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  • Disputas: 2017-11-13 09:00 Kollegiesalen, Stockholm
    Fridlund, Gustav
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Utan tvivel är en inte klok: En studie om personliga skavningar som resurs för praktisk klokhet inom svensk kommunal planering2017Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    How can you as a planner tackle messy realities without losing sight of possible problematic outcomes of what you put in practice? This study explores the value of everyday frictions as a resource for phronetic planning, i.e. the ability to make situated ethical judements of what is ’better’ or ’worse’ in a particular setting. The intent is to offer a situated gaze of frictions from the perspective of a civil servant of the well organised and innovative municipality of Botkyrka in the metropolitan area of Stockholm, Sweden. From this outset, an autoethnographical methodology from a poststructural approach, is used to explore the frictions that the author has experienced as a practicing planner. The study shows that frictions can be used as 'weak signals' to identify possible tricky consequences of the creation and the staging of planning 'simplifications'. Based on this insight a 'seismological' approach to planning is proposed. The argument is that planning practice should on the one hand utilize frictions when they arise and, on the other hand, actively challenge existing 'simplifications'. To achieve this, practical tools are offered to 'evoke', 'narrate' and 'diffract' on frictions and 'trickster-objects' within the constraints of the planner’s role as a municipal civil servant. 

  • Asp, Petrus
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio historico-philosophica, de studio sapientum prisci ævi in eruditione comparanda; quam consensu ampliss. facult. philos. in regia academia Upsaliensi, publicæ bonorum disquisitioni sistunt auctor et præses Petrus M. Asp, O-Gothus, nec non respondens alumnus regius Nicolaus Paulin, Jemtius, in audit. Carol. maj. d. XIII. Martii, anni MDCCLVI. h. a. m. s.1756No name for locale no (Annet vitenskapelig)
  • Asp, Matthias
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Printz, Abraham
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio philosophica, de laude propria; quam, annuente amplissima facultat. philos. in regia acad. Upsal. præside ... Matthia Asp ... pro gradu, publico examini modeste submittit Abraham Printz, fil. Fierdhundrensis. In auditor. Gustav. major. d. XXVII Junii. Anni MDCCXXXVII. Horis ante meridiem solitis.1737No name for locale no (Annet vitenskapelig)
  • Asp, Matthias
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Exercitium academicum, de Sudercopia; cujus partem priorem, indultu amplissimi senatus philosophici, sub præsidio, ... Matthiæ Asp ... publice examinandam sistit Magnus Samuel Södersten, Sudercopia Oster-Gothus, in audit. Gust. maj. d. X Julii, anni MDCCXXXVI, horis solitis.1736No name for locale no (Annet vitenskapelig)
  • Asp, Matthias
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio academica de Nycopia metropoli Sudermanniæ; cujus partem priorem cum consensu ampliss. facult. philos. in reg. acad. Upsal., præside ... Matthia Asp ... publice ventilandam sistit alumnus Piperianus Johannes Sundler, Nycopia-Sudermannus. In audit Gust. maj. die 12 Junii an. MDCCXXXV, horis ante meridiem consvetis.1735No name for locale no (Annet vitenskapelig)
  • Asp, Matthias
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio de Lincopia; cujus partem priorem, cum consensu ampliss. senat. philosoph. in reg. acad. Upsaliensi, præside ... Matthia Asp ... publicæ ventilationi modeste submittit Johannes S. Ryding, Lincopia-Ostergothus, in audit. Gustav. maj. ad d. II. Junii anni MDCCXXXV. Horis ante meridiem solitis.1735No name for locale no (Annet vitenskapelig)
  • Asp, Matthias
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio academica, de societatibus literariis et scientiarum, præcipue hyperboreis, quam consensu ampliss. colleg. philos. ad almam academiam Upsaliensem, præside ... Matthia Asp ... ad publicum examen modeste defert Andreas Westén, And. fil. Ostro-Gothus. In audit. Gust. maj. die 20. Decembris, anni MDCCXXXIV. Horis ante meridiem consvetis.1734No name for locale no (Annet vitenskapelig)
  • Asp, Matthias
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio academica, de Medelpadia antiqua et hodierna; quam ... præside ... Matthia Asp ... publicæ censuræ modeste exhibet Carolus Jonæ Genberg Medelpadvs, in auditorio Carolin. majori ad d. XV. Junii, anno MDCCXXXIV.1734No name for locale no (Annet vitenskapelig)
  • Chen, Genqiang
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
    Wu, Guochao
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Alriksson, Björn
    Wang, Wei
    Hong, Feng F.
    Jönsson, Leif J.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Bioconversion of waste fiber sludge to bacterial nanocellulose and use for reinforcement of CTMP paper sheets2017Inngår i: Polymers, ISSN 2073-4360, E-ISSN 2073-4360, Vol. 9, nr 9, 458Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Utilization of bacterial nanocellulose (BNC) for large-scale applications is restricted by low productivity in static cultures and by the high cost of the medium. Fiber sludge, a waste stream from pulp and paper mills, was enzymatically hydrolyzed to sugar, which was used for the production of BNC by the submerged cultivation of Komagataeibacter xylinus. Compared with a synthetic glucose-based medium, the productivity of purified BNC from the fiber sludge hydrolysate using shake-flasks was enhanced from 0.11 to 0.17 g/(L x d), although the average viscometric degree of polymerization (DPv) decreased from 6760 to 6050. The cultivation conditions used in stirred-tank reactors (STRs), including the stirring speed, the airflow, and the pH, were also investigated. Using STRs, the BNC productivity in fiber-sludge medium was increased to 0.32 g/(L x d) and the DPv was increased to 6650. BNC produced from the fiber sludge hydrolysate was used as an additive in papermaking based on the chemithermomechanical pulp (CTMP) of birch. The introduction of BNC resulted in a significant enhancement of the mechanical strength of the paper sheets. With 10% (w/w) BNC in the CTMP/BNC mixture, the tear resistance was enhanced by 140%. SEM images showed that the BNC cross-linked and covered the surface of the CTMP fibers, resulting in enhanced mechanical strength.

  • Allgardsson, Anders
    et al.
    Andersson, C. David
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Akfur, Christine
    Worek, Franz
    Linusson, Anna
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Ekström, Fredrik
    An unusual dimeric inhibitor of acetylcholinesterase: cooperative binding of crystal violet2017Inngår i: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 22, nr 9, 1433Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Acetylcholinesterase (AChE) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. AChE is an important target for treatment of various cholinergic deficiencies, including Alzheimer's disease and myasthenia gravis. In a previous high throughput screening campaign, we identified the dye crystal violet (CV) as an inhibitor of AChE. Herein, we show that CV displays a significant cooperativity for binding to AChE, and the molecular basis for this observation has been investigated by X-ray crystallography. Two monomers of CV bind to residues at the entrance of the active site gorge of the enzyme. Notably, the two CV molecules have extensive intermolecular contacts with each other and with AChE. Computational analyses show that the observed CV dimer is not stable in solution, suggesting the sequential binding of two monomers. Guided by the structural analysis, we designed a set of single site substitutions, and investigated their effect on the binding of CV. Only moderate effects on the binding and the cooperativity were observed, suggesting a robustness in the interaction between CV and AChE. Taken together, we propose that the dimeric cooperative binding is due to a rare combination of chemical and structural properties of both CV and the AChE molecule itself.

  • Disputas: 2017-11-10 10:15 2446, Uppsala
    Sadanandan, Sajith Kecheril
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi, Avdelningen för visuell information och interaktion. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi, Bildanalys och människa-datorinteraktion. SciLifeLab.
    Deep Neural Networks and Image Analysis for Quantitative Microscopy2017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Understanding biology paves the way for discovering drugs targeting deadly diseases like cancer, and microscopy imaging is one of the most informative ways to study biology. However, analysis of large numbers of samples is often required to draw statistically verifiable conclusions. Automated approaches for analysis of microscopy image data makes it possible to handle large data sets, and at the same time reduce the risk of bias. Quantitative microscopy refers to computational methods for extracting measurements from microscopy images, enabling detection and comparison of subtle changes in morphology or behavior induced by varying experimental conditions. This thesis covers computational methods for segmentation and classification of biological samples imaged by microscopy.

    Recent increase in computational power has enabled the development of deep neural networks (DNNs) that perform well in solving real world problems. This thesis compares classical image analysis algorithms for segmentation of bacteria cells and introduces a novel method that combines classical image analysis and DNNs for improved cell segmentation and detection of rare phenotypes. This thesis also demonstrates a novel DNN for segmentation of clusters of cells (spheroid), with varying sizes, shapes and textures imaged by phase contrast microscopy. DNNs typically require large amounts of training data. This problem is addressed by proposing an automated approach for creating ground truths by utilizing multiple imaging modalities and classical image analysis. The resulting DNNs are applied to segment unstained cells from bright field microscopy images. In DNNs, it is often difficult to understand what image features have the largest influence on the final classification results. This is addressed in an experiment where DNNs are applied to classify zebrafish embryos based on phenotypic changes induced by drug treatment. The response of the trained DNN is tested by ablation studies, which revealed that the networks do not necessarily learn the features most obvious at visual examination. Finally, DNNs are explored for classification of cervical and oral cell samples collected for cancer screening. Initial results show that the DNNs can respond to very subtle malignancy associated changes. All the presented methods are developed using open-source tools and validated on real microscopy images.

  • Nestor, Bo
    Stockholms universitet, Lärarhögskolan i Stockholm (LHS), Institutionen för samhälle, kultur och lärande (SKL).
    ”Inte bara en kostnadsfråga” - ledningsgruppers tal om ”barn i behov”2005Rapport (Annet vitenskapelig)
    Abstract [en]

    In this study, I describe and analyze everyday talk about “special needs children” in the schools as the subject of conditioned negotiations in management meetings at the administrative level. The focus of the analysis is on the talk and interaction in the negotiation rounds that take place among meeting participants – particularly school superintendents and principals – in a continual negotiation from discovery of the problem until the administrative decision.

    My theoretical premise is based on discourse analysis, meaning that talk and text are seen as part of the social practice in which language is used to carry out or accomplish something. In the everyday talk they produce, people create order, meaning, and context in their reality. People jointly construct the world through everyday conversation, which also has an impact on how the world can be understood by individuals.

    The analytical point of departure is thus talk as action and interaction. I have applied a qualitative approach with tools from discourse analysis. I report and analyze conversation excerpts to show how the negotiation rounds ensue and how meeting participants process, negotiate, and renegotiate what they are talking about, what should be done about the matter at hand, and the import of the action. Order, meaning, and context are created in the meeting participants’ reality in the talk they produce and in the negotiation rounds. The study is a substudy of a research project “School management and administration as discourse and discursive practice – the leading words” (Sundgren, 2001), which is aimed at exploring the meaning of language as a tool for school management and administration in the political and administrative arenas.

  • Stenling, Roger
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap.
    The enterocyte in small intestinal adaption: an experimental and clinicopathological study with special reference to the ultrastructure of the brush border1984Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Stenling, Roger; THE ENTEROCYTE IN SMALL INTESTINAL ADAPTION. An expe­rimental and clinicopathological study with special reference to the ultrastructure of the brush border. Umeå Univ, Med Di ss, New Series 122 - ISSN 0346-6612.

    The small intestine mucosa is known to be able to adapt itself to several kinds of both physiological and pathological conditions. The adaptive patterns of the structure of the enterocytes, particularly their apical surface (brush border), were studied in three models: (1) in rats, subjected to antrectomy or antral exclusion, combined with gastroduodenostomy and gastrojejunostomy; (2) in rats with alloxan dia­betes; (3) in children with coeliac disease; a) in its active phase; b) after long-term treatment with gluten-free diets; c) after long-term challenge with dietary gluten following treatment; d) after short-term elimination of dietary gluten. Gut mucosa from fasting or fed, normal or sham-operated rats, fasting cats, and short-statured children with no signs of gastrointestinal disease served as controls. - The specimens were prepared for light microscopy (LM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Quantitation of structural variables was achieved by means of LM and TEM morphometrical procedures.

    Differentiation of the rat enterocytes from the base to the crest of the villi was structurally reflected by doubling of their apical cell area, an increase in cell height, and a decrease of both nuclear and mitochondrial volume densities. In mature normal rat enterocytes, high- -power SEM showed regularly arranged, nude microvilli in thir apical surfaces, whereas in cat and man the apical surfaces were covered by a thick glycocalyx. - Fasting for 24 hours decreased the total length of the rat small intestine and the height of the enterocytes. Antrectomy and antral exclusion with gastrojejunostomy produced an increase of the apical surfaces of the enterocytes of the seif-emptying duodenal blind loop, whereas no changes occurred after antrectomy with gastroduodeno­stomy. In the jejunum, the apical surface area was reduced both after antrectomy and antral exclusion. In the diabetic rats a slight decrease of the apical surface area, together with an elongation of both the vil­li and the crypts, was observed in the jejunum, whereas no structural changes occurred in the duodenal mucosa.

    Both in active coeliac disease and after long-term challenge with dietary gluten, SEM analyses showed uniformly destructed villi. The api­cal surfaces of the enterocytes were frequently convex and irregular in size and delineation (the surface of the normal enterocytes was polygo­nal and flat). Ultrastructurally, the apical surfaces were severely damaged with a distortion of the glycocalyx and with marked irregularity of the microvilli. - After gluten elimination, the surface ultrastructu­re of the enterocytes in the coeliac gut mucosa generally showed a rapid, clear-cut restoration despite a remaining severe atrophy of the villi. Successful dietary treatment (after about one year of gluten-free diet) restored the small intestine mucosa to normal as assessed both by LM and low-power SEM. In contrast, high-power SEM often disclosed per­sisting lesions of the enterocytes. Another provocation with gluten for up to 9 days in clinically healed coeliac mucosa did not significantly alter the surface ultrastructure of the enterocytes.

  • Björnstig, Ulf
    Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
    Snowmobile, motorcycle and moose-car accidents: aspects on injury control1985Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Injuries related to snowmobiles, motorcycles and moose-car collisions have increased. The aim of the present thesis was to analyse mechanisms and consequences in fatal and non-fatal accidents of these types, and to penetrate possible preventive measures.

    Snowmobiles

    The median age of the injured was 30 and of the killed 32, males pre­dominating. A majority of the accidents occurred during weekends, and especially the fatal accidents occurred after dark. The extremities were the most commonly injured parts of the body, however, drowning, crushed chest and cranial injuries caused most of the fatalities. Among the fatalities, four out of five were under the influence of alcohol. The present Swedish laws regarding snowmobiles seem well motivated. "Built-in" safety measures in the construction of the snowmobiles, pro­perly designed snowmobile tracks and functional search and rescue sys­tems could reduce the injuries.

    Motorcycles

    The median age was 19 years for both the traffic injured and the kil­led. Half of the traffic accidents were collisions with other motor ve­hicles. In the fatally injured group, also collisions with fixed road­side objects were common. Of the fatally injured, more than every fifth person died in an accident where alcohol was an influential factor. In the injured group, lower extremity injuries (especially in off-road riding) were common and among the fatalities most riders died from injuries to the head or chest. Out of one thousand motorcycle riders interviewed, 45% reported wobbling experiences (8% reported severe wobbling). Possible injury reducing measures include increasing the licensing age, more discriminating driving test, "built-in" restriction of the motorcycle's top speed, elimination of motorcycles prone to wobbling, and a more intensive traffic supervision (speeding, alco­hol).

    Moose-car collisitions

    The median age of the drivers was 38 years. Most collisions happened at dusk or when dark (3/4). The median collision speed was 70 km/h. The damage to the car was typical, the roof and the windshield pillars were deformed downwards and backwards. The broken windshield was often pressed into the passenger compartment. Most of the injured car occu­pants suffered cuts predominantly to the head and upper extremities. Nearly all the fatally injured died of head and neck injuries. The injuries may be reduced by strengthening the roof and the windshield pillars, and by introducing anti 1 acerati ve windshields.

  • Disputas: 2017-11-03 13:15 Wigforss, House J (Visionen), Halmstad
    Hoang, Le-Nam
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), Centrum för forskning om inbyggda system (CERES).
    Relaying for Timely and Reliable Applications in Wireless Networks2017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Many emerging applications based on wireless networks involve distributed control. This implies high requirements on reliability, but also on predictable maximum delay. Further, for applications, it is vital to use off-the-shelf components, both due to cost constraints and requirements on interoperability with existing networks. This, in turn, implies that concurrent transmissions and multiuser detection are seldom possible. Instead, half-duplex time-division multiple access (TDMA) is typically used. Aiming to reduce the packet error rate given a deadline (a set of TDMA time-slots), this thesis proposes a relaying scheme, which can be implemented on top of off-the-shelf components. The relaying scheme selects the best sequence of relayers, given the number of time-slots allowed by the deadline, such that the resulting error probability is minimized at the targeted receiver(s). The scheme differs from existing work in that it considers both unicast as well as broadcast and assumes that all nodes can overhear each other, as opposed to separating source nodes, relay nodes and destination nodes into three disjoint sets. A full analysis of the resulting error probability is provided and complementary numerical results show that the proposed relay sequencing strategy significantly improves reliability given a certain maximum delay, or alternatively, reduces the delay, given a certain target reliability requirement. To illustrate the performance improvements of relay sequencing, it is incorporated in a platooning application. If the decision regarding which relayer to assign in each time-slot can be taken online, just before the transmission, much can be gained. To this end, a low-complexity algorithm is developed, which is shown to be highly likely to find the optimal combination of relaying nodes that minimizes the resulting error probability at the targeted receiver(s). Data packets in wireless automation networks is typically small. To enable timely and reliable all-to-all broadcast in such systems, relay sequencing using packet aggregation is proposed. The strategy assigns relayers to time slots, as well as determines which packets to aggregate in each slot, using the proposed low-complexity algorithm. To further increase the reliability, a clustering scheme is proposed. When a relayer in the sequence fails to overhear a correct copy, a backup relayer in the cluster takes over. This work thereby enables ultra-reliable communications with maintained end-toend delay using low-complexity techniques and off-the-shelf components.

  • Garmy, Pernilla
    et al.
    Högskolan Kristianstad, Forskningsplattformen för Hälsa i samverkan. Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Sjuksköterskeutbildningarna. Högskolan Kristianstad, Forskningsmiljön Children's and Young People's Health in Social Context (CYPHiSCO).
    Andre, Bengt
    Läkemedelsverket.
    Anrsvik Malmberg, Kerstin
    Barn och ungdomspsykiatri Stockholm.
    Gullberg, Ninna
    Läkemedelsverket.
    Hägglöf, Bruno
    Umeå universitet.
    Sömnstörningar hos barn: kunskapsdokument2015Rapport (Annet vitenskapelig)
    Abstract [sv]

    Ett möte med experter på barns sömnproblem genomfördes i februari 2014 varvid detta kunskapsdokument togs fram. Kunskapssammanställningen och rekommendationerna har tagits fram gemensamt av experterna och bygger på konsensus bland deltagarna. Läkemedelsverkets ansvar var att facilitera mötet samt att tillsammans med experterna sammanställa kunskapsdokumentet. Som stöd för kunskapsdokumentet finns bakgrundsdokument som respektive författare ansvarar för. I bakgrundsdokumenten finns, förutom detaljerad information om varje ämnesområde, även referenser. Socialstyrelsen medverkade vid expertmötet, liksom i framtagandet av kunskapsdokumentet. Inför mötet har SBU (2013) identifierat kunskapsluckor inom området, vilka publicerats i SBU:s databas över vetenskapliga kunskapsluckor, se www.sbu.se. En vetenskaplig kunskapslucka innebär att systematiska litteraturöversikter saknas eller att de visar på osäker effekt. Man fann att detta gäller "Melatonin till barn som har flera funktionsnedsättningar och sömnproblem", "Melatonin som behandling av sömnproblem hos barn med adhd" och " Melatonin för i övrigt friska barn med sömnproblem". SBU konstaterade tidigare (2010) att "Effekten av alimemazin vid behandling av sömnbesvär" också är envetenskaplig  kunskapslucka.

  • Disputas: 2017-11-09 10:00 Vivi Täckholmsalen (Q-salen), NPQ-huset, Stockholm
    Gonska, Nathalie
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Proton pathways in energy conversion: K-pathway analogs in O2- and NO-reductases2017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Oxygen and nitric oxide reductases are enzymes found in aerobic and anaerobic respiration, respectively. Both enzyme groups belong to the superfamily of Heme-Copper Oxidases, which is further divided into several subgroups: oxygen-reducing enzymes into A-, B- and C-type and nitric oxide reductases into qNORs and cNORs. Oxygen reducing enzymes use the energy released from oxygen reduction to take up electrons and protons from different sides of the membrane. Additionally, protons are pumped. These processes produce a membrane potential, which is used by the ATP-synthase to produce ATP, the universal energy currency of the cell. Nitric oxide reductases are not known to conserve the energy from nitric oxide reduction, although the reaction is highly exergonic.

    Here, the detailed mechanism of a B-type oxidase is studied with special interest in an element involved in proton pumping (proton loading site, PLS). The study supports the hypothesis that the PLS is protonated in one and deprotonated in the consecutive step of the oxidative catalytic cycle, and that a proton is pumped during the final oxidation phase. It further strengthens the previous suggestion that the PLS is a cluster instead of a single residue or heme propionate. Additionally, it is proposed that the residue Asp372, which is in vicinity of the heme a3 propionates previously suggested as PLS, is part of this cluster. In another study, we show that the Glu15II at the entry of the proton pathway in the B-type oxidase is the only crucial residue for proton uptake, while Tyr248 is or is close to the internal proton donor responsible for coupling proton pumping to oxygen reduction.

    The thesis also includes studies on the mechanism and electrogenicity of qNOR. We show that there is a difference in the proton-uptake reaction between qNOR and the non-electrogenic homolog cNOR, hinting at a different reaction mechanism. Further, studies on a qNOR from a different host showed that qNOR is indeed electrogenic. This surprising result opens up new discussions on the evolution of oxygen and nitric oxide reductases, and about how energy conservation can be achieved.

  • Hålenius, Ulf
    et al.
    Naturhistoriska riksmuseet, Enheten för geovetenskap.
    Hatert, Frédéric
    Université de Liège, Belgium..
    Pasero, Marco
    Università di Pisa, Italy..
    Mills, Stuart J.
    Museum Victoria, Melbourne, Australia..
    IMA Commission on New Minerals, Nomenclature and Classification (CNMNC) Newsletter 392017Inngår i: Mineralogical magazine, ISSN 0026-461X, E-ISSN 1471-8022, Vol. 81, nr 5, 1279-1286 s.Artikkel i tidsskrift (Annet vitenskapelig)
  • Gren, Erik
    Uppsala universitet, Universitetsbiblioteket.
    Orientalia Suecana: Volume 41955Collection/Antologi (Fagfellevurdert)
  • Roos, Anna
    Naturhistoriska riksmuseet, Enheten för miljöforskning och övervakning.
    Fång, Johan
    Mätningar av läkemedelsrester i blod och urin från utter2017Rapport (Annet vitenskapelig)
  • Kinsman, John
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    de Bruijne, Kars
    Jalloh, Alpha M.
    Harris, Muriel
    Abdullah, Hussainatu
    Boye-Thompson, Titus
    Sankoh, Osman
    Jalloh, Abdul K.
    Jalloh-Vos, Heidi
    Development of a set of community-informed Ebola messages for Sierra Leone2017Inngår i: PLoS Neglected Tropical Diseases, ISSN 1935-2727, E-ISSN 1935-2735, Vol. 11, nr 8, e0005742Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The West African Ebola epidemic of 2013-2016 was by far the largest outbreak of the disease on record. Sierra Leone suffered nearly half of the 28,646 reported cases. This paper presents a set of culturally contextualized Ebola messages that are based on the findings of qualitative interviews and focus group discussions conducted in 'hotspot' areas of rural Bombali District and urban Freetown in Sierra Leone, between January and March 2015. An iterative approach was taken in the message development process, whereby (i) data from formative research was subjected to thematic analysis to identify areas of community concern about Ebola and the national response; (ii) draft messages to address these concerns were produced; (iii) the messages were field tested; (iv) the messages were refined; and (v) a final set of messages on 14 topics was disseminated to relevant national and international stakeholders. Each message included details of its rationale, audience, dissemination channels, messengers, and associated operational issues that need to be taken into account. While developing the 14 messages, a set of recommendations emerged that could be adopted in future public health emergencies. These included the importance of embedding systematic, iterative qualitative research fully into the message development process; communication of the subsequent messages through a two-way dialogue with communities, using trusted messengers, and not only through a one-way, top-down communication process; provision of good, parallel operational services; and engagement with senior policy makers and managers as well as people in key operational positions to ensure national ownership of the messages, and to maximize the chance of their being utilised. The methodological approach that we used to develop our messages along with our suggested recommendations constitute a set of tools that could be incorporated into international and national public health emergency preparedness and response plans.

  • Jons, Lotta
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för matematikämnets och naturvetenskapsämnenas didaktik.
    Learning in the Framework of Calling and Responsibiliy. 2011Konferansepaper (Fagfellevurdert)
  • Borg, Linda
    et al.
    Karlstads universitet, Universitetsbiblioteket.
    Dyrman, Ann
    Karlstads universitet, Universitetsbiblioteket.
    Åkerlund, Dan
    Karlstads universitet, Fakulteten för humaniora och samhällsvetenskap (from 2013), Institutionen för pedagogiska studier.
    Guide till Zotero2017Annet (Annet (populærvitenskap, debatt, mm))
  • Donnelly, Liam
    et al.
    UCD Forestry, University College Dublin, Ireland.
    Lundqvist, Sven-Olof
    RISE., Innventia.
    O'€™Reilly, Connor
    UCD Forestry, University College Dublin, Ireland.
    Inter-and intra-annual wood property variation in juvenile wood between six Sitka spruce clones2017Inngår i: Silva Fennica, ISSN 0037-5330, E-ISSN 2242-4075, Vol. 51, nr 4Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Increased growth rates have reduced rotation lengths, increasing the proportion of juvenile wood relative to mature wood, which may negatively affect mechanical performance of sawn timber. However, there is limited information available on the potential impact of breeding for vigour on juvenile wood in Sitka spruce (Picea sitchensis (Bong.) CarriÚre). In this study, the relationship between vigour (based on total height) and wood properties was investigated in six-year-old Sitka spruce clones grown in two replicated field trials in Ireland. Six clones were evaluated, two clones from each of three vigour (high, intermediate and low) classes. Discs were cut from the base of one ramet per replication for each clone to assess wood quality attributes. Radial tracheid width was significantly and positively correlated with ring width and height, and was negatively correlated with density. The wood of the most vigorous clone had significantly larger ring width with thinner cell walls and wider tracheids than all clones in the two other vigour classes, resulting in lower mean wood density. Latewood properties for all wood attributes measured differed significantly between the two sites. Wood property differences resulted primarily from variation in the proportions of early- and latewood in each annual ring. Additionally, the width of early- and latewood bands in each ring was found to be a more important determinant of juvenile wood quality than the characteristics of the cells within each band. Wood properties differed greatly between clones, suggesting that there is potential to improve juvenile wood properties through selective breeding.

  • Nilsson, Andreas
    Umeå universitet, Samhällsvetenskaplig fakultet, Handelshögskolan vid Umeå universitet.
    Projektledning i korta projekt: Observationer av projektledares arbete i multiprojektmiljö2004Licentiatavhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    As most of the project management models were developed for larger projects, there is a lack of understanding of what project managers in short duration projects do. Short-duration projects are projects in multi-project environments lasting for a number of weeks rather than a number of months. Even if they are common today, short-duration projects have not yet attracted the interest of project researchers. The present study aims to analyze what the project managers in short duration projects do and to develop a method for studying the project managers at work.

    A theoretical framework is built on earlier studies of managers’ work, suggesting three areas having impact on the project manager’s work. The impacting areas are the project, the project manager’s experience, and the organizational context of the project. The project manager and the assisting project manager were studied while managing a sub-project in a greater telecom system project. The project managers were studied one week each using participant observation and interviews. The findings indicate that much of the time at work was spent in meetings of different kinds, to deal with change, and to guard the production teams from being disturbed by changes in the environment. It was also found that studying a multi-project environment from the sub-project’s perspective gives a different view on multi-project environments that have earlier been presented as the project managers in the short-duration project constantly have to adjust to changes, inputs and demands from the surrounding projects and functional organizations. In the end some proposals on directions for further studies of managers of short-duration projects are made. 

  • Kremel, Anna
    Mälardalens högskola, Industriell ekonomi och organisation.
    Heterogeneity in the level and handling of the Liability of Newness: Female and immigrant entrepreneurs’ need for and use of business advisory service2017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    In the start-up entrepreneurs face the Liability of Newness when problems and challenges often threaten business survival. Business advisory service, provided by public and private supplier contacts, can offer important knowledge and information, accompanied by various forms of assistance, and thereby decrease the entrepreneurs’ risk of failure and reduce their Liability of Newness. However, it is difficult to match the entrepreneurs’ need for such advice with the available advice. The support must meet the need. Most nations in the European Union have programs and projects that provide such support for entrepreneurs and SMEs. Special programs often support female entrepreneurs and/or immigrant entrepreneurs.

    This thesis examines the level and handling of the Liability of Newness with special focus on female entrepreneurs and immigrant entrepreneurs in Sweden. The four papers of this thesis take the perspective of these entrepreneurs. The research is based on a sample of 2 832 entrepreneurs who were interviewed (in a telephone survey) on their impressions and recollections on their need for and use of business advisory service in the start-up processes of their companies. Fulfilment of need is achieved when the need for business advisory service is matched with the right use of business advisory service.

    Heterogeneities as far as the level and handling of the Liability of Newness exist related to female entrepreneurs (vs. male entrepreneurs) and immigrant entrepreneurs (vs. non-immigrant entrepreneurs). Female entrepreneurs have a higher need for business advisory service than male entrepreneurs and also use more business advisory service than male entrepreneurs. As a result, female entrepreneurs can decrease the hazard rate for their companies and also reduce the Liability of Newness as their companies move toward the standard risk in their industry. Immigrant entrepreneurs also have a higher need for business advisory service than non-immigrant entrepreneurs. However, because immigrant entrepreneurs use business advisory service to the same extent that non-immigrant entrepreneurs do, immigrant entrepreneurs are unable to decrease the hazard rate for their companies or to reduce the Liability of Newness.The thesis makes both theoretical, methodological and practical contributions.

    The thesis may be of interest to government policy makers with its attention to the need and use of business advisory service by female entrepreneurs and immigrant entrepreneurs.

  • Hansson, Oskar
    et al.
    Janelidze, Shorena
    Hall, Sara
    Magdalinou, Nadia
    Lees, Andrew J.
    Andreasson, Ulf
    Norgren, Niklas
    Linder, Jan
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap.
    Forsgren, Lars
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap.
    Constantinescu, Radu
    Zetterberg, Henrik
    Blennow, Kaj
    Blood-based NfL: A biomarker for differential diagnosis of parkinsonian disorder2017Inngår i: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 88, nr 10, 930-937 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To determine if blood neurofilament light chain (NfL) protein can discriminate between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally high diagnostic accuracy as CSF NfL, and can therefore improve the diagnostic workup of parkinsonian disorders. Methods: The study included 3 independent prospective cohorts: the Lund (n 5 278) and London (n 5 117) cohorts, comprising healthy controls and patients with PD, progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), as well as an early disease cohort (n 5 109) of patients with PD, PSP, MSA, or CBS with disease duration <= 3 years. Blood NfL concentration was measured using an ultrasensitive single molecule array (Simoa) method, and the diagnostic accuracy to distinguish PD from APD was investigated. Results: We found strong correlations between blood and CSF concentrations of NfL (p >= 0.73-0.84, p <= 0.001). Blood NfL was increased in patients with MSA, PSP, and CBS (i.e., all APD groups) when compared to patients with PD as well as healthy controls in all cohorts (p, 0.001). Furthermore, in the Lund cohort, blood NfL could accurately distinguish PD from APD (area under the curve [AUC] 0.91) with similar results in both the London cohort (AUC 0.85) and the early disease cohort (AUC 0.81). Conclusions: Quantification of blood NfL concentration can be used to distinguish PD from APD. Blood-based NfL might consequently be included in the diagnostic workup of patients with parkinsonian symptoms in both primary care and specialized clinics.

  • Andersson, Eva
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Kulturgeografiska institutionen.
    Malmberg, Bo
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Kulturgeografiska institutionen.
    Costa, Rafael
    Sleutjes, Bart
    Stonawski, Marcin Jan
    de Valk, Helga
    Comparative Study of Segregation Patterns in Belgium, Denmark, the Netherlands and Sweden: Neighbourhood Concentration and Representation of Non-European Migrants2017Rapport (Annet vitenskapelig)
    Abstract [en]

    In this paper we use geo-coded, individual level register data on four European countries to compute comparative measures of segregation that are independent of existing geographical sub- divisions. The focus is on non-European migrants, and using aggregates for egocentric neighbourhoods with different population counts, small-scale, medium-scale, and large-scale segregation patterns are assessed. At the smallest scale level, corresponding to neighbourhoods with 200 persons, patterns of over- and under-representation are strikingly similar. At larger scale levels, Belgium stands out as having relatively strong over- and under-representation. More than 55% of the Belgian population lives in large-scale neighbourhoods with moderate under- or over- representation of non-European migrants. In the other countries, the corresponding figures are between 30 % and 40%. Possible explanations for this pattern are differences in housing policies and refugee placement policies. Sweden has the largest and Denmark the smallest non-European migrant population, in relative terms. Thus, in both migrant-dense and native-born dense areas, Swedish neighbourhoods have a higher concentration, and Denmark a lower concentration of non- European migrants than the other countries. For large-scale, migrant-dense neighbourhoods, however, levels of concentration are similar in Belgium, the Netherlands, and Sweden. Thus, if this pattern is linked to a high concentration of disadvantaged population groups, it shows that these countries are facing similar policy challenges with respect to neighbourhood contexts. Contexts that can have negative effects on outcomes such as employment, income and education. 

  • Boris, Kapustin
    Yale University.
    Evil and freedom: Reflections regarding Kant’s ”Religion within the Boundaries of Mere Reason”2017Bok (Annet vitenskapelig)
    Abstract [en]

    The book aspires to show the inherent paradoxes of the “pure idea” of freedom and its foreignness, and possible contrariety, revealed in and by some specific historical-political contexts, to freedom as practice of human liberation. This theme is looked at mainly through the prism of Kant’s moral and political philosophy, which—by way of critical engagement with it—offers a particularly propitious vantage point for its exploration and elaboration. Kant’s Religion within the Boundaries of Mere Reason, with its dramatic juxtaposition and conjoining of freedom with evil, along with its emphasis on “radical evil” and, at the same time, its dismissal of “diabolic evil” (as something applicable to and practicable by humans) is particularly seminal in this respect. The book furnishes a political-philosophical reading of the paradoxes of Kant’s account of freedom and culminates in showing what they reveal and allow us to come to grips with politics in “real life”, in particular the politics of great revolutions.

  • Collin, Sven-Olof
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Ekonomi och arbetsliv. Högskolan Kristianstad, Forskningsmiljön Auditing, Organisation and Society (AOS). Högskolan Kristianstad, Forskningsmiljön Governance, Regulation, Internationalization and Performance (GRIP).
    Cooperation between university and society through research: the Kristianstad University research platform "Enterprising"2017Inngår i: Взаимодействие образовательных учреждений со стейкхолдерам: Веление времени / [ed] Astahova, E. V., Kharkiv: People's Ukranian Academy , 2017, 11-16 s.Kapittel i bok, del av antologi (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    In this paper I will discuss some issues concerning cooperation between academia and society in the context of the establishment of a cooperative research platform at Kristianstad University in Sweden. The platform aims at developing scientific knowledge and practical utility through cooperation between the university‟s resources, mainly its faculty, and practise in society, be it individuals or organizations, be it private, public or voluntary organisations.

  • Risso, Valeria A.
    et al.
    Univ Granada, Fac Ciencias, Dept Quim Fis, E-18071 Granada, Spain..
    Martinez-Rodriguez, Sergio
    Univ Granada, Fac Ciencias, Dept Quim Fis, E-18071 Granada, Spain..
    Candel, Adela M.
    Univ Granada, Fac Ciencias, Dept Quim Fis, E-18071 Granada, Spain..
    Krüger, Dennis M.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Struktur- och molekylärbiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Pantoja-Uceda, David
    CSIC, Inst Quim Fis Rocasolano, Dept Quim Fis Biol, C Serrano 119, E-28006 Madrid, Spain..
    Ortega-Munoz, Mariano
    Univ Granada, Fac Ciencias, Dept Quim Organ, E-18071 Granada, Spain..
    Santoyo-Gonzalez, Francisco
    Univ Granada, Fac Ciencias, Dept Quim Organ, E-18071 Granada, Spain..
    Gaucher, Eric A.
    Georgia Inst Technol, Sch Biol, Sch Chem & Biochem, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30322 USA..
    Kamerlin, Shina C. Lynn
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Struktur- och molekylärbiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Bruix, Marta
    CSIC, Inst Quim Fis Rocasolano, Dept Quim Fis Biol, C Serrano 119, E-28006 Madrid, Spain..
    Gavira, Jose A.
    Univ Granada, CSIC, Inst Andaluz Ciencias Tierra, Lab Estudios Cristalog, Ave la Palmeras 4, Granada 18100, Armilla, Spain..
    Sanchez-Ruiz, Jose M.
    Univ Granada, Fac Ciencias, Dept Quim Fis, E-18071 Granada, Spain..
    De novo active sites for resurrected Precambrian enzymes2017Inngår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, 16113Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Protein engineering studies often suggest the emergence of completely new enzyme functionalities to be highly improbable. However, enzymes likely catalysed many different reactions already in the last universal common ancestor. Mechanisms for the emergence of completely new active sites must therefore either plausibly exist or at least have existed at the primordial protein stage. Here, we use resurrected Precambrian proteins as scaffolds for protein engineering and demonstrate that a new active site can be generated through a single hydrophobic-to-ionizable amino acid replacement that generates a partially buried group with perturbed physico-chemical properties. We provide experimental and computational evidence that conformational flexibility can assist the emergence and subsequent evolution of new active sites by improving substrate and transition-state binding, through the sampling of many potentially productive conformations. Our results suggest a mechanism for the emergence of primordial enzymes and highlight the potential of ancestral reconstruction as a tool for protein engineering.

  • Namer, Barbara
    et al.
    Univ Erlangen Nurnberg, Dept Physiol & Pathophysiol, Erlangen, Germany.;Heidelberg Univ, Dept Anesthesiol, Mannheim, Germany..
    Ørstavik, Kirstin
    Oslo Univ Hosp, Sect Clin Neurophysiol, Dept Neurol, Rikshosp, Oslo, Norway..
    Schmidt, Roland
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Klinisk neurofysiologi.
    Mair, Norbert
    Med Univ Innsbruck, Div Physiol, Dept Physiol & Med Phys, Innsbruck, Austria..
    Kleggetveit, Inge Petter
    Oslo Univ Hosp, Sect Clin Neurophysiol, Dept Neurol, Rikshosp, Oslo, Norway..
    Zeidler, Maximillian
    Med Univ Innsbruck, Div Physiol, Dept Physiol & Med Phys, Innsbruck, Austria..
    Martha, Theresa
    Med Univ Innsbruck, Div Physiol, Dept Physiol & Med Phys, Innsbruck, Austria..
    Jorum, Ellen
    Heidelberg Univ, Dept Anesthesiol, Mannheim, Germany.;Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway..
    Schmelz, Martin
    Heidelberg Univ, Dept Anesthesiol, Mannheim, Germany..
    Kalpachidou, Theodora
    Med Univ Innsbruck, Div Physiol, Dept Physiol & Med Phys, Innsbruck, Austria..
    Kress, Michaela
    Med Univ Innsbruck, Div Physiol, Dept Physiol & Med Phys, Innsbruck, Austria..
    Langeslag, Michiel
    Med Univ Innsbruck, Div Physiol, Dept Physiol & Med Phys, Innsbruck, Austria..
    Changes in Ionic Conductance Signature of Nociceptive Neurons Underlying Fabry Disease Phenotype2017Inngår i: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 8, 335Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The first symptom arising in many Fabry patients is neuropathic pain due to changes in small myelinated and unmyelinated fibers in the periphery, which is subsequently followed by a loss of sensory perception. Here we studied changes in the peripheral nervous system of Fabry patients and a Fabry mouse model induced by deletion of a-galactosidase A (Gla(-/0)). The skin innervation of Gla(-/0) mice resembles that of the human Fabry patients. In Fabry diseased humans and Gla(-/0) mice, we observed similar sensory abnormalities, which were also observed in nerve fiber recordings in both patients and mice. Electrophysiological recordings of cultured Gla(-/0) nociceptors revealed that the conductance of voltage-gated Na+ and Ca2+ currents was decreased in Gla(-/0) nociceptors, whereas the activation of voltage-gated K+ currents was at more depolarized potentials. Conclusively, we have observed that reduced sensory perception due to small-fiber degeneration coincides with altered electrophysiological properties of sensory neurons.

  • Winblad, Ulrika
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Hälso- och sjukvårdsforskning.
    Blomqvist, Paula
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Statsvetenskapliga institutionen.
    Karlsson, Andreas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
    Do public nursing home care providers deliver higher quality than private providers?: Evidence from Sweden2017Inngår i: BMC Health Services Research, ISSN 1472-6963, E-ISSN 1472-6963, Vol. 17, 487Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Swedish nursing home care has undergone a transformation, where the previous virtual public monopoly on providing such services has been replaced by a system of mixed provision. This has led to a rapidly growing share of private actors, the majority of which are large, for-profit firms. In the wake of this development, concerns have been voiced regarding the implications for care quality. In this article, we investigate the relationship between ownership and care quality in nursing homes for the elderly by comparing quality levels between public, for-profit, and non-profit nursing home care providers. We also look at a special category of for-profit providers; private equity companies.

    Methods: The source of data is a national survey conducted by the Swedish National Board of Health and Welfare in 2011 at 2710 nursing homes. Data from 14 quality indicators are analyzed, including structure and process measures such as staff levels, staff competence, resident participation, and screening for pressure ulcers, nutrition status, and risk of falling. The main statistical method employed is multiple OLS regression analysis. We differentiate in the analysis between structural and processual quality measures.

    Results: The results indicate that public nursing homes have higher quality than privately operated homes with regard to two structural quality measures: staffing levels and individual accommodation. Privately operated nursing homes, on the other hand, tend to score higher on process-based quality indicators such as medication review and screening for falls and malnutrition. No significant differences were found between different ownership categories of privately operated nursing homes.

    Conclusions: Ownership does appear to be related to quality outcomes in Swedish nursing home care, but the results are mixed and inconclusive. That staffing levels, which has been regarded as a key quality indicator in previous research, are higher in publicly operated homes than private is consistent with earlier findings. The fact that privately operated homes, including those operated by for-profit companies, had higher processual quality is more unexpected, given previous research. Finally, no significant quality differences were found between private ownership types, i.e. for-profit, non-profit, and private equity companies, which indicates that profit motives are less important for determining quality in Swedish nursing home care than in other countries where similar studies have been carried out.

  • Stende, Truls
    Is the Nordic Region best in the world?2017Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    We often hear that the Nordic countries are at the top of one international index or another. International indices are lists ranking countries in a variety ofdifferent areas, such as inhabitants’ happiness or economic competitiveness. The number of indices and the attention they attract have increased markedlyin recent years, acquiring a significant degree of authority and legitimacy. Consequently the Nordic Council of Ministers’ policy analysis unit has studiedhow the Nordic Region would be ranked in some selected international indices if the region were one country.

    The indices we have looked at show that life in the Nordic Region is good. The region’s inhabitants are among the most prosperous in the world. There isconsiderable freedom of the press, and the region is one of the world’s least corrupt. Men and women enjoy greater equality than anywhere else on theplanet. And the region’s inhabitants are among the world’s happiest. That said, there is no certainty that the Nordic Region will retain its good rankings in theseindices. Like all other countries, the Nordic countries face major challenges in the years ahead. In order for life in the Nordic Region to remain good, the countriesmust maintain the mechanisms that support a high level of social capital, effective governance, and relatively egalitarian and equal societies.

    This report is written by the Nordic Council of Ministers' policy analysis unit. The report series will highlight relevant topics that are central from a Nordicperspective. This is the second report in the series. The first was ”Trust – the Nordic Gold”, which was published in spring 2017.

  • Larsson, Chatarina
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Ali, Muhammad Akhtar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Djureinovic, Tatjana
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Lindroth, Anders M.
    Natl Canc Ctr, Dept Syst Canc Sci, Grad Sch Canc Sci & Policy, 323 Ilsan Ro, Goyang Si 10408, South Korea..
    He, Liqun
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Vaskulärbiologi. Tianjin Med Univ, Gen Hosp, Dept Neurosurg,Minist Educ & Tianjin City, Tianjin Neurol Inst,Key Lab Postneuroinjury Neuro, Tianjin 300052, Peoples R China..
    Sjöblom, Tobias
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition2017Inngår i: BMC Cancer, ISSN 1471-2407, E-ISSN 1471-2407, Vol. 17, 487Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The disco-interacting protein 2 homolog C (DIP2C) gene is an uncharacterized gene found mutated in a subset of breast and lung cancers. To understand the role of DIP2C in tumour development we studied the gene in human cancer cells.

    Methods: We engineered human DIP2C knockout cells by genome editing in cancer cells. The growth properties of the engineered cells were characterised and transcriptome and methylation analyses were carried out to identify pathways deregulated by inactivation of DIP2C. Effects on cell death pathways and epithelial-mesenchymal transition traits were studied based on the results from expression profiling.

    Results: Knockout of DIP2C in RKO cells resulted in cell enlargement and growth retardation. Expression profiling revealed 780 genes for which the expression level was affected by the loss of DIP2C, including the tumour-suppressor encoding CDKN2A gene, the epithelial-mesenchymal transition (EMT) regulator-encoding ZEB1, and CD44 and CD24 that encode breast cancer stem cell markers. Analysis of DNA methylation showed more than 30,000 sites affected by differential methylation, the majority of which were hypomethylated following loss of DIP2C. Changes in DNA methylation at promoter regions were strongly correlated to changes in gene expression, and genes involved with EMT and cell death were enriched among the differentially regulated genes. The DIP2C knockout cells had higher wound closing capacity and showed an increase in the proportion of cells positive for cellular senescence markers.

    Conclusions: Loss of DIP2C triggers substantial DNA methylation and gene expression changes, cellular senescence and epithelial-mesenchymal transition in cancer cells.

  • Andersson, Peter
    et al.
    Institutionen för svenska språket, Göteborgs universitet.
    Holmberg, PerInstitutionen för svenska språket, Göteborgs universitet.Lyngfelt, AnnaInstitutionen för didaktik och pedagogisk profession, Göteborgs universitet.Nordenstam, AnnaInstitutionen för litteratur, idéhistoria och religion, Göteborgs univeristet / Institutionen för konst, kommunikation och lärande, Luleå Tekniska universitet.
    Mångfaldens möjligheter : litteratur- och språkdidaktik i Norden: Elfte nationella konferensen i svenska med didaktisk inriktning, Göteborg, 5-6 december 20132014Collection/Antologi (Annet vitenskapelig)
    Abstract [sv]

    Att göra olikheter till en poäng var utgångspunkten för 2013 års konferens. Det var därför som vi gick ut med uppmaningen att se och forska utifrån olika perspektiv i vår inbjudan till konferensen; vi önskade såväl metodologisk mångfald som intersektionella perspektiv för att utveckla den  ämnesdidaktiska forskning som rör skolämnena svenska, norska, danska och finländska. Konferensen, som ägde rum den 5 och 6 december 2013 i Göteborg utgjorde den fjärde nordiska konferensen i modersmålsdidaktik (NNMF 4) och den elfte konferensen i svenska med didaktisk inriktning (SMDI 11).

    Uppmaningen gav resultat. De svenska, norska, danska och finska forskningsbidragen som efter extern granskning och urval publiceras i Mångfaldens möjligheter. Litteratur- och språkdidaktik i Norden visar något av den bredd som finns inom språk- och litteraturdidaktisk forskning i Norden. Mångfaldstematiken framträder tydligast i den avdelning av volymen som fått rubriken ”Klassrummens mångfald”. Vad som här fokuseras är inte oväntat mångfalden av olika språk bland eleverna i Norden. De nordiska länderna har naturligtvis aldrig varit språkligt homogena områden, men det finns idag, inom såväl politik, pedagogisk profession som vetenskap, en bred samstämmighet om att undervisningen ska ta hänsyn till att en stor del av eleverna har andramodersmål än majoritetsspråket.

    Att undvika alla former av homogenisering när elever diskuteras framstår som centralt i sammanhanget. Flera av författarna riktar därför på mikronivå intresset mot vad som för enskilda elever får betydelse i deras möten med skolans språk- och litteraturundervisning. Detta kunskapsintresse låter sig väl förenas med undersökningar av den mångfald av texter, semiotiska resurser och digitala verktyg som elever med olika modersmål använder sig av för att skapa mening. Just den här dimensionen av mångfald understryks framförallt av de artiklarna i volymens inledande del, ”Texternas mångfald”.

    I volymens sista del, ”Mångfald i synsätt”, har några artiklar samlats som tillsammans lyfter fram den mångfald av olika forskningsperspektiv som ryms inom fältet svenska, norska och danska med didaktisk inriktning. Detta ska ses som en programförklaring: vi vill inte argumentera för samling kring ett enda forskningsparadigm utan istället uppmuntra till att fältets olika vetenskapstraditioner utvecklas såväl teoretiskt som metodologiskt. Ännu finns mycket kvar att utveckla genom en mångfald av samarbeten.

  • Stende, Truls
    Er Norden best i verden?2017Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [no]

    Man kan ofte lese om at nordiske land topper en eller annen internasjonal indeks. Internasjonale indekser er lister hvor land er rangert innenfor forskjellige temaer, som for eksempel innbyggernes lykke eller lands økonomiske konkurranseevne. Antallet indekser, og oppmerksomheten disse får, har økt kraftig de siste årene. De har oppnådd en betydelig autoritet og legitimitet. Nordisk ministerråds analyse- og utredningsenhet har derfor undersøkt hvor Norden ville plassert seg på noen utvalgte internasjonale indekser hvis Norden var et land.

    Indeksene vi har sett på, viser at det er godt å leve i Norden. Innbyggerne er blant de mest velstående i verden. Pressen er den frieste, og det er et av områdene i verden med minst korrupsjon. Kjønnene er mer likestilte enn noe annet sted.Og innbyggerne er blant de aller lykkeligste. Men det er selvfølgelig ikke gitt at Norden vil beholde de gode plasseringene på indeksene. De nordiske landene står, som alle andre land, overfor store utfordringer i årene fremover. For at det fortsatt skal være godt å leve i Norden, må landene opprettholde mekanismene som bidrar til at vi har en høy sosial kapital, et godt styresett og relativt egalitære og likestilte samfunn.

    Denne rapporten er skrevet av Nordisk ministerråds analyse- og utredningsenhet. Rapportserien skal belyse aktuelle emner som er sentrale i et nordisk perspektiv. Dette er den andre rapporten i serien. Den første var ”Tillid – det nordiske guld”, som ble utgitt våren 2017.

  • Langefeld, Carl D.
    et al.
    Wake Forest Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC 27101 USA.;Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27101 USA..
    Ainsworth, Hannah C.
    Wake Forest Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC 27101 USA.;Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27101 USA..
    Graham, Deborah S. Cunninghame
    Kings Coll London, Guys Hosp, Div Genet & Mol Med & Immunol Infect & Inflammato, London SE1 9RT, England..
    Kelly, Jennifer A.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Comeau, Mary E.
    Wake Forest Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC 27101 USA.;Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27101 USA..
    Marion, Miranda C.
    Wake Forest Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC 27101 USA.;Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27101 USA..
    Howard, Timothy D.
    Wake Forest Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC 27101 USA.;Wake Forest Sch Med, Ctr Human Genom & Personalized Med Res, Winston Salem, NC 27101 USA..
    Ramos, Paula S.
    Med Univ S Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA.;Med Univ South Carolina, Dept Med, Charleston, SC 29425 USA..
    Croker, Jennifer A.
    UAB Sch Med, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA..
    Morris, David L.
    Kings Coll London, Guys Hosp, Div Genet & Mol Med & Immunol Infect & Inflammato, London SE1 9RT, England..
    Sandling, Johanna K.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Univ Nacl Mayor San Marcos, Hosp G Almenara, Dept Reumatol, Lima 15081, Peru..
    Almlöf, Jonas Carlsson
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Univ Nacl Mayor San Marcos, Hosp G Almenara, Dept Reumatol, Lima 15081, Peru..
    Acevedo-Vasquez, Eduardo M.
    Univ Nacl Mayor San Marcos, Fac Med, Dept Reumatol, Lima 15081, Peru..
    Alarcon, Graciela S.
    Babini, Alejandra M.
    Hosp Italiano Cordoba, Cordoba, Argentina..
    Baca, Vicente
    Hosp Pediat Mexico City, Ctr Med Nacl Siglo XXI, Inst Mexicano Seguro Social, Mexico City 06720, DF, Mexico..
    Bengtsson, Anders A.
    Lund Univ, Dept Clin Sci, Rheumatol, S-22362 Lund, Sweden..
    Berbotto, Guillermo A.
    Hosp Eva Peron, Granadero Baigorria, Argentina..
    Bijl, Marc
    Martini Hosp, Dept Internal Med & Rheumatol, NL-9728 NT Groningen, Netherlands..
    Brown, Elizabeth E.
    Brunner, Hermine I.
    Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Rheumatol, Cincinnati, OH 45229 USA.;Univ Cincinnati, Cincinnati, OH 45229 USA..
    Cardiel, Mario H.
    Ctr Invest Clin Morelia, Morelia, Michoacan, Mexico..
    Catoggio, Luis
    Hosp Italiano Buenos Aires, RA-1181 Buenos Aires, DF, Argentina..
    Cervera, Ricard
    Univ Barcelona, Hosp Clin, Dept Autoimmune Dis, Barcelona 08007, Catalonia, Spain..
    Cucho-Venegas, Jorge M.
    Univ Nacl Mayor San Marcos, Fac Med, Dept Reumatol, Lima 15081, Peru..
    Dahlqvist, Solbritt Rantapaa
    Umea Univ, Dept Publ Hlth & Clin Med, Div Rheumatol, S-90187 Umea, Sweden..
    D'Alfonso, Sandra
    Univ Piemonte Orientale, Dept Hlth Sci & Inst Res Autoimmune Dis IRCAD, I-28100 Novara, Italy..
    Da Silva, Berta Martins
    Univ Porto, Inst Ciencias Biomed Abel Salaza, Unidade Multidisciplinar Invest Biomed, P-4099003 Oporto, Portugal..
    de la Rua Figueroa, Inigo
    Hosp Univ Gran Canaria Dr Negrin, Dept Rheumatol, Las Palmas Gran Canaria 35010, Spain..
    Doria, Andrea
    Univ Padua, Dept Med DIMED, Div Rheumatol, I-35122 Padua, Italy..
    Edberg, Jeffrey C.
    UAB Sch Med, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA..
    Endreffy, Emoke
    Univ Szeged, Fac Med, Albert Szent Gyorgyi Med Ctr, Dept Pediat, H-6720 Szeged, Hungary.;Univ Szeged, Fac Med, Albert Szent Gyorgyi Med Ctr, Child Hlth Ctr, H-6720 Szeged, Hungary..
    Esquivel-Valerio, Jorge A.
    Hosp Univ Dr Jose Eleuterio Gonzalez Univ Autonom, Monterrey 64020, Mexico..
    Fortin, Paul R.
    Univ Laval, CHU Quebec, Quebec City, PQ G1R 2JG, Canada..
    Freedman, Barry I.
    Wake Forest Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC 27101 USA.;Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27101 USA.;Wake Forest Sch Med, Sect Nephrol, Winston Salem, NC 27101 USA..
    Frostegard, Johan
    Karolinska Inst, Inst Environm Med, Unit Immunol & Chron Dis, S-17177 Stockholm, Sweden..
    Garcia, Mercedes A.
    Hosp Interzonal Gen Agudos Gen San Martin, Div Rheumatol, RA-1900 La Plata, Buenos Aires, Argentina..
    Garcia de la Torre, Ignacio
    Univ Guadalajara, Dept Fisiol, Guadalajara, Jalisco 44100, Mexico..
    Gilkeson, Gary S.
    Med Univ South Carolina, Dept Med, Charleston, SC 29425 USA..
    Gladman, Dafna D.
    Toronto Western Hosp, Krembil Res Inst, Ctr Prognosis Studies Rheumat Dis, Toronto, ON M5T 2S8, Canada..
    Gunnarsson, Iva
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Rheumatol Unit, S-17176 Stockholm, Sweden..
    Guthridge, Joel M.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Huggins, Jennifer L.
    Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Rheumatol, Cincinnati, OH 45229 USA.;Univ Cincinnati, Cincinnati, OH 45229 USA..
    James, Judith A.
    Hosp Eva Peron, Granadero Baigorria, Argentina.;Univ Oklahoma, Hlth Sci Ctr, Dept Med, Oklahoma City, OK 73104 USA.;Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK 73104 USA..
    Kallenberg, Cees G. M.
    Univ Med Ctr Groningen, Univ Groningen, Dept Rheumatol & Clin Immunol, NL-9713 GZ Groningen, Netherlands..
    Kamen, Diane L.
    Karp, David R.
    Univ Texas Southwestern Med Ctr Dallas, Dept Immunol, Dallas, TX 75235 USA..
    Kaufman, Kenneth M.
    Cincinnati Childrens Hosp Med Ctr, CAGE, Dept Pediat, Cincinnati, OH 45229 USA..
    Kottyan, Leah C.
    Cincinnati Childrens Hosp Med Ctr, CAGE, Dept Pediat, Cincinnati, OH 45229 USA..
    Kovacs, Laszlo
    Univ Szeged, Albert Szent Gyorgyi Med Ctr, Dept Rheumatol, H-6720 Szeged, Hungary..
    Laustrup, Helle
    Odense Univ Hosp, Dept Rheumatol, DK-5000 Odense, Denmark..
    Lauwerys, Bernard R.
    Catholic Univ Louvain, Clin Univ St Luc, Rheumatol, B-1348 Louvain La Neuve, Belgium.;Catholic Univ Louvain, Inst Rech Expt & Clin, B-1348 Louvain La Neuve, Belgium..
    Li, Quan-Zhen
    Univ Texas Southwestern Med Ctr Dallas, Dept Immunol, Dallas, TX 75235 USA..
    Maradiaga-Cecena, Marco A.
    Hosp Gen Culiacan, Sinaloa 80220, Mexico..
    Martin, Javier
    CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada 18100, Spain..
    McCune, Joseph M.
    Univ Michigan, Med Ctr, Ann Arbor, MI 48103 USA..
    McWilliams, David R.
    Wake Forest Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC 27101 USA.;Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27101 USA..
    Merrill, Joan T.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Miranda, Pedro
    Ctr Estudios Reumatol, Santiago 7500000, Chile..
    Moctezuma, Jose F.
    Hosp Gen Mexico City, Dept Reumatol, Mexico City 06726, DF, Mexico..
    Nath, Swapan K.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Niewold, Timothy B.
    Mayo Clin, Dept Rheumatol, Rochester, MN 94158 USA..
    Orozco, Lorena
    Inst Nacl Med Genom INMEGEN, Mexico City 14610, DF, Mexico..
    Ortego-Centeno, Norberto
    Hosp Univ San Cecilio, UGC Med Interna, Unidad Enfermedades Autoimmunes Sistem, Granada 18007, Spain..
    Petri, Michelle
    Johns Hopkins Univ, Sch Med, Dept Med, Div Rheumatol, Baltimore, MD 21218 USA..
    Pineau, Christian A.
    McGill Univ, Div Rheumatol, Montreal, PQ H3A 0G4, Canada..
    Pons-Estel, Bernardo A.
    Sanatorio Parque, Dept Rheumatol, Rosario, Santa Fe, Argentina..
    Pope, Janet
    Univ Western Ontario, London, ON M5T 2S8, Canada..
    Raj, Prithvi
    Univ Texas Southwestern Med Ctr Dallas, Dept Immunol, Dallas, TX 75235 USA..
    Ramsey-Goldman, Rosalind
    Northwestern Univ, Feinberg Sch Med, Div Rheumatol, Chicago, IL 60611 USA..
    Reveille, John D.
    Univ Texas Hlth Sci Ctr Houston UTHealth, Med Sch, Houston, TX 77030 USA..
    Russell, Laurie P.
    Wake Forest Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC 27101 USA.;Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27101 USA..
    Sabio, Jose M.
    Hosp Univ Virgen de las Nieves, Granada 18014, Spain..
    Aguilar-Salinas, Carlos A.
    Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metab, Vasco Quiroga 15, Mexico City 14080, DF, Mexico..
    Scherbarth, Hugo R.
    Autoinmunes HIGA Dr Alende Mar Plata, Unidad Reumatol & Enfermedades, Buenos Aires, DF, Argentina..
    Scorza, Raffaella
    Fdn IRCCS CaGranda Osped Ma Repiore Policlin, Referral Ctr Syst Autoimmune Dis, I-20122 Milan, Italy.;Univ Milan, I-20122 Milan, Italy..
    Seldin, Michael F.
    UC Davis Sch Med, Dept Biochem & Mol Med, Sacramento, CA 95616 USA..
    Sjowall, Christopher
    Linkoping Univ, Dept Clin & Expt Med, Rheumatol Div Neuro & Inflammat Sci, S-58183 Linkoping, Sweden..
    Svenungsson, Elisabet
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Rheumatol Unit, S-17176 Stockholm, Sweden..
    Thompson, Susan D.
    Cincinnati Childrens Hosp Med Ctr, CAGE, Dept Pediat, Cincinnati, OH 45229 USA..
    Toloza, Sergio M. A.
    Minist Hlth, Catamarca, Argentina..
    Truedsson, Lennart
    Lund Univ, Dept Lab Med, Sect Microbiol Immunol & Glycobiol, S-22100 Lund, Sweden..
    Tusie-Luna, Teresa
    UNAM Inst Nacl Ciencias Med & Nutr Salvador Zubir, Inst Invest Biomed, Unidad Biol Mol & Med Genom, Mexico City 14080, DF, Mexico..
    Vasconcelos, Carlos
    Univ Porto, Hosp Santo Antonio, P-4099003 Oporto, Portugal..
    Vila, Luis M.
    Univ Puerto Rico, Sch Med, San Juan, PR 00936 USA..
    Wallace, Daniel J.
    Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA..
    Weisman, Michael H.
    Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA..
    Wither, Joan E.
    Toronto Western Hosp, Krembil Res Inst, Ctr Prognosis Studies Rheumat Dis, Toronto, ON M5T 2S8, Canada..
    Bhangale, Tushar
    Genentech Inc, Human Genet, South San Francisco, CA 94080 USA..
    Oksenberg, Jorge R.
    Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA.;Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94158 USA..
    Rioux, John D.
    Univ Montreal, Montreal, PQ H1T 1C8, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada..
    Gregersen, Peter K.
    Feinstein Inst Med Res, Ctr Genom Human Genet, Manhasset, NY 11030 USA..
    Syvänen, Ann-Christine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Univ Nacl Mayor San Marcos, Hosp G Almenara, Dept Reumatol, Lima 15081, Peru..
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Criswell, Lindsey A.
    UCSF Sch Med, Rosalind Russell Ephraim P Engleman Rheumatol Res, Div Rheumatol, San Francisco, CA 94158 USA..
    Jacob, Chaim O.
    Keck Sch Med USC, Los Angeles, CA 90033 USA..
    Sivils, Kathy L.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Tsao, Betty P.
    Med Univ South Carolina, Dept Med, Charleston, SC 29425 USA..
    Schanberg, Laura E.
    Duke Univ, Dept Pediat, Durham, NC 27708 USA..
    Behrens, Timothy W.
    Genentech Inc, Human Genet, South San Francisco, CA 94080 USA..
    Silverman, Earl D.
    Hosp Sick Children, Res Inst, Dept Pediat, Toronto, ON M5G 1X8, Canada.;Hosp Sick Children, Res Inst, Inst Med Sci, Toronto, ON M5G 1X8, Canada.;Univ Toronto, Toronto, ON M5G 1X8, Canada..
    Alarcon-Riquelme, Marta E.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA.;Univ Granada, Pfizer, Junta De Andalucia Ctr Genom & Oncol Res GENYO, Granada 18007, Spain.;Karolinska Inst, Unit Inst Environm Med, S-17177 Solnavagen, Sweden..
    Kimberly, Robert P.
    UAB Sch Med, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA..
    Harley, John B.
    Cincinnati Childrens Hosp Med Ctr, CAGE, Dept Pediat, Cincinnati, OH 45229 USA..
    Wakeland, Edward K.
    Univ Texas Southwestern Med Ctr Dallas, Dept Immunol, Dallas, TX 75235 USA..
    Graham, Robert R.
    Genentech Inc, Human Genet, South San Francisco, CA 94080 USA..
    Gaffney, Patrick M.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Vyse, Timothy J.
    Kings Coll London, Guys Hosp, Div Genet & Mol Med & Immunol Infect & Inflammato, London SE1 9RT, England..
    Transancestral mapping and genetic load in systemic lupus erythematosus2017Inngår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, 16021Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P < 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE.

  • Chrystal, Judith-Ann
    et al.
    Institutionen för svenska och flerspråkighet, Stockholms universitet.
    Lim Falk, MariaInstitutionen för svenska och flerspråkighet, Stockholms universitet.Hedman, ChristinaInstitutionen för språkdidaktik, Stockholms universitet.Josephson, OlleInstitutionen för svenska och flerspråkighet, Stockholms univeristet.Öhrn, MagnusBarn- och ungdomsvetenskapliga institutionen, Centrum för barnkulturforskning, Stockholms univeristet.
    Tionde nationella konferenseni svenska med didaktisk inriktning, Stockholm 18–19 oktober 2012: Genre2013Collection/Antologi (Annet vitenskapelig)
    Abstract [sv]

    Tionde nationella konferensen i svenska med didaktisk inriktning (SMDI) hölls på Stockholms universitet i oktober 2012. Som värdar för konferensen stod Institutionen för litteraturvetenskap och idéhistoria, Institutionen för nordiska språk samt Institutionen för språkdidaktik. Konferensens tema var Genre och omfattade litteraturvetenskapliga, litteraturdidaktiska, språkvetenskapliga och språkdidaktiska perspektiv. Programmet uppmärksammade också att årets konferens var den tionde konferensen i svenska med didaktisk inriktning sedan konferensserien inleddes 2003 i Växjö. Den första konferensen var i första hand ett forum där de nya doktoranderna i Nationella forskarskolan i svenska med didaktisk inriktning presenterade sina forskningsprojekt. Forskningsfältet har vuxit och vidgats sedan dess. Den tionde konferensen samlade 135 deltagare huvudsakligen från Sverige men även från våra grannländer. Programmet innehöll fyra plenarföredrag och 33 sektionsföredrag. Ett urval av de inskickade abstracten antogs efter att ha genomgått en anonym granskningsprocess.

    Två av de inbjudna plenarföreläsarna belyste konferensens tema. John Polias från The Hong Kong Polytechnic University inledde konferensen med ett föredrag om tilllämpning av genrepedagogik: Perspectives from the classroom on genre and genrebased pedagogy and specifically the temporal explanation genre i science classrooms. Konferensens andra dag inleddes av Christian Mehrstam från Högskolan Väst som i ett genreteoretiskt perspektiv diskuterade läroplansskrivningar och studenters litteraturtolkning i sitt plenarföredrag Klassifikation, analys eller kulturell omförhandling? Den enskilda läspraktikens förhållande till genre.

    De två återstående plenarföredragen utgick från jubileumstemat. Caroline Liberg, Uppsala universitet, blickade tillbaka på hur forskningen inom svenska med didaktisk inriktning har utvecklats de senaste tio åren i föredraget Plogen i forskningsfältet: Nätverket Svenska med didaktisk inriktning. Christina Olin-Scheller, Karlstads universitet, avslutade konferensen med föredraget Multimodalitet, medier och metoder – utmaningar och möjligheter för SMDI som forskningsfält. Hon behandlade möjligheter och utmaningar som fältet står inför.

    I denna konferensvolym återfinns artiklar från två av plenarföreläsarna, Christian Mehrstam och Christina Olin-Scheller. En version av Caroline Libergs anförande är publicerad i Svensklärarföreningens årsskrift 2012. Tretton av sektionsföredragshållarna har valt att återge sina bidrag i artikelform.

  • Magnusson, Jenny
    et al.
    Institutionen för kultur och lärande, Lärarutbildningen, Södertörns högskola.
    Malmbjer, AnnaInstitutionen för kultur och lärande, Södertörns högskola.Wojahn, DanielInstitutionen för kultur och lärande, Södertörns högskola.
    Åttonde nationella konferensen i svenska med didaktisk inriktning, Södertörns högskola 25–26 november 2010: Språket, kroppen och rummet – multimodala och digitala perspektiv på lärande2011Collection/Antologi (Fagfellevurdert)
    Abstract [sv]

    Åttonde nationella konferensen i svenska med didaktisk inriktning hölls på Södertörns högskola i november 2010. Temat för konferensen var Språket, kroppen och rummet – multimodala och digitala perspektiv på lärande. Konferensen samlade ungefär 140 deltagare och innehöll fyra plenarföredrag, trettiotvå sektionsföredrag och en forskningsstrategisk paneldiskussion om de nya kurs- och ämnesplanernas styrande funktion.

    De många presentationerna gav spännande och nya perspektiv på multimodalt och digitalt lärande i förskolan, hela grundskolan, gymnasiet, vuxenutbildningen och i vardagen och visade på bredden i forskningsfältet och på didaktiska möjligheter och utmaningar. De flesta presentationer behandlade barn och ungas produktion och användning av multimodala uttrycksformer, som film, bilder och digitala texter men även pappersburet skrivande och läsande inom olika genrer. Några presentationer problematiserade bedömningen av elevers multimodala och digitala kompetens och arbeten. Andra presentationer tog upp innehåll i och framställning av läromedel. Ytterligare andra förde en kritisk eller filosofisk diskussion om skriftens överlägsenhet, det skrivande barnet och läsandets rum.

    De fyra inbjudna plenarföreläsarna belyste konferensens tema utifrån aktuella forskningsprojekt. Elise Seip Tønnessen från universitetet i Agder utgick från projektet Multimodalitet, leseopplæring og læremidler och talade om ämnet Å lese og lære fra multimodal tekst. Charlotte Engblom från högskolan i Gävle talade om Barns skärmbaserade texthantering. Sammansatta texter och nya perspektiv på progression och bedömning med utgångspunkt i projektet Skilda världar? Texthantering hemma som resurs för lärande i skolan. Asta Cekaite Thunqvists, Linköpings universitet, föredrag hade titeln Multimodalitet ur ett andraspråksperspektiv: kroppsliga aspekter av kommunikation, undervisning och lärande och utgick från projektet Känslouttryck och informellt lärande i flerspråkiga klassrum. Patrik Hernwall, Södertörns högskola, avslutade konferensen med föredraget Digitala medier och ungas multimodala uttryck – nya möjligheter att skapa text utifrån projektet Ungas multimodala gestaltning – hur digitala medier kan användas för uttryck och reflektion.

    Två av plenarföreläsarna bidrar med artiklar. Elise Seip Tønnessen resonerar om skolstarten, skolans textkultur och barns naturliga multimodala utgångspunkt. Charlotte Engblom diskuterar det läsande och skrivande i vid bemärkelse som yngre barn ägnar sig åt i hemmiljö och i skolmiljö, främst via datorn, och hur det kan förstås utifrån en sociosemiotisk syn på texthantering.

    Här följer artiklarna från två av plenarföreläsningarna och ett urval av sektionsföredragen i bokstavsordning efter skribenternas namn. I en första avdelning har skribenternas sammanfattningar av artiklarna samlats.

  • Stiernstedt, Fredrik
    Södertörns högskola, Institutionen för kultur och lärande, Medie- och kommunikationsvetenskap. Södertörns högskola, Centrum för Östersjö- och Östeuropaforskning (CBEES), Baltic & East European Graduate School (BEEGS).
    The Sustainability of Native Advertising: Organizational Perspectives on the Blurring of the Boundary Between Editorial and Commercial Content in Contemporary Media.2017Inngår i: What is Sustainable Journalism?: Integrating the Environmental, Social and Economic Challenges of Journalism / [ed] Peter Berglez, Ulrika Olausson & Mart Ots, New York: Peter Lang Publishing Group, 2017, 277-295 s.Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Adelmann, Kent
    Lärarutbildningen, Malmö högskola.
    Sjunde nationella konferensen i Svenska med didaktisk inriktning, Malmö 18-20 november 2009: Att bygga broar –kulturella, språkliga och mediala möten2010Collection/Antologi (Annet vitenskapelig)
    Abstract [sv]

    Den här konferensen pekar på en enastående utveckling och utvecklingspotential för SMDI. Svenska med didaktisk inriktning kan numera betraktas som ett etablerat forskningsområde och har ett nära samarbete med motsvarande systerorganisationer i Danmark (Netværk for forskning i dansk-fagenes didaktik, DaDi) och Norge (Nettverk for norskdidaktisk forskning, NNDF). Konferensen i Malmö samlade 174 deltagare från de nordiska länderna och innehöll fyra plenarföredrag samt 49 sektionsföredrag, vilket visar både styrka och bredd.

    De 15 bidrag som presenteras i den här forskningsrapporten omfattar de fyra plenarföreläsningarna (av Jens Elmelund Kjeldsen, Caroline Liberg, Kathleen McCormick och Jon Smidt) samt elva av sektionsföredragen. Texterna handlar om många olika slags möten. Det kan gälla kulturella möten i det heterogena klassrummet (McCormick) eller i de nordiska kursplanernas språk- och litteraturundervisning (Hägerfelth & Skarstein). Och det kan gälla språkliga möten med lyssningens ABC (Adelmann) eller med postmoderna läromedel mellan tradition och fönyelse (Dahl). Eller mediala möten med de mediekulturella förändringarnas konsekvenser för läsreceptionen (Elmfeldt & Persson). Men även krockar, mellan mediering via PowerPoint eller retorik (Kjeldsen).

    Här finns svenskämnets territoriella utbredning i mötet med den moderna ungdomsskolan (Martinsson). Och här finns de lärarstuderandes möte med skolverkligheten (Östlundh) och elevernas möte med nationella prov i årskurs 3 (Borgström & Yassin). Eller lärarens möte med olika  skrivutvecklingsperspektiv på yrkesinrikade gymnasieprogram (Westman), seriernas potential i svenskundervisningen (Mehrstam) eller olika didaktiska läsarter (Bringéus). Och här byggs det broar mellan modersmålsskrivande och skrivande i alla andra ämnen (Smidt), och mellan en språkbaserad ämnesundervisning och en ämnesbaserad språkundervisning (Liberg). Men det varnas också för faran med bro-metaforen, som kan konstruera kulturella olikheter istället för att konstruera mening som bygger på våra likheter (Penne).

  • Rönn Emsfors, Åsa
    et al.
    Central Hospital Kristianstad.
    Elgán, Carina
    Högskolan Kristianstad, Sektionen för hälsa och samhälle, Avdelningen för Sjuksköterskeutbildningarna. Högskolan Kristianstad, Forskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Högskolan Kristianstad, Forskningsplattformen för Hälsa i samverkan.
    Patients' experiences of nursing actions during intravitreal treatment for wet age-related macular degeneration2015Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    Purpose: The aim was to identify and describe nursing actions performed by nursing staff in which patients with wet age-related macular degeneration (AMD) experience good nursing care.

    Method: An explorative and descriptive qualitative design based on the Critical incident technique (CIT) was used. A strategic sample of 16 patients, aged 61-87 years (eleven women and five men) with wet AMD who received intravitreal treatment were interviewed.

    Results: Two main areas of good nursing care was identified during intravitreal treatment Being perceived as an individual and Creating confidence during visits, each area contained two categories. The two categories in the area Being perceived as an individual were; acting respectfully and being engaged. Acting respectfully was perceived when the nursing staff had a benevolent attitude and answered questions kindly and polite. The patients considered to be seen as an individual when the nursing staff were available for conversation and were present. The two categories in the area Creating confidence during visits were; encourage participation and inspiring confidence. Encouraging participation was perceived when the nursing staff continuously provided information. The nursing staff created confidence and trust by keeping promises and being honest.

    Conclusion: The interaction in the encounter between patient and caregiver is fundamental for patients' experience of good nursing care. It emphasise the importance of personal centred care even though the time for each patient is limited and the nursing staff have a demanding schedule. It would be desirable with specific guidelines for care of patient who gets intravitreal treatment. Without specific guidelines makes it difficult to implement person centred care and more quality time would benefit the patient.

                                                                                                   

  • Palmér, Anne
    et al.
    Institutionen för nordiska språk, Uppsala universitet.
    Fast, CarinaInstitutionen för didaktik, Uppsala univeristet.Kåreland, LenaInstitutionen för didaktik och Litteraturvetenskapliga institutionen, Uppsala universitet.Östlund-Stjärnegårdh, EvaInstitutionen för nordiska språk, Uppsala universitet.
    Sjätte nationella konferensen i svenska med didaktisk inriktning: Muntlighetens möjligheter – retorik, berättande, samtal, Uppsala den 27–28 november 20082009Collection/Antologi (Annet vitenskapelig)
    Abstract [sv]

    Den sjätte konferensen i serien Svenska med didaktisk inriktning hölls i Uppsala i november 2008. Temat för konferensen – liksom för denna volym – var Muntlighetens möjligheter – retorik, berättande, samtal. De många presentationerna visade att ämnet hade inspirerat forskare med olika inriktningar, teoretiska och empiriska, retoriska och samtalsinriktade, språk- och litteraturdidaktiska med flera. Bidrag som låg utanför temat var också  välkomna och ett par sådana finns representerade i denna volym.

    Två av konferensens plenartalare bidrar med artiklar. Mads Th. Haugsted från Århus universitet resonerar om muntlighet i undervisning kontra undervisning i muntlighet. Medan muntlighet i undervisning framför allt är ett redskap för  att nå olika allmändidaktiska, litteratur-, medie och skrivpedagogiska mål, handlar undervisning i muntlighet om själva det muntliga uttrycket.  Undervisning i muntlighet är ett omfattande fält som kan beröra t.ex. muntliga textlandskap, frågor om språkbruk och pragmatik, retorik, drama och teater. Den andra plenartalaren, Synnøve Matre från Trondheim, diskuterar  samtalens möjligheter i barns utveckling och lärande. Hon visar att yngre barn för såväl presenterande som lekande och utforskande samtal. Utforskande samtalstexter kommer till genom strategier som att ställa upp villkor, att opponera sig, att jämföra och att låna språkliga format av samtalspartnern. Samtal är mycket viktiga för barns språk- och kunskapsutveckling, och Matre ger handfasta exempel på hur man i undervisningen kan arbeta systematiskt med att utveckla barns samtalsfärdigheter.

    Bland de övriga bidragen finns Anders Öhmans diskussion om det dialogiska klassrummet och Kent Adelmanns resonemang om lyssnandet i didaktiska sammanhang. Två bidrag behandlar uttalat retoriska spörsmål, dels Anders Sigrells artikel om lärarens förebildlighet och elevers förmåga att efterbilda, dels Berit Lundgrens artikel om arbete med retorik i Sydafrika och Sverige. Bedömning av elevers muntliga kompetens är temat i tre av bidragen. Barbro Hagberg-Persson diskuterar hur elevers språkbehärskning kan mätas i de nationella proven för årskurs 3. I Anne Palmérs artikel studeras det muntliga nationella provet för Svenska B i gymnasiet efter förändringarna ht 2007 och samstämmigheten i lärares betygssättning. Maria Brännström redovisar en intervjuundersökning med svensklärare om det tidigare muntliga nationella provet i samma kurs.

    Litteraturundervisning dryftas i två artiklar. Maria Ulfgard diskuterar, utifrån tre nordiska avhandlingar, forskning om och undervisning i litteratur med särskilt fokus på litteratursamtal. Litteraturundervisning på läkarutbildningen är ämnet i Margareta Peterssons och Annette Årheims bidrag. I ytterligare ett par artiklar behandlas skrivundervisning. Per Holmberg presenterar forskning inom projektet Text- och kunskapsutveckling i skolan (TOKIS), i en artikel omtextsamtal i skrivundervisningen på gymnasiet. Elevers skrivande av  sändare och webbtexters eventuella betydelse för detta är ämnet i Catharina Nyström Höögs artikel. Det sista bidraget i volymen är Bengt-Göran Martinssons artikel om den ämnesdidaktiska diskussion som har förts inom  Svensklärarföreningen.

  • Van Haren, Merel M.
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi. Leiden Univ, Naturalis Biodivers Ctr, Vondellaan 55, NL-2332 AA Leiden, Netherlands..
    Rönn, Johanna
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Schilthuizen, Menno
    Leiden Univ, Naturalis Biodivers Ctr, Vondellaan 55, NL-2332 AA Leiden, Netherlands..
    Arnqvist, Göran
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Postmating sexual selection and the enigmatic jawed genitalia of Callosobruchus subinnotatus2017Inngår i: BIOLOGY OPEN, ISSN 2046-6390, Vol. 6, nr 7, 1008-1012 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Insect genitalia exhibit rapid divergent evolution. Truly extraordinary structures have evolved in some groups, presumably as a result of postmating sexual selection. To increase our understanding of this phenomenon, we studied the function of one such structure. The male genitalia of Callosobruchus subinnotatus (Coleoptera: Bruchinae) contain a pair of jaw-like structures with unknown function. Here, we used phenotypic engineering to ablate the teeth on these jaws. We then experimentally assessed the effects of ablation of the genital jaws on mating duration, ejaculate weight, male fertilization success and female fecundity, using a double-mating experimental design. We predicted that copulatory wounding in females should be positively related to male fertilization success; however, we found no significant correlation between genital tract scarring in females and male fertilization success. Male fertilization success was, however, positively related to the amount of ejaculate transferred by males and negatively related to female ejaculate dumping. Ablation of male genital jaws did not affect male relative fertilization success but resulted in a reduction in female egg production. Our results suggest that postmating sexual selection in males indeed favors these genital jaws, not primarily through an elevated relative success in sperm competition but by increasing female egg production.

  • Disputas: 2017-11-03 13:00 F3, Stockholm
    Karagulyan, Davit
    KTH, Skolan för teknikvetenskap (SCI), Matematik (Inst.).
    Certain results on the Möbius disjointness conjecture2017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    We study certain aspects of the Möbius randomness principle and more specifically the Möbius disjointness conjecture of P. Sarnak. In paper A we establish this conjecture for all orientation preserving circle homeomorphisms and continuous interval maps of zero entropy. In paper B we show, that for all subshifts of finite type with positive topological entropy the Möbius disjointness does not hold. In paper C we study a class of three-interval exchange maps arising from a paper of Bourgain and estimate its Hausdorff dimension. In paper D we consider the Chowla and Sarnak conjectures and the Riemann hypothesis for abstract sequences and study their relationship.

  • Lindgren, Maria
    et al.
    Institutionen för humaniora, Växjö universitet.
    Byrman, GunillaVäxjö universitet.Einarsson, JanSpråk- och litteraturcentrum, Lunds universitet.Hammarbäck, SolveigVäxjö universitet.Skoglund, Astrid
    Femte nationella konferensen i svenska med didaktisk inriktning: Forskningens tillämpning i skolan, Växjö den 29–30 november 20072008Collection/Antologi (Annet vitenskapelig)
    Abstract [sv]

    Tema för volymen är Forskningens tillämpning i skolan. I denna formulering ligger en önskan om att den didaktiska forskningen ska nå ut till skolorna. Två texter tyder på att så inte sker. Rolf Hedquists text handlar om den forskningsinformation som han får ta del av som jordbrukare och hästägare och lyfter fram den som ett gott exempel på forskningsförmedling. Han poängterar också att forskningsproblemen bör genereras i skolan och belysas i nära samarbete med skolans lärare. Hans text inspirerar till en bättre koppling mellan den didaktiska forskningen och skolpraktiken. Britta Herder presenterar en översikt om forskning om läs‐ och skrivundervisning som hon arbetat med åt Skolverket, och även den uppvisar en bild av att forskningen inte når ut till skolorna, men också att det är mycket som är outforskat vad gäller läs‐ och skrivundervisningen. De andra artiklarna visar att det finns en stark koppling mellan svenskdidaktisk forskning och skolpraktik, men problemet är att forskningsresultaten inte tycks nå ut till dem som närmast berörs av dem.

    Några bidrag innehåller beskrivningar av svenskdidaktiken. Sofia Ask visar att det är de enskilda gymnasielärarnas didaktiska ställningstaganden som avgör om eleverna förbereds för det akademiska skrivandet. Maria Lindgren har studerat individuella utvecklingsplaner (IUP) i tre årskurser i grundskolan och visar att skrivandet får stort utrymme i planerna i åk 2, att muntligheten får stort utrymme i åk 8 och att kommentarer om att läsa och skriva endast tas upp i åk 5 om språkfärdigheterna upplevs som problematiska. Stefan Lundström beskriver hur fiktionstexter väljs i gymnasiets svenskundervisning. Han pekar på att läroplaner kan vara svåra att tolka och därför leder till osäkerhet bland lärarna, vilket i sin tur leder till en reproduktiv undervisning. Maria Löfgren resonerar om varför skönlitteratur är viktig inom svenskämnet och beskriver hur läsningen gestaltas i två klassiska verk.

    Några andra bidrag handlar om hur undervisningen kan förbättras i överensstämmelse med de mål som finns i kursplanerna. Ewa Bergh Nestlog ger idéer till undervisning om argumenterande skrivande för 10–12‐åringar, Mary Ingemansson ger förslag på hur skönlitteratur kan användas för att ge ökad historiemedvetenhet hos 10–11‐åringar, och Christina Olin Scheller uppmanar lärarna att utnyttja de digitala mediernas ”medskapande kulturer” som informella lärandemiljöer. Anne Palmér beskriver sitt avhandlingsarbete om muntlig kommunikation i gymnasieskolan – hur hon bestämde sig för ämne och teoretisk anknytning och hur hon valde material och analysmetoder – när hon problematiserar begreppet ’språklig färdighet’ och argumenterar för att innehåll och form ska ses som en språklig enhet i undervisningen. Slutligen argumenterar Anders Sigrell för att lärarstudenter som ska undervisa i svenska själva bör ha tränat sitt skrivande, och han rekommenderar de antika progymnasmataövningarna, som också beskrivs i artikeln.

    En mer teoretisk ansats finns i Kristina Danielssons och Ulla Ekvalls artikel som sätter forskningsmetoden i centrum när de diskuterar sina planer på att analysera ett forskningsmaterial hämtat från ämnet kemi i svenska och finska klassrum.

  • Li, Chun-Mei
    et al.
    Shenyang Normal Univ, Coll Phys Sci & Technol, Shenyang 110034, Peoples R China.;Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, 72 Wenhua Rd, Shenyang 110016, Peoples R China..
    Johansson, Börje
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori. KTH Royal Inst Technol, Dept Mat Sci & Engn, S-10044 Stockholm, Sweden.; Dalian Univ Technol, Sch Phys & Optoelect Technol, Dalian 116024, Peoples R China.;Dalian Univ Technol, Coll Adv Sci & Technol, Dalian 116024, Peoples R China..
    Vitos, Levente
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori. KTH Royal Inst Technol, Dept Mat Sci & Engn, S-10044 Stockholm, Sweden.;Wigner Res Ctr Phys, Res Inst Solid State Phys & Opt, POB 49, HU-1525 Budapest, Hungary..
    Physical mechanism of delta-delta '-epsilon phase stability in plutonium2017Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 5632Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Based on first-principle calculations, we have systematically explored the nature of the elastic stability and the delta-delta'-epsilon phase transitions in pure Pu at high temperature. It is found that, both the electronphonon coupling and the spin fluctuation effects tend to decrease the tetragonal elastic constant (C') of delta-Pu, accounting for its anomalous softening at high temperature. The lattice thermal expansion together with the electron-phonon coupling can stiffen C' of epsilon-Pu, promoting its mechanical stability at high temperature. The delta-epsilon transition is calculated to take place around 750-800 K, and is dominated by the phonon vibration. The delta' intermediate phase is realized around 750 K mainly because of the thermal spin fluctuation.

  • Sigrell, Anders
    et al.
    Språk och litteraturcentrum, Lunds universitet.
    Einarsson, JanSpråk- och litteraturcentrum, Lunds universitet.Hedqvist, RolfFakulteten för lärarutbildning, Umeå universitet.Kåreland, LenaUppsala universitet.Lundgren, BeritInstitutionen för språkstudier, Umeå universitet.Munck, Kerstin
    Fjärde nationella konferensen i svenska med didaktisk inriktning: Tala, lyssna, skriva, läsa, lära – modersmåls-ndervisning i ett nordiskt perspektiv, Umeå 16–17 november 20062007Collection/Antologi (Annet vitenskapelig)
    Abstract [sv]

    Temat för konferensen i Umeå var ”Tala, lyssna, skriva, läsa, lära –  modersmålsundervisning i ett nordiskt perspektiv”. De inledande fem honnörsorden i rubriken var inte tänkta som ett eko ur det förflutna, det vill säga från momentsplittringen i de gamla Lgr 69 och Lgy 70, utan fick ge namn åt parallella sessioner där svenskämnets helhet var en självklar utgångspunkt. Forskning om elevers språkutveckling i vid mening stimuleras av en vidare didaktisk syn som inte begränsas till enbart modersmålsundervisning. Forskning om hur man talar, lyssnar, läser och skriver i inlärningssituationer är något vi vill tro kan komma all undervisning till del.

    Det finns en risk med att sätta ’språkutveckling’ i fokus, som om studier inom fältet Svenska med didaktisk inriktning vore renodlat språkinriktade. Så är det inte. Forskning om hur skönlitteratur, och andra kommunikationsformer, kommer in i klassrummet är ett centralt forskningsområde som Nätverket vill stödja, vilket läsaren av denna konferensvolym kommer att upptäcka. Rapporter från projektet ”Den skönlitterära texten i skola och lärarutbildning” liksom samtal om framtida möjliga projekt var uppskattade inslag i konferensen. Svenska är det största ämnet i skolan, med vilka mått man än mäter och vilka aspekter man än betonar. I skolämnet Svenska ingår språk- och litteraturstudier. En lektor och lärarutbildare har än så länge normalt bara fördjupad kompetens i en av ämnets delar. Framväxten av forskarutbildning inom Svenska med didaktisk inriktning innebär på sikt en dubblering av kompetensen. Glädjande nog deltog flera doktorander och disputerade inom fältet Svenska med didaktisk inriktning i konferensen, vilket också avspeglas i denna volym.

    Ett utvecklat samarbete mellan universitetsämnena nordiska språk och litteraturvetenskap samt med Lärarutbildningen är en självklar förutsättning för utbildning av kvalificerade svensklärare. Vid Umeå universitet studeras nordiska språk och litteraturvetenskap vid en och samma institution, en lösning som bidragit till ett fördjupat samarbete i lärarutbildningen. Representanter från lärarutbildning, litteraturvetenskap och nordiska språk ingår också i ledningsgruppen för Nätverket, vilket bidragit till att arbetet med konferensen och konferensvolymen varit stimulerande och verklighetsförankrat.

    Svenskämnets storlek och betydelse gör att behovet av forskning inom både ungdomsskola, lärarutbildningar och andra inlärningssituationer är mycket stort. Nätverkets konferenser ska stimulera till adekvat forskning inom området och vara en naturlig mötesplats för forskare att presentera sina rön. Med konferensvolymen från Smdi:s fjärde konferens tar vi ännu ett steg framåt. Plenarföredragen får inleda volymen, varefter sektionsföredragen kommer i bokstavsordning.

  • Disputas: 2017-10-31 10:15 1B 309, Sjöströmsalen, Karlstad
    Larsson, Ida
    Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), Institutionen för ingenjörs- och kemivetenskaper. RISE Research Institutes of Sweden.
    Measurement of Self-Heating of Biomass Pellets using Isothermal Calorimetry2017Licentiatavhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Self-heating in storage facilities of biomass pellet can lead to spontaneous combustion. This has resulted in many fires over the years, causing both financial and environmental losses.

    In order to assess the risk for spontaneous combustion of biomass pellets during storage, it is important to know how prone the fuel is to self-heating, i.e. to determine its reactivity. This thesis presents experimental work performed to develop a sensitive screening test procedure for biomass pellets, using isothermal calorimetry for direct measurement of the heat production rate. This method can be used to compare the reactivity of different biomass pellets. This could be useful for e.g. facility owners to gain better knowledge of their fuels propensity for self-heating and thereby facilitate safer storage.

    The screening test procedure can also be used for research purposes. Experiments have been performed with 31 different biomass pellet batches to investigate how the pellet composition, origin, etc. influence the reactivity of the pellets. The results from these experiments clearly show a significant difference in reactivity between different types of pellets. The results indicate that pine/spruce mix pellets are significantly more reactive than all other types of pellets tested, and that pellets consisting of 100 % pine are more reactive than pellets consisting of 100 % spruce. Pellets produced from winery wastes, straw, or eucalyptus, have low reactivity compared to pellets consisting of pine and/or spruce. The reactivity of the pellets was shown to be reduced by either introducing certain types of anti-oxidants into the pellets or by extracting lipids from the raw material of pellets.

    The screening test procedure is already being used today by some facility owners for assessing their fuels propensity for self-heating. The procedure is also one of the suggested test methods in “ISO/CD 20049 Solid biofuels — Determination of self-heating of pelletized biofuels”.