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  • Fjelkner, Annika
    Högskolan Kristianstad, Fakulteten för ekonomi, Avdelningen för ekonomi. Högskolan Kristianstad, Fakulteten för ekonomi, Forskningsmiljön Governance, Regulation, Internationalization and Performance (GRIP).
    Högskolepedagogisk debatt: samarbetsinlärning och What makes foreign students happy?2018Samlingsverk (redaktörskap) (Övrigt vetenskapligt)
  • Brussee, Janneke M.
    et al.
    Leiden Univ, LACDR, Div Syst Biomed & Pharmacol, Leiden, Netherlands.
    Yu, Huixin
    Novartis, Basel, Switzerland;Leiden Univ, LACDR, Div Syst Biomed & Pharmacol, Leiden, Netherlands.
    Krekels, Elke H. J.
    Leiden Univ, LACDR, Div Syst Biomed & Pharmacol, Leiden, Netherlands.
    Palic, Semra
    Netherlands Canc Inst NKI, Amsterdam, Netherlands;Leiden Univ, LACDR, Div Syst Biomed & Pharmacol, Leiden, Netherlands.
    Brill, Margreke J.E.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Barrett, Jeffrey S.
    Sanofi, Translat Informat, Bridgewater, NJ USA;Childrens Hosp Philadelphia, Dept Pediat, Div Clin Pharmacol & Therapeut, Philadelphia, PA 19104 USA.
    Rostami-Hodjegan, Amin
    Univ Manchester, Ctr Appl Pharmacokinet Res, Manchester, Lancs, England;Simcyp Ltd, Sheffield, S Yorkshire, England.
    de Wildt, Saskia N.
    Erasmus MC Sophia Childrens Hosp, Dept Pediat Surg, Rotterdam, Netherlands;Radboud Univ Nijmegen, Dept Pharmacol & Toxicol, Med Ctr, Nijmegen, Netherlands;Erasmus MC Sophia Childrens Hosp, Intens Care, Rotterdam, Netherlands.
    Knibbe, Catherijne A. J.
    St Antonius Hosp, Dept Clin Pharm, Nieuwegein, Netherlands;Leiden Univ, LACDR, Div Syst Biomed & Pharmacol, Leiden, Netherlands.
    Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach2018Ingår i: Pharmaceutical research, ISSN 0724-8741, E-ISSN 1573-904X, Vol. 35, nr 9, artikel-id 182Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose Changes in drug absorption and first-pass metabolism have been reported throughout the pediatric age range. Our aim is to characterize both intestinal and hepatic CYP3A-mediated metabolism of midazolam in children in order to predict first-pass and systemic metabolism of CYP3A substrates. Methods Pharmacokinetic (PK) data of midazolam and 1-OH-midazolam from 264 post-operative children 1-18 years of age after oral administration were analyzed using a physiological population PK. modelling approach. In the model, consisting of physiological compartments representing the gastro-intestinal tract and liver,intrinsic intestinal and hepatic clearances were estimated to derive values for bioavailability and plasma clearance. Results The whole-organ intrinsic clearance in the gut wall and liver were found to increase with body weight, with a 105 (95% confidence interval (CI): 5-405) times lower intrinsic gut wall clearance than the intrinsic hepatic dearance (i.e. 5.08 L/h (relative standard error (RSE) 10%) versus 527 L/h (RSE 7%) for a 16 kg individual, respectively). When expressed per gram of organ, intrinsic clearance increases with increasing body weight in the gut wall, but decreases in the liver, indicating that CYP3A-mediated intrinsic clearance and local bioavailability in the gut wall and liver do not change with age in parallel. The resulting total bioavailability was found to be age-independent with a median of 20.8% in children (95%CI: 3.8-50.0%). Conclusion In conclusion, the intrinsic CYP3A-mediated gut wall clearance is substantially lower than the intrinsic hepatic CYP3A-mediated clearance in children from 1 to 18 years of age, and contributes less to the overall first-pass metabolism compared to adults.

  • Petkova, Irina
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten. Royal Holloway Univ London, England.
    Abbey-Lee, Robin
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Lovlie, Hanne
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
    Parasite infection and host personality: Glugea-infected three-spined sticklebacks are more social2018Ingår i: Behavioral Ecology and Sociobiology, ISSN 0340-5443, E-ISSN 1432-0762, Vol. 72, nr 11, artikel-id UNSP 173Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The existence of animal personality is now well-documented, although the causes and consequences of this phenomenon are still largely unclear. Parasite infection can have pervasive effects on hosts, including altering host behaviour, and may thus contribute to differences in host personality. We investigated the relationship between the three-spined stickleback and its common parasite Glugea anomala, with focus on differences in host personality. Naturally infected and uninfected individuals were assayed for the five personality traits activity, exploration, boldness, sociability, and aggression. If infected fish behaved differently from uninfected, to benefit this parasite with horizontal transmission, we predicted behaviour increasing interactions with other sticklebacks to increase. Infection status explained differences in host personality. Specifically, Glugea-infected individuals were more social than uninfected fish. This confirms a link between parasite infection and host behaviour, and a relationship which may improve the horizontal transmission of Glugea. However, future studies need to establish the consequences of this for the parasite, and the causality of the parasite-host personality relationship. Significance statement Parasite infection that alters host behaviour could be a possible avenue of research into the causes of animal personality. We studied the link between infection and personality using the three-spined stickleback and its parasite Glugea anomala. We predicted that infected individuals would be more prone to interact with other sticklebacks, since this would improve transmission of this parasite. The personality of uninfected and naturally infected fish was measured and we observed that Glugea-infected sticklebacks were more social. Our results confirm a link between parasitism and variation in host personality.

  • Lundström, Mats
    et al.
    Malmö högskola.
    Jakobsson, Anders
    Malmö högskola.
    Scientific trustworthiness - the considerations and perceptions of students2012Ingår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 6, nr 2, s. 98-116Artikel i tidskrift (Refereegranskat)
    Abstract [sv]

    I den här artikeln beskrivs och diskuteras en empirisk studie där gymnasieelever diskuterar olika förklaringsmodeller kring ämnesområdet kropp och hälsa. Syftet har varit att utvärdera och analysera elevernas användning av begreppen tillförlitlighet och trovärdighet i förhållande till såväl vetenskapliga som icke-vetenskapliga förklaringsmodeller. Vi har analyserat elevernas användning av olika epistemologiska resurser i argumentativa situationer. Analysen ledde fram till att eleverna använde fyra olika typer av epistemologiska resurser; relativistiska, normativa, auktoritativa och vetenskapliga. Resultaten visar att samma elev kan använda olika epistemologiska resurser vid olika tillfällen. Vi anser att vårt teoretiska ramverk som utgår från epistemologiska resurser kan bidra till att förstå hur individer använder olika förklaringsmodeller i olika sammanhang.

  • Skeie, Geir
    Stockholms universitet.
    Education between formation and knowledge - a discussion based on recent English and Nordic research in religious education2012Ingår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 6, nr 2, s. 80-97Artikel i tidskrift (Refereegranskat)
    Abstract [no]

    Artikkelen tar utgangspunkt i spenningen mellom kunnskap (knowledge) og danning (formation) og utvikler dette som religionsdidaktisk problematikk ved hjelp av impulser fra engelsk religionsdidaktikk som tale rom å lære om og å lære av religion i skolen. Michael Grimmitt, Andrew Wright og Robert Jackson diskuteres i forhold til hverandre og det påpekeshvordan de alle fører den religionsdidaktiske diskusjon i nær kontakt med bredere tankestrømmer i pedagogisk og filosofisk tenkning. Denne diskusjon føres videre inn i nordiskreligionsdidaktisk debatt via Bråtens komparative studie og ved hjelp av Berndt Gustavssons danningsteoretiske perspektiver. Her vektlegges samspillet mellom ulike dimensjoner i danningen og det demonstreres hvordan dette kan bidra til å fange inn nyere forskningsbidrag i religionsdidaktikken. Konklusjonen er at fagdidaktisk debatt og forskning tjener på å blisett i lys av mer allmenpedagogiske perspektiver og at den kan bidra til utdyping av denallmenpedagogiske debatt om skolens innhold og mål.

  • Delacour, Laurence
    Malmö högskola.
    Interpreting the curriculum - mathematics and didactic contracts in Swedish preschools2012Ingår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 6, nr 2, s. 64-79Artikel i tidskrift (Refereegranskat)
    Abstract [sv]

    Syftet med artikeln är att belysa hur en vidgad matematikdidaktik kan ta form på några svenska förskolor. För att analysera hur några förskollärare omformar, preciserar och konkretiserar de matematiska målen i förskolans läroplan, med fokus på didaktiska frågor rörande innehåll - vad är matematik för yngre barn? och form - hur kan matematik kommuniceras, placerar jag min studie inom ramen för ett läroplansdidaktiskt perspektiv. Matematikdidaktiskt influeras jag av situationsteori och didaktiskt kontrakt är ett huvudbegrepp i analysen. Termen didaktiskt kontrakt ses som en metafor för uppsättningen av implicita och explicita regler för social och matematisk interaktion i en barngrupp. Jag använder en vidgad definition av det didaktiska kontraktet för att belysa hur förväntningar på relationen mellan lärare, barn och matematik framträder i talet om och transformeringen av de matematiska målen, med fokus på de didaktiska frågorna vad och hur. Sammantaget samspelar huvudbegreppen transformation och matematikdidaktiska kontrakt i texten. Analysen är då inriktad på hur samhälleliga förväntningar som uttrycks i nationella matematiska mål transformeras och framträder i form av didaktiska kontrakt i några förskolepraktiker.

  • Dimenäs, Jörgen
    et al.
    Högskolan Dalarna, Akademin Utbildning, hälsa och samhälle, Naturvetenskap.
    Gustafsson, Tommy
    Chalmers; Göteborgs universitet.
    Ognissanti, Damiano
    Chalmers; Göteborgs universitet.
    Förberedelse för högskolestudier i matematik - ett stöd för fortsatta studier2018Konferensbidrag (Refereegranskat)
  • Disputation: 2018-11-09 13:00 Rudbecksalen, Uppsala
    Rosestedt, Maria
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Theranostics.
    Affibody Molecules for HER3-targeted Theranostics of Malignant Tumours2018Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    The HER3 receptor plays a strong role in disease progression and resistance to therapies in several cancer types. Due to its endogenous expression and low overexpression in malignant tumours, it is a particularly challenging target. The primary aim of this thesis project was to develop, evaluate and characterize affibody molecules for theranostic applications in HER3-expressing malignant tumours.

    Paper I investigated the in vivo targeting properties and therapeutic efficacy of a bivalent affibody construct fused with an albumin binding domain, ZHER3-ABD-ZHER3. This construct could slow down the growth of HER3-expressing tumour xenografts without causing health problems or side effects in mice.

    Paper II compared the in vitro and in vivo properties of two HER3-targeting affibody molecules (Z08698 and Z08699) to select an imaging probe for HER3 diagnostics. While the two constructs had similar properties, Z08698 demonstrated better blood clearance and better radioactivity retention in tumours.

    Paper III and IV present the development of a HER3 imaging probe for PET using gallium and cobalt isotopes. We demonstrated that imaging of HER3 expression could be obtained as soon as 3 h pi using gallium-68. Additionally, we demonstrated that affibody molecules labelled with a neutral cobalt-NOTA complex had a lower radioactivity uptake in the liver than molecules radiolabelled with a positive gallium-NOTA complex. Imaging contrast increased over time. As the dose of the injected protein increased, the activity uptake in normal organs decreased, whereas the tumour uptake remained the same, which improved the imaging contrast and allowed discrimination between xenografts with high and low HER3 expression. This modification did not influence tumour activity uptake.

    Paper V presents the HER3-targeting affibody molecule trimer as a tool to block hepatic uptake in order to increase the imaging contrast in the liver. The trimer demonstrated its ability to bind to endogenous receptors in the liver, which decreased the hepatic uptake of the radiolabelled monomer. This phenomenon enabled the monomer to pass the liver barrier, which increased tumour radioactivity uptake and improved imaging contrast.

  • Forsberg Ahlcrona, Mirella
    Högskolan i Skövde.
    "Spindlarna i Falköping" - en studie om hur dockan som medierande redskap bidrar till utveckling av förskolans kommunikativa miljö2012Ingår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 6, nr 2, s. 48-63Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This article illustrates different communicative contents based on children’s motivation and intention that through the puppet play speak and act linguistically. In the empirical section, the puppet consists and functions as a starting point for children’s interaction and narratives. The research interest is directed towards children’s ways of expressing the meaning of the puppet and motives that are generated in the interaction between the puppet and the children in their mutual play. The study result shows that children in interaction with the puppet broaden the linguistic environment in the preschool when they express their knowledge and experience belonging to other contexts than preschool.

  • Zhou, Yitian
    et al.
    Karolinska Inst, Dept Physiol & Pharmacol, Sect Pharmacogenet, Stockholm, Sweden.
    Mägi, Reedik
    Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
    Milani, Lili
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.
    Lauschke, Volker M.
    Karolinska Inst, Dept Physiol & Pharmacol, Sect Pharmacogenet, Stockholm, Sweden.
    Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk2018Ingår i: Journal of Lipid Research, ISSN 0022-2275, E-ISSN 1539-7262, Vol. 59, nr 10, s. 1987-2000Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Abnormal plasma apolipoprotein levels are consistently implicated in CVD risk. Although 30% to 60% of their interindividual variability is genetic, common genetic variants explain only 10% to 20% of these differences. Rare genetic variants may be major sources of the missing heritability, yet quantitative evaluations of their contribution to phenotypic variability are lacking. Here, we analyzed whole-genome and whole-exome sequencing data from 138,632 individuals across seven major human populations to present a systematic overview of genetic apolipoprotein variability. We provide population-specific frequencies of 38 clinically important apolipoprotein alleles and identify further 6,875 genetic variants, 33% of which are novel and 98.7% of which are rare with minor allele frequencies <1%. We predicted the functional impact of rare variants and found that their relative importance differed drastically between genes and among ethnicities. Importantly, we validated the clinical relevance of multiple variants with predicted effects by leveraging association data from the CARDIoGRAM (Coronary Artery Disease Genomewide Replication and Meta-analysis) and Global Lipids Genetics consortia. Overall, we provide a consolidated overview of population-specific apolipoprotein genetics as a valuable data resource for scientists and clinicians, estimate the importance of rare genetic variants for the missing heritability of apolipoprotein-associated disease traits, and pinpoint multiple novel apolipoprotein variants with putative population-specific impacts on serum lipid levels.

  • Davidsson, Eva
    Malmö högskola.
    Investigating visitors' learning related to science centre exhibits - a progress report of recent research literature and possible future research foci2012Ingår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 6, nr 2, s. 28-47Artikel i tidskrift (Refereegranskat)
    Abstract [sv]

    Forskningsfältet som rör lärande i informella miljöer växter ständigt och under den senaste tiden har antalet artiklar som fokuserar lärande i relation till ett besök på ett science center eller museum ökat kraftigt. Men vilka slutsatser kan man dra när det gäller utställningar och besökares lärande? Vilka metodologiska trender kan man se och vilka framtida forskningsområden kan tänkas utgöra intressanta fält? Denna forskningsgenomgång analyserar och diskuterar olika forskningsstudier som fokuserar besökares lärande och deras interaktioner med utställningar samt studier som utvärderar utställningsmiljöer. Vidare diskuteras trender med avseende på olika metodologiska ansatser samt föreslår framtida forskningsfokus inom fältet.

  • Andersson, Erik
    Högskolan i Skövde; Örebro universitet.
    Rum och plats i didaktiken. Om var-frågan i svensk didaktisk forskning och undervisning - exemplet digitala medier2012Ingår i: Utbildning och Lärande / Education and Learning, ISSN 2001-4554, Vol. 6, nr 2, s. 16-27Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The purpose of the article is to argue for a systematic research approach on space and place, the WHERE-question in the Swedish research field of didactics. Two research traditions in subject and general didactics, focusing the WHAT- and the HOW-question, dominate the field. The educational situation of today is highly digitally driven which motivates the relevance of a more thorough and systematic analysis of the WHERE-question. It is argued that Swedish didactical research, and teaching in school in general, has to amplify the attention to the WHERE-question. Space and place are not empty containers in which social life happens to unfold. Space and place determines the communication, interaction and meaning making of individuals – individuals are always claimed by space and place.

  • Olson, Maria
    Högskolan i Skövde.
    Utbildning & Lärande 2012:2: Tema: Ett vidgat perspektiv på ämnesdidaktik2012Samlingsverk (redaktörskap) (Refereegranskat)
  • Hermelin, Brita
    et al.
    Linköpings universitet, Institutionen för studier av samhällsutveckling och kultur, Centrum för kommunstrategiska studier – CKS. Linköpings universitet, Filosofiska fakulteten.
    Gustafsson, Sara
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Industriell miljöteknik. Linköpings universitet, Tekniska fakulteten.
    Ostlänken och hållbar regional utveckling: förstudie med utgångspunkt i erfarenheter av höghastighetsjärnväg i EU2018Rapport (Övrigt vetenskapligt)
    Abstract [sv]

    Denna rapport presenterar resultaten från en förstudie och har sin upprinnelse i planering och organisering inför utbyggnaden av Ostlänken, som är en höghastighetsjärnväg (HHJ) med sträckning från Järna strax söder om Stockholm till Linköping. Titeln för förstudien har varit ”Ostlänken och regional utveckling – en kunskapsöversikt”. De rådande tidsplanerna enligt Trafikverkets hemsida (vid tiden för denna rapports färdigskrivande) anger att Ostlänken beräknas vara färdig mellan 2033 och 2035. Detta är den första etappen i planer för ytterligare framtida investeringar för HHJ i Sverige som knyter ihop de tre största städerna; Stockholm, Göteborg och Malmö.

    Rapporten redovisar en kunskapsöversikt vad gäller utbyggnad av HHJ med avseende på regionala e.ekter. Det bakomliggande motivet till att genomföra en sådan översikt är att den ska ligga till grund för att utforma framtida insatser för att den nya infrastrukturen ska stödja en hållbar regional utveckling. Ett särskilt intresse riktas mot hur strategisk planering och samverkansinsatser sker regionalt.

    Det studerade bakgrundsmaterialet berör Sverige och andra länder inom EU. För EU har utbyggnaden av HHJ genom programmet ”The Trans-European Transport Network (TEN-T) varit ett framskrivet projekt sedan en tid tillbaka. Sett till EU:s medlemsländer är utbyggnaden av HHJ ojämn. De största systemen finns i Spanien, Frankrike och Tyskland. De länder som tidigast byggde ut sina nät för höghastighetståg var Frankrike, Spanien, Tyskland, Italien, Belgien och Nederländerna (Trafikverket uå). Ingen av de nordiska länderna har ännu någon byggd HHJ. Det har dock skett viss annan utbyggnad av banor i Sverige sedan 1990-talet. Erfarenheter från utbyggnaden av Botniabanan visar att omfattade miljöe.ekter uppstår vid byggnation av nya tågbanor. Det påminner om att miljövinsterna som uppstår genom att det är mer hållbart med resande på tåg behöver balanseras med de miljökostnader som byggandet innebär.

    Med utgångspunkter i EU:s storskaliga och långsiktiga program för utbyggnad av HHJ och planeringen av den första etappen av HHJ i Sverige genom Ostlänken samt målsättningar om hållbar regional utveckling syftar denna rapport till att sammanställa en kunskapsöversikt som kan utgöra underlag för strategisk planering och samverkansinsatser som sker regionalt i anslutning till utbyggnad av HHJ.

    Denna kunskapsöversikt utvecklas i rapporten utifrån två övergripande teman:

    1. Policy och planering som sker i samband med investeringar och utbyggnad av HHJ.
    2. Erfarenheter som finns med avseende på e.ekter av HHJ på hållbar regional utveckling.

    De stora investeringarna som genomförts och planeras för att bygga HHJ reflekterar stora förhoppningar på att detta stödjer hållbar regional utveckling. En viktig lärdom från tidigare forskning är emellertid att regionala och lokala e.ekter av HHJ varierar och att detta behöver förstås i ett kontextuellt perspektiv. Generellt sett uppstår positiva e.ekter för de största städerna. Vad gäller e.ekter för andra nivåer i de nationella systemen av städer visar sammanställningen i den här rapporten på högst varierande utvecklingsvägar. Några underliggande faktorer som skapar ojämna e.ekter av HHJ har samband med strukturella villkor som tidigare framvuxen fysisk struktur, de regionala näringslivsstrukturerna samt den relativa geografiska positionen för olika städer. Forskningen visar även att strategisk planering och policy för HHJ-investeringarna har e.ekter på hur investeringar för HHJ påverkar hållbar regional utvecklingen (Henriksson och Summerton 2016).

    Rapportens slutsatser utgår från att strategisk planering för HHJ behöver ske i samverkan, att planering och byggnationer i relation till HHJ-utbyggnad sker utifrån förväntade e.ekter samt att tidsperspektivet behöver beaktas vad gäller hur infrastruktur för transporter kan nyttjas i ett längre framtidsperspektiv. I den avslutande resultatdiskussionen lyfts några fokusområden fram som angelägna med avseende på hur utbyggnad av HHJ kan nyttiggöras för hållbar regional utveckling.

    • Att utveckla och konsolidera regionala samverkansstrukturer som en resurs för ändamålsenlig regional planering och andra regionala insatser.
    • Att stödja kunskapsspridning och kännedom om förväntade skärpta krav på miljöhänsyn vid byggnation.
    • Att organisera för kompetensförsörjning för att förstärka möjligheter att sysselsättningstillväxten vid byggnationen kan påverka arbetsmarknaden strukturellt.
    • Att organisera för policyintegrering i samband med planeringen av bostadsbyggandet för att stödja en sammanhållen utveckling.
    • Att integrera organisering och planering för resor och kollektivtrafik i relation till HHJ för att uppnå hållbar regional utveckling sett till dess olika dimensioner.

    Avslutningsvis är det viktigt att påminna om att denna rapport är en förstudie och det har varit nödvändigt att avgränsa diskussionen inom det breda fält som utbyggnad av HHJ relaterar till. Temat är stort och genom att inkludera flera studier, fördjupningar och policydokument skulle diskussionen ytterligare kunnat fördjupas.

  • Dimenäs, Jörgen
    et al.
    Högskolan i Borås.
    Björklund, Margareth
    Högskolan Kristianstad.
    Häggkvist, Kristin
    Högskolan i Borås.
    Larsson, Ingamay
    Högskolan i Borås.
    Malm, Annika
    Högskolan i Borås.
    Rundgren, Monica
    Högskolan i Borås.
    Welin Mod, Agneta
    Högskolan i Borås.
    Retorikens beprövande erfarenhet ur yrkesverksamma lärar- och sjuksköterskehandledares perspektiv2016Ingår i: Utbildning och lärande, ISSN 1653-0594, Vol. 6, nr 1, s. 98-116Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This study aims to investigate the concept of proven experience, which is being increasingly used and emphasised in documents relating to the education of student teachers and nurses as well as in the training of these two professions. The study is aimed at academic vocational training (AVT) and is based upon interviews with the tutors of student teachers and nurses during their periods of AVT. The purpose of this study is to understand what constitutes the essence of proven experience, arising from the verbal statements given by AVT tutors in the field. The conclusion of this study is that the concept of proven experience should be considered at three levels: experience, tested experience and proven experience. Furthermore, those who use it without further consideration should understand the complexity of the concept. From a critical perspective it seems that government agencies use a concept that we assume is more characterised by ideological rhetoric than by conceptual preciseness.

  • Nordänger, Ulla Karin
    et al.
    Linnéuniversitetet.
    Lindqvist, Per
    Linnéuniversitetet.
    Att skärpa den praktiska blicken - handledares erfarenheter av försök att stärka kvalitet i VFU2012Ingår i: Utbildning och lärande, ISSN 1653-0594, Vol. 6, nr 1, s. 80-97Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The article describes supervisors’ experiences of attempting to improve quality in student teaching by focusing attention on their own expertise. We discuss if and how practical knowledge can be formulated and present the three methods – Delphi method, stimulated recall and dialogue seminars – used in a design experiment to develop the supervisors’ capability to, individually as well as collectively, identify and articulate such knowledge. The central question is if the ability to direct attention to the practical and tacit parts of teachers’ expertise increases the quality of the supervision and the assessment of the teacher student skills or not. The results indicate that the supervisors experience that their practical sight has been sharpened and that their standards have been raised.

  • Nilsson, Ingrid
    et al.
    Högskolan i Halmstad.
    Wictor, Ewa
    Högskolan i Halmstad.
    Att undersöka processhandledning av lärares handledning2012Ingår i: Utbildning och lärande, ISSN 1653-0594, Vol. 6, nr 1, s. 68-79Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The aim of the study is to study voluntary process supervising, with seven subject teachers during ten occasions at Higher Education. The study is inspired by models in Gjems (2007) and in Franke, Arvidsson and Gustafsson (2007), and the method of observation and analysis used is based on concepts from Wenger (2000) and Scollon and Scollon (2003). The results show that questions and discussions that are being actualized in the supervising practice vary between general and specific topics and between process and content. During the supervising activity the teachers mainly take their starting point in practice and less in science, but in the written examination the teachers link their experiences from practice to different theories and scientifically oriented concepts in the supervising activity.

  • Herrman, Margaretha
    Högskolan Väst.
    Utbildade för filmproduktion - hinder och möjligheter för etablering2012Ingår i: Utbildning och lärande, ISSN 1653-0594, Vol. 6, nr 1, s. 30-49Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Workers who desire employment inside film production come from a variety of experience levels. In Sweden, the opportunities to obtain work in the film production industry are limited and depend on situations and norms defined by the industry itself. The goal of this article is to identify challenges faced by a relatively unknown group of industry workers: those students representing industrial intellectuals who have received higher educational training in film production work, to identify the difficulties and opportunities they face in their transition from education to employment in the industry. This study is a qualitative one, based on interviews with four young adults who are recent graduates of an educational training program for film production work. The respondents were asked to identify levels of uncertainty and competitiveness prevailed and what opportunities and threats existing as important factors in terms of obtaining work. The findings demonstrate that students who are transitioning into careers are met by an environment with high demands for networking and expectation to adapt their performances and lifestyles to the demands of the job. An aptitude for work is often measured by how well workers adapt to the industry’s culture and values.

  • Emanuel, Martin (Redaktör)
    Gärdebo, Johan
    Filosofi och historia, KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Filosofi och teknikhistoria, Historiska studier av teknik, vetenskap och miljö.
    Saabs omborddatorer och TT&C för rymdverksamhet: Transkript av ett vittnesseminarium vid RUAG Space i Göteborg den 2 maj 20172018Rapport (Övrigt vetenskapligt)
    Abstract [en]

    The witness seminar “Saabs omborddatorer och TT&C för rymdverksamhet” (Saab’s on board computers and TT&C for space activities) was held at RUAG Space in Gothenburg on May 2, 2017, and was led by Lennart Lübeck, assisted by Mar-tin Emanuel. The seminar focused on how Saab’s (or, more correctly, until 1983, Saab-Scania’s, and from then on Saab Space’s) Gothenburg office embarked on European space-related projects, in particular relating to communication sys-tems, Telemetry, Tracking and Command (TT&C), as well as onboard computers (OBC) for spacecraft. After having failed to win bids on ESRO satellites in the 1960s, Saab joined the MESH consortium in 1967. In the seminar, MESH’s success-ful bid for OTS (Orbital Test Satellite) stands out as an im-portant turning point for the company’s future contracts with ESRO and later ESA. With respect to Saab’s development of onboard computers, it initially relied substantially on collabo-ration with the American company TRW. Building on the learning process from the ESRO-funded development pro-gram for an Engineering Model, Saab, and later RUAG Space, would deliver onboard computers for several genera-tions of the Ariane launching rockets, SPOT-satellites, and many more. Beginning with the Hipparcos satellite, TT&C and the onboard computer were merged into a data handling system. In the process, what had previously been two sepa-rate groups of the company merged into one. With respect to Saab’s motives to engage in space technology in the first place, the main motive appears to have been to maintain and promote the company’s technical expertise, more so than any hopes to be able to set up large-scale manufacturing. The seminar also treated the relationship between Saab’s two branches engaged in space-related activities. Although their organizational belonging shifted over the years, Linköping remained the location of management and formal interna-tional contacts—and also nationally-oriented projects—while the Gothenburg office was home to the projects for the in-ternational market. The OBC group in Gothenburg tried to maintain as much independence as possible vis-à-vis Linkö-ping, although it relied on upper management for negotiating and winning international contracts. Also important to secure European contracts for Saab was the support, at critical mo-ments, of the Swedish delegation to ESRO and ESA, as well as excellent Swedish contacts with CNES.

  • Gärdebo, Johan (Redaktör)
    Filosofi och historia, KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Filosofi och teknikhistoria, Historiska studier av teknik, vetenskap och miljö.
    Bildens behandling och utvecklingen av digital fjärranalys: Transkript av ett vittnesseminarium på Tekniska museet i Stockholm den 14 juni 20172018Rapport (Övrigt vetenskapligt)
    Abstract [en]

    This is a transcript from the witness seminar “Bildens behan-dling och utvecklingen av digital fjärranalys” (Processing the im-age and the development of digital remote sensing), held at the Swedish National Museum of Science and Technology in Stock-holm, June 14, 2017, and was led by Håkan Olsson and Johan Gärdebo. The seminar participants, who were all pioneers from the early Swedish development of digital remote sensing, de-scribed their role in various initiatives and activities for devel-opment of remote sensing related image processing from the 1970s until the late 1990s. During this period, several university groups, government agencies and companies located all over Sweden took interest in remote sensing. The Swedish Defence Research Institute (FOA) developed the first digital image analy-sis system, Piccola, in the early 1970s. Piccola, hosted as a main frame computer at Stockholm’s computer centre QZ, became a central resource for the early development of digital remote sensing in Sweden. During this early period, Professor Gunnar Hoppe at Stockholm University took a leading role for technol-ogy- and method development by chairing the National Remote Sensing Committee, providing a forum for various initiatives to meet, grant funding, and build momentum for concerted efforts. In the end of the 1970s, the Swedish Space Corporation (SSC) became the central force for development of the remote sensing infrastructure in Sweden. Piccola was replaced by a more mod-ern interactive image analysis system at SSC, the IAS system. This was part of SSC efforts to make satellite remote sensing operational. Additional parts in this effort included establish-ment of a satellite data receiving station at Esrange and later in the 1980s the establishment of the SSC’s subsidiary Satellitbild AB in Kiruna, which processed SPOT satellite data for the world market. SSC also developed the EBBA series of image analysis systems, attached to a PC, which were used by several Swedish research groups. From the late 1970s and onwards, there were a number of spin-off companies from FOA, most notably Con-text Vision and Teragon, that developed image processing hard-ware and software for uses also beyond that of geographical in-formation. These companies also sold systems to the Swedish Land Survey and SSC. Swedish organisations had a large pres-ence internationally, for example as part of development projects by consultancy firms, which also led to more operational uses of image processing. As computer capacity increased, in particular the introduction of colour graphics on standard computers, im-age processing development moved from special hardware to standard work stations and eventually personal computers and the applications that have become operational, for example in the forest sector, has been integrated with GIS applications in tailor made production-oriented systems.

  • Boschini, Anne
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutet för social forskning (SOFI).
    Dreber, Anna
    von Essen, Emma
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutet för social forskning (SOFI).
    Muren, Astri
    Ranehill, Eva
    Gender, risk preferences and willingness to compete in a random sample of the Swedish population2018Rapport (Övrigt vetenskapligt)
  • Herrman, Margaretha
    et al.
    Högskolan Väst.
    Nilsson, Lena
    Högskolan Väst.
    Att bygga gemensamma miljöer - delaktighet och lärande genom dialogplanering2012Ingår i: Utbildning och lärande, ISSN 1653-0594, Vol. 6, nr 1, s. 12-29Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The aim is to investigate how dialogue planning can provide users and professionals with tools for learning and be a path to organizational development in the context of design and construction of a town square and a sports hall adjacent to a K-9 school. Design and construction was carried out in collaboration between a municipality, a building contractor, school staff and students. A model for dialogue planning using artistic practice and collaboration with an artist was applied to develop an authentic dialogue. An architect and an artist were project managers. Their role was to support students to formulate interests, needs and creative solutions. Awareness of the complexity of planning was developed. Students’ participation had major impact on the design of the town square. With support, students can give a qualified contribution, significant for design of physical environment. Students’ involvement contributes to the learning of professional partners. Learning takes place primarily at the horizontal level around the students. Learning can be seen vertically among representatives of the school and community. Among building producers horizontal learning can be seen with entrepreneurs directly facing students.

  • Emanuel, Martin (Redaktör)
    IRF och den svenska rymdforskningen: Transkript av ett vittnesseminarium på Institutet förrymdfysik i Kiruna den 16 november 20172018Rapport (Övrigt vetenskapligt)
    Abstract [sv]

    The  witness  seminar  “IRF  och  den  svenska  rymdforskning-en” (IRF and Swedish space research) was held at IRF (Insti-tutet  för  rymdfysik,  The  Swedish  Institute  of  Space  Physics)  in  Kiruna  on November 16, 2017,  and  was  led  by  Martin Emanuel  and  Johan  Kärnfelt.  The  seminar  covered  three  themes: key events in the history of the institute; the funding structures  of  Swedish  space-related  research;  and  issues  con-cerning  instrumentation  of  space  physics  experiments.  Vari-ous key events were proposed, ranging from contingencies in the establishment of the institute in 1957 to the institute’s en-gagement  in  ESRO’s  very  first  scientific  satellites,  the  Swe-dish-Soviet research collaborations initiated in the 1970s, and the  Swedish  scientific  satellite  Viking  launched  in  1986.  The  1960s  was  a  difficult  decade  for  Swedish  space-related  re-search,  with  most  national  funding  channelled  through  the  European   Space   Research   Organisation   (ESRO).   Since   ESRO  prioritized  satellite  programmes,  the  institute—as  the  only  Swedish  group  with  experience  of  satellites—fared  well  compared  to  other  research  groups.  The  institute  came  to  dominate  Swedish  space  physics.  In  the  period  1970–1994, the  first  director  of  the  institute  also  chaired  the  scientific committee  of  the  Swedish  research  councils  (Forskningsrådens rymdnämnd)  until  1972,  and  then  of  the  Swedish  National  Space Board (Statens delegation för rymdverksamhet). The issue of potential bias and conflict of interest was discussed. Whereas some  panellists  stressed  the  fair,  smooth  and  non-conflicting nature of the situation, others argued that certain groups felt discriminated.   The   participants   often   mentioned   the   im-portance of having in-house engineering skills at the institute: it  was  cheaper,  made  possible  the  long-term  build-up  of  competence, and allowed for the immediate collaboration be-tween the scientists and the engineers in the design of exper-iments. In contrast, many other groups relied on the technical expertise  of  the  Swedish  Space  Corporation  (SSC; Rymdbo-laget). The relationship between the institute and SSC appears to  have  been  one  of  both  cooperation  and  competition.  Breakthroughs  in  microelectronics  in  particular  had  a  large  impact  on  the  instrumentation  of  scientific  experiments.  In-deed, Soviet interest in Western microelectronics was pointed out by several participants as an important motivation for the Soviets to partake in space research collaboration with the in-stitute; for the institute, the collaboration meant opportunities to launch experiments with Soviet rockets.

  • Gärdebo, Johan (Redaktör)
    Filosofi och historia, KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Filosofi och teknikhistoria, Historiska studier av teknik, vetenskap och miljö.
    Svenska bidrag till europeisk radarfjärranalys: Transkript av ett vittnesseminarium på Kungliga Tekniska högskolan i Stockholm den 13 november 20172018Rapport (Övrigt vetenskapligt)
    Abstract [sv]

    The    witness    seminar    “Svenska bidrag    till    europeisk radarfjärranalys”  (Swedish contributions  to European radar remote   sensing)   was   held   at   KTH   Royal   Institute   of    Technology  on  November  13, 2017,  and  was  led  by  Eva Cronström and Johan Gärdebo. The seminar focused on the development  of   radar  remote  sensing  from  the  1960s  until  the  early  2000s. While  the  US  had  developed  radar  satellites  since the 1960s, the international demonstrations did not take place until the launch of  Seasat in 1978. In Sweden, the major industries  Saab  and  Ericsson had  conducted  seminar-series on    space    technology    since the    1960s.    The    Swedish    government  agencies  have  over  the  years  provided  limited  funding,  primarily  through  the  Swedish  Board  for  Space  Activities, that served to catalyse subsequent initiatives from a number of  groups within academia and the industries. Apart from environmental problems there were several projects th at initially  had  been  funded  by  national  defence  organisations. The  mid-1970s  was  a  period  when  many  of   the  major  organisations  on  radar data began  collaborating.  The  most  prominent  developers  of   radar  remote  sensing  were  the  Swedish  National  Defence  Research  Institute  (FOA),  the  Swedish Space Corporation, Saab and Ericsson. The Swedish Coast    Guardand the    Swedish    Meteorological    and    Hydrological  Institute  were  the  main  users  of   radar data. Experiments  with  airborne  systems  provided  the  embryo  to  subsequent radar data  from  satellites.  While  the  US  Seasat  demonstrated uses   of  radar data,   it   also   made   visiblelimitations  for  European  influence  over  American  systems. The  European  Space  Agency  (ESA)  embarked  in  late  1970son developing its own radar data through the satellites ERS-1, and  -2,  and  later  Envisat.  Since  uses  for  satellite  radar datawere defined  as  experimental,  it  could  be  described  as  “a solution in search of  a problem”. During the 1980s and 1990s, the   Chalmers   University   of    Technology,   along   with   the   above-mentioned groups,  were  central  to  experiments  and  applications   of    European   radar   data,   most   notably   for   monitoring  in  support  of   icebreaking  and  winter  monitoringin   the   Baltic   Sea. These   efforts   also   provided   various opportunities for  Swedish  industry,  gave  Swedish  research  groups a central position in European organisations for radar data,   and   developed   methods   for   ground-truthing   and   understanding  of   what  radar data  contained  and  could  be  used  for.  By  the  1990s,  the  infrastructure  for  receiving  radar data  expanded.  Experiences  from  the  ERS-satellite  had  been  integrated  as  part  of   the  new  Envisat-programme,  as  well  as  in the parallel development for the airborne CARABAS. The research groups began applying for more sources of  funding,which brought them closer to operational users, like the Coast Guard and the forest industry. This later led to new research questions,   for   example   how   to   study   stem   volume   and   biomass  of   forests,  and  subsequently  the  initiation  of   the  European  satellite  programme BIOMASS.  The  development  of  radar data  has seen  initiatives  on  the  ground,  on  airborne  systems,  and  on  satellites  that  all  remain  relevant  at  present.  Since the   time   for   developing   systems   are   very   long,   sometimes more than a decade, many applications often find their use first on airborne systems and later on satellites. With greater openness in data policy since the 1990s, there are also more  commercial  activities  downstream  for  data  uses.  The  Swedish  research  groups’  involvement  in  new  instruments and  applications  has stimulated  industry  directions,  financing by   SAAB   of   academic   positions,   and established   ESA’s   receiving   station   in   Kiruna.   In   sum,   the   efforts   havestrengthened Sweden’s  role  in  political-  and  climate  relateddiscussions regarding use of  radar remote sensing.

  • Pugh, Rhiannon
    Department of Social and Economic Geography, Uppsala University, Uppsala, Sweden.
    Universities and economic development in lagging regions: ‘triple helix’ policy in Wales2017Ingår i: Regional studies, ISSN 0034-3404, E-ISSN 1360-0591, Vol. 51, nr 7, s. 982-993Artikel i tidskrift (Refereegranskat)
    Abstract [en]

     This paper considers the applicability and relevance of triple helix-based policy and theory, in the weaker region context of Wales,where the success of such approaches has been questionable. It calls for a broader appreciation of the roles ofuniversities in weaker regions beyond a narrow ‘third mission’ conceptualization, moving away from a normativeapplication of the triple helix in contexts very different from those in which it was originated. Instead, it supports thebroadening of the original theory beyond the three key actors of university, government and business, and anincreasing focus on diverse regional settings and spaces.

  • Olson, Maria
    Högskolan i Skövde.
    Utbildning & Lärande 2012:1: Tema: Utmaningar och perspektiv på verksamhetsförlagt lärande2012Samlingsverk (redaktörskap) (Refereegranskat)
  • Emanuel, Martin (Redaktör)
    Gärdebo, Johan (Redaktör)
    Filosofi och historia, KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Filosofi och teknikhistoria, Historiska studier av teknik, vetenskap och miljö.
    Wormbs, Nina (Redaktör)
    Filosofi och historia, KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Filosofi och teknikhistoria, Historiska studier av teknik, vetenskap och miljö.
    Politiken kring svensk rymdverksamhet: Transkript av ett vittnesseminarium på Tekniska museet i Stockholm den 17 januari 20182018Rapport (Övrigt vetenskapligt)
    Abstract [en]

    The  witness  seminar  “Politiken  kring  svensk  rymdverksam-het” (Politics relating to Swedish space activities) was held at Tekniska museet on January 17, 2018, and was led by Lennart Nordh,  assisted  by  Johan  Gärdebo.  The  seminar  focused  on  the relationship between Swedish space activities and various forms of politics, from the 1960s until the 2000s. The discus-sants  presented  various  definitions  of  politics,  recurrently  re-turning  to  the  question  whether  or  not  Sweden  ever  had  a  comprehensive space policy or not. According to the partici-pants,  Swedish  space  activities  have  been  linked  to  their  real  or  perceived  contributions  to  other  policy  areas—research, technology,  foreign  policy,  regional  policy,  and  European  in-tegration—but without a clear overriding political vision per-taining  to  space  specifically.  Initiatives  were  characterized  as  “management  by  opportunities,”  which  implies  making  full  use of opportunities arising in- or outside of the space activi-ties.  In  addition  to  this,  policy-makers,  whether  within  the  Swedish  National  Space  Board,  the  Swedish  Space  Corpora-tion, or the Swedish space industry, have called upon allies in other European governments, organizations and industries, as well  as  individuals  within  the  Swedish  establishment  to  exert  pressure  on  the  Swedish  Government  at  critical  moments.  On other occasions foreign pressure was exerted without any proposals  from  Swedish  actors.  It  was  noted  that  regional  support  for  Kiruna  has  been  important  since  Swedish  space  activities began in the 1960s, and the Esrange space range was established.  The  seminar  identified  several  examples  of  how  policy-makers  within  the  Swedish  space  sector  negotiated  with  governmental  officials  to  gain  support  for projects  and  to expand the scope of space activities into other policy areas. Telecommunication,  remote  sensing  and  meteorology  were  discussed as the main areas in which space technology found operational use—although research and geographic surveying was  also  mentioned.  Since  the  1990s,  the  main  changes  have  been  driven  by  the  Swedish  integration  into  the  European  Union,  the  reduced  Swedish  ownership  in  major  industrial companies, and the increased commercialization of space ac-tivities.  The  previously  dominant  state  funding  was  comple-mented by increasing private financing, and new start-ups be-gan   to   compete   with   previously   established   companies.   Meanwhile, the ability of Swedish state actors to influence the future of Swedish space enterprises has diminished.

  • Disputation: 2018-11-09 09:00 Ekmansalen, Uppsala
    Bogusz, Marcin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Evolutionsbiologi.
    Evolutionary Approaches to Sequence Alignment2018Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Molecular evolutionary biology allows us to look into the past by analyzing sequences of amino acids or nucleotides. These analyses can be very complex, often involving advanced statistical models of sequence evolution to construct phylogenetic trees, study the patterns of natural selection and perform a number of other evolutionary studies. In many cases, these evolutionary studies require a prerequisite of multiple sequence alignment (MSA) - a technique, which aims at grouping the characters that share a common ancestor, or homology, into columns. This information regarding shared homology is needed by statistical models to describe the process of substitutions in order to perform evolutionary inference. Sequence alignment, however, is difficult and MSAs often contain whole regions of wrongly aligned characters, which impact downstream analyses.

    In this thesis I use two broad groups of approaches to avoid errors in the alignment. The first group addresses the analysis methods without sequence alignment by explicitly modelling the processes of substitutions, and insertions and deletions (indels) between pairs of sequences using pair hidden Markov models. I describe an accurate tree inference method that uses a neighbor joining clustering approach to construct a tree from a matrix of model-based evolutionary distances.

    Next, I develop a pairwise method of modelling how natural selection acts on substitutions and indels. I further show the relationship between the constraints acting on these two evolutionary forces to show that natural selection affects them in a similar way.

    The second group of approaches deals with errors in existing alignments. I use a statistical model-based approach to evaluate the quality of multiple sequence alignments.

    First, I provide a graph-based tool for removing wrongly aligned pairs of residues by splitting them apart. This approach tends to produce better results when compared to standard column-based filtering.

    Second, I provide a way to compare MSAs using a probabilistic framework. I propose new ways of scoring of sequence alignments and show that popular methods produce similar results.

    The overall purpose of this work is to facilitate more accurate evolutionary analyses by addressing the problem of sequence alignment in a statistically rigorous manner.

  • Disputation: 2018-11-09 13:00 Brömssalen, Gävle
    Palm, Andreas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Gävleborg.
    Obesity, Sleep and Sleep-disordered Breathing2018Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Background: Sleep problems are associated with impaired quality of life and daytime sleepiness. Obstructive sleep apnoea (OSA) and obesity hypoventilation syndrome (OHS), are associated with metabolic changes and an increased cardiovascular morbidity and mortality. The most preferred treatment of OSA and OHS is positive airway pressure (PAP) therapy. Diagnostic delay and non-adherence to PAP therapy are major clinical problems.

    Aims and methods: Paper I: A longitudinal population-based cohort study aimed to investigate the role of obesity and weight gain in the development of sleep problems in 1,896 men and 5,116 women who responded to questionnaires at baseline and followed up after 10–13 years.

    Paper II: A national registry-based cohort study aimed to analyse gender differences in patients with OHS starting long term mechanical ventilation (LTMV) and to study how the prescription of LTMV due to OHS has changed over time with data on 1,527 patients derived from the Swedish quality registry Swedevox between 1996 and 2014.

    Paper III: A longitudinal observational cohort study aimed to investigate the impact of adherence to continuous positive airway pressure (CPAP) treatment on IGF-1 concentration in 69 patients with OSA followed up after 4.8 ± 2.5 months.

    Paper IV: A national registry-based cohort study aimed to identify protective and risk factors against the discontinuation of CPAP treatment in patients with OSA and to estimate the mortality risk in those who were non-adherent to CPAP therapy on 16,425 patients derived from the Swedish quality registry Swedevox between July 2010 and March 2017.

    Results and conclusions: Weight gain is a risk factor for developing several sleep problems and daytime sleepiness. Women with OHS are older with a more advanced clinical picture at initiation of LTMV and start LTMV more frequently in a non-elective situation than men. CPAP usage ≥ 4 h/night is associated with increased IGF-1 concentration in patients with OSA. Use of humidifier, increasing age, more severe OSA and BMI up to 35 are associated with greater adherence to CPAP treatment. Female gender and coexisting hypertension are risk factors for the discontinuation of CPAP. Failure to adhere to CPAP is associated with increased mortality.

  • Andersson, Roger
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutet för bostads- och urbanforskning (IBF). Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Kulturgeografiska institutionen.
    Musterd, Sako
    University of Amsterdam.
    Galster, George
    Wayne State University.
    Port-of-Entry Neighbourhood and its Effects on the Economic Success of Refugees in Sweden2018Ingår i: International Migration ReviewArtikel i tidskrift (Refereegranskat)
    Abstract [en]

    We investigate the degree to which the ethnic group composition of "port-of-entry neighborhood" (PoE), the first permanent settlement after immigration, affects the employment prospects of refugees in Sweden during the subsequent 10 years. We use panel data on working-age adults from Iran, Iraq, and Somalia immigrating into Sweden from 1995 to 2004. We control for initial individual and labor market characteristics, use instrumental variable regression to avoid bias from geographic selection, and stratify models by gender and co-ethnic employment and education rates within the neighborhood. We find that the impact of co-ethnic neighbors in the PoE varies dramatically by gender.

  • Pettersson, Per
    et al.
    NORCE Norwegian Research Center, Norway.
    Doostan, Alireza
    Aerospace Engineering Sciences, University of Colorado Boulder, USA.
    Nordström, Jan
    Linköpings universitet, Matematiska institutionen, Beräkningsmatematik. Linköpings universitet, Tekniska fakulteten.
    Level Set Methods for Stochastic Discontinuity Detection in Nonlinear Problems2018Rapport (Övrigt vetenskapligt)
    Abstract [en]

    Stochastic physical problems governed by nonlinear conservation laws are challenging due to solution discontinuities in stochastic and physical space. In this paper, we present a level set method to track discontinuities in stochastic space by solving a Hamilton-Jacobi equation. By introducing a speedfunction that vanishes at discontinuities, the iso-zero of the level set problem coincide with the discontinuities of the conservation law. The level set problem is solved on a sequence of successively finer grids in stochastic space. The method is adaptive in the sense that costly evaluations of the conservation law of interest are only performed in the vicinity of the discontinuities during the renement stage. In regions of stochastic space where the solutionis smooth, a surrogate method replaces expensive evaluations of the conservation law. The proposed method is tested in conjunction with different sets of localized orthogonal basis functions on simplex elements, as well as frames based on piecewise polynomials conforming to the level set function. The performance of the proposed method is compared to existing adaptive multi-element generalized polynomial chaos methods.

  • Disputation: 2018-11-09 09:00 CCK Lecture Hall, Stockholm
    Henry, Thomas
    Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum.
    Interlaced proton grid therapy: development of an innovative radiation treatment technique2018Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Spatially fractionated radiotherapy, also known as grid therapy (GRID), has been used for more than a century to try to treat several kinds of lesions. Yet, the grid technique remains a relatively unknown and uncommon treatment modality nowadays. Spatially fractionated beams, instead of conventional homogeneous fields, have been used to exploit the experimental finding that normal tissue can tolerate higher doses when smaller tissue volumes are irradiated. This increase in tolerance with reducing beam size is known as the dose-volume effect. Despite the fact that targets were given inhomogeneous dose distribution, sometimes with some volumes receiving close to no dose, good results in the form of shrinking of bulky tumors have been observed in palliative treatments. The biological processes responsible for this effect are still under discussion, with several possible causes. However, numerous experiments on mice, rats and pigs have confirmed the existence of such effect, which in turn motivates the present development of grid therapy.While mainly photons have been used in grid therapy, proton and ion grid therapies are also emerging as potential alternatives. In this work, an innovative form of grid therapy was proposed. Grids of proton beamlets were interlaced over a target volume with the intention of achieving two main objectives: (1) to keep the grid pattern (made of adjacent high and low doses) from the skin up to the vicinity of the target while (2) delivering nearly homogeneous dose to the target volume. This interlaced proton grid therapy was explored with the use of different beam sizes, from conventional sizes deliverable at modern proton facilities, down to millimeter sized beams. Other considerations that would prevent its clinical use, such as the variable relative biological effectiveness of protons or the use of cone beam computed tomography, were also evaluated. The overall aim was to assess if, and how, such treatment modality could be applied clinically, from a physics and dosimetry point of view. While it presented several theoretical advantages, its potential issues of concern and limitations were also evaluated.

  • Disputation: 2018-11-09 10:00 De Geersalen, Geovetenskapens hus, Stockholm
    Thiessen, Fiona Karen
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för geologiska vetenskaper.
    The evolution of lunar breccias: U-Pb geochronology of Ca-phosphates and zircon using Secondary Ion Mass Spectrometry2018Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Planetary bodies in our Solar System, including the Moon, were exposed to an intense asteroid bombardment between ~4.5-3.8 Ga, shaping their surfaces and leaving visible “footprints” in the form of large impact basins. The end of this period (~4.0-3.85 Ga), might have been marked by a cataclysmic increase in impacts, the so-called Late Heavy Bombardment (LHB), although this remains highly contentious. Since destructive processes, such as tectonics or erosion, have destroyed ancient (> 3.0 Ga) impact structures on Earth, studies of the early Solar System are mainly restricted to lunar samples, because impact structures are much better preserved on the Moon.

    In this thesis, we have therefore analysed impact breccias from three Apollo landing sites (Apollo 12, 14, and 17) with the overall aim to gain a better understanding of the lunar impact history. This endeavour included comprehensive textural and petrological analyses of the breccias and grains of interest (i.e. Ca-phosphates and zircon), as well as obtaining precise U-Pb Secondary Ion Mass Spectrometry (SIMS) ages. The U-Pb ages of Ca-phosphates obtained are consistent with the age of the Imbrium impact at ~3925 Ma, whereas an older age of ~3930 Ma yielded by Ca-phosphates in an Apollo 17 breccia might be linked to the formation of the Serenitatis basin. Furthermore, an impact event at ~3940 Ma was identified in zircon grains in Apollo 14 breccias, which is in agreement with older Ca-phosphate ages yielded in a previous study. The identification of three possible impact events within ~15 myr has important implications for the lunar bombardment history.

    However, there is a possibility that partial Pb loss from older grains during a relatively late event (e.g. Imbrium) might result in apparently older ages in Ca-phosphates. Incomplete resetting of the U-Pb system was recorded in zircon grains in an Apollo 12 breccia, leading to meaningless U-Pb ages which cannot be interpreted unambiguously as either magmatic or as impact events. Nevertheless, the U-Pb ages of several zircon grains occurring in lithic clasts in Apollo 14 breccias can plausibly be linked to magmatic activity, exhibiting several magmatic events between ~4286 Ma and ~4146 Ma. The data obtained in this thesis, together with previously published zircon and Ca-phosphate data, indicate several spikes in the magmatic and impact history during the first ~600 myr of lunar history. This study highlights the importance of combining high-precision age determination with thorough petrological and textural analyses in order to exclude meaningless ages and to interpret the impact and magmatic history of the Moon. 

     

  • Disputation: 2018-11-07 08:53 Vestindien B, Borås
    Goldsmith, David
    Högskolan i Borås, Akademin för textil, teknik och ekonomi.
    WomenWeave Daily: "Artisan Fashion" as "Slow and Sustainable Fashion"2018Doktorsavhandling, monografi (Övrigt vetenskapligt)
    Abstract [sv]

    Allteftersom medvetenheten om de skadliga, ofta dödliga aspekterna av modeproduktion och konsumtion har ökat, har även en global rörelse för att minska miljöskador och kommunicera dess sociala utnyttjande ökat. I alla typer av kommersiella, akademiska och populära diskurser om mode, är ord som miljövänlig, grön, etisk, rättvis och långsam – det sista ett begrepp för allt som inte är ”snabbt mode” – allestädes närvarande. Dessa begrepp är avsedda att representera en mängd sätt att producera och konsumera som sägs, eller hoppas vara, hållbara.

    Denna studie handlar främst om social hållbarhet, eller mänskliga utvecklingsaspekter, av handtillverkat mode, inom textilindustrin. Handtillverkat mode definieras här som både produkt (som en handvävd sjal) och som ett utvecklande modernt modesystem som använder hantverkare på landsbygden i ”utvecklingsländerna” för att göra produkter som vanligtvis säljs till urbana, ”västvärldens” konsumenter. Handtillverkat mode, som försöker överbrygga gamla sätt att producera med nya sätt att konsumera, positioneras i denna forskning såsom det har kommit att ses på modemarknaden: en delmängd av så kallat långsamt och hållbart mode. Även om handtillverkat mode är symboliskt för många långsamma och hållbara ideal, är det akademiskt bristfälligt ifrågasatt och förståelse är låg för hur ”långsam” och ”hållbar” dessa produkter och system faktiskt är.

    Den här fallstudien fokuserar på WomenWeave, en medelstor handvävningsbaserad textilproducent som samtidigt är ett socialt företag i en snabbt föränderlig liten stad på landsbygden i Indien. Denna producent, som sysselsätter cirka 250 individer, mestadels lågutbildade kvinnor med få privilegier, specialiserar sig på naya khadi, en typ av kläder eller inredningstyg vars föregångare, khadi, är en integrerad del av den stora berättelsen om Indiens självständighetsrörelse. Grundat av en ”social entreprenör” med djupa och privilegierade rötter i samhället är fallstudieföretaget idiosynkratiskt, men ändå representativt för ett gemensamt marknadsbaserat ideologiskt tillvägagångssätt för mänsklig utveckling.

    En narrativ, etnografisk metodik användes som inkluderade flera fältbesök, observationer, intervjuer och deltagande interaktioner med fallstudieföretagets ledning, managers, hantverkare, produktdesigners, partners och experter, bland annat. Det empiriska resultatet presenteras, analyseras och diskuteras med hjälp av aktivitetsteori och en modifierad modell av Osterwalder och Pingeur’s Business Model Canvas.

    Medan nomenklaturen för ”långsamt och hållbart mode” avvisas, åtminstone för närvarande, visar studien att med professionell ledning och management, anammandet av ”global design” känsla för mode och andra snabba moderniteter, uppfyller systemet sitt lokala uppdrag att tillhandahålla inkomster och främja social integration.

  • Dalton, Jacob
    et al.
    KTH, Skolan för elektro- och systemteknik (EES), Elkraftteknik.
    Herre, Lars
    KTH, Skolan för elektro- och systemteknik (EES), Elkraftteknik.
    Söder, Lennart
    KTH, Skolan för elektro- och systemteknik (EES), Elkraftteknik.
    Exploring the Business Case of a Risk-Averse Electric Vehicle Aggregator in the Nordic Market2018Konferensbidrag (Refereegranskat)
    Abstract [en]

    The Nordic power system is facing the challenge of the ongoing decrease of synchronous generation along with increased penetration of inverter based renewable generation leading to reduced system inertia. Meanwhile, the electrification of the transport sector will result in a significant amount of additional electrical loads. However, the electrification of private transport is a technology of growing interest that can provide flexibility to the power system if adequately utilized. Electric vehicles (EV) can be considered as temporary energy storage with availability, energy and capacity constraints.

    In this paper, we use first hand data of a real EV fleet of Tesla vehicles and their historical driving patterns to develop a two-stage stochastic optimization problem. This model maximizes the profit of a risk-averse EV aggregator that aims to place optimal bids on the day ahead in both energy and Frequency Containment Reserve (FCR) markets. Only uni-directional charging is examined, while we take into account uncertainty from prices and vehicle utilization. Case studies are carried out modelling individual vehicle driving behavior in different Nordic price areas in both winter and summer.

    We identify a strong alignment of EV availability and periods of high FCR prices. Results show that consumption is shifted largely towards early hours of the morning. When compared to a  reference ”cost of charging case”, up to 50% of the cost of charging can be covered in Norway, while the entire cost is met in Sweden.

  • Disputation: 2018-11-07 13:00 Aula Anatomica (Bio.A.206), Umeå
    Östman, Marcus
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Antimicrobials in sewage treatment plants: occurrence, fate and resistance2018Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    The World Health Organization (WHO) has identified antibiotic resistance as a major threat to human health. The environment has been suggested to play an important role in the emergence of antibiotic resistant bacteria. The external environment can act as a source of resistance genes that could potentially be transferred into human pathogens. It is also an important route for the dissemination of antibiotic resistance genes and bacteria. Sewage treatment plants (STPs) are among the most important routes by which antibiotics and antibiotic resistance genes enter the environment. It has been suggested that STPs are hotspots for the development of antibiotic resistance because they contain relatively high concentrations of antibiotics as well as both human and environmental bacteria. Further complicating matters, there is evidence that other substances with antimicrobial properties, such as biocides and metals, can cause antibiotic resistance due to co- and cross-resistance.

    This thesis contributes new knowledge on the concentrations, mass flows, and removal efficiencies of antimicrobials in STPs and their connections to the emergence of antibiotic resistance. Paper I presents data on the levels of 40 different antimicrobials in the incoming wastewater, treated effluent, and digested sludge of eleven different STPs. Although not previously detected in STPs, chlorhexidine is shown to be ubiquitous in such plants. In Paper II, mass flows and removal efficiencies are calculated for eleven antimicrobials over various treatment steps in three STPs, showing that polar antimicrobials were inefficiently removed from the wastewater. In Paper III, the minimum selective concentration (MSC) for the antibiotic tetracycline was determined in a complex bacterial aquatic biofilm using both phenotypic and genotypic endpoints. It was found that 10 µg/L selected for phenotypic resistance, and 1 µg/L selected for certain resistance genes. Paper VI used metagenomics to determine whether there is selection for antibiotic-resistant bacteria in STPs and whether the extent of this selection can be correlated to the concentrations of antimicrobial compounds. No clear evidence for selection was identified. Paper V evaluates advanced wastewater treatment techniques for removing antimicrobial compounds using ozonation and granular activated carbon (GAC). The identity of the GAC material was found to strongly affect removal efficiency, and GAC was more efficient than ozonation for most compounds at the tested concentrations.

  • Eklöf, Jenny Katarina
    Umeå universitet, Humanistiska fakulteten, Institutionen för idé- och samhällsstudier.
    Bokrecension: Why Students Resist Learning. A Practical Model for Understanding and Helping Students2018Ingår i: Högre Utbildning, ISSN 2000-7558, E-ISSN 2000-7558, Vol. 8, nr 2, s. 69-71Artikel, recension (Övrigt vetenskapligt)
  • Aramo-Immonen, Heli
    Tampere University of Technology, Tampere, Finland.
    Project management ontology: the organizational learning perspective2009Doktorsavhandling, monografi (Övrigt vetenskapligt)
    Abstract [en]

    In a recent interview with the Financial Times, the chief executive of Royal Dutch Shell, Mr. Jeroen van der Veer, said he “keeps faith in ‘elephant’ projects” referring to the Russian gas mega-project that Shell had fallen eight months behind schedule with and had cost overruns twice the original estimate. Mr. van der Veer partially blamed industry-wide factors for this such as an increase in raw material prices, more expensive contractors and exchange rate pressure. But he also implied that the original assessment of the project in 2003 had been too optimistic and that the scope of the mega-project had to be revised. The wisdom he said was that scope changes are basically because you didn’t do enough homework in advance. Even though it is rather easy to feel miserable after such a statement, there is faith left as the chief executive says - if only we had been able to do our homework. This gives me reason enough to concentrate in this research on the construction of a proactive qualitative decision support aid for mega-project management. The main research topic of the dissertation is organizational learning in the field of project management (PM). This study explores project management by providing a PM ontology for managers. The managerial value of the ontology is, for example, lower potential for time and cost overruns and poor project quality, and higher potential for effective and efficient execution of complex projects. Project management essentially aims to combine learning and performance within the project organization to serve the project owners’ strategy. Therefore a proactive vision and co-evolutionary touch is needed to evolve project processes. Project management under high pressure often means utilizing explicit quantitative methods, usually based on reactive calculations. However, the management of uncertainties and risks demands a versatile, qualitative point of view. With quantitative methods we can “price” the risks. With qualitative methods we are able to realize and shape the risks in advance. Therefore project management is the challenge to move the organization towards the common qualitative and quantitative goals during a project lifecycle, i.e. to support organizational learning throughout a long-lasting project. This study introduces a project management ontology – a classification of management disciplines for project managers and a project learning model. Knowledge management theory, activity theory, systems theory and various management practices are discussed in the conceptual part of this thesis. The empirical part of the research concerns a multiple-case study conducted in ten project organizations participating in two large mega-projects. The mega-projects were in the offshore industry and shipbuilding industry. Altogether more than fifty project managers and project team members participated in this research. The empirical results are presented at the end of the introductory essay and in the original publications enclosed in this thesis. Appendixes available from: heli.aramo-immonen@tut.fi

  • Wikman, K. Rob. V.
    Nordiska museet.
    Louise Hagberg1945Ingår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1945, s. 171-174Kapitel i bok, del av antologi (Övrigt vetenskapligt)
  • Sjöstedt, Yngve
    Alarik Behm1945Ingår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1945, s. 167-170Kapitel i bok, del av antologi (Övrigt vetenskapligt)
  • Lindblom, Andreas
    Nordiska museet.
    Rudolf Cederström1945Ingår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1945, s. 165-166Kapitel i bok, del av antologi (Övrigt vetenskapligt)
  • Enell, Jacob
    et al.
    Umea Univ, Dept Surg & Perioperat Sci, S-90185 Umea, Sweden.
    Bayadsi, Haytham
    Umea Univ, Dept Surg & Perioperat Sci, S-90185 Umea, Sweden.
    Lundgren, Ewa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Endokrinkirurgi.
    Hennings, Joakim
    Umea Univ, Dept Surg & Perioperat Sci, S-90185 Umea, Sweden.
    Primary Hyperparathyroidism is Underdiagnosed and Suboptimally Treated in the Clinical Setting2018Ingår i: World Journal of Surgery, ISSN 0364-2313, E-ISSN 1432-2323, Vol. 42, nr 9, s. 2825-2834Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    To evaluate whether patients presenting with laboratory results consistent with primary hyperparathyroidism (pHPT) are managed in accordance with guidelines. The laboratory database at a hospital in Sweden, serving 127,000 inhabitants, was searched for patients with biochemically determined pHPT. During 2014, a total of 365 patients with biochemical laboratory tests consistent with pHPT were identified. Patients with possible differential diagnoses or other reasons for not being investigated according to international guidelines were excluded after scrutinizing records, after new blood tests, and clinical assessments by endocrine surgeons. Altogether, 92 patients had been referred to specialists and 82 had not. The latter group had lower serum calcium (median 2.54 mmol/L) and PTH (5.7 pmol/L). Out of these 82 cases, 9 patients were diagnosed with pHPT or had some sort of long-term follow-up planned as outpatients. Primary hyperparathyroidism is overlooked and underdiagnosed in a number of patients in the clinical setting. It is important to provide local guidelines for the management of patients presenting with mild pHPT to ensure that these patients receive proper evaluation and follow-up according to current research.

  • Disputation: 2018-11-08 10:15 Lindahlsalen, 05:01058, EBC, Uppsala
    Naidoo, Thijessen
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Människans evolution.
    Population Genetics of Human Genomic Elements2018Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    The genomes of living organisms are composed of a multitude of functional units, which interact with each other and their environment in a highly regulated fashion, to facilitate the expression of an enduring (and evolving) phenotype. Several approaches have emerged in the effort to identify these functional units and explore their activities. In this thesis, I have taken a population genetics approach; evaluating how the distribution of genetic variation in the human genome has been shaped through the actions of natural selection on functional genomic elements. In the first paper, I interrogate a catalogue of elements derived from biochemical signatures for signals of selection; finding significant signals of purifying selection on regulatory elements, independent of linked-purifying selection. In the second paper, I explore the pseudogene class of genomic elements, and find that a large proportion of a particular subclass, transcribed duplicated pseudogenes, has experienced significant amounts of positive selection. In the third paper, I focus on protein coding genes and variants that disrupt their open reading frames. Specifically, I examine the distribution of loss-of-function variants in the Khoe-San population; gauging their functional significance and exploring the biological roles of affected genes. In the final paper, instead of using population genetics to uncover and explore genomic elements, I use a major genomic element – the Y chromosome – as an effective tool to study the evolutionary history of a human population.

  • Bonde, Knut
    Herrskap i Sörmland: ur en brevväxling från 1800-talets början1945Ingår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1945, s. 151-164Kapitel i bok, del av antologi (Övrigt vetenskapligt)
  • Becker, Per
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för samhällsvetenskap. Lund University.
    Dependence, trust, and influence of external actors on municipal urban flood risk mitigation: The case of Lomma Municipality, Sweden2018Ingår i: International Journal of Disaster Risk Reduction, E-ISSN 2212-4209, Vol. 31, s. 1004-1012Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Floods constitute a major problem that cross geopolitical, administrative, and sectoral boundaries, and must as such be jointly governed by a web of actors. The patterns of social relations among these actors are fundamental for society's capacity to mitigate flood risk. The purpose of this study is to contribute to our understanding of flood risk governance by investigating the social organization of formal actors that contribute to mitigating urban flood risk in Swedish municipalities. It applies Social Network Analysis to examine what patterns of dependence, trust, and influence of external actors emerge in the accounts of politicians and civil servants in Lomma Municipality, Sweden. The results indicate interesting patterns in type of input, as well as the role of personal relationships and different forms of authority for trust and influence. There is also a horizontal decoupling between municipalities along the river, as well as a vertical decoupling between the municipal and the national level, where withdrawing national authorities leave a void increasingly filled by private companies. These patterns of social relationships between municipal and external actors contributing to mitigate urban flood risk are important for understanding flood risk governance in society. 

  • Cárdenas, Paco
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Systematisk biologi.
    Moore, Jon A.
    Wilkes Honors College, Florida Atlantic University.
    First records of Geodia demosponges from the New England seamounts, an opportunity to test the use of DNA mini-barcodes on museum specimens2017Ingår i: Marine Biodiversity, ISSN 1867-1616, E-ISSN 1867-1624Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We report the first records of the sponge genus Geodia (Demospongiae, Tetractinellida, Geodiidae) from the New England Seamounts and Muir Seamount, at lower bathyal depths. Nine specimens collected between 2000 and 2005 belong to two boreal species (Geodia macandrewii and Geodia barretti) and a temperate species (Geodia megastrella). These records extend the distributions of these deep-sea amphi-Atlantic species to the west. Most of these specimens were originally fixed in formalin, which substantially degraded the DNA. We nonetheless managed to sequence two cytochrome c oxidase subunit I (COI) mini-barcodes: the universal mini-barcode at the 5′ end of the Folmer barcode (130 bp) and a newly proposed mini-barcode at the 3′ end of the Folmer barcode (296 bp). These mini-barcodes unambiguously confirmed our identifications. As an additional test, we also successfully sequenced these two mini-barcodes from the holotype of G. barretti, collected in 1855. We conclude by advocating the use of mini-barcodes on formalin-fixed or old specimens with degraded DNA.

  • Simic, Nino
    et al.
    Marklund, Kristin
    Jönsson, Ann
    Lagercrantz, Helena
    Erichsen, David
    Rask, Joan
    Björkqvist, Jeanette
    Kvaal, Bjørn
    Ólafsdóttir, Annska
    Ny i Norden: Vägen till arbete2018Övrigt (Övrig (populärvetenskap, debatt, mm))
    Abstract [sv]

    I den här rapporten beskriver vi insatser för att uppnå snabbare integration av flyktingar och utrikesfödda på arbetsmarknaden i Norden. De exempel som presenteras i rapporten har valts ut av projektets nordiska expertgrupp. I valet av exempel har expertgruppens medlemmar fokuserat på de integrationsinsatser som bedöms ha störst möjlighet att implementeras i grannländerna. Urvalet bygger på kunskap från forskning och rekommendationer från våra nordiska samarbetspartners.

    I rapporten har vi även strävat efter att kortfattat redogöra för aktuell forskning och kunskap om effektiva åtgärder samt de utmaningar som flyktingar kan möta på arbetsmarknaderna i Norden. Läs mer på www.integrationnorden.org

  • Simic, Nino
    et al.
    Marklund, Kristin
    Jönsson, Ann
    Lagercrantz, Helena
    Lagercrantz, Caroline
    Erichsen, David
    Rask, Joan
    Björkqvist, Jeanette
    Kvaal, Bjørn
    Ólafsdóttir, Annska
    New in the Nordic countries: Work inclusion of Migrants2018Övrigt (Övrig (populärvetenskap, debatt, mm))
    Abstract [en]

    In this report, we describe efforts to achieve faster integration of refugees and foreign-born residents in the labour market in the Nordic region. The examples presented in the report have been selected by our group of Nordic experts. In selecting examples, they have focused on the integration initiatives deemed to have the greatest likelihood of being implemented in their neighbouring countries. This selection is based on the knowledge gained from research and the recommendations made by our Nordic co-operation partners.

    In this report we have also sought to give a brief description of current research and knowledge regarding effective measures and the possible challenges facing refugees in the labour markets in the Nordic Region.

    For more information visit www.integrationnorden.org

  • Kurdve, Martin
    et al.
    RISE - Research Institutes of Sweden, Swerea, Swerea IVF AB. Chalmers University of Technology, Sweden.
    Jönsson, Christina
    RISE - Research Institutes of Sweden, Swerea, Swerea IVF AB.
    Granzell, Ann-Sofie
    Development of the urban and industrial symbiosis in western Mälardalen2018Ingår i: Procedia CIRP, ISSN 2212-8271, E-ISSN 2212-8271, Vol. 73, s. 96-101Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    From a product service systems business model development perspective, this paper presents a case study of Västra Mälardalens industrial symbiosis, its maturity level and potentials for further development. The status and potentials of the symbiosis network, based on a survey, interviews and workshops, together with background statistics, is used to evaluate the potential improvement areas and suggest future research. The study contributes with application of evaluation models and confirms earlier research and in addition suggests future research in the field. The Symbiosis network has potential to be acting as innovation catalyst supporting companies to go beyond core business development.

  • Kurdve, Martin
    et al.
    RISE - Research Institutes of Sweden, Swerea, Swerea IVF AB. Chalmers University of Technology, Sweden.
    Hildenbrand, Jutta
    RISE - Research Institutes of Sweden, Swerea, Swerea IVF AB.
    Jönsson, Christina
    RISE - Research Institutes of Sweden, Swerea, Swerea IVF AB.
    Design for green lean building module production - Case study2018Ingår i: Procedia Manufacturing, E-ISSN 2351-9789, Vol. 25, s. 594-601Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    With an increasing societal need for temporary buildings, while construction industry faces resource and time efficiency challenges, factory assembly of modular buildings can be a solution. This case study at a start-up company uses experiences from assembly system design and eco-design literature to propose green lean design principles to be used in the design and development of building modules and their assembly stations. The eco-design strategy wheel is used as a basis and adapted for the assessment of green and lean building manufacturing.