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  • Backlund, Ann-Charlotte
    Kommunala kulturmiljöprograms betydelse för bevarande av kulturvärden: kulturmiljöövervakning/fallstudie1998 (oppl. 1)Bok (Annet vitenskapelig)
  • Uppdragsarkeologi: allmänna råd till verkställighetsföreskrifter angående förfarandet vid vissa beslut m.m. enligt 2 kap. 10-13 §§ lagen (1988:950) om kulturminnen m.m. (KRFS 1998:01)1998Bok (Annet vitenskapelig)
  • Wedman, Stina
    Stickspån: pärt, spiller, spilkspån1998 (oppl. 1)Bok (Annet vitenskapelig)
  • Magnus, Bente
    Birka: [English]1998Bok (Annet vitenskapelig)
  • Magnus, Bente
    Birka1998Bok (Annet vitenskapelig)
  • Palmqvist, Lena
    Landsbygdens folkliga byggnadsskick1998 (oppl. 1)Bok (Annet vitenskapelig)
  • Westlund, Hans
    Infrastruktur i Sverige under tusen år1998 (oppl. 1)Bok (Annet vitenskapelig)
  • Lindqvist, Jan Erik
    Gammal kalkputs: analys och utvärdering1999 (oppl. 1)Bok (Annet vitenskapelig)
  • Stibéus, Magnus
    et al.
    Ängeby, Gisela
    Varnums medeltida sockenkyrkogård och Kristinehamns äldsta stadsbebyggelse: arkeologiska undersökningar i kvarteren Andromeda, Mars, Tellus och Venus1997Bok (Annet vitenskapelig)
  • Aronsson, Kjell-Åke
    Samiska kulturmiljöer i Sverige: en forskningsöversikt1995Bok (Annet vitenskapelig)
  • Rönnby, Johan
    Bålverket: om samhällsförändring och motstånd med utgångspunkt från det tidigmedeltida Bulverket i Tingstäde tr...1995Bok (Fagfellevurdert)
  • Olausson, Michael
    Det inneslutna rummet: om kultiska hägnader, fornborgar och befästa gårdar i Uppland från 1300 f Kr till Kristi födelse. Katalog1995Bok (Fagfellevurdert)
  • Biörnstad, Arne
    Nordiska museet.
    "Pundstol" för pepparrot1958Inngår i: Fataburen: Nordiska museet och Skansens årsbok, Stockholm: Nordiska museets förlag, 1958, s. 213-214Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Burström, Mats
    Fornlämningar och folkminnen1997 (oppl. 1)Bok (Annet vitenskapelig)
  • Brunius, Jan
    Nordiska museet.
    En modell av Vikhus säteri1958Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1958, s. 222-227Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Kozma, Radoslav
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Mörch, Patrik Rödin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Höglund, Jacob
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Genomic regions of speciation and adaptation among three species of grouse2019Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, artikkel-id 812Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Understanding the molecular basis of adaption is one of the central goals in evolutionary biology and when investigated across sister species it can provide detailed insight into the mechanisms of speciation. Here, we sequence the genomes of 34 individuals from three closely related grouse species in order to uncover the genomic architecture of speciation and the genes involved in adaptation. We identify 6 regions, containing 7 genes that show lineage specific signs of differential selection across the species. These genes are involved in a variety of cell processes ranging from stress response to neural, gut, olfactory and limb development. Genome wide neutrality test statistics reveal a strong signal of population expansion acting across the genomes. Additionally, we uncover a 3.5 Mb region on chromosome 20 that shows considerably lower levels of differentiation across the three grouse lineages, indicating possible action of uniform selection in this region.

  • Friberg, Gunnel
    Natursten i byggnader. Skaraborgs och Älvsborgs län1996 (oppl. 1)Bok (Annet vitenskapelig)
  • Lagerquist, Marshall
    Nordiska museet.
    Skrin av fajans1958Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1958, s. 219-221Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Defourny, Jean
    et al.
    Univ Liege, Unit Cell & Tissue Biol, GIGA Neurosci, CHU B36, B-4000 Liege, Belgium;Univ Liege, Dev Neurobiol Unit, GIGA Neurosci, CHU B36, B-4000 Liege, Belgium.
    Peuckert, Christiane
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Kullander, Klas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap.
    Malgrange, Brigitte
    Univ Liege, Dev Neurobiol Unit, GIGA Neurosci, CHU B36, B-4000 Liege, Belgium.
    EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions2019Inngår i: ISCIENCE, ISSN 2589-0042, Vol. 11, s. 246-257Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The cochlear sensory epithelium contains a functionally important triangular fluid-filled space between adjacent pillar cells referred to as the tunnel of Corti. However, the molecular mechanisms leading to local cell-cell separation during development remain elusive. Here we show that EphA4 associates with ADAM10 to promote the destruction of E-cadherin-based adhesions between adjacent pillar cells. These cells fail to separate from each other, and E-cadherin abnormally persists at the pillar cell junction in EphA4 forward-signaling-deficient mice, as well as in the presence of ADAM10 inhibitor. Using immunolabeling and an in situ proximity ligation assay, we found that EphA4 forms a complex with E-cadherin and its sheddase ADAM10, which could be activated by ephrin-B2 across the pillar cell junction to trigger the cleavage of E-cadherin. Altogether, our findings provide a new molecular insight into the regulation of adherens junctions, which might be extended to a variety of physiological or pathological processes.

  • Karlenby, Leif ()
    Mittens rike: arkeologiska berättelser från Närke2003 (oppl. 1)Bok (Annet vitenskapelig)
  • Friberg, Gunnel ()
    Natursten i byggnader. Uppsala, Västmanlands och Örebro län1996 (oppl. 1)Bok (Annet vitenskapelig)
  • Stavenow-Hidemark, Elisabet
    Nordiska museet.
    Textilier från tidigt 1700-tal1958Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1958, s. 216-219Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Borgen brinner!: en utställning om Birkas försvar1997Bok (Annet vitenskapelig)
  • Bager-Sjögren, Lars
    et al.
    Swedish Agency for Growth Policy Analysis, Sweden.
    Klofsten, Magnus
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Projekt, innovationer och entreprenörskap. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, HELIX Competence Centre.
    Krakowski, Sebastian
    Geneva Business School of Economics and Management, Switzerland.
    Firm growth and survival, from a 14- year perspective: A cohort analysis2017Inngår i: Frontiers of Entrepreneurship Research, ISSN 0740-7416, Vol. 37, nr 16, s. 358-363, artikkel-id 2Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This study examines whether early growth is important for the short- and long-term survival and development of new firms. For this purpose, we use registry data for a specific cohort of Swedish firms that tracks their development until their exit, or up to 14 years, at which point only 8% of the firms remain. We find growth to be clearly associated with increased survival of the firms, that the number of employees (in the previous year) is positively correlated with survival in following years, and somewhat surprisingly, that subsidiaries face a significantly larger hazard of closure than independent firms.

  • Husain, Sajid
    et al.
    Indian Inst Technol Delhi, Dept Phys, Thin Film Lab, New Delhi 110016, India.
    Sisodia, Naveen
    Indian Inst Technol Delhi, Dept Phys, Thin Film Lab, New Delhi 110016, India.
    Chaurasiya, Avinash Kumar
    SN Bose Natl Ctr Basic Sci, Dept Condensed Matter Phys & Mat Sci, Block JD,Sect 3, Kolkata 700106, India.
    Kumar, Ankit
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Singh, Jitendra Pal
    Yadav, Brajesh S.
    Solid State Phys Lab, Lucknow Rd, Delhi 110054, India.
    Akansel, Serkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Chae, Keun Hwa
    Korea Inst Sci & Technol, Adv Anal Ctr, Seoul 02792, South Korea.
    Barman, Anjan
    SN Bose Natl Ctr Basic Sci, Dept Condensed Matter Phys & Mat Sci, Block JD,Sect 3, Kolkata 700106, India.
    Muduli, P. K.
    Indian Inst Technol Delhi, Dept Phys, Thin Film Lab, New Delhi 110016, India.
    Svedlindh, Peter
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Chaudhary, Sujeet
    Indian Inst Technol Delhi, Dept Phys, Thin Film Lab, New Delhi 110016, India.
    Observation of Skyrmions at Room Temperature in Co2FeAl Heusler Alloy Ultrathin Film Heterostructures2019Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, artikkel-id 1085Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Magnetic skyrmions are topological spin-textures having immense potential for energy efficient spintronic devices. Here, we report the observation of stable skyrmions in unpatterned Ta/Co2FeAl(CFA)/MgO thin film heterostructures at room temperature in remnant state employing magnetic force microscopy. It is shown that these skyrmions consisting of ultrathin ferromagnetic CFA Heusler alloy result from strong interfacial Dzyaloshinskii-Moriya interaction (i-DMI) as evidenced by Brillouin light scattering measurements, in agreement with the results of micromagnetic simulations. We also emphasize on room temperature observation of multiple skyrmions which can be stabilized for suitable combinations of CFA layer thickness, perpendicular magnetic anisotropy, and i-DMI. These results provide a significant step towards designing of room temperature spintronic devices based on skyrmions in full Heusler alloy based thin films.

  • Emilsson, Gustav
    et al.
    Röder, Evelyn
    Malekian, Bita
    Xiong, Kunli
    Manzi, John
    Tsai, Feng-Ching
    Cho, Nam-Joon
    Bally, Marta
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi. Umeå universitet, Medicinska fakulteten, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM).
    Dahlin, Andreas
    Nanoplasmonic Sensor Detects Preferential Binding of IRSp53 to Negative Membrane Curvature2019Inngår i: Frontiers in Chemistry, E-ISSN 2296-2646, Vol. 7, artikkel-id 1Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Biosensors based on plasmonic nanostructures are widely used in various applications and benefit from numerous operational advantages. One type of application where nanostructured sensors provide unique value in comparison with, for instance, conventional surface plasmon resonance, is investigations of the influence of nanoscale geometry on biomolecular binding events. In this study, we show that plasmonic "nanowells" conformally coated with a continuous lipid bilayer can be used to detect the preferential binding of the insulin receptor tyrosine kinase substrate protein (IRSp53) I-BAR domain to regions of negative surface curvature, i.e., the interior of the nanowells. Two different sensor architectures with and without an additional niobium oxide layer are compared for this purpose. In both cases, curvature preferential binding of IRSp53 (at around 0.025 nm(-1) and higher) can be detected qualitatively. The high refractive index niobium oxide influences the near field distribution and makes the signature for bilayer formation less clear, but the contrast for accumulation at regions of negative curvature is slightly higher. This work shows the first example of analyzing preferential binding of an average-sized and biologically important protein to negative membrane curvature in a label-free manner and in real-time, illustrating a unique application for nanoplasmonic sensors.

  • Carrieri, Daniele
    et al.
    Univ Exeter, Egenis, England.
    Howard, Heidi Carmen
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Centrum för forsknings- och bioetik.
    Benjamin, Caroline
    Univ Cent Lancashire UCLan, Sch Community Hlth & Midwifery, Preston, Lancs, England;Liverpool Womens NHS Hosp Trust, Merseyside & Cheshire Clin Genet Serv, Liverpool, Merseyside, England.
    Clarke, Angus J.
    Cardiff Univ, Sch Med, Cardiff, S Glam, Wales.
    Dheensa, Sandi
    Univ Southampton, Fac Med, Clin Eth & Law, Southampton, Hants, England.
    Doheny, Shane
    Cardiff Univ, Sch Med, Cardiff, S Glam, Wales.
    Hawkins, Naomi
    Univ Exeter, Law Sch, Exeter, Devon, England.
    Halbersma-Konings, Tanya F.
    Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
    Jackson, Leigh
    Univ Exeter, Sch Med, Egenis, England.
    Kayserili, Hulya
    Koc Univ KUSoM, Sch Med, Med Genet Dept, Istanbul, Turkey.
    Kelly, Susan E.
    Univ Exeter, Egenis, England.
    Lucassen, Anneke M.
    Univ Southampton, Fac Med, Clin Eth & Law, Southampton, Hants, England;Univ Hosp Southampton NHS Fdn Trust, Wessex Clin Genet Serv, Southampton, Hants, England.
    Mendes, Alvaro
    Univ Porto, I3S, IBMC Inst Mol & Cell Biol, UnIGENe, Porto, Portugal;Univ Porto, I3S, IBMC Inst Mol & Cell Biol, CGPP Ctr Predict & Prevent Genet, Porto, Portugal.
    Rial-Sebbag, Emmanuelle
    Univ Paul Sabatier Toulouse III, INSERM, UMR 1027, Toulouse, France.
    Stefansdottir, Vigdis
    Natl Univ Hosp Iceland, Dept Genet & Mol Med, Landspitali, Reykjavik, Iceland.
    Turnpenny, Peter D.
    Royal Devon & Exeter NHS Fdn Trust, Clin Genet, Exeter, Devon, England.
    van El, Carla G.
    Vrije Univ, Amsterdam UMC, Sect Community Genet, Dept Clin Genet, Amsterdam, Netherlands;Vrije Univ, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
    van Langen, Irene M.
    Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
    Cornel, Martina C.
    Vrije Univ, Amsterdam UMC, Sect Community Genet, Dept Clin Genet, Amsterdam, Netherlands;Vrije Univ, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
    Forzano, Francesca
    Guys & St Thomas NHS Fdn Trust, Clin Genet Dept, London, ON, Canada.
    Recontacting patients in clinical genetics services: recommendations of the European Society of Human Genetics2019Inngår i: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 27, nr 2, s. 169-182Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Technological advances have increased the availability of genomic data in research and the clinic. If, over time, interpretation of the significance of the data changes, or new information becomes available, the question arises as to whether recontacting the patient and/or family is indicated. The Public and Professional Policy Committee of the European Society of Human Genetics (ESHG), together with research groups from the UK and the Netherlands, developed recommendations on recontacting which, after public consultation, have been endorsed by ESHG Board. In clinical genetics, recontacting for updating patients with new, clinically significant information related to their diagnosis or previous genetic testing may be justifiable and, where possible, desirable. Consensus about the type of information that should trigger recontacting converges around its clinical and personal utility. The organization of recontacting procedures and policies in current health care systems is challenging. It should be sustainable, commensurate with previously obtained consent, and a shared responsibility between healthcare providers, laboratories, patients, and other stakeholders. Optimal use of the limited clinical resources currently available is needed. Allocation of dedicated resources for recontacting should be considered. Finally, there is a need for more evidence, including economic and utility of information for people, to inform which strategies provide the most cost-effective use of healthcare resources for recontacting.

  • Triebner, Kai
    et al.
    Univ Bergen, Dept Clin Sci, Jonas Lies Veg 87, N-5021 Bergen, Norway;Univ Bergen, Core Facil Metabol, Jonas Lies Veg 87, N-5021 Bergen, Norway.
    Accordini, Simone
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Inst Biol 2, Str Le Grazie 8, I-37134 Verona, Italy.
    Calciano, Lucia
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Inst Biol 2, Str Le Grazie 8, I-37134 Verona, Italy.
    Johannessen, Ane
    Haukeland Hosp, Dept Occupat Med, Jonas Lies Vei 65, N-5021 Bergen, Norway;Univ Bergen, Ctr Int Hlth, Jekteviksbakken 31, N-5009 Bergen, Norway.
    Benediktsdottir, Bryndis
    Univ Iceland, Fac Med, Reykjavik, Iceland.
    Bifulco, Ersilia
    Univ Bergen, Dept Clin Sci, Jonas Lies Veg 87, N-5021 Bergen, Norway;Univ Bergen, Core Facil Metabol, Jonas Lies Veg 87, N-5021 Bergen, Norway.
    Demoly, Pascal
    Univ Montpellier, Univ Hosp Montpellier, Dept Pulmonol, Div Allergy, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier, France;Sorbonne Univ, French Natl Inst Hlth & Med Res, Pierre Louis Inst Epidemiol & Publ Hlth, 56 Blvd Vincent Auriol, F-75646 Paris, France.
    Dharmage, Shyamali C.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, 207 Bouverie St, Carlton, Vic 3052, Australia.
    Franklin, Karl A.
    Umea Univ, Dept Surg & Perioperat Sci, Koksvagen 11, S-90185 Umea, Sweden.
    Garcia-Aymerich, Judith
    ISGlobal, Doctor Aiguader 88, Barcelona 08003, Spain;Univ Pompeu Fabra, Doctor Aiguader 88, Barcelona 08003, Spain;CIBER Epidemiol & Publ Hlth, Doctor Aiguader 88, Barcelona 08003, Spain.
    Gullon Blanco, Jose Antonio
    Univ Hosp San Agustin, Dept Pneumol, Camino Heros 4, Aviles 33410, Spain.
    Heinrich, Joachim
    Ludwig Maximilian Univ Munich, Inst & Outpatient Clin Occupat Social & Environm, Ziemssenstr 1, D-80336 Munich, Germany.
    Holm, Mathias
    Univ Gothenburg, Dept Occupat & Environm Med, Medicinaregatan 16A, S-41390 Gothenburg, Sweden.
    Jarvis, Debbie
    Imperial Coll, Natl Heart & Lung Inst, 1b Manresa Rd, London SW3 6LR, England.
    Jogi, Rain
    Tartu Univ Hosp, Lung Clin, Dept Lung Med, Riia 167, EE-51014 Tartu, Estonia.
    Lindberg, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Martinez-Moratalla, Jesus
    Hlth Serv Castilla La Mancha, Pulmonol Serv, Albacete Univ Hosp Complex, Albacete, Spain;Castilla La Mancha Univ, Fac Med Albacete, Albacete, Spain.
    Muniozguren Agirre, Nerea
    Basque Govt, Dept Hlth, Unit Epidemiol & Publ Hlth, Alameda Rekalde 39A, Bilbao 48008, Spain.
    Pin, Isabelle
    Univ Grenoble Alpes, Univ Hosp Grenoble Alpes, French Natl Inst Hlth & Med Res, Inst Adv Biosci,Dept Pediat, CS 10217, F-38043 Grenoble 9, France.
    Probst-Hensch, Nicole
    Swiss Trop & Publ Hlth Inst, Socinstr 58, CH-4002 Basel, Switzerland;Univ Basel, Dept Publ Hlth, Peterspl 1, CH-4001 Basel, Switzerland.
    Raherison, Chantal
    Bordeaux Univ, Bordeaux Populat Hlth Res, U1219, 146 Rue Leo Saignat, F-33076 Bordeaux, France.
    Luis Sanchez-Ramos, Jose
    Univ Huelva, Dept Nursing, Ave Tres Marzo S-N, Huelva 21071, Spain.
    Schlunssen, Vivi
    Aarhus Univ, Dept Publ Hlth, Bartholins Alle 2, DK-8000 Aarhus, Denmark;Natl Res Ctr Working Environm, Lerso Pk Alle 105, DK-2100 Copenhagen, Denmark.
    Svanes, Cecilie
    Haukeland Hosp, Dept Occupat Med, Jonas Lies Vei 65, N-5021 Bergen, Norway;Univ Bergen, Ctr Int Hlth, Jekteviksbakken 31, N-5009 Bergen, Norway.
    Hustad, Steinar
    Univ Bergen, Dept Clin Sci, Jonas Lies Veg 87, N-5021 Bergen, Norway;Univ Bergen, Core Facil Metabol, Jonas Lies Veg 87, N-5021 Bergen, Norway.
    Leynaert, Benedicte
    French Natl Inst Hlth & Med Res, UMR1152, Team Epidemiol, Paris, France.
    Real, Francisco Gomez
    Univ Bergen, Dept Clin Sci, Jonas Lies Veg 87, N-5021 Bergen, Norway;Haukeland Hosp, Dept Gynecol & Obstet, Jonas Lies Veg 65, N-5021 Bergen, Norway.
    Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)2019Inngår i: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 120, s. 29-34Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: Menopause involves hypoestrogenism, which is associated with numerous detrimental effects, including on respiratory health. Hormone replacement therapy (HRT) is often used to improve symptoms of menopause. The effects of HRT on lung function decline, hence lung ageing, have not yet been investigated despite the recognized effects of HRT on other health outcomes. Study design: The population-based multi-centre European Community Respiratory Health Survey provided complete data for 275 oral HRT users at two time points, who were matched with 383 nonusers and analysed with a two-level linear mixed effects regression model. Main outcome measures: We studied whether HRT use was associated with the annual decline in forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). Results: Lung function of women using oral HRT for more than five years declined less rapidly than that of nonusers. The adjusted difference in FVC decline was 5.6 mL/y (95%CI: 1.8 to 9.3, p = 0.01) for women who had taken HRT for six to ten years and 8.9 mL/y (3.5 to 14.2, p = 0.003) for those who had taken it for more than ten years. The adjusted difference in FEV1 decline was 4.4 mL/y (0.9 to 8.0, p = 0.02) with treatment from six to ten years and 5.3 mL/y (0.4 to 10.2, p = 0.048) with treatment for over ten years. Conclusions: In this longitudinal population-based study, the decline in lung function was less rapid in women who used HRT, following a dose-response pattern, and consistent when adjusting for potential confounding factors. This may signify that female sex hormones are of importance for lung ageing.

  • Jiang, Xia
    et al.
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA;Karolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, Nobels Vagen 13, S-17177 Stockholm, Sweden.
    Finucane, Hilary K.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA;Broad Inst MIT & Harvard, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA.
    Schumacher, Fredrick R.
    Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, 10900 Eucid Ave, Cleveland, OH 44106 USA;Univ Hosp, Seidman Canc Ctr, Cleveland, OH 44106 USA.
    Schmit, Stephanie L.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr MRC CANCONT, Tampa, FL 33612 USA;H Lee Moffitt Canc Ctr & Res Inst, Dept Gastrointestinal Oncol, 12902 Magnolia Dr MRC CANCONT, Tampa, FL 33612 USA.
    Tyrer, Jonathan P.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Han, Younghun
    Geisel Sch Med Dartmouth, Dept Biomed Data Sci, 1 Med Ctr Dr, Dartmouth, NS, Lebanon.
    Michailidou, Kyriaki
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Cyprus Inst Neurol & Genet, Dept Elect Microscopy Mol Pathol, CY-1683 Nicosia, Cyprus.
    Lesseur, Corina
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Int Agcy Res Canc, Sect Genet, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Kuchenbaecker, Karoline B.
    UCL, Div Psychiat, Maple House,149 Tottenham Court Rd, London W1T 7NF, England;UCL, UCL Genet Inst, Gower St, London WC1E 6BT, England.
    Dennis, Joe
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Conti, David V.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 48109 USA.
    Casey, Graham
    Univ Virginia, Publ Hlth Sci, POB 800717, Charlottesville, VI 80071 USA;Univ Virginia, Ctr Publ Hlth Genom, POB 800717, Charlottesville, VI 80071 USA.
    Gaudet, Mia M.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St NW, Atlanta, GA 30303 USA.
    Huyghe, Jeroen R.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA.
    Albanes, Demetrius
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Aldrich, Melinda C.
    Vanderbilt Univ, Div Epidemiol, Dept Thorac Surg, Med Ctr, 609 Oxford House, Nashville, TN 37232 USA.
    Andrew, Angeline S.
    Dartmouth Hitchcock Med Ctr, Dept Neurol, 7927 Rubin Bldg,Room 860,One Med Ctr Dr, Lebanon, NH 3756 USA.
    Andrulis, Irene L.
    Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Fred ALitwin Ctr Canc Genet, 600 Univ Ave, Toronto, ON M5G 1X5, Canada;Univ Toronto, Dept Mol Genet, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada.
    Anton-Culver, Hoda
    Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, 224 Irvine Hall, Irvine, CA 92617 USA.
    Antoniou, Antonis C.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Antonenkova, Natalia N.
    NNAlexandrov Res Inst Oncol & Med Radiol, Settlement Lesnoy 2, Minsk 223040, BELARUS.
    Arnold, Susanne M.
    Univ Kentucky, Markey Canc Ctr, 800 Rose St,Cc445, Lexington, KY 40508 USA.
    Aronson, Kristan J.
    Queens Univ, Dept Publ Hlth Sci, 10 Stuart St, Kingston, ON K7L 3N6, Canada;Queens Univ, Canc Res Inst, 10 Stuart St, Kingston, ON K7L 3N6, Canada.
    Arun, Banu K.
    Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, 1155 Pressler St, Houston, TX 77030 USA.
    Bandera, Elisa V.
    Rutgers Canc Inst New Jersey, Canc Prevent & Control Program, 195 Little Albany St,Room 5568, New Brunswick, NJ 08903 USA.
    Barkardottir, Rosa B.
    Landspitali Univ Hosp, Dept Pathol, IS-101 Reykjavik, Iceland;Univ Iceland, Fac Med, BMC Biomed Ctr, Vatnsmyrarvegi 16, IS-101 Reykjavik, Iceland.
    Barnes, Daniel R.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Batra, Jyotsna
    Australian Prostate Canc Res Ctr Qld, Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia;Queensland Univ Technol, Inst Hlth & Biomed Innovat, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia;Queensland Univ Technol, Sch Biomed Sci, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia.
    Beckmann, Matthias W.
    Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen Nuremberg, Dept Gynecol & Obstet, Univ Str 21-23, D-91054 Erlangen, Germany.
    Benitez, Javier
    Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain;Biomed Network Rare Dis CIBERER, AvMonforte Lemos,3-5Pabellon 11Planta 0, Madrid 28029, Spain.
    Benlloch, Sara
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
    Berchuck, Andrew
    Duke Univ, Dept Obstet & Gynecol, Med Ctr, 25171 Morris Bldg, Durham, NC 27710 USA.
    Berndt, Sonja I.
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Bickeboeller, Heike
    Univ Med Ctr Goettingen, Dept Genet Epidemiol, Humboldtallee 32, D-37073 Gottingen, Germany.
    Bien, Stephanie A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, 1959 NE Pacific St,Hlth Sci Bldg,F-350, Seattle, WA 98195 USA.
    Blomqvist, Carl
    Univ Helsinki, Helsinki Univ Hosp, Dept Oncol, Haartmaninkatu 4, FIN-00290 Helsinki, Finland;Orebro Univ Hosp, Dept Oncol, S-70185 Orebro, Sweden.
    Boccia, Stefania
    Fdn Policlin Univ AGemelli IRCCS, I-00168 Rome, Italy;Univ Cattolica Sacro Cuore, I-00168 Rome, Italy.
    Bogdanova, Natalia V.
    NNAlexandrov Res Inst Oncol & Med Radiol, Settlement Lesnoy 2, Minsk 223040, BELARUS;Hannover Med Sch, Dept Radiat Oncol, Carl Neuberg Str 1, D-30625 Hannover, Germany;Hannover Med Sch, Gynaecol Res Unit, Carl Neuberg Str 1, D-30625 Hannover, Germany.
    Bojesen, Stig E.
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev Ringvej 75, DK-75 Herlev, Denmark;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev Ringvej 75, DK-75 Herlev, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
    Bolla, Manjeet K.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Brauch, Hiltrud
    DrMargarete Fischer Bosch Inst Clin Pharmacol, Auerbachstr112, D-70376 Stuttgart, Germany;Univ Tubingen, Geschwister Scholl Pl, D-72074 Tubingen, Germany;German Canc Res Ctr, German Canc Consortium DKTK, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Brenner, Hermann
    German Canc Res Ctr, German Canc Consortium DKTK, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Natl Ctr Tumor Dis NCT, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Brenton, James D.
    Univ Cambridge, Canc Res UK Cambridge Inst, Li Ka Shing Ctr, Robinson Way, Cambridge CB2 0RE, England.
    Brook, Mark N.
    Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
    Brunet, Joan
    CIBERONC, Catalan Inst Oncol, IDIBGI Inst Invest Biomed Girona, Genet Counseling Unit,Hereditary Canc Program, AvFranca S-N, Girona 17007, Spain.
    Brunnstrom, Hans
    Lund Univ, Clin Sci, Box 117, S-22100 Lund, Sweden;Dept Genet & Pathol, Div Lab Med, S-22185 Lund, Sweden.
    Buchanan, Daniel D.
    Univ Melbourne, Victorian Comprehens Canc Ctr, Ctr Canc Res, Parkville, Vic 3010, Australia;Univ Melbourne, Dept Clin Pathol, Colorectal Oncogen Grp, Parkville, Vic 3010, Australia;Royal Melbourne Hosp, Genom Med & Family Canc Clin, Parkville, Vic 3010, Australia.
    Burwinkel, Barbara
    Heidelberg Univ, Dept Obstet & Gynecol, Neuenheimer Feld 440, D-69120 Heidelberg, Germany;German Canc Res Ctr, Mol Epidemiol Grp, C080,Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Butzow, Ralf
    Univ Helsinki, Dept Pathol, Biomed Helsinki 4th Floor,Haartmaninkatu 8, Helsinki 00029, Finland;Helsinki Univ Hosp, Biomed Helsinki 4th Floor,Haartmaninkatu 8, Helsinki 00029, Finland.
    Cadoni, Gabriella
    Fdn Policlin Univ AGemelli IRCCS, I-00168 Rome, Italy;Univ Cattolica Sacro Cuore, I-00168 Rome, Italy.
    Caldes, Trinidad
    Hosp Clin San Carlos, Inst Invest Sanitaria San Carlos IdISSC, Med Oncol Dept, Ctr Invest Biomed Red Canc CIBERONC, Calle Prof Martin Lagos, Madrid 28040, Spain.
    Caligo, Maria A.
    Univ Pisa, Dept Lab Med, Sect Genet Oncol, Via Roma 67, I-56126 Pisa, Italy;Univ Hosp Pisa, Via Roma 67, I-56126 Pisa, Italy.
    Campbell, Ian
    Peter MacCallum Canc Ctr, 305 Grattan St, Melbourne, Vic 3000, Australia;Univ Melbourne, Sir Peter MacCallum Dept Oncol, 305 Grattan St, Melbourne, Vic 3000, Australia.
    Campbell, Peter T.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St NW, Atlanta, GA 30303 USA.
    Cancel-Tassin, Geraldine
    Sorbonne Univ, Tenon Hosp, GRC N 5 ONCOTYPE URO, F-75020 Paris, France;Tenon Hosp, CeRePP, F-75020 Paris, France.
    Cannon-Albright, Lisa
    Univ Utah, Dept Med, Div Genet Epidemiol, Sch Med, Salt Lake City, UT 84112 USA;George EWahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT 84112 USA.
    Campa, Daniele
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Univ Pisa, Dept Biol, I-56126 Pisa, Italy.
    Caporaso, Neil
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Carvalho, Andre L.
    Barretos Canc Hosp, Mol Oncol Res Ctr, Rua Antenor Duarte Villela 1331, BR-784400 Barretos, SP, Brazil;Barretos Canc Hosp, Head & Neck Surg Dept, Pio 12,1331 Antenor Duarte Villela St, BR-14784400 Barretos, SP, Brazil.
    Chan, Andrew T.
    Massachusetts Gen Hosp, Div Gastroenterol, 55 Fruit St, Boston, MA 02114 USA;Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Dept Med, 181 Longwood Ave, Boston, MA 02115 USA.
    Chang-Claude, Jenny
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Univ Med Ctr Hamburg Eppendorf, UCCH, Canc Epidemiol Grp, Martinistr 52, D-20246 Hamburg, Germany.
    Chanock, Stephen J.
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Chen, Chu
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1100 Fairview Ave N, Seattle, WA 98109 USA.
    Christiani, David C.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA.
    Claes, Kathleen B. M.
    Univ Ghent, Ctr Med Genet, De Pintelaan 185, B-9000 Ghent, Belgium.
    Claessens, Frank
    Katholieke Univ Leuven, Dept Cellular & Mol Med, Mol Endocrinol Lab, B-3000 Leuven, Belgium.
    Clements, Judith
    Australian Prostate Canc Res Ctr Qld, Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia;Queensland Univ Technol, Inst Hlth & Biomed Innovat, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia;Queensland Univ Technol, Sch Biomed Sci, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia.
    Collee, J. Margriet
    Erasmus MC, Dept Clin Genet, Wytemaweg 80, NL-3015 CN Rotterdam, Netherlands.
    Correa, Marcia Cruz
    Univ Puerto Rico Med Sci Campus, San Juan, PR 00936 USA;Comprehens Canc Ctr, San Juan, PR 00936 USA.
    Couch, Fergus J.
    Mayo Clin, Dept Lab Med & Pathol, 200 First StSW, Rochester, MN 55905 USA.
    Cox, Angela
    Univ Sheffield, Sheffield Inst Nucle Acids SInFoNiA, Dept Oncol & Metab, Western Bank, Sheffield S10 2TN, S Yorkshire, England.
    Cunningham, Julie M.
    Mayo Clin, Dept Lab Med & Pathol, 200 First StSW, Rochester, MN 55905 USA.
    Cybulski, Cezary
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, ulUnii Lubelskiej 1, PL-71252 Szczecin, Poland.
    Czene, Kamila
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden.
    Daly, Mary B.
    Fox Chase Canc Ctr, Dept Clin Genet, 333 Cottman Ave, Philadelphia, PA 19111 USA.
    defazio, Anna
    Univ Sydney, Westmead Inst Med Res, Ctr Canc Res, 176 Hawkesbury Rd, Sydney, NSW 2145, Australia;Westmead Hosp, Dept Gynaecol Oncol, Hawkesbury Rd & Darcy Rd, Sydney, NSW 2145, Australia.
    Devilee, Peter
    Leiden Univ Med Ctr, Dept Pathol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands;Leiden Univ Med Ctr, Dept Human Genet, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands.
    Diez, Orland
    Univ Hosp Vall dHebron, Vall dHebron Inst Oncol VHIO, Clin & Mol Genet Area, Oncogenet Grp, Passeig Vall dHebron 119-129, Barcelona 08035, Spain.
    Gago-Dominguez, Manuela
    Complejo Hosp Univ Santiago, SERGAS, Inst Invest Sanitaria Santiago de Compostela IDIS, Genom Med Grp,Galician Fdn Genom Med, Travesia Choupana S-N, Santiago De Compostela 15706, Spain;Univ Calif San Diego, Moores Canc Ctr, 3855 Hlth Sci Dr, La Jolla, CA 92037 USA.
    Donovan, Jenny L.
    Univ Bristol, Sch Social & Community Med, Bristol BS8 1TH, Avon, England.
    Doerk, Thilo
    Duell, Eric J.
    ICO IDIBELL, Canc Epidemiol Res Program, Unit Nutr & Canc, AvGran Via 199-203, Barcelona 08908, Spain.
    Dunning, Alison M.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Dwek, Miriam
    Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, 309 Regent St, London W1B 2HW, England.
    Eccles, Diana M.
    Univ Southampton, Canc Sci Acad Unit, Fac Med, Tremona Rd, Southampton SO16 6YD, Hants, England.
    Edlund, Christopher K.
    Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA.
    Edwards, Digna R. Velez
    Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Vanderbilt Epidemiol Ctr,Vanderbilt Genet Inst, 2525 West End Ave,Suite 600, Nashville, TN 37203 USA.
    Ellberg, Carolina
    Lund Univ, Dept Canc Epidemiol, Clin Sci, Barngatan 4, S-22242 Lund, Sweden.
    Evans, D. Gareth
    Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Ctr Genom Med, Div Evolut & Genom Sci,St Marys Hosp, Oxford Rd, Manchester M13 9WL, Lancs, England.
    Fasching, Peter A.
    Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen Nuremberg, Dept Gynecol & Obstet, Univ Str 21-23, D-91054 Erlangen, Germany;Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol & Oncol, 10833 Le Conte Ave, Los Angeles, CA 90095 USA.
    Ferris, Robert L.
    Univ Pittsburgh, UPMC Hillman Canc Ctr, Dept Otolaryngol, Canc Pavil,Suite 500,5150 Ctr Ave, Pittsburgh, PA 15232 USA.
    Liloglou, Triantafillos
    Univ Liverpool, Mol & Clin Canc Med, Roy Castle Lung Canc Res Programme, Inst Translat Med, Wiliam Duncan Bldg,6 West Derby St, Liverpool L69 3BX, Merseyside, England.
    Figueiredo, Jane C.
    Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, 8700 Beverly Blvd, Los Angeles, CA 90048 USA;Univ Southern Calif, Keck Sch Med, 1450 Biggy St, Los Angeles, CA 90033 USA.
    Fletcher, Olivia
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Inst Canc Res, Breast Canc Now Toby Robins Res Ctr, 123 Old Brompton Rd, London SW7 3RP, England.
    Fortner, Renee T.
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Fostira, Florentia
    Natl Ctr Sci Res Demokritos, Mol Diagnost Lab, INRASTES, Neapoleos 10, Athens 15310, Greece.
    Franceschi, Silvia
    Int Agcy Res Canc, Sect Infect, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Friedman, Eitan
    Chaim Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Emek HaEla St 1, IL-52621 Ramat Gan, Israel;Tel Aviv Univ, Sackler Fac Med, Haim Levanon 30, IL-69978 Ramat Aviv, Israel.
    Gallinger, Steven J.
    Mt Sinai Hosp, Dept Surg, 600 Univ Ave, Toronto, ON M5G 1X5, Canada;Samuel Lunenfeld Res Inst, 600 Univ Ave, Toronto, ON M5G 1X5, Canada;Univ Hlth Network Toronto Gen Hosp, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada.
    Ganz, Patricia A.
    Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Div Canc Prevent & Control Res, Sch Med, 650 Charles Young Dr South, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Div Canc Prevent & Control Res, Sch Publ Hlth, 650 Charles Young Dr South, Los Angeles, CA 90095 USA.
    Garber, Judy
    Dana Farber Canc Inst, Canc Risk & Prevent Clin, 450 Brookline Ave, Boston, MA 02215 USA.
    Garcia-Saenz, Jose A.
    Hosp Clin San Carlos, Inst Invest Sanitaria San Carlos IdISSC, Med Oncol Dept, Ctr Invest Biomed Red Canc CIBERONC, Calle Prof Martin Lagos, Madrid 28040, Spain.
    Gayther, Simon A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA;Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Ctr Canc Prevent & Translat Genom, Spielberg Bldg,8725 Alden Dr, Los Angeles, CA 90048 USA;Cedars Sinai Med Ctr, Dept Biomed Sci, Spielberg Bldg,8725 Alden Dr, Los Angeles, CA 90048 USA.
    Giles, Graham G.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, 615 St Kilda Rd, Melbourne, Vic 3004, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia;Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
    Godwin, Andrew K.
    Univ Kansas, Dept Pathol & Lab Med, Med Ctr, 3901 Rainbow Blvd, Kansas City, KS 66160 USA.
    Goldberg, Mark S.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;McGill Univ, Dept Med, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada;McGill Univ, Royal Victoria Hosp, Div Clin Epidemiol, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada.
    Goldgar, David E.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Univ Utah, Huntsman Canc Inst, Dept Dermatol, Sch Med, 2000 Circle Hope, Salt Lake City, UT 84112 USA.
    Goode, Ellen L.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Mayo Clin, Dept Hlth Sci Res, 200 First StSW, Rochester, MN 55905 USA.
    Goodman, Marc T.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Canc Prevent & Control, 8700 Beverly Blvd,Room 1S37, Los Angeles, CA 90048 USA;Cedars Sinai Med Ctr, Dept Biomed Sci, Commun & Populat Hlth Res Inst, 8700 Beverly Blvd,Room 1S37, Los Angeles, CA 90048 USA.
    Goodman, Gary
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Swedish Canc Inst, Div Publ Hlth Sci, 1221 Madison StSte 300, Seattle, WA 98109 USA.
    Grankvist, Kjell
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Umea Univ, Unit Clin Chem, Dept Med Biosci, 6M Van 2, S-90185 Umea, Sweden.
    Greene, Mark H.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;NCI, Clin Genet Branch, DCEG, 9609 Med Ctr Dr, Bethesda, MD 20850 USA.
    Gronberg, Henrik
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden.
    Gronwald, Jacek
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, ulUnii Lubelskiej 1, PL-71252 Szczecin, Poland.
    Guenel, Pascal
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Univ Paris Saclay, Univ Paris Sud, Ctr Res Epidemiol & Populat Hlth CESP, Canc & Environm Grp,INSERM, F-94805 Villejuif, France.
    Hakansson, Niclas
    Karolinska Inst, Div Nutr Epidemiol, Dept Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.
    Hall, Per
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden;Soder Sjukhuset, Dept Oncol, Sjukhusbacken 10, S-11883 Stockholm, Sweden.
    Hamann, Ute
    German Canc Res Ctr, Mol Genet Breast Canc, Neuenheimer Feld 580, D-69120 Heidelberg, Germany.
    Hamdy, Freddie C.
    Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Fac Med Sci, Oxford OX1 2JD, England.
    Hamilton, Robert J.
    Princess Margaret Canc Ctr, Dept Surg Oncol, 610 Univ Ave, Toronto, ON M5G 2M9, Canada.
    Hampe, Jochen
    Tech Univ Dresden, Univ Hosp Dresden, Dept Internal Med 1, D-01307 Dresden, Germany.
    Haugen, Aage
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Natl Inst Occupat Hlth STAMI, Gydas Vei 8, N-0033 Oslo, Norway.
    Heitz, Florian
    DrHorst Schmidt Kliniken Wiesbaden, Dept Gynecol & Gynecol Oncol, Ludwig Erhard Str 100, D-65199 Wiesbaden, Germany;Knappschaft GmbH, Dept Gynecol & Gynecol Oncol, Kliniken Essen Mitte, EvangHuyssens Stiftung, Henricistr 92, D-45136 Essen, Germany.
    Herrero, Rolando
    Int Agcy Res Canc, Early Detect & Prevent Sect, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Hillemanns, Peter
    Hoffmeister, Michael
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Hogdall, Estrid
    Danish Canc Soc Res Ctr, Dept Virus Lifestyle & Genes, Strandboulevarden 49, DK-2100 Copenhagen, Denmark;Univ Copenhagen, Herlev Hosp, Dept Pathol, Mol Unit, Herlev Ringvej 75, DK-75 Herlev, Denmark.
    Hong, Yun-Chul
    Seoul Natl Univ, Coll Med, Prevent Med, 1 Gwanak Ro, Seoul 151742, South Korea.
    Hopper, John L.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia.
    Houlston, Richard
    Inst Canc Res, German Res Ctr Environm Hlth, Ingolstadter Landstr1, Sutton SM2 5NG, Surrey, England.
    Hulick, Peter J.
    NorthShore Univ HealthSystem, Ctr Med Genet, Evanston, IL 1000 USA;Univ Chicago, Pritzker Sch Med, 924 E 57th St, Chicago, IL 60637 USA.
    Hunter, David J.
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA.
    Huntsman, David G.
    BC Canc Agcy, Vancouver Gen Hosp, British Columbias Ovarian Canc Res OVCARE Program, 3427-600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada;Univ British Columbia, 3427-600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada;BC Canc Agcy Res Ctr, Dept Mol Oncol, 3427-600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada.
    Idos, Gregory
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 48109 USA.
    Imyanitov, Evgeny N.
    Univ British Columbia, Dept Pathol & Lab Med, 3427-600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada;NNPetrov Inst Oncol, Leningradskaya Ul 68, St Petersburg 197758, Russia.
    Ingles, Sue Ann
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 48109 USA.
    Isaacs, Claudine
    Georgetown Univ, Lombardi Comprehens Canc Ctr, 3800 Reservoir Rd, Washington, DC 20007 USA.
    Jakubowska, Anna
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, ulUnii Lubelskiej 1, PL-71252 Szczecin, Poland;Pomeranian Med Univ, Independent Lab Mol Biol & Genet Diagnost, Rybacka 1, PL-70204 Szczecin, Poland.
    James, Paul
    Univ Melbourne, Sir Peter MacCallum Dept Oncol, 305 Grattan St, Melbourne, Vic 3000, Australia;Peter MacCallum Canc Ctr, Parkville Familial Canc Ctr, 305 Grattan St, Melbourne, Vic 3000, Australia.
    Jenkins, Mark A.
    Univ Melbourne, Victorian Comprehens Canc Ctr, Ctr Canc Res, Parkville, Vic 3010, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia.
    Johansson, Mattias
    Int Agcy Res Canc, Sect Genet, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Johansson, Mikael
    Umea Univ, Dept Radiat Sci, 6M Van 2, S-90185 Umea, Sweden.
    John, Esther M.
    Stanford Univ, Sch Med, Div Oncol, Dept Med, 780 Welch Rd, Stanford, CA 94304 USA;Stanford Univ, Sch Med, Stanford Canc Inst, 780 Welch Rd, Stanford, CA 94304 USA.
    Joshi, Amit D.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
    Kaneva, Radka
    Med Univ Sofia, Fac Med, Dept Med Chem & Biochem, Mol Med Ctr, Sofia 1504, Bulgaria.
    Karlan, Beth Y.
    Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, 8700 Beverly Blvd, Los Angeles, CA 90048 USA.
    Kelemen, Linda E.
    Med Univ South Carolina, Hollings Canc Ctr, 68 President St Bioengineering Bldg,MSC955, Charleston, SC 29425 USA;Med Univ South Carolina, Dept Publ Hlth Sci, 68 President St Bioengineering Bldg,MSC955, Charleston, SC 29425 USA.
    Kuhl, Tabea
    Univ Med Ctr Hamburg Eppendorf, UCCH, Canc Epidemiol, Martinistr 52, D-20246 Hamburg, Germany.
    Khaw, Kay-Tee
    Univ Cambridge, Dept Publ Hlth & Primary Care, Clin Gerontol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Khusnutdinova, Elza
    Bashkir State Univ, Dept Genet & Fundamental Med, ulZaki Validi 32, Ufa 450076, Russia;Russian Acad Sci, Inst Biochem & Genet, Ufa Sci Ctr, 71 Prosp Oktyabrya, Ufa 450054, Russia.
    Kibel, Adam S.
    Brigham & Womens Hosp, Div Urol Surg, Boston, MA USA.
    Kiemeney, Lambertus A.
    Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Med Ctr, Geert Grooteplein 21, NL-6525 EZ Nijmegen, Netherlands.
    Kim, Jeri
    Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, 1155 Pressler St, Houston, TX 77030 USA.
    Kjaer, Susanne K.
    Danish Canc Soc Res Ctr, Dept Virus Lifestyle & Genes, Strandboulevarden 49, DK-2100 Copenhagen, Denmark;Univ Copenhagen, Dept Gynaecol, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
    Knight, Julia A.
    Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Prosserman Ctr Populat Hlth Res, 60 Murray St, Toronto, ON M5T 3L9, Canada;Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, 155 Coll St, Toronto, ON M5T 3M7, Canada.
    Kogevinas, Manolis
    Biomed Network Rare Dis CIBERER, AvMonforte Lemos,3-5Pabellon 11Planta 0, Madrid 28029, Spain;ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona 08036, Spain;IMIM Hosp del Mar Res Inst, Barcelona 08003, Spain;UPF, Barcelona 08002, Spain.
    Kote-Jarai, Zsofia
    Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
    Koutros, Stella
    NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, 9609 Med Ctr Dr, Bethesda, MD 20892 USA.
    Kristensen, Vessela N.
    Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, Radiumhosp, Ullernchausseen 70, N-0379 Oslo, Norway;Univ Oslo, Fac Med, Inst Clin Med, Kirkeveien 166, N-0450 Oslo, Norway;Univ Oslo, Oslo Univ Hosp, Dept Clin Mol Biol, Kirkeveien 166, N-0450 Oslo, Norway.
    Kupryjanczyk, Jolanta
    Maria Sklodowska Curie Inst, Ctr Oncol, Dept Pathol & Lab Diagnost, Roentgena 5, PL-02781 Warsaw, Poland.
    Lacko, Martin
    Maastricht Univ, Med Ctr, Dept Otorhinolaryngol, Head & Neck Surg, PDebyelaan 25,POBox 5800, NL-6202 AZ Maastricht, Netherlands.
    Lam, Stephan
    British Columbia Canc Agcy, Dept Integrat Oncol, Room 10-111 675 West 10th Ave, Vancouver, BC V5Z 1L3, Canada.
    Lambrechts, Diether
    VIB, VIB Ctr Canc Biol, Herestr 49, B-3001 Leuven, Belgium;Univ Leuven, Dept Human Genet, Lab Translat Genet, Oude Markt 13, B-3000 Leuven, Belgium.
    Landi, Maria Teresa
    NCI, Integrat Tumor Epidemiol Branch, DCEG, 9609 Med Ctr Dr,Room SG 7E106, Rockville, MD 20850 USA.
    Lazarus, Philip
    Washington State Univ, Coll Pharm, PBS 431 POB 1495, Spokane, WA 99210 USA.
    Le, Nhu D.
    BC Canc Agcy, Canc Control Res, 675 West 10th Ave, Vancouver, BC V5Z 1L3, Canada.
    Lee, Eunjung
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA.
    Lejbkowicz, Flavio
    Carmel Hosp, Clalit Natl Israeli Canc Control Ctr, Clalit Hlth Serv, 2 Horev St, IL-3436212 Haifa, Israel.
    Lenz, Heinz-Josef
    Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA.
    Leslie, Goska
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Lessel, Davor
    Univ Med Ctr Hamburg Eppendorf, Inst Human Genet, Martinistr 52, D-20246 Hamburg, Germany.
    Lester, Jenny
    Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, 8700 Beverly Blvd, Los Angeles, CA 90048 USA.
    Levine, Douglas A.
    Mem Sloan Kettering Canc Ctr, Dept Surg, Gynecol Serv, 1275 York Ave, New York, NY 10065 USA;NYU Langone Med Ctr, Laura & Isaac Pearlmutter Canc Ctr, Gynecol Oncol, 240 East 38th St 19th Floor, New York, NY 10016 USA.
    Li, Li
    Case Western Reserve Univ, Mary Ann Swetland Ctr Environm Hlth, Dept Family Med & Community Hlth, Cleveland, OH 44106 USA;Inst Invest Sanitaria Santiago de Compostela IDIS, Serv Galego Saude SERGAS, Santiago De Compostela 15706, Spain.
    Li, Christopher I.
    Fred Hutchinson Canc Res Ctr, Translat Res Program, Seattle, WA 98109 USA.
    Lindblom, Annika
    Karolinska Inst, Karolinska Univ Hosp, Dept Mol Med & Surg, S-17176 Stockholm, Sweden.
    Lindor, Noralane M.
    Mayo Clin Arizona, Hlth Sci Res, 13400 EShea Blvd, Scottsdale, AZ 85259 USA.
    Liu, Geoffrey
    Princess Margaret Canc Ctr, Div Epidemiol, 610 Univ Ave, Toronto, ON M5G 2M9, Canada.
    Loupakis, Fotios
    Ist Oncol Veneto IRCCS, Dept Clin & Expt Oncol, Unit Oncol 1, I-35122 Padua, Italy.
    Lubinski, Jan
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, ulUnii Lubelskiej 1, PL-71252 Szczecin, Poland.
    Maehle, Lovise
    Oslo Univ Hosp, Dept Med Genet, Kirkeveien 166, N-0450 Oslo, Norway.
    Maier, Christiane
    Univ Hosp Ulm, Inst Human Genet, Prittwitzstr 43, D-89075 Ulm, Germany.
    Mannermaa, Arto
    Univ Eastern Finland, Translat Canc Res Area, Yliopistonranta 1, Kuopio 70210, Finland;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, KuopioYliopistonranta 1, Kuopio 70210, Finland;Kuopio Univ Hosp, Dept Clin Pathol, Imaging Ctr, Puijonlaaksontie 2, Kuopio 70210, Finland.
    Le Marchand, Loic
    Univ Hawaii, Program Epidemiol, Ctr Canc, 701 Ilalo St, Honolulu, HI 96813 USA.
    Margolin, Sara
    Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-17177 Stockholm, Sweden.
    May, Taymaa
    Univ Hlth Network, Div Gynecol Oncol, Princess Margaret Hosp, 610 Univ Ave,OPG Wing 6-811, Toronto, ON M5G 2M9, Canada.
    McGuffog, Lesley
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Meindl, Alfons
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Tech Univ Munich, Div Gynaecol & Obstet, Arcisstr 21, D-80333 Munich, Germany.
    Middha, Pooja
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Heidelberg Univ, Fac Med, Neuenheimer Feld 672, D-69120 Heidelberg, Germany.
    Miller, Austin
    Roswell Pk Canc Inst, Stat & Data Management Ctr, NRG Oncol, Elm & Carlton St, Buffalo, NY 14263 USA.
    Milne, Roger L.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, 615 St Kilda Rd, Melbourne, Vic 3004, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia.
    MacInnis, Robert J.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, 615 St Kilda Rd, Melbourne, Vic 3004, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia.
    Modugno, Francesmary
    Magee Womens Res Inst, Canc Res Ctr, Pittsburgh, PA 15213 USA;Hillman Canc Ctr, Pittsburgh, PA 15213 USA;Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Gynecol Oncol, 300 Halket St, Pittsburgh, PA 15213 USA.
    Montagna, Marco
    Veneto Inst Oncol IOV IRCCS, Immunol & Mol Oncol Unit, Via Gattamelata 64, I-35128 Padua, Italy.
    Moreno, Victor
    Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol, Barcelona 08908, Spain;Univ Barcelona, Barcelona 08908, Spain.
    Moysich, Kirsten B.
    Roswell Pk Canc Inst, Div Canc Prevent & Control, Elm & Carlton St, Buffalo, NY 14263 USA.
    Mucci, Lorelei
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA.
    Muir, Kenneth
    Univ Manchester, Div Populat Hlth Hlth Serv Res & Primary Care, Oxford Rd, Manchester M13 9PL, Lancs, England;Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry CV4 7AL, W Midlands, England.
    Mulligan, Anna Marie
    Univ Toronto, Dept Lab Med & Pathobiol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada;Univ Hlth Network, Lab Med Program, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada.
    Nathanson, Katherine L.
    Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Dept Med, 3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
    Neal, David E.
    Univ Cambridge, Canc Res UK Cambridge Inst, Li Ka Shing Ctr, Robinson Way, Cambridge CB2 0RE, England;Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Fac Med Sci, Oxford OX1 2JD, England;Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB1 8RN, England.
    Ness, Andrew R.
    Univ Bristol, NIHR Bristol Biomed Res Ctr Nutr Theme, Upper Maudlin St, Bristol BS2 8AE, Avon, England.
    Neuhausen, Susan L.
    Beckman Res Inst City Hope, Dept Populat Sci, 1500 E Duarte, Duarte, CA 91010 USA.
    Nevanlinna, Heli
    Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.
    Newcomb, Polly A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, 1959 NE Pacific St,Hlth Sci Bldg,F-350, Seattle, WA 98195 USA.
    Newcomb, Lisa F.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Dept Urol, Seattle, WA 98195 USA.
    Nielsen, Finn Cilius
    Copenhagen Univ Hosp, Ctr Genom Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
    Nikitina-Zake, Liene
    Latvian Biomed Res & Study Ctr, Ratsupites Str 1, LV-1067 Riga, Latvia.
    Nordestgaard, Borge G.
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev Ringvej 75, DK-75 Herlev, Denmark;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev Ringvej 75, DK-75 Herlev, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
    Nussbaum, Robert L.
    Univ Calif San Francisco, Canc Genet & Prevent Program, 1600 Div St, San Francisco, CA 94143 USA.
    Offit, Kenneth
    Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, Clin Genet Res Lab, 1275 York Ave, New York, NY 10065 USA;Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10065 USA.
    Olah, Edith
    Natl Inst Oncol, Dept Mol Genet, Rath Gyorgy u7-9, H-1122 Budapest, Hungary.
    Al Olama, Ali Amin
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 0QQ, England.
    Olopade, Olufunmilayo I.
    Univ Chicago, Ctr Clin Canc Genet, 5841S Maryland Ave, Chicago, IL 60637 USA.
    Olshan, Andrew F.
    Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, 135 Dauer Dr, Chapel Hill, NC 27599 USA;UNC Lineberger Comprehens Canc Ctr, 450 West Dr, Chapel Hill, NC 27599 USA.
    Olsson, Hakan
    Lund Univ, Dept Canc Epidemiol, Clin Sci, Barngatan 4, S-22242 Lund, Sweden.
    Osorio, Ana
    Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain;Biomed Network Rare Dis CIBERER, AvMonforte Lemos,3-5Pabellon 11Planta 0, Madrid 28029, Spain.
    Pandha, Hardev
    Univ Surrey, Guildford GU2 7XH, Surrey, England.
    Park, Jong Y.
    HLee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA.
    Pashayan, Nora
    UCL, Dept Appl Hlth Res, 1-19 Torrington Pl, London WC1E 6BT, England;Univ Cambridge, Dept Oncol, Strangeways Lab, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England.
    Parsons, Michael T.
    QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, 300 Herston Rd, Brisbane, Qld 4006, Australia.
    Pejovic, Tanja
    Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, 3181 SW Sam Jackson Pk Rd,L-466, Portland, OR 97239 USA;Oregon Hlth & Sci Univ, Knight Canc Inst, 3181 SW Sam Jackson Pk Rd,L-466, Portland, OR 97239 USA.
    Penney, Kathryn L.
    Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Dept Med, 181 Longwood Ave, Boston, MA 02115 USA.
    Peters, Wilbert H. M.
    Radboud Univ Nijmegen, Med Ctr, Dept Gastroenterol, Geert Grooteplein Zuid 10,Internal BOBox 433, NL-6525 GA Nijmegen, Netherlands.
    Phelan, Catherine M.
    HLee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA.
    Phipps, Amanda I.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St, Seattle, WA 98195 USA.
    Plaseska-Karanfilska, Dijana
    Macedonian Acad Sci & Arts, Res Ctr Genet Engn & Biotechnol Georgi DEfremov, Blvd Krste Petkov Misirkov, Skopje 1000, Macedonia.
    Pring, Miranda
    Univ Bristol, Bristol Dent Sch, Lower Maudlin St, Bristol BS1 2LY, Avon, England.
    Prokofyeva, Darya
    Bashkir State Univ, Dept Genet & Fundamental Med, ulZaki Validi 32, Ufa 450076, Russia.
    Radice, Paolo
    INT, Fdn IRCCS, Dept Res, Unit Mol Bases Genet Risk & Genet Testing, Via Giacomo Venezian 1, I-20133 Milan, Italy.
    Stefansson, Kari
    Decode Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.
    Ramus, Susan J.
    Univ NSW Sydney, Sch Womens & Childrens Hlth, Fac Med, 18 High St, Sydney, NSW 2052, Australia;Garvan Inst Med Res, Kinghorn Canc Ctr, 384 Victoria St, Sydney, NSW 2010, Australia.
    Raskin, Leon
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, 1161 21st Ave S D3300, Nashville, TN 37232 USA.
    Rennert, Gad
    Carmel Hosp, Clalit Natl Canc Control Ctr, 7 Michal St, IL-34362 Haifa, Israel;Technion Fac Med, 7 Michal St, IL-34362 Haifa, Israel.
    Rennert, Hedy S.
    Carmel Hosp, Clalit Natl Canc Control Ctr, 7 Michal St, IL-34362 Haifa, Israel;Technion Fac Med, 7 Michal St, IL-34362 Haifa, Israel.
    van Rensburg, Elizabeth J.
    Univ Pretoria, Dept Genet, Private Bag X323, ZA-0007 Arcadia, South Africa.
    Riggan, Marjorie J.
    Duke Univ, Dept Obstet & Gynecol, Med Ctr, 25171 Morris Bldg, Durham, NC 27710 USA.
    Risch, Harvey A.
    Yale Sch Publ Hlth, Dept Chron Dis Epidemiol, 60 Coll St, New Haven, CT 06510 USA.
    Risch, Angela
    Salzburg Univ, Dept Mol Biol, Canc Ctr Cluster Salzburg, PLUS, Billrothstr11, A-5020 Salzburg, Austria;DKFZ German Canc Res Ctr, Div Epigen & Canc Risk Factors, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;German Ctr Lung Res DZL, TLRC H, D-69120 Heidelberg, Germany.
    Roobol, Monique J.
    Erasmus Univ, Med Ctr, Dept Urol, Wytemaweg 80, NL-3015 CN Rotterdam, Netherlands.
    Rosenstein, Barry S.
    Icahn Sch Med Mt Sinai, Dept Radiat Oncol, 1425 Madison Ave, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, 1425 Madison Ave, New York, NY 10029 USA.
    Rossing, Mary Anne
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Dept Epidemiol, M4 C308,1100 Fairview Ave N, Seattle, WA 98109 USA.
    De Ruyck, Kim
    Univ Ghent, Fac Med & Hlth Sci, Basic Med Sci, De Pintelaan 185, B-9000 Ghent, Belgium.
    Saloustros, Emmanouil
    Univ Hosp Heraklion, Hereditary Canc Clin, Iraklion 71110, Greece.
    Sandler, Dale P.
    NIEHS, Epidemiol Branch, NIH, 111TWAlexander Dr, Res Triangle Pk, NC 27709 USA.
    Sawyer, Elinor J.
    Kings Coll London, Guys Hosp, Guys Hosp Great Maze Pond, Res Oncol, London SE1 9RT, England.
    Schabath, Matthew B.
    HLee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA.
    Schleutker, Johanna
    Univ Turku, Inst Biomed, Turku 20014, Finland;Turku Univ Hosp, Dept Med Genet, Div Lab, Turku 20014, Finland;Univ Tampere, Fac Med & Life Sci, Prostate Canc Res Ctr, Tampere 33014, Finland;Univ Tampere, BioMediTech Inst, Tampere 33014, Finland.
    Schmidt, Marjanka K.
    Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Pathol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands;Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.
    Setiawan, V. Wendy
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1450 Biggy St, Los Angeles, CA 90033 USA.
    Shen, Hongbing
    Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Dept Epidemiol & Biostat,Sch Publ Hlth, 101 Longmian Ave, Nanjing 211166, Jiangsu, Peoples R China.
    Siegel, Erin M.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr MRC CANCONT, Tampa, FL 33612 USA.
    Sieh, Weiva
    Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Genet & Genom Sci, 1425 Madison Ave,2nd Floor, New York, NY 10029 USA.
    Singer, Christian F.
    Med Univ Vienna, Dept OB GYN, Waehringer Guertel 18-20, A-1090 Vienna, Austria;Med Univ Vienna, Ctr Comprehens Canc, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
    Slattery, Martha L.
    Univ Utah, Dept Internal Med, Hlth Sci Ctr, 295 Chipeta Way, Salt Lake City, UT 84132 USA.
    Sorensen, Karina Dalsgaard
    Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark;Aarhus Univ, Dept Clin Med, DK-8200 Aarhus, Denmark.
    Southey, Melissa C.
    Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, 246 Clayton Rd, Clayton, Vic 3168, Australia;Univ Melbourne, Dept Clin Pathol, Cnr Grattan St, Melbourne, Vic 3010, Australia;Royal Parade, Melbourne, Vic 3010, Australia.
    Spurdle, Amanda B.
    QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, 300 Herston Rd, Brisbane, Qld 4006, Australia.
    Stanford, Janet L.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St, Seattle, WA 98195 USA.
    Stevens, Victoria L.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St NW, Atlanta, GA 30303 USA.
    Stintzing, Sebastian
    Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Med 3, Marchioninistr15, D-81377 Munich, Germany.
    Stone, Jennifer
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia;Curtin Univ, Curtin UWA Ctr Genet Origins Hlth & Dis, 35 Stirling Hwy, Perth, WA 6000, Australia;Univ Western Australia, 35 Stirling Hwy, Perth, WA 6000, Australia.
    Sundfeldt, Karin
    Univ Gothenburg, Inst Clin Sci, Sahlgrenska Canc Ctr, Dept Obstet & Gynecol, Bla Straket 6, S-41345 Gothenburg, Sweden.
    Sutphen, Rebecca
    Univ S Florida, Coll Med, Epidemiol Ctr, 3650 Spectrum Blvd,Suite 100, Tampa, FL 33612 USA.
    Swerdlow, Anthony J.
    Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England;Inst Canc Res, Div Breast Canc Res, London SW7 3RP, England.
    Tajara, Eloiza H.
    Sch Med Sao Jose do Rio Preto, Dept Mol Biol, Av Brig Faria Lima 5416 Vila Sao Pedro, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil;Univ Sao Paulo, Inst Biosci, Dept Genet & Evolut Biol, Rua Matao 321, BR-05508090 Sao Paulo, SP, Brazil.
    Tangen, Catherine M.
    Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98109 USA.
    Tardon, Adonina
    Univ Oviedo, Fac Med, Campus Cristo S-N, E-33006 Oviedo, Spain;CIBERESP, Campus Cristo S-N, Oviedo 33006, Spain.
    Taylor, Jack A.
    NIEHS, Epidemiol Branch, NIH, 111TWAlexander Dr, Res Triangle Pk, NC 27709 USA;NIEHS, Epigenet & Stem Cell Biol Lab, NIH, 111TWAlexander Dr, Res Triangle Pk, NC 27709 USA.
    Teare, M. Dawn
    Univ Sheffield, Sch Hlth & Related Res ScHARR, Med Stat Grp, Regent Court,30 Regent St, Sheffield S1 4DA, S Yorkshire, England.
    Teixeira, Manuel R.
    Portuguese Oncol Inst, Dept Genet, Rua DrAntonio Bernardino de Almeida 62, P-4220072 Porto, Portugal;Univ Porto, Biomed Sci Inst ICBAS, RJorge de Viterbo Ferreira 228, P-4050013 Porto, Portugal.
    Terry, Mary Beth
    Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, 722 West 168th St, New York, NY 10032 USA.
    Terry, Kathryn L.
    Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, 221 Longwood Ave RFB 368, Boston, MA 02115 USA;Harvard THChan Sch Publ Hlth, 221 Longwood Ave RFB 368, Boston, MA 02115 USA.
    Thibodeau, Stephen N.
    Mayo Clin, Dept Lab Med & Pathol, 200 First StSW, Rochester, MN 55905 USA.
    Thomassen, Mads
    Odense Univ Hosp, Dept Clin Genet, Sonder Blvd 29, DK-5000 Odense C, Denmark.
    Bjorge, Line
    Haukeland Hosp, Dept Gynecol & Obstet, N-5021 Bergen, Norway;Univ Bergen, Dept Clin Sci, Ctr Canc Biomarkers CCBIO, N-5021 Bergen, Norway.
    Tischkowitz, Marc
    McGill Univ, Dept Human Genet & Oncol, Program Canc Genet, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada;Univ Cambridge, Dept Med Genet, Hills Rd, Cambridge CB2 0QQ, England.
    Toland, Amanda E.
    Ohio State Univ, Dept Canc Biol & Genet, 460W12th Ave, Columbus, OH 43210 USA.
    Torres, Diana
    German Canc Res Ctr, Mol Genet Breast Canc, Neuenheimer Feld 580, D-69120 Heidelberg, Germany;Pontificia Univ Javeriana, Inst Human Genet, Carrera 7 40-90, Bogota, Colombia.
    Townsend, Paul A.
    Univ Manchester, NIHR Manchester Biomed Res Ctr, Fac Biol Med & Hlth,Manchester Acad Hlth Sci Ctr, Div Canc Sci,Manchester Canc Res Ctr,Hlth Innovat, Manchester M20 4GJ, Lancs, England.
    Travis, Ruth C.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England.
    Tung, Nadine
    Beth Israel Deaconess Med Ctr, Dept Med Oncol, 330 Brookline Ave, Boston, MA 02215 USA.
    Tworoger, Shelley S.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA;HLee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA.
    Ulrich, Cornelia M.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Utah, Huntsman Canc Inst, 2000 Circle Hope,Rm 4125, Salt Lake City, UT 84112 USA;Univ Utah, Dept Populat Hlth Sci, 2000 Circle Hope,Rm 4125, Salt Lake City, UT 84112 USA.
    Usmani, Nawaid
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Univ Alberta, Cross Canc Inst, Dept Oncol, 116 St & 85 Ave, Edmonton, AB T6G 2R3, Canada;Univ Alberta, Cross Canc Inst, Div Radiat Oncol, 116 St & 85 Ave, Edmonton, AB T6G 2R3, Canada.
    Vachon, Celine M.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Mayo Clin, Dept Hlth Sci Res, 200 First StSW, Rochester, MN 55905 USA.
    Van Nieuwenhuysen, Els
    Univ Hosp Leuven, Dept Obstet & Gynaecol, Div Gynecol Oncol, Herestr 49, B-3000 Leuven, Belgium;Univ Hosp Leuven, Leuven Canc Inst, Herestr 49, B-3000 Leuven, Belgium.
    Vega, Ana
    Biomed Network Rare Dis CIBERER, AvMonforte Lemos,3-5Pabellon 11Planta 0, Madrid 28029, Spain;Fdn Publ Galega Med Xenom, Calle Choupana S-N, Santiago De Compostela 15706, Spain;Inst Invest Sanitaria Santiago de Compostela, Calle Choupana S-N, Santiago De Compostela 15706, Spain.
    Aguado-Barrera, Miguel Elias
    Fdn Publ Galega Med Xenom, Calle Choupana S-N, Santiago De Compostela 15706, Spain;Inst Invest Sanitaria Santiago de Compostela, Calle Choupana S-N, Santiago De Compostela 15706, Spain.
    Wang, Qin
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Webb, Penelope M.
    QIMR Berghofer Med Res Inst, Populat Hlth Dept, 300 Herston Rd, Brisbane, Qld 4006, Australia.
    Weinberg, Clarice R.
    NIEHS, Biostat & Computat Biol Branch, NIH, 111TWAlexander Dr, Res Triangle Pk, NC 27709 USA.
    Weinstein, Stephanie
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Weissler, Mark C.
    Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27514 USA.
    Weitzel, Jeffrey N.
    City Hope Clin Canc Genom Community Res Network, 1500 East Duarte Rd, Duarte, CA 91010 USA.
    West, Catharine M. L.
    Univ Manchester, Manchester Acad Hlth Sci Ctr, Christie Hosp NHS Fdn Trust, Div Canc Sci,Manchester Canc Res Ctr, Manchester M13 9PL, Lancs, England.
    White, Emily
    Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Dept Epidemiol, 1100 Fairview Ave N, Seattle, WA 98109 USA.
    Whittemore, Alice S.
    Stanford Univ, Dept Hlth Res & Policy Epidemiol, Sch Med, 259 Campus Dr, Stanford, CA 94305 USA;Stanford Univ, Dept Biomed Data Sci, Sch Med, 259 Campus Dr, Stanford, CA 94305 USA.
    Wichmann, H-Erich
    Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, Chair Epidemiol, D-85764 Neuherberg, Germany;Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, Chair Epidemiol, Munich, Bavaria, Germany;German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Epidemiol, Ingolstadter Landstr1, D-85764 Neuherberg, Germany;Tech Univ Munich, Inst Med Stat & Epidemiol, D-80333 Munich, Germany.
    Wiklund, Fredrik
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden.
    Winqvist, Robert
    Univ Oulu, Lab Canc Genet & Tumor Biol, Canc & Translat Med Res Unit, Bioctr Oulu, Aapistie 5A, SF-90220 Oulu, Finland;Northern Finland Lab Ctr Oulu, Lab Canc Genet & Tumor Biol, Aapistie 5A, Oulu 90220, Finland.
    Wolk, Alicja
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Ortopedi. Karolinska Inst, Div Nutr Epidemiol, Dept Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.
    Woll, Penella
    Univ Sheffield, Weston Pk Hosp, Acad Unit Clin Oncol, Whitham Rd, Sheffield S10 2SJ, S Yorkshire, England.
    Woods, Michael
    Mem Univ Newfoundland, Discipline Genet, St John, NF A1C 5S7, Canada.
    Wu, Anna H.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA.
    Wu, Xifeng
    Univ Texas MD Anderson Canc Ctr, Div Canc Prevent & Populat Sci, Dept Epidemiol, 1515 Holcombe Blvd, Houston, TX 77030 USA.
    Yannoukakos, Drakoulis
    Natl Ctr Sci Res Demokritos, Mol Diagnost Lab, INRASTES, Neapoleos 10, Athens 15310, Greece.
    Zheng, Wei
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, 1161 21st Ave S D3300, Nashville, TN 37232 USA.
    Zienolddiny, Shanbeh
    Natl Inst Occupat Hlth STAMI, Gydas Vei 8, N-0033 Oslo, Norway.
    Ziogas, Argyrios
    Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, 224 Irvine Hall, Irvine, CA 92617 USA.
    Zorn, Kristin K.
    Univ Pittsburgh, Womens Hosp, Sch Med, 300 Halket St, Pittsburgh, PA 15213 USA.
    Lane, Jacqueline M.
    Broad Inst MIT & Harvard, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA;Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA;Massachusetts Gen Hosp, Dept Anasthesia, Boston, MA 02114 USA.
    Saxena, Richa
    Broad Inst MIT & Harvard, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA;Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA;Massachusetts Gen Hosp, Dept Anasthesia, Boston, MA 02114 USA.
    Thomas, Duncan
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA.
    Hung, Rayjean J.
    Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Prosserman Ctr Populat Hlth Res, 60 Murray St, Toronto, ON M5T 3L9, Canada;Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, 155 Coll St, Toronto, ON M5T 3M7, Canada.
    Diergaarde, Brenda
    Univ Pittsburgh, Grad Sch Publ Hlth, Human Genet, UPMC Canc Pavil,Suite 4C,Off 467,5150 Ctr Ave, Pittsburgh, PA 15232 USA;UPMC Hillman Canc Ctr, Pittsburgh, PA 15232 USA.
    Mckay, James
    Int Agcy Res Canc, Genet Canc Susceptibil Grp, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Peters, Ulrike
    Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St, Seattle, WA 98195 USA.
    Hsu, Li
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA.
    Garcia-Closas, Montserrat
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Eeles, Rosalind A.
    Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England;Inst Canc Res, Oncogenet Team, Downs Rd, Sutton SM2 5NG, Surrey, England;Royal Marsden NHS Fdn Trust, Downs Rd, Sutton SM2 5NG, Surrey, England.
    Chenevix-Trench, Georgia
    QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, 300 Herston Rd, Brisbane, Qld 4006, Australia.
    Brennan, Paul J.
    Int Agcy Res Canc, Sect Genet, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Haiman, Christopher A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 48109 USA.
    Simard, Jacques
    Univ Laval, Res Ctr, Ctr Hosp Univ Quebec, Genom Ctr, 2705 Laurier Blvd, Quebec City, PQ G1V 4G2, Canada.
    Easton, Douglas F.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Gruber, Stephen B.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA.
    Pharoah, Paul D. P.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Price, Alkes L.
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA;Broad Inst MIT & Harvard, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA.
    Pasaniuc, Bogdan
    Univ Calif Los Angeles, UCLA Path & Lab Med, 10833 Le Conte Ave, Los Angeles, CA 19009 USA.
    Amos, Christopher I.
    Baylor Coll Med, Inst Clin & Translat Res, Epidemiol Sect, Dept Med, One Baylor Plaza,MS BCM451,Suite 100D, Houston, TX 77030 USA.
    Kraft, Peter
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA.
    Lindstrom, Sara
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St, Seattle, WA 98195 USA.
    Shared heritability and functional enrichment across six solid cancers2019Inngår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, artikkel-id 431Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

  • Dibitetto, Giuseppe
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik.
    Petri, Nicolo
    Bogazici Univ, Dept Math, TR-34342 Istanbul, Turkey.
    Surface defects in the D4-D8 brane system2019Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 1, artikkel-id 193Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A new class of exact supersymmetric solutions is derived within minimal d = 6 F(4) gauged supergravity. These flows are all characterized by a non-trivial radial profile for the 2-form gauge potential included into the supergravity multiplet. In particular three solutions within this class are featured by an AdS(3) foliation of the 6d background and by an AdS(6) asymptotic geometry. Secondly, considering the simplest example of these, we give its massive IIA uplift describing a warped solution of the type AdS(3) x S-2 x S-3 fibered over two intervals I-r x I. We interpret this background as the near-horizon of a D4-D8 system on which a bound state D2-NS5-D6 ends producing a surface defect. Finally we discuss its holographic dual interpretation in terms of a N = (0, 4) SCFT2 defect theory within the N = 2 SCFT5 dual to the AdS(6) x S-4 massive IIA warped vacuum.

  • Endres, Sonja
    et al.
    GEOMAR Helmholtz Ctr Ocean Res, Biol Oceanog, Kiel, Germany;Max Planck Inst Chem, Climate Geochem, Mainz, Germany.
    Maes, Frank
    Univ Ghent, Maritime Inst, Fac Law & Criminol, Ghent, Belgium.
    Hopkins, Frances
    Plymouth Marine Lab, Plymouth, Devon, England.
    Houghton, Katherine
    Inst Adv Sustainabil Studies, Potsdam, Germany.
    Mårtensson, E. Monica
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Luft-, vatten och landskapslära.
    Oeffner, Johannes
    Fraunhofer Ctr Maritime Logist & Serv, Hamburg, Germany.
    Quack, Birgit
    GEOMAR Helmholtz Ctr Ocean Res, Chem Oceanog, Kiel, Germany.
    Singh, Pradeep
    Univ Bremen, Ctr Marine Environm Sci, Bremen, Germany;Univ Bremen, Fac Law, Bremen, Germany.
    Turner, David
    Univ Gothenburg, Dept Marine Sci, Gothenburg, Sweden.
    A New Perspective at the Ship-Air-Sea-Interface: The Environmental Impacts of Exhaust Gas Scrubber Discharge2018Inngår i: Frontiers in Marine Science, E-ISSN 2296-7745, Vol. 5, artikkel-id 139Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Shipping emissions are likely to increase significantly in the coming decades, alongside increasing emphasis on the sustainability and environmental impacts of the maritime transport sector. Exhaust gas cleaning systems ("scrubbers"), using seawater or fresh water as cleaning media for sulfur dioxide, are progressively used by shipping companies to comply with emissions regulations. Little is known about the chemical composition of the scrubber effluent and its ecological consequences for marine life and biogeochemical processes. If scrubbers become a central tool for atmospheric pollution reduction from shipping, modeling, and experimental studies will be necessary to determine the ecological and biogeochemical effects of scrubber wash water discharge on the marine environment. Furthermore, attention must be paid to the regulation and enforcement of environmental protection standards concerning scrubber use. Close collaboration between natural scientists and social scientists is crucial for progress toward sustainable shipping and protection of the marine environment.

  • Bzowski, Adam
    et al.
    CEA Saclay, Inst Phys Theor, F-91191 Gif Sur Yvette, France.
    Guica, Monica
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik. CEA Saclay, Inst Phys Theor, F-91191 Gif Sur Yvette, France;Stockholm Univ, NORDITA, Roslagstullsbacken 23, S-10691 Stockholm, Sweden;KTH Royal Inst Technol, Roslagstullsbacken 23, S-10691 Stockholm, Sweden.
    The holographic interpretation of J¯T-deformed CFTs2019Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 1, artikkel-id 198Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Recently, a non-local yet possibly UV-complete quantum field theory has been constructed by deforming a two-dimensional CFT by the composite operator JT, where J is a chiral U(1) current and T is a component of the stress tensor. Assuming the original CFT was a holographic CFT, we work out the holographic dual of its JT deformation. We find that the dual spacetime is still AdS(3), but with modified boundary conditions that mix the metric and the Chern-Simons gauge field dual to the U(1) current. We show that when the coefficient of the chiral anomaly for J vanishes, the energy and thermodynamics of black holes obeying these modified boundary conditions precisely reproduce the previously derived field theory spectrum and thermodynamics. Our proposed holographic dictionary can also reproduce the field-theoretical spectrum in presence of the chiral anomaly, upon a certain assumption that we justify. The asymptotic symmetry group associated to these boundary conditions consists of two copies of the Virasoro and one copy of the U(1) Ka-Moody algebra, just as before the deformation; the only effect of the latter is to modify the spacetime dependence of the right-moving Virasoro generators, whose action becomes state-dependent and effectively non-local.

  • Heddini, Andreas
    et al.
    GSK, GSK Nord Cluster, Solna, Sweden.
    Sundh, Josefin
    Orebro Univ, Dept Resp Med, Sch Med Sci, Orebro, Sweden.
    Ekström, Magnus
    Lund Univ, Dept Clin Sci Lund Resp Med & Allergol, Lund, Sweden.
    Janson, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Effectiveness trials: critical data to help understand how respiratory medicines really work?2019Inngår i: European Clinical Respiratory Journal, ISSN 2001-8525, Vol. 6, nr 1, artikkel-id 1565804Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Most of the information about the benefits, safety aspects, and cost effectiveness of pharmacological treatment in the respiratory field has been obtained from traditional efficacy studies, such as randomised controlled trials (RCT). The highly controlled environment of an RCT does not always reflect everyday practice. The collection, analysis, and application of effectiveness data to generate Real World Evidence (RWE) through pragmatic trials or observational studies therefore has the potential to improve decision making by regulators, payers, and clinicians. Despite calls for more RWE, effectiveness data are not widely used in decision making in the respiratory field. Recent advances in data capture, curation, and storage combined with new analytical tools have now made it feasible for effectiveness data to become routine sources of evidence to supplement traditional efficacy data. In this paper, we will examine some of the current data gaps, diverse types of effectiveness data, look at proposed frameworks for the positioning of effectiveness data, as well as provide examples from therapeutic areas. We will give examples of both previous effectiveness studies and studies that are ongoing within the respiratory field. Effectiveness data hold the potential to address several evidentiary gaps related to the effectiveness, safety, and value of treatments in patients with respiratory diseases.

  • Carlie, Anne ()
    Skånska regioner: tusen år av kultur och samhälle i förändring2002Bok (Annet vitenskapelig)
  • Disputas: 2019-03-14 10:00 B242, STOCKHOLM
    Williamsson, David
    KTH, Skolan för industriell teknik och management (ITM), Maskinkonstruktion (Inst.).
    On integrated modularization for situated product configuration2019Licentiatavhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Road transports face increasing societal challenges with respect to emissions, safety, and traffic congestion, as well as business challenges. Truck automation, e.g. self-driving trucks may be utilized to address some of these issues. Autonomous transport vehicles may be characterized as Cyber-Physical Systems (CPS). A drawback is that CPS significantly increase technical complexity and thus introduce new challenges to system architecting.

    A product architecture is the interrelation between physical components and their function, i.e. their purpose. Product architectures can be categorized as being modular or integral. The main purpose of a modular architecture is to enable external variety and at the same time internal commonality. Products with a modular architecture are configured from predesigned building blocks, i.e. modules. A stable module, which is a carrier of main function(s) has standardized interfaces, is configured for company-specific reasons, which means it supports a company-specific (business) strategy.

    In this thesis, the present state at the heavy vehicle manufacturer Scania, concerning product architecting, modularization, product description and configuration is investigated. Moreover, a new clustering based method for product modularization that integrates product complexity and company business strategies is proposed. The method is logically verified with multiple industrial cases, where the architecture of a heavy truck driveline is used as a test bench. The driveline contains synergistic configurations of mechanical, electrical and software technologies that are constituents of an automated  and/or semi-autonomous system, i.e. the driveline may be characterized as a CPS. The architecture is analyzed both from technical complexity and business strategy point of view. 

    The presented research indicates that a structured methodology which supports the development of the product architecture is needed at Scania, to enable control of the increasing technical complexity in the Cyber-Physical Systems. Finally, configuration rules are identified to be highly important in order to successfully realize a modular product architecture. A drawback with this approach is that the solution space becomes hard to identify, therefore a complete and flexible product description methodology is essential. The results from the case studies indicate that clustering of a Product Architecture DSM may result in a modular architecture with significantly reduced complexity, but with clusters that contain conflicting module drivers. It is also identified that the new modularization methodology is capable of identifying and proposing reasonable module candidates that address product complexity as well as company-specific strategies. Furthermore, several case studies show that the proposed method can be used for analyzing and finding the explicit and/or implicit, technical as well as strategic, reasons behind the architecture of an existing product. 

  • Spade, Bengt
    De svenska vattenkraftverken: teknik under hundra år1999Bok (Annet vitenskapelig)
  • Bergman, Alexandra
    et al.
    Hellgren, John
    Moritz, Thomas
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Umeå Plant Science Centre (UPSC).
    Siewers, Verena
    Nielsen, Jens
    Chen, Yun
    Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae2019Inngår i: Microbial Cell Factories, ISSN 1475-2859, E-ISSN 1475-2859, Vol. 18, artikkel-id 25Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction: Phosphoketolases (Xfpk) are a non-native group of enzymes in yeast, which can be expressed in combination with other metabolic enzymes to positively influence the yield of acetyl-CoA derived products by reducing carbon losses in the form of CO2. In this study, a yeast strain expressing Xfpk from Bifidobacterium breve, which was previously found to have a growth defect and to increase acetate production, was characterized.

    Results: Xfpk-expression was found to increase respiration and reduce biomass yield during glucose consumption in batch and chemostat cultivations. By cultivating yeast with or without Xfpk in bioreactors at different pHs, we show that certain aspects of the negative growth effects coupled with Xfpk-expression are likely to be explained by proton decoupling. At low pH, this manifests as a reduction in biomass yield and growth rate in the ethanol phase. Secondly, we show that intracellular sugar phosphate pools are significantly altered in the Xfpk-expressing strain. In particular a decrease of the substrates xylulose-5-phosphate and fructose-6-phosphate was detected (26% and 74% of control levels) together with an increase of the products glyceraldehyde-3-phosphate and erythrose-4-phosphate (208% and 542% of control levels), clearly verifying in vivo Xfpk enzymatic activity. Lastly, RNAseq analysis shows that Xfpk expression increases transcription of genes related to the glyoxylate cycle, the TCA cycle and respiration, while expression of genes related to ethanol and acetate formation is reduced. The physiological and transcriptional changes clearly demonstrate that a heterologous phosphoketolase flux in combination with endogenous hydrolysis of acetyl-phosphate to acetate increases the cellular demand for acetate assimilation and respiratory ATP-generation, leading to carbon losses.

    Conclusion: Our study shows that expression of Xfpk in yeast diverts a relatively small part of its glycolytic flux towards acetate formation, which has a significant impact on intracellular sugar phosphate levels and on cell energetics. The elevated acetate flux increases the ATP-requirement for ion homeostasis and need for respiratory assimilation, which leads to an increased production of CO2. A majority of the negative growth effects coupled to Xfpk expression could likely be counteracted by preventing acetate accumulation via direct channeling of acetyl-phosphate towards acetyl-CoA.

  • Holmquist, Kersti
    Nordiska museet.
    En "collier de chien"1958Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1958, s. 214-216Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Disputas: 2019-03-15 09:00 Hörsal Betula, Umeå
    Haider, Zahra
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    DNA methylation signatures in precursor lymphoid neoplasms: with focus on clinical implications &  the biology behind2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Precursor lymphoid neoplasms, namely acute lymphoblastic leukemias (ALL) and lymphoblastic lymphomas (LBL), are characterized by an aggressive proliferation of malignant progenitor B- or T-cells. To improve risk classification at diagnosis, better prognostic and treatment stratifying biomarkers are needed. Altered DNA methylation pattern is a hallmark of neoplastic transformation, and has been employed as a molecular prognostic and predictive marker in various cancers, including hematological malignancies. Our research group previously identified a CpG island methylator phenotype (CIMP) panel that classified pediatric T-ALL patients into prognostic subgroups.

    The aim of this thesis was to evaluate distinct DNA methylation signatures in precursor lymphoid neoplasms, and to validate the prognostic value of CIMP classification in separate patient cohorts. Additionally, the biological mechanisms underlying the distinct CIMP methylation signatures in these malignancies were investigated.

    The prognostic relevance of CIMP classification was validated in an independent Nordic cohort of pediatric T-ALL patients. Combination of CIMP status with minimal residual disease (MRD) status, could further dissect the high-risk MRD positive T-ALL patients into two CIMP subgroups with significantly distinct outcomes. Furthermore, CIMP classification at diagnosis was shown to predict overall survival in relapsed BCP-ALL patients. CIMP methylation signatures were also identified in T-LBL patients, indicating a broader relevance of CIMP based classification in lymphoid malignancies. Investigating the biology behind CIMP methylation signatures showed the association of CIMP status with the proliferative history of the leukemic cells. A differential transcriptomic analysis revealed a correlation of CIMP subgroups with known T-ALL drivers, as well as with novel genes in T-ALL biology. Finally, we identified distinct DNA methylation patterns and genetic aberrations in T-ALL and T-LBL that might contribute to the different clinical presentation of these two diseases. In conclusion, we validated the prognostic significance of CIMP methylation signature in precursor lymphoid malignancies and identified transcriptomic profiles that associated with the subgroups. DNA methylation is a strong candidate for further risk classification in lymphoid neoplasms and our findings can contribute to the identification of new potential targets for treatment.

  • Disputas: 2019-03-22 09:00 Bergasalen, byggnad 27, Umeå
    Späth, Florentin
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Molecular epidemiology approach: nested case-control studies in glioma and lymphoid malignancies2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    BACKGROUND: Nested case-control studies aim to link molecular markers with a certain outcome. Repeated prediagnostic samples may improve the evaluation of marker-disease associations. However, data regarding the benefit of repeated samples in such studies are sparse. We aimed to assess the relationship between blood levels of various proteins and risk of glioma, B cell lymphoma, and multiple myeloma to gain further understanding of disease etiology and to evaluate the clinical relevance of the studied markers. To this end, marker-disease associations were evaluated considering the natural history of the studied disease and the time between blood sample collection and diagnosis using both single (I-II) and repeated prediagnostic blood samples (III-IV).

    PATIENTS AND METHODS: We conducted four nested case-control studies and one meta-analysis using samples from three prospective cohorts: the Janus Serum Bank, the Northern Sweden Health and Disease study, and the European Prospective Investigation into Cancer and Nutrition study. The following studied endpoints and relationships were included: I) glioma risk and the association with the receptor tyrosine kinases (soluble) sEGFR and sERBB2; II) B cell lymphoma risk and the association with the immune markers sCD27 and sCD30; III) B cell lymphoma risk and the association with immune markers (CXCL13, sTNF-R1, sCD23, sCD27, and sCD30) and their trends over time; and IV) multiple myeloma risk and the association  with ten immune markers and growth factors (MCP-3, MIP-1α, MIP-1β, VEGF, FGF-2, fractalkine, TGF-α, IL-13, TNF-α, and IL-10) and their trends over time.

    RESULTS: Risk of developing I) glioma was weakly associated with high blood levels of sERBB2. In addition, high levels of both sEGFR and sERBB2 assessed 15 years before diagnosis were associated with glioblastoma risk.

    Risk of II) B cell lymphoma was associated with high levels of sCD30, whereas high levels of sCD27 were particularly associated with risk of chronic lymphocytic leukemia. Meta-analyses showed consistent results for sCD30 across cohorts and lymphoma subtypes, whereas results for sCD27 were less consistent across cohorts and subtypes.

    In addition, III) B cell lymphoma risk was associated with levels of CXCL13, sCD23, sCD27, and sCD30 assessed in samples collected 17 years before diagnosis. Marker levels increased in cases closer to diagnosis, particularly for indolent lymphoma with a marked association for chronic lymphocytic leukemia and sCD23. Increasing marker levels closer to diagnosis were also observed for CXCL13 in future diffuse large B cell lymphoma patients.

    Risk of IV) multiple myeloma was associated with low levels of MCP-3, VEGF, FGF-2, fractalkine, and TGF-α. Levels of these markers decreased in myeloma cases over time, especially for TGF-α. TGF-α assessed at time of the prediagnostic repeated sample seemed to help predict progression to multiple myeloma.

    CONCLUSIONS: Both the natural history of the studied disease and the time between sample collection and diagnosis are crucial for the evaluation of marker-disease associations. Using repeated blood samples improves the understanding of marker-disease associations and might help to identify useful biomarker candidates.

  • Disputas: 2019-03-15 10:00 Carl Kempe salen (KB.E3.03), Umeå
    Ferro, Lorenza
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Wastewater treatment and biomass generation by Nordic microalgae: growth in subarctic climate and microbial interactions2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Nordic native microalgal strains were isolated, genetically classified and tested for their ability to grow in municipal wastewater. Eight of the isolated strains could efficiently remove nitrogen and phosphate in less than two weeks. Two of these strains, Coelastrella sp. and Chlorella vulgaris, were found to have high biomass concentration and total lipid content; also two Desmodesmus sp. strains showed desirable traits for biofuel-feedstock, due to their fast growth rates and high oil content.

    The adaptation to subarctic climate was comparatively evaluated in three Nordic strains (C. vulgaris, Scenedesmus sp. and Desmodesmus sp.) and a collection strain (S. obliquus). Their growth performance, biomass composition and nutrients removal was investigated at standard (25°C) or low temperature (5°C), under continuous light at short photoperiod (3 h light, 25°C) or moderate winter conditions (6 h light, 15°C). Only the Nordic strains could grow and produce biomass at low temperature, and efficiently removed nitrogen and phosphate during both cold- and dark-stress. Phenotypic plasticity was observed in Scenedesmus and Desmodesmus under different growth conditions, adaptation to low temperature increased their carbohydrate content. Short photoperiod strongly reduced growth rates, biomass and storage compounds in all strains and induced flocculation in C. vulgaris, which, however, performed best under moderate winter conditions.

    The symbiotic relationships between the Nordic microalga C. vulgaris and the naturally co-occurring bacterium Rhizobium sp. were investigated batchwise under photoautotrophic, heterotrophic and mixotrophic conditions, comparing the co-culture to the axenic cultures. The photoautotrophic algal growth in BG11 medium mainly supported Rhizobium activity in the co-culture, with no significant effects on C. vulgaris. In synthetic wastewater, a synergistic interaction only occurred under mixotrophic conditions, supported by CO2/O2 exchange and a lower pH in the culture, resulting in higher biomass and fatty acids content and more efficient wastewater treatment in the co-culture. Under heterotrophic conditions, the lower biomass production in the co-culture suggested a competition for nutrients, although nutrients removal remained efficient.

    A pilot-scale high rate algal pond (HRAP) located in Northern Sweden was inoculated with the collection strain Scenedesmus dimorphus UTEX 417 and operated from spring to autumn. Using metabarcoding of 18S and 16S rRNA genes, the microbial diversity of eukaryotic and prokaryotic communities was revealed. S. dimorphus was initially stable in the culture, but other microalgal species later colonized the system, mainly due to parasitic infections and predation by zooplankton in summer. The main competitor algal species were Desmodesmus, Pseudocharaciopsis, Chlorella, Characium and Oocystis. Proteobacteria, Firmicutes, Bacteroidetes and Actinobacteria were the most abundant bacterial phyla in the HRAP. The structure of the microbial communities followed a seasonal variation and partially correlated to environmental factors such as light, temperature and nutrients concentrations.

    Overall, these results contribute with new knowledge on the establishment and optimization of microalgal-based wastewater treatment systems coupled with biomass generation in Nordic areas. The use of native microalgal species is proposed as a potential strategy to overcome the limitations posed to algal cultivation in subarctic regions.

  • Eriksson, Thomas
    Kärl och social gestik: keramik i Mälardalen 1500 BC-400 AD2009Bok (Fagfellevurdert)
  • Cars, Göran
    et al.
    Olsson, Krister
    Snickars, Folke
    Kulturmiljö på spel: en studie av strategier att bevara och utveckla den byggda miljöns kulturvärden1996 (oppl. 1)Bok (Annet vitenskapelig)
  • Ängeby, Gisela
    1600-1700-talsarkeologi i kvarteret Björnen i Karlstad1995Bok (Annet vitenskapelig)
  • Gerdin, Anna-Lena
    Svärd och säd från bronsåldern samt mycket annat: om nya spännande fynd i Tanum1994 (oppl. 1)Bok (Annet vitenskapelig)
  • Magnus, Bente
    et al.
    Gustin, Ingrid
    Johansson, Lena
    Ragnarsson, Annika
    Birka och Hovgården2009Bok (Annet vitenskapelig)
  • Kindblom, Inga
    Badhus: bad och badande före 19501995 (oppl. 1)Bok (Annet vitenskapelig)
  • Löfgren, Håkan Löfgren
    Karlstads universitet, Estetisk-filosofiska fakulteten, Avdelningen för utbildningsvetenskap.
    Institutional memories in times of change: Institutionella minnen i tider av förändring2010Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    The over all aim for the project in which this paper is anchored is to investigate relationships between teachers’ identity constructions, conditions in local school contexts and changes in educational systems. In this paper I focus on how changes in the educational policy context relate to memories (re-) produced in a local context.  The specific aim of this paper is to show how discursive fragments and/or nested narrative types stand out in institutional memories in a local school context.When identities are analyzed time is an important factor, that’s why I consider institutional memories (Linde, 2009) an object of major interest in this study. These memories are known to everybody in the institution and they are constantly told and retold by it’s members. It is a working memory with influence on the identities produced in the institution. The content of institutional memories typically deals with turningpoints in the past, and the founder of the institution.  In times of change these memories serve as guides to future actions, but at the same time new aspects are added in the new versions of the memories. These aspects are characterized by narratives, or fragments of narratives, shaped in the time of the telling. In our time there is a substantial influence of private interests in the educational policy context. The new ‘meta’- narrative have been described as a marketization of the educational sector on all levels, with implications for teachers professional identities (Hargreaves, 2006). In this new educational ‘quasi’- market new and old actors meet in different ways in different places. This development put a new focal point on the localities where new narratives about education are told. In his description of exellent clusters Ball (2007) show how discursive fragments moves back and forth between governments and local innovation hot spots in the process of forming new narratives of ‘what works’. These fragments, as told by Ball, are pervaded by neo-liberal ideas. In my data I also trace other, less dominant, ‘meta’- narratives and to describe them I adopt the notion of ‘nested narrative types’ from Linde (2009). My intention in using this notion, is to describe those narratives about education that no longer have, or never have had, a dominant or hegemonic position, but still stands out in the institutional memories.   The empirical foundation in which this study is anchored is based on 15 lifehistory interviews conducted with 8 teachers who have been working at the same high school during two years or more. The school was recently shut down and the narratives of the teachers covers the 40-year period when the school was in use. All interviews have been transcribed in detail and screened for institutional memories. Different versions of the memories have been analyzed with respect to discursive fragments and nested narratives.Our results show that versions of institutional memories in a local school context offers different possibilities for teachers to position themselves in relation to different ‘meta’- narratives, or fragments of narratives, about education.

  • Disputas: 2019-03-13 13:00 Södrasalen, Hus M, Växjö
    Sjökvist, Tinh
    Linnéuniversitetet, Fakulteten för teknik (FTK), Institutionen för skog och träteknik (SOT).
    Coated Norway Spruce: Influence of Wood Characteristics on Water Sorption and Coating Durability2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Wood used outdoors is often degraded and discoloured by microorganisms as a natural part of its life cycle, particularly when exposed to high levels of moisture for prolonged times. In this case, the application of a coating (i.e. paint) is an option for increasing the service life of the wood.

    Norway spruce (Picea abies (L.) Karst.) is commonly used for outdoor applications in Sweden. Earlier studies have shown that uncoated spruce heartwood is less prone to moisture sorption in outdoor exposure, resulting in lower moisture content (MC) levels, as compared to sapwood. However, studies related to the above mentioned characteristics are rather limited for coated spruce, especially including the influence of outdoor exposure (i.e. weathering).

    The aim of this thesis is, therefore, to increase the knowledge of how heartwood and sapwood of different densities influence on the durability of coated Norway spruce for outdoor use. Different types of coatings with alkyd-, acrylic-, flour- (calcimine paint), or linseed-oil-based resin were included. The objectives were to study the water sorption (including MC variation) behaviour and crack formation of uncoated and coated heartwood and sapwood of different densities.

    Furthermore was an objective to study the microbial growth on the surface of similar samples of coated spruce in outdoor exposure. The used methods included wetting and liquid permeability experiments, accelerated water absorption (with samples floating freely in water), and outdoor field test. The field method lasted between three to five years and involved monitoring of the MC variation, the crack formation and the microbial growth on the samples.

    The results based on wetting measurements using octane as the adsorbed liquid showed no difference in liquid permeability between the spruce heartwood and sapwood samples of comparable densities, and indicated a similar level of pit aspiration (closure). The common flow path between two cells of conifers occurs through the pits. Still, the sapwood samples had in general a clearly higher water sorption rate than heartwood samples. It could be concluded that the increased sorption was presumably caused by a lowered water surface tension, most likely by a contamination effect of the water by surface-active sapwood extractives rather than differences in morphology of heartwood and sapwood.

    However, no clear difference in water absorption and MC levels was seen between coated heartwood and sapwood in the field study or in the accelerated water absorption study. Thus, it is suggested that a coating hinders the surfaceactive extractives to lower the water surface tension, resulting in a similar water absorption behaviour of coated heartwood and sapwood. The influence of density on water sorption of coated spruce was similarly to uncoated spruce, meaning the low-density samples had a higher MC than the high-density samples in the field tests. Furthermore, a one-year weathering of the coated and uncoated samples caused a larger increase in water sorption of high-density heartwood in the accelerated water absorption study.

    The field study on uncoated and calcimine-coated spruce showed a higher number of cracks on the high-density samples than on the low-density samples. Additionally, within each density group, a larger number of cracks were seen on sapwood samples as compared to heartwood samples. High-density samples with an alkyd- or an acrylic coating also showed a higher number of cracks. As expected, the formation of cracks on the samples increased their water sorption significantly. The microbial growth was higher on sapwood than on heartwood samples with a white coloured alkyd coating.

    The main conclusion is that heartwood and sapwood of different densities influence the water sorption and durability of coated Norway spruce. However, the principles in water sorption of uncoated heartwood and sapwood could not be applied to coated samples. Overall, the results point out that low-density heartwood could be the best material combination to improve the durability of coated spruce in outdoor use. The knowledge acquired in this thesis can enable an increased service life of coated spruce in outdoor use. The increase in service life is achieved by a careful selection of the wood material regarding the proportion of heartwood and to the choice of wood density. As a concluding remark, the role of surface-active spruce extractives needs to be explored, and a follow-up investigation in the context of water sorption is suggested for future research.

  • Larsson, Mats ()
    Olsson, Eva ()
    Regionalt och interregionalt: stenåldersundersökningar i Syd- och Mellansverige1997Bok (Annet vitenskapelig)