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  • Ågren, Mattias
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Slavic Languages.
    Hansen, JulieUppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Slavic Languages. Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Institute for Russian and Eurasian Studies.Nuorluoto, JussiUppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Slavic Languages.Spasenić, JelenaUppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Slavic Languages.
    Slovo. Journal of Slavic Languages, Literatures and Cultures, No. 59, 20182018Collection (editor) (Refereed)
  • Jansson, Olena
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Slavic Languages.
    Maier, Ingrid
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Slavic Languages.
    ”Ruriks stamträd” – en av de ryska skatterna på Carolina Rediviva2018In: Slovo: Journal of Slavic Languages, Literatures and Cultures , ISSN 2001-7395, Vol. 59, p. 7-39Article in journal (Refereed)
    Abstract [en]

    Among the treasures in the university library in Uppsala (Sweden) is an extraordinary genealogical tree of Russia’s Rurikid rulers, beginning with the legendary Rurik and ending with Tsar Fedor Ivanovič, who died in 1598. Up to now it has not been known where it was produced, when it came into being, and who could have been the scribe of the Russian names. In this paper we argue that the genealogical tree was produced in Sweden and that the scribe for the Russian names was Aleksej Mankiev, who helped the Swedish scholar Johan Gabriel Sparwenfeld by producing fair copies of the latter’s manuscripts. Mankiev’s sojourn in Sweden from 1700 to 1718 gives us a first approximation for the date of the drawing. We think that this can be narrowed down to “around 1715”, given the close relationship between the “Uppsala tree” and the Rurikid genealogy presented in Jadro rossijskoj istorii, a manuscript which was finished in Sweden in 1715, most probably also by “our scribe”, Mankiev.

  • Muskala, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Slavic Languages.
    Bibliography for 20172018In: Slovo: Journal of Slavic Languages, Literatures and Cultures , ISSN 2001-7395, Vol. 59, p. 102-107Article in journal (Other academic)
  • Karlsohn, Irina
    Review. Andrea Gullotta. Intellectual Life and Literature at Solovki 1923-1930: The Paris of the Northern Concentration Camps. Cambridge: Legenda 2018. x + 370 pp.2018In: Slovo: Journal of Slavic Languages, Literatures and Cultures , ISSN 2001-7395, Vol. 59, p. 93-94Article in journal (Other academic)
  • Nesset, Tore
    When a single word is enough: Norwegian compounds and their Russian counterparts2018In: Slovo: Journal of Slavic Languages, Literatures and Cultures , ISSN 2001-7395, Vol. 59, p. 61-72Article in journal (Refereed)
    Abstract [en]

    I undertake an empirical analysis of Norwegian compounds with special focus on those that correspond to single words in Russian that are not compounds. Although in many cases the Russian single words have the same meaning as the Norwegian compounds, we frequently encounter semantic shifts of two types, which I refer to as “hyponymy” and “metonymy”. I argue that hyponymy is the default option, but that metonymy is preferred for certain types of compounds, e.g. those where the head represents a part of the non-head (e.g. kirkegolv ‘church floor’) or the head denotes a quantity of the non-head (e.g. melkedråpe ‘drop of milk’). It is furthermore suggested that the choice between hyponymy and metonymy is motivated by the desire to minimize loss of information; while hyponymy normally involves a smaller loss of information, metonymy appears to minimize information loss for certain types of compounds. Finally, I relate my findings to the trade-off between informativeness and economy in language and hypothesize that this trade-off is treated differently in languages like Norwegian, where compounding is a central word-formation mechanism, and Russian, where compounding plays a more modest role in word-formation.

  • Kapustina, Elena
    et al.
    Björklund, Martina
    Лексические средства экспрессивного и эмоционального воздействия в повести Астрид Линдгрен «Эмиль из Лённеберги» и её переводах на русский язык2018In: Slovo: Journal of Slavic Languages, Literatures and Cultures , ISSN 2001-7395, Vol. 59, p. 40-60Article in journal (Refereed)
    Abstract [en]

    Several of Astrid Lindgren’s most famous children’s books exist in two Russian translations: one by Lilianna Lungina and one by Ludmila Braude (often in cooperation with other translators). It is intriguing that Lungina’s translations are generally more popular among readers than those by Braude, even though the latter may seem more true to the original in several respects. In this article we look into the first book of the Emil of Lönneberga series and its two Russian translations (by Lungina and Braude & Paklina), concentrating on the use of emotive vocabulary and words and phrases with expressive and/or emotional connotations. The results of a quantitative analysis show that the utilization of these types of expressions in Braude & Paklina’s translation substantially exceeds their use in Lungina’s translation and the Swedish original text. Lungina’s translation does not essentially differ from the original as to the total number of emotionally loaded expressions, but the relative weight of different types varies. Lungina uses more emotionally loaded and colloquial words and Lindgren more idiomatic expressions and phraseological constructions. In another quantitative analysis we demonstrate how the number of emotionally loaded words is increased in both translations through reduction of repetition, a proposed universal of translation. In a comparative analysis three recurring types of correlation between the original text and its translations are discussed using illustrative examples. Emotionally loaded Swedish words are generally translated with Russian analogues in both translations. However there are instances of utilization of neutral vocabulary in Lungina’s text. Cases of neutralization in both translations are extremely rare. Translation of neutral Swedish words with emotionally loaded or expressive words is far more frequent in Braude & Paklina’s translation than in Lungina’s. The more moderate use of emotive and expressive language makes Lungina’s translation stylistically closer to contemporary readers’ immediate linguistic reality, while Braude & Paklina’s translation might be felt to be stylistically heavy and unnatural.

  • Jansson, Olena
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Slavic Languages.
    News from Uppsala2018In: Slovo: Journal of Slavic Languages, Literatures and Cultures , ISSN 2001-7395, Vol. 59, p. 95-98Article in journal (Other (popular science, discussion, etc.))
  • Åkerman Sarkisian, Karine
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Slavic Languages.
    In memoriam: Professor Andrei Zalizniak2018In: Slovo: Journal of Slavic Languages, Literatures and Cultures , ISSN 2001-7395, Vol. 59, p. 99-101Article in journal (Other (popular science, discussion, etc.))
  • Packalén Parkman, Malgorzata Anna
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Languages, Department of Modern Languages, Slavic Languages.
    I mörkrets skugga… Om Edith Södergrans och Halina Poświatowskas poetiska världar2018In: Slovo: Journal of Slavic Languages, Literatures and Cultures , ISSN 2001-7395, Vol. 59, p. 73-92Article in journal (Refereed)
    Abstract [en]

    Two young women, two extremely talented poets, two distant cultures and one convergent fate marked by living with an incurable illness – this is how one could briefly summarize two of the most fascinating poetic personalities of the 20th century: Edith Södergran and Halina Poświatowska. Both poets died at the age of just over thirty, leaving behind works which testify not only to their great talent and poetic potential, but also to their extraordinary female sensitivity and maturity. Although they came from different cultures and times, and wrote in two different languages (Swedish and Polish), it is hard not to see a stunning affinity between their powerful poetic visions. The article explores these thematic similarities by focusing on their understanding of human fate, female sensuality and desire for existential freedom in expressing their own thoughts and their being in the world.

  • Westbury, Michael, V
    et al.
    Hartmann, Stefanie
    Barlow, Axel
    Wiesel, Ingrid
    Leo, Viyanna
    Welch, Rebecca
    Parker, Daniel M.
    Sicks, Florian
    Ludwig, Arne
    Dalén, Love
    Swedish Museum of Natural History, Department of Bioinformatics and Genetics.
    Hofreiter, Michael
    Extended and Continuous Decline in Effective Population Size Results in Low Genomic Diversity in the World's Rarest Hyena Species, the Brown Hyena2018In: Molecular biology and evolution, ISSN 0737-4038, E-ISSN 1537-1719, Vol. 35, no 5, p. 1225-1237Article in journal (Refereed)
  • van der Valk, Tom
    et al.
    Sandoval-Castellanos, Edson
    Caillaud, Damien
    Ngobobo, Urbain
    Binyinyi, Escobar
    Nishuli, Radar
    Stoinski, Tara
    Gilissen, Emmanuel
    Sonet, Gontran
    Semal, Patrick
    Kalthoff, Daniela C.
    Swedish Museum of Natural History, Department of Zoology.
    Dalén, Love
    Guschanski, Katerina
    Significant loss of mitochondrial diversity within the last century due to extinction of peripheral populations in eastern gorillas2018In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 6551Article in journal (Refereed)
  • Eskeröd, Albert
    The Nordic Museum.
    Knävlingar från Branteviks fiskeläge i Skåne1950In: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1950, p. 75-90Chapter in book (Other academic)
  • Rehnberg, Mats
    The Nordic Museum.
    Bröllopsföljet från Telemarken1950In: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1950, p. 65-74Chapter in book (Other academic)
  • Gross, Elisabeth
    et al.
    Stockholm Univ, Dept Phys Geog, SE-10691 Stockholm, Sweden;Biol Anstalt Helgoland, Helmholtz Zentrum Polar & Meeresforsch, Alfred Wegener Inst, Helgoland, Germany.
    Mård, Johanna
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL. Centre of Natural Hazards and Disaster Science, Uppsala University.
    Kalantari, Zahra
    Stockholm Univ, Dept Phys Geog, SE-10691 Stockholm, Sweden;Stockholm Univ, Bolin Ctr Climate Res, Stockholm, Sweden.
    Bring, Arvid
    Stockholm Univ, Dept Phys Geog, SE-10691 Stockholm, Sweden;Stockholm Univ, Bolin Ctr Climate Res, Stockholm, Sweden.
    Links between Nordic and Arctic hydroclimate and vegetation changes: Contribution to possible landscape-scale nature-based solutions2018In: Land Degradation and Development, ISSN 1085-3278, E-ISSN 1099-145X, Vol. 29, no 10, p. 3663-3673Article in journal (Refereed)
    Abstract [en]

    In Nordic and Arctic regions, the rapidly warming climate sustains hydroclimatic and vegetation changes in the landscape. There is evidence for an increase in vegetation density in some regions, a trend that is expected as a response to increasing temperature and precipitation. If the hydroclimatic changes are linked to vegetation response, it could be viewed as a landscape-scale nature-based solution (NBS) that could moderate the runoff response, as denser vegetation should lead to increased evapotranspiration and lower runoff. In this paper, we investigate and compare hydroclimatic changes over a set of basins in the Nordic region and northwest America and compare with changes in vegetation density, analyzed using the normalized difference vegetation index (NDVI) for three time periods: 1973-1978, 1993-1998, and 2013-2016. Over the period of the 1970s to 1990s, the hydroclimate became warmer and wetter and vegetation density increased, but over a later period from the 1990s to 2010s, vegetation density decreased, despite a continuing warming and wetting of the climate. Although there was a tendency for runoff to decrease in basins where vegetation density increased, the relation between precipitation and runoff was much stronger. Overall, we found weak evidence for vegetation density changes, driven by hydroclimate, to act as NBS on the landscape scale over the studied regions. However, as hydroclimatic changes interact with vegetation changes and their ensuing hydrological responses in complex ways, more detailed investigations are needed to determine the potential NBS effect on the landscape scale across Nordic and Arctic regions.

  • Public defence: 2019-01-18 09:15 Room B21, Uppsala
    Jiang, Wangshu
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Biology.
    Of spiders, bugs, and men: Structural and functional studies of proteins involved in assembly2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Protein assembly enables complex machineries while being economical with genetic information. However, protein assembly also constitutes a potential threat to the host, and needs to be carefully regulated.

    Sulfate is a common source of sulfur for cysteine synthesis in bacteria. A putative sulfate permease CysZ from Escherichia coli appears much larger than its apparent molecular mass when analyzed by chromatography and native gel. Clearly CysZ undergoes homo-oligomerization. Using isothermal titration calorimetry, we confirmed that CysZ binds to its putative substrate sulfate, and also sulfite with higher affinity. CysZ-mediated sulfate transport—in both E. coli whole cells and proteoliposomes—was inhibited in the presence of sulfite, indicating a feedback inhibition mechanism.

    Proteus mirabilis is a Gram-negative bacterium causing urinary tract infections. Its simultaneous expression of multiple fimbriae enables colonization and biofilm formation. Fimbriae are surface appendages assembled from protein subunits, with distal adhesins specifically recognizing host-cell receptors. We present the first three structures of P. mirabilis fimbrial adhesins. While UcaD and AtfE adopt the canonical immunoglobulin-like fold, MrpH has a previously unknown fold. The coordination of Zn or Cu ion by three conserved histidine residues in MrpH is required for MrpH-dependent biofilm formation.

    Spider silk is an assembly of large proteins called spidroins. The N-terminal domain (NT) of spidroins senses the pH decrease along the silk spinning gland, and transits from monomer to dimer. A locked NT dimer interlinks spidroin molecules into polymers. We identified a new asymmetric dimer form of NT by x-ray crystallography. With additional evidence from small angle x-ray scattering (SAXS), we propose the asymmetric dimer as a common intermediate of NT in silk formation.

    Alzheimer’s disease is a life-threatening dementia, where aggregation-prone Aβ peptides self-assemble into amyloid fibrils. Bri2 BRICHOS is a molecular chaperone that efficiently delays Aβ fibrillation, and protects the region of its pro-protein with high β-propensity from aggregation. Combining SAXS and microscale thermophoresis data, we confirmed binding between Bri2 BRICHOS and its native client peptide. Using site-directed mutagenesis, we showed that three conserved tyrosine residues in Bri2 BRICHOS are important for its anti-Aβ fibrillation activity.

  • Public defence: 2019-01-11 13:00 B41, Uppsala
    Söderholm, Annika
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Biology.
    The Importance of Being Promiscuous: Understanding enzyme function, specificity, and evolution through structure2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Enzymes are known to be amazingly specific and efficient catalysts. However, many enzymes also have so-called promiscuous functions, i.e., they are able to catalyze other reactions than their main one. The promiscuous activities are often low, serendipitous, and under neutral selection but if conditions arise that make them beneficial, they can play an important role in the evolution of new enzymes. In this thesis, I present three studies where we have characterized different enzyme families by structural and biochemical methods. The studies demonstrate the occurrence of enzyme promiscuity and its potential role in evolution and organismal adaptation.

    In the first study, I describe the characterization of wild type and mutant HisA enzymes from Salmonella enterica. In the first part of this study, we could clarify the mechanistic cycle of HisA by solving crystal structures that showed different conformations of wild type HisA in complex with its labile substrate ProFAR (N´-[(5´-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide). In the second part of this study, structures of mutant enzymes from a real-time evolution study provided us with an atomic-level description of how HisA had evolved a new function. The HisA mutants had acquired TrpF activity, either in addition to (bifunctional generalists) or instead of (TrpF specialists) their HisA activity. In the second study, I present the crystal structure and demonstrate promiscuous activity of the TrpC enzyme from Pseudomonas aeruginosa. The activity data demonstrates that the enzyme can turn over a substrate that lacks a substituent that was previously considered essential for catalysis. In the third study, I present the structural and functional characterization of SAM (S-Adenosyl methionine) hydrolases from bacteriophages. These enzymes were discovered because of their ability to rescue auxotrophic bacteria by inducing expression of a promiscuous bacterial enzyme.  

  • Shirey, Ryan J.
    et al.
    Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA;Scripps Res Inst, Skaggs Inst Chem Biol, Worm Inst Res & Med, Dept Immunol, 10550 North Torrey, La Jolla, CA 92037 USA.
    Globisch, Daniel
    Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA;Scripps Res Inst, Skaggs Inst Chem Biol, Worm Inst Res & Med, Dept Immunol, 10550 North Torrey, La Jolla, CA 92037 USA.
    Eubanks, Lisa M.
    Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA;Scripps Res Inst, Skaggs Inst Chem Biol, Worm Inst Res & Med, Dept Immunol, 10550 North Torrey, La Jolla, CA 92037 USA.
    Hixon, Mark S.
    Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA;Scripps Res Inst, Skaggs Inst Chem Biol, Worm Inst Res & Med, Dept Immunol, 10550 North Torrey, La Jolla, CA 92037 USA.
    Janda, Kim D.
    Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA;Scripps Res Inst, Skaggs Inst Chem Biol, Worm Inst Res & Med, Dept Immunol, 10550 North Torrey, La Jolla, CA 92037 USA.
    Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis2018In: ACS INFECTIOUS DISEASES, ISSN 2373-8227, Vol. 4, no 10, p. 1423-1431Article in journal (Refereed)
    Abstract [en]

    The parasitic disease onchocerciasis is the second leading cause of preventable blindness, afflicting more than 18 million people worldwide. Despite an available treatment, ivermectin, and control efforts by the World Health Organization, onchocerciasis remains a burden in many regions. With an estimated 120 million people living in areas at risk of infection, efforts are now shifting from prevention to surveillance and elimination. The lack of a robust, point-of-care diagnostic for an active Onchocerca infection has been a limiting factor in these efforts. Previously, we reported the discovery of the biomarker N-acetyl-tyramine-O-glucuronide (NATOG) in human urine samples and its ability to track treatment progression between medicated patients relative to placebo; we also established its capability to monitor disease burden in a jird model. NATOG is a human-produced metabolite of tyramine, which itself is produced as a nematode neurotransmitter. The ability of NATOG to distinguish between active and past infection overcomes the limitations of antibody biomarkers and PCR methodologies. Lateral flow immunoassay (LFIA) diagnostics offer the versatility and simplicity to be employed in the field and are inexpensive enough to be utilized in large-scale screening efforts. Herein, we report the development and assessment of a NATOG-based urine LFIA for onchocerciasis, which accurately identified 85% of analyzed patient samples (N = 27).

  • Hammarström, Rolf
    et al.
    Försth, Michael
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Fire Research.
    Brandrisker i transformatoreroch reläverksamhet medsupport2008Report (Other academic)
    Abstract [sv]

    Vid en brand, eller incident som kan leda till brand, ger en tidig upptäckt och omedelbar åtgärd en minimerad skadebild. De flesta ställverk är obemannade. Det förekommer underhållsverksamhet under begränsad tid men till största delen har ställverken ingen personal på plats. Många anläggningar ligger också långt från tätbebyggt område vilket medför långa insatstider för räddningstjänsten och ansvarig personal. Vår utgångspunkt är därför att föreslå åtgärder som ger minsta möjliga stilleståndstid vid brand eller incidenter som kan leda till brand. Det är också viktigt att kunna övervaka och styra skeenden på distans. Resultatet av denna studie kan sammanfattas i följande rekommendationer. 1. Möjliggör tidig upptäckt med hjälp av högklassig detektionsutrustning. 2. Möjlighet att omedelbart identifiera problemet, från bemannad station, exempelvis via fjärrkamera. 3. Möjlighet att koppla bort problemområdet från kraftkällan efter identifierad incident. 4. Det bör finnas släcksystem som aktiveras automatiskt via detektion eller manuellt (fjärrutlösning). 5. Man bör använda släckmedel för relärum som inte skadar elektronikprodukter. 6. Täta genomföringar för att förhindra brandspridning och skadlig påverkan av brandgaser i angränsande rum. 7. Man bör utveckla släcksystem för transformatorer som kan aktiveras innan brand utbryter. 8. Möjliggöra access även i strömlöst tillstånd 9. Särskilja redundanta system 10. Viss överkapacitet på transformatorn

    Det har visat sig mycket svårt att få en tydlig bild av förekomsten av bränder eftersom de tillfrågade parterna, typiskt kraftbolag, endera inte har någon tillfredställande dokumentation över tillbud, eller har som policy att inte lämna ut den typen av uppgifter. Förbättrade rutiner för dokumentation av tillbud är en förutsättning för en långsiktig förbättring av brandskyddet. Kunskapen om bränder och explosioner i transformatorer är mycket mer begränsad än bränder i byggnader och liknande. Därför behövs ytterligare studier av de mekanismer som föregår och orsakar en transformatorexplosion. Vi föreslår ett antal forskningsprojekt i syfte att kartlägga dessa mekanismer. I förlängningen kan detta resultera i system som förhindrar eller begränsar konsekvenserna av det som idag leder till att transformatorer exploderar.

  • Gehandler, Jonatan
    et al.
    RISE - Research Institutes of Sweden, Safety and Transport, Safety.
    Ingason, Haukur
    RISE - Research Institutes of Sweden, Safety and Transport, Safety.
    Principer och strategier för ventilation vid brand i undermarksanläggningar2018Report (Other academic)
    Abstract [en]

    The report describes different underground systems including mines and tunnels during construction (tunneling). The key factors that affect fire development in underground systems are described. Proposal and recommendations for ventilation strategies in case of fire are given. The report covers both fuel- and ventilation-controlled fires. In general, a minimal ventilation limits the fire growth and may even inert the fire through ascended smoke. A minimal ventilation also contributes to improved conditions for a first fire extinguishing attempt and evacuation.

  • Li, Ying Zhen
    et al.
    RISE - Research Institutes of Sweden, Safety and Transport, Safety.
    Ingason, Haukur
    RISE - Research Institutes of Sweden, Safety and Transport, Safety.
    Jiang, Lei
    RISE - Research Institutes of Sweden, Safety and Transport, Safety.
    Influence of tunnel slope on smoke control2018Report (Other academic)
    Abstract [en]

    The critical velocity and backlayering length in sloped tunnels are investigated by numerical simulations using FDS. Simulation in two full-scale tunnels, with negative slopes ranging up to -18 % and heat release rates from 5 to 100 MW were carried out.

    The results show that NFPA 502 equation significantly overestimates the effect of negative slopes.

    The equation proposed by Atkinson and Wu is found to be in closer agreement with the results. A simplified correlation, i.e. Eq. (12), is proposed and recommended for practical use.

    The previous correlation for dimensionless backlayering length, Eq. (3), is valid for tunnels of various slopes and aspect ratios, and can be used for prediction of backlayering length.

  • Samuelsson, Oscar
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control. IVL Swedish Environm Res Inst, Stockholm, Sweden.
    Bjork, Anders
    IVL Swedish Environm Res Inst, Stockholm, Sweden.
    Zambrano, Jesus
    Malardalens Hgsk, Vasteras, Sweden.
    Carlsson, Bengt
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Automatic control. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Systems and Control. Uppsala Univ, Uppsala, Sweden.
    Fault signatures and bias progression in dissolved oxygen sensors2018In: Water Science and Technology, ISSN 0273-1223, E-ISSN 1996-9732, Vol. 78, no 5, p. 1034-1044Article in journal (Refereed)
    Abstract [en]

    Biofilm fouling is known to impact the data quality of sensors, but little is known about the exact effects. We studied the effects of artificial and real biofilm fouling on dissolved oxygen (DO) sensors in full-scale water resource recovery facilities, and how this can automatically be detected. Biofilm fouling resulted in different drift direction and bias magnitudes for optical (OPT) and electrochemical (MEC) DO sensors. The OPT-sensor was more affected by biofilm fouling compared to the MEC-sensor, especially during summer conditions. A bias of 1 mg/L was detected by analysing the impulse response (IR) of the automatic air cleaning system in the DO sensor. The IR is an effect of a temporal increase in DO concentration during the automatic air cleaning. The IRs received distinct pattern changes that were matched with faults including: biofilm fouling, disturbances in the air supply to the cleaning system, and damaged sensor membrane, which can be used for fault diagnosis. The results highlight the importance of a condition-based sensor maintenance schedule in contrast to fixed cleaning intervals. Further, the results stress the importance of understanding and detecting bias due to biofilm fouling, in order to maintain a robust and resource-efficient process control.

  • Markasz, Laszlo
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Perinatal, Neonatal and Pediatric Cardiology Research.
    Wanders, Alkwin
    Umea Univ, Dept Biomed Sci, Umea, Sweden.
    Szekely, Laszlo
    Karolinska Inst, Dept Lab Med, Div Pathol, Stockholm, Sweden.
    Engstrand Lilja, Helene
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Pediatric Surgery.
    Diminished DEFA6 Expression in Paneth Cells Is Associated with Necrotizing Enterocolitis2018In: Gastroenterology Research and Practice, ISSN 1687-6121, E-ISSN 1687-630X, article id 7345426Article in journal (Refereed)
    Abstract [en]

    Background. Necrotizing enterocolitis (NEC) is the most common gastrointestinal disorder in premature infants with a high morbidity and mortality. Paneth cell dysfunction has been suggested to be involved in the pathogenesis of NEC. Defensin alpha-6 (DEFA6) is a specific marker for Paneth cells acting as part of the innate immunity in the human intestines. The aim of this study was to investigate the expression of DEFA6 in infants with NEC. Materials and Methods. Infants who underwent bowel resection for NEC at level III NICU in Sweden between August 2004 and September 2013 were eligible for the study. Macroscopically vital tissues were selected for histopathological evaluation. All infants in the control group underwent laparotomy and had ileostomy due to dysmotility, and samples were taken from the site of the stoma. DEFA6 expression was studied by immunohistochemistry. Digital image analysis was used for an objective and precise description of the samples. Results. A total of 12 infants were included in the study, eight with NEC and four controls. The tissue samples were taken from the colon (n = 1), jejunum (n = 1), and ileum (n = 10). Both the NEC and control groups consisted of extremely premature and term infants (control group: 25-40 gestational weeks, NEC group: 23-39 gestational weeks). The postnatal age at the time of surgery varied in both groups (control group: 4-47 days, NEC group: 4-50 days). DEFA6 expression in the NEC group was significantly lower than that in the control group and did not correlate with gestational age. Conclusion. The diminished DEFA6 expression in Paneth cells associated with NEC in this study supports the hypothesis that alpha-defensins are involved in the pathophysiology of NEC. Future studies are needed to elucidate the role of alpha-defensins in NEC aiming at finding preventive and therapeutic strategies against NEC.

  • Asan, Noor Badariah
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Hassan, Emadeldeen
    Umea Univ, Dept Comp Sci, S-90187 Umea, Sweden;Menoufia Univ, Dept Elect & Elect Commun, Menoufia 32952, Egypt.
    Velander, Jacob
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Redzwan, Syaiful
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Noreland, Daniel
    Umea Univ, Dept Comp Sci, S-90187 Umea, Sweden.
    Blokhuis, Taco J.
    Maastricht Univ, Med Ctr, Dept Surg, NL-6229 HX Maastricht, Netherlands.
    Wadbro, Eddie
    Umea Univ, Dept Comp Sci, S-90187 Umea, Sweden.
    Berggren, Martin
    Umea Univ, Dept Comp Sci, S-90187 Umea, Sweden.
    Voigt, Thiemo
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Architecture and Computer Communication.
    Augustine, Robin
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Characterization of the Fat Channel for Intra-Body Communication at R-Band Frequencies2018In: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 18, no 9, article id 2752Article in journal (Refereed)
    Abstract [en]

    In this paper, we investigate the use of fat tissue as a communication channel between in-body, implanted devices at R-band frequencies (1.7-2.6 GHz). The proposed fat channel is based on an anatomical model of the human body. We propose a novel probe that is optimized to efficiently radiate the R-band frequencies into the fat tissue. We use our probe to evaluate the path loss of the fat channel by studying the channel transmission coefficient over the R-band frequencies. We conduct extensive simulation studies and validate our results by experimentation on phantom and ex-vivo porcine tissue, with good agreement between simulations and experiments. We demonstrate a performance comparison between the fat channel and similar waveguide structures. Our characterization of the fat channel reveals propagation path loss of similar to 0.7 dB and similar to 1.9 dB per cm for phantom and ex-vivo porcine tissue, respectively. These results demonstrate that fat tissue can be used as a communication channel for high data rate intra-body networks.

  • Elinder, Mikael
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics. Res Inst Ind Econ IFN, Stockholm, Sweden.
    Erixson, Oscar
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics.
    Waldenstrom, Daniel
    Res Inst Ind Econ IFN, Stockholm, Sweden; IZA, CEPR, Paris Sch Econ, Paris, France.
    Inheritance and wealth inequality: Evidence from population registers2018In: Journal of Public Economics, ISSN 0047-2727, E-ISSN 1879-2316, Vol. 165, p. 17-30Article in journal (Refereed)
    Abstract [en]

    This paper uses population register data on inheritances and wealth in Sweden to estimate the causal impact of inheritances on wealth inequality. We find that inheritances reduce wealth inequality, as measured by the Gini coefficient or top wealth shares, but that they increase absolute dispersion. This duality in effects stems from the fact that even though richer heirs inherit larger amounts, the relative importance of the inheritance is larger for less wealthy heirs, who inherit more relative to their pre-inheritance wealth. This is in part driven by the fact that heirs do not inherit debts, which makes the distribution of inheritances more equal than the distribution of wealth among the heirs. Behavioral adjustments seem to mitigate the equalizing effect of inheritances, possibly through higher consumption among the poorer heirs. Inheritance taxation counteracts the equalizing inheritance effect, but redistribution of inheritance tax revenues can reverse this result and make the inheritance tax equalizing. Finally, we also find that inheritances increase intragenerational wealth mobility, but the effect is short-lived.

  • Murugesu, Suganya
    et al.
    Kulliyyah Pharm Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Kuantan 25200, Pahang Darul Ma, Malaysia.
    Ibrahim, Zalikha
    Kulliyyah Pharm Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Kuantan 25200, Pahang Darul Ma, Malaysia.
    Ahmed, Qamar-Uddin
    Kulliyyah Pharm Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Kuantan 25200, Pahang Darul Ma, Malaysia.
    Yusoff, Nik-Idris Nik
    Kulliyyah Pharm Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Kuantan 25200, Pahang Darul Ma, Malaysia.
    Uzir, Bisha-Fathamah
    Kulliyyah Pharm Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Kuantan 25200, Pahang Darul Ma, Malaysia.
    Perumal, Vikneswari
    Univ Kuala Lumpur, Royal Coll Med Perak, Fac Pharm & Hlth Sci, Ipoh 30450, Perak Darul Rid, Malaysia.
    Abas, Faridah
    Univ Putra Malaysia, Lab Nat Prod, Inst Biosci, Serdang 43300, Selangor Darul, Malaysia.
    Saari, Khozirah
    Univ Putra Malaysia, Lab Nat Prod, Inst Biosci, Serdang 43300, Selangor Darul, Malaysia.
    El-Seedi, Hesham
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi. Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan.
    Khatib, Alfi
    Kulliyyah Pharm Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Kuantan 25200, Pahang Darul Ma, Malaysia;Univ Putra Malaysia, Lab Nat Prod, Inst Biosci, Serdang 43300, Selangor Darul, Malaysia.
    Characterization of alpha-Glucosidase Inhibitors from Clinacanthus nutans Lindau Leaves by Gas Chromatography-Mass Spectrometry-Based Metabolomics and Molecular Docking Simulation2018In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 23, no 9, article id 2402Article in journal (Refereed)
    Abstract [en]

    Background: Clinacanthus nutans (C. nutans) is an Acanthaceae herbal shrub traditionally consumed to treat various diseases including diabetes in Malaysia. This study was designed to evaluate the alpha-glucosidase inhibitory activity of C. nutans leaves extracts, and to identify the metabolites responsible for the bioactivity. Methods: Crude extract obtained from the dried leaves using 80% methanolic solution was further partitioned using different polarity solvents. The resultant extracts were investigated for their alpha-glucosidase inhibitory potential followed by metabolites profiling using the gas chromatography tandem with mass spectrometry (GC-MS). Results: Multivariate data analysis was developed by correlating the bioactivity, and GC-MS data generated a suitable partial least square (PLS) model resulting in 11 bioactive compounds, namely, palmitic acid, phytol, hexadecanoic acid (methyl ester), 1-monopalmitin, stigmast-5-ene, pentadecanoic acid, heptadecanoic acid, 1-linolenoylglycerol, glycerol monostearate, alpha-tocospiro B, and stigmasterol. In-silico study via molecular docking was carried out using the crystal structure Saccharomyces cerevisiae isomaltase (PDB code: 3A4A). Interactions between the inhibitors and the protein were predicted involving residues, namely LYS156, THR310, PRO312, LEU313, GLU411, and ASN415 with hydrogen bond, while PHE314 and ARG315 with hydrophobic bonding. Conclusion: The study provides informative data on the potential alpha-glucosidase inhibitors identified in C. nutans leaves, indicating the plant's therapeutic effect to manage hyperglycemia.

  • Andrén, Erik
    The Nordic Museum.
    Stadsbyggmästarens barocktak1950In: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1950, p. 57-64Chapter in book (Other academic)
  • Kerpershoek, Liselot
    et al.
    Maastricht Univ, Alzheimer Ctr Limburg, Maastricht, Netherlands.
    de Vugt, Marjolein
    Maastricht Univ, Alzheimer Ctr Limburg, Maastricht, Netherlands.
    Wolfs, Claire
    Maastricht Univ, Alzheimer Ctr Limburg, Maastricht, Netherlands.
    Woods, Bob
    Bangor Univ, Bangor, Gwynedd, Wales.
    Jelley, Hannah
    Bangor Univ, Bangor, Gwynedd, Wales.
    Orrell, Martin
    Bangor Univ, Bangor, Gwynedd, Wales.
    Stephan, Astrid
    Martin Luther Univ Halle Wittenberg DE, Inst Hlth & Nursing Sci, Halle, Germany.
    Bieber, Anja
    Martin Luther Univ Halle Wittenberg DE, Inst Hlth & Nursing Sci, Halle, Germany.
    Meyer, Gabriele
    Martin Luther Univ Halle Wittenberg DE, Inst Hlth & Nursing Sci, Halle, Germany.
    Selbaek, Geir
    Oslo Univ Hosp, Dept Geriatr Med, Oslo, Norway.
    Handels, Ron
    Maastricht Univ, Alzheimer Ctr Limburg, Maastricht, Netherlands;Karolinska Inst, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
    Wimo, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Karolinska Inst, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
    Hopper, Louise
    Dublin City Univ, Sch Nursing & Human Sci, Dublin, Ireland.
    Irving, Kate
    Dublin City Univ, Sch Nursing & Human Sci, Dublin, Ireland.
    Marques, Maria
    Univ Nova Lisboa, Nova Med Sch, CEDOC, Fac Ciencias Med, Lisbon, Portugal.
    Goncalves-Pereira, Manuel
    Univ Nova Lisboa, Nova Med Sch, CEDOC, Fac Ciencias Med, Lisbon, Portugal.
    Portolani, Elisa
    IRCCS Ctr S Giovanni di Dio, Memory Clin, Alzheimers Res Unit, Milan, Italy.
    Zanetti, Orazio
    IRCCS Ctr S Giovanni di Dio, Memory Clin, Alzheimers Res Unit, Milan, Italy.
    Verhey, Frans
    Maastricht Univ, Alzheimer Ctr Limburg, Maastricht, Netherlands.
    Needs and quality of life of people with middle-stage dementia and their family carers from the European Actifcare study. When informal care alone may not suffice2018In: Aging & Mental Health, ISSN 1360-7863, E-ISSN 1364-6915, Vol. 22, no 7, p. 897-902Article in journal (Refereed)
    Abstract [en]

    Objective: The Actifcare (Access to timely formal care) study investigated needs of people with dementia and their families during the phase in which formal care is being considered, and examined whether higher need levels are related to lower quality of life (QOL).Method: From eight European countries 451 people with dementia and their carers participated. Needs were measured with the Camberwell Assessment of Need for the Elderly. QOL was measured with the QOL-AD, and carer quality of life was measured with the CarerQol. The relationship between needs and QOL was analysed with multiple regression analyses.Results: Needs were expressed in the domains of psychological distress, daytime activities, company and information. People with dementia rated their unmet needs significantly lower than their carers: the mean number of self-rated unmet needs was 0.95, whereas the mean proxy ratings were 1.66. For met needs, the self-rated mean was 5.5 and was 8 when proxy-rated. The level of needs reported was negatively associated with QOL for both.Conclusion: The study results show that informal carers reported almost twice as many needs as people with dementia. The domains in which needs are expressed should be the primary focus for interventions to support QOL.The perspectives of people with dementia are informative when identifying needs.

  • Ngoc, Trinh Minh
    et al.
    Duy, Nguyen Van
    Hung, Chu Manh
    Hoa, Nguyen Duc
    Trung, Nguyen Ngoc
    Nguyen, Hugo
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Hieu, Nguyen Van
    Ultralow power consumption gas sensor based on a self- heated nanojunction of SnO2 nanowires+2018In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 8, no 63, p. 36323-36330Article in journal (Refereed)
    Abstract [en]

    The long duration of a working device with a limited battery capacity requires gas sensors with low power consumption. A self-heated gas sensor is a highly promising candidate to satisfy this requirement. In this study, two gas sensors with sparse and dense SnO2 nanowire (NW) networks were investigated under the Joule heating effect at the nanojunction. Results showed that the local heating nanojunction was effective for NO2 sensing but generally not for reduction gases. At 1 W, the sparse NW sensor showed a good sensing performance to the NO2 gas. The dense SnO2 NW network required a high-power supply for gas-sensitive activation, but was suitable for reduction gases. A power of approximately 500 W was also needed for a fast recovery time. Notably, the dense NW sensor can response to ethanol and H2S gases. Results also showed that the self-heated sensors were simple in design and reproducible in terms of the fabrication process.

  • Nilsing Strid, Emma
    Linköping University, Linköping, Sweden.
    The Sick Leave Process: Sick Leave Guidelines, Sickness Certificates, and Experiences of Professionals2013Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Decisions on entitlement to sickness benefits and return to work interventions have substantial impact on individuals’ lives and on society. In most Western European countries, such decisions are based on sickness certificates, which should provide information on how a disease or injury reduces the individual’s work ability. These are challenging and complex assessments. In 2008, guidelines for the management of sick leave were implemented in Sweden, emphasizing early assessments of work ability and return to work, and increasing the quality demands of sickness certificates by underscoring descriptions of activity limitations related to work. The overall aim of this thesis was to gain a deeper knowledge of the sick leave process with special emphasis on the content of sickness certificates and primary health care (PHC) professionals’ experiences with the process. Specific aims were to compare the quality of sickness certificates regarding descriptions of functioning by the use of WHO’s International Classification of Functioning, disability, and health (ICF), as well as the prescribed interventions before versus after implementation of the Swedish sick leave guidelines.

    The thesis comprises three studies. A cross-sectional design was used in studies I and II, which included 475 and 501 new sickness certificates consecutively collected in Östergötland County, Sweden, in 2007 and 2009, respectively. Text on functioning was analysed with a deductive content analysis using the ICF. Study III was an exploratory study using data from four semi-structured focus group discussions with a purposeful sample of PHC professionals (n=18) in Östergötland County. An inductive content analysis was used in this study.

    The thesis comprises three studies. A cross-sectional design was used in studies I and II, which included 475 and 501 new sickness certificates consecutively collected in Östergötland County, Sweden, in 2007 and 2009, respectively. Text on functioning was analysed with a deductive content analysis using the ICF. Study III was an exploratory study using data from four semi-structured focus group discussions with a purposeful sample of PHC professionals (n=18) in Östergötland County. An inductive content analysis was used in this study.

    An overall conclusion drawn from this thesis is that patient functioning and needs might not be adequately communicated in the sick leave process. Despite the implementation of sick leave guidelines, this information is limited in sickness certificates and the collaboration is poor among the involved stakeholders, i.e., health care, the social insurance office, the employer and the OHS. The basis for decisions on entitlement to sickness benefits could be improved by including a description of the patients’ activity limitations or participation restrictions related to work demands. One way to enhance the decision basis might be to use the available team competencies at the PHC.

  • Selling, Gösta
    The Nordic Museum.
    Paradsängkammaren från Ulvsunda1950In: Fataburen: Nordiska museet och Skansens årsbok, Stockholm: Nordiska museets förlag, 1950, p. 43-54Chapter in book (Other academic)
  • Lindgren, Charlotte
    et al.
    Dalarna University, School of Humanities and Media Studies, French.
    Wingstedt, Johnny
    Dalarna University, School of Humanities and Media Studies, Sound and Music Production.
    Johansson, Sören
    Dalarna University, School of Humanities and Media Studies, Sound and Music Production.
    Röstljud i onlinekurser: Charlotte Lindgren samtalar med Johnny Wingstedt om NGL-projektet som handlar om röstljudets estetiska potential i lärandesituationer online.2018Other (Other (popular science, discussion, etc.))
  • Liedgren, Rut
    The Nordic Museum.
    Sailor's gifts1950In: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1950, p. 25-42Chapter in book (Other academic)
  • Wietmarschen, Herman
    et al.
    Louis Bolk Institute, Bunnik, Netherlands.
    Tjaden, Bram
    Trainer, Aandachtigedokters, Zeist, Netherlands.
    van Vliet, Marja
    Louis Bolk Institute, Bunnik, The Netherlands.
    Battjes-Fries, Marieke
    Louis Bolk Institute, Bunnik, The Netherlands.
    Jong, Miek C.
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences. Louis Bolk Institute, Bunnik, The Netherlands.
    Effects of mindfulness training on perceived stress, self-compassion, and self-reflection of primary care physicians: a mixed-methods study2018In: British Journal of General Practice, ISSN 0960-1643, E-ISSN 1478-5242, , p. 11Article in journal (Refereed)
    Abstract [en]

    Background Primary care physicians are subjected to a high workload, which can lead to stress and a high incidence of burnout. A mindfulness training course was developed and implemented for primary care physicians to better cope with stress and improve job functioning.

    Aim To gain insight into the effects of the mindfulness training on perceived stress, self-compassion, and self-reflection of primary care physicians.

    Design & setting A pragmatic mixed-methods pre–post design in which physicians received 8 weeks of mindfulness training.

    Method Participants completed validated questionnaires on perceived stress (Perceived Stress Scale [PSS]), self-compassion (Self-Compassion Scale [SCS]), and self-reflection (Groningen Reflection Ability Scale [GRAS]) before the training, directly after, and 6 months later. Semi-structured interviews were conducted with six participants after the training and a content analysis was performed to gain in depth understanding of experiences.

    Results A total of 54 physicians participated in the study. PSS was reduced (mean difference [MD] -4.5, P<0.001), SCS improved (MD = 0.5, P<0.001), and GRAS improved (MD = 3.3, P<0.001), directly after the 8-week training compared with before training. Six months later, PSS was still reduced (MD = -2.9, P = 0.025) and SCS improved (MD = 0.7, P<0.001). GRAS did not remain significant (MD = 2.5, P = 0.120). Qualitative analysis revealed four themes: being more aware of their own feelings and thoughts; being better able to accept situations; experiencing more peacefulness; and having more openness to the self and others.

    Conclusion Mindfulness training might be an effective approach for improving stress resilience, self-compassion, and self-reflection in primary care physicians.

  • Valan, Lotha
    et al.
    Mid Sweden University, Faculty of Human Sciences, Department of Nursing Sciences. Region Västernorrland.
    Kristiansen, Lisbeth
    Högskolan i Gävle.
    Sundin, Karin
    Umeå Universitet.
    Jong, Mats
    Mid Sweden University, Faculty of Human Sciences, Department of Nursing Sciences.
    Health-Related Internet Information Both Strengthens and Weakens Parents’ Potential for Self-Care: A Mixed-Methods Study on Parents’ Search Patterns2018In: Open Journal of Nursing, ISSN 2162-5336, E-ISSN 2162-5344, Vol. 8, no 10, p. 731-745, article id 88148Article in journal (Refereed)
    Abstract [en]

    Today’s parents belong to the digital generation and regularly use the Internet as a source of information. Parents’ quests for health-related online information comprise an effort to manage symptoms of illness or address questions about child development which may be an expression of self-management or self-care. Purpose: This study aims to describe health and child development related Internet search patterns used by parents of children ages zero to six, and further, how the obtained information was used in contacts with Child Health Care. Design and Methods: A two-step mixed- method approach is used in this study, comprising both a quantitative and a qualitative approach. First, a questionnaire was distributed to parents (n = 800) at 13 health centers in a medium sized county in Sweden. Second, one narrative interview with two parents total was conducted. Descriptive and non-parametric statistics were calculated, and qualitative manifest content analyses were performed. Results: A total of 687 completed the questionnaire, which corresponds to a response rate of 86%. The results show that 97% used the Internet for health-related and developmental child issues. The results show that parents often look at basic tips and the Internet is seen as a fast and accessible forum to obtain information. Parents often initiated their Internet searches using Google search for the specific subject, but the most common and most used website (used by 95% of parents), was the Swedish health site 1177.se. 98.4% of parents evaluated the general information searches they made on the Internet as reliable despite only 31% of the parents checking to see if the websites they used were scientifically based. Parents (81.7%) stated that they wanted their Child Health Nurses (CHN) to give them recommendations for valid websites. Conclusions: The results in this study show that, on the one hand, the Internet could strengthen parental knowledge (support self-care capacity), but, on the other hand, the found information could worry them and increase their anxiety—negatively affected self-care capacity. The parents suggested that the information should be double-checked to establish trust and develop self-care knowledge. Having a good resource to rely on, such as personal contact with a CHN, or using reliable websites seems to strengthen and reassure parents.

  • Deng, Pan
    et al.
    Huazhong Univ Sci & Technol, State Key Lab Digital Mfg Equipment & Technol, Wuhan, Hubei, Peoples R China.
    Fu, Cheng-Jie
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
    Wu, Zhigang
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. Huazhong Univ Sci & Technol, State Key Lab Digital Mfg Equipment & Technol, Wuhan, Hubei, Peoples R China.
    High purity and viability cell separation of a bacterivorous jakobid flagellate based on a steep velocity gradient induced soft inertial force2018In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 8, no 62, p. 35512-35520Article in journal (Refereed)
    Abstract [en]

    Cell separation is one of the key limiting factors for precise analysis of non-axenic microbial lab cultures or environmental samples, and it remains a challenge to isolate target cells with high purity and viability via high-throughput cell sorting. During the past decade, hydrodynamic microfluidic platforms have attracted great attention in cell preparation for their high efficiency, robust performance and low cost. Here, we employ the use of a low-velocity sheath flow with high viscosity near the wall and a high-velocity sheath flow with low viscosity on the other side of the sample flow in a soft inertial separation chip. This not only prevents hard interactions between cells and chip walls but, in comparison to previous inertial separation methods, generates a significant increase in deflection of large cells while keeping the small ones in the original flow. We first conducted experiments on a mixture of small and large fluorescent particles (1.0 and 9.9 m, respectively) and removed over 99% of the small particles. The separation efficiency was then tested on a culture of a bacterivorous jakobid flagellate, Seculamonas ecuadoriensis fed on the live bacterium, Klebsiella sp. Using our microfluidic chip, over 94% of live bacteria were removed while maintaining high jakobid cell viability. For comparison, we also conducted size-based cell sorting of the same culture using flow cytometry, which is widely used as a rapid and automated separation tool. Compared with the latter, our chip showed more than 40% higher separation efficiency. Thus, our device provides high purity and viability for cell separation of a sensitive cell sample (jakobid cells). Potentially, the method can be further used for applications in diagnostics, biological analyses and environmental assessment of mixed microbial samples.

  • Lindgren, Charlotte
    et al.
    Dalarna University, School of Humanities and Media Studies, French.
    Ädel, Annelie
    Dalarna University, School of Humanities and Media Studies, English.
    Johansson, Sören
    Dalarna University, School of Humanities and Media Studies, Sound and Music Production.
    Feedback på skrivuppgifter: Charlotte Lindgren samtalar med Annelie Ädel om en undersökning av feedback på skrivuppgifter vid Högskolan Dalarna2018Other (Other (popular science, discussion, etc.))
  • Järnbert-Pettersson, Hans
    et al.
    Vixner, Linda
    Dalarna University, School of Education, Health and Social Studies, Medical Science.
    Labour Q1 pain - poorly analysed and reported: a systematic review2018In: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 18, no 1, article id 483Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Modelling and analysing repeated measures data, such as women's experiences of pain during labour, is a complex topic. Traditional end-point analyses such as t-tests, ANOVA, or repeated measures [rANOVA] have known disadvantages. Modern and more sophisticated statistical methods such as mixed effect models provide flexibility and are more likely to draw correct conclusions from data. The aim of this study is to study how labour pain is analysed in repeated measures design studies, and to increase awareness of when and why modern statistical methods are suitable with the aim of encouraging their use in preference of traditional methods.

    METHODS: Six databases were searched with the English language as a restriction. Study eligibility criteria included: Original studies published between 1999 and 2016, studying pregnant women in labour with the aim to compare at least two methods for labour pain management, with at least two measurements of labour pain separated by time, and where labour pain was analysed. After deduplication, all records (n = 2800) were screened by one of the authors who excluded ineligible publication types, leaving 737 records remaining for full-text screening. A sample of 309 studies was then randomly selected and screened by both authors.

    RESULTS: Among the 133 (of 309) studies that fulfilled the study eligibility criteria, 7% used mixed effect models, 20% rANOVA, and 73% used end-point analysis to draw conclusions regarding treatment effects for labour pain between groups. The most commonly used end-point analyses to compare groups regarding labour pain were t-tests (57, 43%) and ANOVA (41, 31%). We present a checklist for clinicians to clarify when mixed effect models should be considered as the preferred choice for analysis, in particular when labour pain is measured.

    CONCLUSIONS: Studies that aim to compare methods for labour pain management often use inappropriate statistical methods, and inaccurately report how the statistical analyses were carried out. The statistical methods used in analyses are often based on assumptions that are not fulfilled or described. We recommend that authors, reviewers, and editors pay greater attention to the analysis when designing and publishing studies evaluating methods for pain relief during labour.

  • Kreitschmann-Andermahr, Ilonka
    et al.
    Univ Duisburg Essen, Dept Neurosurg, D-45147 Essen, Germany.
    Siegel, Sonja
    Univ Duisburg Essen, Dept Neurosurg, D-45147 Essen, Germany.
    Gammel, Christa
    Univ Hosp Erlangen, Dept Neurosurg, D-91054 Erlangen, Germany.
    Campbell, Karen
    Cushings Support & Res Fdn, Plymouth, MA 02360 USA.
    Edwin, Leslie
    Cushings Support & Res Fdn, Plymouth, MA 02360 USA.
    Grzywotz, Agnieszka
    Univ Duisburg Essen, Dept Neurosurg, D-45147 Essen, Germany.
    Kuhna, Victoria
    Ev Hosp Oldenburg, Dept Neurosurg, D-26121 Oldenburg, Germany.
    Koltowska-Häggström, Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Mueller, Oliver
    Univ Duisburg Essen, Dept Neurosurg, D-45147 Essen, Germany.
    Buchfelder, Michael
    Univ Hosp Erlangen, Dept Neurosurg, D-91054 Erlangen, Germany.
    Kleist, Bernadette
    Univ Duisburg Essen, Dept Neurosurg, D-45147 Essen, Germany.
    Support Needs of Patients with Cushing's Disease and Cushing's Syndrome: Results of a Survey Conducted in Germany and the USA2018In: International Journal of Endocrinology, ISSN 1687-8337, E-ISSN 1687-8345, article id 9014768Article in journal (Refereed)
    Abstract [en]

    Background. Cushing's disease (CD) and Cushing's syndrome (CS) are chronic illnesses, characterized by symptoms of prolonged hypercortisolism, which often changes to hypocortisolism after successful treatment. In view of the high disease burden of CD/CS patients and long-term impaired quality of life, the present survey was conducted to gain information about subjective illness distress and patients' specific needs in terms of supportive measures beyond medical interventions. Patients and Methods. Cross-sectional questionnaire study including patients with CD treated in 2 German neurosurgical tertiary referral centers and CD/CS patient members of a US-based patient support group completed a survey inquiring about disease burden, coping strategies, and support needs. Additionally, the degree of interest in different offers, e.g., internet-based programs and seminars, was assessed. Results. 84 US and 71 German patients answered the questionnaire. Patients in both countries indicated to suffer from Cushing-related symptoms, reduced performance, and psychological problems. 48.8% US patients and 44.4% German patients stated that good medical care and competent doctors helped them the most in coping with the illness. US patients were more interested in support groups (p = 0.035) and in courses on illness coping (p = 0.008) than the German patients, who stated to prefer brochures (p = 0.001). 89.3% of US patients would attend internet-based programs compared to 75.4% of German patients (p = 0.040). There were no differences between groups for the preferred duration of and the willingness to pay for such a program, but US patients would travel longer distances to attend a support meeting (p = 0.027). Conclusion. Patients in both countries need skilled physicians and long-term medical care in dealing with the effects of CD/CS, whereas other support needs differ between patients of both countries. The latter implies that not only disease-specific but also culture-specific training programs would need to be considered to satisfy the needs of patients in different countries.

  • Public defence: 2019-01-25 10:00 4301 Kollegiesalen, Stockholm
    Pham, Cong-Toan
    KTH, School of Electrical Engineering and Computer Science (EECS), Electromagnetic Engineering.
    Assessment of energy storage systems for power system applications based on equivalent circuit modeling2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Climate change triggered the rethinking of our current energy system. A restructuring is necessary and in progress with the goal to improve our energy supplychain in efficiency and sustainability. This has led to the increased use of renewable energy sources such as solar and wind power. In 2017 wind power surpassed all other sources, including oil, nuclear, coal, except gas in terms of total installed capacity. Renewable energy sources became an integral part in our energy systemand will continue to grow in the future. However, what is often forgotten ist hat these sources introduce high variability in the provision of power. Variability implies a lack of control over the availability of electricity, which seldom matches with the concurrent demand. Energy storages have been highlighted as a viable solution in managing arising imbalances and maintaining the security of supply. Nevertheless, numerous technologies and application possibilities exist, each unique in their characteristics and requirements. Not every energy storage works in every situation, which naturally raises the question: How can we choose the optimal storage for any application?

    To answer this question we developed an unified model approach for all energy storages based on the equivalent circuit model. The key idea is to provide a direct way of comparing and assessing energy storages, i.e., by simulating and analyzing their performances for different applications. Differences in performance become visible in investigating the dynamic behavior. We proposed a general model, which effectively represents energy storages of different types (electrical, mechanical, hydraulicetc.) and includes their main characteristics (also non-linearity). Secondly, the proposed models have been validated through an experimental setup to test energy storages under changing operations. Subsequently, a sizing routine has been implemented to optimally size an energy storage system for any type of application. Based on this approach the energy storages can be easily compared and important key parameters such as efficiency, rated power, energy capacity etc., can be derived. Finally, the proposed models and methods are applied to various power system applications. A suitability index is introduced to measure the qualification of an individual energy storage for the selected applications. Alternatively, an evaluation method based on fuzzy logic has been explored. Both suitability index and fuzzy logic can effectively determine and rank the suitability of energy storages.

  • Lidestam, Björn
    Swedish National Road and Transport Research Institute, Traffic and road users, Driver and vehicle.
    Läsbarhet och synbarhet av vägmärken med reflexfolie: ett fältexperiment i mörker samt enkätstudier2018Report (Other academic)
    Abstract [en]

    Background: Road signs are crucial for informing road users and need to be bright enough to be visible and readable, but not so bright that they cause glare. The brightness levels of road signs should also be appropriate for the vast majority of road users.

    Purpose: The purpose was to evaluate readability of road signs of retroreflection classes RA2 and RA3B, with regard to factors affecting the retroreflection per se, amount of light onto the signs, and how well the driver sees. Objective measures of reading distance and visual status, and subjective measures of how different categories of drivers experience that they detect, read, and experience glare from road signs were also to be taken into account.

    Methods: A field experiment measured reading distance (and visual acuity and contrast); and questionnaire studies measured opinions and experiences from different driver categories concerning driving in darkness in general, and about properties of road signs in darkness in particular.

  • Hellner, Brynolf
    The Nordic Museum.
    Garnityrmöbeln1950In: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1950, p. 7-24Chapter in book (Other academic)
  • Nygren, Gunnar
    et al.
    Södertörn University, School of Social Sciences, Journalism.
    Schjærff Engelbrecht, Nønne
    Södertörn University, School of Social Sciences.
    Vita fläckar och medieskuggor - stora skillnader i mediernas kommunbevakning2018In: Mediestudiers årsbok: Tillståndet för journalistiken 2017/2018 / [ed] Lars Truedson, Stockholm: Institutet för Mediestudier , 2018, p. 22-53Chapter in book (Other academic)
    Abstract [sv]

    De lokala mediernas kommunbevakning lever – men den är ojämnt fördelad. I högbevakade kommuner kan medborgarna ta del av 50-60 nyheter varje vecka som berör den lokala politiken och kommunens verksamhet. I lågbevakade kommuner stannar det på 5-10 nyheter varje vecka, varav många notiser och insändare.

    Kommunbevakningen har vissa gemensamma drag i alla typer av kommuner: de dominerande källorna är kommunpolitiker och tjänstemän, den vanligaste typen av konflikter handlar om missnöjda medborgare mot kommunen. Kritik mot kommunen finns mest i opinionsmaterial, två av tre nyhetsartiklar är positiva gentemot kommunen. Men det finns också skillnader i bevakningen mellan hög- och lågbevakade kommuner. Siffrorna tyder på att det är en ”snällare” bevakning i lågbevakade kommuner – färre konflikter, mindre kritik mot kommunen och mer positiva nyheter.

    Finns det då ”vita fläckar” i kommunbevakningen, delar av landet som inte bevakas alls av några lokala eller regionala nyhetsmedier? Det korta svaret är nej. Ingen av de 17 kommunerna saknade helt mediebevakning under den aktuella veckan. Men studien visar också att det finns mycket stora skillnader både i omfång på bevakningen och hur bevakningen ser ut. Medieskuggorna ligger tunga över landsbygdskommuner utan lokalredaktioner och storstädernas förorter som ofta har en gratistidning som enda nyhetskälla.

  • Ekström, Camilla
    et al.
    Swedish National Road and Transport Research Institute, Traffic and road users, Traffic Safety and Traffic System.
    Forsman, Åsa
    Swedish National Road and Transport Research Institute, Traffic and road users, Traffic Safety and Traffic System.
    Förekomst av alkohol och droger hos förare av lastbil och buss som varit inblandade i dödsolyckor och olyckor med svåra personskador2018Report (Other academic)
    Abstract [en]

    The aim of this study was to improve the knowledge about the presence of alcohol, drugs and medicine among drivers of trucks or busses involved in fatal accidents and accidents with severe injuries. The study is based on material from two different databases, the Swedish Transport Administrations in-depth study database and the Swedish Traffic Accident Data Acquisition (Strada), owned by The Swedish Transport Agency. The survey of the presence of substances and background variables such as gender, age and type of accident among drivers under influence is presented in this study and based on accidents that occurred 2008–2015. The study includes 614 fatal accidents from the in-depth study database and 3381 accidents with severe injuries from Strada.

    For fatally injured drivers of trucks and busses in the in-depth database presence of alcohol was found in 15 percent, illegal drugs in 6 percent and medicine in 9 percent. Compared to the corresponding figure for drivers of cars, the presence of alcohol is lower, whereas the presence for illegal drugs and medicine, is at the same level. The presence is much lower when studying all drivers of trucks and busses involved in fatal accidents disregarding the drivers level of injury. The presence of alcohol among the drivers were 2 percent and 1 percent for illegal drugs respectively medicine. There are though differences between the type of vehicle driven. Among drivers of lighter trucks 16 of 156 drivers (10%) had presence of alcohol and/or illegal drugs. For drivers of trucks 4 of 369 (1%) and drivers of busses 0 of 96 drivers (0%) where under the influence of alcohol and/or illegal drugs.

  • Public defence: 2019-01-15 09:15 Q221, Östersund
    Klingvall Ek, Rebecca
    Mid Sweden University, Faculty of Science, Technology and Media, Department of Quality Management and Mechanical Engineering.
    Electron beam melting: Impact of part surface properties on metal fatigue and bone ingrowth2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Abstract

    The aim of this thesis is to investigate aspects on how additive manufacturing (AM) contributes to functional bone implants with the use of the electron beam melting (EBM) technology. AM manufactures parts according to computer-aided design, and the EBM technology melts powder using an electron beam, which acts similar to a laser beam. The topics discussed in this thesis are related to surface roughness that originate from the melted metal powder, and the thesis tries to define some aspects that affect implant functionality. Process parameters steering the electron beam and biocompatibility arising from the surface texture were the initial parts of the PhD studies, and the other half focused on post-processing and fatigue, which are important for medical and industrial applications. There are six studies in this compilation thesis. They are abbreviated as P - process parameters, M - medical applications, and F - fatigue. Studies P, M2, F2, and F3 are journal articles, and M1 and F1 are conference proceedings.

    Study P used design of experiments to investigate how process parameters affect the surface roughness of as-built EBM-manufactured parts and concluded that beam speed and energy (current) were the most important parameters that influence the surface roughness.

    In studies M1 and M2, EBM-manufactured specimens of cobalt-chromium and titanium alloys were used to evaluate biocompatibility. The blood chamber method quantified the reactions of the human whole blood in contact with the metal surfaces, and the results showed how the as-built EBM surface roughness contributed to coagulation and bone healing.

    Rotating beam fatigue equipment was used in studies F1–F3 and study F1 discussed the size effect on fatigue loaded as-built specimens and included specimens with different sizes and with or without hot isostatic pressing (HIP). Study F2 compared as-built and machined specimens and study F3 investigated how Hirtisation, which is a patented electrochemical surface treatment, and HIP affect the fatigue properties that originate from the electrochemical polishing surface topography. The studies showed that a decreased surface roughness increased the fatigue resistance while the stress concentrations (Kt) in the surface of EBM-manufactured specimens decreased.

    The thesis concludes that EBM-manufactured as-built surfaces are suitable for direct contact with the bone, and that HIP does not improve the fatigue resistance of parts with as-built surfaces, where crack initiation starts at notches.

  • Wu, Pianpian
    et al.
    Kainz, Martin J.
    Bravo, Andrea Garcia
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Åkerblom, Staffan
    Sonesten, Lars
    Bishop, Kevin
    The importance of bioconcentration into the pelagicfood web base for methylmercury biomagnification: A meta-analysis2019In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 646, p. 357-367Article in journal (Refereed)
    Abstract [en]

    Methylmercury (MeHg) transfer from water into the base of the food web (bioconcentration) and subsequent biomagnification in the aquatic food web leads to most of the MeHg in fish. But how important is bioconcentration compared to biomagnification in predicting MeHg in fish? To answer this question we reviewed articles in which MeHg concentrations in water, plankton (seston and/or zooplankton), as well as fish (planktivorous and small omnivorous fish) were reported. This yielded 32 journal articles with data from 59 aquatic ecosystems at 22 sites around the world. Although there are many case studies of particular aquatic habitats and specific geographic areas that have examined MeHg bioconcentration and biomagnification, we performed a meta-analysis of such studies. Aqueous MeHg was not a significant predictor of MeHg in fish, but MeHg in seston i.e., the base of the aquatic food web, predicted 63% of the variability in fish MeHg. The MeHg bioconcentration factors (i.e., transfer of MeHg from water to seston; BCFw-s) varied from 3 to 7 orders of magnitude across sites and correlated significantly with MeHg in fish. The MeHg biomagnification factors from zooplankton to fish varied much less (logBMFz-f, 0.75 ± 0.31), and did not significantly correlate with fish MeHg, suggesting that zooplanktivory is not as important as bioconcentration in the biomagnification of fish MeHg across the range of ecosystems represented in our meta-analysis. Partial least square (PLS) and linear regression analyses identified several environmental factors associated with increased BCF, including low dissolved organic carbon, low pH, and oligotrophy. Our study reveals the widespread importance of MeHg bioconcentration into the base of the aquatic food web for MeHg at higher trophic levels in aquatic food webs, as well as the major influences on the variability in this bioconcentration.

  • Gaborit, Mathieu
    et al.
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Marcus Wallenberg Laboratory MWL. Université du Maine, Le Mans France.
    Göransson, Peter
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, MWL Numerical acoustics. KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Marcus Wallenberg Laboratory MWL. KTH, School of Engineering Sciences (SCI), Centres, VinnExcellence Center for ECO2 Vehicle design. Centre for ECO2 Vehicle Design.
    Dazel, Olivier
    Université du Maine, Le Mans France.
    Simplification of the transfer matrix model for acoustic screens2018Conference paper (Refereed)
  • Mantzouki, Evanthia
    et al.
    Bravo, Andrea Garcia
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Urrutia Cordero, Pablo
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Buck, Moritz
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Colom-Montero, William
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    Pierson, Don
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Limnology.
    A European Multi Lake Survey dataset of environmental variables , phytoplankton pigments and cyanotoxins2018In: Scientific Data, E-ISSN 2052-4463, Vol. 5, no October, p. 1-13Article in journal (Refereed)
    Abstract [en]

    Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face multiple stressors that threaten their functioning. Harmful cyanobacterial blooms are a persistent problem resulting from nutrient pollution and climate-change induced stressors, like poor transparency, increased water temperature and enhanced stratification. Consistency in data collection and analysis methods is necessary to achieve fully comparable datasets and for statistical validity, avoiding issues linked to disparate data sources. The European Multi Lake Survey (EMLS) in summer 2015 was an initiative among scientists from 27 countries to collect and analyse lake physical, chemical and biological variables in a fully standardized manner. This database includes in-situ lake variables along with nutrient, pigment and cyanotoxin data of 369 lakes in Europe, which were centrally analysed in dedicated laboratories. Publishing the EMLS methods and dataset might inspire similar initiatives to study across large geographic areas that will contribute to better understanding lake responses in a changing environment.

  • Segnestam Larsson, Ola
    et al.
    Ersta Sköndal Bräcke University College, Department of Social Sciences, The Institute for Civil Society Research.
    Wagndal, Mats
    Statistiska centralbyrån.
    Det frivilliga arbetet i Sverige som del av BNP2018Report (Other academic)
  • Rising Holmström, Malin
    et al.
    Mid Sweden University, Faculty of Human Sciences, Department of Nursing Sciences.
    Häggström, Marie
    Mid Sweden University, Faculty of Human Sciences, Department of Nursing Sciences.
    Söderberg, Siv
    Mid Sweden University, Faculty of Human Sciences, Department of Nursing Sciences.
    Experiences from Parents to Children with Diabetes Type 1.2018In: JSM Health Education Primary Health Care, ISSN 2578-3777, Vol. 3, no 2, article id 1044Article in journal (Refereed)
    Abstract [en]

    Introduction: When a child is diagnosed with a long-term illness such as diabetes type 1(DT1) parents often find it stressful to give optimum support to the child and to manage the situation especially when the child is in school. Parents experience that the stress to manage life with Diabetes Type 1, means to constant monitor blood glucose, to assist with insulin injections, food intake and physical activity, in order to optimum disease management. Aim: To explore how parents’ of children with Diabetes Type 1 experienced their role as a parent. Material and method: A qualitative design was used and individual interviews were conducted with a purposive sample of 13 parents (10 mothers and 3 fathers) of children with Diabetes Type 1. The interviews were analyzes using qualitative content analysis. Results and conclusions: The analysis resulted in one theme A life change revealing new needs with four subthemes; Struggling with fear and searching for explanations, Learning to manage and getting control of a lifelong illness, Collaboration with school as an important support and Managing the illness influenced work and family finances. Parents in this study struggled for their children at all times, to be the child’s caregiver and to take care of the child’s life in the best possible way. They asked for flexible and continue diabetes education for themselves and for school staff efficient communication and cooperation between parents/families, healthcare and school.

  • de Boniface, J.
    et al.
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden;Capio St Gorans Hosp, Breast Ctr, Dept Surg, Sankt Goransplan 1, SE-11281 Stockholm, Sweden.
    Frisell, J.
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden;Karolinska Univ Hosp, Dept Breast & Endocrine Surg, Stockholm, Sweden.
    Bergkvist, Leif
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Vastmanland Cty Hosp, Dept Surg, Vasteras, Sweden.
    Andersson, Yvette
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Vastmanland Cty Hosp, Dept Surg, Vasteras, Sweden.
    Breast-conserving surgery followed by whole-breast irradiation offers survival benefits over mastectomy without irradiation2018In: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 105, no 12, p. 1607-1614Article in journal (Refereed)
    Abstract [en]

    Background: The prognostic equivalence between mastectomy and breast-conserving surgery (BCS) followed by radiotherapy was shown in pivotal trials conducted decades ago. Since then, detection and treatment of breast cancer have improved substantially and recent retrospective analyses point towards a survival benefit for less extensive breast surgery. Evidence for the association of such survival data with locoregional recurrence rates is largely lacking.

    Methods: The Swedish Multicentre Cohort Study prospectively included clinically node-negative patients with breast cancer who had planned sentinel node biopsy between 2000 and 2004. Axillary lymph node dissection was undertaken only in patients with sentinel node metastases. For the present investigation, adjusted survival analyses were used to compare patients who underwent BCS and postoperative radiotherapy with those who received mastectomy without radiotherapy.

    Results: Of 3518 patients in the Swedish Multicentre Cohort Study, 2767 were included in the present analysis; 2338 had BCS with postoperative radiotherapy and 429 had mastectomy without radiotherapy. Median follow-up was 156 months. BCS followed by whole-breast irradiation was superior to mastectomy without irradiation in terms of both overall survival (79.5 versus 64.3 per cent respectively at 13 years; P < 0.001) and breast cancer-specific survival (90.5 versus 84.0 per cent at 13 years; P < 0.001). The local recurrence rate did not differ between the two groups. The axillary recurrence-free survival rate at 13 years was significantly lower after mastectomy without irradiation (98.3 versus 96.2 per cent; P < 0.001).

    Conclusion: The present data support the superiority or BCS with postoperative radiotherapy over mastectomy without radiotherapy. The axillary recurrence rate differed significantly, and could be one contributing factor in a complex explanatory model.