärd och Varvsholm.

    25 - 26.vii: Lärbro,  Tofta  skjutfält,                  Ireviken, Fardume träsk, Bäste träsk och Träskmyr.

    27  -31.vii:  Fårö:  St  Gåsemora,  Mölnor  träsk,

    Alnäsa träFårö  fyr,  Skalsand,  Ullahau, Sudersand, Vinor, Myrhaga myr, Holms udd, Lang­ hamrnar och Ajketräsk.

    Vamlingbo är den enda för Sphex tidigare kända lokalen som inte besöktes, och detta pga för dåligt väder.

     

     

  • Public defence: 2018-12-10 10:00 F3, Stockholm
    Rajput, Moeen ud din Saeed
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering.
    Damage Tolerance of Impacted Composite Sandwich Structures2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis deals with damage tolerance of impacted sandwich structures for load bearing applications. Composite sandwich structures find wide application as lightweight solutions in aerospace components, since weight reduction and less fuel emissions are primary concerns for aircraft manufactures. Sandwich structures are built of stiff face-sheet materials bonded to a low-density core material. In this thesis, the face-sheets are composite materials reinforced with carbon fibre non-crimp fabrics whereas the core consists of a closed cell foam material. Sandwich structures are susceptible to impact damage and even a small amount of damage can reduce the residual strength of components significantly. Therefore, damage tolerance assessment of such structures is essential and needs to be taken into account in the design process.

    Main objective of this thesis is assessment of test methodologies for estimation of compressive properties of foam core materials. An extensive experimental study of different densities of closed cell foam materials is presented and existing test standards are evaluated in this regard. Two different test methods were investigated for strain measurements of the foam material during compression testing assisted by a digital image correlation technique. A parametric study was also performed to investigate the effect of in-plane specimen size on the compressive modulus measurements. Both homogenized and stochastic finite element models are used to back the experimental observations. Different types of boundary conditions were used to simulate the effects of in-plane specimen size and prediction of compressive modulus. The findings were also used as basis for recommendations for updating current test standards.

    A part of the thesis work concerns the design and construction of a new drop-weight impact rig for low-velocity impact testing of sandwich structures. A test setup was designed to capture the true impact response without adulteration by oscillations. A novel catch mechanism was designed and implemented for preventing secondary impact. A detailed experimental evaluation and uncertainty analysis was also performed to evaluate the drop-weight rig in terms of repeatability and precision.

    The developed drop-weight rig was used to perform low-velocity impact characterization of sandwich structure with different face-sheet thicknesses. A range of impact energies were investigated for the identification of low level damage (LLD), barely visible impact damage (BVID) and visible impact damage (VID). A thorough fractography study was performed to understand the damage mechanisms at different energy levels and for different face thicknesses. A finite element model was developed to simulate the impact response and delamination extent, including both inter-laminar and intra-laminar damage modes.

    Finally, the impact damaged specimens were tested for damage tolerance assessment. Both symmetric and asymmetric specimen configurations with different face-sheet thicknesses were investigated. The effect of face-sheet thickness on the residual strength of sandwich structures was studied. Three different test methodologies for damage tolerance testing were investigated and the results were compared. A finite element model was developed for simulation of the edgewise compression test methods and the residual strength predictions were compared with the experimental results.

  • Johansson, Fredrik
    et al.
    Swedish National Road and Transport Research Institute, Society, environment and transport, Traffic analysis and logistics.
    Pyddoke, Roger
    Swedish National Road and Transport Research Institute, Society, environment and transport, Transport economics.
    Interaction delay and marginal cost in Swedish bicycle traffic2018Report (Other academic)
    Abstract [en]

    We apply the method presented by Johansson (2018) to estimate a volume delay function and marginal cost for bicycle traffic on cycling paths separated from motorized traffic based on point measurements of speed and lateral positions from seven sites in Sweden. The results indicate that a quadratic volume – delay function fits the data well in the observed range of volumes, and that there are significant delays already at volumes far below the capacity due to the heterogeneity of the desired speed over the population. The total marginal cost of delay per unit flow is estimated to €9×10-5 h/km.

  • Jansen, Philip
    et al.
    University of Twente, The Netherlands.
    Reijers, Wessel
    University of Twente, The Netherlands.
    Douglas, David
    University of Twente, The Netherlands.
    Sattarov, Faridun
    University of Twente, The Netherlands.
    Gurzawska, Agata
    University of Twente, The Netherlands.
    Kapeller, Alexandra
    University of Twente, The Netherlands.
    Brey, Philip
    University of Twente, The Netherlands.
    Benčin, Roc
    Scientific Research Centre of the Slovenian Academy of Sciences and Arts, Slovenia.
    Warso, Suzanna
    Helsi nki Foundation for Human Rights, Finland.
    Braun, Robert
    nstitute for Advanced Studies Vienna, Austira.
    SATORI A reasoned proposal for shared approaches to ethics assessment in the European context2017Report (Other academic)
    Abstract [en]

    This report presents a comprehensive proposal for a common ethics assessment framework for research and innovation (R&I) in the European Union member states. It details recommendations for good practices for ethics assessment, which includes the development of ethics assessment units and the protocols of these units. More specifically, the report presents a general toolkit for ethics assessment of R&I, as well as specialised tools and toolkits for specific types of organizations that deal with ethics assessment, and for different scientific fields. In addition, the report offers recommendations for the general institutional structure of ethics assessment in the EU and its member states. Due to the length of this report, a summary of its findings and recommendations is available. There are also several annexes that expand on particular sections of the report. These a nnexes are also available on the website of the SATORI project.

    In chapter 2, we analyse the stakeholders’ expectations about the intended outcome of the SATORI project: a shared European framework for ethics assessment of R&I. This analysis is based on 153 interviews with different kind s of stakeholders, including both et hics assessors and non - assessors. Both benefits and obstacles were identified and are listed in this chapter. Furthermore, three main challenges are identified: the differences in ethics/values, the need for stakeholder buy - in, and the need for the ethics assessment framework to be a long - term process. Nonetheless, it is found that a significant majority of interviewees were positive or conditionally positive towards the desirability of a common approach to ethics assessment in R&I.

    In chapter 3, we propose a framework of ethical issues and principles, which are applicable to a broad array of types of scientific R&I. The research areas discussed in depth are the natural sciences, the engineering sciences, and the medical and life sciences, information and communication technology (ICT), Internet research, the social sciences, and the humanities. It provides a basis of ethical issues and principles that apply to all types of research. It also specifies the principles and issues that apply to specific research contexts. This chapter also includes a section on how potential conflicts between ethical principles may be resolved.

    In chapter 4, we outline recommendations for best practice in Ethics Assessment Units (EAUs). These recommendations are structured around a series of parameters common to all EAUs that review R&I activity. These parameters include the appropriate composition of an EAU, the appointment, training, and expertise of its members, the procedures for performing assessment, and how to assess the quality and efficiency of the EAU’s work. The cultural and organisational factors that may affect the work of an EAU are also briefly considered. The chapter concludes with a summary of the recommendations presented within it.

    In chapter 5, we offer a short overview of the Common Framework for Ethical Impact Assessment (EIA) that is described further in Annex 1. This chapter can be used by governance bodies to set up new regulations with regard to ethics assessment in R&I , research funding organisations to set up new procedures for conducting EIAs in the projects they fund , and by local research organisations and companies for establishing internal procedures for conducting an EIA of the R&I projects they organise.

    In section 6, we present recommendations for specialised forms of ethics assessment and guidance. Specifically, we outline standards, tools and best practices for (1) policy - oriented assessment and guidance of new developments and practices in R&I (with a focus on governmental organisations, national ethics committees, and civil society organisations); (2) guiding, assessing and supporting ethical professional behaviour by scientists and innovators; an d (3) the ethics assessment of innovation and technology development plans.

    In chapter 7, we discuss ethics assessment (EA) and ethics guidance (EG) in the context of four specific types of organisation: universities, civil society organisations, industry and research funding organisations.

    In chapter 8, we outline proposals for the institutional structure of ethics assessment in eight types of organisations that perform ethics assessment in the EU member states: universities, national science academies, RFOs, RECs, NECs, academic and professional organisations, CSOs, and companies. In addition, we present recommendations for the institutionalisation of ethics assessment in selected European countries.

    I n chapter 9, we assess the compatibility of existing ethics assessment frameworks with the SATORI framework. This covers international regulations and guidelines as well as the approaches to ethics assessment in the United States and China.

    Finally, in chapter 10, we present a summary of the recommendations contained in this report, and conclude in chapter 11 with a list of the annexes to this report.  

  • Sandberg, Johanna
    Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
    Institutionally Shaped Response to the Introduction of National Guidelines: Case Studies in the Swedish Regional Health Policy Arena2018Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    The purpose of this thesis is to explore the institutionally shaped response to the introduction of the national guidelines on the Swedish regional health policy arena. The thesis consists of two case studies. Adapting a qualitative approach, the data is based on individual interviews and these were analysed thematically. The first paper explores the response by four Swedish regional health authorities to the introduction of the National Guidelines for Cardiac Care, while the second paper aims to broaden the understanding of how the national guidelines are used for strategic purposes among politicians.

    As illustrated in this thesis, organizations will respond, adjust and react to external pressure according to conditions shaped by the institutional context. Key findings here are that the national guidelines are a complex policy instrument that, beyond being able to be used in an instrumental fashion by the medical managment, can also serve a legitimizing function for political decision-makers.

    The goals of the national guidelines, i.e. equal and efficient care, and the uncertainty about who, among multiple stakeholders, is responsible for the guidelines in the regional health authority, is a source of ambiguity and potential conflict. Those who are potentially responsible represent different rationales – a political rationale and a scientific rationale. The dominating scientific rationale of the national guidelines can create instability, when pushing towards the use of explicit priority-setting.

    Priority-setting in the institutional setting of a regional health authority has strong elements of becoming “wicked problems” since the dilemma of prioritization remains regardless of ambitions to apply a “technocratic fix”. A wicked problem is characterized by high complexity and being persistently hard to solve (Williams et al. 2012). A recurring dilemma is that priority-setting still contains many wicked problems, as social values and political considerations remain important parts of the policy process. One weakness of the national guidelines, identified in this thesis, is that the guidelines discuss each service area separately, and thereby reinforce a silo mentality in the Swedish health policy arena.

    To sum up, the national guidelines create a multifaceted and complex response in the Swedish health policy arena where different rationalities collide, and where conflicts appear and are dealt with within the regional health authorities.

  • Johansson, Fredrik
    Swedish National Road and Transport Research Institute, Society, environment and transport, Traffic analysis and logistics.
    Estimating interaction delay in bicycle traffic from point measurements2018Report (Other academic)
    Abstract [en]

    Planning for bicycle traffic is getting increasingly popular in cities, often motivated by that it is beneficial for the environment and the public health, and that it is a space efficient mode of transport. However, research on bicycle traffic has traditionally focused mainly on safety and mode choice, and less on traffic engineering topics such as investigating travel times, delays, and capacities. This study contributes to filling this gap by presenting a general method to estimate a volume -- delay function for bicycle traffic based on point measurements of passage time, speed, and lateral position, and, using estimates of the value of time in bicycle traffic, estimating the marginal cost of the interaction delay.

    The proposed method is based on an established method to estimate the distribution of desired speeds, and extends this to estimate the delay of the observed cyclists. The method is demonstrated using a data set from a bridge in Stockholm, Sweden, showing that there is significant interaction delay and associated cost even for relatively modest volumes, implying that interaction delay and its cost should be considered when planning for bicycle traffic.

  • Broqvist, Karin
    et al.
    Magntorn, Ola
    Träd- och buskvegetationen på Stora Karlsö1989Report (Other academic)
    Abstract [sv]

    Denna skrift utgör ett avslutande självständigt arbete (prak­tikarbete II) inom den sista terminens kurs i naturvård på den treåriga biologisk-geovetenskapliga utbildningslinjen vid Stockholms universitet. Handledare från universitetet har va­ rit Bo Eknert.

    Inventeringen är utförd på uppdrag av länsstyrelsen i Got­ lands län och Karlsö Jagt- och Djurskyddsförenings AB.

    Syftet med inventeringen har varit att göra en så detaljerad kartläggning av Stora Karlsös träd- och buskvegetation att det i framtiden skall bli möjligt att konstatera om några förändringar har skett och hur stora dessa förändringar i så fall är.

    Iventeringen lägger tyngdpunkten på den mest expansiva arten på Stora Karlsö, nl!mligen enen. Följande rapport ger bl.a exempel på hur starkt enen expanderat på Stora Karlsö under 1900-talet.

    Fältarbetet är utfört under juni, juli och delar av augusti 1988.

    Vi vill tacka alla som bidragit med uppgifter av olika slag. Ejvind Rosen vid växtbiologiska institutionen vid Uppsala universitet och Rolf Jacobsson vid naturvårdsenheten vid länsstyrelsen i Uppsala har båda på ett fantastiskt sätt stöttat och hjälpt oss både i planeringsskedet och under fältarbetet på Stora Karlsö. Även Stellan Hedgren vid natur­ vårdsfunktionen vid länstyrelsen på Gotland och Karlsöklubben har hjälpt oss på alla sätt. Sist, men inte minst, vill vi tacka alla trevliga guider som arbetade på Stora Karlsö som­ maren 1988.

  • Public defence: 2018-12-05 13:00 B42, Uppsala
    Talibov, Vladimir O
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC.
    Interaction kinetic analysis in drug design, enzymology and protein research2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The work presented here is focused on the phenomenon of molecular recognition – the mutual ability of biological molecules to recognize each other through their chemical signatures. Here, the kinetic aspects of recognition were evaluated, as interaction kinetics reveal valuable dimensions in the description of molecular events in biological systems. The primary objects studied in this thesis were human proteins and their interaction partners. Proteins serve a fundamental role in living organisms, supporting the biochemical machinery by means of catalysis, signalling and transport; additionally, proteins are the main targets for drugs.

    In the first study, carbonic anhydrase (CA) isozymes were employed as a model system to address the problem of drug selectivity. Kinetic signatures preferable for the design of selective sulphonamide-based inhibitors were identified. In a follow up study, the recognition between CA and sulphonamides was separated into two parts, uncovering intrinsic recognition features that genuinely reflect the interaction mechanism. For the first time, the concept of intrinsic interaction kinetics was applied to a drug-target system.

    Another model protein studied in this thesis was calmodulin (CaM), as its interactions with other proteins should have specific kinetic signatures to support the dynamics of calcium-dependent signalling. The study evolved around calcium-dependent CaM interactions with the neuronal protein neurogranin (Ng), and revealed its complex nature. Ng was found to interact with CaM both in presence and absence of calcium, but with different kinetics and affinity. This finding supports development of a mechanistic model of calcium sensitivity regulation.

    The last two projects were more applied, exploring the druggability of an emerging class of pharmaceutical targets – epigenetic enzymes. Expertise and methodology for biophysically guided drug discovery towards histone demethylase LSD1 and histone methyltransferase SMYD3 were developed. For LSD1, the project assisted the rational design of active site-targeting macrocyclic peptides, and resulted in the development of competitive inhibitors with a well described mechanism of action. A novel biophysical platform for screening was developed for SMYD3. It proved to be successful, as it identified previously unknown allosteric ligand binding site. Both projects were supported by structural studies, expanding the druggable space of epigenetic targets.

  • Svantesson, Sven-I
    Grus och sand i Gotlands län1989Report (Other academic)
    Abstract [sv]

    Föreliggande rapport redovisar inventeringen av naturgrus, som utförts i Gotlands län undantaget nordligaste och sydligaste delen av ön (se fig. l).Inventeringen har skett inom ramen för det av riksdagen beslutade prog­ rammet för regionala inventeringar av grus och alternativa material (prop. 1981/82:220). Utredningen har omfattat översiktlig inventering av naturligt förekommande grus- och sandavlagringar.

    Inventeringen inleddes med litteratur- och arkivgenomgångar samt flygbilds­ tolkning i delar av området. Grus och sandavlagringarna undersöktes därefter i fält vad beträffar utbredning, uppbyggnad, materialsammansättning och geovetenskapligt skyddsvärde. Utförda laboratorieundersökningar av insamlade prov från en tidigare inventering, omfattande bestämning av bergartssamman­ sättning, har inarbetats i föreliggande inventering.

    Genom sammanvägning av kända skyddsvärden (geovetenskapligt, botaniskt, ornitologiskt, hydrogeologiskt värde, värde för landskapsbild och frilufts­ liv; se avsnitt 2:1) erhölls ett samlat naturvärde, vilket är indelat i tre naturvårdsklasser.

    De teoretiskt uttagbara volymerna i olika förekomster har uppskattats, lik­ som fördelningen i kornstorlekshänseende. Vid volymberäkningarna har hänsyn tagits till volymer "låsta" genom skyddsföreskrifter av olika slag samt låsta av bebyggelse och vägar (se avsnitt 2.1).

    Kortfattade uppgifter om de undersökta grusförekomsterna (114 st) redovisas i tabell 1, på kartklipp i skala 1:50 000 samt på en länskarta i skala 1:100 000 (bilaga 2). Grusförekomsterna beskrivs kortfattat i avsnitt 5.3.

    Resultatet av inventeringen visar, att det inom den inventerade delen av Gotland finns totalt ca 83 milj fm3 (m3 fast mått) sand och grus, varav dock endast ca 42 milj fm3 bedöms vara teoretiskt uttagbara. Ca 19 milj fm3 be­ döms bestå av grovkornigt material, ca 4 milj fm3 av växlande material, ca 16 milj fm3 av sand, och ca 3 milj fm3 har en okänd sammansättning. 22 st förekomster är synnerligen skyddsvärda från naturvårdssynpunkt (Klass I) och till naturvårdsklass II har 38 förekomster förts. Den teoretiskt uttagbara volymen i Klass Il-förekomster är ca 14,5 milj fm3 och i Klass III-förekomster ca 27,5 milj fm3.

    Förutsättningarna att finna grus och sand under grundvattenytan är i nästan samtliga grusförekomster dåliga, men i 17 förekomster har de bedömts vara måttliga. Endast i 5 förekomster har de bedömts vara goda, nämligen vid Svajde (6JNV:lll och 112), vid Västerhejde (6IN0:60), vid Slättflis (6IN0:70) och vid Langs hage (6IN0:80).

    Grusmaterialet i länets grusavlagringar domineras av sedimentära bergarter, i regel kalksten, och materialets hållfasthet är dålig. I vissa förekomster, främst på västra och nordvästra Gotland (se fig. 7), är dock halten av långtransporterade, hårda urbergarter i gruset tämligen hög i det att den överstiger 50% i några grusförekomster. Detta grus är det kvalitativt bästa grus som står att finna på Gotland.