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  • Hagman, A.
    et al.
    Hagman, A.
    Nygårds, Mikael
    RISE, Innventia.
    Thermographical Analysis of Paper During Tensile Testing and Comparison to Digital Image Correlation2016Ingår i: Experimental mechanics, ISSN 0014-4851, E-ISSN 1741-2765, 1-15 s.Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The thermal response in paper has been studied by thermography. It was observed that an inhomogeneous deformation pattern arose in the paper samples during tensile testing. In the plastic regime a pattern of warmer streaks could be observed in the samples. On the same samples digital image correlation (DIC) was used to study local strain fields. It was concluded that the heat patterns observed by thermography coincided with the deformation patterns observed by DIC. Because of its fibrous network structure, paper has an inhomogeneous micro-structure, which is called formation. It could be shown that the formation was the cause of the inhomogeneous deformations in paper. Finite element simulations was used to show how papers with different degrees of heterogeneity would deform. Creped papers, where the strain at break has been increased, were analysed. For these paper it was seen that an overlaid compaction of the paper was created during the creping process. During tensile testing this was recovered as the paper network structure was strained.

  • Brosché, Johan
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för freds- och konfliktforskning.
    Brosché, Johan
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för freds- och konfliktforskning.
    Kreutz, Joakim
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för freds- och konfliktforskning.
    Legnér, Mattias
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Konstvetenskapliga institutionen, Kulturvård.
    Kulturarv i skottgluggen2016Övrigt (Övrig (populärvetenskap, debatt, mm))
    Abstract [sv]

    ANALYS Den Islamiska staten attacker mot Palmyra och andra kulturarv i Syrien och Irak har fått stor uppmärksamhet i internationella medier. Men attacker mot kulturarv i väpnade konflikter är inte unikt för IS, och dessa attacker kan ha en rad olika syften. Det skriver Johan Brosché, Joakim Kreutz och Mattias Legner utifrån ett nytt tvärvetenskapligt forskningsprojekt.

  • Disputation: 2017-02-10 09:00 Hugo Theorell, Linköping
    Rejmstad, Peter
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska fakulteten.
    Rejmstad, Peter
    Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska fakulteten.
    Optical Monitoring of Cerebral Microcirculation2017Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    The cerebral microcirculation consists of a complex network of small blood vessels that support nerve cells with oxygen and nutrition. The blood flow and oxygen delivery in the microcirculatory blood vessels are regulated through mechanisms which may be influenced or impaired by disease or brain damage resulting from conditions such as brain tumors, traumatic brain injury or subarachnoid hemorrhage (SAH). Monitoring of parameters relating to the microvascular circulation is therefore needed in the clinical setting. Optical techniques such as diffuse reflectance spectroscopy (DRS) and laser Doppler flowmetry (LDF) are capable of estimating the oxygen saturation (SO2) and tracking the microvascular blood flow (perfusion) using a fiber optic probe. This thesis presents the work carried out to adapt DRS and LDF for monitoring cerebral microcirculation in the human brain.

    A method for real-time estimation of SO2 in brain tissue was developed based on the P3 approximation of diffuse light transport and quadratic polynomial fit to the measured DRS signal. A custom-made fiberoptic probe was constructed for measurements during tumor surgery and in neurointensive care. Software modules with specific user interface for LDF and DRS were programmed to process, record and present parameters such as perfusion, total backscattered light, heart rate, pulsatility index, blood fraction and SO2 from acquired signals.

    The systems were evaluated on skin, and experimentally by using optical phantoms with properties mimicking brain tissue. The oxygen pressure (pO2) in the phantoms was regulated to track spectroscopic changes coupled with the level of SO2. Clinical evaluation was performed during intraoperative measurements during tumor surgery (n = 10) and stereotactic deep brain stimulation implantations (n = 20). The LDF and DRS systems were also successfully assessed in the neurointensive care unit for a patient treated for SAH. The cerebral autoregulation was studied by relating the parameters from the optical systems to signals from the standard monitoring equipment in neurointensive care.

    In summary, the presented work takes DRS and LDF one step further toward clinical use for optical monitoring of cerebral microcirculation.

  • Holland, Petter
    et al.
    Holland, Petter
    Knaevelsrud, Helene
    Soreng, Kristiane
    Mathai, Benan J.
    Lystad, Alf Hakon
    Pankiv, Serhiy
    Bjorndal, Gunnveig T.
    Schultz, Sebastian W.
    Lobert, Viola H.
    Chan, Robin B.
    Zhou, Bowen
    Liestol, Knut
    Carlsson, Sven R.
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.
    Melia, Thomas J.
    Di Paolo, Gilbert
    Simonsen, Anne
    HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels2016Ingår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 7, 13889Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A fundamental question is how autophagosome formation is regulated. Here we show that the PX domain protein HS1BP3 is a negative regulator of autophagosome formation. HS1BP3 depletion increased the formation of LC3-positive autophagosomes and degradation of cargo both in human cell culture and in zebrafish. HS1BP3 is localized to ATG16L1-and ATG9-positive autophagosome precursors and we show that HS1BP3 binds phosphatidic acid (PA) through its PX domain. Furthermore, we find the total PA content of cells to be significantly upregulated in the absence of HS1BP3, as a result of increased activity of the PA-producing enzyme phospholipase D (PLD) and increased localization of PLD1 to ATG16L1-positive membranes. We propose that HS1BP3 regulates autophagy by modulating the PA content of the ATG16L1-positive autophagosome precursor membranes through PLD1 activity and localization. Our findings provide key insights into how autophagosome formation is regulated by a novel negative-feedback mechanism on membrane lipids.

  • Pöppel, Ludmila
    Stockholms universitet, Humanistiska fakulteten, Institutionen för slaviska och baltiska språk, finska, nederländska och tyska, Slaviska språk.
    Pöppel, Ludmila
    Stockholms universitet, Humanistiska fakulteten, Institutionen för slaviska och baltiska språk, finska, nederländska och tyska, Slaviska språk.
    Dobrovol'skij, Dmitrij
    Stockholms universitet, Humanistiska fakulteten, Institutionen för slaviska och baltiska språk, finska, nederländska och tyska, Slaviska språk.
    Конструкции то-то и N, в том-то и N, в том-то и весь <весь и> N: корпусное исследованиеConstructions to-to i N, v tom-to i N, v tom-to i ves’ <ves’ i> N: a corpus study2016Ingår i: Vestnik Novosibirskogo gosudarstvennogo pedagogicheskogo universiteta, ISSN 2226-3365, nr 2, 61-72 s.Artikel i tidskrift (Refereegranskat)
    Abstract [ru]

    Целью настоящего исследования является проверка гипотезы о природе лексической словосочетаемости. В соответствии с традиционными представлениями словосочетания могут быть либо свободными, либо устойчивыми. Причем понятие устойчивости традиционно связывается с понятием неаддитивности смыслов. Значение свободного словосочетания выводится из значений входящих в него элементов, в отличие от устойчивого словосочетания, значение которого не выводится из его составляющих, т. е. не является ни композиционным, ни аддитивным. С появлением больших корпусов текстов и развитием новых лингвистических направлений, таких как грамматика конструкций, открылись возможности исследования частоты употребления языковых единиц и их когнитивной укорененности эмпирическими методами, в том числе с помощью статистических методов. В статье будет показано, что устойчивость словосочетаний не обязательно связана с некомпозиционностью. Многие конструкции, образуемые согласно правилам управления элементами словосочетания, могут тем не менее храниться в памяти как самостоятельные единицы. С помощью больших корпусов текстов, позволяющих получить обширный эмпирический материал, будут проанализированы семантически близкие конструкции то-то и N, в том-то и N и в том-то и весь <весь и> N и их реализации и будет показано, что некоторые реализации конструкций настолько частотны, что их можно считать когнитивно укорененными единицами, хранящимися в памяти как самостоятельные единицы языка. Соответственно, их следует описывать как отдельные единицы лексикона. Будут также выявлены некоторые закономерности распределения филлеров слота N рассматриваемых конструкций и сформулированы соответствующие правила такого распределения.

  • Baumann, Anne
    et al.
    Baumann, Anne
    Jorge-Finnigan, Ana
    Jung-KC, Kunwar
    Sauter, Alexander
    Horvath, Istvan
    Morozova-Roche, Ludmilla A.
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.
    Martinez, Aurora
    Tyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity2016Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, 39488Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine neurotransmitters and hormones, binds to negatively charged phospholipid membranes. Binding to both large and giant unilamellar vesicles causes membrane permeabilization, as observed by efflux and influx of fluorescence dyes. Whereas the initial protein-membrane interaction involves the N-terminal tail that constitutes an extension of the regulatory ACT-domain, prolonged membrane binding induces misfolding and self-oligomerization of TH over time as shown by circular dichroism and Thioflavin T fluorescence. The gradual amyloid-like aggregation likely occurs through cross-beta interactions involving aggregation-prone motives in the catalytic domains, consistent with the formation of chain and ring-like protofilaments observed by atomic force microscopy in monolayer-bound TH. PC12 cells treated with the neurotoxin 6-hydroxydopamine displayed increased TH levels in the mitochondrial fraction, while incubation of isolated mitochondria with TH led to a decrease in the mitochondrial membrane potential. Furthermore, cell-substrate impedance and viability assays showed that supplementing the culture media with TH compromises cell viability over time. Our results revealed that the disruptive effect of TH on cell membranes may be a cytotoxic and pathogenic factor if the regulation and intracellular stability of TH is compromised.

  • Disputation: 2017-02-17 13:00 Temcas, hus T, Linköping
    Söderström, Sara
    Linköpings universitet, Institutionen för tema.
    Söderström, Sara
    Linköpings universitet, Institutionen för tema.
    Regional Environmental Governance and Avenues for the Ecosystem Approach to management in the Baltic Sea Area2017Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    This thesis explores the avenues for the ecosystem approach to management in theBaltic Sea Region. This region is one of the most contaminated water bodies inthe world, although the first Regional Seas Convention was created here and theregion has a long history of cooperation and environmental protection. Thecurrent environmental governance arrangements are examined with specific focuson governance structures, cross-sectoral integration and ecological boundaries.The ecosystem approach to management as both a tool and vision of holisticmanagement of natural resources is traced through the evolution of environmentalgovernance, as well as its manifestation in contemporary environmental policiesin the region. It is found that the major EU directives, as well as HELCOMpolices, promote the ecosystem approach and that its presence has increased inrecent years; it is now the major guiding principle in European marinegovernance. However, the governance structures impede implementation indifferent ways. The environmental problem areas in the region all require differentgovernance arrangements, thus obstructing a holistic approach. The environmentalproblems per se also affect each other, necessitating far-reaching sectoralintegration and cross-border cooperation, which at present is the major obstacleregarding implementation. The contemporary trends combining solidregionalisation through HELCOM with increased Europeanisation and macroregionalisationby different EU initiatives offer some promise, but the crosssectoralimpediments must be resolved if the ecosystem approach is to become apractical approach and not just a policy principle.

  • Disputation: 2017-02-17 13:00 Sal B, Stockholm
    Yang, Yanpeng
    KTH, Skolan för informations- och kommunikationsteknik (ICT), Kommunikationssystem, CoS, Radio Systems Laboratory (RS Lab).
    Yang, Yanpeng
    KTH, Skolan för informations- och kommunikationsteknik (ICT), Kommunikationssystem, CoS, Radio Systems Laboratory (RS Lab).
    A study on the deployment and cooperative operation of ultra-dense networks2017Licentiatavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    The traffic volume in wireless communication has grown dramatically inthe last decade. Recent predictions indicate such data storm will be evenmore violent in the short run. Potential solutions for accommodating therapid traffic growth can be summed up into three categories: broadeningthe available bandwidth, improving the spectral efficiency, and densifying theinfrastructure. In this thesis, we focus on the densification dimension whichhas been proved to be the most effective in the past. The current gain ofnetwork densification mainly comes from cell splitting, thereby serving moreuser equipments (UEs) simultaneously. This trend will decelerate as basestation (BS) density gets closer to or even surpass UE density which forms aultra-dense network (UDN). Thus, it is crucial to understand the behavior ofultra-densification for future network provisioning.An important question for future system design and operating strategy iswhich element is more effective than others. To this end, we start from comparingthe effectiveness of densification with spectrum expansion and multiantennasystems in terms of meeting certain traffic demand. Our findingsshow that deploying more BSs provides a substantial gain in sparse networkbut the gain decreases progressively in a UDN. Therefore, adding multiantennason BSs or utilizing additional spectrum are more favorable thanfurther densification in a UDN. The impact of traffic types is also discussed.Even with the same area throughput, different combinations of individualthroughput and UE density lead to different requirements for resources.The diminishing gain appears in a UDN make us curious to know if thereexists a terminal on the way of densification. Such uncertainty leads to thestudy on the asymptotic behavior of densification in the next part of thethesis. We incorporate a sophisticated bounded dual-slope path loss modeland practical UE densities in our analysis. By using stochastic geometry,we derive the expressions of the coverage probability of a typical UE andnetwork area spectral efficiency (ASE). In addition, we present the asymptoticbehavior of ultra-densification: the coverage probability and ASE have nonzeroconvergence in asymptotic regions unless UE density goes to infinity (fullload).Previous UDN studies focus on single BS association rule which resultsin a large portion of dormant BSs in the network. Thus, whether we canutilize these dormant BSs to improve system performance is an interestingquestion. To this end, we employ joint transmission (JT) techniques into aUDN. Two types of cooperation schemes are investigated: non-coherent JTand coherent JT depending on the availability of channel state information(CSI). Our results reveal that non-coherent JT is not beneficial in a UDNdue to the simultaneous increase in both desired signal and interference. Coherentcooperative transmissions with CSI are able to increase UE spectralefficiency (SE) depending on the environmental characteristics captured bycritical distance and path loss exponents.

  • Nielsen, Anne Sofie Elberg
    et al.
    COWI A/S.
    Nielsen, Anne Sofie Elberg
    COWI A/S.
    Sand, Henrik
    COWI A/S.
    Sørensen, Pernille
    COWI A/S.
    Knutsson, Mikael
    University of Gothenburg.
    Martinsson, Peter
    University of Gothenburg.
    Persson, Emil
    University of Gothenburg.
    Wollbrant, Conny
    University of Gothenburg.
    Nudging and pro-environmental behaviour2017Bok (Övrigt vetenskapligt)
    Abstract [en]

    This study explores how nudging instruments are used to encourage environmentally friendly behavior within energy consumption, waste management and resource efficiency. The study results provide very interesting examples of nudging resulting in reduced energy consumption in households due to providing real-time information, peer comparison and the use of green defaults, as well as increased and improved quality of waste sorting and reduction of food waste through changes in the physical environment. The study also presents the results of a field experiment examining how nudges can encourage consumers in a super market to choose to donate the deposit refunded from reverse-vending machines for beverage containers to an environment friendly cause. Overall, the findings of this study provide a strong case for using nudging instruments to promote more environmentally frien

  • Nurmi, Emma
    et al.
    Nurmi, Emma
    Jakobsen, Dorte Skjøtt
    Langset, Beate
    Eriksson, Margareta
    Kollberg, Pär
    Rainio, Kaija
    Shipments of green-listed waste: a Nordic survey2017Bok (Övrigt vetenskapligt)
    Abstract [en]

    This project was carried out to provide a better picture of transboundary shipments of green-listed waste involving project countries Denmark, Finland, Norway, and Sweden. The readily available export data for 2014 are presented. The primary effort in the project was devoted to an Annex VII inspection, which was carried out as a desk study. 33 companies were asked to send all their Annex VIIs and related contracts from September-October 2015 to the competent authority of their country. Special focus was given to companies exporting waste beyond the EEA, as were the waste streams consisting of metal scrap, plastics, paper, and cable waste. In addition to the Annex VII inspection and the gathering of national statistics, the project included asking company representatives about their practices and opinions related to green-listed waste shipments, via a Web-based survey.

  • Disputation: 2017-02-09 13:00 sal 14, hus 5, Kräftriket, Stockholm
    Robbestad Gylterud, Håkon
    Stockholms universitet, Naturvetenskapliga fakulteten, Matematiska institutionen.
    Robbestad Gylterud, Håkon
    Stockholms universitet, Naturvetenskapliga fakulteten, Matematiska institutionen.
    Univalent Types, Sets and Multisets: Investigations in dependent type theory2017Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    This thesis consists of four papers on type theory and a formalisation of certain results from the two first papers in the Agda language. We cover topics such as models of multisets and sets in Homotopy Type Theory, and explore ideas of using type theory as a language for databases and different ways of expressing dependencies between terms. The two first papers build on work by Aczel 1978. We establish that the underlying type of Aczel’s model of set theory in type theory can be seen as a type of multisets from the perspective of Homotopy Type Theory, and we identify a suitable subtype which becomes a model of set theory in which equality of sets is the identity type. The third paper is joint work with Henrik Forssell and David I .Spivak and explores a certain model of type theory, consisting of simplicial complexes, from the perspective of database theory. In the fourth and final paper, we consider two approaches to unraveling the dependency structures between terms in dependent type theory, and formulate a few conjectures about how these two approaches relate.

  • Ceragioli, Francesca
    et al.
    Politécnico di Torino, Dip. di Mathematica.
    Ceragioli, Francesca
    Politécnico di Torino, Dip. di Mathematica.
    Lindmark, Gustav
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska fakulteten.
    Clas, Veibäck
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska fakulteten.
    Wahlström, Niklas
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska fakulteten.
    Lindfors, Martin
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska fakulteten.
    Altafini, Claudio
    Linköpings universitet, Institutionen för systemteknik, Reglerteknik. Linköpings universitet, Tekniska fakulteten.
    A bounded confidence model that preserves the signs of the opinions2016Ingår i: Proceedings of the 2016 European Control Conference, Institute of Electrical and Electronics Engineers (IEEE), 2016, 543-548 s.Konferensbidrag (Refereegranskat)
    Abstract [en]

    The aim of this paper is to suggest a modification to the usual bounded confidence model of opinion dynamics, so that “changes of opinion” (intended as changes of the sign of the initial state) of an agent are never induced by the dynamics. In order to do so, a bipartite consensus model is used, endowing it with a confidence range. The resulting signed bounded confidence model has a state-dependent connectivity and a behavior similar to its standard counterpart, but in addition it preserves the sign of the opinions by “repelling away” opinions localized near the origin but on different sides with respect to 0.

  • Disputation: 2017-02-03 10:00 F3, Stockholm
    Futrzynski, Romain
    KTH, Skolan för teknikvetenskap (SCI), Farkost och flyg. KTH, Skolan för teknikvetenskap (SCI), Centra, Linné Flow Center, FLOW.
    Futrzynski, Romain
    KTH, Skolan för teknikvetenskap (SCI), Farkost och flyg. KTH, Skolan för teknikvetenskap (SCI), Centra, Linné Flow Center, FLOW.
    Effect of drag reducing plasma actuators using LES2017Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [sv]

    Arbetet som utförts i denna avhandling undersöker nya sätt att minska luftmotstånd hos markfordon. Speciellt undersöks numeriskt effekten av plasmaaktuatorer med avsikten att uppnå fördröjd separation av strömningen kring en halvcylinder, en geometri vald för att representera en förenklad A-stolpe på en lastbil. 

    För att kunna utföra studien behöver plasmaaktuatorer kunna ingå i beräkningar av turbulenta strömningsfält. Därför undersöks först sätt för att hitta en numerisk modell som kan reproducera effekten av plasma utan att öka beräkningskostnad. Plasmaaktuatorn  modelleras i detta arbete genom att ett källterm adderas till Navier-Stokes ekvationer. För att bestämma styrkan och den rumsliga utbredningen hos källtermen, utförs en optimering för att minimera skillnaden mellan experimentella och simulerade profiler av plasma inducerad strömningshastighet. 

    Plasmaaktuatormodellen används därefter i Large Eddy Simulations (LES) för att beräkna strömningen kring en halvcylinder med Reynolds tal Re=65*10^3 och Re=32*10^3. Två typer av fall studeras. I det första fallet används en enda aktuator. I det andra fallet, är ett par på varandra följande aktuatorer placerade, där aktuatorernas position på halvcylinder ändras. Resultaten visar att en luftmotståndsminskning på upp till 10% kan erhållas. Den idealiska platsen för aktuatorn bedöms vara nära den punkt där strömningen utan aktuator separerar.

    Slutligen undersöks Dynamic Mode Decomposition (DMD) som ett verktyg för att extrahera koherenta dynamiska strukturer i en turbulent strömning. DMD används först för att analysera pulserande kanalströmning där pulsationen har en känd frekvens. Resultaten visar att DMD ger liknande resultat som då fas-medelvärdesbildning görs vid oscillationsfrekvensen. Förekomsten av turbulens buller hindrar dock möjligheten att identifiera moder vid högre övertoner. DMD används också för att analysera strömningen kring halv-cylindern. I avhandlingen visas att spektrat i vaken är bredbandigt men att även moder inom distinkta frekvensintervall fanns vara belägna i avgränsade områden i vaken.

  • Pöppel, Ludmila
    Stockholms universitet, Humanistiska fakulteten, Institutionen för slaviska och baltiska språk, finska, nederländska och tyska, Slaviska språk.
    Pöppel, Ludmila
    Stockholms universitet, Humanistiska fakulteten, Institutionen för slaviska och baltiska språk, finska, nederländska och tyska, Slaviska språk.
    Беспорядки (disturbances) vs.волнения (unrest): towards the delimitation of synonyms2016Ingår i: Да веселитсѧ Новъградъ Må Novgorod fröjda sig: Hyllningsskrift till Elisabeth Löfstrand / [ed] Per Ambrosiani, Per-Arne Bodin och Nadezjda Zorikhina Nilsson, Stockholm: Acta Universitatis Stockholmiensis, 2016, 167-178 s.Kapitel i bok, del av antologi (Refereegranskat)
    Abstract [en]

    The purpose of this paper is to analyze the combinability of thenear-synonyms беспорядки (disturbances) and волнения (unrest). Their combinatorial properties are investigated using extensive corpus data –Sketch Engine and the Russian National Corpus (RNC). Investigating combinatorial features through the use of text corpora can help identify semantic differences that are not intuitively obvious. I will demonstrate how combinatorial properties were discovered, since analysis of these materials has revealed a number of combinatorial preferences. In future studies my findings will serve as the basis for identifying semantic and pragmatic distinctions between these near-synonyms.

  • Bruhn, Jørgen
    et al.
    Linnéuniversitetet, Fakulteten för konst och humaniora (FKH), Institutionen för film och litteratur (IFL).
    Bruhn, Jørgen
    Linnéuniversitetet, Fakulteten för konst och humaniora (FKH), Institutionen för film och litteratur (IFL).
    Lutas, Liviu
    Linnéuniversitetet, Fakulteten för konst och humaniora (FKH), Institutionen för språk (SPR).
    Intermedialitet och litteraturanalys: Del 4 i Läslyftsmodulen Perspektiv på litteraturundervisning, gymnasieskola2016Övrigt (Övrig (populärvetenskap, debatt, mm))
    Abstract [sv]

    Syftet med denna text är att presentera en metod för analys ac skönlitterära texter i gymnasieskolan, inom Skolverkets satsning på Läslyftet. Denna metod, kallad intermedial analys, tar sin utgångspunkt i hur olika medier blir synliga i skönlitteraturen. Intermediala analyser har en hel del gemensamt med intertextuella analyser, det vill säga relationer mellan olika texter, men den intermediala kan vara enklare för eleverna att ta till sig.

  • Widerström, Micael
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
    Widerström, Micael
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
    Wiström, Johan
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Infektionssjukdomar.
    Edebro, Helén
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
    Marklund, Elisabeth
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
    Backman, Mattias
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
    Lindqvist, Per
    Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.
    Monsen, Tor
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi.
    Colonization of patients, healthcare workers, and the environment with healthcare-associated Staphylococcus epidermidis genotypes in an intensive care unit: a prospective observational cohort study2016Ingår i: BMC Infectious Diseases, ISSN 1471-2334, E-ISSN 1471-2334, Vol. 16, 743Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: During the last decades, healthcare-associated genotypes of methicillin-resistant Staphylococcus epidermidis (HA-MRSE) have been established as important opportunistic pathogens. However, data on potential reservoirs on HA-MRSE is limited. The aim of the present study was to investigate the dynamics and to which extent HA-MRSE genotypes colonize patients, healthcare workers (HCWs) and the environment in an intensive care unit (ICU).

    Methods: Over 12 months in 2006-2007, swab samples were obtained from patients admitted directly from the community to the ICU and patients transferred from a referral hospital, as well as from HCWs, and the ICU environment. Patients were sampled every third day during hospitalization. Antibiotic susceptibility testing was performed according to EUCAST guidelines. Pulsed-field gel electrophoresis and multilocus sequence typing were used to determine the genetic relatedness of a subset of MRSE isolates.

    Results: We identified 620 MRSE isolates from 570 cultures obtained from 37 HCWs, 14 patients, and 14 environmental surfaces in the ICU. HA-MRSE genotypes were identified at admission in only one of the nine patients admitted directly from the community, of which the majority subsequently were colonized by HA-MRSE genotypes within 3 days during hospitalization. Almost all (89%) of HCWs were nasal carriers of HA-MRSE genotypes. Similarly, a significant proportion of patients transferred from the referral hospital and fomites in the ICU were widely colonized with HA-MRSE genotypes.

    Conclusions: Patients transferred from a referral hospital, HCWs, and the hospital environment serve as important reservoirs for HA-MRSE. These observations highlight the need for implementation of effective infection prevention and control measures aiming at reducing HA-MRSE transmission in the healthcare setting.

  • Ågren, Helena
    et al.
    Jönköpings kommun.
    Ågren, Helena
    Jönköpings kommun.
    Alfredsson, Marie
    Jönköpings kommun.
    Ernsth-Bravell, Marie
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping).
    Westling, Hanna
    Jönköpings kommun.
    Rambeslut2016Ingår i: 10 förbättringar från DIALOGEN: En långsiktig strategi för att utveckla en innovativ, sammanhållen och hållbar socialtjänst / [ed] Stefan Österström, Jönköping: Jönköpings kommun, socialtjänsten , 2016, 41-59 s.Kapitel i bok, del av antologi (Övrigt vetenskapligt)
    Abstract [sv]

    I samverkan mellan Jönköpings kommun och Institutet för gerontologi, Hälsohögskolan i Jönköping, genomfördes en intervjustudie parallellt med införandet av rambeslut under hösten 2015. Att respektera individens rätt till självbestämmande och inflytande är grundläggande värden och förhåll-ningssätt i svensk äldreomsorg. Rambeslut i hemtjänsten är ett salutogent arbetssätt som syftar till att i högre utsträckning stärka individens möjlighet till självbestämmande och att utöva inflytande över insatsernas utformning avseende hur och när de ska utföras. Den här studien gav viktig kunskap kring äldre personers uppfattning av begrepp som inflytande och självbestämmande och vad hemtjänsten bör fokusera på för att de äldre ska ha ett reellt inflytande och självbestämmande. Resultaten används till att utveckla äldre personers möjlighet till inflytande och självbestämmande.

  • Waern, Margda
    et al.
    Waern, Margda
    Kaiser, Niclas
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Psykiatri.
    Salander Renberg, Ellinor
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Psykiatri.
    Psychiatrists' experiences of suicide assessment2016Ingår i: BMC Psychiatry, ISSN 1471-244X, E-ISSN 1471-244X, Vol. 16, 440Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Clinical guidelines for suicide prevention often stress the identification of risk and protective factors as well as the evaluation of suicidal intent. However, we know very little about what psychiatrists actually do when they make these assessments. The aim was to investigate psychiatrists' own accounts of suicide assessment consultations, with a focus on their behaviors, attitudes and emotions.

    Method: Semi-structured in depth interviews were carried out with a purposive selection of 15 psychiatrists.

    Results: Thematic analysis revealed three main themes: understanding the patient in a precarious situation, understanding one's own reactions, and understanding how the doctor-patient relationship impacted on risk assessment and management decisions. Emotional contact and credibility issues were common subthemes that arose when the respondents talked about trying to understand the patient. The psychiatrists stressed the semi-intuitive nature of their assessments. Problems related to the use of risk factor assessments and rating scales were apparent. Assessment consultations could evoke physical and emotional symptoms of anxiety, and concerns about responsibility could lead to repressive management decisions. In situations of mutual trust, however, the assessment consultation could kick-start a therapeutic process.

    Conclusion: This study highlights psychiatrists' experiences in clinical suicide assessment situations. Findings have implications for professional development as well as for service delivery.

  • Boström, Martina
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping).
    Boström, Martina
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping).
    Ekberg, Kristina
    Enheten för projektledning och verksamhetsutveckling i Jönköpings Kommun.
    Ernsth-Bravell, Marie
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping).
    Ågren, Helena
    Jönköpings kommun.
    Stärka tryggheten i flytt till särskilt boende2016Ingår i: 10 förbättringar från DIALOGEN: En långsiktig strategi för att utveckla en innovativ, sammanhållen och hållbar socialtjänst / [ed] Stefan Österström, Jönköping: Jönköpings kommun, socialtjänsten , 2016, 133-150 s.Kapitel i bok, del av antologi (Övrigt vetenskapligt)
    Abstract [sv]

    De flesta kan kanske känna igen sig i en situation då flytt till särskilt boende blir aktuellt, oavsett om det gäller en nära anhörigs flytt eller sin egen. Våra skäl och orsaker till flytten kan variera men behovet av vård och omsorg är ofta detsamma. I en tid av livet då skörheten gör sig påmind och behovet av hjälp och stöd ökar, kan flytten bli ett känslosamt möte mellan det förflutna och en oviss framtid. Att arbeta för att få den äldre personen att känna trygghet under hela flyttprocessen och även under den första tiden på det särskilda boendet blir därför viktigt. Socialtjänsten och Hälsohögskolan har sedan 2013 genomfört ett samverkansprojekt i syfte att fördjupa kunskapen om äldres upplevelse av trygghet i flyttprocessen, för att på så vis förbättra och stärka den.

  • Sarneel, Judith M.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och geovetenskap. Ecology and Biodiversity Group and Plant Ecophysiology Group, Utrecht University, Utrecht, The Netherlands.
    Sarneel, Judith M.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och geovetenskap. Ecology and Biodiversity Group and Plant Ecophysiology Group, Utrecht University, Utrecht, The Netherlands.
    Effects of experimental snowmelt and rain on dispersal of six plant species2016Ingår i: Ecohydrology, ISSN 1936-0584, E-ISSN 1936-0592, Vol. 9, nr 8, 1464-1470 s.Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Water flows affect dispersal of propagules of many plant species, and rivers and streams are therefore very important dispersal vectors. However, small water flows such as trough rain and snowmelt are much more common, but their effects on dispersal are barely studied. The importance of this form of dispersal deserves attention, especially when considering that climate change is predicted to change the amounts of rain and snow worldwide. Dispersal through melting snow and rain was addressed experimentally, using artificial soils mounted on slopes with different angles and subjected to a melting snow pack or an equivalent amount of dripping water. Seeds on the soil moved on average 3.02 cm (+/- 1.81 SE) in rain treatments and 0.23 cm (+/- 0.3 SE) in snowmelt treatments. Tracking plastic granules in field conditions further showed that snowmelt exhibited minimal dispersal capacity. Dispersal distances by rain were enhanced by increasing slope angles and with decreasing seed volume. Given that many species in cold environments have small seeds, dispersal by rain could provide an important (secondary) dispersal mechanism in these habitats.

  • Löflund, Emma-Lina
    Stockholms universitet, Humanistiska fakulteten, Institutionen för slaviska och baltiska språk, finska, nederländska och tyska, Slaviska språk.
    Löflund, Emma-Lina
    Stockholms universitet, Humanistiska fakulteten, Institutionen för slaviska och baltiska språk, finska, nederländska och tyska, Slaviska språk.
    Marianna S. Landa: Maximilian Voloshin’s Poetic Legacy and the Post-Soviet Russian Identity. Basingstoke, Hampshire 2015: Palgrave Macmillian2016Ingår i: Slovo: Journal of Slavic Languages, Literatures and Cultures , ISSN 2001-7395, Vol. 57, 78-85 s.Artikel, recension (Refereegranskat)
  • Hultqvist, Sara
    et al.
    Ph.D, lektor, Socialhögskolan, Lunds universitet.
    Hultqvist, Sara
    Ph.D, lektor, Socialhögskolan, Lunds universitet.
    Nørup,, Iben
    Post doc, Ph.D., Institut for Sociologi og Socialt Arbejde, Aalborg Universitet.
    Sjukskrivning och genus i Norden: Vad vi vet och vad vi inte vet2016Artikel, forskningsöversikt (Övrig (populärvetenskap, debatt, mm))
    Abstract [sv]

    Nordens välfärdscenter projekt Sjukskrivning och genus i Norden - vad vi vet och vad vi inte vet ärett uppdrag från Nordiska ministerrådet för social- och hälsopolitik. Projektets huvudsakliga syfteär att göra en nordisk forskningssammanställning om den psykiska hälsan utifrån ett genusperspektiv.

    Könsskillnader i sjukfrånvaron förekommer, om än i varierande grad, i samtliga nordiska länder.Avsikten med forskningsgenomgången är att få till stånd en bättre jämförande översikt över politikenpå området. Detta kan underlätta erfarenhetsutbyte om effekter av politik samt främjaytterligare samarbete på området. Det är vår förhoppning att rapporten ska bidra till en ökadkunskap om sambanden mellan psykisk ohälsa, arbetsliv och sjukfrånvaro i Norden och i vad månförekomsten av skillnader i sjukskrivningar på grund av psykisk ohälsa skiljer sig åt mellan ländernasamt huruvida det finns könsskillnader som i detta avseende bör beaktas.

    Vi hoppas att kartläggningen kan leda till fördjupade nordiska studier och insatser, både på gemensamnordisk nivå och i respektive land.

  • Disputation: 2017-02-10 10:15 Häggsalen, Uppsala
    Yang, Wenxing
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi.
    Yang, Wenxing
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi.
    Exploring Electronic Processes at the Mesoporous TiO2/Dye/Electrolyte Interface2017Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Dye sensitized solar cells (DSSCs) are an attractive way to convert light into electricity. Its development requires a detailed understanding and kinetic optimization of various electronic processes, especially those occurring at the mesoporous TiO2/dye/electrolyte interface. This dissertation work is focused on the exploration of the various electronic processes at the sensitized-electrode/electrolyte interface by using various electrochemical and photochemical methods.

    Firstly, an alternative redox couple—TEMPO/TEMPO·+ with a relatively high positive redox potential—is explored, aiming to reduce the energy loss during the dye regeneration process. Despite the fast dye regeneration, the charge recombination between the electrons in the conduction band of mesoporous TiO2 and the oxidized redox species is found to be the limiting factor of the device. Further, a more efficient tandem-electrolyte system is developed, leading to DSSCs with the power conversion efficiency of 10.5 % and 11.7 % at 1 sun and 0.5-sun illumination, respectively. An electron-transfer cascade process during dye regeneration by the redox mediators is discovered to be beneficial. Further stability studies on the device suggest the crucial role of TiO2/dye/electrolyte interfaces in the long-term stability of cobalt bipyridyl electrolyte-based DSSCs.

    On the fundamental level, the local electric field and Stark effects at the TiO2/dye/electrolyte interface are investigated in various aspects—including the charge compensation mechanism, the factors affecting the electric field strength, as well as its impact on charge transfer kinetics. These results give further insights about the TiO2/dye/electrolyte interface, and contribute to the further development and understanding of DSSCs.

  • Öhman, Anna
    Karlstads universitet, Fakulteten för humaniora och samhällsvetenskap (from 2013).
    Öhman, Anna
    Karlstads universitet, Fakulteten för humaniora och samhällsvetenskap (from 2013).
    Kameraanvändning i videoobservation2016Ingår i: Kapet (elektronisk), E-ISSN 2002-3979, Vol. 12, nr 2, 75-85 s.Artikel i tidskrift (Övrigt vetenskapligt)
  • Gunnarsson, Carina
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, JTI Institutet för Jordbruks- och Miljöteknik.
    Gunnarsson, Carina
    RISE, SP – Sveriges Tekniska Forskningsinstitut, JTI Institutet för Jordbruks- och Miljöteknik.
    Anerud, Erik
    Jonsson, Nils
    RISE, SP – Sveriges Tekniska Forskningsinstitut, JTI Institutet för Jordbruks- och Miljöteknik.
    Iwarsson Wide, Maria
    Segerborg Fick, Anna
    RISE, SP – Sveriges Tekniska Forskningsinstitut, JTI Institutet för Jordbruks- och Miljöteknik.
    Optimerad lagring av biomassa: en strategisk innovationsagenda2016Rapport (Övrigt vetenskapligt)
    Abstract [sv]

    I dag finns stor kunskap inom området lagring av biomassa, även om kunskapen i delar är fragmenterad. Inom energiområdet finns problem med både lagringsförluster och arbetsmiljö. Vid lagring av grödor till foder och livsmedel är bibehållen kvalitet hos biomassan under lagring en förutsättning, och mycket forskning och utveckling har bedrivits inom detta område. Genom samverkan mellan olika områden skapar vi förutsättningar att tänka i nya banor och öka möjligheterna för en optimerad lagring av biomassa. Arbetet med agendan har gett nya gränsöverskridande diskussioner och samarbeten. Med en förväntad kraftigt ökad efterfrågan och därmed konkurrens om biomassa blir effektivitet och hållbarhet nyckelfaktorer för fortsatt god tillgång. Kontinuerliga förbättringar i alla led av tillförselkedjan är nödvändiga för att hantera dessa i grunden positiva marknadsförändringar. Ett billigare och mer homogent bio-bränsle från jord- och skogsbruk leder till ökad konkurrenskraft gentemot andra idag billigare bränslen. Vid biobaserad värme- och kraftvärmeproduktion står bränslet för en av de största kostnadsposterna, vilket gör hantering och lagring med låga förluster högt prioriterat. Biobränslen från jord- och skogsbruk har en hög fukthalt vid skörd, vilket innebär att de har låg lagringsstabilitet. För att få ned kostnaderna för hantering och lagring, och kunna leverera efterfrågade kvaliteter och därmed öka bio-bränslenas konkurrenskraft, behövs mer kunskap om vad som händer med bränslet under olika lagringsförhållanden med olika lagrings- och hanteringsmetoder. Grundläggande och fördjupade kunskaper för att bedöma lagringsstabiliten för biomassa, framför allt livsmedelsbaserade såsom spannmål och rapsfrö, finns och är helt nödvändig för att garantera livsmedelssäkerhet. Dessa erfarenheter kan användas för att öka kunskapen om lagringsstabilitet och lagringsförluster hos biomassa som helhet. Denna agenda har tagits fram i samverkan mellan forskare från jord- och skogsbruk samt representanter från råvaruproducenter och energibolag som slutanvändare. Agendans syfte är att skapa ett bra utgångs-läge för en effektivare hantering av biomassa genom kunskapsöverföring mellan branscher. Agendans mål är ta fram forskningsbehov för utveckling och innovationer inom området som ska leda till effektiv och kvalitetssäkrad hantering av biomassa. Fokus är användning av biomassa inom energisektorn. Agendan avgränsas till att omfatta primära och sekundära oförädlade biobränslen från skogsbruk och jordbruk samt återvunna trädbränslen för värme- och kraftvärmeproduktion för anläggningar större än 1 MW. Vår vision är att använda biobränslets fulla potential genom kontrollerad lagring med låga förluster som ger effektiva och lönsamma leveranser med förutsägbar och homogen kvalitet utan hälsorisker. Vid två workshops på JTI i Uppsala träffades deltagarna för att identifiera kunskapsluckor, forskningsbehov och aktiviteter. För att inkludera synpunkter från fler aktörer genomfördes telefonintervjuer med ytterligare personer med koppling till biomassalagring.

  • Stuer-Lauridsen, Frank
    et al.
    Stuer-Lauridsen, Frank
    Sanderbo, Jesper
    IMOs ballastvandskonvention i nordiske småsamfund: – resultater fra en nordisk workshop2017Rapport (Övrigt vetenskapligt)
    Abstract [da]

    I juni 2016 afholdte Nordisk Ministerråds Småsamfundsgruppe under arbeidsgruppen för baerdedyktig konsumtion og produktion en workshop om implementering af IMOs ballastvandskonvention i nordiske småsamfund. Workshoppen fandt sted i København, og blev arrangeret i samarbejde med LITEHAUZ.

    Denne rapport er et samlet workshop- og projektdokument som indeholder information om selve workshoppens program og indhold, præsentationer, korte referater af workshopdeltagernes gruppearbejde og opsummeringer med fokus på de forvaltningsmæssige udfordringer og løsninger, som workshoppen er nået frem til.

  • Engelhardt, Ilka. A. D.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Rymd- och plasmafysik. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutet för rymdfysik, Uppsalaavdelningen.
    Engelhardt, Ilka. A. D.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Rymd- och plasmafysik. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutet för rymdfysik, Uppsalaavdelningen.
    Plasma and Dust at Saturn's Icy Moon Enceladus and Comet 67P/Churyumov-Gerasimenko2016Licentiatavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Saturn’s moon Enceladus and comet 67P/Churyumov-Gerasimenko both are examples of icy solar system objects from which gas and dust flow into space. At both bodies, the gas becomes partly ionized and the dust grains get charged. Both bodies have been visited by spacecraft carrying similar Langmuir probe instruments for observing the plasma and the charged dust. The conditions at Enceladus and the comet turn out to be different, so we emphasize different aspects of their plasma environments. At Enceladus, we concentrate on the characteristic plasma regions and charged dust. At the comet, we investigate cold electrons.

    At Enceladus, internal frictional heating leads to gas escaping from cracks in the ice in the south pole region. This causes a plume of gas, which becomes partially ionized, and dust, becoming charged. We have investigated the plasma and charged nanodust in this region by the use of the Langmuir Probe (LP) of the Radio and Plasma Wave Science (RPWS) instrument on Cassini. The dust charge density can be calculated from the quasineutrality condition, the difference between ion and electron density measurements from LP. We found support for this method by comparing to measurements of larger dust grains by the RPWS electric antennas. We use the LP method to find that the plasma and dust environment of Enceladus can be divided into at least three regions. In addition to the well known plume, these are the plume edge and the trail region.

    At the comet, heat from the Sun sublimates ice to gas dragging dust along as it flows out into space. When gas molecules are hit by ionizing radiation we get a plasma. Models predict that the electron temperature just after ionization is around 10 eV, but that this collisions with the neutral gas should cool the electrons to below 0.1 eV. The Langmuir Probe instrument LAP has previously been used to show that the warm component exists at the comet. We present the first measurements of the cold component, co-existing with the warm component. We find that that the cold plasma often is observed as brief pulses in the LAP data, which we interpret as filamentation of the cold plasma.

  • Ergül, Adem Björn
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Funktionella material, FNM. Jet Propulsion Laboratory, Caltech.
    Ergül, Adem Björn
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Funktionella material, FNM. Jet Propulsion Laboratory, Caltech.
    Magnesium Diboride (MgB2) & Molybdenum Silicide (MoSi) Superconducting Nanowires2016Bok (Övrigt vetenskapligt)
  • Bylin, Maria
    Stockholms universitet, Humanistiska fakulteten, Institutionen för svenska och flerspråkighet, Svenska/Nordiska språk.
    Bylin, Maria
    Stockholms universitet, Humanistiska fakulteten, Institutionen för svenska och flerspråkighet, Svenska/Nordiska språk.
    Adjektivböjningens -a och -e.: Ett seglivat variationstillstånd.2016Ingår i: Språk & Stil, ISSN 1101-1165, Vol. 26, 69-100 s.Artikel i tidskrift (Refereegranskat)
    Abstract [sv]

    The adjectival agreement of noun phrases referring to human individuals in Swedish is renowned for its complex pattern of variation between -a and -e. This article reports three studies on the subject.The first one maps the use of the marked form -e, and finds it to be mainly used for males and generic individuals, but occasionally also for other animates, such as animals, women, and nonpersonal agents. The variation between -a and -e for males has often been thought of as regionally governed, but the second study, based on blog texts, suggests that region plays a subordinate role(or possibly no role at all) in writing. Many factors have been said to influence the variation, and the third study reported in the article tests their impact with statistical methods on modern data. Theresults indicate that the variation in noun phrases referring to specific male individuals is more influenced by pragmatic and semantic factors, as compared to the variation in noun phrases referring to generic individuals, which is more affected by formal and lexical factors. This difference is interpretedas a consequence of how the referents are conceptualized.The variation between -e and -a is often assumed to reveal an ongoing change. However, when theresults of these studies are compared to a thorough description of the system from 1892, the emerging picture is one of enduring variation, influenced by the very same factors today as over a century ago.

  • Olsson, Jan
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi.
    Olsson, Jan
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi.
    Lövheim, Hugo
    Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Geriatrik.
    Honkala, Emma
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi.
    Karhunen, Pekka J.
    Elgh, Fredrik
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi.
    Kok, Eloise H.
    HSV presence in brains of individuals without dementia: the TASTY brain series2016Ingår i: Disease Models and Mechanisms, ISSN 1754-8403, E-ISSN 1754-8411, Vol. 9, nr 11, 1349-1355 s.Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2 in the Tampere Autopsy Study (TASTY) brain samples using PCR and sero-positivity in plasma, and associations with Alzheimer's disease neuropathology. HSV was shown to be present in human brain tissue in 11/584 (1.9%) of samples in the TASTY cohort, of which six had Alzheimer's disease neuropathological amyloid beta (A beta) aggregations. Additionally, serological data revealed 86% of serum samples tested were IgG-positive for HSV. In conclusion, we report epidemiological evidence of the presence of HSV in brain tissue free from encephalitis symptoms in a cohort most closely representing the general population (a minimum prevalence of 1.9%). Whereas 6/11 samples with HSV DNA in the brain tissue had A beta aggregations, most of those with A beta aggregations did not have HSV present in the brain tissue.

  • Ström, Per
    Uppsala universitet, Universitetsförvaltningen.
    Ström, PerUppsala universitet, Universitetsförvaltningen.
    Promotionsfesten i Uppsala den 27 januari 20172017Samlingsverk (redaktörskap) (Övrig (populärvetenskap, debatt, mm))
  • Haglund, Axel
    et al.
    Haglund, Axel
    Lindh, Asa U.
    Lysell, Henrik
    Renberg, Ellinor Salander
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap.
    Jokinen, Jussi
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap. Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
    Waern, Margda
    Runeson, Bo
    Interpersonal violence and the prediction of short-term risk of repeat suicide attempt2016Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, 36892Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this multi-center cohort study, suicide attempters presenting to hospital (N = 355, 63% women) were interviewed using the Karolinska Interpersonal Violence Scale (KIVS) and followed-up by medical record review. Main outcome was non-fatal or fatal repeat suicide attempt within six months. Also, repeat attempt using a violent method was used as an additional outcome in separate analyses. Data were analyzed for the total group and for men and women separately. Repeat attempts were observed within six months in 78 persons (22%) and 21 (6%) of these used a violent method. KIVS total score of 6 or more was associated with repeat suicide attempt within six months (OR = 1.81, CI 1.08-3.02) and predicted new attempts with a sensitivity of 62% and a specificity of 53%. A three-fold increase in odds ratio was observed for repeat attempt using a violent method (OR = 3.40, CI 1.22-9.49). An association between exposure to violence in adulthood and violent reattempt was seen in women (OR = 1.38, CI 1.06-1.82). The overall conclusions are that information about interpersonal violence may help predict short-term risk for repeat suicide attempt, and that structured assessment of interpersonal violence may be of value in risk assessment after attempted suicide.

  • Monteferrante, C. G.
    et al.
    Monteferrante, C. G.
    Jirgensons, A.
    Varik, Vallo
    Umeå universitet, Medicinska fakulteten, Molekylär Infektionsmedicin, Sverige (MIMS). Institute of Technology, University of Tartu, Nooruse 1, 50411 Tartu, Estonia.
    Hauryliuk, VVasili
    Umeå universitet, Medicinska fakulteten, Molekylär Infektionsmedicin, Sverige (MIMS). Institute of Technology, University of Tartu, Nooruse 1, 50411 Tartu, Estonia.
    Goessens, W. H. F.
    Hays, J. P.
    Evaluation of the characteristics of leucyl-tRNA synthetase (LeuRS) inhibitor AN3365 in combination with different antibiotic classes2016Ingår i: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 35, nr 11, 1857-1864 s.Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Aminoacyl tRNA synthetases are enzymes involved in the key process of coupling an amino acid to its cognate tRNA. AN3365 is a novel antibiotic that specifically targets leucyl-tRNA synthetase, whose development was halted after evaluation in phase II clinical trials owing to the rapid selection of resistance. In an attempt to bring AN3365 back into the developmental pipeline we have evaluated the efficacy of AN3365 in combination with different classes of antibiotic and characterized its mechanism of action. Although we detect no synergy or antagonism in combination with a range of antibiotic classes, a combination of AN3365 with colistin reduces the accumulation of AN3365-resistant and colistin resistance mutations. We also demonstrate that treatment with AN3365 results in the dramatic accumulation of the alarmone (p)ppGpp, the effector of the stringent response-a key player in antibiotic tolerance.

  • Peters, Björn
    et al.
    Statens väg- och transportforskningsinstitut, Trafik och trafikant,TRAF, Körsimulering och visualisering, SIM.
    Peters, Björn
    Statens väg- och transportforskningsinstitut, Trafik och trafikant,TRAF, Körsimulering och visualisering, SIM.
    Selander, Helena
    Mobilitetscenter.
    Stave, Christina
    Statens väg- och transportforskningsinstitut, Trafik och trafikant,TRAF, Förare och fordon, FOF.
    Andersson Hultgren, Jonas
    Statens väg- och transportforskningsinstitut, Trafik och trafikant,TRAF, Körsimulering och visualisering, SIM.
    Jansson, Andreas
    Statens väg- och transportforskningsinstitut, Trafik och trafikant,TRAF, Körsimulering och visualisering, SIM.
    Evaluation of driving simulator based training for older drivers in Sweden: Deliverable 2.4.32016Rapport (Övrigt vetenskapligt)
    Abstract [sv]

    Förmågan att kunna bedöma sin körförmåga korrekt kan vara avgörande för en säker mobilitet på äldre dagar. Överskattning kan leda till en ökad risk och underskattning kan leda till obefogade mobilitetsinskränkningar. En före/efter interventionsstudie genomfördes med syfte att förbättra äldre bilförares förmåga att bedöma sin egen körförmåga. Syftet var inte att förbättra körförmågan i sig utan förmågan att bedöma sig själv, det vill säga att bli bättre kalibrerad. Således utvecklades och utvärderades ett simulatorbaserat träningsprogram med en grupp på 36 äldre förare. Simulatorsjuka (illamående), gjorde dock att endast 21 förare kunde genomföra studien i sin helhet. Deltagarna fick vid upprepade tillfällen bedöma sin körförmåga genom att svara på frågan ”Hur bra tycker du att du körde? (1 = mycket dåligt till 5 = mycket bra). En erfaren arbetsterapeut (specialiserad i att bedöma körförmåga) gjorde expertbedömningar av körningarna med samma skala som en referens på korrekt bedömd körförmåga.

    Återkoppling kan vara ett effektivt verktyg för förändring, detta verktyg ville vi utvärdera i vår studie. Således, fick deltagarna återkoppling i form av en lista på vilka fel de hade gjort efter varje övning (t.ex. glömde använda körriktningsvisare, körde för fort). Återkoppling kunde också ges som information om vad som var rätt (t.ex. lämnade företräde till fotgängare, höll rätt hastighet). Således delades gruppen i två grupper en (n=11) som bara fick veta vilka fel de hade gjort och en (n=10) som även fick veta vad de hade gjort rätt. Träningen genomfördes vid tre olika tillfällen.

  • Zillén, Kavot
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Juridiska fakulteten, Juridiska institutionen.
    Zillén, Kavot
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Juridiska fakulteten, Juridiska institutionen.
    Garland, Jameson
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Juridiska fakulteten, Juridiska institutionen.
    Slokenberga, Santa
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Juridiska fakulteten, Juridiska institutionen.
    The Rights of Children in Biomedicine: Challenges posed by scientific advances and uncertainties2016Rapport (Övrigt vetenskapligt)
    Abstract [en]

    The Committee on Bioethics of the Council of Europe commissioned this study to identify potential areas of heightened concern for the rights of children that may be unfavorably affected by scientific advances and uncertainties in biomedicine. This report is the result of that study. It provides substantive illustrations of the diversity of problems generated by biomedical developments, including the expanded use of certain biomedical procedures, emerging technologies, and innovative therapies. It also addresses uncertain risks to children through the continuation of longstanding biomedical practices that lack sufficient scientific support. Because considerable legal protections have been developed for biomedical research and continue to be debated in great depth, this report focuses more broadly on biomedicine as a whole. The specific concern addressed here is not about the research process and regulation as such, but rather on how scientific advances and risk-laden practices reach children in biomedicine – whether through health care practices or in other biomedical settings. Mapping out the areas of concern for this report required not only identifying the technological advances and scientific challenges at stake but contemplating these challenges first and foremost from the perspective of the rights of children as class – formally collectively defined as persons from birth to age 18, unless they have attained majority status. Because a subsequent report will analyze the potential legal frameworks protecting children from the scientific risks and uncertainties identified here, this report identifies the challenges in protecting children relative to those rights that are commonly described in international human rights discourse, with only summary references to specific legal instruments in the report’s conclusions. The aim of the report is to demonstrate how the scientific risks and uncertainties illustrated here may affect the rights of children from birth through adolescence, in a variety of ways. Chapter 2 surveys differences in childhood development to illustrate why the lack of protection from scientific risks and uncertainty persists, in part because of limited understanding of the developmental differences and vulnerabilities of children at different phases of life. The report then expands on how many interventions may reach children at the earliest stages of their development, such as through assisted reproduction and other interventions in utero (Chapter 3) as well as in the field of genetics (Chapter 4). The report then addresses children who have been subjected to high-risk and controversial clinical practices, many of which lack sufficient scientific support regarding their safety. Among those children at risk are sexual or gender minority children (Chapter 5) and children diagnosed with serious physical and mental health needs (Chapter 6). The next chapters address two areas affecting critically ill children where considerable policy debate has taken place, but without sufficient regard to scientific advances and uncertainties, specifically in transplantation (Chapter 7) and end-of-life decisions (Chapter 8). In the final chapter, the report sets forth numerous rights of children in biomedicine that are currently at stake from scientific advances and uncertainties – not only the right to the highest attainable standard of health but rights protecting their physical and psychological integrity and their privacy and identity, as well as freedom from discrimination. The landscape of these rights is as vast and potentially complex as biomedicine. The report thus concludes that the biomedical controversies surveyed here signal a need for systemic, continuous and multidisciplinary oversight of these issues, as well as for many biomedical interventions that could not be covered here in depth. These matters cannot be left to biomedical expertise alone, but instead require vigilant oversight from human rights authorities and scholars with an understanding of these issues.

  • Habibipour, Abdolrasoul
    et al.
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Datavetenskap.
    Habibipour, Abdolrasoul
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Datavetenskap.
    Bergvall-Kåreborn, Birgitta
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Datavetenskap.
    Towards a User Engagement Process Model in Open Innovation2016Ingår i: The ISPIM Innovation Summit, Kuala Lumpur, Malaysia on 4-7 December 2016, 2016Konferensbidrag (Refereegranskat)
    Abstract [en]

    Studies on open innovation have increasingly emphasized the role of individual users as collaborators in the innovation processes. Keeping users enthusiastically engaged throughout the information systems development (ISD) process for open innovation approaches is of crucial importance, specifically when the participation is voluntary. Although a few studies exist that have presented process models for user engagement, none of them are specifically based on the voluntary contribution of the users in an open environment, nor included the detailed attributes of the phenomenon of user drop-outs in their presented models. By combining the results of a comprehensive literature review and a qualitative case study of user engagement, this study aims to develop a user engagement process model that includes the variety of reasons for user drop-out, and then to present some practical guidelines that would facilitate prolonged user engagement in the ISD process in an open innovation environment.

  • Karlsson, Terese
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Karlsson, Terese
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Lundholm, Marie
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Widmark, Anders
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Persson, Emma
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Tumor Cell-Derived Exosomes from the Prostate Cancer Cell Line TRAMP-C1 Impair Osteoclast Formation and Differentiation2016Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, nr 11, e0166284Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Skeletal metastatic disease is a deleterious consequence of dissemination of tumor cells from numerous primary sites, such as prostate, lung and breast. Skeletal metastases are still incurable, resulting in development of clinical complications and decreased survival for cancer patients with metastatic disease. During the last decade, tumor cell-derived microvesicles have been identified and suggested to be involved in cancer disease progression. Whether cancer exosomes are involved in tumor and bone cell interactions in the metastatic site is still, however, a rather unexplored field. Here we show that exosomes isolated from the murine prostate cancer cell line TRAMP-C1 dramatically decrease fusion and differentiation of monocytic osteoclast precursors to mature, multinucleated osteoclasts. The presence of tumor cell-derived exosomes also clearly decreased the expression of established markers for osteoclast fusion and differentiation, including DC-STAMP, TRAP, cathepsin K, and MMP-9. In contrast, exosomes derived from murine fibroblastic cells did not affect osteoclast formation. Our findings suggest that exosomes released from tumor cells in the tumor-bone interface are involved in pathological regulation of bone cell formation in the metastatic site. This further strengthens the role of tumor cell-derived microvesicles in cancer progression and disease aggressiveness.

  • Allas, Ular
    et al.
    Allas, Ular
    Toom, Lauri
    Selyutina, Anastasia
    Maeorg, Uno
    Medina, Ricardo
    Merits, Andres
    Rinken, Ago
    Hauryliuk, Vasili
    Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten). Umeå universitet, Medicinska fakulteten, Molekylär Infektionsmedicin, Sverige (MIMS). University of Tartu, Institute of Technology, Nooruse 1, Tartu 50411, Estonia.
    Kaldalu, Niilo
    Tenson, Tanel
    Antibacterial activity of the nitrovinylfuran G1 (Furvina) and its conversion products2016Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, 36844Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    2-Bromo-5-(2-bromo-2-nitrovinyl) furan (G1 or Furvina) is an antimicrobial with a direct reactivity against thiol groups. It is active against Gram-positive and Gram-negative bacteria, yeasts and filamentous fungi. By reacting with thiol groups it causes direct damage to proteins but, as a result, is very short-living and interconverts into an array of reaction products. Our aim was to characterize thiol reactivity of G1 and its conversion products and establish how much of antimicrobial and cytotoxic effects are due to the primary activity of G1 and how much can be attributed to its reaction products. Stability of G1 in growth media as well as its conversion in the presence of thiols was characterized. The structures of G1 decomposition products were determined using NMR and mass-spectroscopy. Concentration-and time-dependent killing curves showed that G1 is bacteriostatic for Escherichia coli at the concentration of 16 mu g/ml and bactericidal at 32 mu g/ml. However, G1 is inefficient against non-growing E. coli. Addition of cysteine to medium reduces the antimicrobial potency of G1. Nevertheless, the reaction products of G1 and cysteine enabled prolonged antimicrobial action of the drug. Therefore, the activity of 2-bromo-5-(2-bromo-2-nitrovinyl) furan is a sum of its immediate reactivity and the antibacterial effects of the conversion products.

  • Nelson, Eugene C.
    et al.
    Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
    Nelson, Eugene C.
    Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
    Dixon-Woods, Mary
    Institute of Public Health, University of Cambridge, School of Clinical Medicine, Cambridge, United Kingdom.
    Batalden, Paul B.
    Högskolan i Jönköping, Hälsohögskolan, The Jönköping Academy for Improvement of Health and Welfare. Högskolan i Jönköping, Hälsohögskolan, HHJ. IMPROVE (Improvement, innovation, and leadership in health and welfare). Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
    Homa, Karen
    Dartmouth-Hitchcock Health, Lebanon, NH, United States.
    Van Citters, Aricca D.
    Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
    Morgan, Tamara S.
    Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
    Eftimovska, Elena
    Medical Management Centre, Karolinska Institutet, Stockholm, Sweden.
    Fisher, Elliott S.
    Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
    Ovretveit, John
    Medical Management Centre, Karolinska Institutet, Stockholm, Sweden.
    Harrison, Wade
    Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
    Lind, Cristin
    Quality Register Center Stockholm, Karolinska Institutet, Stockholm County Council, Stockholm, Sweden.
    Lindblad, Staffan
    Medical Management Centre, Karolinska Institutet, Stockholm, Sweden.
    Patient focused registries can improve health, care, and science2016Ingår i: BMJ. British Medical Journal (International Ed.), ISSN 0959-8146, E-ISSN 0959-535X, Vol. 354, i3319Artikel i tidskrift (Refereegranskat)
  • Disputation: 2017-01-26 10:00 V3, Stockholm
    Ghasemifard, Fatemeh
    KTH, Skolan för elektro- och systemteknik (EES), Elektroteknisk teori och konstruktion. KTH.
    Ghasemifard, Fatemeh
    KTH, Skolan för elektro- och systemteknik (EES), Elektroteknisk teori och konstruktion. KTH.
    Remote contact-free reconstruction of currents in two-dimensional parallel conductors2016Licentiatavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    In this thesis, the theory of the remote contact-free reconstruction of currents in two-dimensional parallel conductors is investigated. The motivation of this study is finding a complement technique to measurement transformers which are the well-established devices to measure currents in power transmission lines. This technique would provide the possibility of measuring currents at different locations of a power system, as well as, at different frequencies.

     

    Remote contact-free determination of currents is an electromagnetic inverse source problem in which the currents are reconstructed from the magnetic field data collected by a set of sensors located in the vicinity of the conductors. Since the sensors are not too close to the conductors, the main challenge is the effect of the disturbance fields produced by the external sources in the measurement.

     

    In the case that the external sources produce three-dimensional disturbance fields, the magnetic field due to the external sources is expressed as a truncated expansion of the spherical harmonics and both the currents in the conductors and the expansion coefficients are determined by applying the least square method. To overcome the ill-posedness of the problem, the functional to be minimized is augmented by a Tikhonov regularization term that penalizes unphysical solutions introduced by the expansion coefficients.

     

    Finally, the problem of selecting a limited number of optimal sensor positions among a set of predetermined sensor positions is considered. Using the relaxation method, this optimization problem is changed to a convex optimization problem which can be readily solved using the CVX package.

  • Ogrinc, Greg
    et al.
    VA Outcomes Group, White River Junction VA Medical Center, White River Junction, Vermont.
    Ogrinc, Greg
    VA Outcomes Group, White River Junction VA Medical Center, White River Junction, Vermont.
    Davies, Louise
    VA Outcomes Group, White River Junction VA Medical Center, White River Junction, Vermont.
    Goodman, Daisy
    VA Outcomes Group, White River Junction VA Medical Center, White River Junction, Vermont.
    Batalden, Paul B.
    Högskolan i Jönköping, Hälsohögskolan, The Jönköping Academy for Improvement of Health and Welfare. Högskolan i Jönköping, Hälsohögskolan, HHJ. IMPROVE (Improvement, innovation, and leadership in health and welfare). Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
    Davidoff, Frank
    The Dartmouth Institute for Health Policy and Clinical Practice, Hanover, New Hampshire.
    Stevens, David
    The Dartmouth Institute for Health Policy and Clinical Practice, Hanover, New Hampshire.
    Standards for QUality Improvement Reporting Excellence 2.0: revised publication guidelines from a detailed consensus process2016Ingår i: Journal of Surgical Research, ISSN 0022-4804, E-ISSN 1095-8673, Vol. 200, nr 2, 676-682 s.Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Since the publication of Standards for QUality Improvement Reporting Excellence (SQUIRE 1.0) guidelines in 2008, the science of the field has advanced considerably. In this article, we describe the development of SQUIRE 2.0 and its key components. We undertook the revision between 2012 and 2015 using (1) semistructured interviews and focus groups to evaluate SQUIRE 1.0 plus feedback from an international steering group, (2) two face-to-face consensus meetings to develop interim drafts, and (3) pilot testing with authors and a public comment period. SQUIRE 2.0 emphasizes the reporting of three key components of systematic efforts to improve the quality, value, and safety of health care: the use of formal and informal theory in planning, implementing, and evaluating improvement work; the context in which the work is done; and the study of the intervention(s). SQUIRE 2.0 is intended for reporting the range of methods used to improve health care, recognizing that they can be complex and multidimensional. It provides common ground to share these discoveries in the scholarly literature (www.squire-statement.org).

  • Ogrinc, Greg
    et al.
    Geisel School of Medicine at Dartmouth, Hanover, NH, United States.
    Ogrinc, Greg
    Geisel School of Medicine at Dartmouth, Hanover, NH, United States.
    Davies, Louise
    Geisel School of Medicine at Dartmouth, Hanover, NH, United States.
    Goodman, Daisy
    Geisel School of Medicine at Dartmouth, Hanover, NH, United States.
    Batalden, Paul B.
    Högskolan i Jönköping, Hälsohögskolan, The Jönköping Academy for Improvement of Health and Welfare. Högskolan i Jönköping, Hälsohögskolan, HHJ. IMPROVE (Improvement, innovation, and leadership in health and welfare). Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
    Davidoff, Frank
    Dartmouth Institute for Health Policy and Clinical Practice, Hanover, NH, United States.
    Stevens, David
    Dartmouth Institute for Health Policy and Clinical Practice, Hanover, NH, United States.
    SQUIRE 2.0 (Standards for QUality Improvement Reporting Excellence): Revised publication guidelines from a detailed consensus process2016Ingår i: BMJ Quality and Safety, ISSN 2044-5415, E-ISSN 2044-5423, Vol. 25, nr 12, 986-992 s.Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Since the publication of Standards for QUality Improvement Reporting Excellence (SQUIRE 1.0) guidelines in 2008, the science of the field has advanced considerably. In this manuscript, we describe the development of SQUIRE 2.0 and its key components. We undertook the revision between 2012 and 2015 using (1) semistructured interviews and focus groups to evaluate SQUIRE 1.0 plus feedback from an international steering group, (2) two face-to-face consensus meetings to develop interim drafts and (3) pilot testing with authors and a public comment period. SQUIRE 2.0 emphasises the reporting of three key components of systematic efforts to improve the quality, value and safety of healthcare: the use of formal and informal theory in planning, implementing and evaluating improvement work; the context in which the work is done and the study of the intervention(s). SQUIRE 2.0 is intended for reporting the range of methods used to improve healthcare, recognising that they can be complex and multidimensional. It provides common ground to share these discoveries in the scholarly literature (http://www.squire-statement.org). © Published by the BMJ Publishing Group Limited.

  • Semasaka, Jean Paul S.
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Obstetrik och gynekologi. University of Rwanda College of Medicine and Health Sciences School of Public Health, Kigali, Rwanda.
    Semasaka, Jean Paul S.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Obstetrik och gynekologi. University of Rwanda College of Medicine and Health Sciences School of Public Health, Kigali, Rwanda.
    Krantz, Gunilla
    Nzayirambaho, Manasse
    Munyanshongore, Cyprien
    Edvardsson, Kristina
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Obstetrik och gynekologi. Judith Lumley Centre, La Trobe University, Melbourne, Australia.
    Mogren, Ingrid
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Obstetrik och gynekologi.
    Self-reported pregnancy-related health problems and self-rated health status in Rwandan women postpartum: a population-based cross-sectional study2016Ingår i: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 16, 340Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Self-rated health status (SRH) can be used as a predictor of morbidity and mortality. Postpartum self-rated health has been used to estimate maternal morbidity and postpartum problems. Reproductive history factors are associated with poor self-rated health postpartum. This study investigated prevalence of self-reported health problems during first, second, and third trimesters of pregnancy, delivery, and postpartum. In addition, this study investigated SRH in Rwandan women up to 13 months from partus. Methods: This population-based, cross-sectional study collected data in 2014 using structured interviews (N = 921). Univariable analysis was used to identify variables that were associated with poor self-rated health status (poor-SRH). Logistic regression analyses were performed to identify factors associated with poor-SRH at one day, one week, and one month postpartum and at the time of the interview. Results: Mean time between latest delivery and the time of interview was 7.1 months. Prevalence of anaemia, hypertension, diabetes mellitus during pregnancy, and severe bleeding during pregnancy and labour were 15.0, 4.9, 2.4, and 3.7 %, respectively. The prevalence of poor-SRH was 32.2 % at one day postpartum, 7.8 % at one month, and 11.7 % at time of the interview. Hypertension during pregnancy and significant postpartum haemorrhage were associated with poor-SRH at one day and one week postpartum. Severe bleeding during pregnancy and labour were associated with poor-SRH at one week and one month postpartum. Infection and anaemia during pregnancy were associated with poor-SRH at one month postpartum and at the time of interview. The Kaplan-Meier curves illustrate restitution of health for most women during the study period. Conclusions: This population-based study reports a high prevalence of poor SRH status among Rwandan women in the early postpartum period. Identified factors associated with poor-SRH were severe bleeding, hypertension, infection, and anaemia during pregnancy and postpartum haemorrhage. These factors may be prevented or reduced by providing more frequent and specific attention during pregnancy and by providing timely measures that address complications during delivery, including adequate postpartum care.

  • Noh, H.
    et al.
    Noh, H.
    Alonso, G.
    Nair, Sujith
    Umeå universitet, Samhällsvetenskapliga fakulteten, Handelshögskolan vid Umeå universitet, Företagsekonomi.
    Dahdi, Y.
    Biofuels: their emergence and implications for sustainability in aviation2015Ingår i: Energy and Sustainability V: Special Contributions / [ed] H.H Al-Kayiem; Brebbia, Wessex; S.S. Zubir, Ashurst: WIT Press, 2015, 103-111 s.Konferensbidrag (Refereegranskat)
    Abstract [en]

    The global aviation industry is facing complex and unpredictable market conditions with fluctuating oil prices and the adverse environmental impact of aircraft operations. Since the regulatory approval for biofuels, the first biojet fuel flight test in 2007, using a blend fuel, was a remarkable step towards having more test and schedule flights up to the year of 2014. The purpose of this paper is to engage this new alternative energy with the issues that airlines associate with sustainability, mainly focusing on aircraft operations and profitability. The key findings suggest that the uses of alternative energy need to be in parallel to the reliability and maintainability of the aircraft system, so that the adoption of biofuels can be effective.

  • Åhman, Henrik
    KTH, Skolan för datavetenskap och kommunikation (CSC), Medieteknik och interaktionsdesign, MID.
    Åhman, Henrik
    KTH, Skolan för datavetenskap och kommunikation (CSC), Medieteknik och interaktionsdesign, MID.
    The aesthetic turn: Exploring the religious dimensions of digital technology2016Ingår i: Approaching Religion, ISSN 1799-3121, E-ISSN 1799-3121, Vol. 6, nr 2, 156-163 s.Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The arena for developing digital technology has undergone an aesthetic turn, broadening the focus from a functionalist approach producing centralized systems in the 1970s and 1980s to an increased awareness of the aesthetic aspects of the individual user’s interaction with technology in the 1990s and 2000s. Within the academic research fields studying digital technology (e.g. Human-Computer Interaction and Interaction Design) the aesthetic turn has resulted in a shift from a strong emphasis on user behaviour to an increased interest in aesthetic perspectives on the role of the designer, the design process, and the design material. Within these fields, aesthetics has often been interpreted as belonging to the realm of the individual; personal experiences such as pleasure, engagement, and emotions have been emphasized in both technology development and technology research. Aesthetics is not, however, only an individual phenomenon but also has relational and structural components that need to be acknowledged. Structural aspects of aesthetics condition the possibilities for individuals interacting with digital technology. Thus, the tension between individual and relational aspects of aesthetics in digital technology also reflects a tension between freedom and limitation; between change and permanence; between destabilizing and stabilizing forces. Such a broadened understanding of aesthetics offers a model of digital technology that roughly corresponds to Mark C. Taylor’s definition of religion. Taylor argues that religion is constituted by, on the one hand, a figuring moment characterized by structural stability and universality, and, on the other hand, a disfiguring moment characterized by disruption, particularity, and change. The purpose of this paper is to discuss the aesthetic turn and Taylor’s definition of religion to illustrate similarities between the two, suggesting possible religious dimensions of digital technology and how that can inform our understanding of people’s interaction with digital technology.

  • Batalden, Maren
    et al.
    Department of Medicine, Cambridge Health Alliance, Cambridge, MA, United States.
    Batalden, Maren
    Department of Medicine, Cambridge Health Alliance, Cambridge, MA, United States.
    Batalden, Paul B.
    Högskolan i Jönköping, Hälsohögskolan, The Jönköping Academy for Improvement of Health and Welfare. Högskolan i Jönköping, Hälsohögskolan, HHJ. IMPROVE (Improvement, innovation, and leadership in health and welfare). Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth, Lebanon, NH, United States.
    Margolis, Peter
    Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
    Seid, Michael
    Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
    Armstrong, Gail
    College of Nursing, University of Colorado, Aurora, CO, United States.
    Opipari-Arrigan, Lisa
    Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
    Hartung, Hans
    Department of Pulmonary Medicine, University Hospital Crosshouse, Kilmarnock, East Ayrshire, United Kingdom.
    Coproduction of healthcare service2016Ingår i: BMJ Quality and Safety, ISSN 2044-5415, E-ISSN 2044-5423, Vol. 25, nr 7, 509-517 s.Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Efforts to ensure effective participation of patients in healthcare are called by many names - patient centredness, patient engagement, patient experience. Improvement initiatives in this domain often resemble the efforts of manufacturers to engage consumers in designing and marketing products. Services, however, are fundamentally different than products; unlike goods, services are always 'coproduced'. Failure to recognise this unique character of a service and its implications may limit our success in partnering with patients to improve health care. We trace a partial history of the coproduction concept, present a model of healthcare service coproduction and explore its application as a design principle in three healthcare service delivery innovations. We use the principle to examine the roles, relationships and aims of this interdependent work. We explore the principle's implications and challenges for health professional development, for service delivery system design and for understanding and measuring benefit in healthcare services.

  • Disputation: 2017-02-02 10:00 KTH - room B2, Stockholm
    Samuelsson, Peter
    KTH.
    Samuelsson, Peter
    KTH.
    Management of technology in the process industries:  Matching market and machine2017Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    The process industries span multiple industrial sectors and constitute a substantial part of the entire manufacturing industry. Since companies belonging to this family of industries are often very asset intensive, their ability to respond to changes is often limited in the short term.

    The adaptation of the capabilities of existing processes, and conversely finding products and market segments to match the production system capabilities, are an important part of product- and market development activities in the process industry. The importance to companies in the process industry of having a well-articulated manufacturing strategy congruent with the business strategy is second to none. However, to facilitate manufacturing strategy developments, it is essential to start with an improved characterization and understanding of the material transformation system.

    To that end an extensive set of variables was developed and related measures and scales were defined. The resulting configuration model, focusing on company generic process capabilities in the process industries, is to be regarded as a conceptual taxonomy and as a proposition available for further testing. The usability of the model was subsequently assessed using “mini-cases” in the forestry industry, where the respondents confirmed that the company’s overall strategy could benefit from this kind of platform as a possible avenue to follow.

    The model was deployed as an instrument in the profiling of company material transformation systems to facilitate the further development of companies' functional and business strategies. The use of company-generic production capabilities was studied in three case companies representing the mineral, food and steel industries. The model was found by the respondents to be usable as a knowledge platform to develop production strategies. In the final analysis of the research results, a new concept emerged called “production capability configuration":

    A process-industrial company’s alignment of its generic production capabilities in the areas of raw materials, process technology and products to improve the consistency among the variable elements that define operations and improve the congruence between operations and its environment.

    From the perspective of value creation and capture, firms must be able to manufacture products in a competitive cost structure within the framework of a proper business model. By using the configuration model, the relationship between manufacturing and innovation activities has been studied in the previously mentioned three case studies.

    In many cases the gap in capability appears as a limitation in the production system, requiring development efforts and sometimes investments to overcome. This is illustrated with two examples from the steel industry, where development efforts of the production system capabilities are initiated to better match the market demands. One example is the increase the volume- and product flexibility of an existing stainless steel melt shop, resulting in a proposed oblong Argon Oxygen Decarburisation (AOD) converter configuration that was subsequently verified using water modelling. The second example is from a carbon steel mill, where the target was to increase the raw material- and volume flexibility of another melt shop, by modifying the capabilities of the Electric Arc Furnace (EAF). Enabling EAF technologies are further described and evaluated using operational data and engineering type of estimates. 

  • Ronquist, Fredrik
    et al.
    Naturhistoriska riksmuseet, Enheten för bioinformatik och genetik.
    Ronquist, Fredrik
    Naturhistoriska riksmuseet, Enheten för bioinformatik och genetik.
    Skyttner, Markus
    Naturhistoriska riksmuseet, Enheten för bioinformatik och genetik.
    Kõljalg, Urmas
    Röppert, Dominik
    Penev, Lyubomir
    Stoev, Pavel
    Peer, Israel
    Stein, Martin
    Calabuig, Isabel
    Agosti, Donat
    Kempa, Matus
    EU-BON Deliverable 1.3. Systems for mobilizing and managing collection-based data (specimen + DNA-data) fully integrated2016Rapport (Övrigt vetenskapligt)
    Abstract [en]

    Introduction. A large portion of the biodiversity data in natural history collections is still not available digitally. Increasingly, innovative high-throughput methods are being applied to digitize this backlog in bulk, generating large amounts of data. In parallel, natural history museums are becoming increasingly involved in the generation of large amounts of molecular biodiversity data using new massively parallel sequencing platforms. Against this backdrop, the goal of EU BON Task 1.4 has been to support data mobilization efforts targeting collection-based and molecular data, mainly through the development and integration of innovative open-source tools and services.

    Progress towards objectives. The activities have involved work within the context of three major projects: i) DINA, an open-source, modular, web-based collection management system for natural history specimen data. ii) JACQ an open-access system for botanical (herbarium) data. iii) PlutoF, a web platform for working with traditional and molecular biodiversity research data. The task has also involved work on a number of other EU BON partner systems and services, as well as integration across internal EU BON and external biodiversity informatics resources. Finally, these systems have been used for targeted data mobilization efforts.

    Achievements and current status. Within DINA, the focus has been on supporting the engineering of sophisticated biodiversity information systems through the exploration of tools supporting distributed development and a modular plug-and-play design based on services-oriented architectures. This has involved the testing and adoption of tools like Apiary for the design of Application Programming Interfaces (APIs) and Docker for systems integration and deployment tasks. A Python library for data migration to DINA was also developed and tested. Within JACQ, a number of tools were developed to facilitate deployment and data migration to the system, and the AnnoSys tool for annotation of data has been integrated. Within PlutoF, EU BON efforts focused on the development of a citizen-science module and improved functionality for the mobilization of collection (living) specimen data. A number of innovative tools were developed by Pensoft to help mobilize biodiversity data published in the scientific literature, including semantic mark-up of species conservation papers, direct import of data from a range of biodiversity platforms into manuscripts, and a mechanism for providing stable links from publications to global biodiversity repositories. Plazi implemented an automated workflow mining published scientific papers for taxonomic data, currently mobilizing 25 % of all published new names as they become available. GlueCad developed apps allowing citizen scientists reporting spontaneous observations or systematic inventory data to select target taxa and preferred data mobilization platform. IBSAS and UCPH have focused on national data mobilization efforts targeting Slovakia and Denmark, respectively.

    Future developments. Although the development is clearly towards increased integration of biodiversity informatics tools into larger and more sophisticated systems, it is clear that there is no one size that fits all. Nevertheless, the increasingly widespread adoption of community standards, open-source development practises and service-oriented architectures are pushing the capability of current systems forward and facilitating tighter integration across systems. This trend is supported by the appearance of sophisticated tools enabling the design and deployment of complex modular systems. The adoption of the Docker approach is one example of how the biodiversity informatics community may benefit from this.

  • Palmén, Rachel
    et al.
    Open University of Catalonia, Spain.
    Palmén, Rachel
    Open University of Catalonia, Spain.
    Hearn, Jeff
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Husu, Liisa
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Historical Perspectives and Future Scenarios2016Rapport (Övrigt vetenskapligt)
  • Hearn, Jeff
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Hearn, Jeff
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    From Masculinity to Masculinities and Back to Men … and Fame too …2016Ingår i: Discover Society, Vol. 30Artikel i tidskrift (Övrigt vetenskapligt)