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  • Olsson, Håkan
    et al.
    Executive, Myndigheter, Sveriges meteorologiska och hydrologiska institut, SMHI.
    Tengdelius-Brunell, Johanna
    Executive, Myndigheter, Sveriges meteorologiska och hydrologiska institut, SMHI.
    Avrinningsområden för vattenförekomster 2012: En hydrologisk indelning för PLC-62013Report (Other academic)
    Abstract [sv]

    Den här rapporten är ett uppdrag från HaV, Havs- och Vattenmyndigheten. Informationen i rapporten riktar sig, i första hand, till dem som inom SMED arbetar med Pollution Load Compilation 6 (PLC6), Vattenförvaltningen vid SMHI och till Vattenmyndigheterna. I rapporten redovisas resultatet av en aktivitet inom SMED där syftet var att definiera hydrologiska avrinningsområden för användning vid beräkning av flöden av vatten, kväve och fosfor till havet. Avrinningsområden för Vattenmyndigheternas vattenförekomster identifierades i digitala kartskikt från SVAR, Svenskt VattenARkiv vid SMHI. Från projektet har data leverats till andra utvecklingsprojekt inom SMED-vatten, till modelluppsättningen S-HYPE vid SMHI och till representanter för vattenmyndigheterna. Ett kartskikt med indelning i 27 831 områden var tillgängligt 26 november 2012. Kartskiktet kompletterades med information om flödesordning och identiteter för det havsområde som vattnet rinner till. Det kompletterade kartskiktet var tillgängligt för hämtning 21 december 2012. I början av 2013 gjordes ytterligare granskning av kartskikt och utkast till denna rapport. Det ledde till ytterligare förbättringar av kartskiktet till PLC6. I den här rapporten beskrivs kartskiktets innehåll.

    I slutet av 2012 gjordes korrigeringar av några vattenförekomsters identiteter och kartrepresentationer i SVAR. Dessa ändringar har införts i kartskiktet till PLC6 så att samordningen med vattenmyndigheternas vattenförekomster optimeras. Det här innebar att antalet områden i kartskiktet minskade till 27 830 eftersom två områden slogs samman. Det reviderade kartskiktet till PLC6 blev klart i mars 2013.

    Kartskiktet baseras på avrinningsområden från SVAR version 2012_2. Till den här versionen av vattendelare kunde vi koppla 23 127 av vattenmyndigheternas vattenförekomster i SVAR version 2012_2 inklusive ändringar av vattenförekomsters identiteter införda i SVAR i slutet av 2012. Av de här vattenförekomsterna var 1 103 preliminära, d.v.s. de var ännu inte fastställda av Vattenmyndigheterna. Det finns fler vattenförekomster för sjöar respektive vattendrag i SVAR men de ligger inte vid avrinningsområdenas utlopp.

  • Devine, Josefin
    [Review of:] Lars-Erik Edlund & Elzbieta Strzelecka (eds.) Mellannorrland i centrum, new edn (Umeå: Kungl. Skytteanska Samfundet , 2017)2017In: Journal of the English Place-Name Society, ISSN 1351-3095, Vol. 2016, no 48, p. 112-114Article, book review (Other academic)
  • Turner, David R.
    et al.
    Univ Gothenburg, Dept Marine Sci, BOX 461, SE-40530 Gothenburg, Sweden..
    Hassellöv, Ida-Maja
    Chalmers, Dept Mech & Maritime Sci, SE-41296 Gothenburg, Sweden..
    Ytreberg, Erik
    Chalmers, Dept Mech & Maritime Sci, SE-41296 Gothenburg, Sweden..
    Rutgersson, Anna
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Shipping and the environment: Smokestack emissions, scrubbers and unregulated oceanic consequences2017In: ELEMENTA-SCIENCE OF THE ANTHROPOCENE, ISSN 2325-1026, Vol. 5, article id 45Article in journal (Refereed)
    Abstract [en]

    While shipping has long been recognised as a very carbon-efficient transport medium, there is an increasing focus on its broader environmental consequences. The International Maritime Organisation is responsible for the regulation of ship emissions arising from fuel combustion. Their current regulations are, however, much less strict than those applying to land-based transport within the European Union. Five different groups of pollutant emission from ship smokestacks are addressed in this paper: sulphur oxides, nitrogen oxides, particulate matter, organic matter and metals. The reduction of sulphur oxide emissions into the atmosphere using scrubber technology adds another dimension to the discussion, as this approach results in focused discharge of some pollutants to the surface water. A scoping calculation shows that an open-loop scrubber on a medium-sized ship could discharge more copper and zinc daily to the surface water than the ship's antifouling paint. The use of antifouling paint in the European Union is subject to a prior risk assessment, but scrubber discharges are not subject to any such risk assessment. This situation presents a problem from the perspective of the Marine Strategy Framework Directive, as environmental monitoring programmes in some coastal areas of the Baltic Sea have shown that levels of both copper and zinc exceed environmental quality standards. To fulfil the Marine Strategy Framework Directive requirements and achieve Good Environmental Status, having knowledge of the magnitude of different anthropogenic pressures is important. Metal inputs from open-loop scrubbers have been largely neglected until now: some metals have the potential to serve as tracers for monitoring scrubber discharges.

  • Olsson, Håkan
    Executive, Myndigheter, Sveriges meteorologiska och hydrologiska institut, SMHI.
    Kvantifiering av fysisk påverkan på svenska vatten till följd av vattenuttag, flödesreglering och morfologiska förändringar: Slutrapport december 20042004Report (Other academic)
    Abstract [sv]

    Inom projektet sammanställdes information som kunde användas som indikatorer på

    fysisk påverkan enligt vattendirektivets intentioner. Det rörde sig om information som

    kunde specificeras geografiskt och som kunde tillgängliggöras under projekttiden.

    Målsättningen var att göra en första rikstäckande kartering av områden där det fanns

    vattenobjekt med indikation på kraftig fysisk påverkan.

    Vattenförekomster som är kraftigt fysiskt förändrade kan under vissa förutsättningar

    som specificeras i vattendirektivet bli karaktäriserade som ”preliminärt kraftigt

    modifierade vattenförekomster” (förkortas PKMV). Definitionen ”Kraftigt modifierade

    vatten” erhålls först sedan socio-ekonomiska tester utförts enligt artikel 4:3 i EU:s

    ramdirektiv för vatten. Dessa vattenförekomster får därmed mindre stränga miljömål. I

    projektarbetet identifierades 214 sjöar och 6 kustvattenområden som provisoriskt

    kraftigt modifierade. Inom 3265 delavrinningsområden fanns det i det insamlade

    underlaget indikation på förekomst av vatten som kan komma i fråga som PKMV (se

    karta på sidan 20 i denna rapport).

    Bedömningsunderlag, kartor och kartunderlag som producerats inom projektet lagrades

    vid SMHI för användning vid fortsatt arbete med karaktärisering av vattenförekomster

    inför rapporteringen till EU i mars 2005. Resultaten samlades också på en CD för

    leverans till Naturvårdsverket. I tabell 1 ges en översikt över information som

    sammanställts inom projektet.

    Tabell 1. Antal dokument, kartor och kartunderlag med data (shape-filer) som

    sammanställts i projektet och som rapporteras på CD. Kartor = kartbilder. Shape =

    shape-filer.

    Moment Kartor Shape Word-dok Övrigt

    Vattenuttag 5 1 1 4 av kartorna i Word-dok.

    Regleringsgrad 1

    Flödesindikatorer 1 1

    Flödesstatistik 1

    Regleringshöjd 1

    Sänkta sjöar 3 3

    Dammar 2

    Strandnära 4 4 1

    Hamnar 3 2

    Preliminärt kraftigt modifierade 6 3

    Preliminärt konstgjorda 2

    Slutrapport 1

    SUMMA 27 16 3

  • van der Burgt, Danielle
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Children's Spatialities: embodiment, emotion and agency2018In: Children's Geographies, ISSN 1473-3285, E-ISSN 1473-3277, Vol. 16, no 2, p. 218-219Article, book review (Other academic)
  • Nyström, Anna-Karin
    et al.
    SCB.
    Cooper, David
    Executive, Forskningsinstitut, IVL Swedish Environmental Research Institute.
    Use of data from the EU emission trading scheme for reporting to EU Monitoring Mechanism, UNFCCC and CLRTAP2005Report (Other academic)
    Abstract [en]

    In order to provide more accurate data for Sweden’s reporting to the EU Monitoring Mechanism, UNFCCC and CLRTAP, the potential of using emission trading data submitted by individual companies in a trading survey in 2004 has been investigated. In 2004 this work involved a quality check by comparing national Swedish data with data on fuel consumption and CO2 emissions reported in the trading survey on plant level for the yeas 1998-2004. In several cases, significant discrepancies were observed which warranted a closer investigation and an eventual revision of activity data and a few emission factors

    This present study covers an investigation of 46 plants with discrepancies in activity data and five plants with discrepancies in emission factors, discovered during the work in 2004. After consultation with the appropriate personnel at each company explanations to the observed differences were found. The results indicated a revision of the activity data, which have been performed for 35 plants. The investigation of emission factors also resulted in revision according to the table below. Previous CO2 factor used in submission 2005

    ton CO2/TJ

    New CO2 factor that will be used in submission 2006

    ton CO2/TJ

    Carbide furnace gas

    60

    145

    Refinery gas

    66.7

    59.3

    Petroleum coke

    103

    100

  • Nyström, Anna-Karin
    SCB.
    Study of differences in plant data between the Energy Statistics and the EU Emission Trading Scheme2007Report (Other academic)
    Abstract [en]

    In Sweden, about 700 plants are included in the European Union Emission Trading Scheme (ETS) for carbon dioxide (CO2), which was launched on the 1st of January 2005. The Swedish Environmental Protection Agency (EPA) is responsible for collecting and reviewing the data.

    For reporting of emissions to the UNFCCC, EU Monitoring Mechanism, CLRTAP and the EU NEC Directive 1990-2005, activity data is mainly based on energy statistics from Statistics Sweden’s quarterly fuel surveys (QS) and the industrial energy survey. In some cases, additional data sources, such as companies’ envi-ronmental reports or direct information from the companies, are used as a comple-ment.

    In 2006, a study was performed by SMED to verify plant specific data from the quarterly fuels statistics with data from the ETS. One recommendation in the study was to carry out an in-depth study focussing on a few plants with large differences between their QS and ETS data , which has now been carried out and the results are presented in this report.

    In this study the fossil energy amounts from 19 plants have been calculated in the ETS and compared with the energy amounts in the QS. Where differences were found the reasons were analysed comparing the levels of energy and fuel consump-tion by fuel type. Contacts have been made with a few plants to better understand the differences. Waste combustion is not included in the ETS and results show that the coherence is relatively good after waste combustion was excluded from the QS.

    The QS and the emission estimations that are made based on those data have a number of deficiencies. First of all, the reported fuel amount differs slightly be-tween the data sets and since ETS data are verified, they are likely to be more cor-rect. Besides, on plant level, the national thermal values and emission factors that are used for the GHG inventory is not totally correct. An other deficiency in the QS is that unconventional fuels are grouped in the QS into for instance "Other not specified fuels". The emission factors of these fuels are associated with very large uncertainties, since they are not specific for the current fuel and plant. Finally, another problem is that some of those unconventional fuels are incorrectly classi-fied. In the ETS some of these fuels are often partly biogenic and should hence be classified as "Other biomass".

    The deficiencies identified should be considered to be revised if a better coherence between the QS and the ETS is desired.

  • Hagen, Johannes
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics. Jonkoping Univ, Jonkoping Int Business Sch, Jonkoping, Sweden..
    The effects of increasing the normal retirement age on health care utilization and mortality2018In: Journal of Population Economics, ISSN 0933-1433, E-ISSN 1432-1475, Vol. 31, no 1, p. 193-234Article in journal (Refereed)
    Abstract [en]

    This essay estimates the health effects of increasing the normal retirement age using Swedish administrative data on drug prescriptions, hospitalizations, and mortality. To this end, I use a reform that raised the age at which broad categories of Swedish local government workers were entitled to retire with full pension benefits from 63 to 65. Estimating the effect of the reform on individuals' health within the age range 65-69, the results show no evidence that the reform impacted mortality or health care utilization. Increasing the normal retirement age may thus have positive government income effects without seriously affecting short to medium run government health care expenditures.

  • Agustsson, Atli
    et al.
    Univ Iceland, Sch Hlth Sci, Res Ctr Movement Sci, Reykjavik, Iceland..
    Sveinsson, Thorarinn
    Univ Iceland, Sch Hlth Sci, Res Ctr Movement Sci, Reykjavik, Iceland..
    Rodby-Bousquet, Elisabet
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Lund Univ, Orthopaed, Dept Clin Sci Lund, Lund, Sweden..
    The effect of asymmetrical limited hip flexion on seating posture, scoliosis and windswept hip distortion2017In: Research in Developmental Disabilities, ISSN 0891-4222, E-ISSN 1873-3379, Vol. 71, p. 18-23Article in journal (Refereed)
    Abstract [en]

    Background: Postural asymmetries with seating problems are common in adults with cerebral palsy.

    Aims: To analyse the prevalence of asymmetrical limited hip flexion (< 90) in adults with CP, and to evaluate the association between asymmetrical limited hip flexion and postural asymmetries in the sitting position.

    Methods and procedures: Cross-sectional data of 714 adults with CP, 16-73 years, GMFCS level I -V, reported to CPUP, the Swedish cerebral palsy national surveillance program and quality registry, from 2013 to 2015. Hip range of motion was analysed in relation to pelvic obliquity, trunk asymmetry, weight distribution, scoliosis and windswept hip distortion.

    Outcomes and results: The prevalence of asymmetrical limited hip flexion increased as GMFCS level decreased. Of adults at GMFCS level V, 22% had asymmetrical limited hip flexion (< 90). The odds of having an oblique pelvis (OR 2.6, 95% CI:1.6-2.1), an asymmetrical trunk (OR 2.1, 95% CI:1.1-4.2), scoliosis (OR 3.7, 95% CI:1.3-9.7), and windswept hip distortion (OR 2.6, 95% CI:1.2-5.4) were higher for adults with asymmetrical limited hip flexion compared with those with bilateral hip flexion > 90 degrees.

    Conclusions and implications: Asymmetrical limited hip flexion affects the seating posture and is associated with scoliosis and windswept hip distortion.

  • Styrket nordisk lovsamarbeid: Muligheter og utfordringer2018Other (Other (popular science, discussion, etc.))
    Abstract [no]

    Denne rapporten peker på utfordringer og muligheter for det nordiske lovsamarbeidet, som etter den nordiske samarbeidsavtalen (Helsingforsavtalen) er en sentral del i nordisk samarbeid. Rapporten har en rekke forslag til hvordan man kan styrke lovsamarbeidet.

    Rapporten fremhever at et styrket nordisk lovsamarbeid kan gi bedre lovgivning i hvert enkelt land, forebygge og motvirke grensehindre i Norden,og bidra til å fremheve den nordiske modellen i verdenssamfunnet. Et sterkere lovsamarbeid er viktig for å nå målet om at Norden skal være denmest integrerte region i verden i samsvar med de nordiske statsministrenes felles erklæring i 2016.

    Rapportforfatteren, professor emeritus Inge Lorange Backer ved Universitetet i Oslo, har lang erfaring fra nordisk samarbeid innenjustisområdet. Som ekspedisjonssjef i Lovavdelingen i Justisdepartementet i Norge (1995–2008) var han Norges medlem i den nordiske embetsmannskomiteen for lovsamarbeid.

  • Public defence: 2018-03-16 13:15 Auditorium Minus, Gustavianum, Uppsala
    Li, Oliver
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology, Studies in Faith and Ideologies, Philosophy of Religion.
    Panentheism, Panpsychism and Neuroscience: In Search of an Alternative Metaphysical Framework in Relation to Neuroscience, Consciousness, Free Will, and Theistic Beliefs2018Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This thesis philosophically examines, critically discusses, and proposes how a plausible philosophical framework of consciousness and free will should be formulated. This framework takes into account contemporary scientific research on human consciousness and free will and its possible challenges; also it is examined how this framework should be related to theistic beliefs – especially those connected to human and divine consciousness and free will.

    First, an overview of important research within the natural sciences about the conscious mind is presented together with its challenges to a theistic worldview. Next, questions related to reductive physicalism and dualism as a thesis and an antithesis are discussed. This dialectical approach leads to two lines for possible alternatives: emergence theories and process panpsychism. The subsequent analysis suggests that a form of process panpsychism in combination with a weaker form of emergence is most plausible.

    After a discussion of some central ideas about determinism and indeterminism, together with a brief overview of standard arguments within the philosophical free will debate, the proposed emergent process panpsychism is related to these standard arguments in the free will debate and scientific research about decision-making. As  a result it will be suggested how free will should be understood in relation to the emergent process panpsychism.

    The consequences of these results are then discussed in relation to a theistic worldview. Here panentheism will be suggested as the most reasonable conception of God. Also, the consequences for divine consciousness, divine action and interaction, the human soul, life before birth and after death, and more briefly a personal relationship with God, theological determinism, omniscience, and omnipotence will be discussed specifically in relation to panentheism in an emergent  process panpsychist setting.

  • Nyström, Anna-Karin
    SCB.
    Co2from the use of soda ash: CRF 2A42004Report (Other academic)
    Abstract [en]

    v

    Emissions of CO2 from the use of soda ash shall be reported to the UNFCCC according to the IPCC Guidelines. In earlier Submissions, Sweden has only reported emissions from the use of soda ash within glass manufacture. In this project contact has been made and data has been collected from several other users of soda ash, for instance moist snuff producers and producers of detergents. Data has also been collected from companies that reported use of soda ash in the trading survey sent by SEPA and SMED in January, and from the Swedish Chemicals Inspectorates (KemI). New calculations of CO2 from the use of soda ash were made for the time series 1990-2003 based on data from KemI for all sectors except from glass manufacturers, where the data already available from earlier submissions were used. The new time series show a lot higher emissions than in Submission 2004, but still CO2 emissions from the use of soda ash is only about 1 % of the total CO2 emissions in the Industrial Process sector.

  • Public defence: 2018-03-22 10:15 Sal IV, Uppsala
    Sakka, Laura Stavroula
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Affective responses to music in depressed individuals: Aesthetic judgments, emotions, and the impact of music-evoked autobiographical memories2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Music’s powerful influence on our affective states is often utilized in everyday life for emotion regulation and in music-therapeutic interventions against depression. Given this ability of music to influence emotions and symptoms in depressed people, it appears imperative to understand how these individuals affectively respond to music. The primary aim of this thesis is to explore whether depressed individuals have distinct affective responses to music, in terms of aesthetic judgments, emotional reactions, and emotion regulation. Furthermore, the thesis aims to provide possible explanations for such differences, in terms of underlying psychological processes (e.g., emotion-induction mechanisms) and depressive attributes (e.g., cognitive biases). Study I involves a music listening experiment exploring the relationship between depression and aesthetic judgments in music. Findings indicate that depression is associated with higher ratings of aesthetic judgment, accompanied by an enhanced reliance on the expressivity criterion. However, this relationship is not accompanied by an association between depression and the Openness to Experience personality factor. Study II investigates emotion regulation with music in depressed individuals, by means of a survey. The study features a novel conceptual framework for studying emotion regulation with music, grounded on the established process model of emotion regulation (Gross, 2008) in combination with the music-specific multi-level GSTM approach (van Goethem & Sloboda, 2011). Results indicate that depressed individuals do not differ from controls in their “active” emotional responding (i.e., emotion regulation) to music. Study III features an experiment comparing depressed to controls’ “passive” emotional responses (i.e., emotional reactions) to musical stimuli designed to activate specific mechanisms (i.e., Brain stem reflex, Contagion, and Episodic memory). Findings suggest that differences in emotional reactions occur with respect to episodic memory, potentially due to cognitive biases. Finally, Study IV follows up on these results and investigates the valence and specificity of music-evoked memories in depressed individuals. The study finds that depressed participants’ memories are negatively biased, but do not differ from controls’ in level of specificity. Together, the findings of this thesis suggest that music listening may have a dual potential for depressed individuals, functioning both as a beneficial resource for alleviating depressive symptoms (due to, e.g., elevated aesthetic appreciation of music) and as a contributing factor to depressive mood (due to, e.g., negatively biased memories).

  • Public defence: 2018-03-12 09:00 B/A1:111a, Uppsala
    van der Schot, Gijs
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular biophysics.
    Imaging Living Cells with an X-ray Laser2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Imaging living cells at a resolution higher than the resolution of optical microscopy is a significant challenge. Fluorescence microscopy can achieve a degree of super-resolution via labeling cellular components with a fluorescent dye. Reaching nanometer or sub-nanometer resolution requires high-energy radiation with significantly shorter wavelength than that of optical light. X-rays and electrons have the requisite wavelengths and could be suitable for such studies; however, these probes also cause significant radiation damage. A dose in excess of 100,000,000 Gray (Gy, J/kg) would be required to reach nanometer resolution on a cell, and no cell can survive this amount of radiation. As a consequence, much of what we know about cells at high resolution today comes from dead material.

    Theory predicts that an ultra-short and extremely bright coherent X-ray pulse from an X-ray free-electron laser can outrun key damage processes to deliver a molecular-level snapshot of a cell that is alive at the time of image formation. The principle of ‘diffraction before destruction’ exploits the difference between the speed of light (the X-ray pulse) and the much slower speed of damage formation. The femtosecond pulse ‘freezes’ motion in the cell at physiological temperatures on the time scale of atomic vibrations, offering unprecedented time resolution and a plethora of new experimental possibilities.

    This thesis describes the first test experiments on imaging living cells with an X-ray laser. I present results in three essential areas of live cell imaging. (i) We have used an aerosol injector to introduce live cyanobacteria into the X-ray focus, and recorded diffraction patterns with extremely low background at very high hit rates. (ii) We demonstrated scattered signal beyond 4 nm resolution in some of these experiments. (iii) The thesis also describes image reconstruction, using a new fully automated pipeline that I developed during my studies. The reconstruction of diffraction patterns was successful for all patterns that did not have saturated pixels. The new software suite, called RedFlamingo, selects exposures with desired properties, can sort them according to sample size, shape, orientation, exposure, the number and type of objects in the beam during the exposure, their distance from each other, and so forth. The software includes validation tools to assess the quality of the reconstructions.

  • Carlsson, Liselott
    Kristianstad University, Faculty of Education. Kristianstad University, Forskningsmiljön Arbete i skolan (AiS).
    På väg mot en tillgänglig utbildning för elever inom autism-spektrumtillstånd: en kvalitativ intervjustudie utifrån några informanters beskrivning av ett kommunövergripande skolutvecklingsprojekt2018Report (Other academic)
    Abstract [en]

    The aim of this study is based on a few informants’ descriptions andexperiences of the schools in a municipal school changed their workto increase inclusion for students with Autism Spectrum Disorders(ASD). The focus of the study is the changes which have been implemented,how it has influenced the student group's schooling andwhat success factors and challenges the school has encountered.According to the Swedish Education Act, shall the Swedish regularschool be available to all scholars. However, several studies and accountsshow that primary schools have found it difficult to meet theeducational needs of students with ASD. The national board of education(2009) and The Swedish schools inspectorate (2012) criticizingthe school for not investigating the students' needs and supplyadequate support.The study was conducted by a qualitative approach; data were collectedthrough semi-structured - and focus interviews. The choice touse interviews are based on interesting to let each informant describeshow their school, meet and educated students with ASD andwhat elements they consider important developments of an inclusiveschool for pupils with ASD.The implication of the results confirms that by increasing theknowledge about autism spectrum disorders of the instructors, theschool has developed a more including learning environment for thestudents. By creating, a flexible organization in the school’s studentsgives the chance to be in school on their own terms. Belonging to aclass on their own terms, with the possibility of instructing in differentcontexts, has increased the presence of many students.

  • Aaboud, M.
    et al.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    De Bruin, Pedro Sales
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Femtoscopy with identified charged pions in proton-lead collisions at root s(NN)=5.02 TeV with ATLAS2017In: Physical Review C: Covering Nuclear Physics, ISSN 2469-9985, E-ISSN 2469-9993, Vol. 96, no 6, article id 064908Article in journal (Refereed)
    Abstract [en]

    Bose-Einstein correlations between identified charged pions are measured for p+Pb collisions at root s(NN) = 5.02 TeV using data recorded by the ATLAS detector at the CERN Large Hadron Collider corresponding to a total integrated luminosity of 28 nb(-1). Pions are identified using ionization energy loss measured in the pixel detector. Two-particle correlation functions and the extracted source radii are presented as a function of collision centrality as well as the average transverse momentum (k(T)) and rapidity (y*(pi pi)) of the pair. Pairs are selected with a rapidity -2 < y*(pi pi) < 1 and with an average transverse momentum 0.1 < k(T) < 0.8 GeV. The effect of jet fragmentation on the two-particle correlation function is studied, and a method using opposite-charge pair data to constrain its contributions to the measured correlations is described. The measured source sizes are substantially larger in more central collisions and are observed to decrease with increasing pair k(T). A correlation of the radii with the local charged-particle density is demonstrated. The scaling of the extracted radii with the mean number of participating nucleons is also used to compare a selection of initial-geometry models. The cross term R-ol is measured as a function of rapidity, and a nonzero value is observed with 5.1 sigma combined significance for -1 < y*pi pi < 1 in the most central events.

  • Rujner, Hendrik
    et al.
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Architecture and Water.
    Leonhardt, Günther
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Architecture and Water.
    Marsalek, Jiri
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Architecture and Water.
    Perttu, Anna-Maria
    SENS Sustainable Energy Solutions, 12154 Nacka, Sweden.
    Viklander, Maria
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Architecture and Water.
    The effects of initial soil moistureconditions on swale flow hydrographs2018In: Hydrological Processes, ISSN 0885-6087, E-ISSN 1099-1085Article in journal (Refereed)
    Abstract [en]

    The effects of soil water content (SWC) on the formation of run‐off in grass swales draining into astorm sewer system were studied in two 30‐m test swales with trapezoidal cross sections. Swale1 was built in a loamy fine‐sand soil, on a slope of 1.5%, and Swale 2 was built in a sandy loam soil,on a slope of 0.7%. In experimental runs, the swales were irrigated with 2 flow rates reproducing run‐off from block rainfalls with intensities approximately corresponding to 2‐month and 3‐year events. Run‐off experiments were conducted for initial SWC (SWCini) ranging from 0.18 to 0.43 m3/m3. For low SWCini, the run‐off volume was greatly reduced by up to 82%, but at highSWCini, the volume reduction was as low as 15%. The relative swale flow volume reductions decreased with increasing SWCini and, for the conditions studied, indicated a transition of the dominating swale functions from run‐off dissipation to conveyance. Run‐off flow peaks were reduced proportionally to the flow volume reductions, in the range from 4% to 55%. The swale outflow hydrograph lag times varied from 5 to 15 min, with the high values corresponding tolow SWCini. Analysis of swale inflow/outflow hydrographs for high SWCini allowed estimations of the saturated hydraulic conductivities as 3.27 and 4.84 cm/hr in Swales 1 and 2, respectively. Such estimates differed from averages (N = 9) of double‐ring infiltrometer measurements (9.41 and 1.78 cm/hr). Irregularities in swale bottom slopes created bottom surface depression storage of 0.35 and 0.61 m3 for Swales 1 and 2, respectively, and functioned similarly as check bermscontributing to run‐off attenuation. The experimental findings offer implications for drainage swale planning and design: (a) SWCini strongly affect swale functioning in run‐off dissipation and conveyance during the early phase of run‐off, which is particularly important for design storms and their antecedent moisture conditions, and (b) concerning the longevity of swale operation, Swale 1 remains fully functional even after almost 60 years of operation, as judged from its attractive appearance, good infiltration rates (3.27 cm/hr), and high flow capacity.

  • Edueng, Khadijah
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy. Kulliyyah of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, Malaysia.
    Mahlin, Denny
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    Bergström, Christel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    The Need for Restructuring the Disordered Science of Amorphous Drug Formulations2017In: Pharmaceutical Research, ISSN 0724-8741, Vol. 34, no 9, p. 1754-1772Article, review/survey (Refereed)
    Abstract [en]

    The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of the attractive approaches to enhance solubility is via amorphization despite the stability issue associated with it. Although the number of amorphous-based research reports has increased tremendously after year 2000, little is known on the current research practice in designing amorphous formulation and how it has changed after the concept of solid dispersion was first introduced decades ago. In this review we try to answer the following questions: What model compounds and excipients have been used in amorphous-based research? How were these two components selected and prepared? What methods have been used to assess the performance of amorphous formulation? What methodology have evolved and/or been standardized since amorphous-based formulation was first introduced and to what extent have we embraced on new methods? Is the extent of research mirrored in the number of marketed amorphous drug products? We have summarized the history and evolution of amorphous formulation and discuss the current status of amorphous formulation-related research practice. We also explore the potential uses of old experimental methods and how they can be used in tandem with computational tools in designing amorphous formulation more efficiently than the traditional trial-and-error approach.

  • Mietala, Johanna
    SCB.
    Data om svenska fiskodlingar: Utveckling av metodik inför rapportering till HELCOM2012Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    Utgångspunkten för denna rapport är att undersöka huruvida data om svenska fisk-odlingar från den nuvarande populationen i SMP produktionsmässigt täcker den population som studeras i SCBs årliga Vattenbruksrapport. En andra frågeställning är hur väl de emissionsfaktorer som användes vid den förra rapporteringen av PLC Annual 2005 stämmer med data från miljörapporterna.

    Totala kväve- och fosforutsläpp samt produktionsdata jämförs mellan de två data-materialen i denna studie. Resultaten visar att 1) fosforutsläppen kommer att to-talskattas 10 % lägre och kväveutsläppen 29 % högre med produktionsdata från Vattenbruksrapporten och emissionsfaktorer jämfört med inrapporterade värden från SMP som enda datakälla 2) användning av emissionsfaktorer och produkt-ionsuppgifter från undersökningen Vattenbruk 2010 medför en underskattning på totalt fosforutsläpp om 11 % och en överskattning av kväveutsläppet med 36 % för de 31 anläggningar i SMP populationen där jämförelse varit möjlig på enskild fis-keodlingsnivå 3) jämförelser mellan produktionsdata angivet i miljörapporternas textdelar och produktionsdata för Vattenbruk 2010 är osäkra på grund av otillräck-lig information i textdelarna.

    Att kombinera uppgifter från de båda undersökningarna är såsom uppgifter om fiskodlingarna samlas in idag att rekommendera men kan uppskattas som mer tidskrävande än att endast använda sig av en av dessa uppgiftskällor. Detta ef-tersom datamaterialet behöver matchas på anläggningsnivå för att säkerställa emissionsfaktorernas relevans vid varje rapporteringstillfälle. Emellertid är detta även en tillgång eftersom statistiken blir mer finfördelad.

  • Aaboud, M.
    et al.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    De Bruin, Pedro Sales
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Search for direct top squark pair production in final states with two leptons in root s=13 TeV pp collisions with the ATLAS detector2017In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 77, no 12, article id 898Article in journal (Refereed)
    Abstract [en]

    The results of a search for direct pair production of top squarks in events with two opposite-charge leptons (electrons or muons) are reported, using 36.1 fb(-1) of integrated luminosity from proton-proton collisions at root s = 13 TeV collected by the ATLAS detector at the Large Hadron Collider. To cover a range of mass differences between the top squark (t) over tilde and lighter supersymmetric particles, four possible decay modes of the top squark are targeted with dedicated selections: the decay (t) over tilde -> b (chi) over tilde (+/-)(1) into a b-quark and the lightest chargino with (chi) over tilde (+/-)(1) W (chi) over tilde (0)(1),the decay (t) over tilde -> t (chi) over tilde (0)(1) into an on-shell top quark and the lightest neutralino, the three-body decay (t) over tilde -> bW (chi) over tilde (0)(1) and the four-body decay (t) over tilde -> bl nu(chi) over tilde (0)(1). No significant excess of events is observed above the Standard Model background for any selection, and limits on top squarks are set as a function of the (t) over tilde and (chi) over tilde (0)(1) masses. The results exclude at 95% confidence level (t) over tilde masses up to about 720 GeV, extending the exclusion region of supersymmetric parameter space covered by previous searches.

  • Nordström, Jan
    et al.
    Linköping University, Department of Mathematics, Computational Mathematics. Linköping University, Faculty of Science & Engineering.
    Frenander, Hannes
    Linköping University, Department of Mathematics, Computational Mathematics. Linköping University, Faculty of Science & Engineering.
    On Long Time Error Bounds for the Wave Equation on Second Order Form2018In: Journal of Scientific Computing, ISSN 0885-7474, E-ISSN 1573-7691Article in journal (Refereed)
    Abstract [en]

    Temporal error bounds for the wave equation expressed on second order form are investigated. We show that, with appropriate choices of boundary conditions, the time and space derivatives of the error are bounded even for long times. No long time bound on the error itself is obtained, although numerical experiments indicate that a bound exists.

  • Aaboud, M.
    et al.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    De Bruin, Pedro Sales
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Determination of the strong coupling constant alpha(s) from transverse energy-energy correlations in multijet events at root s=8 TeV using the ATLAS detector2017In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 77, no 12, article id 872Article in journal (Refereed)
    Abstract [en]

    Measurements of transverse energy-energy correlations and their associated asymmetries in multi-jet events using the ATLAS detector at the LHC are presented. The data used correspond to vs = 8 TeV proton-proton collisions with an integrated luminosity of 20.2 fb(-1). The results are presented in bins of the scalar sum of the transverse momenta of the two leading jets, unfolded to the particle level and compared to the predictions from Monte Carlo simulations. A comparison with next-to-leading-order perturbative QCD is also performed, showing excellent agreement within the uncertainties. From this comparison, the value of the strong coupling constant is extracted for different energy regimes, thus testing the running of alpha(s)(mu) predicted in QCD up to scales over 1 TeV. A global fit to the transverse energy-energy correlation distributions yields alpha(s)(m(Z)) = 0.1162 +/- 0.0011 (exp.)(-0.0070)(+0.0084) (theo.), while a global fit to the asymmetry distributions yields a value of alpha(s)(m(Z)) = 0.1196 +/- 0.0013 (exp.)(-0.0045)(+0.0075) (theo.).

  • Public defence: 2018-03-16 10:00 Q2, Stockholm
    Verginis, Christos
    KTH, School of Electrical Engineering and Computer Science (EECS), Automatic Control.
    Planning and Control of Cooperative Multi-Agent Manipulator-Endowed Systems2018Licentiate thesis, monograph (Other academic)
    Abstract [en]

    Multi-agent planning and control is an active and increasingly studied topic of research, with many practical applications, such as rescue missions, security, surveillance, and transportation. More specifically, cases that involve complex manipulator-endowed systems  deserve extra attention due to potential complex cooperative manipulation tasks and their interaction with the environment. This thesis addresses the problem of cooperative motion- and task-planning of multi-agent and multi-agent-object systems under complex specifications expressed as temporal logic formulas. We consider manipulator-endowed robotic agents that can coordinate in order to perform, among other tasks, cooperative object manipulation/transportation. Our approach is based on the integration of tools from the following areas: multi-agent systems, cooperative object manipulation, discrete abstraction design of multi-agent-object systems, and formal verification. More specifically, we divide the main problem into three different parts.The first part is devoted to the control design for the formation control of a team of rigid-bodies, motivated by its application to cooperative manipulation schemes. We propose decentralized control protocols such that desired position and orientation-based formation between neighboring agents is achieved. Moreover, inter-agent collisions and connectivity breaks are guaranteed to be avoided. In the second part, we design continuous control laws explicitly for the cooperative manipulation/transportation of an object by a team of robotic agents. Firstly, we propose robust decentralized controllers for the trajectory tracking of the object's center of mass.  Secondly, we design model predictive control-based controllers for the transportation of the object with collision and singularity constraints. In the third part, we design discrete representations of multi-agent continuous systems and synthesize hybrid controllers for the satisfaction of complex tasks expressed as temporal logic formulas. We achieve this by combining the results of the previous parts and by proposing appropriate trajectory tracking- and potential field-based continuous control laws for the transitions of the agents among the discrete states. We consider teams of unmanned aerial vehicles and mobile manipulators as well as multi-agent-object systems where the specifications of the objects are also taken into account.Numerical simulations and experimental results verify the claimed results.

  • Ajeani, Judith
    et al.
    Ayiasi, Richard Mangwi
    Tetui, Moses
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. Makerere University School of Public Health (MakSPH), Makerere University College of Health Sciences, Kampala, Uganda.
    Ekirapa-Kiracho, Elizabeth
    Namazzi, Gertrude
    Kananura, Rornald Muhumuza
    Kiwanuka, Suzanne Namusoke
    Beyeza-Kashesya, Jolly
    A cascade model of mentorship for frontline health workers in rural health facilities in Eastern Uganda: processes, achievements and lessons2017In: Global Health Action, ISSN 1654-9716, E-ISSN 1654-9880, Vol. 10, article id 1345497Article in journal (Refereed)
    Abstract [en]

    Background: There is increasing demand for trainers to shift from traditional didactic training to innovative approaches that are more results-oriented. Mentorship is one such approach that could bridge the clinical knowledge gap among health workers.

    Objectives: This paper describes the experiences of an attempt to improve health-worker performance in maternal and newborn health in three rural districts through a mentoring process using the cascade model. The paper further highlights achievements and lessons learnt during implementation of the cascade model.

    Methods: The cascade model started with initial training of health workers from three districts of Pallisa, Kibuku and Kamuli from where potential local mentors were selected for further training and mentorship by central mentors. These local mentors then went on to conduct mentorship visits supported by the external mentors. The mentorship process concentrated on partograph use, newborn resuscitation, prevention and management of Post-Partum Haemorrhage (PPH), including active management of third stage of labour, preeclampsia management and management of the sick newborn. Data for this paper was obtained from key informant interviews with district-level managers and local mentors.

    Results: Mentorship improved several aspects of health-care delivery, ranging from improved competencies and responsiveness to emergencies and health-worker professionalism. In addition, due to better district leadership for Maternal and Newborn Health (MNH), there were improved supplies/medicine availability, team work and innovative local problem-solving approaches. Health workers were ultimately empowered to perform better.

    Conclusions: The study demonstrated that it is possible to improve the competencies of frontline health workers through performance enhancement for MNH services using locally built capacity in clinical mentorship for Emergency Obstetric and Newborn Care (EmONC). The cascade mentoring process needed strong external mentorship support at the start to ensure improved capacity among local mentors to provide mentorship among local district staff.

  • Voniati, Chris
    et al.
    Vrije Universiteit Brussel, Belgium.
    Doudaki, Vaia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Carpentier, Nico
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media. Vrije Universiteit Brussel, Belgium.; Charles University, Prague, Czech Republic.
    Mapping community media organisations in Cyprus: A methodological reflection2018In: journal of alternative and community media, ISSN 2206-5857, Vol. 3, no 1, p. 17-35Article in journal (Refereed)
    Abstract [en]

    Identifying grassroots or ‘below-the-radar’ organisations, such as community media organisations, is a challenging task that is not always supported sufficiently by methodological literature. The objective of this article is to address this challenge by proposing a structured approach to mapping analysis: (1) driven by an (operational) definition of the social entity; (2) that allows for a population-based mapping process; (3) that uses a particular registration instrument (labelled a Mapping IndexCard, or MIC); (4) to process data from multiple sources; and (5) to analyse the information registered in these MICs. By zooming in on the only divided country of Europe – the island of Cyprus – this article then illustrates how to design and conduct a mapping research of community media organisations on a national scale. Other than giving an overview of the community media operating in Cyprus, this mapping exercise aims to provide a methodological guide for mapping civil society and  ‘below-the-radar’ organisations in general.

  • Sun, Xu
    et al.
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Zhang, Ganlin
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Nian, Jiayun
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.;Beijing Univ Chinese Med, Sch Grad, Beijing, Peoples R China..
    Yu, Mingwei
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Chen, Shijian
    Guangxi Med Univ, Dept Neurol, Affiliated Hosp 4, Liuzhou, Peoples R China..
    Zhang, Yi
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Yang, Guowang
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Yang, Lin
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Cheng, Peiyu
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Yan, Chen
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.;Beijing Univ Chinese Med, Sch Grad, Beijing, Peoples R China..
    Ma, Yunfei
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Meng, Hui
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.;Beijing Univ Chinese Med, Sch Grad, Beijing, Peoples R China..
    Wang, Xiaomin
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Li, Jin-Ping
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Elevated heparanase expression is associated with poor prognosis in breast cancer: a study based on systematic review and TCGA data2017In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 8, no 26, p. 43521-43535Article, review/survey (Refereed)
    Abstract [en]

    Heparanase promotes tumorigenesis, angiogenesis, and metastasis. Here, we conducted a study based on systematic review and the Cancer Genome Atlas (TCGA) data that examined heparanase expression in clinical samples to determine its prognostic value. According to the meta-analysis and TCGA data, we found that heparanase expression was up-regulated in most breast cancer specimens, and elevated heparanase expression was associated with increased lymph node metastasis, larger tumor size, higher histological grade, and poor survival. These results suggest that targeting heparanase might improve treatments for breast cancer patients.

  • Moustakas, Aristidis
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Garcia de Herreros, Antonio
    Inst Hosp del Mar Invest Med, Canc Res Program, Barcelona, Spain.;Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain..
    Epithelial-mesenchymal transition in cancer2017In: Molecular Oncology, ISSN 1574-7891, E-ISSN 1878-0261, Vol. 11, no 7, p. 715-717Article in journal (Other academic)
  • Sigrén, Peter
    University of Borås.
    Studentbarometern 20172018Report (Other academic)
    Abstract [sv]

    Studentbarometern omfattar två enskilda enkäter varav enkät I mäter åtta index genom 46 frågeställningar, ett index som avser upplevd stress (9 frågeställningar) samt ett index som avser hur nöjda studenterna är med att ha valt Högskolan i Borås för sina studier (3 frågeställningar). De åtta index som mäter utbildningsrelaterade områden är: utveckling av analytiska förmågor/färdigheter; pedagogisk kvalitet i undervisningen; huruvida kursvärderingar genomförs och diskuteras; om studentsamar­bete, i form av om grupparbeten leder till att studenterna utvecklar analy­tiska förmågor/färdigheter; hur informationen inför kursstart fungerar; att våga ge kritik utan att bli sämre behandlad; hur kravnivån upplevs på utbildningen; hur det administrativa stödet upplevs inom akademier och sektioner.

    Enkät II har sitt fokus på områden som hållbar utveckling; lika villkor; biblioteksverksamheten; studenthälsan samt Studentkårens arbete. 

  • Dølvik, Jon Erik
    et al.
    Jesnes, Kristin
    Nordic labour markets and the sharing economy: – Report from a pilot project2018Book (Refereed)
    Abstract [en]

    This report presents a preliminary knowledge status about implications of the sharing economy for labour markets and employment relations in the Nordic countries. It also reviews how the Nordic countries and their social partners approach the sharing economy and issues relating, amongst other, to its legality, regulation, taxation, and terms of competition. There is so far scant supply of statistics, data and research in this field. The employment potentials and consequences of the sharing economy will, amongst other, depend on the governments’ and the organized actors’ responses to these challenges. Currently, all the actors seem to be in a phase of knowledge gathering and deliberation of possible policy options, cautiously avoiding taking steps that might obstruct the development of the sharing economy.

  • Ólafsdóttir, Steingerður
    et al.
    Marniemi, Annikka
    Andersen, Morten C.
    Berg, Christina
    Prell, Hillevi
    Gísladóttir, Elva
    Helleve, Arnfinn
    Monitoring food marketing to children: A joint Nordic monitoring protocol for marketing of foods and beverages high in fat, salt and sugar (HFSS) towards children and young people2018Book (Other academic)
    Abstract [en]

    The protocol describes methods for how to monitor marketing of foods and beverages high in fat, salt and sugar towards children and young people at a given time as cross-sectional studies, as well as allowing for monitoring of trends. The data provided could also be used for evaluation purposes, for instance providing relevant data for evaluating regulation practices and schemes in the respective countries; to study advertising and marketing practices, contents and forms over time. In addition to being a tool for monitoring purposes within each country, the protocol will also enable comparisons between the Nordic countries by establishing a joint understanding on how each marketing channel should be monitored. The protocol has been developed as a Nordic project between representatives and experts from Iceland, Finland, Sweden, Denmark and Norway together with international experts.

  • Cronie, Ottmar
    Anton de Kom University of Suriname, Paramaribo, Suriname; Chalmers University of Technology, Göteborg.
    Likelihood Inference for a Functional Marked Point Process with Cox-Ingersoll-Ross Process MarksManuscript (preprint) (Other academic)
    Abstract [en]

    This paper considers maximum likelihood inference for a functional marked point process - the stochastic growth-interaction process - which is an extension of the spatio-temporal growth-interaction process to the stochastic mark setting. As a pilot study we here consider a particular version of this extended process, which has a homogenous Poisson process as unmarked point process and shifted independent Cox-Ingersoll-Ross processes as functional marks. These marks have supports determined by the lifetimes generated by an immigration-death process. By considering a (temporally) discrete sample scheme for the marks and by considering the process' alternative evolutionary representation as a multivariate diffusion (Markovian) with jumps, the likelihood function is expressed as a product of the process' closed form transition densities. Additionally, under the assumption that the mark processes are started in their common stationary distribution, and under some restrictions on the underlying parameters, consistency and asymptotic normality of the maximum likelihood (ML) estimators are proved. The ML-estimators derived from the stationarity assumption are then compared numerically to the ML-estimators derived under non-stationarity, in order to investigate the robustness of the stationarity assumption. To illustrate the model's use in forestry, it is fitted to a data set of Scots pines.

  • Cronie, Ottmar
    et al.
    Stochastics research group, CWIy, Amsterdam, The Netherlands.
    Mateu, Jorge
    Department of Mathematics, Universitat Jaume I, Campus Riu Sec, Castellón, Spain.
    Spatio-temporal càdlàg functional marked point processes: Unifying spatio-temporal frameworksManuscript (preprint) (Other academic)
    Abstract [en]

    This paper defines the class of càdlàg functional marked point processes (CFMPPs). These are (spatio-temporal) point processes marked by random elements which take values in a càdlàg function space, i.e. the marks are given by càdlàg stochastic processes. We generalise notions of marked (spatio-temporal) point processes and indicate how this class, in a sensible way, connects the point process framework with the random fields framework. We also show how they can be used to construct a class of spatio-temporal Boolean models, how to construct different classes of these models by choosing specific mark functions, and how càdlàg functional marked Cox processes have a double connection to random fields. We also discuss finite CFMPPs, purely temporally well-defined CFMPPs and Markov CFMPPs. Furthermore, we define characteristics such as product densities, Palm distributions and conditional intensities, in order to develop statistical inference tools such as likelihood estimation schemes.

  • Riede, Felix
    et al.
    Aarhus University, Denmark.
    Johannsen, Niels N.
    Aarhus University, Denmark.
    Högberg, Anders
    Linnaeus University, Faculty of Arts and Humanities, Department of Cultural Sciences. University of Johannesburg, South Africa ; Stellenbosch University, South Africa.
    Nowell, April
    University of Victoria, Canada.
    Lombard, Marlize
    University of Johannesburg, South Africa ; Stellenbosch University, South Africa.
    The role of play objects and object play in human cognitive evolution and innovation2018In: Evolutionary anthropology (Print), ISSN 1060-1538, E-ISSN 1520-6505, Vol. 27, no 1, p. 46-59Article in journal (Refereed)
    Abstract [en]

    In this contribution, we address a major puzzle in the evolution of human material culture: If matur-ing individuals just learn their parental generation’s material culture, then what is the origin of keyinnovations as documented in the archeological record? We approach this question by coupling alife-history model of the costs and benefits of experimentation with a niche-construction perspec-tive. Niche-construction theory suggests that the behavior of organisms and their modification ofthe world around them have important evolutionary ramifications by altering developmentalsettings and selection pressures. Part ofHomo sapiens’niche is the active provisioning of childrenwith play objects—sometimes functional miniatures of adult tools—and the encouragement ofobject play, such as playful knapping with stones. Our model suggests that salient material cultureinnovation may occur or be primed in a late childhood or adolescence sweet spot when cognitiveand physical abilities are sufficiently mature but before the full onset of the concerns and costsassociated with reproduction. We evaluate the model against a series of archeological cases andmake suggestions for future research.

  • Pajarillo, Edward Alain B.
    et al.
    Dankook University.
    Kim, Sang Hoon
    Dankook University.
    Valeriano, Valerie Diane
    Department of Animal Resources Science, Dankook University, Cheonan, South Korea.
    Lee, Ji Yoon
    Seoul National University.
    Kang, Dae-Kyung
    Dankook University.
    Proteomic View of the Crosstalk between Lactobacillus mucosae and Intestinal Epithelial Cells in Co-culture Revealed by Q Exactive-Based Quantitative Proteomics2017In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 8, article id 2459Article in journal (Refereed)
    Abstract [en]

    Lactobacilli are bacteria that are beneficial to host health, but information on communication between Lactobacilli and host cells in the intestine is lacking. In this study, we examined the proteomes of the Lactobacillus mucosae strain LM1, as a model of beneficial bacteria, and the intestinal porcine epithelial cell line (IPEC-J2) after co-culture. Label-free proteomics demonstrated the high-throughput capability of the technique, and robust characterization of the functional profiles and changes in the bacteria and intestinal cells was achieved in pure and mixed cultures. After co-culture, we identified totals of 376 and 653 differentially expressed proteins in the LM1 and IPEC-J2 proteomes, respectively. The major proteomic changes in the LM1 strain occurred in the functional categories of transcription, general function, and translation, whereas those in IPEC-J2 cells involved metabolic and cellular processes, and cellular component organization/biogenesis. Among them, elongation factor Tu, glyceraldehyde 3-phosphate dehydrogenase, and phosphocarrier protein HPr, which are known to be involved in bacterial adhesion, were upregulated in LM1. In contrast, proteins involved in tight junction assembly, actin organization, and genetic information processing (i.e., histones and signaling pathways) were significantly upregulated in IPEC-J2 cells. Furthermore, we identified functional pathways that are possibly involved in host–microbe crosstalk and response. These findings will provide novel insights into host–bacteria communication and the molecular mechanism of probiotic establishment in the intestine.

  • Beale, Colin
    et al.
    Department of Biology, University of York, Heslington, York, UK.
    Courtney Mustaphi, Colin
    York Institute for Tropical Ecosystems, Environment Department, University of York, Heslington, York, UK.
    Morrison, Thomas
    Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK.
    Archibald, Sally
    Centre for African Ecology, School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Natural Resources and the Environment, CSIR, Pretoria, South Africa.
    Anderson, T. Michael
    Department of Biology, Wake Forest University, Winston-Salem, North Carolina, USA.
    Dobson, Andrew
    Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
    Donaldson, Jason
    Centre for African Ecology, School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Johannesburg, South Africa.
    Hempson, Gaeth
    Centre for African Ecology, School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Johannesburg, South Africa.; South African Environmental Observation Network (SAEON), Ndlovu Node, Phalaborwa, Kruger National Park, South Africa.
    Probert, James
    Department of Earth, Ocean & Ecological Sciences, University of Liverpool, Liverpool, UK.
    Parr, Catherine
    Centre for African Ecology, School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Earth, Ocean & Ecological Sciences, University of Liverpool, Liverpool, UK.; Department of Zoology & Entomology, University of Pretoria, Pretoria, South Africa.
    Pyrodiversity interacts with rainfall to increase bird andmammal richness in African savannas2018In: Ecology Letters, ISSN 1461-023X, E-ISSN 1461-0248Article in journal (Refereed)
    Abstract [en]

    Fire is a fundamental process in savannas and is widely used for management. Pyrodiversity, variation in local fire characteristics, has been proposed as a driver of biodiversity although empirical evidence is equivocal. Using a new measure of pyrodiversity (Hempsonet al.), we undertook the first continent-wide assessment of how pyrodiversity affects biodiversity in protected areas across African savannas. The influence of pyrodiversity on bird and mammal species richness varied with rainfall: strongest support for a positive effect occurred in wet savannas (>650 mm/year), where species richness increased by 27% for mammals and 40% for birds in the most pyrodiverse regions. Range-restricted birds were most increased by pyrodiversity, suggesting the diversity of fire regimes increases the availability of rare niches. Our findings are significant because they explain the conflicting results found in previous studies of savannas. We argue that managing savanna landscapes to increase pyrodiversity is especially important in wet savannas.

  • Suh, Alexander
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology. University of Münster, Institute of Experimental Pathology (ZMBE).
    Bachg, Sandra
    University of Münster, Institute of Experimental Pathology (ZMBE).
    Donnellan, Stephen
    South Australian Museum, Adelaide; The University of Adelaide, School of Biological Sciences.
    Joseph, Leo
    National Research Collections Australia, CSIRO, Australian National Wildlife Collection.
    Brosius, Jürgen
    University of Münster, Institute of Experimental Pathology (ZMBE); Brandenburg Medical School (MHB).
    Kriegs, Jan Ole
    University of Münster, Institute of Experimental Pathology (ZMBE); Westfälisches Landesmuseum mit Planetarium, LWL-Museum für Naturkunde.
    Schmitz, Jürgen
    University of Münster, Institute of Experimental Pathology (ZMBE).
    De-novo emergence of SINE retroposons during the early evolution of passerine birds2017In: Mobile DNA, ISSN 1759-8753, E-ISSN 1759-8753, Vol. 8, article id 21Article in journal (Refereed)
    Abstract [en]

    Background: Passeriformes ("perching birds" or passerines) make up more than half of all extant bird species. The genome of the zebra finch, a passerine model organism for vocal learning, was noted previously to contain thousands of short interspersed elements (SINEs), a group of retroposons that is abundant in mammalian genomes but considered largely inactive in avian genomes.

    Results: Here we resolve the deep phylogenetic relationships of passerines using presence/absence patterns of SINEs. The resultant retroposon-based phylogeny provides a powerful and independent corroboration of previous sequence-based analyses. Notably, SINE activity began in the common ancestor of Eupasseres (passerines excluding the New Zealand wrens Acanthisittidae) and ceased before the rapid diversification of oscine passerines (suborder Passeri - songbirds). Furthermore, we find evidence for very recent SINE activity within suboscine passerines (suborder Tyranni), following the emergence of a SINE via acquisition of a different tRNA head as we suggest through template switching.

    Conclusions: We propose that the early evolution of passerines was unusual among birds in that it was accompanied by de-novo emergence and activity of SINEs. Their genomic and transcriptomic impact warrants further study in the light of the massive diversification of passerines.

  • Molochkov, Alexander
    et al.
    Far Eastern Fed Univ, Lab Phys Living Matter, Sukhanova 8, Vladivostok 690950, Russia..
    Begun, Alexander
    Far Eastern Fed Univ, Lab Phys Living Matter, Sukhanova 8, Vladivostok 690950, Russia..
    Niemi, Antti
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics. Univ Tours, Lab Math & Phys Theor, Federat Denis Poisson, France.; Beijing Inst Technol, Dept Phys, Beijing, Peoples R China..
    Gauge symmetries and structure of proteins2017In: XIITH QUARK CONFINEMENT AND THE HADRON SPECTRUM / [ed] Foka, Y Brambilla, N Kovalenko, V, E D P SCIENCES , 2017, article id UNSP 04004Conference paper (Refereed)
    Abstract [en]

    We discuss the gauge field theory approach to protein structure study, which allows a natural way to introduce collective degrees of freedom and nonlinear topological structures. Local symmetry of proteins and its breaking in the medium is considered, what allows to derive Abelian Higgs model of protein backbone, correct folding of which is defined by gauge symmetry breaking due hydrophobic forces. Within this model structure of protein backbone is defined by superposition of one-dimensional topological solitons (kinks), what allows to reproduce the three-dimensional structure of the protein backbone with precision up to 1A and to predict its dynamics.

  • Bunker, Aditi
    et al.
    Sewe, Maquins Odhiambo
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Sié, Ali
    Rocklöv, Joacim
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Sauerborn, Rainer
    Excess burden of non-communicable disease years of life lost from heat in rural Burkina Faso: a time series analysis of the years 2000-20102017In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 7, no 11, article id e018068Article in journal (Refereed)
    Abstract [en]

    Objectives: Investigate the association of heat exposure on years of life lost (YLL) from non-communicable diseases (NCD) in Nouna, Burkina Faso, between 2000 and 2010.

    Design: Daily time series regression analysis using distributed lag non-linear models, assuming a quasi-Poisson distribution of YLL.

    Setting: Nouna Health and Demographic Surveillance System, Kossi Province, Rural Burkina Faso.

    Participants: 18 367 NCD-YLL corresponding to 790 NCD deaths recorded in the Nouna Health and Demographic Surveillance Site register over 11 years.

    Main outcome measure: Excess mean daily NCD-YLL were generated from the relative risk of maximum daily temperature on NCD-YLL, including effects delayed up to 14 days.

    Results: Daily average NCD-YLL were 4.6, 2.4 and 2.1 person-years for all ages, men and women, respectively. Moderate 4-day cumulative rise in maximum temperature from 36.4 degrees C (50th percentile) to 41.4 degrees C (90th percentile) resulted in 4.44 (95% CI 0.24 to 12.28) excess daily NCDYLL for all ages, rising to 7.39 (95% CI 0.32 to 24.62) at extreme temperature (42.8 degrees C; 99th percentile). The strongest health effects manifested on the day of heat exposure (lag 0), where 0.81 (95% CI 0.13 to 1.59) excess mean NCD-YLL occurred daily at 41.7 degrees C compared with 36.4 degrees C, diminishing in statistical significance after 4 days. At lag 0, daily excess mean NCD-YLL were higher for men, 0.58 (95% CI 0.11 to 1.15) compared with women, 0.15 (95% CI -0.25 to 9.63) at 41.7 degrees C vs 36.4 degrees C.

    Conclusion: Premature death from NCD was elevated significantly with moderate and extreme heat exposure. These findings have important implications for developing adaptation and mitigation strategies to reduce ambient heat exposure and preventive measures for limiting NCD in Africa.

  • Eriksson, Jörgen
    et al.
    Lund University.
    Lagvik, Christer
    Uppsala University, University Library.
    Nolin, Emma
    Lund University.
    Moving towards open science? Conference report: the 9th Conference on Open Access Scholarly Publishing, Lisbon, September 20-21, 20172017In: Nordic Perspectives on Open Science, ISSN 2464-1839, Vol. 1Article in journal (Other academic)
    Abstract [en]

    The Conference on Open Access Scholarly Publishing, COASP, is held annually with the aim of reaching professional publishing organizations, independent publishers and university presses, as well as librarians, university administrators and other stakeholders. Here, we outline some themes and highlights from this year´s conference.

  • Dong, Zhihua
    et al.
    KTH Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden..
    Schonecker, Stephan
    KTH Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden..
    Chen, Dengfu
    Chongqing Univ, Coll Mat Sci & Engn, Chongqing 400030, Peoples R China..
    Li, Wei
    KTH Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden..
    Long, Mujun
    Chongqing Univ, Coll Mat Sci & Engn, Chongqing 400030, Peoples R China..
    Vitos, Levente
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. KTH Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden.;Wigner Res Ctr Phys, Res Inst Solid State Phys & Opt, POB 49, H-1525 Budapest, Hungary..
    Elastic properties of paramagnetic austenitic steel at finite temperature: Longitudinal spin fluctuations in multicomponent alloys2017In: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 96, no 17, article id 174415Article in journal (Refereed)
    Abstract [en]

    We propose a first-principles framework for longitudinal spin fluctuations (LSFs) in disordered paramagnetic (PM) multicomponent alloy systems and apply it to investigate the influence of LSFs on the temperature dependence of two elastic constants of PM austenitic stainless steel Fe15Cr15Ni. The magnetic model considers individual fluctuating moments in a static PM medium with first-principles-derived LSF energetics in conjunction with describing chemical disorder and randomness of the transverse magnetic component in the single-site alloy formalism and disordered local moment (DLM) picture. A temperature-sensitive mean magnetic moment is adopted to accurately represent the LSF state in the elastic-constant calculations. We make evident that magnetic interactions between an LSF impurity and the PM medium are weak in the present steel alloy. This allows gaining accurate LSF energetics and mean magnetic moments already through a perturbation from the static DLM moments instead of a tedious self-consistent procedure. We find that LSFs systematically lower the cubic shear elastic constants c' and c(44) by similar to 6 GPa in the temperature interval 300-1600 K, whereas the predominant mechanism for the softening of both elastic constants with temperature is the magneto-volume coupling due to thermal lattice expansion. We find that non-negligible local magnetic moments of Cr and Ni are thermally induced by LSFs, but they exert only a small influence on the elastic properties. The proposed framework exhibits high flexibility in accurately accounting for finite-temperature magnetism and its impact on the mechanical properties of PM multicomponent alloys.

  • Cornils, L.
    et al.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany..
    Kamlapure, A.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany..
    Zhou, L.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany.;Max Planck Inst Solid State Res, D-70569 Stuttgart, Germany..
    Pradhan, Saurabh
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Khajetoorians, A. A.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany.;Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands..
    Fransson, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Wiebe, J.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany..
    Wiesendanger, R.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany..
    Spin-Resolved Spectroscopy of the Yu-Shiba-Rusinov States of Individual Atoms2017In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 119, no 19, article id 197002Article in journal (Refereed)
    Abstract [en]

    A magnetic atom in a superconducting host induces so-called Yu-Shiba-Rusinov (YSR) bound states inside the superconducting energy gap. By combining spin-resolved scanning tunneling spectroscopy with simulations we demonstrate that the pair of peaks associated with the YSR states of an individual Fe atom coupled to an oxygen-reconstructed Ta surface gets spin polarized in an external magnetic field. As theoretically predicted, the electron and hole parts of the YSR states have opposite signs of spin polarizations which keep their spin character when crossing the Fermi level through the quantum phase transition. The simulation of a YSR state right at the Fermi level reveals zero spin polarization which can be used to distinguish such states from Majorana zero modes in chains of YSR atoms.

  • Garousi, Javad
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Lindbo, Sarah
    KTH Royal Inst Technol, Sch Biotechnol, Div Prot Technol, Stockholm, Sweden..
    Mitran, Bogdan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Buijs, Jos
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Vorobyeva, Anzhelika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Orlova, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Hober, Sophia
    KTH Royal Inst Technol, Sch Biotechnol, Div Prot Technol, Stockholm, Sweden..
    Comparative evaluation of tumor targeting using the anti-HER2 ADAPT scaffold protein labeled at the C-terminus with indium-111 or technetium-99m2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 14780Article in journal (Refereed)
    Abstract [en]

    ABD-Derived Affinity Proteins (ADAPTs) is a novel class of engineered scaffold proteins derived from an albumin-binding domain of protein G. The use of ADAPT6 derivatives as targeting moiety have provided excellent preclinical radionuclide imaging of human epidermal growth factor 2 (HER2) tumor xenografts. Previous studies have demonstrated that selection of nuclide and chelator for its conjugation has an appreciable effect on imaging properties of scaffold proteins. In this study we performed a comparative evaluation of the anti-HER2 ADAPT having an aspartate-glutamate-alanine-valine-aspartate-alanine-asparagine-serine (DEAVDANS) N-terminal sequence and labeled at C-terminus with (99)mTc using a cysteine-containing peptide based chelator, glycine-serine-serine-cysteine (GSSC), and a similar variant labeled with In-111 using a maleimido derivative of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator. Both (99)mTc-DEAVDANS-ADAPT6-GSSC and In-111-DEAVDANS-ADAPT6-GSSC-DOTA accumulated specifically in HER2-expressing SKOV3 xenografts. The tumor uptake of both variants did not differ significantly and average values were in the range of 19-21% ID/g. However, there was an appreciable variation in uptake of conjugates in normal tissues that resulted in a notable difference in the tumor-to-organ ratios. The In-111-DOTA label provided 2-6 fold higher tumor-to-organ ratios than (99)mTc-GSSC and is therefore the preferable label for ADAPTs.

  • Bah, Ibrahima
    et al.
    Univ Calif San Diego, La Jolla, USA; Johns Hopkins Univ, Baltimore, USA.
    Passias, Achilleas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Tomasiello, Alessandro
    Univ Milano Bicocca, Milan, Italy; INFN, Milan, Italy.
    AdS(5) compactifications with punctures in massive IIA supergravity2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 11, article id 050Article in journal (Refereed)
    Abstract [en]

    We find AdS(5) solutions holographically dual to compactifications of six-dimensional N=(1,0) supersymmetric field theories on Riemann surfaces with punctures. We simplify a previous analysis of supersymmetric AdS(5) IIA solutions, and with a suitable Ansatz we find explicit solutions organized in three classes, where an O8-D8 stack, D6- and D4-branes are simultaneously present, localized and partially localized. The D4-branes are smeared over the Riemann surface and this is interpreted as the presence of a uniform distribution of punctures. For the first class we identify the corresponding six-dimensional theory as an E-string theory coupled to a quiver gauge theory. The second class of solutions lacks D6-branes and its central charge scales as n(5/2), suggesting a five-dimensional origin for the dual field theory. The last class has elements of the previous two.

  • Aaboud, M.
    et al.
    Université Mohamed Premier, Faculté des Sciences; LPTPM, Oujda.
    Bergeås, Elin Kuutmann
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, M.F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, M.U.F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, P.H.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva.
    Search for a scalar partner of the top quark in the jets plus missing transverse momentum final state at √s=13 TeV with the ATLAS detector2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 12, article id 085Article in journal (Refereed)
    Abstract [en]

    A search for pair production of a scalar partner of the top quark in events with four or more jets plus missing transverse momentum is presented. An analysis of 36.1 fb(-1) of root s = 13 TeV proton-proton collisions collected using the ATLAS detector at the LHC yields no significant excess over the expected Standard Model background. To interpret the results a simplified supersymmetric model is used where the top squark is assumed to decay via (t) over tilde (1) -> t((*)) (chi) over tilde (0)(1) and (t) over tilde (1) -> b (chi) over tilde (+/-)(1) -> bW((*)) (chi) over tilde (0)(1), where (chi) over tilde (0)(1) ((chi) over tilde (+/-)(1) denotes the lightest neutralino (chargino). Exclusion limits are placed in terms of the top-squark and neutralino masses. Assuming a branching ratio of 100% to t (chi) over tilde (0)(1), top-squark masses in the range 450-1000 GeV are excluded for (chi) over tilde (0)(1) masses below 160 GeV. In the case where m((t) over tilde1) similar to m(t) + m((chi) over tilde 10), top-squark masses in the range 235-590 GeV are excluded.

  • Jabs, Verena
    et al.
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Edlund, Karolina
    Dortmund Univ, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany..
    Koenig, Helena
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Grinberg, Marianna
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Madjar, Katrin
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Rahnenfuehrer, Joerg
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Ekman, Simon
    Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden..
    Bergkvist, Michael
    Gavle Cent Hosp, Dept Oncol, Gavle, Sweden..
    Holmberg, Lars
    Reg Canc Ctr Uppsala Orebro, Uppsala, Sweden.;Kings Coll London, Fac Life Sci & Med, Div Canc Studies, London, England..
    Ickstadt, Katja
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Botling, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
    Hengstler, Jan G.
    Dortmund Univ, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany..
    Micke, Patrick
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
    Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 11, article id e0187246Article in journal (Refereed)
    Abstract [en]

    Non-small cell lung cancer (NSCLC) represents a genomically unstable cancer type with extensive copy number aberrations. The relationship of gene copy number alterations and subsequent mRNA levels has only fragmentarily been described. The aim of this study was to conduct a genome-wide analysis of gene copy number gains and corresponding gene expression levels in a clinically well annotated NSCLC patient cohort (n = 190) and their association with survival. While more than half of all analyzed gene copy number-gene expression pairs showed statistically significant correlations (10,296 of 18,756 genes), high correlations, with a correlation coefficient >0.7, were obtained only in a subset of 301 genes (1.6%), including KRAS, EGFR and MDM2. Higher correlation coefficients were associated with higher copy number and expression levels. Strong correlations were frequently based on few tumors with high copy number gains and correspondingly increased mRNA expression. Among the highly correlating genes, GO groups associated with posttranslational protein modifications were particularly frequent, including ubiquitination and neddylation. In a meta-analysis including 1,779 patients we found that survival associated genes were overrepresented among highly correlating genes (61 of the 301 highly correlating genes, FDR adjusted p<0.05). Among them are the chaperone CCT2, the core complex protein NUP107 and the ubiquitination and neddylation associated protein CAND1. In conclusion, in a comprehensive analysis we described a distinct set of highly correlating genes. These genes were found to be overrepresented among survival-associated genes based on gene expression in a large collection of publicly available datasets.

  • Holm, Lena
    et al.
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies.
    Larsson, Thomas B.
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies.
    Gravrösen i Norrland2018Report (Other academic)
  • Al-Douri, Yamur
    et al.
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Operation, Maintenance and Acoustics.
    Hamodi, Hussan
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Operation, Maintenance and Acoustics.
    Data imputing using genetic algorithms (GA): A case study of cost data for tunnel fans2017Conference paper (Refereed)
  • Ali, Abir Salwa
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology.
    Grönberg, Malin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology.
    Federspiel, Birgitte
    Rigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark.
    Scoazec, Jean-Yves
    Inst Gustave Roussy, Villejuif, France.
    Hjortland, Geir Olav
    Univ Oslo, Oslo, Norway.
    Gronbaek, Henning
    Aarhus Univ Hosp, Aarhus, Denmark.
    Ladekarl, Morten
    Aarhus Univ Hosp, Aarhus, Denmark.
    Langer, Seppo W.
    Rigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark.
    Welin, Staffan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology.
    Vestermark, Lene Weber
    Odense Univ Hosp, Odense, Denmark.
    Arola, Johanna
    Univ Helsinki, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland.
    Osterlund, Pia
    Univ Helsinki, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland; Tampere Univ Hosp, Tampere, Finland.
    Knigge, Ulrich
    Univ Copenhagen, Rigshosp, Copenhagen, Denmark.
    Sorbye, Halfdan
    Haukeland Hosp, Bergen, Norway; Univ Bergen, Bergen, Norway.
    Grimelius, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Tiensuu Janson, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology. Uppsala Univ, Sect Endocrine Oncol, Dept Med Sci, Uppsala, Sweden..
    Expression of p53 protein in high-grade gastroenteropancreatic neuroendocrine carcinoma2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 11, article id e0187667Article in journal (Refereed)
    Abstract [en]

    Background Gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs) are aggressive, rapidly proliferating tumors. Therapeutic response to current chemotherapy regimens is usually short lasting. The aim of this study was to examine the expression and potential clinical importance of immunoreactive p53 protein in GEP-NEC. Materials and methods Tumor tissues from 124 GEP-NEC patients with locally advanced or metastatic disease treated with platinum-based chemotherapy were collected from Nordic centers and clinical data were obtained from the Nordic NEC register. Tumor proliferation rate and differentiation were re-evaluated. All specimens were immunostained for p53 protein using a commercially available monoclonal antibody. Kaplan-Meier curves and cox regression analyses were used to assess progression-free survival (PFS) and overall survival (OS). Results All tumor tissues were immunoreactive for either one or both neuroendocrine biomarkers (chromogranin A and synaptophysin) and Ki67 index was >20% in all cases. p53 immunoreactivity was only shown in 39% of the cases and was not found to be a prognostic marker for the whole cohort. However, p53 immunoreactivity was correlated with shorter PFS in patients with colorectal tumors (HR = 2.1, p = 0.03) in a univariate analysis as well as to poorer PFS (HR = 2.6, p = 0.03) and OS (HR = 3.4, p = 0.02) in patients with colorectal tumors with distant metastases, a correlation which remained significant in the multivariate analyses. Conclusion In this cohort of GEP-NEC patients, p53 expression could not be correlated with clinical outcome. However, in patients with colorectal NECs, p53 expression was correlated with shorter PFS and OS. Further studies are needed to establish the role of immunoreactive p53 as a prognostic marker for GEP-NEC patients.

  • Pool, Sandra
    et al.
    Univ Zurich, Zurich, Switzerland.
    Vis, Marc J. P.
    Univ Zurich, Zurich, Switzerland.
    Knight, Rodney R.
    US Geol Survey, Nashville, USA.
    Seibert, Jan
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL. Univ Zurich, Zurich, Switzerland; Stockholm Univ, Stockholm, Sweden.
    Streamflow characteristics from modeled runoff time series importance of calibration criteria selection2017In: Hydrology and Earth System Sciences, ISSN 1027-5606, E-ISSN 1607-7938, Vol. 21, no 11, p. 5443-5457Article in journal (Refereed)
    Abstract [en]

    Ecologically relevant streamflow characteristics (SFCs) of ungauged catchments are often estimated from simulated runoff of hydrologic models that were originally calibrated on gauged catchments. However, SFC estimates of the gauged donor catchments and subsequently the ungauged catchments can be substantially uncertain when models are calibrated using traditional approaches based on optimization of statistical performance metrics (e.g., Nash-Sutcliffe model efficiency). An improved calibration strategy for gauged catchments is therefore crucial to help reduce the uncertainties of estimated SFCs for ungauged catchments. The aim of this study was to improve SFC estimates from modeled runoff time series in gauged catchments by explicitly including one or several SFCs in the calibration process. Different types of objective functions were defined consisting of the Nash-Sutcliffe model efficiency, single SFCs, or combinations thereof. We calibrated a bucket-type runoff model (HBV-Hydrologiska Byrans Vattenavdelning-model) for 25 catchments in the Tennessee River basin and evaluated the proposed calibration approach on 13 ecologically relevant SFCs representing major flow regime components and different flow conditions. While the model generally tended to underestimate the tested SFCs related to mean and high-flow conditions, SFCs related to low flow were generally overestimated. The highest estimation accuracies were achieved by a SFC-specific model calibration. Estimates of SFCs not included in the calibration process were of similar quality when comparing a multi-SFC calibration approach to a traditional model efficiency calibration. For practical applications, this implies that SFCs should preferably be estimated from targeted runoff model calibration, and modeled estimates need to be carefully interpreted.

  • Liao, Qinghua
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Pabis, Anna
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular biophysics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Strodel, Birgit
    Forschungszentrum Julich, Julich, Germany; Heinrich Heine Univ Dusseldorf, Dusseldorf, Germany.
    Kamerlin, Shina Caroline Lynn
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Biology.
    Extending the Nonbonded Cationic Dummy Model to Account for Ion-Induced Dipole Interactions2017In: Journal of Physical Chemistry Letters, ISSN 1948-7185, E-ISSN 1948-7185, Vol. 8, no 21, p. 5408-5414Article in journal (Refereed)
    Abstract [en]

    Modeling metalloproteins often requires classical molecular dynamics (MD) simulations in order to capture their relevant motions, which in turn necessitates reliable descriptions of the metal centers involved. One of the most successful approaches to date is provided by the "cationic dummy model", where the positive charge of the metal ion is transferred toward dummy particles that are bonded to the central metal ion in a predefined coordination geometry. While this approach allows for ligand exchange, and captures the correct electrostatics as demonstrated for different divalent metal ions, current dummy models neglect ion-induced dipole interactions. In the present work, we resolve this weakness by taking advantage of the recently introduced 12-6-4 type Lennard-Jones potential to include ion-induced dipole interactions. We revise our previous dummy model for Mg2+ and demonstrate that the resulting model can simultaneously reproduce the experimental solvation free energy and metal ligand distances without the need for artificial restraints or bonds. As ion-induced dipole interactions become particularly important for highly charged metal ions, we develop dummy models for the biologically relevant ions Al3+, Fe3+, and Cr3+. Finally, the effectiveness of our new models is demonstrated in MD simulations of several diverse (and highly challenging to simulate) metalloproteins.