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  • Hansson Mild, Kjell
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
    Møllerløkken, Ole Jacob
    Occupational Exposure to Magnetic Field inTranscranial Magnetic Stimulation Treatment2018Inngår i: Transcranial Magnetic Stimulation in Neuropsychiatry / [ed] Ustohal, Libor, IntechOpen , 2018, s. 143-149Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    Transcranial magnetic stimulation (TMS) is used both as a diagnostic instrument and for therapy, available only at some psychiatric clinics for treatment of depression and at clinical neurophysiology where TMS is used for diagnosis of nerve damage. The Swedish National Board of Health and Welfare issued a referral edition about the use of repetitive TMS as an alternative treatment for depression. This may lead to a major increase in the application of TMS to treat depression. TMS is based on induction of an electric (E) field inside the brain by application of an external magnetic field with rapid rise and fall time. The E field in the brain has been calculated when different coils were used for the treatment. The reported E fields are of the order of tens to hundreds of volts per meter and the induced current density is estimated at tens of A/m2. This field can depolarize neurons or modulate cortical excitability by selecting the appropriate parameters for stimulation and the duration of the treatment session. The mechanisms of action of neurostimulation still remain incompletely understood.

  • Disputas: 2019-06-13 10:15 E22, Visby
    Eriksson, Ola
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper.
    Numerical Computations of Wakes Behind Wind Farms: A tool to study Farm to Farm interaction2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    More and larger wind farms are planned offshore. As the most suitable sites to build are limited these new wind farms will be constructed near to each other in so called wind farm clusters. Behind the wind turbines in these farms there is a disrupted flow of air called a wake that is characterized by reduced wind speed and increased turbulence. These individual turbine wakes combine to form a farm wake that can travel long distances. In wind farm clusters farm to farm interaction will occur, i.e. the long distance wake from one wind farm will impact the wind conditions for other farms in the surrounding area.

    This thesis contains numerical studies of these long distance wakes. In these studies Large Eddy Simulations (LES) using an Actuator Disc method (ACD) are used. A prescribed boundary layer is used where the wind shear is introduced using body forces. The turbulence, based on the Mann model, is introduced as fluctuating body forces upstream of the farm. A neutral atmosphere is assumed. The applied method has earlier been used for studies of wake effects inside farms but not for the longer distances needed for the study of farm to farm interaction. Parameter studies are setup to analyze how to best use the model for the study of long distance wakes with regards to 1) numerical and physical parameters in the model, 2) the extension of the domain and turbulence as well as the characteristics of the flow far downstream and 3) the downstream development of turbulence with different combinations of wind shear and turbulence level.

    Using an initial simulation setup a wind farm was studied and preliminary results were obtained. These results were subsequently improved upon by applying the simulation setup adjustments indicated in the parameter studies. A comparison with a mesoscale model was also done. The mesoscale model was shown to be relevant for studies of long distance wakes in another study comparing LES and WRF. Finally an idealized farm to farm interaction case was studied with focus on the impact of including the Coriolis force in the simulations.

    Combining LES with a mesoscale model is of interest to study further.

  • Disputas: 2019-05-17 10:15 Sal IV, Uppsala
    Yadala Suneson, Anita
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen, Kyrko- och missionsstudier.
    Indian Protestants and their Religious Others: Views of Religious Diversity among Christians in Bangalore2019Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    This study gives an in-depth insight into ways that ordinary Christians in a multireligious context think about religious plurality. It examines how Indian Protestants reflect upon other religions and upon the situation of religious diversity.

    Methodologically, the study relies mainly on qualitative interviews with Pentecostal and Church of South India (CSI) lay members and pastors from Bangalore, south India. The interviews are analysed through thematic analysis.

    The study reveals a theological diversity among interviewees. The major differences are found among the clergy, while the views of Pentecostal and CSI lay interviewees show many similarities. The dominant theological perspective is evangelical and this forms an “evangelical lens” that colours attitudes to other religions. Additionally, a general Protestant perspective emerges that reflects a typically Protestant emphasis on Christ and the Bible, as well as a liberal Protestant perspective which focuses on social issues.

    Salvation, primarily understood in terms of eternal life for the individual, is central to the ideas interviewees have about the difference between Protestant Christianity and other religions. Perceptions of Hinduism reveal stereotypical views which portray it as an antithesis to Christian faith. Views of Islam are more positive, and similarities with Protestantism are perceived. Attitudes to different Christian traditions, and to Catholicism in particular, illustrate that the line between religious self and other can be drawn also between different forms of Christianity.

    An important finding of the study is that the use of religious images is a central issue for these Protestant Christians which affects their views of other religions and that it signals religious otherness to them. The dichotomy between religious self and other refers primarily to salvation and religious efficacy, not to everyday life. As people, Muslims and particularly Hindus are portrayed in a positive light. Interreligious friendship and unstressful everyday interaction characterise interviewees’ depictions of relations with religious others in Bangalore. The religious minority status becomes plainly evident in relation to mission. Interviewees negotiate between an ideal of active evangelism and social considerations. This study reveals that it is possible to combine theological exclusivism in theory with respect for the religious other in practice.

  • Alvfors, Per
    et al.
    Energiprocesser, Kungliga Tekniska Högskolan, KTH, Stockholm.
    Ellegård, Kajsa
    Linköpings universitet, Institutionen för tema, Tema teknik och social förändring. Linköpings universitet, Filosofiska fakulteten.
    Harvey, Simon
    Energiteknik/Rymd-, geo- och miljövetenskap, Chalmers Tekniska högskola, Göteborg.
    Karlsson, Magnus
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Moshfegh, Bahram
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Palm, Jenny
    Linköpings universitet, Institutionen för tema, Tema teknik och social förändring. Linköpings universitet, Filosofiska fakulteten.
    Söderström, Mats
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Widén, Joakim
    Institutionen för teknikvetenskaper, Byggteknik, Uppsala universitet.
    Forskarskolan Program Energisystem: Kunskapsutveckling genom samverkanmellan teknik- och samhällsvetenskap: Slutrapport 2016, Publikationer från Program Energisystem2016Rapport (Annet vitenskapelig)
    Abstract [sv]

    Det finns en omfattande publicering från Program Energisystem. Förutom 78 doktorsavhandlingar och 16 licentiatavhandlingar så har forskarstuderande och seniorer publicerat ytterligare minst 500 publikationer inom ramen för Program Energisystem.

    I denna rapport förtecknas dessa publikationer.

  • Alvfors, Per
    et al.
    Energiprocesser, Kungliga Tekniska Högskolan, KTH, Stockholm.
    Ellegård, Kajsa
    Linköpings universitet, Institutionen för tema, Tema teknik och social förändring. Linköpings universitet, Filosofiska fakulteten.
    Harvey, Simon
    Energiteknik/Rymd-, geo- och miljövetenskap, Chalmers Tekniska högskola, Göteborg.
    Karlsson, Magnus
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Moshfegh, Bahram
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Palm, Jenny
    Linköpings universitet, Institutionen för tema, Tema teknik och social förändring. Linköpings universitet, Filosofiska fakulteten.
    Söderström, Mats
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Widén, Joakim
    Institutionen för teknikvetenskaper, Byggteknik, Uppsala universitet.
    Forskarskolan Program Energisystem: Kunskapsutveckling genom samverkanmellan teknik- och samhällsvetenskap: Slutrapport 2016, Forskningssyntes för konsortiet Lokala och regionala energisystem2016Rapport (Annet vitenskapelig)
    Abstract [sv]

    Forskarskolan Program Energisystem har med sina fem deltagande forskningsavdelningar från Chalmers tekniska högskola, Linköpings universitet, KTH och Uppsala universitet varit banbrytande inom tvärvetenskaplig energisystemforskning och dess tre konsortier har spelat en viktig roll för forskarskolans utveckling. Konsortierna är inriktade på byggnader i energisystem, industriella energisystem samt lokala och regionala energisystem. I varje konsortium har doktorander och seniorer från minst två av de deltagande avdelningarna bedrivit tvärvetenskaplig forskning.

    I det lokala och regionala konsortiet har forskningsfrågorna kretsat kring aktörer och processer av betydelse för energisystemen i svenska kommuner, län och regioner. Inom konsortiet har frågeställningar om miljömässigt, socialt och ekonomiskt hållbara lokala och regionala energisystem bland annat studerats genom att analysera aktörers agerande och politiska processer inom de tekniska, ekonomiska och institutionella villkor som utgör begränsningar och möjligheter för energisystemen. En tydlig trend inom konsortiets forskning under forskarskolans arton år är att inriktningen gått i riktning från lokal till regional och från stationära till mobila energisystem. Den förskjutningen följer också den ökande betydelse som regioner i form av länsstyrelser har fått för samordningen av energi- och klimatplaneringen i Sverige under det senaste decenniet. Kommunerna har fortfarande en dominerande position genom den energirelaterade infrastruktur som de förfogar över men en förskjutning mot ett mer regionalt inflytande är tydlig.

    Totalt har 26 doktors- och en licentiatexamen avlagts av konsortiets doktorander och dessa alumner är nu verksamma inom energirelaterade verksamheter Sverige. Den främsta representationen finns inom myndigheter och akademier.

  • Disputas: 2019-05-20 10:15 Humanistiska teatern, Uppsala
    Sundh, Joakim
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    The Cognitive Basis of Joint Probability Judgments: Processes, Ecology, and Adaption2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    When navigating an uncertain world, it is often necessary to judge the probability of a conjunction of events, that is, their joint probability. The subject of this thesis is how people infer joint probabilities from probabilities of individual events. Study I explored such joint probability judgment tasks in conditions with independent events and conditions with systematic risk that could be inferred through feedback. Results indicated that participants tended to approach the tasks using additive combinations of the individual probabilities, but switch to multiplication (or, to a lesser extent, exemplar memory) when events were independent and additive strategies therefore were less accurate. Consequently, participants were initially more accurate in the task with high systematic risk, despite that task being more complex from the perspective of probability theory. Study II simulated the performance of models of joint probability judgment in tasks based both on computer generated data and real-world data-sets, to evaluate which cognitive processes are accurate in which ecological contexts. Models used in Study I and other models inspired by current research were explored. The results confirmed that, by virtue of their robustness, additive models are reasonable general purpose algorithms, although when one is familiar with the task it is preferable to switch to other strategies more specifically adapted to the task. After Study I found that people adapt strategy choice according to dependence between events and Study II confirmed that these adaptions are justified in terms of accuracy, Study III investigated whether adapting to stochastic dependence implied thinking according to stochastic principles. Results indicated that this was not the case, but that participants instead worked according to the weak assumption that events were independent, regardless of the actual state of the world. In conclusion, this thesis demonstrates that people generally do not combine individual probabilities into joint probability judgments in ways consistent with the basic principles of probability theory or think of the task in such terms, but neither does there appear to be much reason to do so. Rather, simpler heuristics can often approximate equally or more accurate judgments.

  • Alvfors, Per
    et al.
    Energiprocesser, Kungliga Tekniska Högskolan, KTH, Stockholm.
    Ellegård, Kajsa
    Linköpings universitet, Institutionen för tema, Tema teknik och social förändring. Linköpings universitet, Filosofiska fakulteten.
    Harvey, Simon
    Energiteknik/Rymd-, geo- och miljövetenskap, Chalmers Tekniska högskola, Göteborg.
    Karlsson, Magnus
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Moshfegh, Bahram
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Palm, Jenny
    Linköpings universitet, Institutionen för tema, Tema teknik och social förändring. Linköpings universitet, Filosofiska fakulteten.
    Söderström, Mats
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Widén, Joakim
    Institutionen för teknikvetenskaper, Byggteknik, Uppsala universitet.
    Forskarskolan Program Energisystem: Kunskapsutveckling genom samverkanmellan teknik- och samhällsvetenskap: Slutrapport 2016, Forskningssyntes för konsortiet Industriella energisystem2016Rapport (Annet vitenskapelig)
    Abstract [sv]

    Denna syntesrapport är en sammanfattning och analys av den forskning som bedrivits inom ramen för det Industriella konsortiet från år 1997 (konsortiets verksamhet startade 1999) inom ramen för forskarskolan Program Energisystem. Under denna tid har 25 doktorsavhandlingar och en licentiatavhandling producerats inom det Industriella konsortiet. Avhandlingarna sammanfattas och analyseras i denna syntesrapport och arbetet avgränsas då till att studera avhandlingarnas Problemområde, Verktyg/Metod/Teori, Systemgräns, studerad Sektor och Övergripande resultat. Vidare ges, med utgångspunkt från dessa forskningsresultat, förslag på fortsatt forskning för hållbara och effektiva energisystem.

    Många viktiga problemområden har studerats inom ramen för forskarskolans Industrikonsortium. Ett flertal avhandlingar behandlar möjligheter att minska utsläppen av växthusgaser från industrin och här har flera sektorer studerats, bland annat massa- och pappersindustrin, järn- och stålindustrin, kemiindustrin och oljeraffinaderiindustrin. Ett centralt tema i avhandlingarna är potentialer för energieffektivisering i industrisektorn, inte minst vid införande av bioraffinaderikoncept i framtiden. Här analyseras t.ex. tekniska potentialer, kostnadseffektivitet för energieffektiviseringsåtgärder, samt betydelsen av energiledning och styrmedel.

    I avhandlingarna har en mängd olika metoder och verktyg använts. Den i särklass mest använda vetenskapliga metoden är intervjuer (15) följt av scenarioanalys (10), dokumentstudier (9), simuleringsberäkningar (9), pinchanalys (9) och optimering (8). Fallstudiemetodik där mer än en metod används för att studera ett specifikt fall, t.ex. ett företag, förekommer i flera avhandlingar. En grundtanke i forskarskolan Program Energisystem har varit att forskaren måste vara medveten om att resultat från energisystemanalyser kan påverkas av vilka systemgränser som valts. I flertalet av Industrikonsortiets avhandlingar har Europas elsystem utgjort systemgräns då effekter av förändrad elanvändning eller elproduktion analyserats.

    Industrikonsortiets forskningsresultat visar på många intressanta slutsatser. Det påvisas att det finns energieffektiviseringspotentialer både i nya investeringar och i energiledningsåtgärder, som att justera driftsbetingelser för befintlig teknisk utrustning och ändra beteenden. Det konstateras också att energisamarbeten mellan industri och energibolag med syfte att öka användningen av industriell överskottsvärme i många fall är en hållbar lösning som minskar regioners behov av primärenergi och reducerar utsläppen av växthusgaser. Hinder mot sådana samarbeten kan vara att detta inte är en del av industrins kärnverksamhet. Det konstateras även att energisamarbeten mellan närliggande anläggningar i ett industrikluster kan leda till avsevärt större energieffektiviseringspotentialer än om var och en av de ingående industrierna arbetar enbart med interna åtgärder. Hinder mot denna typ av samarbete är brist på etablerade affärsmodeller. Forskningen visar på ett behov av fortsatta studier kring begreppet kärnverksamhet och dess påverkan på energifrågan i svensk industrin. Avskiljning och lagring av koldioxid (CCS) från industrin har studerats och här konstateras att denna lösning inte är ekonomiskt lönsam med dagens förutsättningar. Det rekommenderas därför att framtida forskning bedrivs för att studera vilka styrmedel som skulle behövas för att CCS ska bli ekonomiskt intressant för industrin. En annan viktig fråga är hur energitjänsteföretag ska formulera affärsmodeller och strategier kring CCS, samt hur de kan samarbeta med industrin för att på affärsmässiga grunder få till stånd CO2– avskiljning, transport och lagring. Även framtida forskning kring styrmedel, t.ex. energitjänster, för ökad energieffektivitet i industrisektorn förordas. Resultat från Industrikonsortiets avhandlingar visar att processintegrationsverktyget pinchanalys kan kombineras med optimeringsverktyg (i detta fall MIND) vid analys av industriella energisystem. Denna metodkombination ger intressanta resultat varför fortsatt forskning förordas kring kombinationer av olika processintegrationsmetoder. I flertalet avhandlingar har företagsdata använts som indata vid exempelvis modellering och processintegrationsstudier. Detta har accentuerat behovet av ett standardiserat protokoll vid insamling av företagsdata. Ett sådant protokoll kan öka reliabiliteten på indata och förslagsvis användas vid fallstudier.

    Avslutningsvis kan konstateras att trots närmare 20 års tvärvetenskaplig forskning mellan samhällsvetare och teknikvetenskaperna finns det fortfarande mycket mer att beforska och utveckla.

  • Alvfors, Per
    et al.
    Energiprocesser, Kungliga Tekniska Högskolan, KTH, Stockholm.
    Ellegård, Kajsa
    Linköpings universitet, Institutionen för tema, Tema teknik och social förändring. Linköpings universitet, Filosofiska fakulteten.
    Harvey, Simon
    Energiteknik/Rymd-, geo- och miljövetenskap, Chalmers Tekniska högskola, Göteborg.
    Karlsson, Magnus
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Moshfegh, Bahram
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Palm, Jenny
    Linköpings universitet, Institutionen för tema, Tema teknik och social förändring. Linköpings universitet, Filosofiska fakulteten.
    Söderström, Mats
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Widén, Joakim
    Institutionen för teknikvetenskaper, Byggteknik, Uppsala universitet.
    Forskarskolan Program Energisystem: Kunskapsutveckling genom samverkanmellan teknik- och samhällsvetenskap: Slutrapport 2016, Forskningssyntes för konsortiet Byggnader i energisystem2016Rapport (Annet vitenskapelig)
    Abstract [sv]

    Denna rapport ger en kortfattad översikt och syntes av tvärvetenskapliga forskningsresultat från verksamheten i konsortiet Byggnader i energisystem inom forskarskolan Program Energisystem. Tonvikten ligger på tiden från forskarskolans start 1997 till dess 15-årsjubileum 2012, men hänvisningar görs även till forskning publicerad därefter. Utgångspunkten har varit att lyfta fram det tvärvetenskapliga inom forskningen för att visa hur forskarskolan har bidragit till tvärvetenskaplig kunskaps- och metodutveckling.

    I rapporten ges en översikt över fallstudier och avhandlingar inom konsortiet och de tvärvetenskapliga forskningsresultaten sammanfattas inom tre huvudsakliga tematiska områden: (1) Passivhus: boende och energieffektiva byggnadstekniker,

    (2) Energieffektivisering: processer och aktörer, samt (3) Energianvändning, vardagsaktiviteter och småskalig solenergi i hushåll. Tvärvetenskapliga metoder och resultat sammanfattas och utvecklingen av samarbeten och angreppssätt beskrivs. Rapporten avslutas med några sammanfattande reflektioner kring hur framgångsrik tvärvetenskaplig forskning bör bedrivas.

  • Alvfors, Per
    et al.
    Energiprocesser, Kungliga Tekniska Högskolan, KTH, Stockholm.
    Ellegård, Kajsa
    Linköpings universitet, Institutionen för tema, Tema teknik och social förändring. Linköpings universitet, Filosofiska fakulteten.
    Harvey, Simon
    Energiteknik/Rymd-, geo- och miljövetenskap, Chalmers Tekniska högskola, Göteborg.
    Karlsson, Magnus
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Moshfegh, Bahram
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Palm, Jenny
    Linköpings universitet, Institutionen för tema, Tema teknik och social förändring. Linköpings universitet, Filosofiska fakulteten.
    Söderström, Mats
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Energisystem. Linköpings universitet, Tekniska fakulteten.
    Widén, Joakim
    Institutionen för teknikvetenskaper, Byggteknik, Uppsala universitet.
    Forskarskolan Program Energisystem: Kunskapsutveckling genom samverkanmellan teknik- och samhällsvetenskap: Slutrapport 2016, Huvudrapport2016Rapport (Annet vitenskapelig)
    Abstract [sv]

    Idén att samhällsvetenskaplig och teknisk energisystemforskning måste vävas samman för att utveckla ny kunskap och få ökad samhällsnytta var utgångspunkt när Program Energisystem startade år 1997.

    Program Energisystem identifierade tidigt kärnvärden som visades vara viktiga framgångsfaktorer:

    • Energisystem med tyngdpunkt på användarsidan
    • Tvärvetenskaplig, universitets- och fakultetsöverskridande
    • forskning och forskarutbildning
    • Sammanhållen forskarskola
    • Finansiering av hela doktorandprojekt
    • Samarbeten i tematiska forskningsområden
    • Kontinuerlig tvärvetenskaplig utveckling
    • Långsiktig finansiering av samordningsstruktur

    Program Energisystems arbete har kännetecknats av:

    • Val av samhällsrelevanta projekt av hög vetenskaplig kvalitet
    • Gemensamma tvärvetenskapliga kurser och projektarbeten
    • Tvärvetenskaplig handledning
    • Kontinuerligt arbetande fora för diskussion
    • och kontakter över ämnesgränser
    • Forskningssamarbeten mellan seniorer i olika ämnen
    • Aktivt doktorand- och alumninätverk

    Forskarutbildningens målsättning har varit att utbilda bättre samhällsvetare

    och bättre ingenjörer, inte att göra samhällsvetare av ingenjörerna eller ingenjörer

    av samhällsvetarna.

    I den kontinuerliga utvecklingen av Program Energisystem har ett förtroendefullt samarbete utvecklats som möjliggjort kontinuerliga förbättringar av forskningen och forskarutbildningen.

    Arvet från Program Energisystem har förts vidare i den nya Forskarskola Energisystem. Forskarskola Energisystem har en delvis annan struktur men bygger innehållsmässigt vidare på centrala idéer från Program Energisystem. Det finns ett fortsatt stort behov av tvärvetenskaplig kunskapsutveckling på energiområdet som främst handlar om att förstå komplicerade samband och processer och hur dessa kan påverkas.

  • Elmstedt, Sixten
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Mogensen, Hanna
    Karolinska Inst, Inst Environm Med, Unit Epidemiol, Stockholm, Sweden.
    Hallmans, Dan-Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Tavelin, Björn
    Umea Univ, Dept Radiat Sci, Umea, Sweden.
    Lundström, Staffan
    Karolinska Inst, Stockholms Sjukhem Fdn, Stockholm, Sweden;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
    Lindskog, Magnus
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Cancer patients hospitalised in the last week of life risk insufficient care quality - a population-based study from the Swedish Register of Palliative Care2019Inngår i: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 58, nr 4, s. 432-438Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: One-quarter of all cancer deaths in Sweden occur in hospitals. If the place of death affects the quality of end-of-life (EOL) is largely unknown.

    Methods: This population-based, retrospective study included all adults cancer deaths reported to the Swedish Register of Palliative Care in 2011-2013 (N = 41,729). Hospital deaths were compared to deaths occurring in general or specialised palliative care, or in nursing homes with respect to care quality indicators in the last week of life. Odds ratios (OR) with 95% confidence intervals (CI) were calculated with specialised palliative home care as reference.

    Results: Preferred place of death was unknown for 63% of hospitalised patients and consistent with the actual place of death in 25% compared to 97% in palliative home care. Hospitalised patients were less likely to be informed when death was imminent (OR: 0.3; CI: 0.28-0.33) as were their families (OR: 0.51; CI: 0.46-0.57). Validated screening tools were less often used in hospitals for assessment of pain (OR: 0.32; CI: 0.30-0.34) or other symptoms (OR: 0.31; CI: 0.28-0.34) despite similar levels of EOL symptoms. Prescriptions of as needed drugs against anxiety (OR: 0.27; CI: 0.24-0.30), nausea (OR: 0.19; CI: 0.17-0.21), or pulmonary secretions (OR: 0.29; CI: 0.26-0.32) were less prevalent in hospitals. Bereavement support was offered after 57% of hospital deaths compared to 87-97% in palliative care units and 72% in nursing homes.

    Conclusions: Dying in hospital was associated with inferior end-of-life care quality among cancer patients in Sweden.

  • Zhu, Yanping
    et al.
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Qi, Xiaoying
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Yu, Cuicui
    Qing Dao Univ, Affiliated Yantai Yuhuangding Hosp, Dept Anesthesiol, 20 Yudong Rd, Yantai S264009, Shandong, Peoples R China.
    Yu, Shoujun
    Binzhou Med Univ, Yantai Affiliated Hosp, Dept Ultrasound, 717 Jinfu Rd, Binzhou 264100, Shandong, Peoples R China.
    Zhang, Chao
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Zhang, Yuan
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Liu, Xiuxiu
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Xu, Yuxue
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Yang, Chunhua
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Jiang, Wenguo
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Tian, Geng
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Li, Xuri
    Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China.
    Bergquist, Jonas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi. Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Zhang, Jiandi
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China;Yantai Zestern Biotech Co LTD, 39 Keji Ave Bioasis, Yantai, Peoples R China.
    Wang, Lei
    Harbin Med Univ, Affiliated Hosp 1, Dept Thorac Surg, 23 Youzheng St, Harbin 150000, Heilongjiang, Peoples R China.
    Mi, Jia
    Binzhou Med Univ, Precis Med Res Ctr, 346 Guanhai Rd, Yantai 264003, Shandong, Peoples R China.
    Identification of prothymosin alpha (PTMA) as a biomarker for esophageal squamous cell carcinoma (ESCC) by label-free quantitative proteomics and Quantitative Dot Blot (QDB)2019Inngår i: Clinical Proteomics, ISSN 1542-6416, E-ISSN 1559-0275, Vol. 16, artikkel-id 12Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Esophageal cancer (EC) is one of the malignant tumors with a poor prognosis. The early stage of EC is asymptomatic, so identification of cancer biomarkers is important for early detection and clinical practice.

    Methods: In this study, we compared the protein expression profiles in esophageal squamous cell carcinoma (ESCC) tissues and adjacent normal esophageal tissues from five patients through high-resolution label-free mass spectrometry. Through bioinformatics analysis, we found the differentially expressed proteins of ESCC. To perform the rapid identification of biomarkers, we adopted a high-throughput protein identification technique of Quantitative Dot Blot (QDB). Meanwhile, the QDB results were verified by classical immunohistochemistry.

    Results: In total 2297 proteins were identified, out of which 308 proteins were differentially expressed between ESCC tissues and normal tissues. By bioinformatics analysis, the four up-regulated proteins (PTMA, PAK2, PPP1CA, HMGB2) and the five down-regulated proteins (Caveolin, Integrin beta-1, Collagen alpha-2(VI), Leiomodin-1 and Vinculin) were selected and validated in ESCC by Western Blot. Furthermore, we performed the QDB and IHC analysis in 64 patients and 117 patients, respectively. The PTMA expression was up-regulated gradually along the progression of ESCC, and the PTMA expression ratio between tumor and adjacent normal tissue was significantly increased along with the progression. Therefore, we suggest that PTMA might be a potential candidate biomarker for ESCC.

    Conclusion: In this study, label-free quantitative proteomics combined with QDB revealed that PTMA expression was up-regulated in ESCC tissues, and PTMA might be a potential candidate for ESCC. Since Western Blot cannot achieve rapid and high-throughput screening of mass spectrometry results, the emergence of QDB meets this demand and provides an effective method for the identification of biomarkers.

  • Wang, Kun
    et al.
    Stockholm Univ, Dept Mol Biosci, Wenner Gren Inst, Svante Arrhenius V 20C, SE-10691 Stockholm, Sweden.
    Sybers, David
    Vrije Univ Brussel, Dept Bioengn Sci, Res Grp Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.
    Maklad, Hassan Ramadan
    Vrije Univ Brussel, Dept Bioengn Sci, Res Grp Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.
    Lemmens, Liesbeth
    Vrije Univ Brussel, Dept Bioengn Sci, Res Grp Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.
    Lewyllie, Charlotte
    Vrije Univ Brussel, Dept Bioengn Sci, Res Grp Microbiol, Pl Laan 2, B-1050 Brussels, Belgium;Vrije Univ Brussel, Dept Biol, Lab Cell Genet, Pl Laan 2, B-1050 Brussels, Belgium.
    Zhou, Xiaoxiao
    Univ Duisburg Essen, Mol Enzymtechnol & Biochem, Biofilm Ctr, ZWU,Fak Chem, Univ Str 2, D-45117 Essen, Germany.
    Schult, Frank
    Univ Duisburg Essen, Mol Enzymtechnol & Biochem, Biofilm Ctr, ZWU,Fak Chem, Univ Str 2, D-45117 Essen, Germany.
    Bräsen, Christopher
    Univ Duisburg Essen, Mol Enzymtechnol & Biochem, Biofilm Ctr, ZWU,Fak Chem, Univ Str 2, D-45117 Essen, Germany.
    Siebers, Bettina
    Univ Duisburg Essen, Mol Enzymtechnol & Biochem, Biofilm Ctr, ZWU,Fak Chem, Univ Str 2, D-45117 Essen, Germany.
    Valegård, Karin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Lindås, Ann-Christin
    Stockholm Univ, Dept Mol Biosci, Wenner Gren Inst, Svante Arrhenius V 20C, SE-10691 Stockholm, Sweden.
    Peeters, Eveline
    Vrije Univ Brussel, Dept Bioengn Sci, Res Grp Microbiol, Pl Laan 2, B-1050 Brussels, Belgium.
    A TetR-family transcription factor regulates fatty acid metabolism in the archaeal model organism Sulfolobus acidocaldarius2019Inngår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, artikkel-id 1542Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Fatty acid metabolism and its regulation are known to play important roles in bacteria and eukaryotes. By contrast, although certain archaea appear to metabolize fatty acids, the regulation of the underlying pathways in these organisms remains unclear. Here, we show that a TetR-family transcriptional regulator (FadR(sa)) is involved in regulation of fatty acid metabolism in the crenarchaeon Sulfolobus acidocaldarius. Functional and structural analyses show that FadR(sa) binds to DNA at semi-palindromic recognition sites in two distinct stoichiometric binding modes depending on the operator sequence. Genome-wide transcriptomic and chromatin immunoprecipitation analyses demonstrate that the protein binds to only four genomic sites, acting as a repressor of a 30-kb gene cluster comprising 23 open reading frames encoding lipases and beta-oxidation enzymes. Fatty acyl-CoA molecules cause dissociation of FadR(sa) binding by inducing conformational changes in the protein. Our results indicate that, despite its similarity in overall structure to bacterial TetR-family FadR regulators, FadR(sa) displays a different acyl-CoA binding mode and a distinct regulatory mechanism.

  • Disputas: 2019-05-28 14:00 Sal B, Kista
    Vasiloudis, Theodore
    KTH, Skolan för elektroteknik och datavetenskap (EECS), Beräkningsvetenskap och beräkningsteknik (CST). RISE.
    Scalable Machine Learning through Approximation and Distributed Computing2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Machine learning algorithms are now being deployed in practically all areas of our lives. Part of this success can be attributed to the ability to learn complex representations from massive datasets. However, computational speed increases have not kept up with the increase in the sizes of data we want to learn from, leading naturally to algorithms that need to be resource-efficient and parallel. As the proliferation of machine learning continues, the ability for algorithms to adapt to a changing environment and deal with uncertainty becomes increasingly important.

    In this thesis we develop scalable machine learning algorithms, with a focus on efficient, online, and distributed computation. We make use of approximations to dramatically reduce the computational cost of exact algorithms, and develop online learning algorithms to deal with a constantly changing environment under a tight computational budget. We design parallel and distributed algorithms to ensure that our methods can scale to massive datasets.

    We first propose a scalable algorithm for graph vertex similarity calculation and concept discovery. We demonstrate its applicability to multiple domains, including text, music, and images, and demonstrate its scalability by training on one of the largest text corpora available. Then, motivated by a real-world use case of predicting the session length in media streaming, we propose improvements to several aspects of learning with decision trees. We propose two algorithms to estimate the uncertainty in the predictions of online random forests. We show that our approach can achieve better accuracy than the state of the art while being an order of magnitude faster. We then propose a parallel and distributed online tree boosting algorithm that maintains the correctness guarantees of serial algorithms while providing an order of magnitude speedup on average. Finally, we propose an algorithm that allows for gradient boosted trees training to be distributed across both the data point and feature dimensions. We show that we can achieve communication savings of several orders of magnitude for sparse datasets, compared to existing approaches that can only distribute the computation across the data point dimension and use dense communication.

  • Jespers, Willem
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Beräkningsbiologi och bioinformatik.
    Esguerra, Mauricio
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Beräkningsbiologi och bioinformatik.
    Åqvist, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Beräkningsbiologi och bioinformatik.
    Gutiérrez-de-Terán, Hugo
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Beräkningsbiologi och bioinformatik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    QligFEP: an automated workflow for small molecule free energy calculations in Q2019Inngår i: Journal of Cheminformatics, ISSN 1758-2946, E-ISSN 1758-2946, Vol. 11, artikkel-id 26Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The process of ligand binding to a biological target can be represented as the equilibrium between the relevant solvated and bound states of the ligand. This which is the basis of structure-based, rigorous methods such as the estimation of relative binding affinities by free energy perturbation (FEP). Despite the growing capacity of computing power and the development of more accurate force fields, a high throughput application of FEP is currently hampered due to the need, in the current schemes, of an expert user definition of the alchemical transformations between molecules in the series explored. Here, we present QligFEP, a solution to this problem using an automated workflow for FEP calculations based on a dual topology approach. In this scheme, the starting poses of each of the two ligands, for which the relative affinity is to be calculated, are explicitly present in the MD simulations associated with the (dual topology) FEP transformation, making the perturbation pathway between the two ligands univocal. We show that this generalized method can be applied to accurately estimate solvation free energies for amino acid sidechain mimics, as well as the binding affinity shifts due to the chemical changes typical of lead optimization processes. This is illustrated in a number of protein systems extracted from other FEP studies in the literature: inhibitors of CDK2 kinase and a series of A(2A) adenosine G protein-coupled receptor antagonists, where the results obtained with QligFEP are in excellent agreement with experimental data. In addition, our protocol allows for scaffold hopping perturbations to identify the binding affinities between different core scaffolds, which we illustrate with a series of Chk1 kinase inhibitors. QligFEP is implemented in the open-source MD package Q, and works with the most common family of force fields: OPLS, CHARMM and AMBER.

  • Disputas: 2019-05-23 10:00 Magnélisalen, Kemiska övningslaboratoriet, Stockholm
    Pettersson, Pontus
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Structure, dynamics and lipid interaction of membrane-associated proteins2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    A research topic within the field of molecular biophysics is the structure-function relationship of proteins. Membrane proteins are a large, diverse group of biological macromolecules that perform many different and essential functions for the cell. Despite the abundance and importance of membrane proteins, high-resolution 3D structures from this class of proteins are underrepresented among all yet determined structures. The limited amount of data for membrane proteins hints about the higher difficulty associated with studies of this group of molecules. The determination of an atomic resolution structure is often a long process in which several obstacles need to be overcome, in particular for membrane proteins.

    Solution-state nuclear magnetic resonance (NMR) is a powerful measurement technique that can provide high-resolution data on the structure and dynamics of biological macromolecules, and is suitable for studies of small, dynamic membrane proteins. However, even with solution-state NMR, the membrane proteins need to be investigated in environments that are sometimes severely compromising for the protein’s native structure and function. In order to evaluate the biological significance of results obtained under such artificial conditions, supporting data from experiments in more realistic membrane models, obtained using NMR and other biophysical methods, is of great importance.

    The work presented in this thesis concerns studies of four membrane proteins: WaaG, Rcf1, Rcf2 and TatA. These proteins have very different characteristics in terms of their sizes and expected membrane interactions, and were accordingly found to be differently affected by the model membranes in which they were studied. Our results illustrate both the current possibilities and limitations of solution-state NMR for studying membrane proteins, and highlight the benefits of an approach where several membrane mimicking systems and measurements techniques are used in combination to arrive at correct conclusions on the properties of proteins.

  • Disputas: 2019-05-23 10:00 De Geersalen, Geovetenskapens hus, Stockholm
    Bender, Hagen
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för geologiska vetenskaper.
    Assembly of the Caledonian Orogenic Wedge, Jämtland, Sweden2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Collisional orogeny creates the largest mountain belts on Earth. The Caledonides of Scandinavia are a deeply eroded, ancient mountain belt, which today exposes a deep section through the former orogenic interior. The orogenic internides hold important geological information necessary to understand the geodynamic processes shaping collisional plate boundaries. This thesis explores the kinematics and timing of orogenic wedge formation in Jämtland, central Sweden. An integrated approach of structural field mapping, microstructural analysis, Rb–Sr radiogenic dating and rock magnetism yielded new and comprehensive tectonochronologic data. A regionally extensive network of kinematic field data demonstrated pervasive ductile top-to-the-ESE shearing across the entire tectonostratigraphy. Rb–Sr multi-mineral isochron ages constrained the absolute timing of ductile deformation to c. 430 Ma and c. 415 Ma. Local structural and magnetic data showed that final nappe emplacement and exhumation had occurred before extensional deformation initiated. The new data presented in this thesis contradicted a tectonic model previously proposed for Caledonian nappe stacking. These findings were used to develop an alternative tectonic model consistent with both the new and other available structural, petrological and chronological data. The new model for orogenic wedge assembly comprises three stages of foreland-directed, top-to-the-ESE thrusting. It reflects the complex interactions caused by the merging of two subduction zones accommodating Baltica–arc–Laurentia collisions during Ordovician to Devonian time.

  • Disputas: 2019-06-04 09:00 room 132:028, Nordita East Building, Stockholm
    Fathi, Pantea
    Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum.
    Synthesis of complex organics via molecular growth mechanisms: Combined experimental and theoretical studies on ion-neutral reactions of C2H2N+ with ubiquitous hydrocarbons in Titan's ionosphere2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    To provide insights on the molecular growth mechanisms leading to large carbon and nitrogen-bearing species in Titan’s ionosphere, laboratory measurements of ion-neutral reactions were conducted and the results are presented in the following doctoral dissertation. The product ions of the C2H2N+ reactions with saturated and unsaturated neutral hydrocarbons have been investigated using Guided Ion Beam Mass Spectrometer (GIB-MS). The data have been used to reveal the dependence of product ion intensity on pressure and also with respect to collision energy variations to derive useful insights on the nature of chemical reactions leading to the observed species. Complementary theoretical calculations have been also carried out to assist in interpretation of these measurements and to elucidate the reaction schemes. This study provides comprehensive insights on the formation of long chain and heavy carbon-nitrogen bearing species through exothermic and barrierless ion-neutral reactions which are likely to play a significant role in the formation routes of heavy positive ions of interest, which have been detected in Titan’s ionosphere by Cassini’s Ion Neutral Mass Spectrometer (INMS).

  • Buder, S.
    et al.
    MPIA, Koenigstuhl 17, D-69117 Heidelberg, Germany;Heidelberg Univ, Int Max Planck Res Sch Astron & Cosm Phys, Heidelberg, Germany.
    Lind, Karin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Observationell astrofysik. MPIA, Koenigstuhl 17, D-69117 Heidelberg, Germany.
    Ness, M. K.
    Columbia Univ, Dept Astron, Pupin Phys Labs, New York, NY 10027 USA;Flatiron Inst, Ctr Computat Astrophys, 162 Fifth Ave, New York, NY 10010 USA.
    Asplund, M.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia;Ctr Excellence Astrophys Three Dimens ASTRO 3D, Sydney, NSW, Australia.
    Duong, L.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia.
    Lin, J.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia.
    Kos, J.
    Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia;Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia.
    Casagrande, L.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia.
    Casey, A. R.
    Monash Univ, Sch Phys & Astron, Melbourne, Vic, Australia;Monash Univ, Fac Informat Technol, Melbourne, Vic, Australia.
    Bland-Hawthorn, J.
    Ctr Excellence Astrophys Three Dimens ASTRO 3D, Sydney, NSW, Australia;Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia;Univ Calif Berkeley, Miller Inst, Berkeley, CA 94720 USA.
    De Silva, G. M.
    Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia;Macquarie Univ, Dept Phys & Astron, Sydney, NSW 2109, Australia.
    D'Orazi, V
    Osserv Astron Padova, Ist Nazl Astrofis, Vicolo Osservatorio 5, I-35122 Padua, Italy.
    Freeman, K. C.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia.
    Martell, S. L.
    Ctr Excellence Astrophys Three Dimens ASTRO 3D, Sydney, NSW, Australia;Univ New South Wales, Sch Phys, Sydney, NSW 2052, Australia.
    Schlesinger, K. J.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia.
    Sharma, S.
    Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia.
    Simpson, J. D.
    Univ New South Wales, Sch Phys, Sydney, NSW 2052, Australia.
    Zucker, D. B.
    Macquarie Univ, Dept Phys & Astron, Sydney, NSW 2109, Australia.
    Zwitter, T.
    Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia.
    Cotar, K.
    Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia.
    Dotter, A.
    Harvard Smithsonian Ctr Astrophys, Cambridge, MA 02138 USA.
    Hayden, M. R.
    Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia.
    Hyde, E. A.
    Western Sydney Univ, Locked Bag 1797, Penrith, NSW 2751, Australia.
    Kafle, P. R.
    Univ Western Australia, ICRAR, 35 Stirling Highway, Crawley, WA 6009, Australia.
    Lewis, G. F.
    Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia.
    Nataf, D. M.
    Johns Hopkins Univ, Dept Phys & Astron, Baltimore, MD 21218 USA.
    Nordlander, T.
    Australian Natl Univ, Res Sch Astron & Astrophys, Mt Stromlo Observ, Weston, ACT 2611, Australia;Ctr Excellence Astrophys Three Dimens ASTRO 3D, Sydney, NSW, Australia.
    Reid, W.
    Macquarie Univ, Dept Phys & Astron, Sydney, NSW 2109, Australia;Western Sydney Univ, Locked Bag 1797, Penrith, NSW 2751, Australia.
    Rix, H-W
    MPIA, Koenigstuhl 17, D-69117 Heidelberg, Germany.
    Skuladottir, A.
    MPIA, Koenigstuhl 17, D-69117 Heidelberg, Germany.
    Stello, D.
    Univ Sydney, Sch Phys, A28, Sydney Inst Astron SIfA, Sydney, NSW 2006, Australia;Univ New South Wales, Sch Phys, Sydney, NSW 2052, Australia;Aarhus Univ, Stellar Astrophys Ctr, Dept Phys & Astron, DK-8000 Aarhus C, Denmark.
    Ting, Y-S
    Inst Adv Study, Olden Lane, Princeton, NJ 08540 USA;Princeton Univ, Dept Astrophys Sci, Princeton, NJ 08544 USA;Observ Carnegie Inst Washington, 813 Santa Barbara St, Pasadena, CA 91101 USA.
    Traven, G.
    Univ Ljubljana, Fac Math & Phys, Jadranska 19, Ljubljana 1000, Slovenia.
    Wyse, R. F. G.
    Johns Hopkins Univ, Dept Phys & Astron, Baltimore, MD 21218 USA.
    The GALAH survey: An abundance, age, and kinematic inventory of the solar neighbourhood made with TGAS2019Inngår i: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 624, artikkel-id A19Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The overlap between the spectroscopic Galactic Archaeology with HERMES (GALAH) survey and Gaia provides a high-dimensional chemodynamical space of unprecedented size. We present a first analysis of a subset of this overlap, of 7066 dwarf, turn-off, and subgiant stars. These stars have spectra from the GALAH survey and high parallax precision from the Gaia DR1 Tycho-Gaia Astrometric Solution. We investigate correlations between chemical compositions, ages, and kinematics for this sample. Stellar parameters and elemental abundances are derived from the GALAH spectra with the spectral synthesis code SPECTROSCOPY MADE EASY. We determine kinematics and dynamics, including action angles, from the Gaia astrometry and GALAH radial velocities. Stellar masses and ages are determined with Bayesian isochrone matching, using our derived stellar parameters and absolute magnitudes. We report measurements of Li, C, O, Na, Mg, Al, Si, K, Ca, Sc, Ti, V, Cr, Mn, Co, Ni, Cu, Zn, Y, as well as Ba and we note that we have employed non-LTE calculations for Li, O, Al, and Fe. We show that the use of astrometric and photometric data improves the accuracy of the derived spectroscopic parameters, especially log g. Focusing our investigation on the correlations between stellar age, iron abundance [Fe/H], and mean alpha-enhancement [alpha/Fe] of the magnitude-selected sample, we recover the result that stars of the high-a sequence are typically older than stars in the low-a sequence, the latter spanning iron abundances of -0.7 < [Fe/H] < +0.5. While these two sequences become indistinguishable in [alpha/Fe] vs. [Fe/H] at the metal-rich regime, we find that age can be used to separate stars from the extended high-a and the low-a sequence even in this regime. When dissecting the sample by stellar age, we find that the old stars (>8 Gyr) have lower angular momenta L-z than the Sun, which implies that they are on eccentric orbits and originate from the inner disc. Contrary to some previous smaller scale studies we find a continuous evolution in the high-alpha-sequence up to super-solar [Fe/H] rather than a gap, which has been interpreted as a separate "high-alpha metal-rich" population. Stars in our sample that are younger than 10 Gyr, are mainly found on the low alpha-sequence and show a gradient in L-z from low [Fe/H] > (L-z > L-z,L-circle dot) towards higher [Fe/H] (L-z < L-z,L-circle dot), which implies that the stars at the ends of this sequence are likely not originating from the close solar vicinity.

  • Disputas: 2019-05-17 13:00 Hörsal B, Unod T9, Umeå
    Asplund, Pär
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Percutaneous Balloon Compression for the Treatment of Trigeminal Neuralgia2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Background. Trigeminal neuralgia (TN) is a paroxysmal unilateral facial pain condition. That it is rather rare is of little comfort to those who are affected, as TN is often described as one of the worst pains known to mankind. Advanced age and multiple sclerosis (MS) are risk factors for developing TN. The first line of treatment is medical, primarily with carbamazepine. When medical treatment fails, as it does in many patients, there are several surgical options. One of the minimally invasive options, suitable for patients with comorbidity, is percutaneous balloon compression (PBC). Despite its introduction in the early 1980s, PBC is arguably the least well studied of the minimally invasive procedures for the treatment of TN.

    Aims. The aim of this thesis was to evaluate the efficacy of PBC, both overall and in MS-TN patients specifically. Further, it intended to identify and evaluate pre- and intraoperative parameters associated with the efficacy of PBC. It also investigated changes in sensory function after PBC, and identified side effects and complications associated with PBC. Finally, it sought to evaluate how efficacy, side effects and complications differed between PBC and another minimally invasive technique; percutaneous retrogasserian glycerol rhizotomy (PRGR).

    Methods. Cohorts of patients treated with PBC in Umeå and Stockholm, and with PRGR in Umeå, were followed retrospectively. Data from an existing database was combined with data from medical records, radiographs and telephone interviews.

    Results. After PBC, 90 % of the patients were completely pain free without medication for TN. The median time to recurrence of pain was 28 months. In patients with concurrent MS, the initial success rate was 67 % and the median time to recurrence was 8 months. In patients without MS, who had not previously been treated surgically, the initial success rate was 91 % and the median time to recurrence was 48 months. The procedure could, however, be repeated with good results. A good compression, indicated by a pear-shaped balloon as seen on intraoperative lateral radiograph, was crucial to achieve good pain relief. Postoperative hypoesthesia was present in the majority of patients, but after 3-6 months, sensibility was partly or fully normalized in most patients. Severe complications were rare, but included transient cardiac arrest, meningitis and dysesthesia. The side effects profile was favorable to that of percutaneous retrogasserian glycerol rhizotomy, in that the latter produced more cases of dysesthesia and decreased corneal sensibility. The efficacy of the two treatments were, however, not significantly different.

    Conclusions. PBC is an effective and relatively safe treatment option for patients with TN refractory to medical treatment. It deserves its place among the standard treatments for TN, and could be considered for those patients eligible for surgery for which open surgery is a less suitable option.

     

  • Disputas: 2019-05-17 10:15 Hörsal S205, Umeå
    Mackay, Heather
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för geografi.
    Food, farming and health in Ugandan secondary cities2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    This research contributes to countering a large city research bias by focusing on the food, farming and health experiences of two secondary cities of Uganda: Mbale and Mbarara. It is not an apocalyptic story. Like anywhere in the world, for some residents things were going well; for others, less well. My research explores the varied geometries of advantage and disadvantage in diets, food security, and livelihood circumstances to shed light on why things were more secure for some than for others. I used multiple methods including a household survey, focus groups with local healthcare professionals, and in-depth interviews with varied city residents. A geographic perspective explored intersections of food, farming and health with aspects of identity (such as gender, class, tribe), and with place (the city itself, but also with rural areas, or other urban areas).

    The starting point was the theorised food system, nutritional and epidemiologic transitions predicted to occur with urban development, often called nutrition transition theory. My research suggests caution with dominant models of how urban life shifts food and farming systems towards a food system and diet pattern focused around large retailer supermarkets, processed foods, fast foods, more meat, less agriculture, less movement. Nutrition transition theory postulates these changes causing a shift in epidemiology from infectious to non-infectious diseases in urban areas. Instead of the suggestion from nutrition transition theory, my work presents evidence of non-communicable disease (obesity, diabetes, hypertension) experience in Mbale and Mbarara’s residents, but without evidence of advanced change in food and farming systems. Findings revealed relatively low dietary diversities and common food insecurity. Diets remained predominantly traditional, as did the main food sources (traditional markets and neighbourhood shops), across diverse residents. The more food secure had regular salaried employment and strong relational links with rural farms and family, supporting work on multi-spatial livelihoods. This contrasts with earlier ideas of who farms the African city, or retains farming livelihoods. Most vulnerable to food insecurity and low diet diversity were those who were most dependent on purchasing all their food. In conclusion, this research suggests that food system, nutritional and epidemiologic transitions in Mbale and Mbarara may be less linked than previously thought, or linked in more complex ways. Other drivers of epidemiologic change are likely. Findings highlight the importance of local data and specific city investigations.

     

  • Hernes, Vilde
    et al.
    Arendt, Jacob Nielsen
    Joona, Pernilla Andersson
    Tronstad, Kristian Rose
    Nordic integration and settlement policies for refugees: A comparative analysis of labour market integration outcomes2019Bok (Annet vitenskapelig)
    Abstract [en]

    This report has been commissioned by the Labour Market Committee of the Nordic Council of Ministers. The chief aim is to provide policy-relevant knowledge by conducting a comparative analysis of refugee labour-market integration in Scandinavia. Instead of focusing on the well-known employment gap or the fiscal impact of refugee unemployment, this study investigates the divergent impacts of integration programmes and settlement policies for refugees from different backgrounds. Through longitudinal comparative analysis, this study examines the labour-market integration of refugees in Denmark, Norway and Sweden, searching for explanations of cross-national differences by combining statistical analyses with in-depth analyses of national policies and governance structures.

  • Disputas: 2019-05-17 10:00 KB.E3.03, Umeå
    Skotare, Tomas
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Multivariate integration and visualization of multiblock data in chemical and biological applications2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Thanks to improvements in technology more data than ever before is generated in almost all fields of science and industry.

    The data is analyzed to hopefully provide valuable information and knowledge about a product or process, such as how to improve the quality of a manufactured product.

    Analysis of collected data is often performed on a single dataset or data source at a time. In this thesis, I have focused on multiblock analysis, a concept that includes multiple sources or data blocks.  Analogous to how the human senses combine to let us experience the world around us, multiblock analysis integrates multiple data sources, providing a fuller examination of the product or process under study.

    My thesis introduces Joint and Unique Multiblock Analysis, JUMBA, a complete analysis workflow for data integration. I describe each step of JUMBA, including data pre-treatment, model building and validation as well as model interpretation. Special focus is put on several newly developed visualizations for model validation and interpretation to make it as easy as possible to draw conclusions from the analysis.

     

    By reading my thesis, the reader will gain a working understanding of the process of performing multiblock analysis, including solutions to common problems that are often encountered.

  • Falck, Per
    Nordiska museet.
    1700-tal i repris: nya fakta om gamla möbler1993Inngår i: Tack vare våra vänner!, Stockholm: Nordiska museets förlag, 1993, s. 25-44Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Collstedt, Christopher
    Södertörns högskola, Institutionen för historia och samtidsstudier, Historia.
    Towards A Biopolitics Of The Victimized Body: Creating assault as a crime against health and life, c. 1945–19652019Inngår i: Scandinavian Journal of History, ISSN 0346-8755, E-ISSN 1502-7716Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article discusses the creation of assault as a crime against health and life as this discursive process is expressed through Swedish laws, legislative discussions, and legal practice from 1945 to 1965. Inspired by Michel Foucault’s theoretical reflections on biopolitics and sociologist Thomas Lemke’s outline to a analytics of biopolitics, the article argues that a most central component in the genealogy of assault as a crime against health and life was a shift in the first post-war decades, from a predominant legal idealistic paradigm within Swedish jurisprudence, by which assault was defined as a crime against bodily integrity, to a legal realistic epistemology, imbued with the scientific knowledge and empirical ‘truth’-producing practices of modern medicine. As an effect, new discourses around the victimized body emerged, through which prevailing knowledges and ‘truths’ around violent crime and its effects were challenged and marginalized. In this discursive process, the 19th-century legal-moral category of violent crimes finally collapsed into the overarching legal category prescribed by Brottsbalken (1965) as ‘crimes against health and life’. Consequently, the victimized body was deprived of all meaning but ‘life’ and thus created as a biopolitical space, available to series of life-governing interventions and regulatory practices.

  • Aylott, Nicholas
    et al.
    Södertörns högskola, Institutionen för samhällsvetenskaper, Statsvetenskap. Södertörns högskola, Institutionen för samhällsvetenskaper, Centrum för studier av politikens organisering.
    Bolin, Niklas
    Mid Sweden University.
    A party system in flux: the Swedish parliamentary election of September 20182019Inngår i: West European Politics, ISSN 0140-2382, E-ISSN 1743-9655Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In the Swedish parliamentary election of 7 September 2018, the biggest parties, the Social Democrats and the Moderates, both lost votes compared to their scores in the previous election, but not as many as they had feared. Commensurately, the radical-right challenger party, the Sweden Democrats (SD), which had seemed certain to profit from Sweden's dramatic experience of the European migration crisis, did well, but not as well as it had hoped. The result left the array of parliamentary forces fragmented and finely balanced. Only after months of negotiations could a government be formed. Eventually, the incumbent coalition received a renewed parliamentary mandate. At the same time, the party system was transformed.

  • Jungner, Birgitta
    Nordiska museet.
    Vänner i 75 år - också svensk museihistoria!1994Inngår i: Tack vare våra vänner!, Stockholm: Nordiska museets förlag, 1994, s. 10-24Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Bejerot, Eva
    et al.
    Örebro universitet, Handelshögskolan vid Örebro Universitet.
    Hasselbladh, Hans
    Örebro universitet, Handelshögskolan vid Örebro Universitet.
    Forsberg, Tina
    Sociologiska institutionen, Stockholms universitet, Stockholm, Sverige.
    Parding, Karolina
    Luleå tekniska universitet, Luleå, Sverige.
    Sehlstedt, Therese
    Luleå tekniska universitet, Luleå, Sverige.
    Westerlund, Joakim
    Psykologiska institutionen, Stockholms universitet, Stockholm, Sverige.
    Förberedd för läraryrket? Lärare under 40 år av reformer2018Inngår i: Arbetsmarknad & Arbetsliv, ISSN 1400-9692, Vol. 24, nr 1-2, s. 7-26Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [sv]

    Studien belyser hur gymnasielärare retrospektivt uppfattar att de förberetts för sitt yrke under lärarutbildningen. Enkätsvar från 1554 gymnasielärare kategoriserades efter den tidsperiod då de examinerades. Frågan om hur väl förberedda de nyexaminerade lärarna var för sitt yrke kopplas till de nationella reformer som styrde lärarutbildningen under den period som läraren studerade. Medan utbildningen i praktisk yrkeskunskap uppfattas ha försämrats över tid, har andra områden förbättrats. Lärosäte hade inte något samband med respondenternas svarsmönster. Slutsatsen är att utbildningsreformerna har samband med förändringar i utbildningens måluppfyllelse, att förbereda lärarstudenter för sitt yrke, samt att utbildningens anpassning till yrkets krav försämrats över tid.

  • Bejerot, Eva
    et al.
    Örebro universitet, Handelshögskolan vid Örebro Universitet.
    Lampi, Laura
    Centret för utbildningsevaluering, Helsingfors universitet, Helsingfors, Finland.
    Forsberg, Tina
    Sociologiska institutionen, Stockholms universitet, stockholm, Sverige.
    Ahtiainen, Raisa
    Centret för utbildningevaluering, Helsingfors universitet, Helsingfors, Finland.
    Björk, Lisa
    Institutet för stressmedicin, Västra Götalandsregionen & Institutionen för sociologi och arbetsvetenskap, Göteborgs universitet, Göteborg, Sverige.
    Hotulainen, Risto
    Centret för utbildningevaluering, Helsingfors universitet, Helsningfors, Finland.
    Parding, Karolina
    Avdelningen för arbetsvetenskap, Luleå tekniska universitet, Luleå, Sverige.
    Sehlstedt, Therese
    Avdelningen för arbetsvetenskap, Luleå tekniska universitet, Luleå, Sverige.
    Wastensson, Gunilla
    Arbets- och miljömedicin, Göteborgs universitet, Göteborg, Sverige.
    Nyexaminerade om lärarutbildningen i Sverige och i Finland2018Inngår i: Arbetsmarknad & Arbetsliv, ISSN 1400-9692, Vol. 24, nr 3-4, s. 66-84Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [sv]

    En professionsutbildning utmärks av en spänning mellan teoretisk kunskap och praktisk yrkeskunskap. Vi vet dock inte mycket om hur en professionsutbildning bäst utformas för att förbereda studenter inför yrket. Utifrån tre enkäter, två i Sverige och en i Finland, analyseras nyexaminerade lärares uppfattning om hur förberedda de var för sitt arbete efter lärarutbildningen. Området metodik och praktik hade tydligast samband med känslan av att vara väl förberedd. I flera områden var de finska respondenterna mer kritiska än de svenska. De många positiva omdömena om den finska lärarutbildningen gjorde att vi förväntat oss ett mer positivt resultat i den finska studien.

  • Leidenberger, Sonja
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Bostrom, Sven
    Swedish Museum Nat Hist, Dept Zool, Stockholm, Sweden.
    Wayland, Matthew T.
    Univ Cambridge, Dept Zool, England.
    Morphological observations on three Baltic species of Corynosoma Lühe, 1905 (Acanthocephala, Polymorphidae)2019Inngår i: EUROPEAN JOURNAL OF TAXONOMY, ISSN 2118-9773, Vol. 514, s. 1-19Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Necropsies of Baltic grey (Halichoerus grypus) and ringed seals (Pusa hispida) presented a rare opportunity to study their acanthocephalan fauna. Both species hosted adults of three species of the genus Corynosoma Lithe, 1904, namely C. magdaleni Montreuil, 1958, C. semerme (Forsell, 1904) Lithe 1911 and C. strumosum (Rudolphi, 1802) Lithe 1904. A comparative morphological analysis of these three species of Corynosoma, combining both light and scanning electron microscopy, was performed for the first time. Sexual dimorphism in the size and shape of the trunk was observed in both C. magdaleni and C. semerme, but there was insufficient material to investigate this phenomenon in C. strumosum. Genital spines were not observed in any of the female acanthocephalans. Three possible explanations for the presence of genital spines in some females, but not others are (i) cryptic speciation, (ii) phenotypic variation and (iii) loss by extraction or shearing when the copulatory cap is released. Copulatory caps were observed on female C. semerme. The size and morphology showed considerable variability and all caps were strongly autofluoresecent.

  • Vadeby, Anna
    et al.
    Statens väg- och transportforskningsinstitut, Trafik och trafikant,TRAF, Trafiksäkerhet och trafiksystem, TST.
    Anund, Anna
    Statens väg- och transportforskningsinstitut, Trafik och trafikant,TRAF, Trafikanttillstånd, TIL.
    Hastigheter på kommunala gator i tätort: Resultat från mätningar år 20182019Rapport (Annet vitenskapelig)
    Abstract [sv]

    Syftet med föreliggande studie är att följa upp förändringar av trafikanternas hastighetsval ochhastighetsefterlevnad på det kommunala huvudvägnätet i tätort. År 2012 var startår för mätserien ochunder 2018 genomfördes den sjätte uppföljande mätningen. Enbart det kommunala huvudvägnätetmed hastighetsgränser 40–70 km/tim studerades. Mätningarna genomfördes under september månadpå 23 orter i Sverige.

    Resultaten visar att för alla fordon år 2018 var den genomsnittliga reshastigheten på det studeradevägnätet 46 km/tim. Vad gäller efterlevnaden av hastighetsgränserna var det totalt sett 66 procent somhöll hastighetsgränsen år 2018. Hastighetsefterlevnaden är sämst på gator med hastighetsbegränsning40 km/tim där endast 53 procent av trafiken höll hastighetsgränsen. På gator med 50 km/tim var det66 procent, på 60 km/tim 80 procent och på 70 km/tim var det 79 procent som höll hastighetsgränsen.Resultaten för 60 och 70 km/tim ligger därmed i princip på den målnivå om 80 procents hastighetsefterlevnadsom finns för år 2020. Om hastigheterna i de studerade punkterna 2018 jämförs medhastigheterna uppmätta 2017 så finns det inte någon signifikant skillnad.

    Sammanfattningsvis kan konstateras att de genomsnittliga reshastigheterna i tätort ligger undergällande hastighetsgränser, men bristande hastighetsefterlevnad är fortfarande ett problem, framföralltpå gator med hastighetsbegränsning 40 km/tim. För att nå målet att 80 procent av trafiken ska följagällande hastighetsgräns år 2020 är det framför allt hastighetsefterlevnaden på gator med låghastighetsbegränsning som behöver förbättras.

  • Stiernman, Mia
    et al.
    Lund University.
    Österlind, Kerstin
    Skåne University Hospital.
    Becker, Magnus
    Lund University.
    Persson, Martin
    Högskolan Kristianstad, Fakulteten för hälsovetenskap, Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap. Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education.
    Parental and health care professional views on psychosocial and educational outcomes in patients with cleft lip and/or cleft palate2019Inngår i: European journal of plastic surgery, ISSN 0930-343X, E-ISSN 1435-0130Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background

    Earlier research has investigated psychosocial and educational issues in populations of patients with cleft identifying several areas of concern. The objective of this study was to investigate current beliefs and knowledge about psychosocial and educational issues in parents and health care professionals (HCP) of children with cleft lip and/or palate (CL/P).

    Method

    Parents were interviewed concerning the view of society on people with visible differences, their child’s social life, educational progress, and information regarding psychosocial care. Interviews with HCPs concerned characteristics related with educational achievement, behavior, and social relationships. Fifteen parents of children 9 to 13 years of age with CL/P and 10 HCPs and were interviewed. Data from interviews was analyzed with thematic analysis.

    Results

    Eight children were reported to have emotional issues related to their cleft. Eleven parents, however, did not perceive that their child was treated differently in society. HCPs expressed concerns regarding for example coping with being different, low self-esteem, shyness, disadvantage on first impression, and acceptance of themselves. A majority of the HCPs did not think patient cognition and behavioral or physical development were specifically affected.

    Conclusions

    The results revealed that parent experience and views were diverse—from no specific problems related to the cleft, to both emotional and educational issues. The beliefs and level of knowledge in HCPs also varied. All HCPs, however, wished for more information and training regarding psychosocial issues.

  • Smeds, Mia (Editor)
    et al.
    Chortsen, Jakob (Editor)
    NordForsk Magasin 20182018Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [da]

    Temaet i dette års udgave af magasinet er de nordiske registre og det spændende arbejde, som nordiske forskere gennemfører, når de får adgang til registrene.

  • Smeds, Mia (Editor)
    et al.
    Chortsen, Jakob (Editor)
    NordForsk Magazine 20182018Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    The theme of this year’s magazine is Nordic registries and the exciting collaborative work Nordic researchers are able to perform when granted joint registry access.

  • Ericson, Staffan
    Södertörns högskola, Institutionen för kultur och lärande, Medie- och kommunikationsvetenskap.
    The Lecture Room (1962): on dark rooms, antennas, and the synchronization of education2019Inngår i: Fritt från fältet: Om medier, generationer och värden. Festskrift till Göran Bolin / [ed] Peter Jakobsson; Fredrik Stiernstedt, Huddinge: Södertörns högskola, 2019, s. 219-231Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Porter, Amy
    et al.
    Dian Fossey Gorilla Fund Int, Atlanta, GA 30315 USA.
    Eckardt, Winnie
    Dian Fossey Gorilla Fund Int, Atlanta, GA 30315 USA.
    Vecellio, Veronica
    Dian Fossey Gorilla Fund Int, Atlanta, GA 30315 USA.
    Guschanski, Katerina
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Niehoff, Peter Philip
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Ngobobo-As-Ibungu, Urbain
    Dian Fossey Gorilla Fund Int, Atlanta, GA 30315 USA.
    Pekeyake, Radar Nishuli
    Inst Congolais Conservat Nat, Kinshasa, DEM REP CONGO.
    Stoinski, Tara
    Dian Fossey Gorilla Fund Int, Atlanta, GA 30315 USA.
    Caillaud, Damien
    Dian Fossey Gorilla Fund Int, Atlanta, GA 30315 USA;Univ Calif Davis, Dept Anthropol, Davis, CA 95616 USA.
    Behavioral responses around conspecific corpses in adult eastern gorillas (Gorilla beringei spp.)2019Inngår i: PeerJ, ISSN 2167-8359, E-ISSN 2167-8359, Vol. 7, artikkel-id e6655Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Humans were once considered unique in having a concept of death but a growing number of observations of animal responses to dying and dead conspecifics suggests otherwise. Complex arrays of behaviors have been described ranging from corpse removal and burial among social insects to quiet attendance and caregiving among elephants and primates. Less frequently described, however, are behavioral responses of individuals from different age/sex classes or social position toward the death of conspecifics. We describe behavioral responses of mountain gorillas (Gorilla beringei beringei) to the deaths of a dominant silverback and a dominant adult female from the same social group in Volcanoes National Park in Rwanda and the responses of Grauer's gorillas (Gorilla b. graueri) to the corpse of an extra-group silverback in Kahuzi-Biega National Park, Democratic Republic of Congo. In gorillas, interactions between groups or with a lone silverback often result in avoidance or aggression. We predicted that: (i) more individuals should interact with the corpses of same-group members than with the corpse of the extra-group silverback; (ii) adult females with infants should avoid the corpse of the extra-group silverback; and (iii) in the mountain gorilla cases, individuals that shared close social relationships with the dead individual should spend more time with the corpse than other individuals in the group. We used a combination of detailed qualitative reports, photos, and videos to describe all occurrences of affiliative/investigative and agonistic behaviors observed at the corpses. We observed similar responses toward the corpses of group and extra-group individuals. Animals in all three cases showed a variety of affiliative/investigative and agonistic behaviors directed to the corpses. Animals of all age/sex classes interacted with the corpses in affiliative/investigative ways but there was a notable absence of all adult females at the corpse of the extra-group silverback. In all three cases, we observed only silverbacks and blackbacks being agonistic around and/or toward the corpses. In the mountain gorilla cases, the individuals who spent the most time with the corpses were animals who shared close social relationships with the deceased. We emphasize the similarity in the behavioral responses around the corpses of group and extra-group individuals, and suggest that the behavioral responses were influenced in part by close social relationships between the deceased and certain group members and by a general curiosity about death. We further discuss the implications close interactions with corpses have for disease transmission within and between gorilla social groups.

  • Fornäs, Johan
    Södertörns högskola, Institutionen för kultur och lärande, Medie- och kommunikationsvetenskap.
    Notes on media, culture and resilience2019Inngår i: Fritt från fältet: Om medier, generationer och värden. Festskrift till Göran Bolin / [ed] Peter Jakobsson; Fredrik Stiernstedt, Huddinge: Södertörns högskola, 2019, s. 207-218Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Stiernstedt, Fredrik
    Södertörns högskola, Institutionen för kultur och lärande, Medie- och kommunikationsvetenskap.
    Fängelse, arbete, medier2019Inngår i: Fritt från fältet: Om medier, generationer och värden. Festskrift till Göran Bolin / [ed] Peter Jakobsson; Fredrik Stiernstedt, Huddinge: Södertörns högskola, 2019, s. 187-206Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Jakobsson, Peter
    Södertörns högskola, Institutionen för kultur och lärande, Medie- och kommunikationsvetenskap.
    Från potlatch till techlash: om regleringen av digitala plattformar2019Inngår i: Fritt från fältet: Om medier, generationer och värden. Festskrift till Göran Bolin / [ed] Peter Jakobsson; Fredrik Stiernstedt, Huddinge: Södertörns högskola, 2019, s. 135-148Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Åker, Patrik
    Södertörns högskola, Institutionen för kultur och lärande, Medie- och kommunikationsvetenskap.
    Journalistik och underhållning till döds: Vem är skyldig till (för)skjutningarna på fältet?2019Inngår i: Fritt från fältet: Om medier, generationer och värden. Festskrift till Göran Bolin / [ed] Peter Jakobsson; Fredrik Stiernstedt, Huddinge: Södertörns högskola, 2019, s. 99-113Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Forsman, Michael
    Södertörns högskola, Institutionen för kultur och lärande, Medie- och kommunikationsvetenskap.
    Du blir väl lönsam på plattformen lille vän?: Mediegenerationer, undervisningstekonlogi och mediemeborgarens fostran2019Inngår i: Fritt från fältet: Om medier, generationer och värden. Festskrift till Göran Bolin / [ed] Peter Jakobsson; Fredrik Stiernstedt, Huddinge: Södertörns högskola, 2019, s. 47-68Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Liu, Ruishan
    et al.
    Stanford Univ, Dept Elect Engn, 450 Serra Mall, Stanford, CA 94305 USA.
    Mignardi, Marco
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi, Avdelningen för visuell information och interaktion. Stanford Univ, Dept Bioengn & Appl Phys, 450 Serra Mall, Stanford, CA 94305 USA;Chan Zuckerberg Biohub, 499 Illinois St, San Francisco, CA 94158 USA.
    Jones, Robert
    Stanford Univ, Dept Bioengn & Appl Phys, 450 Serra Mall, Stanford, CA 94305 USA.
    Enge, Martin
    Stanford Univ, Dept Bioengn & Appl Phys, 450 Serra Mall, Stanford, CA 94305 USA.
    Kim, Seung K.
    Stanford Univ, Dept Dev Biol, 279 Campus Dr, Stanford, CA 94305 USA.
    Quake, Stephen R.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi. Chan Zuckerberg Biohub, 499 Illinois St, San Francisco, CA 94158 USA.
    Zou, James
    Stanford Univ, Dept Biomed Data Sci, 450 Serra Mall, Stanford, CA 94305 USA;Chan Zuckerberg Biohub, 499 Illinois St, San Francisco, CA 94158 USA.
    Modeling Spatial Correlation of Transcripts with Application to Developing Pancreas2019Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, artikkel-id 5592Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Recently high-throughput image-based transcriptomic methods were developed and enabled researchers to spatially resolve gene expression variation at the molecular level for the first time. In this work, we develop a general analysis tool to quantitatively study the spatial correlations of gene expression in fixed tissue sections. As an illustration, we analyze the spatial distribution of single mRNA molecules measured by in situ sequencing on human fetal pancreas at three developmental time points-80, 87 and 117 days post-fertilization. We develop a density profile-based method to capture the spatial relationship between gene expression and other morphological features of the tissue sample such as position of nuclei and endocrine cells of the pancreas. In addition, we build a statistical model to characterize correlations in the spatial distribution of the expression level among different genes. This model enables us to infer the inhibitory and clustering effects throughout different time points. Our analysis framework is applicable to a wide variety of spatially-resolved transcriptomic data to derive biological insights.

  • Lundgren, Lars
    Södertörns högskola, Institutionen för kultur och lärande, Medie- och kommunikationsvetenskap.
    The value of being first2019Inngår i: Fritt från fältet: Om medier, generationer och värden. Festskrift till Göran Bolin / [ed] Peter Jakobsson; Fredrik Stiernstedt, Huddinge: Södertörns högskola, 2019, s. 9-19Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Zetterberg, Kent
    Nordiska museet.
    Gustav V: och övergången från det gamla till det moderna Sverige1993Inngår i: Himla många kungar, Stockholm: Nordiska museets förlag, 1993, s. 278-317Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Odelberg, Wilhelm
    Nordiska museet.
    Svenska kungar i riket, tekniken och naturvetenskapen1993Inngår i: Himla många kungar, Stockholm: Nordiska museets förlag, 1993, s. 250-277Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Proschwitz, Gunnar, von
    Nordiska museet.
    Gustaf III - en upplyst kosmopolit1993Inngår i: HImla många kungar, Stockholm: Nordiska museets förlag, 1993, s. 230-249Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Lagerqvist, Lars O.
    Nordiska museet.
    Frihetstiden1993Inngår i: Himla många kungar, Stockholm: Nordiska museets förlag, 1993, s. 197-229Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Juhas, Mario
    et al.
    Univ Zurich, Inst Med Microbiol, Gloriastr 30, CH-8006 Zurich, Switzerland.
    Widlake, Emma
    Cardiff Univ, Sch Med, Div Infect & Immun, Cardiff CF14 4XN, S Glam, Wales.
    Teo, Jeanette
    Natl Univ Singapore Hosp, Dept Lab Med, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore.
    Huseby, Douglas L
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Tyrrell, Jonathan M.
    Cardiff Univ, Sch Med, Div Infect & Immun, Cardiff CF14 4XN, S Glam, Wales.
    Polikanov, Yury S.
    Univ Illinois, Coll Liberal Arts & Sci, Dept Biol Sci, 900 South Ashland Ave,MBRB 4170, Chicago, IL 60607 USA.
    Ercan, Onur
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Petersson, Anna
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Cao, Sha
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Aboklaish, Ali F.
    Cardiff Univ, Sch Med, Div Infect & Immun, Cardiff CF14 4XN, S Glam, Wales.
    Rominski, Anna
    Univ Zurich, Inst Med Microbiol, Gloriastr 30, CH-8006 Zurich, Switzerland.
    Crich, David
    Wayne State Univ, Dept Chem, 5101 Cass Ave, Detroit, MI 48202 USA.
    Bottger, Erik C.
    Univ Zurich, Inst Med Microbiol, Gloriastr 30, CH-8006 Zurich, Switzerland.
    Walsh, Timothy R.
    Cardiff Univ, Sch Med, Div Infect & Immun, Cardiff CF14 4XN, S Glam, Wales.
    Hughes, Diarmaid
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Hobbie, Sven N.
    Univ Zurich, Inst Med Microbiol, Gloriastr 30, CH-8006 Zurich, Switzerland.
    In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii2019Inngår i: Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, E-ISSN 1460-2091, Vol. 74, nr 4, s. 944-952Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: Widespread antimicrobial resistance often limits the availability of therapeutic options to only a few last-resort drugs that are themselves challenged by emerging resistance and adverse side effects. Apramycin, an aminoglycoside antibiotic, has a unique chemical structure that evades almost all resistance mechanisms including the RNA methyltransferases frequently encountered in carbapenemase-producing clinical isolates. This study evaluates the in vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii, and provides a rationale for its superior antibacterial activity in the presence of aminoglycoside resistance determinants.

    Methods: A thorough antibacterial assessment of apramycin with 1232 clinical isolates from Europe, Asia, Africa and South America was performed by standard CLSI broth microdilution testing. WGS and susceptibility testing with an engineered panel of aminoglycoside resistance-conferring determinants were used to provide a mechanistic rationale for the breadth of apramycin activity.

    Results: MIC distributions and MIC90 values demonstrated broad antibacterial activity of apramycin against Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Morganella morganii, Citrobacter freundii, Providencia spp., Proteus mirabilis, Serratia marcescens and A. baumannii. Genotypic analysis revealed the variety of aminoglycoside-modifying enzymes and rRNA methyltransferases that rendered a remarkable proportion of clinical isolates resistant to standard-of-care aminoglycosides, but not to apramycin. Screening a panel of engineered strains each with a single well-defined resistance mechanism further demonstrated a lack of cross-resistance to gentamicin, amikacin, tobramycin and plazomicin.

    Conclusions: Its superior breadth of activity renders apramycin a promising drug candidate for the treatment of systemic Gram-negative infections that are resistant to treatment with other aminoglycoside antibiotics.

  • NordForsk Strategy 2019-20222018Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    NordForsk shall facilitate effective and trustful research cooperation in the Nordic Region, and ensure that NordForsk funded research has the highest international quality and realises Nordic added value.

  • Åberg, Alf
    De pfalziska kungarna1993Inngår i: Himla många kungar, Stockholm: Nordiska museets förlag, 1993, s. 171-196Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Disputas: 2019-06-05 14:00 F3, Stockholm
    Lindblad, Hannes
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Fastigheter och byggande, Projektkommunikation.
    BIM in Translation: Exploring Client Organisations as Drivers for Change in Construction2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    New technology is constantly being developed, presenting new opportunities and enabling innovative solutions to both known and unknown problems. Most industries place a large amount of trust in the opportunities offered by digitalisation. Information technology is being developed to enable new work practices and thereby drive change. However, the use of technology often drifts away from the developer’s intentions when it is introduced into an organisational setting. The management of such technology implementations is thus complex, both in terms of the technology itself and the organisational context in which it is implemented.

    In the architectural, engineering and construction (AEC) industry, the technology ‘Building Information Modelling’ (BIM) is currently being introduced. This industry is often described as fragmented, having low productivity and being reluctant to innovate. BIM is presented as new paradigm for this industry, as it is able to drive change towards inter-organisational collaboration, increase overall quality, and simultaneously lower costs. The industry has, however, been tentative towards BIM and widespread implementation has not yet taken place. To influence the industry towards adopting this new technology, public client organisations have been argued to play a vital role as innovation champions, demanding BIM-use through procurement. Still, there is a lack of studies exploring such implementation initiatives from the client perspective.

    In this thesis, the case of BIM implementation at the largest infrastructure client in Sweden is presented. This case shows how the client has undertaken an implementation process to both benefit its own organisation and increase productivity and innovation within the whole infrastructure branch of the AEC industry. With the purpose of problematising and contributing with reflective perspectives on the role of client organisations as drivers for industry change by implementation of information technology, the BIM implementation at this organisation is viewed as an empirical example of how information technology is introduced to influence an inter-organisational network of actors and establish change. 

    The case is analysed from the perspective of an analytical framework, taking inspiration from actor-network theory and sociology of translation. Thus, the implementation is viewed as a process of translation, where key actors are identified and enrolled into using BIM. Viewing BIM implementation as a translation reveals a complex network of actors linked to the implementation in question. The implementation is developed as a sequential translation, where project managers are intended to act as delegates, demanding and promoting BIM in their projects.

    This thesis problematises the role of client organisations in initiating change through the implementation of technology. Enrolling actors into using BIM has, in the studied case, primarily been done by the development of new demand documents. This strategy has, however, been problematic as the demands have not been accepted as intended. Instead, the results of this thesis argue for the importance of client organisations as negotiators, and that they are not only needed to establish demand for new technology.