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  • Disputas: 2019-01-18 13:15 K3, Kåkenhus, Norrköping
    Dahlberg, Joen
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Kommunikations- och transportsystem. Linköpings universitet, Tekniska fakulteten.
    Cost allocation methods in cooperative transportation planning2015Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Transportation, together with transportation planning for goods, provides good conditions for economic growth and is a natural part of modern society. However, transportation has negative side effects, including emissions and traffic congestion. A freight forwarder may consolidate shippers’ goods in order to reduce some of the negative side effects, thus reducing emissions and/or congestion as well as operational costs. The negative side effects as well as operational costs can be further reduced if a number of freight forwarders cooperate and consolidate their collective goods flows. Consolidation refers to the process of merging a number of the freight forwarders’ shipments of goods into a single shipment. In this case, the freight forwarders are cooperating with competitors (the other freight forwarders).

    Fair cost allocations are important for establishing and maintaining cost-efficient cooperation among competing stakeholders. Cooperative game theory defines a number of criteria for fair cost allocations and the problem associated with the decision process for allocating costs is referred to as the cost allocation problem. In this thesis, cooperative game theory is used as an academic tool to study cooperation among stakeholders in two transportation planning applications, namely 1) the distribution of goods bound for urban areas and 2) the transportation of wood between harvest areas and industries.

    In transportation planning application 1, there is a cooperation among a number of freight forwarders and a municipality. Freight forwarders’ goods bound for an urban area are consolidated at a facility located just outside the urban area. In this thesis, operational costs for distributing the goods are assessed by solving vehicle routing problems. Common methods from cooperative game theory are used for allocating the operational costs among the freight forwarders and the municipality. In transportation planning application 2, forest companies cooperate in terms of the supply and transportation of common resources, or more specifically, different types of wood. Each forest company has harvest areas and industries to which the wood is transported. The resources may be bartered, that is, the forest companies may transport wood from each other’s harvest areas.

    In the cooperative game theory literature, the stakeholders are often treated equally in the context of transportation planning. However, there seems to be a lack of studies on cooperations where at least one stakeholder differs from the other stakeholders in some fundamental way, for instance, as an initiator or an enabler of the cooperation. Such cooperations are considered in this thesis. The municipality and one of the forest companies are considered to be the initiators in their respective applications.

    Five papers are appended to this thesis and the overall aim is to contribute to the research into cooperative transportation planning by using concepts from cooperative game theory to develop methods for allocating costs among cooperating stakeholders. The purpose of this thesis is to provide decision support for planners in the decisionmaking process of transportation planning to establish cost-efficient and stable cooperations.

    Some of the main outcomes of this thesis are viable and practical methods that could be used in real-life situations to allocate costs among cooperating stakeholders, as well as support for decisionmakers who are concerned with transportation planning. This is done by demonstrating the potential of cooperation, such as cost reduction, and by suggesting how costs can be allocated fairly in the transportation planning applications considered. Lastly, a contribution to cooperative game theory is provided; the introduction of a development of the equal profit method for allocating costs. The proposed version is the equal profit method with lexicography, which, in contrast to the former, guarantees to yield at most one solution to any cost allocation problem. Lexicography is used to rank potential cost allocations and the unambiguously best cost allocation is chosen.  

  • Thorell, Kristina
    Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, Centrum för lärande, kultur och samhälle (CLKS), Lärande, Profession och Samhällsutveckling.
    Communicating the Dark Dimensions of the Past: A Case Study of Museum Management in Västra Götaland2018 (oppl. 1:1)Bok (Annet vitenskapelig)
    Abstract [en]

    Heritage is a result of cultural and social constructions rather than received values from the past (Barrere et al. 2015, p 4 p 4). Dark heritage is a concept which is synonymous to heritage that hurts, difficult heritage, heritage of atrocity and places of pain or shame (Magee & Gilmore 2015, p 900). Dark heritage sites (DHS) are places and institutions “that stand as legacy to painful periods in history; massacre and genocide sites, places related to former penal institutions, prisoners of war, battlefields and many more.” (Magee & Gilmore 2015, p 899). DHS management is a structured activity which supports a meaningful and holistic experience for visitors within the context of diverse and complex servicescapes (Magee & Gilmore 2015, p 899).

    The overall aim of this study is to increase the understanding of how dark dimensions of the past are expressed within museum management in Västra Götaland. In order to fulfil this purpose, three research questions have been formulated: Which dimensions of dark heritage are highlighted? Which ideological approaches permeate the exhibitions of the dark? How is heritage classified as dark heritage?

    The study involved documentary work at Västergötland Museum, Lödöse Museum and the Museum of Gothenburg. The researcher accomplished a documentary work, focusing upon artefacts, information text and multimedia. A qualitative analysis of the data with some inspiration from discourse theory was then carried out. Discourse refers to the meanings and understandings of worldviews that are formed within socio-historical processes (Howarth 2007; Jorgensen & Phillips 2002). Discourse theory provides a framework of how history is constructed and maintained (Howarth 2007). Discourses are transformed and maintained within formal practices and everyday lives (Jorgensen & Phillips 2002, p 12).

    The results show: (1) Dark heritage that is highlighted within the three museums refers to war, conflicts, crimes, sanitary problems, death, epidemics, hard living conditions, and unequal treatment of people. (2) The exhibitions were based on a mixture of different approaches, such as romantic chivalry, local separatist/patriotic, socialistic, and peace/ international understanding approaches (Timothy & Boyd 2003, p 27-28). (3) The discourse within society involves classifications of the dark. It is therefore possible to see a cultural pattern of how war, conflicts, epidemics and sanitary problems become dark dimensions.

  • Palm, Kristina ()
    Karolinska Institutet; KTH.
    Öppen föreläsning: Vägar till ett hållbart digitalt arbetsliv2018Annet (Annet vitenskapelig)
    Abstract [sv]

    Kristina Palm kommer att samtala om konsumtionen av mänskliga resurser inom arbetslivet och hur vi kan forska om samt utveckla och stärka hållbara arbetssystem för ett mer hållbart arbetsliv.

    Kristina Palm, disputerad vid KTH, studerar i sin forskning hållbart arbete och är från 2017 projektledare för forskningsstudien "Vägar till ett hållbart digitalt arbetsliv" som finansieras av AFA Försäkring.

  • Bengtsson, Bengt
    Nordiska museet.
    Stockholmshantverkets rum i Nordiska museet1949Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1949Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Gregorcic, Bor
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Fysikundervisningens didaktik.
    Haglund, Jesper
    Department of Engineering and Physics, Karlstad University.
    Conceptual Blending as an Interpretive Lens for Student Engagement with Technology: Exploring Celestial Motion on an Interactive Whiteboard2018Inngår i: Research in science education, ISSN 0157-244X, E-ISSN 1573-1898Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We present and analyze video data of upper secondary school students’ engagement with a computer-supported collaborative learning environment that enables them to explore astronomical phenomena (Keplerian motion). The students’ activities have an immersive and exploratory character, as students engage in open-ended inquiry and interact physically with the virtual environment displayed on an interactive whiteboard. The interplay of students’ playful exploration through physical engagement with the simulation environment, their attention to physics concepts and laws, and knowledge about the real planets orbiting the Sun presents an analytical challenge for the researcher and instructor encountering such complex learning environments. We argue that the framework of conceptual blending is particularly apt for dealing with the learning environment at hand, because it allows us to take into account the many diverse mental inputs that seem to shape the student activities described in the paper. We show how conceptual blending can be brought together with theoretical ideas concerned with embodied cognition and epistemology of physics, in order to provide researchers and instructors with a powerful lens for looking critically at immersive technology-supported learning environments.

  • Borg, Markus
    et al.
    RISE - Research Institutes of Sweden, ICT, SICS.
    Chatzipetrou, Panagiota
    Blekinge Institute of Technology, Sweden; Örebro University, Sweden.
    Wnuk, Krzysztof
    Blekinge Institute of Technology, Sweden.
    Alégroth, Emil
    Blekinge Institute of Technology, Sweden.
    Gorschek, Tony
    Blekinge Institute of Technology, Sweden.
    Papatheocharous, Efi
    RISE - Research Institutes of Sweden, ICT, SICS.
    Shah, Syed
    iZettle, Sweden.
    Axelsson, Jakob
    RISE - Research Institutes of Sweden, ICT, SICS.
    Selecting Software Component Sourcing Options: Detailed Survey Description and Analysis2018Rapport (Annet vitenskapelig)
    Abstract [en]

    Component-based software engineering (CBSE) is a common approach to develop and evolve contemporary software systems. When evolving a system based on components, make-or-buy decisions are frequent, i.e., whether to develop components internally or to acquire them fromexternal sources. In CBSE, several different sourcing options are available: 1) developing software in-house, 2) outsourcing development, 3) buying commercial-off-the-shelf software, and 4) integrating open source software components. Unfortunately, there is little available research on howorganizations select component sourcing options (CSO) in industry practice. In this work, we seek to contribute empirical evidence to CSO selection. Method: We conduct a cross-domain survey on CSO selection in industry, implemented as an online questionnaire. Based on 188 responses, we find that most organizations consider multiple CSOs during software evolution, and that the CSO decisions in industry are dominated by expert judgment. When choosing between candidate components, functional suitability acts as an initial filter, then reliability is the most important quality. We stress that future solution-oriented work on decision support has to account for the dominance of expert judgment in industry. Moreover, we identify considerable variation in CSO decision processes in industry. Finally, we encourage software development organizations to reflect on their decision processes when choosing whether to make or buy components, and we recommend using our survey for a first benchmarking.

  • Disputas: 2019-02-15 13:15 K2, Kåkenhus, Norrköping
    Ågren, Axel
    Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, Avdelningen Åldrande och social förändring. Linköpings universitet, Filosofiska fakulteten.
    Loneliness among older people in the Swedish media: Constructions, discourses and the designation of responsibility2018Licentiatavhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Feelings of belonging or not belonging to other people are commonly seen as an essential and universal part of human existence. How loneliness is talked about and understood is, however, found to differ depending on historical, cultural and societal contexts. Today, there are intense discussions on loneliness among older people in the Swedish news-press. Constructions within mass media and - in this licentiate thesis - news-press are found to have a significant influence on how older people evaluate their own life and how older people are treated by the surrounding society. Research with this focus is, however, scarce despite the large amount of studies on loneliness and despite research on constructions of older people within mass media being a frequently addressed issue for ageing research. The aim of this thesis is to explore how loneliness among older people is constructed and how the responsibility for reducing loneliness is designated within the Swedish news-press.

    In Paper 1 the empirical material consisted of 94 news-press articles from the years 2013-2014. The prime finding was that loneliness was not the main focus in the articles from the Swedish news-press. The concept was used more to motivate the need for political change, enhancing the importance of volunteer work and described as a risk factor within research reports. The material analysed in Paper 2 consisted of 40 news-press articles from October 2016. The responsibility for reducing loneliness among older people was found to be designated between welfare state institutions on different levels. Institutions and political parties both defend the planned or performed measures to reduce loneliness, but also admit to not doing enough in this regard. Older people were found to be constructed as recipients of activities for reducing loneliness, and the “we” in “society” were those who should perform activities in order to reduce loneliness among older people.

    The main overall finding of the thesis is that loneliness was not the main focus in the articles from Swedish news-press. Instead, loneliness was used as a motive for political change and to enhance the value of volunteer work. Furthermore, loneliness among older people is understood as a problem that needs to be solved. The contexts and logics of the mass media were found to have an influence on how loneliness among older people was constructed, as the issue was mainly addressed in local debate articles with ambitions of achieving change.

  • Lagerquist, Marshall
    Nordiska museet.
    Mästaren bakom en snickarsignatur1949Inngår i: Fataburen: Nordiska museets och SKansens årsbok, Stockholm: Nordiska museets förlag, 1949, s. 189-194Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Unsworth, Richard K. F.
    et al.
    McKenzie, Len J.
    Collier, Catherine J.
    Cullen-Unsworth, Leanne C.
    Duarte, Carlos M.
    Eklöf, Johan S.
    Jarvis, Jessie C.
    Jones, Benjamin L.
    Nordlund, Lina M.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Naturresurser och hållbar utveckling.
    Global challenges for seagrass conservation2018Inngår i: Ambio, ISSN 0044-7447, E-ISSN 1654-7209Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Seagrasses, flowering marine plants that form underwater meadows, play a significant global role in supporting food security, mitigating climate change and supporting biodiversity. Although progress is being made to conserve seagrass meadows in select areas, most meadows remain under significant pressure resulting in a decline in meadow condition and loss of function. Effective management strategies need to be implemented to reverse seagrass loss and enhance their fundamental role in coastal ocean habitats. Here we propose that seagrass meadows globally face a series of significant common challenges that must be addressed from a multifaceted and interdisciplinary perspective in order to achieve global conservation of seagrass meadows. The six main global challenges to seagrass conservation are (1) a lack of awareness of what seagrasses are and a limited societal recognition of the importance of seagrasses in coastal systems; (2) the status of many seagrass meadows are unknown, and up-to-date information on status and condition is essential; (3) understanding threatening activities at local scales is required to target management actions accordingly; (4) expanding our understanding of interactions between the socio-economic and ecological elements of seagrass systems is essential to balance the needs of people and the planet; (5) seagrass research should be expanded to generate scientific inquiries that support conservation actions; (6) increased understanding of the linkages between seagrass and climate change is required to adapt conservation accordingly. We also explicitly outline a series of proposed policy actions that will enable the scientific and conservation community to rise to these challenges. We urge the seagrass conservation community to engage stakeholders from local resource users to international policy-makers to address the challenges outlined here, in order to secure the future of the world’s seagrass ecosystems and maintain the vital services which they supply.

  • Hazelius-Berg, Gunnel
    Nordiska museet.
    Kommentar till en gåva1949Inngår i: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1949, s. 187-188Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Rehnberg, Mats
    Nordiska museet.
    Gungor: några anteckningar kring äldre tiders nöjesliv1949Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1949, s. 157-186Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Svensson, Josefin
    Uppsala universitet, Universitetsförvaltningen, Kommunikationsavdelningen.
    Universen 4:2018: En tidning för Uppsala universitets medarbetare2018Collection/Antologi (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Innehåll i Universen nr 4:2018

    Sid 2: Ledare

    Sid 3: Emma Tysk är årets Uppsalastudent

    Sid 4: Klimatledarskap i praktiken

    Sid 5: Koldioxidbudgetar ska hjälpa kommunerna att nå klimatmålen

    Sid 6: "Det här är det roligaste jobbet"

    Sid 7: Sista Tea-dagen?

    Sid 8: Utmaning att komma från studieovan miljö

    Sid 9: Samarbete för bättre digitala resurser

    Sid 10: Farmaceutiska fakulteten 50 år: "Vi växer hela tiden"

    Sid 12: Flyktingkrisen i fokus för europeiskt forskningsprojekt

    Sid 13: "Som immunolog är det lätt att vara entusiastisk"

    Sid 14: Gifta - och forskarkollegor

    Sid 17: Läsning signerad Uppsala universitet

    Sid 19: Årets topp 10

    Sid 20: Profilen - Stefan Sjöström

  • Wang, Sheng
    et al.
    China Agr Univ, Coll Biol Sci, Beijing, Peoples R China;Natl Inst Biol Sci, Beijing, Peoples R China;Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.
    Mandell, Jeffrey D.
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.
    Kumar, Yogesh
    Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA.
    Sun, Nawei
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.
    Morris, Montana T.
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.
    Arbelaez, Juan
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.
    Nasello, Cara
    Rutgers State Univ, Dept Genet, Piscataway, NJ USA;Rutgers State Univ, Human Genet Inst New Jersey, Piscataway, NJ USA.
    Dong, Shan
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA.
    Duhn, Clif
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.
    Zhao, Xin
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA;Shanghai Jiatong Univ, Sch Med, Xinhua Hosp, Dept Tradit Chinese Med, Shanghai, Peoples R China.
    Yang, Zhiyu
    Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA.
    Padmanabhuni, Shanmukha S.
    Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA.
    Yu, Dongmei
    Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Ctr Genom Med, Boston, MA USA;Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Psychiat & Neurodev Genet Unit, Boston, MA USA.
    King, Robert A.
    Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT USA;Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA.
    Dietrich, Andrea
    Univ Groningen, Univ Med Ctr Groningen, Dept Child & Adolescent Psychiat, Groningen, Netherlands.
    Khalifa, Najah
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Barn- och ungdomspsykiatri. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Gävleborg.
    Dahl, Niklas
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik.
    Huang, Alden Y.
    Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA;Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
    Neale, Benjamin M.
    Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Ctr Genom Med, Boston, MA USA;Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Psychiat & Neurodev Genet Unit, Boston, MA USA.
    Coppola, Giovanni
    Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA;Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
    Mathews, Carol A.
    Univ Florida, Dept Psychiat, Genet Inst, Gainesville, FL 32611 USA.
    Scharf, Jeremiah M.
    Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Ctr Genom Med, Boston, MA USA;Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Psychiat & Neurodev Genet Unit, Boston, MA USA.
    Fernandez, Thomas V.
    Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT USA;Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA.
    Buxbaum, Joseph D.
    Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
    De Rubeis, Silvia
    Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
    Grice, Dorothy E.
    Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
    Xing, Jinchuan
    Rutgers State Univ, Dept Genet, Piscataway, NJ USA;Rutgers State Univ, Human Genet Inst New Jersey, Piscataway, NJ USA.
    Heiman, Gary A.
    Rutgers State Univ, Dept Genet, Piscataway, NJ USA;Rutgers State Univ, Human Genet Inst New Jersey, Piscataway, NJ USA.
    Tischfield, Jay A.
    Rutgers State Univ, Dept Genet, Piscataway, NJ USA;Rutgers State Univ, Human Genet Inst New Jersey, Piscataway, NJ USA.
    Paschou, Peristera
    Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA.
    Willsey, A. Jeremy
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, UCSF Weill Inst Neurosci, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA;Univ Calif San Francisco, QBI, San Francisco, CA 94143 USA.
    State, Matthew W.
    Univ Calif San Francisco, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA;Univ Calif San Francisco, QBI, San Francisco, CA 94143 USA.
    De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis2018Inngår i: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 24, nr 13, s. 3441-+Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We previously established the contribution of de novo damaging sequence variants to Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence an additional 291 TD trios and analyze the combined set of 802 trios. We observe an overrepresentation of de novo damaging variants in simplex, but not multiplex, families; we identify a high-confidence TD risk gene, CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3); we find that the genes mutated in TD patients are enriched for those related to cell polarity, suggesting a common pathway underlying pathobiology; and we confirm a statistically significant excess of de novo copy number variants in TD. Finally, we identify significant overlap of de novo sequence variants between TD and obsessive-compulsive disorder and de novo copy number variants between TD and autism spectrum disorder, consistent with shared genetic risk.

  • Hazelius-Berg, Gunnel
    Nordiska museet.
    Dräktreformer under 1800-talet1949Inngår i: Fataburen: Nordiska museet och Skansens årsbok, Stockholm: Nordiska museets förlag, 1949, s. 127-156Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Mannerfelt, Måns
    Nordiska museet.
    Fyrkanten på Trestena: en västgötaherrgård vid sekelskiftet1949Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1949, s. 107-126Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Manker, Ernst
    Nordiska museet.
    Trolltrumma och seite: något om lapparnas förkristna religion1949Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1949, s. 91-106Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Planer och budget 20192018Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [no]

    Det nordiske budsjettet spiller en sentral rolle som et verktøy for styring og prioritering for det nordiske samarbeidet. Store samfunnsmessige utfordringer har også betydning for det nordiske samarbeidet. Det gjelder hvordan vi eksempelvis møter konsekvenser av geopolitiske endringer, migrasjon og klimautfordringer. Økt internasjonal oppmerksomhet omkring nordiske løsninger representerer nye muligheter. Dette krever et dynamisk og fleksibelt samarbeid hvor budsjettet er et viktig redskap for årealisere nye løsninger på nye utfordringene.

  • Tillhagen, Carl-Herman
    Nordiska museet.
    Folkloristisk fältforskning i 1810-talets Sverige1949Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1949, s. 83-90Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Disputas: 2019-01-25 10:30 H1, Stockholm
    Niazi Ardekani, Mehdi
    KTH, Skolan för teknikvetenskap (SCI), Mekanik.
    Numerical study of transport phenomena in particle suspensions2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Suspensions of solid particles in a viscous liquid are of scientific and technological interest in a wide range of applications. Sediment transport in estuaries, blood flow in the human body, pyroclastic flows from volcanos and pulp fibers in papermaking are among the examples. Often, these particulate flows also include heat transfer among the two phases or the fluid might exhibit a viscoelastic behavior. Predicting these flows and the heat transfer within requires a vast knowledge of how particles are distributed across the domain, how particles affect the flow field and finally how they affect the global behavior of the suspension. The aim of this work is therefore to improve the physical understanding of these flows, including the effect of physical and mechanical properties of the particles and the domain that bounds them.To this purpose, particle-resolved direct numerical simulations (PR-DNS) of spherical/non-spherical particles in different flow regimes and geometries are performed, using an efficient/accurate numerical tool that is developed within this work. The code is based on the Immersed Boundary Method (IBM) for the fluid-solid interactions with lubrication, friction and collision models for the close range particle-particle (particle-wall) interactions, also able to resolve for heat transfer equation in both Newtonian and non-Newtonian fluids.

    Several conclusions are drawn from this study, revealing the importance of the particle's shape and inertia on the global behavior of a suspension, e.g. spheroidal particles tend to cluster while sedimenting. This phenomenon is observed here for both particles with high inertia, sedimenting in a quiescent fluid and inertialess particles (point-like tracer prolates) settling in homogeneous isotropic turbulence. The mechanisms for clustering is indeed different between these two situations, however, it is the shape of the particles that governs these mechanisms, as clustering is not observed for spherical particles. Another striking finding of this work is drag reduction in particulate turbulent channel flow with disk-like spheroidal particles. Again this drag reduction is absent for spherical particles, which instead increase the drag with respect to single-phase turbulence. In particular, we show that inertia at the particle scale induces a non-linear increase of the heat transfer as a function of the volume fraction, unlike the case at vanishing inertia where heat transfer increases linearly within the suspension.

  • Bengtsson, Bengt
    Nordiska museet.
    Den grillska dopskålen1949Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1949, s. 73-82Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Hålenius, Ulf
    et al.
    Naturhistoriska riksmuseet, Enheten för geovetenskap.
    Hatert, Frédéric
    Université de Liège, Belgium..
    Pasero, Marco
    Università di Pisa, Italy..
    Mills, Stuart J.
    Museum Victoria, Melbourne, Australia..
    IMA Commission on New Minerals, Nomenclature and Classification (CNMNC) Newsletter 462018Inngår i: European journal of mineralogy, ISSN 0935-1221, E-ISSN 1617-4011, Vol. 30, nr 6, s. 181-189Artikkel i tidsskrift (Annet vitenskapelig)
  • Kaun, Anne
    et al.
    Södertörns högskola, Institutionen för kultur och lärande, Medie- och kommunikationsvetenskap.
    Treré, Emiliano
    Cardiff University, Cardiff ,UK.
    Repression, resistance and lifestyle: charting (dis)connection and activism in times of accelerated capitalism2018Inngår i: Social Movement Studies, ISSN 1474-2837, E-ISSN 1474-2829Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Studying the nexus of media and social movements is a growing subfield in both media and social movement studies. Although there is an increasing number of studies that criticize the overemphasis of the importance of media technologies for social movements, questions of non-use, technology push-back and media refusal as explicit political practice have received comparatively little attention. The article charts a typology of digital disconnection as political practice and site of struggle bringing emerging literatures on disconnection, i.e. forms of media technology non-use to the field of social movement studies and studies of civic engagement. Based on a theoretical matrix combining questions of power, collectivity and temporality, we distinguish between digital disconnection as repression, digital disconnection as resistance and digital disconnection as performance and life-style politics. The article discusses the three types of digital disconnection using current examples of protest and social movements that engage with practices of disconnection.

  • Mason, David C.
    et al.
    Univ Reading, Dept Geog & Environm Sci, Reading, Berks, England.
    Dance, Sarah L.
    Univ Reading, Dept Meteorol, Reading, Berks, England;Univ Reading, Dept Math & Stat, Reading, Berks, England.
    Vetra-Carvalho, Sanita
    Univ Reading, Dept Meteorol, Reading, Berks, England.
    Cloke, Hannah L.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Luft-, vatten och landskapslära. Univ Reading, Dept Geog & Environm Sci, Reading, Berks, England;Univ Reading, Dept Meteorol, Reading, Berks, England.
    Robust algorithm for detecting floodwater in urban areas using synthetic aperture radar images2018Inngår i: Journal of Applied Remote Sensing, ISSN 1931-3195, E-ISSN 1931-3195, Vol. 12, nr 4, artikkel-id 045011Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Flooding is a major hazard in both rural and urban areas worldwide, but it is in urban areas that the impacts are most severe. High-resolution synthetic aperture radar (SAR) sensors are able to detect flood extents in urban areas during both day- and night-time. If obtained in near real time, these flood extents can be used for emergency flood relief management or as observations for assimilation into flood forecasting models. A method for detecting flooding in urban areas using near real-time SAR data is developed and extensively tested under a variety of scenarios involving different flood events and different images. The method uses an SAR simulator in conjunction with LiDAR data of the urban area to predict areas of radar shadow and layover in the image caused by buildings and taller vegetation. Of the urban water pixels visible to the SAR, the flood detection accuracy averaged over the test examples is 83%, with a false alarm rate of 9%. The results indicate that flooding can be detected in the urban area to reasonable accuracy but that this accuracy is limited partly by the SAR's poor visibility of the urban ground surface due to shadow and layover. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.

  • Semeniuk, Bradley
    et al.
    KTH, Skolan för teknikvetenskap (SCI), Farkost och flyg, MWL Marcus Wallenberg Laboratoriet.
    Göransson, Peter
    KTH, Skolan för teknikvetenskap (SCI), Centra, VinnExcellence Center for ECO2 Vehicle design. Centre for ECO2 Vehicle Design.
    Dazel, Olivier
    Microstructure based modelling of the thermal and viscous dissipation of a transversely isotropic porous fibrous insulation material.2018Konferansepaper (Fagfellevurdert)
  • Hammarsten, Maria
    et al.
    Högskolan i Jönköping, Högskolan för lärande och kommunikation, HLK, Lärandepraktiker i och utanför skolan (LPS), Sustainability Education Research (SER).
    Askerlund, Per
    Högskolan i Jönköping, Högskolan för lärande och kommunikation, HLK, Lärandepraktiker i och utanför skolan (LPS), Sustainability Education Research (SER).
    Almers, Ellen
    Högskolan i Jönköping, Högskolan för lärande och kommunikation, HLK, Lärandepraktiker i och utanför skolan (LPS), Sustainability Education Research (SER).
    Avery, Helen
    Högskolan i Jönköping, Högskolan för lärande och kommunikation, HLK, Lärandepraktiker i och utanför skolan (LPS), Sustainability Education Research (SER).
    Samuelsson, Tobias
    Högskolan i Jönköping, Högskolan för lärande och kommunikation, HLK, Lärandepraktiker i och utanför skolan (LPS), Plats, Identitet, Lärande (PIL).
    Barns perspektiv på att vistas i en skogsträdgård2018Konferansepaper (Fagfellevurdert)
  • Askerlund, Per
    et al.
    Högskolan i Jönköping, Högskolan för lärande och kommunikation, HLK, Lärandepraktiker i och utanför skolan (LPS), Sustainability Education Research (SER).
    Almers, Ellen
    Högskolan i Jönköping, Högskolan för lärande och kommunikation, HLK, Lärandepraktiker i och utanför skolan (LPS), Sustainability Education Research (SER).
    Hur fungerar ekosystemtjänster som verktyg för hållbarhetsarbete på förskolor?2018Konferansepaper (Fagfellevurdert)
  • Henriksson, Göran
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk astrofysik.
    The acceleration of the Moon and the Universe - the Mass of the Graviton2017Inngår i: Advances in Astrophysics, ISSN 2415-6450, Vol. 2, nr 3, s. 184-196Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    To get accurate knowledge about the longitudinal motion of the Moon we must use the oldest preserved interpretable depictions and texts from the ancient cultures. Well documented total solar eclipses from Sumerian cylinder seals, Sumerian, Babylonian, Assyrian, Chinese, Hittite and Greek texts, and depictions on the Swedish rock-carvings from the Bronze Age, have been used in an analysis, performed by the author in 2011, to determine the lunar sidereal secular acceleration. It was based on 33 ancient total or almost total solar eclipses back to 3653 BC. In 2014 and 2016 the margins of error was determined. The new value for the lunar sidereal secular acceleration in longitude = -30.128±0.0035 arcseconds/(century)2 ("/cy2). The lunar secular acceleration, from the Lunar Laser Range (LLR) measurements, -25.856 ±0.003"/cy2, must be corrected for the relativistic effect, -3.604"/cy2, in the Earth-Moon inertial system, to get the lunar sidereal secular acceleration, –29.460 "/cy2, corrected for General Relativity. The difference between this value and the new calibration, -0.668±0.0046"/cy2, corresponds to the cosmological acceleration predicted by Dvali et al. in a Modified Theory of gravity. This value corresponds to a mass of the graviton = 1.306 ±0.009 x 10-56 grams.   If this theory is correct, there is no need for the enigmatic Dark Energy.

  • Murphy, Melissa
    et al.
    University of Oxford.
    Porcelli, Don
    University of Oxford.
    Pogge von Strandmann, Philip
    University College London.
    Hirst, Catherine
    Naturhistoriska riksmuseet, Enheten för geovetenskap.
    Kutscher, Liselott
    Naturhistoriska riksmuseet, Enheten för geovetenskap.
    Katchinoff, Joachim
    Yale University.
    Mörth, Carl-Magnus
    Stockholm University.
    Maximov, Trofim
    Institute for Biological Problems in the Cryolitic Zone, Yakutsk.
    Andersson, Per
    Naturhistoriska riksmuseet, Forskningsavdelningen centralt.
    Tracingsilicate weathering processes in the permafrost-dominated Lena River watershedusing lithium isotopes2019Inngår i: Geochimica et Cosmochimica Acta, ISSN 0016-7037, E-ISSN 1872-9533, Vol. 245, s. 154-171Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Increasing global temperatures are causing widespread changes in the Arctic, including permafrost thawing and altered freshwater inputs and trace metal and carbon fluxes into the ocean and atmosphere. Changes in the permafrost active layer thickness can affect subsurface water flow paths and water-rock interaction times, and hence weathering processes. Riverine lithium isotope ratios (reported as δ7Li) are tracers of silicate weathering that are unaffected by biological uptake, redox, carbonate weathering and primary lithology. Here we use Li isotopes to examine silicate weathering processes in one of the largest Russian Arctic rivers: the Lena River in eastern Siberia. The Lena River watershed is a large multi-lithological catchment, underlain by continuous permafrost. An extensive dataset of dissolved Li isotopic compositions of waters from the Lena River main channel, two main tributaries (the Aldan and Viliui Rivers) and a range of smaller sub tributaries are presented from the post-spring flood/early-summer period at the onset of active layer development and enhanced water-rock interactions. The Lena River main channel (average δ7Lidiss ~19‰) has a slightly lower isotopic composition than the mean global average of 23‰ (Huh

    et al., 1998a). The greatest range of [Li] and δ7Lidiss are observed in catchments draining the south facing slopes of the Verkhoyansk Mountain Range. South-facing slopes in high-latitude, permafrost dominated regions are typically characterised by increased summer insolation and higher daytime temperatures relative to other slope aspects. The increased solar radiation on south-facing catchments promotes repeated freeze-thaw cycles, and contributes to more rapid melting of snow cover, warmer soils, and increased active layer thaw depths. The greater variability in δ7Li and [Li] in the south-facing rivers likely reflect the greater infiltration of melt water and enhanced water rock interactions within the active layer. A similar magnitude of isotopic fractionation is observed between the low-lying regions of the Central Siberian Plateau (and catchments draining into the Viliui River), and catchments draining the Verkhoyansk Mountain Range into the Aldan River. This is in contrast to global rivers in non permafrost terrains that drain high elevations or areas of rapid uplift, where high degrees of physical erosion promote dissolution of freshly exposed primary rock typically yielding low δ7Lidiss, and low lying regions exhibit high riverine δ7Li values resulting from greater water-rock interaction and formation of secondary mineral that fractionates Li isotopes. Overall, the range of Li concentrations and δ7Lidiss observed within the Lena River catchment are comparable to global rivers located in temperate and tropical regions. This suggests that cryogenic weathering features specific to permafrost regions (such as the continual exposure of fresh primary minerals due to seasonal freeze-thaw cycles, frost shattering and salt weathering), and climate (temperature and runoff), are not a dominant control on δ7Li variations. Despite vastly different climatic and weathering regimes, the same range of riverine δ7Li values globally suggests that the same processes govern Li geochemistry – that is, the balance between primary silicate mineral dissolution and the formation (or exchange with) secondary minerals. This has implications for the use of δ7Li as a palaeo weathering tracer for interpreting changes in past weathering regimes.

  • Phoosuwan, Nitikorn
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Vårdvetenskap.
    Eriksson, Leif
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Vårdvetenskap.
    Lundberg, Pranee C.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Vårdvetenskap.
    Statistical Analyses Of The Thai Version Of The Edinburgh Postnatal Depression Scale Among Thai Women During The Antenatal Period In North-Eastern Thailand2017Konferansepaper (Fagfellevurdert)
  • Rodin, Sergey
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper. Karolinska Inst, Dept Med Biochem & Biophys, Div Physiol Chem 1, Scheelesvag 2, SE-17177 Stockholm, Sweden.
    Rebellato, Paola
    Biothema AB, Handens Stn Vag 17, S-13640 Handen, Sweden.
    Lundin, Arne
    Biothema AB, Handens Stn Vag 17, S-13640 Handen, Sweden.
    Zubarev, Roman A.
    Karolinska Inst, Dept Med Biochem & Biophys, Div Physiol Chem 1, Scheelesvag 2, SE-17177 Stockholm, Sweden;IM Sechenov First Moscow State Med Univ, Dept Pharmacol & Technol Chem, Moscow, Russia.
    Isotopic resonance at 370 ppm deuterium negatively affects kinetics of luciferin oxidation by luciferase2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 16249Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Since 1930s, it has been known that some biochemical and biological processes exhibit abnormal kinetics at a deuterium concentration in the local environment of 250-600 ppm, which is 2-4 times higher that the normal concentration of 150 ppm D. We sought to test if the kinetics of firefly luciferase oxidizing luciferin, the reaction widely used as a read-out in various biochemical assays, is also affected by an elevated deuterium content. To this end, both luciferase and luciferin substrate solutions were prepared based on water with extra deuterium added to a concentration ranging from 150 ppm and up to 10,000 ppm (1%). Upon mixing the solutions, the luminescence intensity at different times was compared with that of the corresponding control solutions with 150 ppm D. A broad negative resonance was detected (p < 10(-6)), with a approximate to 20% drop in luminescence at 370 ppm D. Given that, on average, about half of hydrogen atoms in proteins are not exchangeable in solution, this value corresponds to approximate to 260 ppm of deuterium in all enzyme's hydrogens, in a very good agreement with the prediction of the Isotopic resonance hypothesis.

  • Lim Falk, Maria
    et al.
    Stockholms universitet, Humanistiska fakulteten, Institutionen för svenska och flerspråkighet, Svenska/Nordiska språk.
    Wirdenäs, Karolina
    Stockholms universitet, Humanistiska fakulteten, Institutionen för svenska och flerspråkighet, Svenska/Nordiska språk.
    Skrivande på gymnasiet: Perspektiv på skrivutveckling och textkompetens2018Annet (Annet vitenskapelig)
    Abstract [sv]

    Elevernas skrivutveckling når aldrig ett slutmål – nya genrer och nytt innehåll innebär nya utmaningar och fler steg i utvecklingen mot en avancerad skriftspråkskompetens. En utvecklande skrivundervisning behöver göra eleverna förberedda att möta dessa utmaningar, både under gymnasietiden och i kommande studier och yrkesliv.

    Artikeln föreskriver inte en specifik teoribildning eller en utvald skrivpedagogisk inriktning som svar på hur undervisningen kan möta elevernas behov. Den betonar istället att lärare behöver många redskap och göra medvetna val bland dessa i planeringen av en skrivundervisning som ser till alla delar i den skriftspråkliga kompetensen.

    Artikeln resonerar kring de tendenser som genom åren har präglat skrivundervisningen. Hur ska dagens lärare förhålla sig till olika synsätt och inriktningar? En breddad skrivundervisning förespråkas som på olika sätt främjar utvecklingen av elevernas skriftspråkliga kompetens.

  • Disputas: 2019-01-25 13:00 Kollegiesalen, Stockholm
    Gürdür, Didem
    KTH, Skolan för industriell teknik och management (ITM), Maskinkonstruktion (Inst.), Mekatronik.
    Data and Visual Analytics for Cyber-physical Systems: Current Situation and Strategies for Action2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Today, cyber-physical systems (CPS) exist everywhere in different sizes, with different functionalities and capabilities. CPS often support critical missions that have significant economic and societal importance. They require software systems, communications technologies, sensors/actuators, embedded technologies, and physical systems to work together seamlessly, and they are seen as a driving force behind digital transformation. This dissertation describes the research work carried out to investigate applicability of data and visual analytics for CPS to overcome three main challenges: interoperability, complexity, and sustainability.

    To this end, several case studies are used to effectively implement and test different data and visual analytics solutions to aid stakeholders when they make decisions on interoperability, complexity, and sustainability for CPS. These studies raised questions about issues found to be of importance for the success of data and visual analytics approaches, including accessibility, availability, quality, volume, and variety of data—issues. Moreover, additional studies are used to show the benefits of blending different approaches, such as systems thinking and design thinking, and the current data analytics readiness of the Swedish industry is assessed through a questionnaire completed by more than a hundred respondents. 

    The data and visual analytics are positioned between digitalization and machine intelligence as a research focus. Data and visual analytics is the next step after digitalizing the information by adding analytical capabilities to the data. It is also an important phase before developing machine intelligence applications. Earlier studies clearly show that only a fraction of companies have machine intelligence applications across the enterprise. One important reason behind this is the lack of strong digital capabilities that big data and advanced data analytics technologies could bring. The findings of the work carried out as part of this thesis show the importance of this middle phase—data and visual analytics—for the success of not only the CPS but also these two concepts—digitalization and machine intelligence.

    This thesis concludes by highlighting that currentdata and visual analytics approaches in CPS are closely dependent onthe availability, accessibility, quality, volume, and variety of the data. Notably, the huge amount of industrial data that exists in CPS manufacturers data repositories does not always mean that this data is useful, especially for analytical purposes. To this end, firstly, the CPS industry should concentrate its efforts to collect useful data that will benefit the industry by providing analytical insight intothe environments where CPS is produced and operated. Secondly, the industry should make necessary organizational changes such as considering to employ data scientists, analysts, and business intelligence developers and make data accessible tothese people for further usage. Thirdly, the data management procedures and data analytics roadmaps of companies should be created and shared with other employees, and necessary mechanisms needto be considered to improve and guarantee the quality of the data. Lastly, the variety of data needs to be addressed by the industry. 

    Data and visual analytics provides an opportunity to extract patterns; to evaluate the interoperability, complexity, and sustainability; to create an overview of the current challenge by providing different viewpoints adapted to different stakeholders, focusing on key concerns for the respective stakeholder; to optimize performance, automation, and cooperation of distributed CPS, development environment, and teams; and overall, to improve any of the challenges that are mentioned above by, basically, providing a better understanding.

    To this end, I suggest that the industry discuss the next step after digitalization and address the challenges related to the availability, accessibility, quality, volume, and variety of data by considering user-centric approaches and organizational needs of the future development and manufacturing environments. The CPS industry should plan and act on these challenges as part of its data analytics strategies to expedite the machine intelligence applications of the future.

  • Karademir, Betul
    et al.
    Marmara Univ, Sch Med, Dept Biochem, Genet & Metab Dis Res & Invest Ctr, Istanbul, Turkey.
    Sari, Gulce
    Marmara Univ, Sch Med, Dept Biochem, Genet & Metab Dis Res & Invest Ctr, Istanbul, Turkey;Okan Univ, Fac Engn, Dept Genet & Bioengn, Istanbul, Turkey.
    Jannuzzi, Ayse Tarbin
    Istanbul Univ, Fac Pharm, Dept Pharmaceut Toxicol, Istanbul, Turkey.
    Musunuri, Sravani
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Wicher, Grzegorz
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Neuroonkologi.
    Grune, Tilman
    German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Mol Toxicol, D-14558 Nuthetal, Germany;German Ctr Diabet Res DZD, D-85764 Munich, Germany;German Ctr Cardiovasc Res DZHK, D-10117 Berlin, Germany.
    Mi, Jia
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi. Binzhou Med Univ, Med & Pharm Res Ctr, Yantai, Peoples R China.
    Hacioglu-Bay, Husniye
    Marmara Univ, Sch Med, Dept Anat, Istanbul, Turkey.
    Forsberg-Nilsson, Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Neuroonkologi.
    Bergquist, Jonas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Jung, Tobias
    German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Mol Toxicol, D-14558 Nuthetal, Germany;German Ctr Diabet Res DZD, D-85764 Munich, Germany;German Ctr Cardiovasc Res DZHK, D-10117 Berlin, Germany.
    Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 16318Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The proteasomal system is responsible for the turnover of damaged proteins. Because of its important functions in oncogenesis, inhibiting the proteasomal system is a promising therapeutic approach for cancer treatment. Bortezomib (BTZ) is the first proteasome inhibitor approved by FDA for clinical applications. However neuropathic side effects are dose limiting for BTZ as many other chemotherapeutic agents. Therefore second-generation proteasome inhibitors have been developed including carfilzomib (CFZ). Aim of the present work was investigating the mechanisms of peripheral neuropathy triggered by the proteasome inhibitor BTZ and comparing the pathways affected by BTZ and CFZ, respectively. Neural stem cells, isolated from the cortex of E14 mouse embryos, were treated with BTZ and CFZ and mass spectrometry was used to compare the global protein pool of treated cells. BTZ was shown to cause more severe cytoskeletal damage, which is crucial in neural cell integrity. Excessive protein carbonylation and actin filament destabilization were also detected following BTZ treatment that was lower following CFZ treatment. Our data on cytoskeletal proteins, chaperone system, and protein oxidation may explain the milder neurotoxic effects of CFZ in clinical applications.

  • Lim Falk, Maria
    Stockholms universitet, Humanistiska fakulteten, Institutionen för svenska och flerspråkighet, Svenska/Nordiska språk.
    Planera för progression2018Annet (Annet vitenskapelig)
    Abstract [sv]

    För att planera en undervisning med fokus på språklig progression behöver man utgå från nyanlända elevers förutsättningar och behov så att de får både kognitiva utmaningar och adekvat stöttning. Artikeln introducerar registermodellen som en teoretisk ram för att beskriva språkutveckling, språkanvändning och språklig variation i olika sammanhang.

  • Albaalbaky, Ahmed
    et al.
    Normandie Univ, UNIROUEN, INSA Rouen, CNRS,GPM, F-76800 St Etienne Du Rouvray, France.
    Kvashnin, Yaroslav
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori.
    Patte, Renaud
    Normandie Univ, UNIROUEN, INSA Rouen, CNRS,GPM, F-76800 St Etienne Du Rouvray, France.
    Fresard, Raymond
    Normandie Univ, CRISMAT, CNRS, UNICAEN,ENSICAEN, F-14050 Caen, France.
    Ledue, Denis
    Normandie Univ, UNIROUEN, INSA Rouen, CNRS,GPM, F-76800 St Etienne Du Rouvray, France.
    Effects of Ga doping on magnetic and ferroelectric properties of multiferroic delafossite CuCrO2: Ab initio and Monte Carlo approaches2018Inngår i: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 98, nr 17, artikkel-id 174403Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The effects of nonmagnetic impurity doping on magnetic and ferroelectric properties of multiferroic delafossite CuCrO2 are investigated by means of density functional theory calculations and Monte Carlo simulations. Density functional theory calculations show that replacing up to 30% of Cr3+ ions by Ga3+ ones does not significantly affect the remaining Cr-Cr superexchange interactions. Monte Carlo simulations show that CuCr1-xGaxO2 preserves its magnetoelectric properties up to x similar or equal to 0.15 with a spiral ordering, while it becomes disordered at higher fractions. Antiferromagnetic transition shifts towards lower temperatures with increasing x and eventually disappears at x >= 0.2. Our simulations show that Ga3+ doping increases the Curie-Weiss temperature of CuCr1-xGaxO2, which agrees well with experimental observations. Moreover, our results show that the incommensurate ground-state configuration is destabilized by Ga3+ doping under zero applied field associated with an increase of frustration. Finally, coupling between noncollinear magnetic ordering and electric field is reported for x <= 0.15 through simulating P-E hysteresis loops, which leads to ferroelectricity in the extended inverse Dzyaloshinskii-Moriya model.

  • Lim Falk, Maria
    et al.
    Stockholms universitet, Humanistiska fakulteten, Institutionen för svenska och flerspråkighet, Svenska/Nordiska språk.
    Almström Persson, Gunilla
    Stockholms universitet, Humanistiska fakulteten, Institutionen för svenska och flerspråkighet, Svenska/Nordiska språk.
    Bygga och värdera kunskap: Texter av vetenskaplig karaktär2018Annet (Annet vitenskapelig)
    Abstract [sv]

    Artikeln handlar om vetenskapligt skrivande. Många läroböcker och skrivhandledningar tar upp den vetenskapliga textens disposition, språk och stil. Här ligger i stället fokus på hur övningar i att värdera kunskap och information kan främja ett kritiskt-analytiskt förhållningssätt som en grundläggande förutsättning för att kunna skriva texter av vetenskaplig karaktär.

  • Nikolaidou, Zoe
    et al.
    Södertörns högskola, Institutionen för kultur och lärande, Svenska.
    Bellander, Theres
    Stockholm Univeristy.
    Health literacy as knowledge construction: Learning about health by expanding objects and crossing boundaries in networked activities2018Inngår i: Learning, Culture and Social Interaction, ISSN 2210-6561, E-ISSN 2210-657XArtikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    In this paper we examine health literacy as a set of practices that unfold in networked activity systems. Focusing on the literacy practices of pregnant couples and parents of children with heart defect, we show that they participate in multiple activities with the object of constructing knowledge about the child's condition. The contexts for these activities are doctor-patient consultations and the parents' online searching and sharing. The study builds on ethnographic interviews, recorded medical consultations and collection of texts from online forums, blogs and social media. An analysis based on literacy practices and activity theory shows that these activities enable parents' learning, but they can also be restricting as to the mediating tools they provide and the rules that dictate the tools. Additionally, the object of learning about heart defect is not always clearly formulated and stable but it keeps alternating and expanding. As a result, the parents cross boundaries between activities with different mediating tools, rules and communities and thereby different possibilities for learning. We show that doing health literacy is comprised by a set of recontextualised practices of looking for medical and experiential knowledge and it is by a combination of the two that meaningful learning is achieved.

  • Hansson, Katarina
    et al.
    IVL Swedish Environmental Research Institute.
    Andersson, Hanna
    IVL Swedish Environmental Research Institute.
    Ejhed, Heléne
    IVL Swedish Environmental Research Institute.
    Liljeberg, Marcus
    IVL Swedish Environmental Research Institute.
    Olshammar, Mikael
    IVL Swedish Environmental Research Institute.
    Skårman, Tina
    IVL Swedish Environmental Research Institute.
    Sörme, Louise
    SCB Statistics Sweden.
    Dunsö, Olof
    SCB Statistics Sweden.
    Segersson, David
    SMHI Swedish Meteorological and Hydrological Institute.
    Diffuse emissions to air and water2012Rapport (Annet vitenskapelig)
    Abstract [en]

    The Swedish environmental reporting system has large amounts of information regarding point source discharges. But, point sources represent only a limited part of the total discharges. Therefore contributions from diffuse sources are important to identify in relation to the spread of various substances to the environment. Ex-amples of diffuse sources include road traffic, agriculture, use of solvents, chemi-cals emitted from use-phase of products, and small industries. Here, these and simi-lar diffuse emissions to air are published in the Swedish Pollutant Release and Transfer Register (S-PRTR, with Swedish acronym UTIS). This data is derived from the air and climate reporting made to the Convention on Long-range Trans-boundary Air Pollution (CLRTAP) and UNFCCC. Data at the S-PRTR is listed for several organic pollutants, such as PAHs and heavy metals. Data on diffuse emis-sions to water is currently not provided at the S-PRTR website. Certain diffuse emissions into water are included in the international emission reporting, such as the HELCOM PLC periodical and EEA WISE SoE Emissions.

    The project described herein is based on the development project "Feasibility study for possible publication of diffuse emissions at SPRTR, and is designed to:

     Publish data on emissions from diffuse sources, primarily to water, from selected sectors and substances or substance groups.

     Compare data collected for these diffuse emissions in relation to totals for data reported to E-PRTR.

     Based on the knowledge acquired during this project to propose more regu-lar procedures for collecting data regarding diffuse emissions.

    Substances considered in the project include nutrients (nitrogen and phosphorus), metals (lead, cadmium, copper, mercury, nickel and zinc) and certain organic com-pounds (PAHs, PBDEs, nonylphenols, PCBs, HCHs, DDT, endosulfan, and diox-ins. There is currently no data in certain matrices for these organic pollutants.

    The project has four separate subprojects:

     Diffuse emissions of metals and nutrients to water.Diffuse emissions of certain organic pollutants to water.Diffuse emissions of nonylphenols and nonylphenol ethoxylates from different product groups.Analyses of report-ed data for air and water, and comparison with diffuse emissions.Project 1 covers the following diffuse sources: atmospheric deposition on water, forest land, agriculture, other land, stormwater, local on-site wastewater treatment facilities, industrial facilities and wastewater treatment plants not included in reporting to E-PRTR. Copper is also considered as emission from antifouling boat paint. Subpro-ject 1 findings show that the most significant emission source for nitrogen and phosphorus is agricultural and forests land. Forests dominate as the source of all metals. As well, diffuse emissions of most other metal are significant from agricul-ture, deposition on water, other land and stormwater. Geographically, distribution of emissions shows that stormwater is more significant in the south (Northern Baltic, Southern Baltic, and Skagerrak and Kattegat river basin districts) than in the north (Bothnian Bay and Bothnian Sea river basin districts). This is as expected due to greater traffic volumes in the south. In future, data from water load reporting can be easily recalculated in the geo-database to match publication in the E-PRTR. Coordinating with departments producing water emission statistics is necessary, though.

    Subproject 2 findings show that data for only a few organic pollutants is currently available (such as PAHs, PBDEs, nonylphenols, dioxins, DEHP, PCBs, HCH, DDT, endosulfan and chlorinated paraffins). Data for many of these substances is available only for single or a few diffuse sources (small industries and WWTPs, deposition on water, stormwater and deposition on land). Data for diffuse emis-sions of organic pollutants that is currently available are uncertain and based on few measurements.

    Subproject 3 shows that it is possible to estimate nonylphenols (NPequ) emissions to air, soil and wastewater. The largest source of NPequ to wastewater is from textiles, while smaller amounts are from detergents. The data are uncertain, however, as they are based on emission factors with significant uncertainties.

    Finally,subproject 4 findings show that all diffuse emissions are significant. Dif-fuse emission of nitrogen, phosphorus and metals to water is at least 10 times or more larger compared to point sources, in nearly all cases. Agricultural land domi-nates as a source in the case of phosphorus and nitrogen. Emissions of organic pollutants to water show significant gaps in the data because very few companies report emissions.

    Regarding emissions of organic pollutants and metals to the air, the difference between point sources (E-PRTR) and diffuse emissions based on data from CLRTAP are in most cases not as great as for water. For copper, diffuse emissions to air from brake linings is the largest source of diffuse emission (>90%). And for PAH, diffuse emissions from the energy sector dominates, corresponding to nearly 100% of the total. Emissions of each pollutant (nearly all) is greater to water than to air for point sources, diffuse sources, and the total.

    When comparing emissions from various industries, findings show that forestry industry facilities contribute approximately 90% when it comes to cadmium emis-sions to water from point sources according to E-PRTR (total 440 kg). Still, this is much lower than diffuse emissions as found in Subproject 1, 3,900 kg – indicating diffuse emissions are nearly 9 times greater. The difference for emissions to water is not very large between point sources reported to E-PRTR and those not (in the e-PRTR) – indicating that the point sources under E-PRTR include a large portion of all discharges from point sources to water.

    The quality of data is sufficient to show diffuse emission levels of nutrients and metals at the S-PRTR, reported for the national, river basin district or more refined levels, since this data is based on values reported to the EU and HELCOM. Re-garding organic pollutants to water and nonylphenols from products, the data is more uncertain and is therefore not recommended to be published in the S-PRTR. For emissions to air, our conclusion is that national totals, as reported to the UNPCCC and CLRTAP can be included in the S-PRTR.

  • Schoemaker, Minouk J.
    et al.
    Nichols, Hazel B.
    Wright, Lauren B.
    Brook, Mark N.
    Jones, Michael E.
    O'Brien, Katie M.
    Adami, Hans-Olov
    Baglietto, Laura
    Bernstein, Leslie
    Bertrand, Kimberly A.
    Boutron-Ruault, Marie-Christine
    Braaten, Tonje
    Chen, Yu
    Connor, Avonne E.
    Dorronsoro, Miren
    Dossus, Laure
    Eliassen, A. Heather
    Giles, Graham G.
    Hankinson, Susan E.
    Kaaks, Rudolf
    Key, Timothy J.
    Kirsh, Victoria A.
    Kitahara, Cari M.
    Koh, Woon-Puay
    Larsson, Susanna C.
    Linet, Martha S.
    Ma, Huiyan
    Masala, Giovanna
    Merritt, Melissa A.
    Milne, Roger L.
    Overvad, Kim
    Ozasa, Kotaro
    Palmer, Julie R.
    Peeters, Petra H.
    Riboli, Elio
    Rohan, Thomas E.
    Sadakane, Atsuko
    Sund, Malin
    Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap.
    Tamirni, Rulla M.
    Trichopoulou, Antonia
    Ursin, Giske
    Vatten, Lars
    Visvanathan, Kala
    Weiderpass, Elisabete
    Willett, Walter C.
    Wolk, Alicja
    Yuan, Jian-Min
    Zeleniuch-Jacquotte, Anne
    Sandler, Dale P.
    Swerdlow, Anthony J.
    Association of body mass index and age With subsequent breast cancer risk in premenopausal women2018Inngår i: JAMA Oncology, ISSN 2374-2437, E-ISSN 2374-2445, Vol. 4, nr 11, artikkel-id e181771Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    IMPORTANCE The association between increasing body mass index (BMI; calculated as wei ght in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover effect exists, with risk reduction before and risk increase after menopause. The inverse association with premenopausal breast cancer risk is poorly characterized but might be important in the understanding of breast cancer causation.

    OBJECTIVE To investigate the association of BMI with premenopausal breast cancer risk, in particular by age at BMI, attained age, risk factors for breast cancer, and tumor characteristics.

    DESIGN, SETTING, AND PARTICIPANTS This multicenter analysis used pooled individual-level data from 758 592 premenopausal women from 19 prospective cohorts to estimate hazard ratios (HRs) of premenopausal breast cancer in association with BMI from ages 18 through 54 years using Cox proportional hazards regression analysis. Median follow-up was 9.3 years (interquartile range, 4.9-13.5 years) per participant, with 13 082 incident cases of breast cancer. Participants were recruited from January 1,1963, through December 31, 2013, and data were analyzed from September 1.2013, through December 31, 2017.

    EXPOSURES Body mass index at ages 18 to 24, 25 to 34,35 to 44, and 45 to 54 years.

    MAIN OUTCOMES AND MEASURES Invasive or in situ premenopausal breast cancer.

    RESULTS Among the 758 592 premenopausal women (median age, 40.6 years; interquartile range, 35.2-45.5 years) included in the analysis, inverse linear associations of BMI with breast cancer risk were found that were stronger for BMI at ages 18 to 24 years (HR per 5 kg/m(2) [5.0-U] difference, 0.77; 95% CI, 0.73-0.80) than for BMI at ages 45 to 54 years (HR per 5.0-U difference, 0.88; 95% CI, 0.86-0.91). The inverse associations were observed even among nonoverweight women. There was a 4.2-fold risk gradient between the highest and lowest BMI categories (BMI >= 35.0 vs <17.0) at ages 18 to 24 years (HR, 0.24; 95% CI, 0.14-0.40). Hazard ratios did not appreciably vary by attained age or between strata of other breast cancer risk factors. Associations were stronger for estrogen receptor-positive and/or progesterone receptor-positive than for hormone receptor-negative breast cancer for BMI at every age group (eg, for BMI at age 18 to 24 years: HR per 5.0-U difference for estrogen receptor-positive and progesterone receptor-positive tumors, 0.76 [95% CI, 0.70-0.81] vs hormone receptor-negative tumors, 0.85 [95% CI: 0.76-0.95]); BMI at ages 25 to 54 years was not consistently associated with triple-negative or hormone receptor-negative breast cancer overall.

    CONCLUSIONS AND RELEVANCE The results of this study suggest that increased adiposity is associated with a reduced risk of premenopausal breast cancer at a greater magnitude than previously shown and across the entire distribution of BMI. The strongest associations of risk were observed for BMI in early adulthood. Understanding the biological mechanisms underlying these associations could have important preventive potential.

  • Skyving, Marie
    et al.
    Transportstyrelsen.
    Forsman, Åsa
    Statens väg- och transportforskningsinstitut, Trafik och trafikant,TRAF, Trafiksäkerhet och trafiksystem, TST.
    Dukic Willstrand, Tania
    Statens väg- och transportforskningsinstitut, Trafik och trafikant,TRAF, Trafikanttillstånd, TIL.
    Samband mellan sjukdomar och äldre bilförares inblandning i trafikolyckor2018Rapport (Annet vitenskapelig)
    Abstract [sv]

    Sverige är ett av få länder inom EU som inte har obligatoriska hälsokontroller för förare över en viss ålder. Vår motivering är att man inte kunnat påvisa positiva trafiksäkerhetseffekter av sådana kontroller. Den här studien utreder om personbilsförare som är 65 år eller äldre och som har en sjukdomsdiagnos oftare är inblandade i trafikolyckor jämfört med förare i samma ålder och utan diagnos. 

    Forskningsstudien har sin utgångspunkt i de trafikmedicinska föreskrifterna och de 13 diagnosgrupperna som beskrivs i föreskrifternas olika kapitel. För att undersöka om äldre bilförare med en sjukdomsdiagnos har högre olycksrisk än äldre bilförare utan diagnos har vi matchat en fallpopulation på 13 700 olycksinblandade förare som var 65 år eller äldre med en kontrollgrupp. Kontrollgruppen bestod av 26 500 åldersmatchade personer som skulle uppfylla tre krav: ha giltigt B-körkort (personbil), vara bilägare och inte ha varit inblandade i någon trafikolycka. 

    De register som vi använt oss av är 

     Transportstyrelsens olycksdatabas Strada

     Statistiska centralbyråns befolkningsregister

     Socialstyrelsens patientregister.

    Studien begränsas av ett antal faktorer, till exempel att vi saknar uppgift om exponering i trafik och föreskrivna läkemedel, för att nämna några. Det här innebär bland annat att vi inte kan säga om en t. ex. förhöjd sannolikhet för olycka beror på försämrad körförmåga eller att man kör mer bil och att man därmed är mer exponerad i trafiken. 

  • Östman, Sofi
    Umeå universitet, Humanistiska fakulteten, Institutionen för idé- och samhällsstudier, Miljöarkeologiska laboratoriet.
    Makrofossilanalys av jordprover från kulturlager inom Sandarnaboplatsen, Raä Göteborg 15:1, Västergötland2018Rapport (Annet vitenskapelig)
  • Östman, Sofi
    Umeå universitet, Humanistiska fakulteten, Institutionen för idé- och samhällsstudier, Miljöarkeologiska laboratoriet.
    Makrofossilanalys av sex prover från en boplatsmiljö inom Raä 218, Växjö socken, Småland2018Rapport (Annet vitenskapelig)
  • Wallin, Jan-Erik
    et al.
    Östman, Sofi
    Umeå universitet, Humanistiska fakulteten, Institutionen för idé- och samhällsstudier, Miljöarkeologiska laboratoriet.
    Pollenanalys av ett prov från ett vattenhål/kallkälla inom Fjelie socken, Raä 54, Lomma kommun, Skåne2018Rapport (Annet vitenskapelig)
  • Skårman, Tina
    et al.
    IVL Swedish Environmental Research Institute.
    Hansson, Katarina
    IVL Swedish Environmental Research Institute.
    Mietala, Johanna
    Statistics Sweden.
    Brorström-Lundén, Eva
    IVL Swedish Environmental Research Institute.
    PRTR and synergies with other multilateral agreements, EU legal acts and EEA reportings2014Rapport (Annet vitenskapelig)
    Abstract [en]

    Swedish Environmental Emissions Data (SMED) has, on behalf of the Swedish Environmental Protection Agency (Swedish EPA) compiled an overview of the multilateral agreements, EU legal acts and EEA reports, which is listed in Table 1, together with identified similarities and differences between these and the UNECE (United Nations Economic Commission for Europe) Protocol on Pollutant Release and Transfer Register, i.e. the PRTR Protocol.

    Relevant general information regarding each agreement has been collected from the Internet and, based on the summarized information, possible synergies with the PRTR protocol have been analyzed.

    The study shows that there are synergies between regulations that are included in the project and the PRTR. Furthermore, the results also show that even though similarities can be identified, each regulation requires different information and is thus unique. In Table 2, identified general synergies are presented, and it can be concluded that the regulations that have most in common with the PRTR protocol are the Minamata Convention and the Industrial Emissions Directive.

  • Gao, Tianle
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap. Chinese Acad Med Sci, Inst Mat Med, Beijing, Peoples R China.
    Ma, Haisha
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Genetisk utvecklingsbiologi.
    Xu, Bo
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
    Bergman, Jessica
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
    Larhammar, Dan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Farmakologi.
    Lagerström, Malin C.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Genetisk utvecklingsbiologi.
    The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch2018Inngår i: Journal of Investigative Dermatology, ISSN 0022-202X, E-ISSN 1523-1747, Vol. 138, nr 11, s. 2405-2411Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Itch is a somatosensory modality that serves to alert an organism to harmful elements removable by scratching, such as parasites and chemical irritants. Recently, ablation or silencing of neuropeptide Y (NPY)-expressing spinal interneurons was reported to selectively enhance mechanical itch, whereas chemical itch was unaffected. We examined the effect of activating the NPY/Y-1 receptor system on scratch behavior in mice. We found that intrathecal administration of the Y-1 agonist [Leu(31), Pro(34)]-NPY (LP-NPY) attenuated itch behavior induced by application of 0.07 g von Frey filament in the nape of the neck compared with saline treatment, indicating that activation of the spinal NPY/Y-1 system dampens mechanical itch. However, intrathecal administration of LP-NPY also attenuated chemically induced scratching provoked by intradermal application of histamine or the mast cell degranulator 48/80 (histaminergic itch), and the latter effect could be reversed by administration of the Y-1 antagonist BIBO3304. Intrathecal application of the native nonselective agonist NPY also attenuated histamine or 48/80-induced scratching. Our analyses emphasize the importance of including additional quantitative parameters to characterize the full spectrum of itch behavior and show that the NPY/Y-1 system dampens both mechanically and chemically induced scratching and hence is shared by the two submodalities of itch.

  • Östman, Sofi
    Umeå universitet, Humanistiska fakulteten, Institutionen för idé- och samhällsstudier, Miljöarkeologiska laboratoriet.
    Makrofossilanalys av fyra prover från kokgropar och nedgrävningar inom Klockarbäcken, Raä Umeå socken 589, Västerbotten2018Rapport (Annet vitenskapelig)
  • Pincini, D.
    et al.
    UCL, London Ctr Nanotechnol, Gower St, London WC1E 6BT, England;UCL, Dept Phys & Astron, Gower St, London WC1E 6BT, England;Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England.
    Fabrizi, F.
    Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England.
    Beutier, G.
    Univ Grenoble Alpes, CNRS, Grenoble INP, SIMaP, F-38000 Grenoble, France.
    Nisbet, G.
    Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England.
    Elnaggar, H.
    Univ Utrecht, Debye Inst Nanomat Sci, Univ Weg 99, NL-3584 CG Utrecht, Netherlands.
    Dmitrienko, V. E.
    AV Shubnikov Inst Crystallog, FSRC Crystallog & Photon RAS, Moscow 119333, Russia.
    Katsnelson, M. , I
    Kvashnin, Yaroslav
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori.
    Lichtenstein, A. , I
    Mazurenko, V. V.
    Ural Fed Univ, Dept Theoret Phys & Appl Math, Mira Str 19, Ekaterinburg 620002, Russia.
    Ovchinnikova, E. N.
    Moscow MV Lomonosov State Univ, Fac Phys, Moscow 119991, Russia.
    Dimitrova, O. , V
    Collins, S. P.
    Diamond Light Source Ltd, Diamond House,Harwell Sci & Innovat Campus, Didcot OX11 0DE, Oxon, England.
    Role of the orbital moment in a series of isostructural weak ferromagnets2018Inngår i: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 98, nr 10, artikkel-id 104424Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The orbital contribution to the magnetic moment of the transition-metal ion in the isostructural weak ferromagnets ACO(3) (A = Mn,Co,Ni) and FeBO3 was investigated by a combination of first-principles calculations, nonresonant x-ray magnetic scattering, and x-ray magnetic circular dichroism. A nontrivial evolution of the orbital moment as a function of the 3d orbitals filling is revealed, with a particularly large value found in the Co member of the family. Here, the coupling between magnetic and lattice degrees of freedom produced by the spin-orbit interaction results in a large single-ion anisotropy and a peculiar magnetic-moment-induced electron cloud distortion, evidenced by the appearance of a subtle scattering amplitude at space-group-forbidden reflections and significant magnetostrictive effects. Our results, which complement a previous investigation on the sign of the Dzyaloshinskii-Moriya interaction across the series, highlight the importance of spin-orbit coupling in the physics of weak ferromagnets and prove the ability of modern first-principles calculations to predict the properties of materials where the Dzyaloshinskii-Moriya interaction is a fundamental ingredient of the magnetic Hamiltonian.

  • Appelgren, Ester
    Södertörns högskola, Institutionen för samhällsvetenskaper, Journalistik.
    Bokrecension: Aske Kammer: Digital journalistik: kort og præcist om medier og kommunikation2018Inngår i: Nordicom Information, ISSN 0349-5949, Vol. 40, nr 2, s. 124-126Artikkel, omtale (Annet vitenskapelig)
  • Sparring, Vibeke
    et al.
    Granström, Emma
    Sachs, Magna Andreen
    Brommels, Mats
    Nyström, Monica E
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa. Department of Learning, Informatics, Management and Ethics, Medical Management Centre, Karolinska Institutet, SE-17177 Stockholm, Sweden.
    One size fits none: a qualitative study investigating nine national quality registries' conditions for use in quality improvement, research and interaction with patients2018Inngår i: BMC Health Services Research, ISSN 1472-6963, E-ISSN 1472-6963, Vol. 18, artikkel-id 802Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Swedish National Quality Registries (NQRs) are observational clinical registries that have long been seen as an underused resource for research and quality improvement (QI) in health care. In recent years, NQRs have also been recognised as an area where patients can be involved, contributing with self-reported experiences and estimations of health effects. This study aimed to investigate what the registry management perceived as barriers and facilitators for the use of NQRs in QI, research, and interaction with patients, and main activities undertaken to enhance their use for these purposes. The aim was further to identify potential differences between various types of NQRs for their use in these areas.

    Methods: In this multiple case study, nine NQRs were purposively selected. Interviews (n = 18) were conducted and analysed iteratively using conventional and directed content analysis.

    Results: A recent national investment initiative enabled more intensive work with development areas previously identified by the NQR management teams. The recent focus on value-based health care and other contemporary national healthcare investments aiming at QI and public benchmarking were perceived as facilitating factors. Having to perform double registrations due to shortcomings in digital systems was perceived as a barrier, as was the lack of authority on behalf of the registry management to request participation in NQRs and QI activities based on registry outcomes. The registry management teams used three strategies to enhance the use of NQRs: ensuring registering of correct and complete data, ensuring updated and understandable information available for patients, clinicians, researchers and others stakeholders, and intensifying cooperation with them. Varied characteristics of the NQRs influenced their use, and the possibility to reach various end-users was connected to the focus area and context of the NQRs.

    Conclusions: The recent national investment initiative contributed to already ongoing work to strengthen the use of NQRs. To further increase the use, the demands of stakeholders and end-users must be in focus, but also an understanding of the NQRs' various characteristics and challenges. The end-users may have in common a need for training in the methodology of registry based research and benchmarking, and how to be more patient-centred.

  • Skårman, Tina
    et al.
    Utförare miljöövervakning, Forskningsinstitut, IVL Svenska Miljöinstitutet AB.
    Hansson, Katarina
    Utförare miljöövervakning, Forskningsinstitut, IVL Svenska Miljöinstitutet AB.
    Mietala, Johanna
    Statistiska centralbyrån (SCB) .
    Brorström-Lundén, Eva
    Utförare miljöövervakning, Forskningsinstitut, IVL Svenska Miljöinstitutet AB.
    PRTR och synergier med andra multilaterala överenskommelser, EU-rättsakter och EEA-rapporteringar2014Rapport (Annet vitenskapelig)
    Abstract [sv]

    Svenska MiljöEmissionsData (SMED) har på uppdrag av Naturvårdsverket (NV) sammanställt övergripande information om de multilaterala överenskommelser, EU-rättsakter och EEA-rapporteringar som listas i Tabell 1, samt identifierat huruvida det finns beröringspunkter respektive avvikelser mellan dessa och UNECE (United Nations Economic Commission for Europe) -protokollet om "Pollutant Release and Transfer Register", dvs. PRTR-protokollet.

    Relevant övergripande information för respektive reglering har sammanställts från Internet och utifrån dessa sammanställningar har eventuella synergier med PRTR-protokollet analyserats.

    Studien visar att det finns synergier mellan de regleringar som inkluderats i projektet och med PRTR. Samtidigt visar studien att även om man kan identifiera beröringspunkter så efterfrågas inte exakt samma information utan samtliga regleringar är unika. I Tabell 2 redovisas identifierade övergripande synergier och man konstatera att de regleringar som PRTR-protokollet har flest antal beröringspunkter med är Minamatakonventionen och Industriutsläppsdirektivet (IED).