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  • Forsell, Karl
    et al.
    Department of Occupational and Environmental Medicine, Sahlgrenska Academy, Gothenburg.
    Björ, Ove
    Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
    Järvholm, Bengt
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Nilsson, Ralph
    Department of Occupational and Environmental Medicine, Sahlgrenska Academy, Gothenburg.
    Andersson, Eva
    Department of Occupational and Environmental Medicine, Sahlgrenska Academy, Gothenburg.
    Hematologic malignancy in tanker crewmembers: A case-referent study among male Swedish seafarers2020In: American Journal of Industrial Medicine, ISSN 0271-3586, E-ISSN 1097-0274Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Work on Swedish petroleum tankers before the late 1980s has been associated with an increased risk of hematologic malignancy (HM). Since then, ship modernizations have decreased occupational exposure to gases, including the carcinogen benzene. We explored the risk of HMs in Swedish seafarers who had worked on newer types of tankers.

    METHODS: A case-referent study in male seafarers from a cohort of all Swedish seafarers was set up by record linkage with the Swedish Cancer Registry using the subjects' personal identification number. For each case (N = 315), five referents were randomly chosen from within the cohort, matched by birth year and three different periods of first sea service (<1985, 1985-1991, and ≥1992). Information on the type of ship and dates of service was retrieved from the Swedish Seafarers' Registry. Odds ratios (OR) were calculated by conditional logistic regression together with 95% confidence intervals (CI).

    RESULTS: The OR of HM was 1.07 (95% CI, 0.80-1.42) for work on tankers. In seafarers that had started to work on tankers ≥1985, the OR was 0.85 (95% CI, 0.50-1.43). For those who started to work on tankers before 1985, the OR was 1.17 (95% CI, 0.84-1.21) and 1.32 (95% CI, 0.86-2.03) if the cumulative time on tankers exceeded 5 years of service. In this last group, the OR of multiple myeloma was 5.39 (95% CI, 1.11-26.1).

    CONCLUSION: Although limited by crude exposure contrast and a short follow-up, work on tankers after 1985 was not associated with an increased risk of HM among Swedish seafarers.

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  • Jansson, Maria
    Stockholm University, Faculty of Social Sciences, Department of Political Science.
    Gustafsson Sofie: Medborgarskapande på olika villkor. Självbilder, skolkoder och syn på kunskap i den svenska gymnasieskolan.: Anmälan av Maria Jansson2017In: Statsvetenskaplig Tidskrift, ISSN 0039-0747, Vol. 119, no 2, p. 341-345, article id 16963Article, book review (Other academic)
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  • Colding, Johan
    et al.
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science. Beijerinstitutet för Ekologisk Ekonomi, KVA.
    Gren, Åsa
    KTH.
    Barthel, Stephan
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science. Stockholm Resilience Centre, Stockholm University.
    The Incremental Demise of Urban Green Spaces2020In: Land, ISSN 2073-445X, E-ISSN 2073-445X, Vol. 9, no 5Article in journal (Refereed)
    Abstract [en]

    More precise explanations are needed to better understand why public green spaces are diminishing in cities, leading to the loss of ecosystem services that humans receive from natural systems. This paper is devoted to the incremental change of green spaces—a fate that is largely undetectable by urban residents. The paper elucidates a set of drivers resulting in the subtle loss of urban green spaces and elaborates on the consequences of this for resilience planning of ecosystem services. Incremental changes of greenspace trigger baseline shifts, where each generation of humans tends to take the current condition of an ecosystem as the normal state, disregarding its previous states. Even well-intended political land-use decisions, such as current privatization schemes, can cumulatively result in undesirable societal outcomes, leading to a gradual loss of opportunities for nature experience. Alfred E. Kahn referred to such decision making as ‘the tyranny of small decisions.’ This is mirrored in urban planning as problems that are dealt with in an ad hoc manner with no officially formulated vision for long-term spatial planning. Urban common property systems could provide interim solutions for local governments to survive periods of fiscal shortfalls. Transfer of proprietor rights to civil society groups can enhance the resilience of ecosystem services in cities.

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  • Colding, Johan
    et al.
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science. Beijerinstitutet för Ekologisk Ekonomi, KVA.
    Wallhagen, Marita
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science.
    Sörqvist, Patrik
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science.
    Marcus, Lars
    Chalmers University of Technology.
    Hillman, Karl
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science.
    Samuelsson, Karl
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science.
    Barthel, Stephan
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science. Stockholm Resilience Centre, Stockholm University.
    Applying a Systems Perspective on the Notion of the Smart City2020In: Sustainability, ISSN 2071-1050, E-ISSN 2071-1050, Vol. 3, article id 22Article in journal (Refereed)
    Abstract [en]

    This paper focuses on the need for a widened definition of the notion of technology within the smart city discourse, with a particular focus on the “built environment”. The first part of the paper describes how current tendencies in urban design and architecture are inclined to prioritize high tech-solutions at the expense of low-tech functionalities and omits that information and communication technology (ICT) contrasts the art of building cities as an adaptable and habitually smart technology in itself. It continues with an elaboration on the need for expanding the limits of system boundaries for a better understanding of the energy and material telecouplings that are linked to ICT solutions and account for some perils inherent in smart technologies, such as rebound effects and the difficulty of measuring the environmental impacts of ICT solutions on a city level. The second part of the paper highlights how low-tech technologies and nature-based solutions can make cities smarter, representing a new technology portfolio in national and international policies for safeguarding biodiversity and the delivery of a range of ecosystem services, promoting the necessary climate-change adaption that cities need to prioritize to confer resilience.

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  • Sigrén, Peter
    University of Borås.
    Kvalitet inom högre utbildning: Hur upplever studenter kvaliteten på sin utbildning?2020Report (Other academic)
    Abstract [sv]

    Före­liggande rapport redovisar resultat från fem studentbarometrar utförda mellan år 2015 och 2019. Syftet med dessa studier är att doku­mentera och förankra, upplevda av studenter, kvalitetsdimensioner inom lärosätets utbildnings­verksam­heter. 30 670 studenter haft möjlighet att besvara två webbaserade frågeformulär. Fördelningen mellan dessa enkäter är 15 335 studenter (2015-2019) per enkät. 4 761 studenter har besvarat enkät 1 och 2 661 har besvarat enkät 2. Ett antal index har utkristallise­rats som mäter studenters upplevda kvalitet inom områden som hör en högsko­le­utbildning till. Föreliggande studie redovisar åtta kvalitetsindex, två index som mäter djup- och ytinlärnings­strategier, ett index som mäter stress, ett index som mäter studenters renommé för utbildningen samt ett Nöjd Student Index (NSI). Övriga områden som redovisas är hållbar utveckling, lika villkor samt högskolans biblioteksverksamhet.

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  • Colding, Johan
    et al.
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science. Beijerinstitutet för Ekologisk Ekonomi, KVA.
    Giusti, Matteo
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science.
    Haga, Andreas
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science.
    Wallhagen, Marita
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science.
    Barthel, Stephan
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building Engineering, Energy Systems and Sustainability Science, Environmental Science. Stockholm Resilience Centre, Stockholms universitet.
    Enabling Relationships with Nature in Cities2020In: Sustainability, ISSN 2071-1050, E-ISSN 2071-1050, Vol. 12, article id 4394Article in journal (Refereed)
    Abstract [en]

    Limited exposure to direct nature experiences is a worrying sign of urbanization, particularly for children. Experiencing nature during childhood shapes aspects of a personal relationship with nature, crucial for sustainable decision-making processes in adulthood. Scholars often stress the need to ‘reconnect’ urban dwellers with nature; however, few elaborate on how this can be achieved. Here, we argue that nature reconnection requires urban ecosystems, with a capacity to enable environmental learning in the cognitive, affective and psychomotor domains, i.e., learning that occurs in the head, heart and hands of individuals. Drawing on environmental psychology, urban ecology, institutional analysis and urban planning, we present a theoretical framework for Human–Nature Connection (HNC), discuss the importance of nurturing HNC for children, elaborate on the role of property-rights and the importance of creating collective action arenas in cities for the promotion of urban resilience building. As values and environmental preconceptions underly environmental behavior, there are limits to achieving HNC in cities, as presumptive sentiments toward nature not always are positive. We end by discussing the role of new digital technologies in relation to HNC, and conclude by summarizing the major points brought forward herein, offering policy recommendations for HNC as a resilience strategy that can be adopted in cities throughout the world.

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  • Public defence: 2020-06-11 10:00 https://kth-se.zoom.us/j/67826970577 , Vid fysisk närvaro eller Du som saknar dator/datorvana kan kontakta service@itm.kth.se
    Arzpeyma, Niloofar
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering.
    Model Developments to Study Some Aspects of Improving Efficiencies in EAF Plants2020Doctoral thesis, monograph (Other academic)
    Abstract [en]

    The aim of this thesis is to investigate some aspects of improvements with respect to the energy consumption and raw material selection as well as the understanding of the influence of uncertainties on the performance in electric arc furnace (EAF) plants. The effect of electromagnetic stirring on the scrap melting and post combustion capacity are investigated in two EAFs by using computation fluid dynamic (CFD) models. The results showed that electromagnetic stirring can contribute to a better heat transfer rate at the melt – scrap interface. The Grashof and Nusselt numbers for both electromagnetic stirring and natural convection were estimated, as well as compared to the data from previous studies. Also, the results of the post-combustion in the duct system were used to predict the concentration of uncombusted CO at the possible position to install an off – gas analysis equipment. Also, modeling of the post-combustion in the whole furnace showed that the post-combustion can be improved by increasing the flow rate of the secondary oxygen in a virtual lance burner (VLB) under the meltdown and refining periods of the process. In order to investigate the influence of additions of raw materials on energy, melt composition and slag properties, a static mass and energy balance model is developed. The distribution ratios for metallic elements and dust parameters are calibrated by using process data from an EAF. The model is then applied to investigate the effect of hot briquetted iron (HBI) additions in that particular EAF. The results showed that these additions resulted in an increased electricity consumption and slag amount. The model is then applied to predict how it is possible to adjust the amount of slag formers to reach a desired MgO saturation level. In addition, a statistical model is developed which simulate the melt composition by applying uncertainties in scrap composition, scrap weighing and element distribution factors. The model can estimate the mean and standard deviations in the element concentration of scraps. The results of the model application in an EAF showed that the simulated melt chemical composition is in good agreement with the measured one, when the estimated values for scraps are applied as data in the model.

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  • Public defence: 2020-06-09 15:15 Polhemsalen, Uppsala
    Jonsson, Helena
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Algebra and Geometry.
    Cells and 2-representations of bimodules over Nakayama algebras2020Licentiate thesis, comprehensive summary (Other academic)
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  • Wang, Xi
    et al.
    Umea Univ, Umea Plant Sci Ctr, Dept Ecol & Environm Sci, Umea, Sweden.;Swedish Univ Agr Sci, Linnean Ctr Plant Biol, Dept Plant Biol, Uppsala, Sweden..
    Bernhardsson, Carolina
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Human Evolution. Umea Univ, Umea Plant Sci Ctr, Dept Ecol & Environm Sci, Umea, Sweden.;Swedish Univ Agr Sci, Linnean Ctr Plant Biol, Dept Plant Biol, Uppsala, Sweden..
    Ingvarsson, Pär K.
    Swedish Univ Agr Sci, Linnean Ctr Plant Biol, Dept Plant Biol, Uppsala, Sweden..
    Demography and Natural Selection Have Shaped Genetic Variation in the Widely Distributed Conifer Norway Spruce (Picea abies)2020In: Genome Biology and Evolution, ISSN 1759-6653, E-ISSN 1759-6653, Vol. 12, no 2, p. 3803-3817Article in journal (Refereed)
    Abstract [en]

    Under the neutral theory, species with larger effective population size are expected to harbor higher genetic diversity. However, across a wide variety of organisms, the range of genetic diversity is orders of magnitude more narrow than the range of effective population size. This observation has become known as Lewontin's paradox and although aspects of this phenomenon have been extensively studied, the underlying causes for the paradox remain unclear. Norway spruce (Picea abies) is a widely distributed conifer species across the northern hemisphere, and it consequently plays a major role in European forestry. Here, we use whole-genome resequencing data from 35 individuals to perform population genomic analyses in P. abies in an effort to understand what drives genome-wide patterns of variation in this species. Despite having a very wide geographic distribution and an corresponding enormous current population size, our analyses find that genetic diversity of P. abies is low across a number of populations (pi = 0.0049 in Central-Europe, pi = 0.0063 in Sweden-Norway, pi = 0.0063 in Finland). To assess the reasons for the low levels of genetic diversity, we infer the demographic history of the species and find that it is characterized by several reoccurring bottlenecks with concomitant decreases in effective population size can, at least partly, provide an explanation for low polymorphism we observe in P. abies. Further analyses suggest that recurrent natural selection, both purifying and positive selection, can also contribute to the loss of genetic diversity in Norway spruce by reducing genetic diversity at linked sites. Finally, the overall low mutation rates seen in conifers can also help explain the low genetic diversity maintained in Norway spruce.

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  • Nøhr, Christian
    et al.
    Faxvaag, Arild
    Tsai, Chen Hsi
    Harðardóttir, Guðrún Auður
    Hyppönen, Hannele
    Andreassen, Hege Kristin
    Gilstad, Heidi
    Jónsson, Héðinn
    Reponen, Jarmo
    Kaipio, Johanna
    Øvlisen, Maja Voigt
    Kangas, Maarit
    Bertelsen, Pernille
    Koch, Sabine
    Villumsen, Sidsel
    Schmidt, Thomas
    Vehko, Tuulikki
    Vimarlund, Vivian
    Nordic eHealth Benchmarking2020Book (Other academic)
    Abstract [en]

    Read the Nordic report on eHealth benchmarking in the Nordic countries. With a hands-on approach the prerequisites for dealing with digitalisation is analysed with the aim of comparison across the countries.

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  • Tideman, Magnus
    et al.
    Halmstad högskola.
    Lövgren, Veronica
    Umeå University, Faculty of Social Sciences, Department of Social Work.
    Malmqvist, Johan
    Jönköpings universitet; Linnéuniversitetet.
    Övergången från ung till vuxen för personer med funktionsnedsättning: en kartläggning av det vetenskapliga kunskapsläget2020Report (Other academic)
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  • Gasanova, Oleksandra
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics, Algebra and Geometry.
    Properties of powers of monomial ideals2019Licentiate thesis, comprehensive summary (Other academic)
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  • Solander, Daniel D.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law.
    Dissertatio juridica inauguralis de possessione immemoriali, quam, ... sub præsidio viri consultissimi, dn. Danielis Solandri, ... pro gradu doctoris, eruditorum censuræ defert Carolus Krook, gubern. gener. Finlandiæ secretarius. In aud. Carol. maj. ad diem Junii a. MDCCLII. horis ante et post merid. consvetis.1752Dissertation (older thesis) (Other academic)
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  • Solander, Daniel D.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law.
    De crimine violati juramenti regii, Edsöres brott, pars prior, quam, ... moderatore, ... domino Daniele Solandro, ... dissertatione inaugurali, die XVI. Junii A. MDCCLII. In Aud. Carol. Maj. horis ante et post meridiem consvetis, pro gradu doct. in utroque jure obtinendo, publico erudit. exam. committit Carolus Magnus Siercken.1752Dissertation (older thesis) (Other academic)
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  • Solander, Daniel D.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law.
    Theses juridicæ de mutuo, quas, ... præside, ... Dn. Daniele Solandro, ... candido bonorum examini modeste submittit Tobias Ödbohm, Ostro-Gothus, in auditorio Carolino Majori die XXI. Aprilis, A. MDCCLII. H. A. M. S.1752Dissertation (older thesis) (Other academic)
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  • Solander, Daniel D.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law.
    Dissertatio juridica de tutela, pars posterior. Quam ... præside ... Daniele Solandro, ... publicæ ventilationti submittit stipendiarius Björnsonianus Olavus Wibelius, Sudermannus. In Auditorio Gustaviano die XXVIII. Junii Anni MDCCLXXVI., p. 21776Dissertation (older thesis) (Other academic)
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  • Solander, Daniel D.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law.
    Dissertatio juridica, de tutela, cujus partem priorem, ... præside ... Dn. Daniele Solandro, ... publicæ ventilationti submittit stipendiarius Nesselianus, Carolus Johann. Norell, Fierdhundrensis, in Auditorio Carolino Majori, ad diem XX Decemr. A. MDCCLI. H. A. M. S., p. 11751Dissertation (older thesis) (Other academic)
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  • Solander, Daniel D.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law.
    Dissertatio juridica, de pluralitate ac paritate votorum, quam, ... præside, ... Dn. Daniele Solandro, ... publico examini modeste submittit Martinus Ekman, Sudermannus. In Auditorio Gustaviano, d. VIII Novemb. anno MDCCXLVI. H. A. M. S.1746Dissertation (older thesis) (Other academic)
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  • Solander, Daniel D.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law.
    Dissertatio juridica de jure limitum, quam, ... præside ... Dn. Daniele Solandro, ... publico bonorum examini modeste submittit Paulus Timm, Joh. F. Westmannus. In Auditorio Carolino Majori die XXI mens. Junii anno MDCCXLVI. Horis, ante merediem (sic), solitis.1746Dissertation (older thesis) (Other academic)
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  • Solander, Daniel D.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law.
    Sebastiani Miegii, Argentoratensis, Tractatus de gradibus propinquitatis /1746Dissertation (older thesis) (Other academic)
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  • Solander, Daniel D.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law.
    Dissertationis juridicæ de præscriptione pars prior, quam, ... sub præsidio ... dn. Danielis Solandri, ... ad publicum eruditorum examen modeste defert stipendiarius regius, Carolus Krook B. f. Nylandus, in audit. Carol. maj. ad d. XIII. Dec. anni MDCCXLV. horis ante meridiem solitis.1745Dissertation (older thesis) (Other academic)
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  • Solander, Daniel D.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law.
    Dissertationis juridicæ de successione ab intestato pars prior, quam ... sub præsidio ... Dn. Danielis Solandri, ... ad publicm eruditorum examen modeste deffert stipendiarius regius, Petrus Vaselius, Westmannus. In Audit. Car. Maj. ad diem XXVIII. Nov. anni MDCCXLIV. Horis, ante meridiem, solitis.1744Dissertation (older thesis) (Other academic)
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  • Solander, Daniel D.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law.
    Dissertationis juridicæ, de interpretatione legum civilium, partem secundam, ... præside ... Dn. Daniele Solandro, ... publico examini modeste subjicit Ingemund Liliestråle, Sudermannus, in Audit. Gust. Maj. d. XI. Decemb. MDCCLXXXII. horis ante meridiem solitis., p. 21744Dissertation (older thesis) (Other academic)
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  • Solander, Daniel D.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Law.
    Dissertationis juridicæ de interpretatione legum civilium, partem primam, ... præside ... Dn. Daniele Solandro, ... publico examini modeste subjicit Joachim. Wilh. Bröms, Ingemundi Fil. Sudermannus. In Auditorio Carolino Majori horis a. m. solitis diei XIX. Maji anni MDCCXLIV., p. 11744Dissertation (older thesis) (Other academic)
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  • Solander, Daniel D.
    Uppsala University.
    Dissertatio juridica de probatione, speciatim duorum testium, in actione curiali. Quam jussu & auctoritate senatus acad. Vpsal. auctor, Daniel D. Solander et respondens, Carolus Fridericus Möller, Stockholmiensis, publico bonorum examini modeste submittunt. In audit. Carol. major. d. XX. Decembr. anno MDCCXXXIX. Horis ante meridiem solitis.1739Dissertation (older thesis) (Other academic)
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  • Sodenstierna, Eric Arvid
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Dissertatio de ingenio Æschinis oratoris quam venia incliti ord. phil. Ups. publice examinandam proponunt mag. Ericus Arv. Sodenstjerna ... et Isr. Bergman medelpado jemtlandus in audit. ecclesiast. die XIV. maji MDCCCXIV.1814Dissertation (older thesis) (Other academic)
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  • Liu, Ju
    et al.
    Malmo Univ, Dept Urban Studies, SE-20506 Malmo, Sweden..
    Bengtsson, Bo
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Institute for Housing and Urban Research. Malmo Univ, Dept Urban Studies, SE-20506 Malmo, Sweden.
    Bohman, Helena
    Malmo Univ, Dept Urban Studies, SE-20506 Malmo, Sweden..
    Pauli, Karin Staffansson
    Malmo Univ, Dept Urban Studies, SE-20506 Malmo, Sweden..
    A System Model and An Innovation Approach toward Sustainable Housing Renovation2020In: Sustainability, ISSN 2071-1050, E-ISSN 2071-1050, Vol. 12, no 3, article id 1130Article in journal (Refereed)
    Abstract [en]

    Housing renovation is a common concern to owners, tenants and to society at large. In addition to the high economic costs, the implementation of housing renovation usually have a long-term impact on the society and the built environment. This is a theoretical paper that develops a system model for understanding sustainable housing renovation as a system phenomenon which has multiple sustainability goals, complicated dynamic processes, diverse actors, and a sophisticated institutional environment. It identifies the key challenges of a sustainable housing renovation system, namely the conflicting sustainability goals and the conflicting stakeholder interests. To address these two challenges, the paper suggests an innovation approach in which the process of innovation (linear versus organic) and the typology of innovation (product versus process and business versus social) toward sustainable housing renovation are discussed.

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  • Fromell, Karin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Adler, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Åman, Amanda
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Manivel, Vivek Anand
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Huang, Shan
    Univ Gothenburg, Dept Med Biochem & Cell Biol, Inst Biomed, Sahlgrenska Acad, Gothenburg, Sweden..
    Dührkop, Claudia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Sandholm, Kerstin
    Linnaeus Univ, Linnaeus Ctr Biomat Chem, Kalmar, Sweden..
    Nilsson Ekdahl, Kristina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. Linnaeus Univ, Linnaeus Ctr Biomat Chem, Kalmar, Sweden..
    Nilsson, Bo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Assessment of the Role of C3(H2O) in the Alternative Pathway2020In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 11, article id 530Article in journal (Refereed)
    Abstract [en]

    In this study we investigate the hydrolysis of C3 to C3(H2O) and its ability to initiate activation via the alternative pathway (AP) of the complement system. The internal thioester bond within C3 is hydrolyzed by water in plasma because of its inherent lability. This results in the formation of non-proteolytically activated C3(H2O) which is believed have C3b-like properties and be able to form an active initial fluid phase C3 convertase together with Factor B (FB). The generation of C3(H2O) occurs at a low but constant rate in blood, but the formation can be greatly accelerated by the interaction with various surfaces or nucleophilic and chaotropic agents. In order to more specifically elucidate the relevance of the C3(H2O) for AP activation, formation was induced in solution by repeated freeze/thawing, methylamine or KCSN treatment and named C3(x) where the x can be any of the reactive nucleophilic or chaotropic agents. Isolation and characterization of C3(x) showed that it exists in several forms with varying attributes, where some have more C3b-like properties and can be cleaved by Factor I in the presence of Factor H. However, in common for all these variants is that they are less active partners in initial formation of the AP convertase compared with the corresponding activity of C3b. These observations support the idea that formation of C3(x) in the fluid phase is not a strong initiator of the AP. It is rather likely that the AP mainly acts as an amplification mechanism of complement activation that is triggered by deposition of target-bound C3b molecules generated by other means.

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  • Stalenus, Johannes Laurentii
    Uppsala University.
    Disputatio physica de elementis in genere, quam ... sub præsidio ... M. Johannis L. Staleni ... placidæ disquisitioni publicè submittit Laurentius Uddonis Robergius, Smolandus. In auditorio Gustaviano ad diem 3. Decembris horis à septima antemeridianis.1636Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Disputatio philosophica inauguralis theoremata miscellanea physica exhibens, quam ... sub præsidio M. Johannis L. Staleni ... pro magisterij philosophici insignibus & privilegijs consequendis, publicè ac placidè eventilandam & discutiendam exhibet. Thomas Iacobi Rozelius. In acroaterio Gustaviano ad diem 10. Septembris Anni M. DC. XXXVI. horis antemeridianis consuetis. ... .1636Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Disputatio inauguralis physico astronomica de coelo quam ... sub præsidio M. Johannis L. Staleni ... publicè examinandam proponit. Daniel D. Dalinus Lincopensis. In auditorio majori ad diem 18. Junij M DC XXXVI.1636Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Disputatio psychologica de anima sentiente, quam ... sub præsidio M. Johannis L. Staleni ... unicè liberalis exercitij ergò, placidæ ventilationi, publicè submittit Magnus Siggonis Aurelius smolandus. Ad diem 22. Junij 1636. horis à 7 antepomeridianis in auditorio Gustaviano. ...1636Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University.
    [Tetras] theorematum philosophicorum quam ... sub præsidio M. Johannis L. Staleni ... publicæ censuræ, ac æstimationi subijcit, Magnus Joan. Hofmannus de - petra - wexionensis. Ad diem 14. Maij, horis consvetis.1636Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University.
    Disputatio ethica, de summo bono civili, quam ... sub directione M. Johannis L. Staleni ... unicè exercendi ingenij ergò publicæ disquisitioni, & placidæ sententiarum collationi submittit, Magnus Svenonis Wennærus o-gothus. In auditorio Gustaviano ad diem 14. Maij, horis à 7 matutinis.1636Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University.
    Disputatio physica, de anima in genere, quam ... sub praesidio M. Johannis L. Staleni ... liberalis exercitij causâ, publicè ventilandam & discutiendam proponit. Petrus Olai Widbyensis, nericius. In auditorio Gustaviano ad ult. diem Aprilis horis à septima antemeridianis.1636Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Disquisitio inauguralis philosophica de forma substantiali. Quam ... sub praesidio M. Johannis L. Staleni ... pro magisterio in philosophiâ consequendo, ejusdemque privilegijs & immunitatibus gaudendis, publicæ censuræ submittit. Iosua Laurentii Gravius Nericiensis. Ad diem 14 Novemb. anni 1635 In auditorio Gustaviano, horis consuetis, á 7. ante-meridianis.1635Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University.
    Disquisitio philosophica de philosophia in genere. Quam ... praesidente M. Johanne L. Staleno ... publicæ disceptationi subijcit, Zacharias L. Humerus smol. In auditorio Gustaviano 11. Novemb. horis pomeridianis.1635Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Disputatio psychologica. De sensibus internis quam prosperante ac dirigente Jehovah ... sub praesidio M. Johannis L. Staleni Graeci idiomatis Profess: ... Pro laureâ, coronâ et privilegijs Philosophicis consequendis publicè examinandam exhibet et offert, Ericus Joh. Schrod[erus] Ubs. S. R. M. Stip. ac Medic. Studiosus. In collegio Veteri ad diem 17. Octobris Anno Christi 1635. tempore et horis consuetis1635Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Disputatio philosophica de natura, quam ... sub præsidio ... D. M. Johannis L. Staleni ... pro gradu magisterij philosophici ejusque insignibus & privilegijs reportandis, publicæ censuræ subijcit Johannes Jonæ Campanius Holmiensis. In auditorio Gustaviano ad diem 26. Septemb. horis à 7 ante meridianis & consuetis.1635Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Philosophy.
    Disputatio physica de meteoris in genere. Quam ... sub praesidio M. Johannis L. Staleni ... pro gradu philosophico ejusque privilegijs consequendis publico examini subijcit. Ericus N. Biugg / Gothus ad diem 2[6] Septemb. anni M. DC. XXV. in auditorio Gustaviano, horis matutinis consuetis.1635Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University.
    Disputatio physica. De anima in genere quam ... praeside M. Johanne L. Staleno ... placidæ disquisitioni ingenij exercendi ergò submittit Nicolaus Svenonis Collinus smolandus. In auditorio Gustaviano ad diem [ ] Junij horis à 7septima matutinis.1635Dissertation (older thesis) (Other academic)
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  • Stalenus, Johannes Laurentii
    Uppsala University.
    Dissertatio philosophica, habituum acquisitorum naturam exhibens. Quam ... directore M. Johanne Laurentii Staleno ... publicæ censuræ ingenij exercendi ergò subijcit, Johannes Lau: Larbergius wermelandus. In auditorio Gustaviano, ad diem 6. Iunij, horis à 7. matutinis. ... .1635Dissertation (older thesis) (Other academic)
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  • Bozaykut, Perinur
    et al.
    Marmara Univ, Dept Biochem, Sch Med, TR-34854 Istanbul, Turkey.;Acibadem Mehmet Ali Aydinlar Univ, Dept Mol Biol & Genet, TR-34752 Istanbul, Turkey..
    Sozen, Erdi
    Marmara Univ, Dept Biochem, Sch Med, TR-34854 Istanbul, Turkey.;Marmara Univ, Genet & Metab Dis Res & Invest Ctr, TR-34854 Istanbul, Turkey..
    Kaga, Elif
    Marmara Univ, Dept Biochem, Sch Med, TR-34854 Istanbul, Turkey.;Univ Hlth Sci, Hlth Applicat & Res Ctr, Afyon, Turkey..
    Ece, Asli
    Marmara Univ, Dept Biochem, Sch Med, TR-34854 Istanbul, Turkey..
    Ozaltin, Esra
    Marmara Univ, Dept Biochem, Sch Med, TR-34854 Istanbul, Turkey..
    Bergquist, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry. Uppsala Univ, Dept Chem BMC, Analyt Chem, Uppsala, Sweden..
    Ozer, Nesrin Kartal
    Marmara Univ, Dept Biochem, Sch Med, TR-34854 Istanbul, Turkey.;Marmara Univ, Genet & Metab Dis Res & Invest Ctr, TR-34854 Istanbul, Turkey..
    Yilmaz, Betul Karademir
    Marmara Univ, Dept Biochem, Sch Med, TR-34854 Istanbul, Turkey.;Marmara Univ, Genet & Metab Dis Res & Invest Ctr, TR-34854 Istanbul, Turkey..
    HSP70 Inhibition Leads to the Activation of Proteasomal System under Mild Hyperthermia Conditions in Young and Senescent Fibroblasts2020In: Oxidative Medicine and Cellular Longevity, ISSN 1942-0900, E-ISSN 1942-0994, Vol. 2020, article id 9369524Article in journal (Refereed)
    Abstract [en]

    Aging has been characterized with the accumulation of oxidized proteins, as a consequence of progressive decline in proteostasis capacity. Among others, proteasomal system is an efficient protein turnover complex to avoid aggregation of oxidized proteins. Heat shock protein 70 (HSP70) is another critical player that is involved in some key processes including the correct folding of misfolded proteins and targeting aggregated proteins to the proteasome for rapid degradation. The aim of this study was to determine the role of proteasomal system and heat shock proteins to maintain proteome balance during replicative senescence in mild hyperthermia conditions. Our results demonstrated that HSP40/70 machinery is induced by mild hyperthermia conditions independent from senescence conditions. Since HSP70 is largely responsible for the rapidly inducible cell protection following hyperthermia, the activation of "heat shock response" resulted in the elevation of HSP40/70 expressions as well as the proteasome activity. Interestingly, when HSP70 expression was inhibited, increased proteasomal activation was shown to be responsive to mild hyperthermia. Since HSP70 is involved in various stress-related pathways such as oxidative and endoplasmic reticulum stress, depletion of HSP70 expression may induce proteasomal degradation to maintain proteome balance of the cell. Thus, our data suggests that in mild heat stress conditions, molecular chaperone HSP70 plays an important role to avoid protein oxidation and aggregation; however, activities of proteasomal system are induced when HSP70 expression is depleted.

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  • Löfgren, Håkan
    et al.
    Linköpings universitet.
    Manni, Annika
    Umeå University, Faculty of Social Sciences, Department of applied educational science.
    Valuable everyday encounters in early childhood education: narratives from professionals2020In: Early years, ISSN 0957-5146, E-ISSN 1472-4421Article in journal (Refereed)
    Abstract [en]

    This article presents professionals’ narratives about valuableencounters with young children in early childhood education(ECE) settings. The study aims to provide an in-depth perspectiveon how professionals talk about ethics in practice, and the valuesaddressed in the narratives. Initially, professionals in Swedish ECEsettings defined their understanding of a valuable encounter witha child and then used a digital app to self-register 10 such encountersduring one day. After the self-registration, we interviewed theprofessionals and they told us about the encounters they hadexperienced. We identified three themes concerning who was thefocus of the encounters: the professional, the child, or both reciprocally.By using a narrative approach and Nussbaum’s ethicaltheoretical perspective, we show how different rationales wereinterwoven in the stories and that situated emotions were enactedand reflected. Finally, we noticed that many valuable encounterstook place in ‘in-between spaces’. They were not planned for ororganised, but occurred spontaneously through professionals’ sensitiveemployment of an ethics in practice.

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  • Reda, Waleed
    et al.
    KTH, School of Electrical Engineering and Computer Science (EECS), Computer Science, Communication Systems, CoS, Network Systems Laboratory (NS Lab).
    Bogdanov, Kirill
    KTH, School of Electrical Engineering and Computer Science (EECS), Computer Science, Communication Systems, CoS, Network Systems Laboratory (NS Lab).
    Milolidakis, Alexandros
    KTH, School of Electrical Engineering and Computer Science (EECS), Computer Science, Communication Systems, CoS, Network Systems Laboratory (NS Lab).
    Ghasemirahni, Hamid
    KTH, School of Electrical Engineering and Computer Science (EECS), Computer Science, Communication Systems, CoS, Network Systems Laboratory (NS Lab).
    Chiesa, Marco
    KTH, School of Electrical Engineering and Computer Science (EECS), Computer Science, Communication Systems, CoS, Network Systems Laboratory (NS Lab).
    Maguire Jr., Gerald Q.
    KTH, School of Electrical Engineering and Computer Science (EECS), Computer Science, Communication Systems, CoS.
    Kostic, Dejan
    KTH, School of Electrical Engineering and Computer Science (EECS), Computer Science, Communication Systems, CoS.
    Path Persistence in the Cloud: A Study of the Effects of Inter-Region Traffic Engineering in a Large Cloud Provider's Network2020In: Computer communication review, ISSN 0146-4833, E-ISSN 1943-5819, Vol. 50, no 2, p. 11-23Article in journal (Refereed)
    Abstract [en]

    A commonly held belief is that traffic engineering and routing changes are infrequent. However, based on our measurements over a number of years of traffic between data centers in one of the largest cloud provider's networks, we found that it is common for flows to change paths at ten-second intervals or even faster. These frequent path and, consequently, latency variations can negatively impact the performance of cloud applications, specifically, latency-sensitive and geo-distributed applications.

    Our recent measurements and analysis focused on observing path changes and latency variations between different Amazon aws regions. To this end, we devised a path change detector that we validated using both ad hoc experiments and feedback from cloud networking experts. The results provide three main insights: (1) Traffic Engineering (TE) frequently moves (TCP and UDP) flows among network paths of different latency, (2) Flows experience unfair performance, where a subset of flows between two machines can suffer large latency penalties (up to 32% at the 95th percentile) or excessive number of latency changes, and (3) Tenants may have incentives to selfishly move traffic to low latency classes (to boost the performance of their applications). We showcase this third insight with an example using rsync synchronization.

    To the best of our knowledge, this is the first paper to reveal the high frequency of TE activity within a large cloud provider's network. Based on these observations, we expect our paper to spur discussions and future research on how cloud providers and their tenants can ultimately reconcile their independent and possibly conflicting objectives. Our data is publicly available for reproducibility and further analysis at http://goo.gl/25BKte.

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  • Yamamoto-Hanada, Kiwako
    et al.
    Natl Ctr Child Hlth & Dev, Allergy Ctr, Tokyo 1578535, Japan..
    Borres, Magnus P
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Thermo Fisher Sci, Uppsala, Sweden..
    Åberg, Magnus K.
    Thermo Fisher Sci, Uppsala, Sweden..
    Yang, Limin
    Natl Ctr Child Hlth & Dev, Allergy Ctr, Tokyo 1578535, Japan..
    Fukuie, Tatsuki
    Natl Ctr Child Hlth & Dev, Allergy Ctr, Tokyo 1578535, Japan..
    Narita, Masami
    Natl Ctr Child Hlth & Dev, Allergy Ctr, Tokyo 1578535, Japan..
    Saito, Hirohisa
    Natl Res Inst Child Hlth & Dev, Dept Allergy & Immunol, Tokyo, Japan..
    Ohya, Yukihiro
    Natl Ctr Child Hlth & Dev, Allergy Ctr, Tokyo 1578535, Japan..
    IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo2020In: World Allergy Organization Journal, ISSN 1731-3317, E-ISSN 1939-4551, Vol. 13, no 2, article id 100105Article in journal (Refereed)
    Abstract [en]

    Background: Response patterns to allergen components among Japanese children have not been studied extensively. Objective: Our aim was to examine the differences in sensitization patterns at ages 5 years and 9 years to identify longitudinal changes in the degree and patterns of sensitization in a birth cohort of Japanese children. Methods: Our study enrolled 984 children at aged 5 years between 2008 and 2010, and 729 children aged 9 years between 2012 and 2014. Allergic diseases were assessed using the ISAAC and UK Working Party's Diagnostic Criteria. Serum-specific IgE titers to allergen components were measured by multiplex array ImmunoCAP ISAC when the children were aged 5 and 9 years. Principal component analysis (PCA) was performed to characterize IgE sensitization to allergen components. Results: The prevalence of allergic rhinitis increased considerably over time (10.6%-31.2%). Furthermore, the sensitization prevalence to allergen-specific IgE (sIgE) also increased from 57.8% at age 5 years to 74.8% at age 9 years. IgE sensitization prevalence to Der f 1 (mites) was 42.1% at age 5 years and 54.3% at age 9 years. Furthermore, children were highly sensitized to Cry j 1 (Japanese cedar) (32.8% at age 5 years and 57.8% at age 9 years). Principle component analysis showed that sensitization to PR-10 cross-reactive components was independent of sensitization to mite and that no children acquired sensitization to pollen before acquiring sensitization to mite. Conclusions: The prevalence of allergic rhinitis and related allergen components increased from age 5 years to age 9 years in Japanese children.

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  • Cedervall, Ylva
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Stenberg, Anna M.
    Falun Cent Hosp, Dept Geriatr & Rehabil Med, S-SE-70182 Falun, Sweden..
    Åhman, Hanna Bozkurt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Giedraitis, Vilmantas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Tinmark, Fredrik
    Swedish Sch Sports & Hlth Sci, SE-11433 Stockholm, Sweden.;Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, SE-75007 Uppsala, Sweden..
    Berglund, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Halvorsen, Kjartan
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control. Tecnol Monterrey, Dept Mechatron, Campus Estado Mexico, Monterrey 64849, NL, Mexico..
    Ingelsson, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Rosendahl, Erik
    Umea Univ, Physiotherapy, Dept Community Med & Rehabil, SE-90187 Umea, Sweden..
    Åberg, Anna Cristina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics. Dalarna Univ, Sch Educ Hlth & Social Studies, SE-79188 Falun, Sweden..
    Timed Up-and-Go Dual-Task Testing in the Assessment of Cognitive Function: A Mixed Methods Observational Study for Development of the UDDGait Protocol2020In: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 17, no 5, article id 1715Article in journal (Refereed)
    Abstract [en]

    New methods to screen for and identify early-stage dementia disorders are highly sought after. The purpose of this pilot study is to develop a study protocol for a dual-task test aimed at aiding the early detection of dementia disorders. We used the Timed Up-and-Go (TUG) test, which is a mobility task involving starting in a sitting position, standing up, walking three meters to cross a line on the floor, turning around, walking back and sitting down again. We combined TUG with the verbal task of naming different animals. Pilot study participants were 43 individuals with and without established dementia diagnoses who attended a clinic for memory assessment. Video-recorded test performances were systematically analysed. Deviant test performances concerning the interplay between test administration and participants' responses to the assessment instructions were revealed and led to refinements being made to the final study protocol. Exploration of the dual-task test outcome measures in a sub-sample of 22 persons, ten with and twelve without dementia, indicated that step-length and number of named animals after the turning point of the dual-task test might constitute appropriate measures for examining this kind of sample. We concluded that the refined study protocol is feasible for testing individuals undergoing initial memory assessments and healthy controls. Follow-up studies with larger samples are being carried out and will bring new knowledge to this area of research. It may also provide an opportunity for further studies exploring possibilities for broad clinical implementation.

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  • Blöndal, Viiu
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research. Department of Medical Sciences, Lung Allergy and Sleep Research, Uppsala University Hospital, Uppsala, Sweden. .
    Sundbom, Fredrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Borres, Magnus P
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation, Metabolism and Child Health Research. Thermo Fischer Sci, Uppsala, Sweden.
    Högman, Marieann
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Alving, Kjell
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation, Metabolism and Child Health Research.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Study of atopic multimorbidity in subjects with rhinitis using multiplex allergen component analysis2020In: Clinical and Translational Allergy, ISSN 2045-7022, E-ISSN 2045-7022, Vol. 10, no 1, article id 6Article in journal (Refereed)
    Abstract [en]

    Background Rhinitis is a common problem within the population. Many subjects with rhinitis also have atopic multimorbidity, such as asthma and eczema. The purpose of this investigation was to compare subjects with only rhinitis to those that have rhinitis, asthma and/or eczema in relation to immunoglobulin E (IgE) sensitization, inflammatory markers, family history, lung function and body mass index (BMI). Methods A total of 216 adult subjects with rhinitis from the European Community Respiratory Health Survey II were investigated with multiplex component allergen analysis (103 allergen components), total IgE, C-reactive protein, eosinophilic cationic protein, fractional exhaled nitric oxide and spirometry. Rhinitis, eczema, asthma and parental allergy were questionnaire-assessed. Results Of the 216 participants with rhinitis, 89 also had asthma and/or eczema. Participants with rhinitis that also had asthma or eczema were more likely to be IgE-sensitized (3.44, odds ratio, OR: 95% CI 1.62-7.30, adjusted for sex, age, mother's allergy, total IgE and forced expiratory volume (FEV1)). The number of IgE-positive components was independently associated with atopic multimorbidity (1.11, OR: 95% Cl 1.01-1.21) adjusted for sex, age, mother's allergy, total IgE and FEV1. When analysing different types of sensitization, the strongest association with atopic multimorbidity was found in participants that were IgE-sensitized both to perennial and seasonal allergens (4.50, OR: 95% CI 1.61-12.5). Maternal allergy (2.75, OR: 95% CI 1.15-4.46), high total IgE (2.38, OR: 95% CI 1.21-4.67) and lower FEV1 (0.73, OR: 95% CI 0.58-0.93) were also independently associated with atopic multimorbidity, while no association was found with any of the other inflammatory markers. Conclusion IgE polysensitization, to perennial and seasonal allergens, and levels of total IgE seem to be the main determinants of atopic multimorbidity in subjects with rhinitis. This indicates that disease-modifying treatment that targets IgE sensitization may be of value when decreasing the risk of developing atopic multimorbidity.

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  • Wunsch, Urban J.
    et al.
    Chalmers Univ Technol, Water Environm Technol, Architecture & Civil Engn, Sven Hultins Gata 6, S-41296 Gothenburg, Sweden.;Sven Hultins Gata 6, S-41296 Gothenburg, Sweden..
    Hawkes, Jeffrey A.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry.
    Mathematical chromatography deciphers the molecular fingerprints of dissolved organic matter2020In: The Analyst, ISSN 0003-2654, E-ISSN 1364-5528, Vol. 145, no 5, p. 1789-1800Article in journal (Refereed)
    Abstract [en]

    High-resolution mass spectrometry (HRMS) elucidates the molecular composition of dissolved organic matter (DOM) through the unequivocal assignment of molecular formulas. When HRMS is used as a detector coupled to high performance liquid chromatography (HPLC), the molecular fingerprints of DOM are further augmented. However, the identification of eluting compounds remains impossible when DOM chromatograms consist of unresolved humps. Here, we utilized the concept of mathematical chromatography to achieve information reduction and feature extraction. Parallel Factor Analysis (PARAFAC) was applied to a dataset describing the reverse-phase separation of DOM in headwater streams located in southeast Sweden. A dataset consisting of 1355 molecular formulas and 7178 mass spectra was reduced to five components that described 96.89% of the data. Each component summarized the distinct chromatographic elution of molecular formulas with different polarity. Component scores represented the abundance of the identified HPLC features in each sample. Using this chemometric approach allowed the identification of common patterns in HPLC-HRMS datasets by reducing thousands of mass spectra to only a few statistical components. Unlike in principal component analysis (PCA), components closely followed the analytical principles of HPLC-HRMS and therefore represented more realistic pools of DOM. This approach provides a wealth of new opportunities for unravelling the composition of complex mixtures in natural and engineered systems.

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  • Vitelaru, Catalin
    et al.
    Natl Inst Res & Dev Optoelect INOE 2000, 409 Atomistilor St,POB MG 05, Magurele 077125, Romania..
    Parau, Anca Constantina
    Natl Inst Res & Dev Optoelect INOE 2000, 409 Atomistilor St,POB MG 05, Magurele 077125, Romania..
    Constantin, Lidia Ruxandra
    Natl Inst Res & Dev Optoelect INOE 2000, 409 Atomistilor St,POB MG 05, Magurele 077125, Romania..
    Kiss, Adrian Emil
    Natl Inst Res & Dev Optoelect INOE 2000, 409 Atomistilor St,POB MG 05, Magurele 077125, Romania..
    Vladescu, Alina
    Natl Inst Res & Dev Optoelect INOE 2000, 409 Atomistilor St,POB MG 05, Magurele 077125, Romania.;Natl Res Tomsk Polytech Univ, Lenin Ave 43, Tomsk 634050, Russia..
    Sobetkii, Arcadie
    SC MGM STAR CONSTRUCT SRL, 7 Pancota St, Bucharest 022773, Romania..
    Kubart, Tomas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Electrical Engineering, Solid-State Electronics.
    A Strategy for Alleviating Micro Arcing during HiPIMS Deposition of DLC Coatings2020In: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 13, no 5, article id 1038Article in journal (Refereed)
    Abstract [en]

    In this work, we investigate the use of high power impulse magnetron sputtering (HiPIMS) for the deposition of micrometer thick diamond like carbon (DLC) coatings on Si and steel substrates. The adhesion on both types of substrates is ensured with a simple Ti interlayer, while the energy of impinging ions is adjusted by using RF (Radio Frequency) biasing on the substrate at -100 V DC self-bias. Addition of acetylene to the working Ar+Ne atmosphere is investigated as an alternative to Ar sputtering, to improve process stability and coatings quality. Peak current is maintained constant, providing reliable comparison between different deposition conditions used in this study. The main advantages of adding acetylene to the Ar+Ne gas mixture are an increase of deposition rate by a factor of 2, when comparing to the Ar+Ne process. Moreover, a decrease of the number of surface defects, from similar to 40% surface defects coverage to similar to 1% is obtained, due to reduced arcing. The mechanical and tribological properties of the deposited DLC films remain comparable for all investigated gas compositions. Nanoindentation hardness of all coatings is in the range of 25 to 30 GPa, friction coefficient is between 0.05 and 0.1 and wear rate is in the range of 0.47 to 0.77 x 10(-6) mm(3) N(-1)m(-1).

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