1234567 1 - 50 of 531
rss atomLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
  • Public defence: 2017-09-15 10:00 E1405 (Gjuterisalen), Jönköping
    Bjurenstedt, Anton
    Jönköping University, School of Engineering, JTH. Research area Materials and manufacturing – Casting. Jönköping University, School of Engineering, JTH, Materials and Manufacturing.
    On the influence of imperfections on microstructure and properties of recycled Al-Si casting alloys2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    There are great energy savings to be made by recycling aluminium; as little as 5% of the energy needed for primary aluminium production may be required. Striving to produce high quality aluminium castings requires knowledge of microstructural imperfections, which is extra important when casting recycled aluminium that generally contains higher levels of imperfections compared to primary aluminium. Imperfections include amongst others Si, Fe, and Mn as well as oxides. Si is needed for castability, but it may also initiate fracture. There are different types of Fe-rich intermetallics influencing properties of castings, generally in a negative direction. Oxides constitute cracks and they are elusive because they are difficult to quantify.

    This thesis aims to increase knowledge about imperfections in recycled aluminium castings originating from alloying elements and the melt. Experiments were performed in advanced laboratory equipment, including X-radiographic imaging during solidification and in-situ tensile testing in a scanning electron microscope. Experiments were also performed at industrial foundry facilities.

    The experiments showed that the nucleation temperature of primary α-Fe intermetallics increased with higher Fe, Mn, and Cr contents. Primary α-Fe are strongly suggested to nucleate on oxides and to grow in four basic morphologies. Lower nucleation frequency of α-Fe promoted faster growth and hopper crystals while higher nucleation frequency promoted slower growth rates and massive crystals. Results also showed that a decrease in the size of the eutectic Si and plate-like β-Fe intermetallics improved tensile properties, foremost the elongation to fracture. In β-Fe containing alloys the transversely oriented intermetallics initiated macrocracks that are potential fracture initiation sites. In alloys with primary α-Fe foremost clusters of intermetallics promoted macrocracks. In fatigue testing, a transition from β-Fe to α-Fe shifted the initiation sites from oxides and pores to the α-Fe, resulting in a decrease of fatigue strength. Oxides in Al-Si alloys continue to be elusive; no correlations between efforts to quantify the oxides and tensile properties could be observed.

  • Eklund, Britt
    Institute for Language and Folklore.
    Dräktalmanacka: Boda socken, Dalarna2016Book (Other academic)
  • Public defence: 2017-09-08 10:00 Föreläsningssal 5
    Borg, Farhana
    Dalarna University, School of Education, Health and Social Studies, Educational Work. Umeå universitet, Institutionen för tillämpad utbildningsvetenskap.
    Caring for people and the planet: preschool children’s knowledge and practices of sustainability2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Children across the globe today are continuously being exposed to and affected by various kinds of real-world complexities and challenges; however, research on their knowledge and practices in terms of sustainability is limited, in particular with regards to how preschool- and home-related factors are associated with their learning for sustainability. Since 1998, different types of eco-certification have been awarded by the Swedish National Agency for Education and Keep Sweden Tidy Foundation to promote education for sustainability (EfS) in all areas of education and learning. Despite certificates having been granted in Sweden since 1998, no studies have been conducted at the national level to investigate whether eco-certification has any role to play in children’s learning for environmental and sustainability issues. This knowledge is important to develop pedagogical activities to engage young children meaningfully in learning for sustainability at preschool. This study was undertaken so as to address this research gap in a Swedish context.

    The overall aim of this study was to enhance the existing knowledge about preschool children’s learning for sustainability in Sweden. The objectives of this study have been to investigate and compare the knowledge and self-reported practices of sustainability among children attending eco-certified and non-eco-certified preschools, respectively, and to explore the extent to which preschool- and home-related factors are associated with children’s knowledge and practices of sustainability. Further, this study explored children’s perceived sources of such knowledge. The term ‘knowledge’ in this text refers to the descriptions of children’s ideas and thoughts. Similarly, eco-certified preschool refers to a school that work explicitly with EfS.

    The study was designed from a "child’s perspective": this means that it was designed by adults to understand children’s perceptions and actions. Bandura’s (1977) social learning theory and Bruner’s (1961) iconic (image-based) modes of representation were applied in various stages of the study. A conceptual framework was developed within the three-interlocking-circles model of sustainability that illustrates how environmental, social and economic dimensions are interconnected. The concept of sustainability was operationalized in four themes: economic equality, resource sharing, recycling and transport use.

    With the use of illustrations and semi-structured questions, final-year preschool children (n=53), aged five to six years, and the directors (n=7) at six eco-certified and six non-eco-certified preschools were interviewed, while guardians (n=89) and teachers (n=74) filled out questionnaires. Qualitative and quantitative data were analyzed using content analysis and Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA), respectively. The quality and complexity of children’s responses were assessed and classified using the SOLO Taxonomy (Biggs & Collis, 1982).

    The results showed that by the time the children completed preschool, many had acquired some knowledge about how to use money, about the sorting of different recyclable items at home and at preschool, and about the impact of different modes of transport on the environment and people’s lives. They also had ideas about the lives of other children in the world and what it can mean to share resources with other people. There was a positive relationship between children’s declarative (understanding) and functional (practice) knowledge of sustainability issues and the involvement of teachers and guardians in sustainability-related discussions and activities. No statistically significant differences between eco-certified and non-eco-certified preschools in terms of children’s declarative and functional knowledge were found. Parents were reported to be the main sources of children’s knowledge along with the children themselves, teachers and media.

    The findings offer support for integrating environmental, social and economic dimensions of sustainability into the daily pedagogical activities of preschools and for giving children opportunities to participate in discussions and practical activities that concern their lives. Further studies are needed to investigate the extent to which different educational activities contribute to developing children’s understanding and behavior when it comes to a sustainable society.

  • Nigrisoli Wärnhjelm, Vera
    Dalarna University, School of Humanities and Media Studies, Italian.
    Medical Minutes of the 17th Century2017In: Queen Christina of Sweden, the European: Contribution to Seminars 2014-2015 / [ed] Mats Liljefors, Kersti Schold Linnér, Stockholm: Royal Festivals AB , 2017, 89-96 p.Chapter in book (Refereed)
  • Saati, Abrak
    Umeå University, Faculty of Social Sciences, Department of Political Science.
    Participatory Constitution-Building in Nepal: A Comparison of the 2008-2012 and the 2013-2015 Process2017In: Journal of Politics and Law, ISSN 1913-9047, E-ISSN 1913-9055, Vol. 10, no 4, 29-39 p.Article in journal (Refereed)
    Abstract [en]

    Participatory constitution-building is a trend that appears to be here to stay; particularly when new constitutions are drafted in the aftermath of war or during transitions from authoritarian to democratic rule. Anticipations as to what the involvement of the public will achieve are several, and scholars are only recently starting to systematically investigate whether or not these expectations find empirical support. Previous research has shown that public participation in the making of the constitution can have certain positive effects at an individual level of analysis, but that the actions of political elites during constitutional negotiations might affect outcomes at a macro level of analysis more than what has hitherto be acknowledged in this strand of research. Nepal is one of the most recent cases of participatory constitution-building, and the country carried out not only one, but two, such processes within a time period of only seven years. The first resulted in failure as a draft constitution was never finalized; the other in success with the adoption of a constitution in 2015. This article takes an interest in exploring and comparing these two separate processes as regards the extent of public participation vis-à-vis political elite negotiations and bargaining behind closed doors. The article finds that what primarily sets the two processes apart, is how broad based public participation and secluded elite negotiations were sequenced. In light of other empirical examples, the article also discusses if elite bargains ought to be struck before the general public are invited to participate.

  • Public defence: 2017-09-13 09:00 B7 111:a, BMC, Uppsala
    Zhao, Jin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Sequence based identification of genetic variation associated with intellectual disability2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Intellectual disability (ID) is a common neurodevelopmental condition, often caused by genetic defects. De novo variation (DNV) is an important cause of ID, especially in severe or syndromic forms of the disorder. Next generation sequencing has been a successful application for finding pathogenic variation in ID patients. The main focus of this thesis is to use whole exome sequencing (WES) and whole genome sequencing (WGS) to identify pathogenic variants in undiagnosed ID patients. In Paper I, WES was used in family trios to identify pathogenic DNVs in patients diagnosed with ID in combination with epilepsy. This work led to the identification of several DNVs in both new and known disease genes, including the first report of variation in the HECW2 gene in association with neurodevelopmental disorder and epilepsy. Paper II is the first independent validation of PIGG as a disease-causing gene in patients with developmental disorder. We used WES to identify the homozygous variation in PIGG, and transcriptome analysis as well as flow-cytometry studies were used to validate the pathogenicity of the PIGG variation. We discovered that PIGG variation give different effects in different cell types, contributing new insights into the disease mechanism. Paper III is also an application of WES in trio families with patients diagnosed with ID in order to identify causal variants, a strategy similar to that of Paper I. Several pathogenic variants were identified in this study; in particular, the gene NAA15 is highlighted as a new disease gene, and was recently confirmed in independent studies. This study also adds evidence to support that variation in the PUF60 gene is causing the symptoms in patients with Verheij syndrome. In Paper IV, WGS was used to analyze families with consanguineous marriages. All families in this study had been previously analyzed with WES without finding a disease cause. A number of new disease-causing variants were identified in the study, including a first validation of FRMD4A as a disease-associated gene. This study also shows that WGS performs better than WES in finding variants, even for variants in coding parts of the genome.

  • Public defence: 2017-10-20 16:04
    Ahlin, Jesper
    Philosophy and History, KTH, School of Architecture and the Built Environment (ABE), Philosophy and History of Technology, Philosophy.
    Personal Autonomy and Informed Consent: Conceptual and Normative Analyses2017Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    This licentiate thesis is comprised of a “kappa” and two articles. The kappa includes an account of personal autonomy and informed consent, an explanation of how the concepts and articles relate to each other, and a summary in Swedish.

    Article 1 treats one problem with the argument that a patient’s consent to treatment is valid only if it is authentic, i.e., if it is “genuine,” “truly her own,” “not out of character,” or similar. As interventions with a patient’s life and liberties must be justified, the argument presupposes that the authenticity of desires can be reliably determined. If the status of a desire in terms of authenticity cannot be reliably determined, discarding the desire-holder’s treatment decision on the basis that it is inauthentic is morally unjustified. In the article, I argue that no theory of authenticity that is present in the relevant literature can render reliably observable consequences. Therefore, the concept of authenticity, as it is understood in those theories, should not be part of informed consent practices.

    Article 2 discusses the problem of what it is to consent or refuse voluntarily. In it, I argue that voluntariness should be more narrowly understood than what is common. My main point is that a conceptualization of voluntariness should be agent-centered, i.e., take into account the agent’s view of her actions. Among other things, I argue that an action is non-voluntary only if the agent thinks of it as such when being coerced. This notion, which at first look may seem uncontroversial, entails the counterintuitive conclusion that an action can be voluntary although the agent has been manipulated or coerced into doing it. In defense of the notion, I argue that if the agent’s point of view is not considered accordingly, describing her actions as non-voluntary can be alien to how she leads her life. There are other moral concepts available to describe what is wrong with manipulation and coercion, i.e., to make sense of the counterintuitive conclusion. Voluntariness should be reserved to fewer cases than what is commonly assumed.

  • Public defence: 2017-09-04 11:38 E10:2309, Uppsala
    Steinhauf, Daniel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Importance of the Clr2 protein in heterochromatin formation in the fission yeast Schizosaccharomyces pombe.2017Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    Epigenetics is an area of biology that studies heritable changes in gene ex- pression without any change in the DNA sequence. The most studied epige- netic mechanisms are DNA methylation, RNA interference and histone mod- ifications. There are over 130 different modifications that can be attached to histones, and the most commonly studied are methylation, acetylation, phos- phorylation, sumoylation and ubiquitination. The modifications, spread out through the genome, form the histone code, which recruits transcription fac- tors and modifies the accessibility of the DNA, which results in either active or silenced transcription. The silenced form of chromatin is known as heter- ochromatin and is usually found in regions of the chromosome that need to be highly regulated. To study epigenetics, the model organism Schizosac- charomyces pombe is used widely used. S. pombe is a single cell, rod shaped, fission yeast. The simplicity of S. pombe and its similarities to high- er eukaryotes makes it a good model organism for studying epigenetics. We find that, when mutating evolutionary conserved amino acids in the Clr2 protein, which is involved in heterochromatin formation in S. pombe, there is a change in silencing in different heterochromatic regions. When constructs of Clr2 with the BAH domain deleted are overexpressed, there is an increase in silencing in the central core centromere of chromosome II of S. pombe. 

  • Norström, Fredrik
    et al.
    Umeå Univ, Dept Publ Hlth & Clin Med Epidemiol & Global Hlth, SE-90187 Umeå, Sweden..
    Janlert, Urban
    Umeå Univ, Dept Publ Hlth & Clin Med Epidemiol & Global Hlth, SE-90187 Umeå, Sweden..
    Hammarström, Anne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Is unemployment in young adulthood related to self-rated health later in life?: Results from the Northern Swedish cohort2017In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 17, 529Article in journal (Refereed)
    Abstract [en]

    Background: Many studies have reported that unemployment has a negative effect on health. However, little is known about the long-term effect for those who become unemployed when they are young adults. Our aim was to examine how unemployment is related to long-term self-rated health among 30 year olds, with an emphasis on how health differs in relation to education level, marital status, previous health, occupation, and gender. Methods: In the Northern Swedish Cohort, 1083 teenagers (similar to 16 years old) were originally invited in 1981. Of these, 1001 participated in the follow-up surveys in 1995 and 2007. In our study, we included participants with either self-reported unemployment or activity in the labor force during the previous three years in the 1995 follow-up so long as they had no self-reported unemployment between the follow-up surveys. Labor market status was studied in relation to self-reported health in the 2007 follow-up. Information from the 1995 follow-up for education level, marital status, self-reported health, and occupation were part of the statistical analyses. Analyses were stratified for these variables and for gender. Analyses were performed with logistic regression, G-computation, and a method based on propensity scores. Results: Poor self-rated health in 2007 was reported among 43 of the 98 (44%) unemployed and 159 (30%) of the 522 employed subjects. Unemployment had a long-term negative effect on health (odds ratio with logistic regression 1.74 and absolute difference estimates of 0.11 (G-computation) and 0.10 (propensity score method)). At the group level, the most pronounced effects on health were seen in those with upper secondary school as their highest education level, those who were single, low-level white-collar workers, and women. Conclusions: Even among those becoming unemployed during young adulthood, unemployment is related to a negative long-term health effect. However, the effect varies among different groups of individuals. Increased emphasis on understanding the groups for whom unemployment is most strongly related to ill health is important for future research so that efforts can be put towards those with the biggest need. Still, our results can be used as the basis for deciding which groups should be prioritized for labor-market interventions.

  • Riede, Felix
    et al.
    Aarhus Univ.
    Andersen, Per
    Aarhus Univ.
    Price, Neil
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    Does environmental archaeology need an ethical promise?2017In: World archaeology, ISSN 0043-8243, E-ISSN 1470-1375, Vol. 48, no 4, 466-481 p.Article in journal (Refereed)
    Abstract [en]

    Environmental catastrophes represent profound challenges faced by societies today. Numerous scholars in the climate sciences and the humanities have argued for a greater ethical engagement with these pressing issues. At the same time, several disciplines concerned with hazards are moving towards formalized ethical codes or promises that not only guide the dissemination of data but oblige scientists to relate to fundamentally political issues. This article couples a survey of the recent environmental ethics literature with two case studies of how past natural hazards have affected vulnerable societies in Europe's prehistory. We ask whether cases of past calamities and their societal effects should play a greater role in public debates and whether archaeologists working with past environmental hazards should be more outspoken in their ethical considerations. We offer no firm answers, but suggest that archaeologists engage with debates in human-environment relations at this interface between politics, public affairs and science.

  • Nyberg, Elisabeth
    et al.
    Executive, Naturhistoriska riksmuseet, NRM.
    Aune, Marie
    Executive, Myndigheter, Livsmedelsverket, SLV.
    Awad, Raed
    Executive, Universitet, Stockholms universitet, SU, Stockholms universitet, institutionen för tillämpad miljövetenskap, ITM.
    Benskin, Jon
    Executive, Universitet, Stockholms universitet, SU, Stockholms universitet, institutionen för tillämpad miljövetenskap, ITM.
    Bergh, Arpi
    Executive, Myndigheter, Livsmedelsverket, SLV.
    Bignert, Anders
    Executive, Naturhistoriska riksmuseet, NRM.
    Dahlgren, Henrik
    Executive, Naturhistoriska riksmuseet, NRM.
    Danielsson, Sara
    Executive, Naturhistoriska riksmuseet, NRM.
    de Wit, Cynthia
    Executive, Universitet, Stockholms universitet, SU.
    Egebäck, Anna-Lena
    Executive, Universitet, Stockholms universitet, SU, Stockholms universitet, institutionen för tillämpad miljövetenskap, ITM.
    Ek, Caroline
    Executive, Naturhistoriska riksmuseet, NRM.
    Eriksson, Ulla
    Executive, Universitet, Stockholms universitet, SU, Stockholms universitet, institutionen för tillämpad miljövetenskap, ITM.
    Kruså, Martin
    Executive, Universitet, Stockholms universitet, SU, Stockholms universitet, institutionen för tillämpad miljövetenskap, ITM.
    Näslund, Matilda
    Executive, Myndigheter, Livsmedelsverket, SLV.
    Sallsten, Gerd
    Executive, Universitet, Göteborgs universitet, Göteborgs universitet, arbets- och miljömedicin.
    Monitoring of POPs in human milk from Stockholm and Gothenburg, 1972-20152017Report (Other academic)
    Abstract [en]

    The environmental contaminants examined in this report can be classified into five groups –organochlorine pesticides (DDTs, HCHs and HCB), polychlorinated biphenyls (PCBs), brominated flame retardants (PBDEs and HBCDD), dioxins, furans and dioxin-like PCBs (PCDD/PCDFs and dl-PCBs) and perfluorinated compounds (PFASs). Each of these contaminants has been examined in human milk from Stockholm and Gothenburg. The following summary examines overall trends, both spatial and temporal, for the five groups and also individual differences in PFASs concentration between Stockholm and Gothenburg.

    Fat Content

    Human milk from Stockholm displayed an upward trend in fat content during the whole monitoring period, although a downward trend was observed during the most recent ten years. However, a change in analythical method in 2011 might have had an impact on the trend during the most recent ten years. Increasing fat content was indicated in human milk from Gothenburg (2007-2015). The fat content estimated from the smoothed line was slightly higher in the milk from Gothenburg than in the milk from Stockholm.

    PCBs

    Generally, a downward trend was observed for all congeners measured i.e. CB-180, CB-153, CB-138 and CB-118 in human milk from both Stockholm and Gothenburg, with the exception of CB-28 for which no trend was detected. The concentrations of the measured congeners were comparable between Stockholm and Gothenburg and there was no significant difference in PCB congener pattern between the two cities.

    DDTs, HCHs and HCB

    The concentrations of DDE, DDT and HCB in human milk from Stockholm decreased significantly during the whole monitoring period and so did DDE and DDT in the milk from Gothenburg during the most recent ten years. The concentrations of DDE/DDT and β-HCH estimated from the smoothed line were slightly higher in Stockholm than in Gothenburg whereas HCB was slightly higher in Gothenburg. There was no significant difference in the DDE, DDT, HCB and β-HCH pattern between Stockholm and Gothenburg.

    PCDD/PCDFs and dl-PCBs

    The concentrations of ΣPCDDs, ΣPCDFs, Σdl-PCBs and ΣPCDDs+PCDFs+dl-PCBs in human milk from Stockholm and Gothenburg decreased significantly during the whole monitoring period. However during the most recent ten years no trends were observed for the Stockholm milk. The concentrations were comparable between Stockholm and Gothenburg and there was no significant difference in the pattern for ΣPCDDs, ΣPCDFs, Σdl-PCBs between Stockholm and Gothenburg.

    PBDEs and HBCDD

    The concentrations of BDE-47, BDE-99 and BDE-100 in human milk from Gothenburg decreased significantly during 2007-2015 whereas no trends were observed in the milk from Stockholm. The concentrations estimated from the smoothed line were higher in Stockholm than in Gothenburg for all BFRs reported here (i.e. BDE-28, BDE-47, BDE-99, BDE-100, BDE-153 and HBCDD). There was no significant difference in the pattern for BDE-47, BDE-99, BDE-100, BDE-153 and HBCDD between Stockholm and Gothenburg. 11

    PFASs

    The concentrations of PFDA, PFHxS, PFNA, PFTriDA and PFUDA in human milk from Stockholm increased significantly during the whole monitoring period, whereas PFOA concentrations were decreasing. In the human milk samples from Gothenburg significant downward trends were detected for PFDoDA, PFHxS and PFOA and that was also the case for PFOS in Stockholm for the most recent ten years. The concentrations estimated from the smoothed line were in general higher in Stockholm than in Gothenburg, with the exception of FOSA, PFTeDA and PFTriDA. There was no significant difference in the pattern for PFOA, PFOS, PFNA, PFDA, PFUDA and PFTriDA between Stockholm and Gothenburg.

  • Ruan, Changqing
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Strømme, Maria
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Mihranyan, Albert
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Lindh, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Favored Surface-limited Oxidation of Cellulose with Oxone® in Water2017In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 7, 40600-40607 p.Article in journal (Refereed)
    Abstract [en]

    A novel method for favored primary alcohol oxidation of cellulose was developed. Cellulose pulp andCladophora nanocellulose were oxidized in a one-pot procedure by Oxone® (2KHSO5$KHSO4$K2SO4)and efficient reaction conditions were identified. The effects of the reaction on the morphology,viscosity and chemical structure of the products obtained were studied. The primary alcohol groupswere oxidized to carboxyl groups and the content of carboxyl groups was determined byconductometric titration. SEM, capillary-type viscometry and XRD were applied to characterize theproducts and to investigate the influence of oxidation. For the first time, low-cost and stable Oxone®was used as a single oxidant to oxidize cellulose into carboxyl cellulose. The oxidation is an inexpensiveand convenient process to produce carboxylic groups on the surface of the cellulose fibers and to makethe cellulose fibers charged. Particularly, this method can avoid the use of halogens and potentially toxicradicals and constitute a green route to access carboxylated cellulose. Further, sodium bromide could beused as a co-oxidant to the Oxone® and increase the carboxylic acid content by 10–20%. The Oxone®oxidation is a promising method for oxidation of cellulose and might facilitate the production of CNC.

  • Elmberg, Johan
    et al.
    Kristianstad University, School of Education and Environment, Avdelningen för Naturvetenskap. Kristianstad University, Research environment Man & Biosphere Health (MABH).
    Berg, Charlotte
    Swedish University of Agricultural Sciences.
    Lerner, Henrik
    Ersta Sköndal Bräcke University College.
    Waldenström, Jonas
    Linneaus University.
    Hessel, Rebecca
    Kristianstad University, School of Education and Environment, Avdelningen för Naturvetenskap. Kristianstad University, Research environment Man & Biosphere Health (MABH).
    Potential disease transmission from wild geese and swans to livestock, poultry and humans: a review of the scientific literature from a One Health perspective2017In: Infection Ecology & Epidemiology, ISSN 2000-8686, E-ISSN 2000-8686, Vol. 7, no 1Article in journal (Refereed)
    Abstract [en]

    There are more herbivorous waterfowl (swans and geese) close to humans, livestock and poultry than ever before. This creates widespread conflict with agriculture and other human interests, but also debate about the role of swans and geese as potential vectors of disease of relevance for human and animal health. Using a One Health perspective, we provide the first comprehensive review of the scientific literature about the most relevant viral, bacterial, and unicellular pathogens occurring in wild geese and swans. Research thus far suggests that these birds may play a role in transmission of avian influenza virus, Salmonella, Campylobacter, and antibiotic resistance. On the other hand, at present there is no evidence that geese and swans play a role in transmission of Newcastle disease, duck plague, West Nile virus, Vibrio, Yersinia, Clostridium, Chlamydophila, and Borrelia. Finally, based on present knowledge it is not possible to say if geese and swans play a role in transmission of Escherichia coli, Pasteurella, Helicobacter, Brachyspira, Cryptosporidium, Giardia, and Microsporidia. This is largely due to changes in classification and taxonomy, rapid development of identification methods and lack of knowledge about host specificity. Previous research tends to overrate the role of geese and swans as disease vectors; we do not find any evidence that they are significant transmitters to humans or livestock of any of the pathogens considered in this review. Nevertheless, it is wise to keep poultry and livestock separated from small volume waters used by many wild waterfowl, but there is no need to discourage livestock grazing in nature reserves or pastures where geese and swans are present. Under some circumstances it is warranted to discourage swans and geese from using wastewater ponds, drinking water reservoirs, and public beaches. Intensified screening of swans and geese for AIV, West Nile virus and anatid herpesvirus is warranted.

  • Odelstad, Jan
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Industrial Development, IT and Land Management, Decision, Risk and Policy Analysis.
    Likvärdigt arbete och teorin om mellanbegrepp2017Report (Other academic)
  • Svidró, Judit
    et al.
    Jönköping University, School of Engineering, JTH, Materials and Manufacturing.
    Diószegi, Attila
    Jönköping University, School of Engineering, JTH, Materials and Manufacturing. Jönköping University, School of Engineering, JTH. Research area Materials and manufacturing – Casting.
    Tóth, L.
    University Of Miskolc, Department of Foundry Technology, Miskolc, Hungary.
    Svidró, József Tamás
    Jönköping University, School of Engineering, JTH, Materials and Manufacturing. Jönköping University, School of Engineering, JTH. Research area Materials and manufacturing – Casting.
    The influence of thermal expansion of unbonded foundry sands on the deformation of resin bonded cores2017In: Archives of Metallurgy and Materials, ISSN 1733-3490, E-ISSN 2300-1909, Vol. 62, no 2, 795-798 p.Article in journal (Refereed)
    Abstract [en]

    Depending on the preparation and the applied materials, moulds and cores can be of high rigidity or can be flexible. Although, chemically bonded moulding materials have relatively good flexibility, their high temperature behaviour determines the dimensional accuracy, the stresses in the castings and can induce several casting defects, such as rattail, veining, etc. The phenomenon is based on two major effects: the thermal expansion of the unbonded foundry sands and the deformation of the sand mixtures. The main objective of the present work was to study the relationship between these two effects, and to improve the knowledge related to the thermo-mechanical interactions between the casting and the mould. Dilatometric analysis of unbonded sand samples were performed and compared to the results of hot distortion tests of moulding mixture specimens. The results showed, that the thermal expansion of foundry sand largely influences the hot distortion behaviour, but depending on the type of binder used.

  • Public defence: 2017-09-13 09:00 A1:111 BMC, Uppsala
    Bauer, Paul
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Biochemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Computational modelling of enzyme selectivity2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Enantioselective reactions are one of the ways to produce pure chiral compounds. Understanding the basis of this selectivity makes it possible to guide enzyme design towards more efficient catalysts. One approach to study enzymes involved in chiral chemistry is through the use of computational models that are able to simulate the chemical reaction taking place. The potato epoxide hydrolase is one enzyme that is known to be both highly enantioselective, while still being robust upon mutation of residues to change substrate scope. The enzyme was used to investigate the epoxide hydrolysis mechanism for a number of different substrates, using the EVB approach to the reaction both in solution and in several enzyme variants. In addition to this, work has been performed on new ways of performing simulations of divalent transition metals, as well as development of new simulation software.

  • Public defence: 2017-10-10 10:30 N320, Naturvetarhuset, Umeå
    Khan, Muhammad Sikandar Lal
    Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics.
    Presence through actions: theories, concepts, and implementations2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    During face-to-face meetings, humans use multimodal information, including verbal information, visual information, body language, facial expressions, and other non-verbal gestures. In contrast, during computer-mediated-communication (CMC), humans rely either on mono-modal information such as text-only, voice-only, or video-only or on bi-modal information by using audiovisual modalities such as video teleconferencing. Psychologically, the difference between the two lies in the level of the subjective experience of presence, where people perceive a reduced feeling of presence in the case of CMC. Despite the current advancements in CMC, it is still far from face-to-face communication, especially in terms of the experience of presence.

    This thesis aims to introduce new concepts, theories, and technologies for presence design where the core is actions for creating presence. Thus, the contribution of the thesis can be divided into a technical contribution and a knowledge contribution. Technically, this thesis details novel technologies for improving presence experience during mediated communication (video teleconferencing). The proposed technologies include action robots (including a telepresence mechatronic robot (TEBoT) and a face robot), embodied control techniques (head orientation modeling and virtual reality headset based collaboration), and face reconstruction/retrieval algorithms. The introduced technologies enable action possibilities and embodied interactions that improve the presence experience between the distantly located participants. The novel setups were put into real experimental scenarios, and the well-known social, spatial, and gaze related problems were analyzed.

    The developed technologies and the results of the experiments led to the knowledge contribution of this thesis. In terms of knowledge contribution, this thesis presents a more general theoretical conceptual framework for mediated communication technologies. This conceptual framework can guide telepresence researchers toward the development of appropriate technologies for mediated communication applications. Furthermore, this thesis also presents a novel strong concept – presence through actions - that brings in philosophical understandings for developing presence- related technologies. The strong concept - presence through actions is an intermediate-level knowledge that proposes a new way of creating and developing future 'presence artifacts'. Presence- through actions is an action-oriented phenomenological approach to presence that differs from traditional immersive presence approaches that are based (implicitly) on rationalist, internalist views.

  • Morén, Göran
    Dalarna University, School of Education, Health and Social Studies, Educational Work. Karlstads universitet, Institutionen för pedagogiska studier.
    Samhällsfrågor som didaktiskt begrepp i samhällskunskap på gymnasieskolan: En potential för undervisningen2017Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    This licentiate thesis examines and discusses the potential of the subject social studies by way of an analysis of the concept social issues. It comprises three articles which are based on three separate studies. The first was a discourse analysis on the concept of social issues in steering documents for social studies in upper secondary school from the 1960’s until the current curriculum. The second was a questionnaire in which 74 social studies teachers answered questions regarding their understanding and teaching of social studies, specifically in relation to the concept of social issues. The third study was based on interviews with seven teachers who had completed the questionnaire.

    The study allows for a shift in focus between structure and agency. Whereas the structure dominates the analysis in the first article the teachers, with agency, gradually move into the foreground in the other articles. With a social-constructionist perspective, phenomena like a school subject and teaching practice are seen as formed by both structure, such as discourse, and agents, in this case professional teachers.

    The text analysis shows that social issues as a didactical concept is shifting in its meaning and didactical function for the subject depending on the discourse. It is argued that social issues, in the current steering documents, are downplayed in relation to concepts like “core content” and “knowledge requirements”. The questionnaire that followed showed that teachers had an understanding of social issues that challenged the logic of the previous discourse analysis. They seemed to find it possible to combine “teaching with social issues as the point of departure” with the predefined content and knowledge requirements of the subject syllabus. Based on the results of the final interview study the third article argues that the subject social studies, when seen through the lens of social issues, is one that is open, strives beyond the limitations of  core content and calls for  authentic, sometimes controversial content.

    The conclusion of the licentiate thesis is that the concept of social issues carries the potential to create a subject that is meaningful for students and that challenges the risk of school becoming instrumental.

  • Morén, Göran
    Dalarna University, School of Education, Health and Social Studies, Educational Work. Karlstads universitet, Institutionen för pedagogiska studier.
    "Social Issues Open up Social Studies": Upper Secondary Teachers' Coneptions of, and Didactial Reflections upon the Subject.2017In: Nordidactica: Journal of Humanities and Social Science Education, ISSN 2000-9879, no 2, 1-24 p.Article in journal (Refereed)
    Abstract [en]

    This article identifies and discusses conceptions of the Swedish school subject social studies in upper secondary school through an empirical study consisting of qualitative interviews with seven teachers of social studies. The curriculum declares that teaching social studies shall be done with “social issues as the point of departure”. The analysis focuses on the teachers’ didactical reflections on the subject specific concept of social issues in relation to their own teaching practice. Conclusions that are made are that the approach of teaching social studies with ‘social issues as the  point of departure’ leads to conceptions of social studies as being a subject that is open to the unexpected and that transcends its borders, and with its purpose seen as its content, or put differently: the ‘what’ defined through, or as, its ‘why’. It seems more relevant to discuss what the social issues, as a didactical concept, do to the subject rather than what they are. The very quest for a certain core in the subject is being challenged. A reflection on these results leads to a discussion on the potential intrinsic value of social issues in teaching social studies.  

  • Morén, Göran
    Dalarna University, School of Education, Health and Social Studies, Educational Work. Karlstads universitet, Institutionen för pedagogiska studier.
    Samhällsfrågor i samhällskunskaps­undervisningen2016In: Kapet (elektronisk), E-ISSN 2002-3979, Vol. 12, no 1, 95-115 p.Article in journal (Refereed)
    Abstract [sv]

    Den här artikeln är en del av ett licentiatprojekt om samhällsfrågor som didaktiskt utmaning. Utgångspunkten är begreppet samhällsfrågor, som förekommer i ämnesplanen för samhällskunskap i gymnasieskolan. Detta är den andra delstudien i projektet, som också innehåller en läroplansstudie och en kommande intervjustudie. Empirin för denna artikel utgörs av en enkät med 74 gymnasielärare i samhällskunskap där de fått redogöra för hur de uppfattar begreppet samhällsfrågor som det framträder i styrdokumenten, vilken innebörd det har för och i deras undervisning och hur det förhåller sig till andra centrala begrepp i ämnesplanen, företrädesvis centralt innehåll och förmågor (som ska bedömas enligt kunskapskraven). En grund för analysen hämtas från tidigare forskning och läroplansstudien av begreppet samhällsfrågor, där ett dubbelt spänningsfält gällande såväl undervisningens upplägg som syfte tecknas. Detta spänningsfält ses som utgångspunkten för en möjlig logik. Resultatet visar att det inte var lätt att positionera lärarna utifrån det konstaterade spänningsfältet. Den dominerande bilden från lärarenkäten uppvisar en alternativ logik. Enligt den framhäver man inte spänningen mellan en undervisning med utgångspunkt i frågor och en undervisning med utgångspunkt i ett förutbestämt innehåll. Man tonar också ner spänningen mellan ett syfte i form av utvecklandet av förmågor och ett syfte i form av förmedlandet av ett bestämt innehåll.

  • Public defence: 2017-09-19 10:00 Stora bion, Stockholms dramatiska högskola, Stockholm
    Claesson, Nils
    Stockholm University of the Arts, The Film and Media Department.
    Spökmaskinen: Sju förändringar och förflyttningar – gestaltningsprocesser i animerad film2017Doctoral thesis, monograph (Other academic)
    Abstract [en]

    The Ghost Machine is a practice-based research project that explores the process of embodiment in animated film. It describes the process of transfiguration from the artist’s/auteur’s point of view and not from an outside position. The dissertation follows the embodiment of a dramatic text, the Ghost Sonata by August Strindberg (1907), into an animated film. The starting point is my experience of the drama, at the age of thirteen, when staged by Ingmar Bergman at the Royal Dramatic Theatre. As a teenager, the world of the grown-ups seemed to be corrupt, twisted and ruled by violent power plays and economic sanctions, and this play confirmed my world view. Was I right, as a thirteen-year-old boy? What kind of world emerges in my version of the Ghost Sonata? In this thesis work, the films and the experimental research process meet the practice and art of writing. Using text, not as “theory” separated from “practice” but as a bodily art practice, creates a shifting border between the results and intentions of art and filmmaking, and the results of writing. At the same time a unity emerges where the results of the research process can be seen and experienced in the interaction between the texts and the artwork. The Ghost Machine is a totality where the text, films and artworks included in the project are equally important and must be seen as a unity. The Ghost Machine is a work journey where travelling, animated film practice, networking with colleagues and collecting data are mixed with experiments using methods from contemporary arts practice, performance, reenactment, appropriation and transfiguration, blended with traditional puppet animation in classic Czech style. In collaboration with actors, mime artists, puppet makers, musicians and a minimal film crew, century old stop-motion animation is combined with computer animation.  The textual part of the work falls into two categories: life stories and work stories. The work stories traces the forming of an artwork in all aspects. The life stories are related to the subject of ghosts. Suddenly, dead friends and dear family members claimed their space. The understanding of the Ghost Sonata came to be a process of sorting out and following lines of memory using an inverted version of the Orpheus myth as a guide. Instead of never turning around, when walking the dead out of oblivion, I chose to look back, again and again, until I hit something and could not write anymore.

  • Mattera, Andrea
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    nIGISOL 2016: Measurement of n-induced fission yields of tin and antimony2017Report (Other academic)
    Abstract [en]

    The first run of neutron-induced fission yields measurement at IGISOL-4 was performed from Friday December 9th to Monday December 12th, 2016.

    After mass separation of the fission products with the dipole magnets, ions were implanted on a movable tape and identified using γ-spectroscopy. Measurements were carried out using a Canberra GC7020 70% coaxial p-type HPGe detector.

    In this report, some details of the detector calibration and of the analysis procedure will be described.

  • Almén, Edgar
    et al.
    Linköping University, Department of Religion and Culture. Linköping University, Faculty of Arts and Sciences.
    Furenhed, Ragnar
    Linköping University, Department of Thematic Studies, Health and Society. Linköping University, Faculty of Arts and Sciences.
    Hartman, Sven G.
    Lärarhögskolan, Stockholm.
    Skogar, Björn
    Lärarutbildningen, Karlstad och Södertörn.
    Livstolkning och värdegrund: Att undervisa om religion, livsfrågor och etik2000Book (Other academic)
    Abstract [sv]

    Skolans värdegrund har på senare år lyfts fram i många olika sammanhang. Uppgiften att undervisa om religion, etik, och livsfrågor har också debatterats. Detta undervisningsområde hör till skolans svåraste uppgifter - men kanske också till de viktigaste. Denna antologi ger ett bidrag till utvecklingen av ett professionellt lärarkunnande i frågor som gäller skolans värdegrund och undervisning på livsåskådningsområdet.

    Författarna ger utifrån sina respektive kompetensområden en belysning av några av ämnesområdets centrala aspekter.

    De texter som ingår har skrivits särskilt för lärarutbildningen men kan också användas i andra sammanhang. Avsikten har varit att via texterna föra de studerande i kontakt med såväl aktuell forskning som professionell lärarkunskap av annat slag.

  • Slapak, Rikard
    et al.
    Hamrin, Maria
    Umeå University, Faculty of Science and Technology, Department of Physics.
    Pitkänen, Timo
    Umeå University, Faculty of Science and Technology, Department of Physics.
    Yamauchi, Masatoshi
    Nilsson, Hans
    Karlsson, Tomas
    Schillings, Audrey
    Quantification of the total ion transport in the near-Earth plasma sheet2017In: Annales Geophysicae, ISSN 0992-7689, E-ISSN 1432-0576, Vol. 35, no 4, 869-877 p.Article in journal (Refereed)
    Abstract [en]

    Recent studies strongly suggest that a majority of the observed O+ cusp outflows will eventually escape into the solar wind, rather than be transported to the plasma sheet. Therefore, an investigation of plasma sheet flows will add to these studies and give a more complete picture of magnetospheric ion dynamics. Specifically, it will provide a greater understanding of atmospheric loss. We have used Cluster spacecraft 4 to quantify the H+ and O+ total transports in the near-Earth plasma sheet, using data covering 2001-2005. The results show that both H+ and O+ have earthward net fluxes of the orders of 1026 and 1024 s(-1), respectively. The O+ plasma sheet return flux is 1 order of magnitude smaller than the O+ outflows observed in the cusps, strengthening the view that most ionospheric O+ outflows do escape. The H+ return flux is approximately the same as the ionospheric outflow, suggesting a stable budget of H+ in the magnetosphere. However, low-energy H+, not detectable by the ion spectrometer, is not considered in our study, leaving the complete magnetospheric H+ circulation an open question. Studying tailward flows separately reveals a total tailward O+ flux of about 0 : 5 x w10(25)s(-1), which can be considered as a lower limit of the nightside auroral region O+ outflow. Lower velocity flows (< 100 km s(-1)) contribute most to the total transports, whereas the high-velocity flows contribute very little, suggesting that bursty bulk flows are not dominant in plasma sheet mass transport.

  • Norris, Shane A.
    et al.
    Daar, Abdallah
    Balasubramanian, Dorairajan
    Byass, Peter
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Stellenbosch Univ, Wallenberg Res Ctr, Stellenbosch Inst Adv Study STIAS, Stellenbosch, South Africa.
    Kimani-Murage, Elizabeth
    Macnab, Andrew
    Pauw, Christoff
    Singhal, Atul
    Yajnik, Chittaranjan
    Akazili, James
    Levitt, Naomi
    Maatoug, Jihene
    Mkhwanazi, Nolwazi
    Moore, Sophie E.
    Nyirenda, Moffat
    Pulliam, Juliet R. C.
    Rochat, Tamsen
    Said-Mohamed, Rihlat
    Seedat, Soraya
    Sobngwi, Eugene
    Tomlinson, Mark
    Toska, Elona
    van Schalkwyk, Cari
    Understanding and acting on the developmental origins of health and disease in Africa would improve health across generations2017In: Global Health Action, ISSN 1654-9716, E-ISSN 1654-9880, Vol. 10, no 1, 1334985Article in journal (Refereed)
    Abstract [en]

    Data from many high- and low- or middle-income countries have linked exposures during key developmental periods (in particular pregnancy and infancy) to later health and disease. Africa faces substantial challenges with persisting infectious disease and now burgeoning non-communicable disease. This paper opens the debate to the value of strengthening the developmental origins of health and disease (DOHaD) research focus in Africa to tackle critical public health challenges across the life-course. We argue that the application of DOHaD science in Africa to advance life-course prevention programmes can aid the achievement of the Sustainable Development Goals, and assist in improving health across generations. To increase DOHaD research and its application in Africa, we need to mobilise multisectoral partners, utilise existing data and expertise on the continent, and foster a new generation of young African scientists engrossed in DOHaD.

  • Lind, Karin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy. Max Planck Inst Astron, Germany..
    Amarsi, A. M.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany.;Australian Natl Univ, Res Sch Astron & Astrophys, Cotter Rd, Canberra, ACT 2611, Australia..
    Asplund, M.
    Australian Natl Univ, Res Sch Astron & Astrophys, Cotter Rd, Canberra, ACT 2611, Australia..
    Barklem, Paul S.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astronomy.
    Bautista, M.
    Western Michigan Univ, Dept Phys, Kalamazoo, MI 49008 USA..
    Bergemann, M.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany..
    Collet, R.
    Aarhus Univ, Dept Phys & Astron, Stellar Astrophys Ctr, Ny Munkegade 120, DK-8000 Aarhus C, Denmark..
    Kiselman, D.
    Stockholm Univ, Albanova Univ Ctr, Dept Astron, Inst Solar Phys, SE-10691 Stockholm, Sweden..
    Leenaarts, J.
    Stockholm Univ, Albanova Univ Ctr, Dept Astron, Inst Solar Phys, SE-10691 Stockholm, Sweden..
    Pereira, T. M. D.
    Univ Oslo, Inst Theoret Astrophys, POB 1029, N-0315 Oslo, Norway..
    Non-LTE line formation of Fe in late-type stars - IV. Modelling of the solar centre-to-limb variation in 3D2017In: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 468, no 4, 4311-4322 p.Article in journal (Refereed)
    Abstract [en]

    Our ability to model the shapes and strengths of iron lines in the solar spectrum is a critical test of the accuracy of the solar iron abundance, which sets the absolute zero-point of all stellar metallicities. We use an extensive 463-level Fe atom with new photoionization cross-sections for Fe I and quantum mechanical calculations of collisional excitation and charge transfer with neutral hydrogen; the latter effectively remove a free parameter that has hampered all previous line formation studies of Fe in non-local thermodynamic equilibrium (NLTE). For the first time, we use realistic 3D NLTE calculations of Fe for a quantitative comparison to solar observations. We confront our theoretical line profiles with observations taken at different viewing angles across the solar disc with the Swedish 1-m Solar Telescope. We find that 3D modelling well reproduces the observed centre-to-limb behaviour of spectral lines overall, but highlight aspects that may require further work, especially cross-sections for inelastic collisions with electrons. Our inferred solar iron abundance is log(epsilon(Fe)) = 7.48 +/- 0.04 dex.

  • Whittle, Thomas A.
    et al.
    Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia..
    Brant, William R.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry. Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia..
    Hester, James R.
    Australian Nucl Sci & Technol Org, Kirrawee DC, NSW 2253, Australia..
    Gu, Qinfen
    Australian Synchrotron, 800 Blackburn Rd, Clayton, Vic 3168, Australia..
    Schmid, Siegbert
    Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia..
    Tailoring phase transition temperatures in perovskites via A-site vacancy generation2017In: Dalton Transactions, ISSN 1477-9226, E-ISSN 1477-9234, Vol. 46, no 22, 7253-7260 p.Article in journal (Refereed)
    Abstract [en]

    The structures across the Sr0.8Ti0.6-xZrxNb0.4O3, 0 <= x <= 0.6, defect perovskite series were investigated using complementary synchrotron X-ray and neutron powder diffraction data. The locations of second order compositional and temperature dependent phase transitions between the high symmetry cubic Pm (3) over barm phase and the lower symmetry tetragonal I4/mcm phase were determined. Deviation of the oxygen x coordinate from the high symmetry value and the B-O-B bond angle from 180 degrees as well as the tetragonal strain squared were each found to be suitable order parameters to monitor the transitions. Tolerance factor calculations confirmed that these A-site deficient perovskites retain a higher symmetry to a lower value than their fully occupied counterparts. Therefore, adjusting vacancy concentrations can be employed as a general strategy to design compounds with specifically tailored phase transition temperatures.

  • Aaboud, M.
    et al.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Maddocks, H. J.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, H.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Search for new phenomena in events containing a same-flavour opposite-sign dilepton pair, jets, and large missing transverse momentum in √s = 13 TeV pp collisions with the ATLAS detector2017In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 77, no 3, 144Article in journal (Refereed)
    Abstract [en]

    Two searches for new phenomena in final states containing a same-flavour opposite-sign lepton (electron or muon) pair, jets, and large missing transverse momentum are presented. These searches make use of proton-proton collision data, collected during 2015 and 2016 at a centre-of-mass energy root s = 13 TeV by the ATLAS detector at the large hadron collider, which correspond to an integrated luminosity of 14.7 fb(-1). Both searches target the pair production of supersymmetric particles, squarks or gluinos, which decay to final states containing a same-flavour opposite-sign lepton pair via one of two mechanisms: a leptonically decaying Z boson in the final state, leading to a peak in the dilepton invariant-mass distribution around the Z boson mass; and decays of neutralinos (e.g.. (chi) over tilde (0)(2) -> l(+)l(-1)(chi) over tilde (0)(1)), yielding a kinematic endpoint in the dilepton invariant-mass spectrum. The data are found to be consistent with the Standard Model expectation. Results are interpreted in simplified models of gluino-pair (squark-pair) production, and provide sensitivity to gluinos (squarks) with masses as large as 1.70 TeV (980 GeV).

  • Fredriksson, Mio
    et al.
    Eriksson, Max
    Umeå University, Faculty of Social Sciences, Department of Political Science.
    Tritter, Jonathan
    Who wants to be involved in health care decisions?: Comparing preferences for individual and collective involvement in England and Sweden2017In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 18, 18Article in journal (Refereed)
    Abstract [en]

    Background: Patient and public involvement (PPI) is framed as positive for individuals, the health system, public health, as well as for communities and society as a whole. We investigated whether preferences for PPI differed between two countries with Beveridge type health systems-Sweden and England. We measured willingness to be involved in individual treatment decisions and in decisions about the organization and provision of local health and social care services. Methods: This was a comparative cross-sectional study of the general population's preferences. Together, the two samples included 3125 respondents; 1625 in England and 1500 in Sweden. Country differences were analysed in a multinomial regression model controlling for gender, age and educational attainment. Results: Overall, 68% of respondents wanted a passive patient role and 44% wanted to be involved in local decisions about organization and provision of services. In comparison with in Sweden, they were in England less likely to want a health professional such as a GP or consultant to make decisions about their treatment and also more likely to want to make their own decisions. They were also less likely to want to be involved in local service development decisions. An increased likelihood of wanting to be involved in organizational decision-making was associated with individuals wanting to make their own treatment decisions. Women were less likely to want health professionals to make decisions and more likely to want to be involved in organizational decisions. Conclusions: An effective health system that ensures public health must integrate an effective approach to PPI both in individual treatment decisions and shaping local health and social care priorities. To be effective, involvement activities must take in to account the variation in the desire for involvement and the implications that this has for equity. More work is needed to understand the relationship between the desire to be involved and actually being involved, but both appear related to judgements of the impact of involvement on health care decisions.

  • Koller-Smith, Louise I. M.
    et al.
    Shahr, Prakesh S.
    Ye, Xiang Y.
    Sjoers, Gunnar
    Wang, Yueping A.
    Chow, Sharon S. W.
    Darlow, Brian A.
    Lee, Shoo K.
    Håkansson, Stellan
    Umeå University.
    Lui, Kei
    Comparing very low birth weight versus very low gestation cohort methods for outcome analysis of high risk preterm infants2017In: BMC Pediatrics, ISSN 1471-2431, E-ISSN 1471-2431, Vol. 17, 166Article in journal (Refereed)
    Abstract [en]

    Background: Compared to very low gestational age (<32 weeks, VLGA) cohorts, very low birth weight (<1500 g; VLBW) cohorts are more prone to selection bias toward small-for-gestational age (SGA) infants, which may impact upon the validity of data for benchmarking purposes. Method: Data from all VLGA or VLBW infants admitted in the 3 Networks between 2008 and 2011 were used. Two-thirds of each network cohort was randomly selected to develop prediction models for mortality and composite adverse outcome (CAO: mortality or cerebral injuries, chronic lung disease, severe retinopathy or necrotizing enterocolitis) and the remaining for internal validation. Areas under the ROC curves (AUC) of themodels were compared. Results: VLBW cohort (24,335 infants) had twice more SGA infants (20.4% vs. 9.3%) than the VLGA cohort (29,180 infants) and had a higher rate of CAO (36.5% vs. 32.6%). The two models had equal prediction power for mortality and CAO (AUC 0.83), and similarly for all other cross-cohort validations (AUC 0.81-0.85). Neither model performed well for the extremes of birth weight for gestation (<1500 g and >= 32 weeks, AUC 0.50-0.65; >= 1500 g and >= 32 weeks, AUC 0.60-0.62). Conclusion: There was no difference in prediction power for adverse outcome between cohorting VLGA or VLBW despite substantial bias in SGA population. Either cohorting practises are suitable for international benchmarking.

  • Public defence: 2017-09-15 10:15 Planck, Fysikhuset, Linköping
    Bengtsson, Katarina
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, Faculty of Science & Engineering.
    Electrokinetic devices from polymeric materials2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    There are multiple applications for polymers: our bodies are built of them, plastic bags and boxes used for storage are composed of them, as are the shells for electronics, TVs, computers, clothes etc. Many polymers are cheap, and easy to manufacture and process which make them suitable for disposable systems. The choice of polymer to construct an object will therefore highly influence the properties of the object itself. The focus of this thesis is the application of commonly used polymers to solve some challenges regarding integration of electrodes in electrokinetic devices and 3D printing.

    The first part of this thesis regards electrokinetic systems and the electrodes’ impact on the system. Electrokinetic systems require Faradaic (electrochemical) reactions at the electrodes to maintain an electric field in an electrolyte. The electrochemical reactions at the electrodes allow electron-to-ion transduction at the electrode-electrolyte interface, necessary to drive a current at the applied potential through the system, which thereby either cause flow (electroosmosis) or separation (electrophoresis). These electrochemical reactions at the electrodes, such as water electrolysis, are usually problematic in analytical systems and systems applied in biology. One solution to reduce the impact of water electrolysis is by replacing metal electrodes with electrochemically active polymers, e.g. poly(3,4-ethylenedioxythiophene) (PEDOT). Paper 1 demonstrates that PEDOT electrodes can replace platinum electrodes in a gel electrophoretic setup. Paper 2 reports an all-plastic, planar, flexible electroosmotic pump which continuously transports water from one side to the other using potentials as low as 0.3 V. This electroosmotic pump was further developed in paper 3, where it was made into a compact and modular setup, compatible with commercial microfluidic devices. We demonstrated that the pump could maintain an alternating flow for at least 96 h, with a sufficient flow of cell medium to keep cells alive for the same period of time.

    The second part of the thesis describes the use of 3D printers for manufacturing prototypes and the material requirements for 3D printing. Protruding and over-hanging structures are more challenging to print using a 3D printer and usually require supporting material during the printing process. In paper 4, we showed that polyethylene glycol (PEG), in combination with a carbonate-based plasticizer, functions well as a 3D printable sacrificial template material. PEG2000 with between 20 and 30 wt% dimethyl carbonate or propylene carbonate have good shear-thinning rheology, mechanical and chemical stability, and water solubility, which are advantageous for a supporting material used in 3D printing.

    The advances presented in this thesis have solved some of the challenges regarding electrokinetic systems and prototype manufacturing. Hopefully this will contribute to the development of robust, disposable, low-cost, and autonomous electrokinetic devices.

  • Public defence: 2017-09-29 10:00 Östersund
    Prince, Solene
    Mid Sweden University, Faculty of Human Sciences, Department of Tourism Studies and Geography.
    Imagining Tourist Spaces as Living Spaces: Towards a Relational Approach to Alternatives and Morals in Tourism2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Many actors are taking advantage of the flexible barriers to entry of the tourist industry to engage in the production of varied forms of tourism closely related to their lifestyle, professional and communal ambitions. With the increased popularity of forms of tourism bringing the guest close to the host, it becomes relevant to ask questions related to lived experiences and close encounters in tourism scholarship. This is a moral conviction that the plurality of human experiences and critical reflexivity matter in the conception of tourist spaces and their management. In this thesis, I look for new ways to conceptually embed local people in their living spaces by approaching forms of tourism displaying non-economic elements as phenomena that create new and complex relations imbued with various implications. Tourism geography highlights the negotiated and fragmented nature of tourism, and its performative and embodied character. I apply relational geography to apprehend the multiple relations that make up local spaces and identities. With its post-structural character, relational geography uncovers voices once neglected in research, and proposes new ways of being in the world. My two qualitative case studies reflect my interest in exploring the northern European context. Firstly, I investigate craft-artists on Bornholm, Denmark and their relation to the tourist season. I do this through interviews and narrative analysis. My second case study, a focused ethnography at Sólheimar eco-village, Iceland, centres on the management of host and guest interactions.  In terms of spatial formation, results show that local actors have the agency to form networks and redefine their identities in the wake of tourism development. They form a hybrid space by fulfilling goals related to their lifestyle, livelihood and professional ambitions simultaneously. Moreover, mundane practices are presented as an integral part of a tourist landscape. In terms of management, results show that the various spatial complexities faced by communities exacerbate host and guest relations. This will require a commitment from local coordinators and managers to promote a reflexive and critical exchange during these close encounters. I ultimately argue for the imagination of tourist spaces as living spaces, where I conceptualize tourism as a mundane, yet complex, material and social experience for those living in tourist spaces. I propose two new discursive anchors that reflect the metaphor of the living space: dwelling in the tourist landscape, and sincere encounters. I contend that researching living spaces finds its moral grounds in its openness to the various ways local people dwell and encounter during tourism, and to the diverse ways researchers make sense of these practices, and of their own.

  • Elgh, Fredrik
    et al.
    Jönköping University, School of Engineering, JTH, Product Development.
    André, Samuel
    Jönköping University, School of Engineering, JTH, Product Development.
    Johansson, Joel
    Jönköping University, School of Engineering, JTH, Product Development.
    Stolt, Roland
    Jönköping University, School of Engineering, JTH, Product Development.
    Design Platform: A Coherent Model for Management and Use of Mixed Design Assets2017In: Transdisciplinary Engineering: A Paradigm Shift: Proceedings of the 24th ISPE Inc. International Conference on Transdisciplinary Engineering / [ed] Chen, C.-H., Trappey, A.C., Peruzzini, M., Stjepandić, J., Wognum, N., IOS Press, 2017, no 3-4, 703-712 p.Conference paper (Refereed)
    Abstract [en]

    For many companies, it is a challenge to balance product variety and cost, i.e. external and internal efficiency. Product platforms has been the dominant solution for a business targeting mass-customization. The main idea is to dived the product into modules that can be shared among different product variants. This has been a success on the consumer market, however, many manufacturing companies are engineer-to-order (ETO) oriented, such as original equipment suppliers (OES). They design a unique solution, often in close collaboration with other companies, based on different product concepts and/or core technologies. For these companies, there is a strategic need for a platform model influenced by the principles of masscustomization, although, not limited to only include modules. In this work, a novel platform model, called Design Platform is described. The model has been developed and applied in cooperation with four companies. The Design Platform provides a coherent environment for management of heterogeneous design assets to be used in product development and supports an improved ability to master fluctuating requirements and systematic introduction of new technologies.

  • Nordström, B.
    et al.
    SCA R&D Centre, Sundsvall, Sweden.
    Hermansson, Lennart
    RISE - Research Institutes of Sweden, Bioeconomy.
    Effect of fiber length on formation and strength efficiency in twin-wire roll forming2017In: Nordic Pulp & Paper Research Journal, ISSN 0283-2631, E-ISSN 2000-0669, Vol. 32, no 1, 119-125 p.Article in journal (Refereed)
    Abstract [en]

    A change in fiber length is known to change fiber flocculation and formation of machine-made paper, but it has been unclear how a change in formation through fiber length affects strength efficiency. (The strength efficiency reflects how well the furnish strength, as indicated by the handsheet strength, is utilized in the machine-made paper.) The effect of fiber length on strength efficiency in twin-wire roll forming was presently investigated by examining two furnishes with different average fiber length, prepared from the same batch of softwood kraft pulp, over a wide range of headbox consistencies on a pilot machine. An increase in fiber length resulted not only in worse Ambertec formation over the whole range of headbox consistencies but also in faster relative deterioration of the formation with increasing consistency. Tensile strength efficiency and Z-strength efficiency were both reduced when the formation was impaired through increased fiber length, and the effect was similar to the effect of a corresponding change in formation through headbox consistency. A given change in formation, through fiber length or headbox consistency, had a larger relative effect on Z-strength efficiency than on tensile strength efficiency.

  • Wihlborg, Elin
    et al.
    Linköping University, Department of Management and Engineering, Political Science. Linköping University, Faculty of Arts and Sciences.
    Norstedt, Anna
    Linköping University.
    New ways and actors when diplomacy goes digital: The e-Diplomacy Campaign “Midwives4All2017In: Proceedings of the 50th Hawaii International Conference on System Sciences, 2017, Waikoloa: University of Hawaii , 2017, 2438-2447 p.Conference paper (Refereed)
    Abstract [en]

    This article focuses on Midwives4All, an e-diplomacy campaign launched by the Swedish MFA in 2015. The campaign aims to spread knowledge about the benefits of midwives and evidence-based midwifery. Within the campaign, the Swedish MFA, and in particular its Communications Department (UD-KOM), combines e-diplomacy and networking and the campaign has become one key activity within the Swedish feminist foreign policy. It is organizing diplomacy in new ways that regards both choices of channels and the networking with inter- and nongovernmental organizations. The limited impacts of the campaign are seen as consequences of the peripheral status of the issue and the lack of systematic structures for e-diplomacy so far. In spite of this the case indicates that e-diplomacy has the potential to raise and empower both new actor groups and new issues on the diplomatic agenda.

  • Public defence: 2017-09-08 09:00 Sal IX, Gamla universitetshuset, Uppsala
    Thorsell Cederberg, Jenny
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Acceptance for persons suffering from pain: Evaluation of acceptance-based interventions for adults with chronic pain and children with cancer experiencing acute pain2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    It is increasingly clear that pain and emotions are closely interconnected. Pain does not only cause psychological distress, but psychological distress also amplifies pain through neurological mechanisms. Treatment of both chronic and acute pain would benefit from acknowledging the psychological mechanisms of pain neurophysiology. Psychological acceptance predicts increased pain tolerance and decreased pain intensity and discomfort in experimentally induced pain and improved physical and psychosocial functioning for persons with chronic pain.

    The overall aim of this thesis was to evaluate acceptance-based interventions for persons suffering from pain.

    In Study I the effect of a manualised ACT-based self-help intervention for adults with chronic pain was evaluated in an RCT (n=90). The results showed improvements in satisfaction with life, physical functioning and pain intensity for the ACT group. Both the ACT and the control group improved regarding depression and anxiety. In Study II the mediating effect of acceptance for treatment change was evaluated, using data from Study I (n=64). The results showed indirect effects of treatment via acceptance for physical functioning but not for satisfaction with life. In Studies III and IV, instruments to measure psychological flexibility in relation to pain were developed for children with cancer, and their parents respectively, using factor analysis. The results showed that a two-factor solution for the child scale (n=61) and a three-factor solution for the parent scale (n=243), best represented the data. In Study V, an acceptance-based intervention was preliminarily evaluated in a single-subject study (n=5) for children reporting pain during cancer treatment. The intervention consisted of an approximately 15-minute long pain exposure exercise. All participants reported reduced discomfort of pain, and three of the participants reported reduced pain intensity.

    The results suggest that a manualised ACT-based self-help intervention is a valuable addition to the treatment repertoire for persons with chronic pain and that acceptance may mediate the effect of treatment on physical functioning. Furthermore, instruments to measure acceptance in the context of acute pain in children with cancer are now available, although further validation is needed. Lastly, the results indicate that an acceptance-based intervention may help children undergoing cancer treatment to cope with pain.

  • Public defence: 2017-09-08 16:37 Hörsal C (C0E11), Malmö
    Snodgrass, Eric
    Malmö University.
    Executions: Power and Expression in Networked and Computational Media2017Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This research looks at questions of power and expression as they are composed in various ways within networked and computationally-informed situations of the present. Drawing from the term as it is originally invoked in practices of computing, the research puts forward execution as a central conceptual framework for its investigations. In a computer program, a program becomes executable when it is able to execute a set of procedures within a designated set of relations and affordances. Similarly, the concept of execution developed here looks at the ongoing negotiations of various formative relations and affordances (technical, cultural, material, political) in practices of execution, describing certain notable techniques applied towards the task of making things executable.

    The examples looked at include several dominant media and technology practices of the present, as well as several alternative practices that point to other possible modes of execution. In doing so, the research highlights certain politically-orientated issues involved in questions of execution, working to further develop specific approaches aimed at describing, questioning and intervening into practices of execution as they occur in the world.

  • Public defence: 2017-09-08 13:00 Weber, Växjö
    Lindeblad, Emma
    Linnaeus University, Faculty of Health and Life Sciences, Department of Psychology. Linnéuniversitetet.
    Self-concepts and psychological health among children and adolescents with reading disabilities and the influence of assistive technology2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis includes three empirical studies that have all aimed to increase the understanding of the interactions and connections between self-concepts, reading impairment, psychological health and Assistive Technology (AT). The use of applications in tablets as assistive technology to facilitate reading and compensate for reading impairment and its impact on the participants’ self-concepts and psychological health as well as on their reading abilities was also of interest.

    The first study included 67 pupils in school years 4-9. They were assessed by the Beck Youth Inventory (BYI) regarding self-image, anxiety and depression. The results showed no deviance from age-equivalent norm group scores. The second study included 35 pupils in school years 4-6. This study aimed at investigating the transfer effects on decoding and general reading ability after 20 intervention sessions where AT (applications in tablets) were used. Results showed that the decoding ability had progressed at the same rate as that of the norm group. The results also showed that using AT increased motivations to learn, as well as independence and improved family climate. The third study was a randomized control study (RCT) with 137 participants in school years 4, 8 and high school. The results showed that reading impaired children and adolescents to a great extent, but not completely unanimously, did not depict any different self-image or self-esteem than peers with an expected reading ability of the same age. Self-esteem was investigated by the Cultural Free Self Esteem Inventory (CFSEI-3). The CFSEI-3 scores showed no effect by interventions with AT. The results also showed that there were no signs of depression, assessed by BYI, in the investigated groups, but somewhat inconclusive results regarding anxiety where the school-year 4 group depicted higher levels of anxiety.

    The results generally showed a more positive depiction than what previous studies within the field have presented, which was interpreted as being due to the development of efficient pedagogical strategies and supportive attitudes in the school context, as well as among family members or peers. 

  • Public defence: 2017-09-08 09:00 KB.E3.03 (stora hörsalen), KBC-huset, Umeå
    Lindgren, Cecilia
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Design strategies for new drugs targeting multicomponent systems: focusing on class II MHC proteins and acetylcholinesterase2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The field of medicinal chemistry is constantly evolving. Aided by advances within techniques as well as knowledge of biological systems, increasingly complex targets and drugs can be considered. This thesis includes two projects focusing on the design of drugs targeting multicomponent systems, referring to systems for which multiple components must be considered during the drug design process.

    In the first project, the long-term goal is to develop a vaccine against the autoimmune disease rheumatoid arthritis (RA). The cause of RA is unknown, but it is genetically linked to expression of class II MHC proteins that present antigens to T-cell receptors (TCRs), responsible for initiating an immune response. A glycopeptide fragment, CII259–273, from type II collagen has shown promising results as a vaccine against arthritis resembling RA in mice. CII259–273 binds to the class II MHC protein followed by presentation to the TCR, forming a multicomponent system.

    We have used molecular dynamics (MD) simulations to study the effect that modifications of CII259–273 have on the multicomponent system. Non-native amino acids and amide bond isosteres have been introduced. This has demonstrated the importance of retaining the backbone conformation of CII259–273, as well as the hydrogen bonds formed to the backbone. The ability to introduce such modifications would be of value to affect the potency towards the MHC protein, and prevent degradation of the glycopeptide. The studies have revealed a multicomponent system that is highly sensitive to even small modifications that can affect the dynamics of the entire complex.

    In the second project, the long-term goal is to develop a broad-spectrum antidote against nerve agents. Nerve agents are extremely toxic compounds that act by covalently inhibiting the enzyme acetylcholinesterase (AChE), which is essential for termination of nerve signalling. A major limitation of current antidotes is that their efficiency is dependent on the type of nerve agent. A broad-spectrum antidote must be able to bind to the multicomponent system consisting of AChE covalently inhibited by different nerve agents. It will then act by performing a nucleophilic attack on the nerve agent adduct, thus breaking the covalent bond to AChE.

    We have used statistical molecular design (SMD) and quantitative structure-activity relationship (QSAR) modelling to identify a fragment with a potency for AChE inhibited by different nerve agents. A nucleophilic component able to restore the enzyme to the active form was thereafter introduced. This resulted in a functional reactivator, efficient for multiple nerve agents. Furthermore, the mechanism of reactivation has been investigated through structural studies, enabled by a combination of X-ray crystallography and molecular modelling. A high flexibility of the reactivator, as well as the ability to bind to AChE in multiple conformations, are defined as important properties for a broad-spectrum antidote.

  • Public defence: 2017-09-08 10:00 Föreläsningssal 5, Falun
    Borg, Farhana
    Umeå University, Faculty of Social Sciences, Department of applied educational science. Högskolan Dalarna.
    Caring for people and the planet: preschool children’s knowledge and practices of sustainability2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Children across the globe today are continuously being exposed to and affected by various kinds of real-world complexities and challenges; however, research on their knowledge and practices in terms of sustainability is limited, in particular with regards to how preschool- and home-related factors are associated with their learning for sustainability. Since 1998, different types of eco-certification have been awarded by the Swedish National Agency for Education and Keep Sweden Tidy Foundation to promote education for sustainability (EfS) in all areas of education and learning. Despite certificates having been granted in Sweden since 1998, no studies have been conducted at the national level to investigate whether eco-certification has any role to play in children’s learning for environmental and sustainability issues. This knowledge is important to develop pedagogical activities to engage young children meaningfully in learning for sustainability at preschool. This study was undertaken so as to address this research gap in a Swedish context.

    The overall aim of this study was to enhance the existing knowledge about preschool children’s learning for sustainability in Sweden. The objectives of this study have been to investigate and compare the knowledge and self-reported practices of sustainability among children attending eco-certified and non-eco-certified preschools, respectively, and to explore the extent to which preschool- and home-related factors are associated with children’s knowledge and practices of sustainability. Further, this study explored children’s perceived sources of such knowledge. The term ‘knowledge’ in this text refers to the descriptions of children’s ideas and thoughts. Similarly, eco-certified preschool refers to a school that work explicitly with EfS.

    The study was designed from a "child’s perspective": this means that it was designed by adults to understand children’s perceptions and actions. Bandura’s (1977) social learning theory and Bruner’s (1961) iconic (image-based) modes of representation were applied in various stages of the study. A conceptual framework was developed within the three-interlocking-circles model of sustainability that illustrates how environmental, social and economic dimensions are interconnected. The concept of sustainability was operationalized in four themes: economic equality, resource sharing, recycling and transport use.

    With the use of illustrations and semi-structured questions, final-year preschool children (n=53), aged five to six years, and the directors (n=7) at six eco-certified and six non-eco-certified preschools were interviewed, while guardians (n=89) and teachers (n=74) filled out questionnaires. Qualitative and quantitative data were analyzed using content analysis and Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA), respectively. The quality and complexity of children’s responses were assessed and classified using the SOLO Taxonomy (Biggs & Collis, 1982).

    The results showed that by the time the children completed preschool, many had acquired some knowledge about how to use money, about the sorting of different recyclable items at home and at preschool, and about the impact of different modes of transport on the environment and people’s lives. They also had ideas about the lives of other children in the world and what it can mean to share resources with other people. There was a positive relationship between children’s declarative (understanding) and functional (practice) knowledge of sustainability issues and the involvement of teachers and guardians in sustainability-related discussions and activities. No statistically significant differences between eco-certified and non-eco-certified preschools in terms of children’s declarative and functional knowledge were found. Parents were reported to be the main sources of children’s knowledge along with the children themselves, teachers and media.

    The findings offer support for integrating environmental, social and economic dimensions of sustainability into the daily pedagogical activities of preschools and for giving children opportunities to participate in discussions and practical activities that concern their lives. Further studies are needed to investigate the extent to which different educational activities contribute to developing children’s understanding and behavior when it comes to a sustainable society.

  • Public defence: 2017-09-01 09:00 Sal 135, byggnad 9 A, Allmänmedicin, Umeå
    Muindi, Kanyiva
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Air pollution in Nairobi slums: sources, levels and lay perceptions2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Background

    Air quality in Africa has remained a relatively under-researched field. Most of the African population is dependent on biomass for cooking and heating, with most of the combustion happening in low efficiency stoves in unvented kitchens. The resulting high emissions are compounded by ingress from poor outdoor air in a context of poor emissions controls. The situation is dire in slum households where homes are crowded and space is limited, pushing households to cook in the same room that is used for sleeping. This study assessed the levels of particulate matter with aerodynamic diameter £ 2.5 microns (PM2.5) in slum households and people's perceptions of and attitudes towards air pollution and health risks of exposure in two slum areas, Viwandani and Korogocho, in the Nairobi city.

    Methods

    The study employed both qualitative and quantitative methods. For the quantitative study, we used structured questionnaires to collect data about the source of air pollution among adults aged 18 years and above and pregnant women residing in the two study communities. We used the DustTrak™ air samplers to monitor the indoor PM2.5 levels in selected households. We also collected data on community perceptions on air pollution, annoyance and associated health risks. We presented hotspot maps to portray the spatial distribution of perceptions on air pollution in the study areas. For the qualitative study, we conducted focus group discussions with adult community members. Groups were disaggregated by age to account for different languages used to communicate with the younger and older people. We analysed the qualitative data using thematic analysis.

    Results

    Household levels of PM2.5 varied widely across households and ranged from 1 to 12,369μg/m3 (SD=287.11). The household levels of PM2.5 levels were likely to exceed the WHO guidelines given the high levels observed in less than 24 hours of monitoring periods (on average 10.4 hours in Viwandani and 11.8 hours in Korogocho). Most of the respondents did not use ventilation use in the evening which coincided with the use of cookstove and lamp, mostly burning kerosene. The levels of PM2.5 varied by the type of fuels, with the highest emissions in households using kerosene for cooking and lighting. The PM2.5 levels spiked in the evenings and during periods of cooking using charcoal/wood. Despite these high levels, residents perceived indoor air to be less polluted compared with the outdoor air, possibly due to the presence of large sources of emissions near the communities such as dumpsites and industries. The community had mixed perceptions on the health impacts of air pollution, with respiratory illnesses perceived as the main consequence while vector or sanitation related diseases such as diarrhoea was also perceived to be related to air pollution.

    Conclusions

    With poor housing and reliance on dirty fuels, households in slums face potentially high levels of exposure to PM2.5 with dire implications on health. To address the poor perception on air pollution and knowledge gaps on the health effects of air pollution, education programs need to be developed and tailored. These programs should aim to provide residents with information on air quality and its impact on the health; what they can do as communities as well as empower them to reach out to government/stakeholders for action on outdoor sources of pollution such as emissions from dumpsites or industries. The government has a larger role in addressing some of the key pollution sources through policy formulation and strong implementation/enforcement.

  • Rögnvaldsson, Thorsteinn
    et al.
    Halmstad University, School of Information Technology, Halmstad Embedded and Intelligent Systems Research (EIS), CAISR - Center for Applied Intelligent Systems Research.
    Nowaczyk, Sławomir
    Halmstad University, School of Information Technology, Halmstad Embedded and Intelligent Systems Research (EIS), CAISR - Center for Applied Intelligent Systems Research.
    Byttner, Stefan
    Halmstad University, School of Information Technology, Halmstad Embedded and Intelligent Systems Research (EIS), CAISR - Center for Applied Intelligent Systems Research.
    Prytz, Rune
    Halmstad University, School of Information Technology, Halmstad Embedded and Intelligent Systems Research (EIS), CAISR - Center for Applied Intelligent Systems Research. Volvo Group Trucks Technology.
    Magnus, Svensson
    Halmstad University, School of Information Technology, Halmstad Embedded and Intelligent Systems Research (EIS), CAISR - Center for Applied Intelligent Systems Research.
    Self-monitoring for maintenance of vehicle fleets2017In: Data mining and knowledge discovery, ISSN 1384-5810, E-ISSN 1573-756XArticle in journal (Refereed)
    Abstract [en]

    An approach for intelligent monitoring of mobile cyberphysical systems is described, based on consensus among distributed self-organised agents. Its usefulness is experimentally demonstrated over a long-time case study in an example domain: a fleet of city buses. The proposed solution combines several techniques, allowing for life-long learning under computational and communication constraints. The presented work is a step towards autonomous knowledge discovery in a domain where data volumes are increasing, the complexity of systems is growing, and dedicating human experts to build fault detection and diagnostic models for all possible faults is not economically viable.

    The embedded, self-organised agents operate on-board the cyberphysical systems, modelling their states and communicating them wirelessly to a back-office application. Those models are subsequently compared against each other to find systems which deviate from the consensus. In this way the group (e.g. a fleet of vehicles) is used to provide a standard, or to describe normal behaviour, together with its expected variability under particular operating conditions. The intention is to detect faults without the need for human experts to anticipate them beforehand. This can be used to build up a knowledge base that accumulates over the life-time of the systems. The approach is demonstrated using data collected during regular operation of a city bus fleet over the period of almost four years.

  • Minici, Claudia
    et al.
    IRCCS San Raffaele Sci Inst, Div Immunol Transplantat & Infect Dis, Biocrystallog Unit, Via Olgettina 58, I-20132 Milan, Italy.;Univ Vita Salute San Raffaele, I-20132 Milan, Italy..
    Gounari, Maria
    IRCCS San Raffaele Sci Inst, Div Expt Oncol, Cell Neoplasia Unit B, I-20132 Milan, Italy..
    Uebelhart, Rudolf
    Univ Klin Ulm, D-89081 Ulm, Germany..
    Scarfo, Lydia
    Univ Vita Salute San Raffaele, I-20132 Milan, Italy.;IRCCS San Raffaele Sci Inst, Div Expt Oncol, Cell Neoplasia Unit B, I-20132 Milan, Italy.;IRCCS San Raffaele Sci Inst, Strateg Res Program CLL, I-20132 Milan, Italy..
    Duhren-von Minden, Marcus
    Univ Klin Ulm, D-89081 Ulm, Germany..
    Schneider, Dunja
    Albert Ludwigs Univ Freiburg, Fac Biol, Ctr Biol Signaling Studies, D-79104 Freiburg, Germany..
    Tasdogan, Alpaslan
    Univ Klin Ulm, D-89081 Ulm, Germany..
    Alkhatib, Alabbas
    Albert Ludwigs Univ Freiburg, Fac Biol, Ctr Biol Signaling Studies, D-79104 Freiburg, Germany..
    Agathangelidis, Andreas
    IRCCS San Raffaele Sci Inst, Div Expt Oncol, Cell Neoplasia Unit B, I-20132 Milan, Italy..
    Ntoufa, Stavroula
    Ctr Res & Technol, Inst Appl Biosci, Thessaloniki 57001, Greece..
    Chiorazzi, Nicholas
    Feinstein Inst Med Res, Manhasset, NY 11030 USA..
    Jumaa, Hassan
    Univ Klin Ulm, D-89081 Ulm, Germany..
    Stamatopoulos, Kostas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. Ctr Res & Technol, Inst Appl Biosci, Thessaloniki 57001, Greece..
    Ghia, Paolo
    Univ Vita Salute San Raffaele, I-20132 Milan, Italy.;IRCCS San Raffaele Sci Inst, Div Expt Oncol, Cell Neoplasia Unit B, I-20132 Milan, Italy.;IRCCS San Raffaele Sci Inst, Strateg Res Program CLL, I-20132 Milan, Italy..
    Degano, Massimo
    IRCCS San Raffaele Sci Inst, Div Immunol Transplantat & Infect Dis, Biocrystallog Unit, Via Olgettina 58, I-20132 Milan, Italy..
    Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia2017In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, 15746Article in journal (Refereed)
    Abstract [en]

    Cell-autonomous B-cell receptor (BcR)-mediated signalling is a hallmark feature of the neoplastic B lymphocytes in chronic lymphocytic leukaemia (CLL). Here we elucidate the structural basis of autonomous activation of CLL B cells, showing that BcR immunoglobulins initiate intracellular signalling through homotypic interactions between epitopes that are specific for each subgroup of patients with homogeneous clinicobiological profiles. The molecular details of the BcR-BcR interactions apparently dictate the clinical course of disease, with stronger affinities and longer half-lives in indolent cases, and weaker, short-lived contacts mediating the aggressive ones. The diversity of homotypic BcR contacts leading to cell-autonomous signalling reconciles the existence of a shared pathogenic mechanism with the biological and clinical heterogeneity of CLL and offers opportunities for innovative treatment strategies.

  • Cao, Yiming
    et al.
    Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Photon & Interfaces, CH-1015 Lausanne, Switzerland..
    Saygili, Yasemin
    Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Photomol Sci, CH-1015 Lausanne, Switzerland..
    Ummadisingu, Amita
    Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Photon & Interfaces, CH-1015 Lausanne, Switzerland..
    Teuscher, Joel
    Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Photochem Dynam Grp, CH-1015 Lausanne, Switzerland..
    Luo, Jingshan
    Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Photon & Interfaces, CH-1015 Lausanne, Switzerland..
    Pellet, Norman
    Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Photon & Interfaces, CH-1015 Lausanne, Switzerland..
    Giordano, Fabrizio
    Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Photon & Interfaces, CH-1015 Lausanne, Switzerland..
    Zakeeruddin, Shaik Mohammed
    Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Photon & Interfaces, CH-1015 Lausanne, Switzerland..
    Moser, Jacques-E.
    Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Photochem Dynam Grp, CH-1015 Lausanne, Switzerland..
    Freitag, Marina
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry. Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Photomol Sci, CH-1015 Lausanne, Switzerland..
    Hagfeldt, Anders
    Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Photomol Sci, CH-1015 Lausanne, Switzerland..
    Graetzel, Michael
    Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Photon & Interfaces, CH-1015 Lausanne, Switzerland..
    11% efficiency solid-state dye-sensitized solar cells with copper(II/I) hole transport materials2017In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, 15390Article in journal (Refereed)
    Abstract [en]

    Solid-state dye-sensitized solar cells currently suffer from issues such as inadequate nanopore filling, low conductivity and crystallization of hole-transport materials infiltrated in the mesoscopic TiO2 scaffolds, leading to low performances. Here we report a record 11% stable solid-state dye-sensitized solar cell under standard air mass 1.5 global using a hole-transport material composed of a blend of [Cu (4,4',6,6'-tetramethyl-2,2'-bipyridine)2(bis(trifluoromethylsulfonyl)imide)2 and [Cu (4,4',6,6'-tetramethyl-2,2'-bipyridine)2](bis(trifluoromethylsulfonyl)imide). The amorphous Cu(II/I) conductors that conduct holes by rapid hopping infiltrated in a 6.5 mm-thick mesoscopic TiO2 scaffold are crucial for achieving such high efficiency. Using time-resolved laser photolysis, we determine the time constants for electron injection from the photoexcited sensitizers Y123 into the TiO2 and regeneration of the Y123 by Cu(I) to be 25 ps and 3.2 μs, respectively. Our work will foster the development of low-cost solid-state photovoltaic based on transition metal complexes as hole conductors.

  • Ahlin, Jesper
    Philosophy and History, KTH, School of Architecture and the Built Environment (ABE), Philosophy and History of Technology, Philosophy.
    Toward an Agent-Centered Theory of VoluntarinessManuscript (preprint) (Other academic)
    Abstract [en]

    The concept of voluntariness is central to informed consent and personal autonomy, yet it has been underexplored by bioethicists. There are various theories intended to explain voluntary choice and action. None is fully agent-centered, in the sense that the conceptualization of voluntariness takes into account the agent’s views of her decisions and actions. An agent-centered theory of voluntariness would promote analytical precision, and foster autonomy in healthcare and research practices. According to the most influential bioethical theory of voluntariness, here called the Voluntariness as Control theory, an action is non-voluntary if the agent is controlled by external influences. The theory is critically discussed from an agent-centered perspective, and a new conceptualization of voluntariness is proposed.

  • Nygren, Karina
    et al.
    Umea Univ, Dept Publ Hlth & Clin Med, SE-90187 Umea, Sweden..
    Hammarström, Anne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. Umea Univ, Dept Publ Hlth & Clin Med, SE-90187 Umea, Sweden..
    Rolandsson, Olov
    Umea Univ, Dept Publ Hlth & Clin Med, SE-90187 Umea, Sweden..
    Binge drinking and total alcohol consumption from 16 to 43 years of age are associated with elevated fasting plasma glucose in women: results from the northern Swedish cohort study2017In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 17, 509Article in journal (Refereed)
    Abstract [en]

    Background: Studies have indicated that moderate alcohol consumption is associated with lower incidence of diabetes in women. However, not only the amount but also the drinking pattern could be of importance when assessing the longitudinal relation between alcohol and glucose. Also, there is a lack of studies on alcohol use beginning in adolescence on adult glucose levels. The aim was to examine the association between total alcohol consumption and binge drinking between ages 16 and 43 and fasting plasma glucose at age 43.

    Methods: Data were retrieved from a 27-year prospective cohort study, the Northern Swedish Cohort. In 1981, all 9th grade students (n = 1083) within a municipality in Sweden were invited to participate. There were re-assessments at ages 18, 21, 30 and 43. This particular study sample consisted of 897 participants (82.8%). Fasting plasma glucose (mmol/L) was measured at a health examination at age 43. Total alcohol consumption (in grams) and binge drinking were calculated from alcohol consumption data obtained from questionnaires.

    Results: Descriptive analyses showed that men had higher levels of fasting plasma glucose as compared to women. Men also reported higher levels of alcohol consumption and binge drinking behavior. Linear regressions showed that total alcohol consumption in combination with binge drinking between ages 16 and 43 was associated with elevated fasting plasma glucose at age 43 in women (beta = 0.14, p = 0.003) but not in men after adjustment for BMI, hypertension and smoking at age 43.

    Conclusions: Our findings indicate that reducing binge drinking and alcohol consumption among young and middle-aged women with the highest consumption might be metabolically favorable for their future glucose metabolism.

  • Public defence: 2017-09-08 10:15 Desi, A-huset, Linköping
    Larsson, L. Viktor
    Linköping University, Department of Management and Engineering, Fluid and Mechatronic Systems. Linköping University, Faculty of Science & Engineering.
    Control Aspects of ComplexHydromechanical Transmissions: with a Focus on Displacement Control2017Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis deals with control aspects of complex hydromechanical transmissions. The overall purpose is to increase the knowledge of important aspects to consider during the development of hydromechanical transmissions to ensure transmission functionality. These include ways of evaluating control strategies in early design stages as well as dynamic properties and control aspects of displacement controllers, which are key components in these systems.

    Fuel prices and environmental concerns are factors that drive research on propulsion in heavy construction machinery. Hydromechanical transmissions are strong competitors to conventional torque-converter transmissions used in this application today. They offer high efficiency and wide speed/torque conversion ranges, and may easily be converted to hybrids that allow further fuel savings through energy recuperation. One challenge with hydromechanical transmissions is that they offer many different configurations, which in turn makes it important to enable evaluation of control aspects in early design stages. In this thesis, hardware-in-the-loop simulations, which blend hardware tests and standard software-based simulations, are considered to be a suitable method. A multiple-mode transmission applied to a mid-sized construction machine is modelled and evaluated in offline simulations as well as in hardware-in-the-loopsimulations.

    Hydromechanical transmissions rely on efficient variable pumps/motors with fast, accurate displacement controllers. This thesis studies the dynamic behaviour of the displacement controller in swash-plate axial-piston pumps/motors. A novel control approach in which the displacement is measured with an external sensor is proposed. Performance and limitations of the approach are tested in simulations and in experiments. The experiments showed a significantly improved performance with a controller that is slightly more advanced than a standard proportional controller. The implementation of the controller allows simple tuning and good predictability of the displacement response.

  • Public defence: 2017-09-08 13:15 Sal IV, Universitetshuset, Uppsala
    Larsson, Birgitta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Treatment for childbirth fear with a focus on midwife-led counselling: A national overview, women’s birth preferences and experiences of counselling2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Background: Many women experience childbirth fear to such an extent that it seriously interferes with the woman’s daily life and affects her mental well-being.

    Aim: The overall aim was to conduct an overview of the midwife-led counselling for childbirth fear in Sweden, to investigate women’s birth preferences and to describe their experiences of treatment on childbirth fear, with focus on midwife-led counselling.

    Methods: Study I is a cross-sectional study where 43 out of 45 maternity clinics responded to a questionnaire regarding midwife-led counselling. Study II is a longitudinal survey where 889 women participated of whom 70 received counselling. Data were collected by questionnaires in mid-pregnancy, two months and finally, one year after birth. Study III is a randomised controlled study with 258 participating women assessed with childbirth fear. It compares Internet-based cognitive behaviour therapy (ICBT) with midwife-led counselling. Data were collected by questionnaires twice during pregnancy and two months after birth. Study IV is a qualitative interview study using thematic analysis, including 27 women who received midwife-led counselling during pregnancy.

    Results: Overall, midwife-led counselling was perceived as empowering by the women and increased their confidence when facing birth. The preference for a caesarean section decreased during pregnancy and the majority had a normal vaginal birth but an increase in preference for caesarean section appeared after birth. Half of the women who received treatment for childbirth fear experienced a less than positive birth. Women who had a positive birth experience voiced that the contributing factors were the self-confidence received from counselling and the support from the midwife during birth. Decreased or manageable fear was expressed by the women after counselling and birth, which in turn brought a strengthened confidence for a future pregnancy and birth. Furthermore, major differences exist in counselling for childbirth fear throughout the clinics in Sweden.

    Conclusion: Midwife-led counselling improved women’s confidence toward giving birth and fear was perceived as manageable. Continuous support is crucial to experience birth as positive. Although women’s preferences for caesarean section did not change over time, few women gave birth with a caesarean section without medial reason.  

  • Public defence: 2017-09-15 13:15 K1, Kåkenhus, Norrköping
    Martín-Bylund, Anna
    Linköping University, Department of Social and Welfare Studies, Learning, Aesthetics, Natural science. Linköping University, Faculty of Educational Sciences.
    Towards a minor bilingualism: Exploring variations of language and literacy in early childhood education2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The aim of this compilation thesis is to explore variations in bilingualism with the help of everyday specific situations at a Spanish-Swedish early childhood institution in Sweden, and by means of a ‘material-semiotic theorizing’. This means that material and semiotic elements are treated equally and entwined. Through studying a bilingual preschool practice, theory and politics as three interwoven practices, the thesis produces knowledge on language and literacy as socially and materially divergent, transformative occurrences. The research process is a commitment with Deleuzio-Guattarian philosophy, theory and politics, and is defined as a becoming in and of the three practices (education, theory, politics). Ethical and methodological undertakings are described as results of the interaction of these practices. Processes of data production include a yearlong fieldwork with all year groups (1-5) at a bilingual preschool in Sweden with a Spanish-Swedish language policy. The materials of data (approx. 59 hours of video-recordings and additional field-notes of everyday activities) are extended and developed upon in interaction with theoretical concepts and political concerns in terms of an analytical process that ‘puts theory to work’. The results are phrased as three temporal suggestions: 1) Bilingualism is a plural, collectively produced, both transitory and specific phenomenon 2) Bilingualism emerges with different, simultaneous dimensions of language and literacy (language as both code and material intensities) 3) Bilingualism is shared and public but also private and inconclusive. The thesis also shows the interconnectedness and continuity between different constructions of bilingualism (i.e. separate – flexible, public - private) as well as the productivity of the unknown and of what is labelled as (il)literate expertise. The impact that these suggestions may have in working with bilingualism in early childhood education is discussed. At the same time the discussion inspires to thinking towards a minor bilingualism also in more general terms.

  • Sangfelt, Adrian
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Scandinavian Languages.
    OV-ledföljd och huvudsats-bisatsasymmetri i svenskans historia2017In: Norsk lingvistisk tidsskrift, ISSN 0800-3076, E-ISSN 2387-6719, Vol. 35, no 1, 109-128 p.Article in journal (Refereed)
    Abstract [sv]

    1500-talet är en viktig brytpunkt i den svenska bisatsledföljdens historia. Detta är tiden då den moderna svenska ledföljden med satsadverbial före finit verb slår igenom, men även då objekt i högre grad börjar stå före finita verb. I denna artikel presenteras hypotesen att de två förändringarna har orsakats av samma bakomliggande mekanism, då bägge är avhängiga förlusten av V-till-I-flyttning i svenskans historia. Hypotesen prövas empiriskt genom en undersökning av OV-ledföljd i satser med infinit hjälpverb, en syntaktisk kontext där den predicerar en viss typ av diakront mönster. Den övergripande utvecklingen visar sig också följa prediktionen, även om det troligen finns andra tendenser i svenskans OV-historia som måste förstås och förklaras på ett annat sätt.