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  • Mays, Chris
    et al.
    Swedish Museum of Natural History, Department of Paleobiology.
    Bevitt, Joseph
    Australian Nuclear Science and Technology Organisation, Research Office, B3, New Illawarra Road, Lucas Heights, NSW 2234, Australia.
    Stilwell, Jeffrey
    School of Earth, Atmosphere and Environment, Monash University, 9 Rainforest Walk, Clayton, Victoria 3800, Australia.
    Pushing the limits of neutron tomography in palaeontology: Three-dimensional modelling of in situ resin within fossil plants2017In: Palaeontologia Electronica, ISSN 1935-3952, E-ISSN 1094-8074, Vol. 20, no 3.57A, 1-12 p.Article in journal (Refereed)
    Abstract [en]

    Computed tomography is an increasingly popular technique for the non-destructive

    study of fossils. Whilst the science of X-ray computed tomography (CT) has greatly

    matured since its first fossil applications in the early 1980s, the applications and limitations

    of neutron tomography (NT) remain relatively unexplored in palaeontology. These

    highest resolution neutron tomographic scans in palaeontology to date were conducted

    on a specimen of Austrosequoia novae-zeelandiae (Ettingshausen) Mays and Cantrill

    recovered from mid-Cretaceous (Cenomanian; ~100–94 Ma) strata of the Chatham

    Islands, eastern Zealandia. Previously, the species has been identified with in situ fossil

    resin (amber); the new neutron tomographic analyses demonstrated an anomalously

    high neutron attenuation signal for fossil resin. The resulting data provided a

    strong contrast between, and distinct three-dimensional representations of the: 1) fossil

    resin; 2) coalified plant matter; and 3) sedimentary matrix. These data facilitated an

    anatomical model of endogenous resin bodies within the cone axis and bract-scale

    complexes. The types and distributions of resin bodies support a close alliance with

    Sequoia Endlicher (Cupressaceae), a group of conifers whose extant members are

    only found in the Northern Hemisphere. This study demonstrates the feasibility of NT

    as a means to differentiate chemically distinct organic compounds within fossils.

    Herein, we make specific recommendations regarding: 1) the suitability of fossil preservation

    styles for NT; 2) the conservation of organic specimens with hydrogenous consolidants

    and adhesives; and 3) the application of emerging methods (e.g., neutron

    phase contrast) for further improvements when imaging fine-detailed anatomical structures.

    These findings demonstrate that we are still far from reaching the conceptual

    limits of NT as a means of virtually extracting fossils, or imaging their internal anatomy

    even when embedded within a rock matrix.

  • Slater, Sam
    et al.
    Swedish Museum of Natural History, Department of Paleobiology.
    McKie, Tom
    Shell UK Ltd., 1 Altens Farm Road, Nigg, Aberdeen AB12 3FY, UK.
    Vieira, Manuel
    UK Ltd., 1 Altens Farm Road, Nigg, Aberdeen AB12 3FY, UK.
    Wellmann, Charles
    Department of Animal and Plant Sciences, University of Sheffield, Alfred Denny Building,Western Bank, Sheffield S10 2TN, UK.
    Vajda, Vivi
    Swedish Museum of Natural History, Department of Paleobiology. Department of Geology, Lund University, Sweden.
    Episodic river flooding events revealed by palynological assemblages inJurassic deposits of the Brent Group, North Sea2017In: Palaeogeography, Palaeoclimatology, Palaeoecology, ISSN 0031-0182, E-ISSN 1872-616X, Vol. 485, 389-400 p.Article in journal (Refereed)
    Abstract [en]

    Spore and pollen (sporomorph) assemblages from Middle Jurassic marine deposits of the Brent Group in the northern North Sea are investigated to assess temporal and spatial variations in vegetation and depositional processes. Four wells were sampled for palynology from the Penguins Cluster and the Don North East fields through the Rannoch Formation shoreface succession. Hyperpycnite deposits occur throughout, but are concentrated within the lower part of the section. These are expressed by sand-prone beds displaying waxing and waning current motifs, normally graded muddy beds and structureless mudstones. Hyperpycnal/hypopycnal deposits resulting from episodic river flooding represent important sedimentary features as they may be preserved below fair weather wave base in more offshore settings and potentially be the only record of the former presence of a nearby river mouth. The hyperpycnites typically contain abundant Botryoccocus spp., Amorphous Organic Matter (AOM) and hinterland sporomorph taxa with relatively few marine components compared to associated marine shoreface facies. Variations in palynofacies assemblages and Botryococcus spp. abundances indicate frequent river mouth avulsion. Ordination of samples using non-metric multidimensional scaling (NMDS) indicates that shoreface samples of the sampled wells are relatively distinct, but hyperpycnite samples are highly similar regardless of their sampled well. This suggests that depositional processes and spore/pollen sources (i.e. catchment zones) were similar among hyperpycnite events across different wells. Abundant bisaccate pollen, Botryococcus spp. and AOM within interpreted hyperpycnites suggest sediment mixing along the fluvial drainage path during flooding events. The terrestrial signature of hyperpycnite sporomorph assemblages demonstrates that underflows remained coherent as they descended the shoreface profile with little turbulent mixing with ambient marine waters. Sporomorph assemblages display few large changes through time suggesting vegetation on the adjacent coastal plain was relatively static through the studied interval.

  • Almandoz-Gil, Leire
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Lindström, Veronica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Sigvardson, Jessica
    BioArctic, Stockholm, Sweden.
    Kahle, Philipp J.
    Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat, Lab Funct Neurogenet, Tubingen, Germany.;German Ctr Neurodegenerat Dis, Tubingen, Germany..
    Lannfelt, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Ingelsson, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Bergström, Joakim
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein2017In: Cellular and molecular neurobiology, ISSN 0272-4340, E-ISSN 1573-6830, Vol. 37, no 7, 1217-1226 p.Article in journal (Refereed)
    Abstract [en]

    Aggregated alpha-synuclein is the main component of Lewy bodies, intraneuronal deposits observed in Parkinson's disease and dementia with Lewy bodies. The objective of the study was to identify surface-exposed epitopes of alpha-synuclein in vitro and in vivo formed aggregates. Polyclonal immunoglobulin Y antibodies were raised against short linear peptides of the alpha-synuclein molecule. An epitope in the N-terminal region (1-10) and all C-terminal epitopes (90-140) were found to be exposed in an indirect enzyme-linked immunosorbent assay (ELISA) using recombinant monomeric, oligomeric, and fibrillar alpha-synuclein. In a phospholipid ELISA, the N-terminus and mid-region of alpha-synuclein (i.e., 1-90) were associated with phosphatidylserine and thus occluded from antibody binding. The antibodies that reacted most strongly with epitopes in the in vitro aggregates (i.e., 1-10 and epitopes between positions 90-140) also labeled alpha-synuclein inclusions in brains from transgenic (Thy-1)-h[A30P] alpha-synuclein mice and Lewy bodies and Lewy neurites in brains of patients with alpha-synucleinopathies. However, differences in reactivity were observed with the C-terminal antibodies when brain tissue from human and transgenic mice was compared. Taken together, the study shows that although similar epitopes are exposed in both in vitro and in vivo formed alpha-synuclein inclusions, structural heterogeneity can be observed between different molecular species.

  • Högberg, Sören
    Dalarna University, School of Education, Health and Social Studies, Education.
    Att låta det oväntade ge rum åt det oförväntade: Möjligheter inom ramen för skolämnet samhällskunskap2017In: Nordidactica: Journal of Humanities and Social Science Education, ISSN 2000-9879, no 2, 25-43 p.Article in journal (Refereed)
    Abstract [en]

    The aim of the article is to illuminate the opportunities for students in social studies to develop dispositions towards taking an active and responsible role in society when teachers are able to support the content of the subject to continuously come forward in an interactive, communicative and evolving process. Based on theoretical informed arguments the author claims that that the question of how the teaching process is carried out is deeply connected with these opportunities for creating meaningful pedagogical situations. Here, unforeseen events are discussed as desirable circumstances for engaging students in social issues. However, this also brings risk into the process since the content discussed and how it is discussed opens up for unexpected answers. These answers which become part of the course content, put the teacher in a position in which he or she needs to respond in one way or another. In such pedagogical situations, the moral dimension of teachers’ work becomes visible and obvious. The position is taken that risk is a crucial part of a teaching process in which one of the aims is for students to be and become active, responsible and engaged in social issues.

  • Spiegelberg, Diana
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Nilvebrant, Johan
    Royal Inst Technol, Div Prot Technol, Sch Biotechnol, Stockholm, Sweden..
    CD44v6-Targeted Imaging of Head and Neck Squamous Cell Carcinoma: Antibody-Based Approaches2017In: Contrast Media & Molecular Imaging, ISSN 1555-4309, E-ISSN 1555-4317, Vol. 2017, 2709547Article, review/survey (Refereed)
    Abstract [en]

    Head and neck squamous cell carcinoma (HNSCC) is a common and severe cancer with low survival rate in advanced stages. Noninvasive imaging of prognostic and therapeutic biomarkers could provide valuable information for planning and monitoring of the different therapy options. Thus, there is amajor interest in development of new tracers towards cancer-specific molecular targets to improve diagnostic imaging and treatment. CD44v6, an oncogenic variant of the cell surface molecule CD44, is a promising molecular target since it exhibits a unique expression pattern in HNSCC and is associated with drug-and radio-resistance.

    In this review we summarize results from preclinical and clinical investigations of radiolabeled anti-CD44v6 antibody-based tracers: full-length antibodies, Fab, F(ab')(2) fragments, and scFvs with particular focus on the engineering of various antibody formats and choice of radiolabel for the use as molecular imaging agents in HNSCC. We conclude that the current evidence points to CD44v6 imaging being a promising approach for providing more specific and sensitive diagnostic tools, leading to customized treatment decisions and functional diagnosis. Improved imaging tools hold promise to enable more effective treatment for head and neck cancer patients.

  • Hamid Muhammed, Hamed
    et al.
    School of Technology and Health (STH), Royal Institute of Technology (KTH), Alfred Nobels Alle 10, SE-141 52 Huddinge, Sweden.
    Azar, Jimmy C
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computerized Image Analysis and Human-Computer Interaction.
    Automatic Characterization of the Physiological Condition of the Carotid Artery in 2D Ultrasound Image Sequences Using Spatiotemporal and Spatiospectral 2D Maps.2014In: International Journal of Biomedical Imaging, ISSN 1687-4188, E-ISSN 1687-4196, Vol. 2014, 876267Article in journal (Refereed)
    Abstract [en]

    A novel method for characterizing and visualizing the progression of waves along the walls of the carotid artery is presented. The new approach is noninvasive and able to simultaneously capture the spatial and the temporal propagation of wavy patterns along the walls of the carotid artery in a completely automated manner. Spatiotemporal and spatiospectral 2D maps describing these patterns (in both the spatial and the frequency domains, resp.) were generated and analyzed by visual inspection as well as automatic feature extraction and classification. Three categories of cases were considered: pathological elderly, healthy elderly, and healthy young cases. Automatic differentiation, between cases of these three categories, was achieved with a sensitivity of 97.1% and a specificity of 74.5%. Two features were proposed and computed to measure the homogeneity of the spatiospectral 2D map which presents the spectral characteristics of the carotid artery wall's wavy motion pattern which are related to the physical, mechanical (e.g., elasticity), and physiological properties and conditions along the artery. These results are promising and confirm the potential of the proposed method in providing useful information which can help in revealing the physiological condition of the cardiovascular system.

  • Setting the stage for asustainable food future: Seven takeaways fromNordic Food Day at COP232017Other (Other (popular science, discussion, etc.))
    Abstract [en]

    How can the Nordic countries address pressing global challenges like food waste, unsustainable diets and the loss of biodiversity? This very question was the starting point for Nordic Food Day on the 9th of November. The Nordic Pavilion at COP23 was transformed into a pop-up think tank, bringing representatives from leading organizations and institutions, together to discuss how to put food policy on the climate agenda. The thematic day, Nordic Food Day, was the kick-off of the Nordic Food Policy Lab. www.norden.org/nordicfoodday

  • Jonason, Patricia
    et al.
    Södertörns högskola, Offentlig rätt.
    Rosengren, AnnaJönköping University, School of Engineering, JTH, Industrial Engineering and Management.
    The Right of Access to Information and the Right to Privacy: A Democratic Balancing Act2017Collection (editor) (Other academic)
    Abstract [en]

    This publication gathers presentations from an international and trans-disciplinary workshop held at Södertörn University in December 2016.

    The workshop entitled The Right of Access to Information and the Right to Privacy: A Democratic Balancing Act was one of the many events which celebrated the 250th anniversary of the Swedish Freedom of the Press Act, the first legal instrument in the world laying down the right of access to official documents. A starting point for the workshop was the assumption that the right of access to information and the right to privacy are both necessary pre-conditions for a democratic society. Researchers from a broad range of fields were invited to discuss how these assumptions should be examined, and how the balance between the two interests should be assessed when conflicting with each other. The objective of the workshop was to broaden our understanding of various national and disciplinary approaches to the democratic balance between the right of access and the right to privacy.

    Among the conclusions we may draw from the workshop, and the articles emanating from it, is the confirmation of the need to strike the balance between the right of access and the right to privacy. This is certainly difficult, but since the two interests are both of such importance for democracy, we constantly need to make the effort. The articles in this volume contain information on some of the areas that need our further attention.

  • Asratian, Armen
    Department of Mathematics, University of Umeå, Sweden / Department of Mathematical Cybernetics, Yerevan State University, Yerevan, Republic of Armenia.
    Every 3-connected, locally connected, claw-free graph is Hamilton-connected1996In: Journal of Graph Theory, ISSN 0364-9024, E-ISSN 1097-0118, Vol. 23, no 2, 191-201 p.Article in journal (Refereed)
    Abstract [en]

    A graph G is locally connected if the subgraph induced by the neighbourhood of each vertex is connected. We prove that a locally connected graph G of order p ≥ 4, containing no induced subgraph isomorphic to K1,3, is Hamilton-connected if and only if G is 3-connected. © 1996 John Wiley & Sons, Inc.

  • Nordiskt samarbetsprogram för närings- och innovationspolitik 2018-212017Other (Other (popular science, discussion, etc.))
    Abstract [sv]

    Vi i Norden står inför ett antal utmaningar när det gäller att fortsätta skapa tillväxt och sysselsättning i alla delar av de nordiska länderna, så att vi kan fortsätta stärka välfärden och sammanhållningen. Samarbetsprogrammet beskriver de viktigaste samarbetsområdena och anger en tydlig riktning för det nordiska näringspolitiska samarbetet. Med samarbetsprogrammet kommer de nordiska ministrarna att 1) säkerställa en snabb omställningsförmåga, 2) stärka innovations- och konkurrenskraften och 3) förbättra globala marknadsmöjligheter. Ministrarna kommer också att samarbeta för att främja nordiska intressen i EU. Samarbetsprogrammet ska säkerställa en stor genomslagskraft och förankring i länderna. Det utgår från och bygger på de nordiska ländernas prioriteringar och nationella satsningar inom näringspolitiken samt bygger vidare på tidigare framgångsrika nordiska satsningar och relevanta FN 2030-mål för hållbar utveckling.

  • Kulessa, Bernd
    et al.
    Swansea Univ, Glaciol Grp, Coll of Sci.
    Hubbard, Alun L.
    UiT Arctic Univ Norway, Ctr Arctic Gas Hydrate Environm & Climate, Dept Geosci.; Aberystwyth Univ, Ctr Glaciol, Dept Geog & Earth Sci.
    Booth, Adam D.
    Univ Leeds, Inst Appl Geosci, Sch Earth & Environm.
    Bougamont, Marion
    Univ Cambridge, Scott Polar Res Inst, Dept Geog.
    Dow, Christine F.
    Swansea Univ, Glaciol Grp, Coll Sci, Singleton Pk.; Univ Waterloo, Dept Geog & Environm Management.
    Doyle, Samuel H.
    Aberystwyth Univ, Ctr Glaciol, Dept Geog & Earth Sci.
    Christoffersen, Poul
    Univ Cambridge, Scott Polar Res Inst, Dept Geog.
    Lindback, Katrin
    Norwegian Polar Res Inst, Fram Ctr.
    Pettersson, Rickard
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL.
    Fitzpatrick, Andrew A. W.
    Aberystwyth Univ, Ctr Glaciol, Dept Geog & Earth Sci.
    Jones, Glenn A.
    Swansea Univ, Glaciol Grp, Coll of Sci.; Aberystwyth Univ, Ctr Glaciol, Dept Geog & Earth Sci.
    Seismic evidence for complex sedimentary control of Greenland Ice Sheet flow2017In: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 3, no 8, e1603071Article in journal (Refereed)
    Abstract [en]

    The land-terminating margin of the Greenland Ice Sheet has slowed down in recent decades, although the causes and implications for future ice flow are unclear. Explained originally by a self-regulating mechanism where basal slip reduces as drainage evolves from low to high efficiency, recent numerical modeling invokes a sedimentary control of ice sheet flow as an alternative hypothesis. Although both hypotheses can explain the recent slowdown, their respective forecasts of a long-term deceleration versus an acceleration of ice flow are contradictory. We present amplitude-versus-angle seismic data as the first observational test of the alternative hypothesis. We document transient modifications of basal sediment strengths by rapid subglacial drainages of supraglacial lakes, the primary current control on summer ice sheet flow according to our numerical model. Our observations agree with simulations of initial postdrainage sediment weakening and ice flow accelerations, and subsequent sediment restrengthening and ice flow decelerations, and thus confirm the alternative hypothesis. Although simulated melt season acceleration of ice flow due to weakening of subglacial sediments does not currently outweigh winter slowdown forced by self regulation, they could dominate over the longer term. Subglacial sediments beneath the Greenland Ice Sheet must therefore be mapped and characterized, and a sedimentary control of ice flow must be evaluated against competing self-regulation mechanisms.

  • Youth, democracy, and democratic exclusion in the Nordic countries2017Other (Other (popular science, discussion, etc.))
    Abstract [en]

    Young people in the Nordic countries participate less in elections than the overall population. The turnout is lowest among youth in their early twenties. Meanwhile, Nordic youth have high rates of participation when it comes to other forms of democratic participation. Certain groups of Nordic youth in particular have low turnouts. Youth with non-western or Eastern European immigrant background, with low levels of education, low income, that have parents with low educational levels, and who are children of non-voters have strikingly lower turnouts.Several successful and partly successful measures to increase youth turnout have been carried out in the Nordic countries. It is essential that Nordic politicians and policymakers prioritise the work towards increasing the turnout of youth. If not, we may risk the permanent de facto exclusion from democracy of certain groups.

  • Asratian, Armen
    et al.
    Department of Mathematical Cybernetics, Yerevan State University, Yerevan, Republic of Armenia.
    Kamalian, R. R.
    Computing Centre, Academy of Sciences of the Republic of Armenia, Yerevan, Republic of Armenia.
    Investigation on Interval Edge-Colorings of Graphs1994In: Journal of combinatorial theory. Series B (Print), ISSN 0095-8956, E-ISSN 1096-0902, Vol. 62, no 1, 34-43 p.Article in journal (Other academic)
    Abstract [en]

    An edge-coloring of a simple graph G with colors 1, 2,..., t is called an interval t-coloring [3] if at least one edge of G is colored by color i, i = 1, ..., t and the edges incident with each vertex x are colored by dG(x) consecutive colors, where dG(x) is the degree of the vertex x. In this paper we investigate some properties of interval colorings and their variations. It is proved, in particular, that if a simple graph G = (V, E) without triangles has an interval t-coloring, then t ≤ |V| − 1.

  • Witasse, O.
    et al.
    European Space Agcy, ESTEC.
    Sanchez-Cano, B.
    Univ Leicester, Dept Phys & Astron, Radio & Space Plasma Phys Grp.
    Mays, M. L.
    NASA Goddard Space Flight Ctr, Heliophys Sci Div.
    Kajdic, P.
    Univ Nacl Autonoma Mexico, Inst Geofis.
    Opgenoorth, Hermann
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Elliott, H. A.
    Southwest Res Inst, San Antonio.
    Richardson, I. G.
    NASA Goddard Space Flight Ctr, Heliophys Sci Div.;Univ Maryland, Dept Astron.
    Zouganelis, I.
    European Space Agcy, ESAC, Villanueva De La Canada.
    Zender, J.
    European Space Agcy, ESTEC.
    Wimmer-Schweingruber, R. F.
    Univ Kiel, Inst Expt & Appl Phys.
    Turc, L.
    European Space Agcy, ESTEC.
    Taylor, M. G. G. T.
    European Space Agcy, ESTEC.
    Roussos, E.
    Max Planck Inst Solar Syst Res Justus von Liebig.
    Rouillard, A.
    IRAP, Toulouse.
    Richter, I.
    Tech Univ Carolo Wilhelmina Braunschweig, Inst Geophys & Extraterrestrial Phys.
    Richardson, J. D.
    MIT, Ctr Space Res, Cambridge.
    Ramstad, R.
    Swedish Inst Space Phys, IRF, Kiruna.
    Provan, G.
    Univ Leicester, Dept Phys & Astron, Radio & Space Plasma Phys Grp.
    Posner, A.
    NASA Headquarters, Sci Miss Directorate.
    Plaut, J. J.
    Jet Prop Lab, Pasadena.
    Odstrcil, D.
    George Mason Univ, Dept Phys & Astron.;NASA Goddard Space Flight Ctr, Space Weather Lab.
    Nilsson, H.
    Swedish Inst Space Phys, IRF, Kiruna.
    Niemenen, P.
    European Space Agcy, ESTEC.
    Milan, S. E.
    Univ Leicester, Dept Phys & Astron, Radio & Space Plasma Phys Grp.
    Mandt, K.
    Southwest Res Inst, San Antonio.; UTSA, Dept Phys & Astron, San Antonio.
    Lohf, H.
    Univ Kiel, Inst Expt & Appl Phys.
    Lester, M.
    Univ Leicester, Dept Phys & Astron, Radio & Space Plasma Phys Grp.
    Lebreton, J. -P
    Univ Orleans, CNRS, LPC2E.
    Kuulkers, E.
    European Space Agcy, ESTEC.
    Krupp, N.
    Max Planck Inst Solar Syst Res Justus von Liebig.
    Koenders, C.
    Tech Univ Carolo Wilhelmina Braunschweig, Inst Geophys & Extraterrestrial Phys.
    James, M. K.
    Univ Leicester, Dept Phys & Astron, Radio & Space Plasma Phys Grp.
    Intzekara, D.
    European Space Agcy, ESTEC.; European Space Agcy, ESAC, Villanueva De La Canada.
    Holmstrom, M.
    Swedish Inst Space Phys, IRF, Kiruna.
    Hassler, D. M.
    Southwest Res Inst, Boulder.; Inst Astrophys Spatiale, Orsay.
    Hall, B. E. S.
    Univ Leicester, Dept Phys & Astron, Radio & Space Plasma Phys Grp.
    Guo, J.
    Univ Kiel, Inst Expt & Appl Phys.
    Goldstein, R.
    Southwest Res Inst, San Antonio.
    Goetz, C.
    Tech Univ Carolo Wilhelmina Braunschweig, Inst Geophys & Extraterrestrial Phys.
    Glassmeier, K. H.
    Tech Univ Carolo Wilhelmina Braunschweig, Inst Geophys & Extraterrestrial Phys.
    Genot, V.
    IRAP, Toulouse.
    Evans, H.
    European Space Agcy, ESTEC.
    Espley, J.
    Goddard Space Flight Ctr, Lab Planetary Magnetospheres, Greenbelt.
    Edberg, N. J. T.
    Swedish Inst Space Phys, IRF, Uppsala, Sweden..
    Edberg, Niklas J. T.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Cowley, S. W. H.
    Univ Leicester, Dept Phys & Astron, Radio & Space Plasma Phys Grp.
    Burch, J.
    Southwest Res Inst, San Antonio.
    Behar, E.
    Swedish Inst Space Phys, IRF, Kiruna.
    Barabash, S.
    Swedish Inst Space Phys, IRF, Kiruna.
    Andrews, David J.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Altobelli, N.
    European Space Agcy, ESAC, Villanueva De La Canada.
    Interplanetary coronal mass ejection observed at STEREO-A, Mars, comet 67P/Churyumov-Gerasimenko, Saturn, and New Horizons en route to Pluto: Comparison of its Forbush decreases at 1.4, 3.1, and 9.9 AU2017In: Journal of Geophysical Research - Space Physics, ISSN 2169-9380, E-ISSN 2169-9402, Vol. 122, no 8, 7865-7890 p.Article in journal (Refereed)
    Abstract [en]

    We discuss observations of the journey throughout the Solar System of a large interplanetary coronal mass ejection (ICME) that was ejected at the Sun on 14 October 2014. The ICME hit Mars on 17 October, as observed by the Mars Express, Mars Atmosphere and Volatile EvolutioN Mission (MAVEN), Mars Odyssey, and Mars Science Laboratory (MSL) missions, 44h before the encounter of the planet with the Siding-Spring comet, for which the space weather context is provided. It reached comet 67P/Churyumov-Gerasimenko, which was perfectly aligned with the Sun and Mars at 3.1 AU, as observed by Rosetta on 22 October. The ICME was also detected by STEREO-A on 16 October at 1 AU, and by Cassini in the solar wind around Saturn on the 12 November at 9.9AU. Fortuitously, the New Horizons spacecraft was also aligned with the direction of the ICME at 31.6 AU. We investigate whether this ICME has a nonambiguous signature at New Horizons. A potential detection of this ICME by Voyager 2 at 110-111 AU is also discussed. The multispacecraft observations allow the derivation of certain properties of the ICME, such as its large angular extension of at least 116 degrees, its speed as a function of distance, and its magnetic field structure at four locations from 1 to 10 AU. Observations of the speed data allow two different solar wind propagation models to be validated. Finally, we compare the Forbush decreases (transient decreases followed by gradual recoveries in the galactic cosmic ray intensity) due to the passage of this ICME at Mars, comet 67P, and Saturn.

  • Ernstsson, Olivia
    et al.
    Karolinska Institutet.
    Tinghög, Petter
    The Swedish Red Cross University College, Department of Health Sciences. Karolinska Institutet.
    Alexanderson, Kristina
    Karolinska Institutet.
    Hillert, Jan
    Karolinska Institutet.
    Burström, Kristina
    Karolinska Institutet / Stockholm County Council.
    The External Validity of Mapping MSIS-29 on EQ-5D Among Individuals With Multiple Sclerosis in Sweden2017In: Medical Decision Making Policy & Practice, ISSN 2381-4683, Vol. 2, no 1Article in journal (Refereed)
    Abstract [en]

    Background: Mapping can be performed to predict utility values from condition-specific measures when preference-based measures are absent. A previously developed algorithm that predicts EQ-5D-3L index values from the Multiple Sclerosis Impact Scale (MSIS-29) has not yet been externally validated. Aim: To examine the external validity of a previously developed mapping algorithm by testing the accuracy of predicting EQ-5D-3L index values from MSIS-29 among multiple sclerosis (MS) patients in Sweden. Methods: Cross-sectional individual-level data were collected from population-based Swedish registers between 2011 and 2014. Health-related quality of life was assessed through MSIS-29 and EQ-5D-3L at one point in time among 767 individuals with known disability level of MS. A previously developed mapping algorithm was applied to predict EQ-5D index values from MSIS-29 items, and the predictive accuracy was assessed through mean absolute error and root mean square error. Results: When applying the algorithm, the predicted mean EQ-5D-3L index value was 0.77 compared to the observed mean index value of 0.75. Prediction error was higher for individuals reporting EQ-5D values <0.5 compared to individuals reporting EQ-5D values ≥0.5. Mean absolute error (0.12) and root mean square error (0.18) were smaller or equal to the prediction errors found in the original mapping study. Conclusion: The mapping algorithm had similar predictive accuracy in the two independent samples although results showed that the highest predictive performance was found in groups with better health. Varied predictive accuracy in subgroups is consistent with previous studies and strategies to deal with this are warranted.

  • Public defence: 2018-01-26 09:00 Kollegiesalen, Stockholm
    Jerpdal, Lars
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Lightweight Structures.
    Processing of self-reinforced poly(ethylene terephthalate) composites for automotive applications2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The vehicles of the future must have less negative environmental impact during their use phase than the vehicles of today in order to avoid major climate change on earth. Consequently electric vehicles are currently under development with the purpose of reducing CO2 emissions when the vehicle is

    driven. There are also efforts put in to reducing the weight of vehicles in order to reduce the demand for energy to drive them. One important aspect of weight reduction is that new materials and technologies are developed. Plastic materials have low a density and can therefore be used to reduce the weight of vehicle components and with composite materials there is further potential for weight reduction. Self-reinforced thermoplastic composite materials are materials in which both reinforcement and matrix are thermoplastic materials and thanks to their low density and relatively good mechanical properties, these materials may be used for weight reduction of vehicle components.

     

    The aim of this thesis is to study selected process parameters for component manufacturing with self-reinforced poly(ethylene terephthalate) (SrPET) in order to increase knowledge and thereby advance the field of self-reinforced PET composites. This thesis shows that stretching the material in the manufacturing process increases the mechanical performance of the material due to increased orientation of the amorphous phase in the PET reinforcement. However, stretching introduces stresses in the material that give rise to negative shape distortions in the formed component. The degree of stretching during forming must therefore be controlled in order to achieve a robust serial production. The concept of a SrPET component over-moulded for integration of stiffeners and attachments has been evaluated in a life-cycle-assessment. This evaluation shows that the component weight can be reduced compared to technology currently in use and thereby contribute to increased sustainability of transport.

  • Odolinski, Kristofer
    et al.
    Swedish National Road and Transport Research Institute, Society, environment and transport, Transport economics.
    Lindgren, Hanna
    Swedish National Road and Transport Research Institute, Society, environment and transport, Transport economics.
    Modellering av järnvägstransporter: en översikt kring datakällor2017Report (Other academic)
    Abstract [en]

    Information on freight and passenger flows is vital for advancing knowledge on railway transport. In addition to providing a description of the current use of railway transportation, the flows of freight and passengers can be used in transport models to make transportation forecasts. Such forecasts can, for example, be used to evaluate infrastructure investments, or to analyze the impact of new restrictions or new policies. The transport statistics in Sweden are, however, quite aggregate, which makes forecasts and other types of estimations rather uncertain. There is therefore reason to describe the current modelling of railway transport, as well as its development and potential in combining different (and new) data sources to provide the information on railway transport that is requested.

    Sampers and Samgods are the national models in Sweden for freight and passenger transports, respectively. Three types of data are used in Sampers: data describing travel behavior, information about the transport network and public transport services, as well as attraction measures for trips to the different geographical zones in the model. The output from the demand model are passenger flows for each transport mode and destination. Train passengers are distributed on the railway network based on current traffic flows, while anticipated timetables are used in the forecasts. This generates information on the number of trips for each railway link during a year (that is, between stations or nodes on railway lines), as well as the number of embarking and disembarking passengers on the railway stations. These results need validation, which inter alia is performed by regions within the Swedish Transport Administration, using passenger statistics.

    Data inputs for Samgods are information on the transport network, cost data, regulations, production and consumption data and goods flows. The data on goods flows are gathered from foreign trade statistics and the national commodity flow survey. The production and consumption data are used together with the goods flows data to calculate the transported volume of 34 different commodity types between 464 zones (of which 290 are municipalities in Sweden). A separate tool called Bangods is used to generate rail freight transport on the different track sections comprising the railway network. This is based on rail traffic data, which however lacks information on the type of freight trains as well as commodity type and volume of goods per train. At present, the output for rail freight transport consists of goods flows during a year on the different track sections (about 300), segmented into different types of freight trains and 12 groups of commodities.

    Transport modelling approaches are becoming more disaggregate. More specifically, there is a development towards activity-based models for passenger transport, while modelling of logistic choices at company level is becoming more common for freight transport. This development requires more disaggregate data, in both time and space. The rapid technological development has provided new opportunities in collecting disaggregate data, notably through low prices and improved performance of the technical units required to record and communicate information on the positioning of people, goods or vehicles. Examples on data sources are data from radionavigation-satellite services (Global Positioning System, GPS), cell phone data, Radio Frequency Identification (RFID) or other types of sensors (for train weight or number of embarking and disembarking passengers).

    There are pros and cons with these different data sources in transport modelling; one type of data source cannot cover the information needs. A combination of data can therefore be a solution. For example, GPS data and cell phone data can be good complements, as the former have a higher level of detail while the latter have larger blind spots. Still, a general problem with the automatic collection of data is that only a sub-sample of the trips are captured; even though it generates more detailed information on the position and timing of trips compared to traditional travel surveys, it is still based on a sub-sample of the trips made, which can create a selection bias. Moreover, this type of data lacks information on socio-economic aspects and the purpose of the trip. However, information on work and home location can be derived from mobility patterns based on GPS or cell phone data, which in turn can be linked to socio-economic information (at least at an aggregate level). Nevertheless, information on passenger and freight flows can be useful in the calibration and validation of the transport models. For instance, train payload measurements can be used to derive information on the number of passengers on each train (potentially between all stations if the train has a weighing capability, or if enough stationary weight detectors are installed on the infrastructure). Moreover, even though the weight of a freight train does not reveal the commodity type, it can be used in the calibration of Samgods and provide a more accurate flow of goods on different trains and track sections. In other words, new technology and data collection methods provide a significant potential for generating more disaggregate data on transport flows.

  • Rizk, Aya
    et al.
    Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Computer Science.
    Konietzny, Jirka
    Luleå University of Technology, Department of Business Administration, Technology and Social Sciences, Business Administration and Industrial Engineering.
    Cassar, Mario
    Luleå University of Technology, Department of Business Administration, Technology and Social Sciences, Business Administration and Industrial Engineering.
    Wong, Richard
    KTH Royal Intstitute of Technology.
    Wallström, Åsa
    Luleå University of Technology, Department of Business Administration, Technology and Social Sciences, Business Administration and Industrial Engineering.
    Vella, Joseph
    University of Malta.
    The Taste of Ageing: a 26-Year Analysis of Publications in the International Journal of Wine Business Research2017In: Back to the Future: Using Marketing Basics to Provide Customer Value: Proceedings of the 2017 Academy of Marketing Science (AMS) Annual Conference, 2017Conference paper (Refereed)
    Abstract [en]

    This study analyses the content of the International Journal of Wine Business Research (IJWBR) and gives editors, reviewers, authors and practitioners an overview over the journal’s development over 26 years. The articles published in the journal since its inception in 1989 till 2014, inclusive, were analyzed in two time frames. The first time frame covers 1989 to 2006 as the International Journal of Wine Marketing (IJWM), while the second time frame covers 2007 to 2014 as IJWBR, the new name under which the journal re-launched. All types of articles are included in the analysis with the exception of editorials, guest editorials and research notes. Five main themes are addressed: the nature of authorship, the most prolific and influential authors, characteristics of the manuscripts, regional distribution of the wine’s region-of-origin and focal markets, and the most common research themes.

     

    The content analysis of this journal sheds light on how the style of the journal has evolved since its inception in 1989 onto the second time frame. The types of articles and methods used have been consistent in the early issues (1989-2006). However, since 2007 the journal has welcomed more academic and quantitative articles. The change motivated new authors to write longer articles, collaborate more, use more references, tables and figures. As a result, the journal’s impact has increased significantly. In addition, empirical studies published in the journal indicated an increase in the publications covering the Americas as both regions of origin and focal markets, as compared to other regions. This is the first time a content analysis has been carried out for IJWBR. The objective is to help authors identifying new and interesting research areas as well as to give editors and reviewers insight into the style and areas explored since the journal’s inception. By using software tools for data collection and analysis, the study is bound to the limitations inherent from these tools.

  • Mendoza-Galvan, A.
    et al.
    CINVESTAV, Mexico.
    Järrendahl, Kenneth
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Arwin, Hans
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Exposing different in-depth pitches in the cuticle of the scarab beetle Cotinis mutabilis2017In: MATERIALS TODAY-PROCEEDINGS, ELSEVIER SCIENCE BV , 2017, Vol. 4, no 4, 4969-4978 p., 4Conference paper (Refereed)
    Abstract [en]

    The cuticle of the scarab beetle Cotinis mutabilis reflects left-handed polarized light indicating the presence of a helicoidal structure. Different in-depth pitches in the cuticle are corroborated by optical microscopy images of the cuticle which originally is yellowish or reddish but becomes greenish after gently scratching its top side. Using the Mueller-matrix formalism the degree of polarization (total and circular) of reflected light is determined for unpolarized incident light. The effects of the finite thickness of the cuticle on the broadening and strength of the selective Bragg reflection are discussed on the basis of dispersion relations for optical modes in helicoidal structures and simulated spectra. (C) 2017 The Author(s). Published by Elsevier Ltd.

  • Public defence: 2018-01-18 09:00 B:41, Uppsala
    de Oliveira, Felipe Marques Souza
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools.
    Development and Application of Proximity Assays for Proteome Analysis in Medicine2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Along with proteins, a myriad of different molecular biomarkers, such as post-translational modifications and autoantibodies, could be used in an attempt to improve disease detection and progression. In this thesis, I build on several iterations of the proximity ligation assay to develop and apply new adaptable methods to facilitate detection of proteins, autoantibodies and post-translational modifications.

    In paper I, we present an adaptation of the solid-phase proximity ligation assay (SP-PLA) for the detection of post-translational modification of proteins (PTMs). The assay was adapted for the detection of two of the most commons PTMs present in proteins, glycosylation and phosphorylation, offering the encouraging prospect of using detection of PTMs in a diagnostic or prognostic capacity. 

    In paper II, we developed a variant of the proximity ligation assay using micro titer plate for detection and quantification of protein using optical density as readout in the fluorometer, termed PLARCA. With a detection limit considerably lower than ELISA, PLARCA detected femtomolar levels of these proteins in patient samples.

    In paper III, we aim to compare detection values of samples collected from earlobe capillary, venous plasma, as well as capillary plasma stored in dried plasma spots (DPS) assessed with a 92-plex inflammation panel using multiplex proximity extension assay (PEA). Despite the high variability in protein measurements between the three sample sources, we were able to conclude that earlobe capillary sampling is a suitable less invasive alternative, to venipuncture.

    In paper IV, we describe the application of PLARCA and proximity extension assay (PEA) for the detection of GAD65 autoantibodies (GADA). Thus, offering highly sensitive and specific autoimmunity detection.

  • Eriksson, Gunnar
    et al.
    Institute for Language and Folklore, Språkrådet.
    Karlgren, Jussi
    KTH, Teoretisk datalogi, TCS.
    Features for modelling characteristics of conversations: Notebook for PAN at CLEF 20122012In: CLEF 2012 Evaluation Labs and Workshop Online Working Notes, 2012Conference paper (Refereed)
    Abstract [en]

    In this experiment, we find that features which model interaction andconversational behaviour contribute well to identifying sexual grooming behaviourin chat and forum text. Together with the obviously useful lexical features —which we find are more valuable if separated by who generates them — weachieve very successful results in identifying behavioural patterns which maycharacterise sexual grooming. We conjecture that the general framework can beused for other purposes than this specific case if the lexical features are exchangedfor other topical models, the conversational features characterise interaction andbehaviour rather than topical choice.

  • Petillo, David
    et al.
    Orey, Stephen
    Tan, Aik Choon
    Forsgren, Lars
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Khoo, Sok Kean
    Parkinson's Disease-related Circulating microRNA Biomarkers: a Validation Study2015In: AIMS Medical Science, ISSN 2375-1576, Vol. 2, no 1, 7-14 p.Article in journal (Refereed)
    Abstract [en]

    Parkinson's disease (PD) is the second most common neurodegenerative disease. One of the major challenges in studying this progressive neurological disorder is to identify and develop biomarkers for early detection. Recently, several blood-based microRNA (miRNA) biomarkers for PD have been reported. However, follow-up studies with new, independent cohorts have been rare. Previously, we identified a panel of four circulating miRNA biomarkers for PD (miR-1826, miR-450b-3p, miR-505, and miR-626) with biomarker performance of 91% sensitivity and 100% specificity. However, the expression of miR-450b-3p could not be detected in a new, independent validation set. In our current study, we improved the detection power by including a non-biased pre-amplification step in quantitative real-time PCR (qRT-PCR) and reevaluated the biomarker performance. We found the panel of four PD-related miRNAs achieved the predictive power of 83% sensitivity and 75% specificity in our validation set. This is the first biomarker validation study of PD which showed reproducibility and robustness of plasma-based circulating miRNAs as molecular biomarkers and qRT-PCR as potential diagnostic assay.

  • Kukaj, Vera
    et al.
    Jashari, Fisnik
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Clinic of Neurology, University Clinical Center of Kosovo, 10000 Pristina, Kosovo.
    Boshnjaku, Dren
    Istrefi, Enis
    Ibrahimi, Pranvera
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Hypoglycemia-Induced Hemiparesis in a Diabetic Woman after Childbirth2015In: Case Reports in Neurological Medicine, ISSN 2090-6668, E-ISSN 2090-6676, 210613Article in journal (Refereed)
    Abstract [en]

    A 24-year-old female with type 1 diabetes mellitus presented with hemiparesis induced by hypoglycemia. She was hospitalized because she has noticed a weakness of her right hand and leg three days after childbirth. On physical examination she had an expressive dysphasia and right side hemiparesis with facial drop. Hypoglycemia is rarely associated with hemiparesis and it is often overlooked, especially when it happens in patients at higher risk of other diseases frequently associated with hemiparesis. Although sporadical cases of hypoglycemia-induced hemiparesis were reported, the clear pathophysiology behind this is not well determined. However, any individual case is important in order to increase the awareness of hypoglycemia as an important etiology of this condition.

  • Dawed, Adem Y.
    et al.
    Ali, Ashfaq
    Zhou, Kaixin
    Pearson, Ewan R.
    Franks, Paul W.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, USA.
    Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes2017In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 60, no 11, 2231-2239 p.Article in journal (Refereed)
    Abstract [en]

    Aims/hypothesis: There is an extensive body of literature suggesting the involvement of multiple loci in regulating the action of metformin; most findings lack replication, without which distinguishing true-positive from false-positive findings is difficult. To address this, we undertook evidence-based, multiple data integration to determine the validity of published evidence. Methods: We (1) built a database of published data on gene-metformin interactions using an automated text-mining approach (n = 5963 publications), (2) generated evidence scores for each reported locus, (3) from which a rank-ordered gene set was generated, and (4) determined the extent to which this gene set was enriched for glycaemic response through replication analyses in a well-powered independent genome-wide association study (GWAS) dataset from the Genetics of Diabetes and Audit Research Tayside Study (GoDARTS). Results: From the literature search, seven genes were identified that are related to the clinical outcomes of metformin. Fifteen genes were linked with either metformin pharmacokinetics or pharmacodynamics, and the expression profiles of a further 51 genes were found to be responsive to metformin. Gene-set enrichment analysis consisting of the three sets and two more composite sets derived from the above three showed no significant enrichment in four of the gene sets. However, we detected significant enrichment of genes in the least prioritised category (a gene set in which their expression is affected by metformin) with glycaemic response to metformin (p = 0.03). This gene set includes novel candidate genes such as SLC2A4 (p = 3.24 x 10(-04)) and G6PC (p = 4.77 x 10(-04)). Conclusions/interpretation: We have described a semi-automated text-mining and evidence-scoring algorithm that facilitates the organisation and extraction of useful information about gene-drug interactions. We further validated the output of this algorithm in a drug-response GWAS dataset, providing novel candidate loci for gene-metformin interactions.

  • Kilhammar, Karin
    Jönköping University, School of Education and Communication, HLK, Lifelong learning/Encell.
    Lärandemodeller i Gnosjöregionen: Utvärderingsrapport2017Report (Other academic)
    Abstract [sv]

    Kompetensförsörjning och kompetensutveckling är nyckelfaktorer för företagens konkurrenskraft och tillväxt. De villkor som framförallt småföretag verkar under, gör att satsningar på kompetens‐ utveckling ofta blir lågprioriterat. Projektet  ”Lärandemodeller i Gnosjöregionen” hade till syfte att stärka regionens konkurrenskraft genom att stödja kompetensförsörjningen för små och medelstora företag i regionen. Målet för den analysfas som den här utvärderingsrapporten omfattar var att kartlägga och ta fram tydliga, systematiska och välförankrade arbetsmodeller för att stärka individens möjligheter till livslångt lärande” (projektansökan, s 8). Arbetsmodellerna innefattade kartläggning och analys av företagens kompetens och kompetensbehov, samt matchning mellan företagens behov och utbildningsanordnares utbud. Vidare förväntades att arbetet med projektet skulle stärka kontakterna mellan enskilda företag, företagsorganisationer och utbildningsanordnare.

    Inom ramen för projektet utformades en kompetensmodell för kartläggning och analys av kompe‐ tens och kompetensbehov vid företag, där branschorganisationernas valideringsinstrument användes som bas. Modellen testades vid ett mindre företag inom skärteknik och en koncern med tre ingående företag inom gjuteribranschen.  En skiss på en utbildningsportal för att underlätta matchning mellan företagens behov och utbildningsutbudet togs också fram.  

    Projektet utvärderades genom intervjuer med medarbetare och ledning vid de två företag där modellen testades, samt genom intervjuer med styrgruppsmedlemmar och projektledning. Arbetet i projektet följdes kontinuerligt där utvärderaren tog del av dokumention, hade kontinuerliga samtal med projektledning, deltog vid styrgruppsmöten samt vid genomförande av tester och återkoppling vid de aktuella företagen.

    Resultatet visar att ledare och medarbetare vid de företag där modellen testades upplevde att modellen var relevant för ändamålet och att testerna gav en bild av vilket behov av kompetensutveckling som fanns vid företaget. Det mest framträdande problemområdet som   identifierades var att testerna inte gav rättvisa för de personer som har läs‐ och skrivsvårigheter samt bristande kunskaper i svenska språket. Där kan det krävas en utveckling av modellerna och även valideringstesterna för de ska ska ge rättvisande bild av anställdas kompetens. Kompetensmodellen uppfattades som användbar för företagen, samtidigt som det uttrycktes att det finns ett fortsatt behov av externt stöd för att genomföra kartläggning och analys.

    Kompetensmodellen har utvecklats under projektets gång och är fortfarande under utveckling. Inför den planerade ansökan för genomförandeprojekt, tydliggjordes processerna och ett arbete med dokumentation av processerna påbörjades. Detta för att tydliggöra för företagen vad modellen handlar om, så att de lättare kan ta ställning till om de vill delta i projektet och använda modellen.

    I utvärderingsrapporten analyseras resultaten  och rekommendationer ges för vad som bör läggas vikt vid i ett eventuellt genomförandeprojekt. Det huvudsakliga målet för projektets analysfas bedöms ha uppnåtts i och med att en fungerande kompetensmodell utformats och testats. Däremot har arbetet med matchningsverktygen mellan företagens behov och utbildningsutbudet i regionen inte kommit lika långt. Kontakterna mellan enskilda företag, företagsorganisationer och utbildnings‐ anordnare i regionen har inte heller stärkts i den utsträckning som önskats. Ett gediget grundarbete har dock genomförts vilket resulterat i ett värdefullt lärande för ingående parter, vilket ger en god grund för ett genomförandeprojekt.

  • Public defence: 2018-01-19 13:00 Betty Pettersson-salen (14:031), Uppsala
    Åhlén, Johan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
    Universal prevention of anxiety and depression in school children2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Anxiety and depression are common in children and adolescents, and involve individual suffering, risk of future psychiatric problems, and high costs to society. However, only a limited number of children experiencing debilitating anxiety and depression are identified and receive professional help. One approach that could possibly reduce the prevalence of these conditions is universal school-based prevention aimed at reducing the impact of risk factors and strengthening protective factors involved in the development of anxiety and depression. The current thesis aimed to contribute to the literature on universal prevention of anxiety and depression in children. Study I involved a meta-analysis of earlier randomized, and cluster-randomized trials of universal prevention of anxiety and depression. Overall, the meta-analysis showed small but significant effects of universal preventive interventions, meaning that lower levels of anxiety and depression were evident after intervention completion and partially evident at follow-up assessments. No variables were found to significantly enhance the effects, however, there was a tendency for larger effects to be associated with mental health professionals delivering the interventions. In Study II, a widely adopted prevention program called Friends for Life was evaluated in a large school-based cluster-randomized effectiveness trial. The results showed no evidence of an intervention effect for the whole sample. However, children with elevated depressive symptoms at baseline and children with teachers who highly participated in supervision, seemed to benefit from the intervention in the short term. Study III involved a 3-year follow-up of Study II and an examination of the effects of sample attrition. The results showed no long-term effects for the whole sample and no maintenance of the short-term subgroup effects observed in Study II. Finally, to increase our understanding of the development of anxiety in children and to assist future improvements of universal prevention, Study IV evaluated different trajectories of overall anxiety together with related patterns of disorder-specific symptoms in a school-based sample over 39 months. Evidence favored a model of three different developmental trajectories across age. One trajectory was characterized by increasing levels of overall anxiety, but fluctuating disorder-specific symptoms arguably related to the normal challenges of children’s developmental level, which warrants an increased focus on age-relevant challenges in universal prevention. The four studies provide further understanding of the overall effectiveness of universal prevention of anxiety and depression in children, the short- and long-term effects of universal prevention in a Swedish context, and ideas for further development of preventive interventions.    

  • Hadimeri, Ursula
    et al.
    Smedby, Örjan
    Fransson, Sven-Göran
    Stegmayr, Bernd
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Hadimeri, Henrik
    Fistula diameter correlates with echocardiographic characteristics in stable hemodialysis patients2015In: NEPHROLOGY @ POINT OF CARE, ISSN 2059-3007, Vol. 1, no 1, E44-E48 p.Article in journal (Refereed)
    Abstract [en]

    Aims and background: Left ventricular hypertrophy (LVH) is a common finding in hemodialysis patients. The aim of the present study was to investigate if the diameter of the distal radiocephalic fistula could influence left ventricular variables in stable hemodialysis patients.

    Methods: Nineteen patients were investigated. Measurements of the diameter of the arteriovenous (AV) fistula were performed in 4 different locations. The patients were investigated using M-mode recordings and measurements in the 2D image. Doppler ultrasound was also performed. Transonic measurements were performed after ultrasound investigation.

    Results: Fistula mean and maximal diameter correlated with left ventricular characteristics. Fistula flow correlated neither with the left ventricular characteristics nor with fistula diameters.

    Conclusions: The maximal diameter of the distal AV fistula seems to be a sensitive marker of LVH in stable hemodialysis patients.

  • Public defence: 2017-12-19 10:00 Q2, Stockholm
    Talebi Mazraeh Shahi, Mohammad Sadegh
    KTH, School of Electrical Engineering (EES), Automatic Control.
    Minimizing Regret in Combinatorial Bandits and Reinforcement Learning2017Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This thesis investigates sequential decision making tasks that fall in the framework of reinforcement learning (RL). These tasks involve a decision maker repeatedly interacting with an environment modeled by an unknown finite Markov decision process (MDP), who wishes to maximize a notion of reward accumulated during her experience. Her performance can be measured through the notion of regret, which compares her accumulated expected reward against that achieved by an oracle algorithm always following an optimal behavior. In order to maximize her accumulated reward, or equivalently to minimize the regret, she needs to face a trade-off between exploration and exploitation.

    The first part of this thesis investigates combinatorial multi-armed bandit (MAB) problems, which are RL problems whose state-space is a singleton. It also addresses some applications that can be cast as combinatorial MAB problems. The number of arms in such problems generically grows exponentially with the number of basic actions, but the rewards of various arms are correlated. Hence, the challenge in such problems is to exploit the underlying combinatorial structure.For these problems, we derive asymptotic (i.e., when the time horizon grows large) lower bounds on the regret of any admissible algorithm and investigate how these bounds scale with the dimension of the underlying combinatorial structure. We then propose several algorithms and provide finite-time analyses of their regret. The proposed algorithms efficiently exploit the structure of the problem, provide better performance guarantees than existing algorithms, and significantly outperform these algorithms in practice.

    The second part of the thesis concerns RL in an unknown and discrete MDP under the average-reward criterion. We develop some variations of the transportation lemma that could serve as novel tools for the regret analysis of RL algorithms. Revisiting existing regret lower bounds allows us to derive alternative bounds, which motivate that the local variance of the bias function of the MDP, i.e., the variance with respect to next-state transition laws, could serve as a notion of problem complexity for regret minimization in RL. Leveraging these tools also allows us to report a novel regret analysis of the KL-UCRL algorithm for ergodic MDPs. The leading term in our regret bound depends on the local variance of the bias function, thus coinciding with observations obtained from our presented lower bounds. Numerical evaluations in some benchmark MDPs indicate that the leading term of the derived bound can provide an order of magnitude improvement over previously known results for this algorithm.

  • Luciw, Matthew D.
    et al.
    Jarocka, Ewa
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Department of Kinesiology, Faculty of Physiotherapy, University School of Physical Education, Wroclaw 51-612, Poland.
    Edin, Benoni B.
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology.
    Multi-channel EEG recordings during 3,936 grasp and lift trials with varying weight and friction2014In: Scientific Data, E-ISSN 2052-4463, Vol. 1, 140047Article in journal (Refereed)
    Abstract [en]

    WAY-EEG-GAL is a dataset designed to allow critical tests of techniques to decode sensation, intention, and action from scalp EEG recordings in humans who perform a grasp-and-lift task. Twelve participants performed lifting series in which the object's weight (165, 330, or 660 g), surface friction (sandpaper, suede, or silk surface), or both, were changed unpredictably between trials, thus enforcing changes in fingertip force coordination. In each of a total of 3,936 trials, the participant was cued to reach for the object, grasp it with the thumb and index finger, lift it and hold it for a couple of seconds, put it back on the support surface, release it, and, lastly, to return the hand to a designated rest position. We recorded EEG (32 channels), EMG (five arm and hand muscles), the 3D position of both the hand and object, and force/torque at both contact plates. For each trial we provide 16 event times (e.g., 'object lift-off') and 18 measures that characterize the behaviour (e. g., 'peak grip force').

  • Olsson, Mats
    et al.
    Executive, Naturhistoriska riksmuseet, NRM.
    Rosendal, Elisabet
    Executive, Naturhistoriska riksmuseet, NRM.
    Sandegren, Finn
    Svenska jägareförbundet.
    Utterinventering av delar av Ljusnans och Dalälvens avrinningsområden september 19841984Report (Other academic)
  • Jeong, Yu Seon
    et al.
    KISTI, Natl Inst Supercomp & Networking, Daejeon 34141, South Korea..
    Bhattacharya, Atri
    Univ Liege, Space Sci Technol & Astrophys Res STAR Inst, Bat B5a, B-4000 Liege, Belgium..
    Enberg, Rikard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Kim, C. S.
    Yonsei Univ, Dept Phys, Seoul 03722, South Korea.;Yonsei Univ, IPAP, Seoul 03722, South Korea..
    Reno, Mary Hall
    Univ Iowa, Dept Phys & Astron, Iowa City, IA 52242 USA..
    Sarcevic, Ina
    Univ Arizona, Dept Astron, 933 N Cherry Ave, Tucson, AZ 85721 USA..
    Stasto, Anna
    Penn State Univ, Dept Phys, 104 Davey Lab, University Pk, PA 16802 USA..
    Prompt atmospheric neutrino flux from the various QCD models2017In: XLVI International Symposium On Multiparticle Dynamics (ISMD 2016) / [ed] Yoo, I K, 2017, UNSP 07002Conference paper (Refereed)
    Abstract [en]

    We evaluate the prompt atmospheric neutrino flux using the different QCD models for heavy quark production including the b quark contribution. We include the nuclear correction and find it reduces the fluxes by 10% - 50% according to the models. Our heavy quark results are compared with experimental data from RHIC, LHC and LHCb.

  • Public defence: 2018-01-19 09:00 E04, Umeå
    Gylling, Björn
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Biomarkers of one-carbon metabolism in colorectal cancer risk2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    One-carbon metabolism, a network of enzymatic reactions involving the transfer of methyl groups, depends on B-vitamins as cofactors, folate as a methyl group carrier, and amino acids, betaine, and choline as methyl group donors. One-carbon metabolism influences many processes in cancer initiation and development such as DNA synthesis, genome stability, and histone and epigenetic methylation. To study markers of one-carbon metabolism and inflammation in relation to colorectal cancer (CRC) risk, we used prediagnostic plasma samples from over 600 case participants and 1200 matched control participants in the population-based Northern Sweden Health and Disease Study cohort.

    This thesis studies CRC risk with respect to the following metabolites measured in pre-diagnostic plasma samples: 1) folate, vitamin B12, and homocysteine; 2) components of one-carbon metabolism (choline, betaine, dimethylglycine, sarcosine, and methionine); and 3) three markers of different aspects of vitamin B6 status. In addition, this thesis examines three homocysteine ratios as determinants of total B-vitamin status and their relation to CRC risk.

    In two previous studies, we observed an association between low plasma concentrations of folate and a lower CRC risk, but we found no significant association between plasma concentrations of homocysteine and vitamin B12 with CRC risk. We have replicated these results in a study with a larger sample size and found that low folate can inhibit the growth of established pre-cancerous lesions.

    Using the full study cohort of over 1800 participants, we found inverse associations between plasma concentrations of the methionine cycle metabolites betaine and methionine and CRC risk. This risk was especially low for participants with the combination of low folate and high methionine versus the combination of low folate and low methionine. Well-functioning methionine cycle lowers risk, while impaired DNA synthesis partly explains the previous results for folate.

    We used the full study cohort to study associations between CRC risk and the most common marker of vitamin B6 status, pyridoxal' 5-phosphate (PLP), and two metabolite ratios, PAr (4-pyridoxic acid/(PLP + pyridoxal)) estimating vitamin B6 related inflammatory processes and the functional vitamin B6 marker 3-hydroxykynurenine to xanthurenic acid (HK:XA). Increased vitamin B6-related inflammation and vitamin B6 deficiency increase CRC risk. Inflammation was not observed to initiate tumorigenesis.

    Total B-vitamin status can be estimated by three different recently introduced homocysteine ratios. We used the full study cohort to relate the ratios as determinants of the total B-vitamin score in case and control participants and estimated the CRC risk for each marker. Sufficient B-vitamin status as estimated with homocysteine ratios was associated with a lower CRC risk.

    These studies provide a deeper biochemical knowledge of the complexities inherent in the relationship between one-carbon metabolism and colorectal tumorigenesis. 

  • Magnusson Petzell, Erik
    Institute for Language and Folklore, Department of Dialectology, Onomastics and Folklore Research, Gothenburg.
    Did Trimalchio have a cuckoo-clock?: A Comment on Petron. Sat. 26.9.2000In: Eranos, ISSN 0013-9947, Vol. 98, 115-122 p.Article in journal (Refereed)
  • Kotljarchuk, Andrej
    et al.
    Södertörns högskola, Samtidshistoriska institutet.
    Sundström, OlleUmeå University, Faculty of Arts, Department of historical, philosophical and religious studies. Umeå universitet.
    Ethnic and Religious Minorities in Stalin’s Soviet Union: New Dimensions of Research2017Collection (editor) (Refereed)
    Abstract [en]

    This anthology presents studies of Stalinism in the ethnic and religious borderlands of the Soviet Union. The authors not only cover hitherto less researched geographical areas, but have also addressed new questions and added new source material. Most of the contributors to this anthology use a micro-historical approach. With this approach, it is not the entire area of the country, with millions of separate individuals that are in focus but rather particular and cohesive ethnic and religious communities.

    Micro-history does not mean ignoring a macro-historical perspective. What happened on the local level had an all-Union context, and communism was a European-wide phenomenon. This means that the history of minorities in the Soviet Union during Stalin’s rule cannot be grasped outside the national and international context; aspects which are also considered in this volume. The chapters of the book are case studies on various minority groups, both ethnic and religious. In this way, the book gives a more complex picture of the causes and effects of the state-run mass violence during Stalinism.

    The publication is the outcome of a multidisciplinary international research network lead by Andrej Kotljarchuk (Södertörn University, Sweden) and Olle Sundström (Umeå University, Sweden) and consisting of specialists from Estonia, France, Germany, Russia, Sweden, Ukraine and the United States. These scholars represent various disciplines: Anthropology, Cultural Studies, History and the History of Religions.

  • Magnusson Petzell, Erik
    Institute for Language and Folklore, Department of Dialectology, Onomastics and Folklore Research, Gothenburg.
    Subject Omission and Verb Initial Declaratives in Swedish2003In: Working Papers in Scandinavian Syntax, ISSN 1100-097X, no 71, 103-143 p.Article in journal (Other academic)
  • Wallström, Tove
    et al.
    Karolinska Institutet, Department of Clinical Science and Education, Women’s Clinic, Södersjukhuset.
    Jarnbert-Pettersson, Hans
    Karolinska Institutet, Department of Clinical Science and Education, Women’s Clinic, Södersjukhuset.
    Stenson, David
    Karolinska Institutet, Department of Clinical Science and Education, Women’s Clinic, Södersjukhuset.
    Åkerud, Helena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
    Darj, Elisabeth
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Norwegian University of Science and Technology, NTNU, Department of Public Health and Nursing.
    Gemzell-Danielsson, Kristina
    Karolinska University Hospital, Karolinska Institutet, Department of Women’s and Children’s Health.
    Wiberg-Itzel, Eva
    Karolinska Institutet, Department of Clinical Science and Education, Women’s Clinic, Södersjukhuset.
    Labor Induction with Orally Administrated Misoprostol: A Retrospective Cohort Study2017In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, 6840592Article in journal (Refereed)
    Abstract [en]

    Introduction. One great challenge in obstetric care is labor inductions. Misoprostol has advantages in being cheap and stable at room temperature and available in resource-poor settings.

    Material and Methods. Retrospective cohort study of 4002 singleton pregnancies with a gestational age >= 34w at Sodersjukhuset, Stockholm, during 2009-2010 and 2012-2013. Previously usedmethods of labor induction were compared with misoprostol given as a solution to drink, every second hour. Main outcome is as follows: Cesarean Section (CS) rate, acid-base status in cord blood, Apgar score < 7,5 ', active time of labor, and blood loss > 1500 ml (PPH).

    Results. The proportion of CS decreased from 26% to 17% when orally given solution of misoprostol was introduced at the clinic (p < 0.001). No significant difference in the frequency of low Apgar score (p = 0.3), low aPh in cord blood (p = 0.1), or PPH (p = 0.4) between the differentmethods of induction was studied. After adjustment for different risk factor for CS the only method of induction which was associated with CS was dinoproston** (Propess (R)) (aor = 2.9 (1.6-5.2)).

    Conclusion. Induction of labor with misoprostol, given as an oral solution to drink every second hour, gives a low rate of CS, without affecting maternal or fetal outcome.

  • Magnusson Petzell, Erik
    Institute for Language and Folklore, Department of Dialectology, Onomastics and Folklore Research, Gothenburg.
    VS-satser och subjektsutelämning2005In: Studier i svensk språkhistoria 8 / [ed] Cecilia Falk, Lars-Olof Delsing, Lund: Institutionen för nordiska språk, Lunds universitet , 2005, 231-240 p.Conference paper (Other academic)
  • Larsson Lindberg, Britta
    Jönköping University, School of Education and Communication, HLK, Praktiknära utbildningsforskning (PUF), Epistemic Cultures & Teaching Practices.
    Developing Teaching for Students with Special Needs2017Conference paper (Refereed)
  • Niska, Anna
    et al.
    Swedish National Road and Transport Research Institute, Infrastructure, Infrastructure maintenance.
    Blomqvist, Göran
    Swedish National Road and Transport Research Institute, Society, environment and transport, Environment.
    Järlskog, Ida
    Swedish National Road and Transport Research Institute, Society, environment and transport, Environment.
    Utvärdering av sopsaltning på cykelstråk i Stockholm vintern 2016/172017Report (Other academic)
    Abstract [en]

    In Stockholm, cycling as a mode of transport is promoted, especially for commuting. Public transport as well as the roadway network has reached capacity during peak hours and cycling is considered to be an advantageous alternative, since there are environmental and health benefits to gain. To encourage people to cycle during winter and at the same time reduce the number of single bicycle crashes, a high winter maintenance service level is needed. Using salt for skid control of bicycle paths could be one solution, although it has its drawbacks and difficulties. In recent years, a method using a frontmounted power broom for snow clearance and salt for de-icing (commonly called “sweep-salting”) has become popular for winter maintenance of bicycle paths in Sweden.

    In 2013 the city of Stockholm decided to try the “sweep-salting” method and evaluate its potential to improve the service level on bicycle routes for commuting. To optimize and develop the method, VTI has performed field studies every winter since 2013. These studies have included measurements of friction, road condition observations, measurements of residual salt on bicycle path surfaces, salt deposition at the side of bicycle paths, maintenance protocols and interviews with maintenance operators. Since all studies were done in field, in a real-life environment, the experimental work was designed according to the winter maintenance routines of the municipality and other prevailing conditions and circumstances. This report presents the results from the evaluation of the winter of 2016/2017.

    The evaluations show that when working successfully, the sweep-salting method creates a bare surface with higher friction than traditional ploughing and gritting. Measures must be done in time and the operating speed adjusted according to the prevailing conditions. In mild weather brine is sufficient, but with lower temperatures and heavy snowfall larger amounts of salt is needed and pre-wetted or dry salt must be used. For the method to work properly, the bicycle path construction should be of good condition without cracks or other damages in the surface. Otherwise, it is difficult to clear the surface with the broom as snow and water can be trapped in potholes and cracks, eventually creating ice patches. A sufficient drainage from the surface is also crucial as every contribution of water will dilute the salt amount on the path with a following risk of creating a slippery surface. Narrow passages and obstructing design features cause difficulties when clearing the snow, resulting in a need of larger amounts of salt to prevent icy conditions. Clearing the surface from snow and water is crucial to get a good result with the method.

  • Elfgren, Lennart
    et al.
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Structural and Fire Engineering.
    Linneberg, Poul
    COWI A/S, Lyngby, Denmark.
    Gudmundsson, Gudmundur Valur
    Vegagerdin - The Icelandic Road and coastal Administration.
    Leivo, Markku
    VTT Technical Research Centre of Finland.
    Köhler, Jochen
    Norwegian University of Science and Technology.
    Quality Control Plans for European Concrete Road Bridges: Experiences from Cooperation within COST Action TU 14062017In: Proceedings of the 23rd Nordic Concrete Research Symposium, Oslo, Norway, Oslo: Nordic Concrete Federation , 2017, 249-252 p.Conference paper (Refereed)
    Abstract [en]

    The main objective of the COST Action TU1406 is to develop a guideline for the establishment of Quality Control plans for roadway bridges by integrating the most recent knowledge on performance assessment procedures. 36 European countries are working together in this endeavor during 2015-2019.

  • Public defence: 2018-01-12 09:00 Betula, Umeå
    Henriksson, Tommy
    Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Sports medicine. Umeå University, Faculty of Social Sciences, Umeå Centre for Gender Studies (UCGS).
    Physiological- and Socio-Cultural Conditions for Performance in Women's Ice Hockey2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Background: The ice hockey community is founded on masculine norms and values, and the hockey rink is often described as “the home of men’s ice hockey”. Despite a growing popularity, women’s ice hockey has low priority in comparison to the men’s game. On top of that, the women’s game does not allow body checking, which makes it deviant from what some see as “the real game of ice hockey”. The checking prohibition causes physiological requirements to differ from the men’s game, and since women are underrepresented in ice hockey research, not much is known regarding the physiological- and socio-cultural conditions of women’s ice hockey. The overall aim of this doctoral thesis is to investigate physiological- and socio-cultural conditions important for performance in women’s ice hockey.

    Methods: This thesis is unique in terms of the interdisciplinary approach between physiology and gender science, and the inclusion of studies based on both qualitative and quantitative research methods. Qualitative thematic interviews with ice hockey coaches from Sweden, Canada, and the United States were used to explore socio-cultural conditions in relation to performance and sport development (Paper I). Relative age effect (RAE) in relation to maturity status was examined through anthropometric measurements and a player questionnaire (Paper II). Physiological field- and laboratory assessments were used to investigate physiological conditions and performance in female competitive ice hockey players from Sweden (Paper III-IV), and players from Canada (Paper IV).

    Results: The findings from Paper I suggest that coaches need to maintain a holistic approach to coaching to be able to coordinate and optimize the effects based on available conditions. Socio-cultural conditions, such as structural and financial support, are mentioned as important to support opportunities in women’s ice hockey. Furthermore, the results (Paper I) show that female players in Canada and the United States have superior opportunities compared to female players in Sweden. These advantages are mainly attributed to the support provided by the North American education systems. The findings from Paper II suggest that the relative age effect (RAEs) in women’s hockey are also influenced by socio-cultural conditions. Significant RAE (p<.05) was found for Swedish players born in the third quartile (Q3) and for Canadian player born in the second quartile (Q2). Players born in the fourth quartile (Q4) are significantly (p<.05) underrepresentated in both countries. Players tend to be average or late maturers, but no differences can be found by country or position. The findings from Paper III show that field-based assessments are comparable to laboratory assessments with the purpose of predicting skating performance. The Prediction models accounted for 13.6 % to 42 % (laboratory-based models) and 24.4 to 66.3 % (field-based models) of the variance in skating time. Regardless of assessment method, uni-lateral assessments are superior to bi-lateral assessments. The results support the use of field-based assessments in Paper IV. The findings from Paper IV show various physiological profiles for female Swedish and Canadian players. Swedish players had less body fat (p=.007), more lean mass (p=.005), and greater aerobic fitness measured with the20-meter shuttle run beep test (p=<.001). Canadian players had greater maximal isometric leg strength (p=.026), exhibit a greater running acceleration (p=<.001), performed better in single leg standing long jumps (right leg p=.002, left leg p=.030), and showed better anaerobic endurance (p=.029) on- ice. No significant differences can be found between forwards and defenders.

    Conclusion: The findings of this study show that physiological- and socio-cultural conditions should both be considered in relation to performance in women’s ice hockey. For example, the various physiological profiles are probably an effect of the different socio-cultural conditions in Sweden and Canada. The Canadian profile may be better adapted to performance in ice hockey, but further research is needed to establish a relationship. Since women’s ice hockey often has somewhat limited resources, this knowledge may help optimize the effect of the available resources, and thus improve performance. Improved performance may have a positive long-term effect on the symbolic view of women’s ice hockey. Women can probably further optimize their physical performance in relation to their current conditions. But for permanent changes to occur, power structures in sport must also change. Women themselves have limited opportunities to affect the dominating gender norms and values in ice hockey.

  • Rosén, Jenny
    et al.
    Dalarna University, School of Humanities and Media Studies, Swedish as Second Language.
    Straszer, Boglárka
    Dalarna University, School of Humanities and Media Studies, Swedish as Second Language.
    Wedin, Åsa
    Dalarna University, School of Humanities and Media Studies, Swedish as Second Language. Högskolan Dalarna.
    Transspråkande i studiehandledning som pedagogisk praktik2017In: Lisetten, ISSN 1101-5128, no 1, 16-19 p.Article in journal (Other (popular science, discussion, etc.))
  • Bäckström, David
    et al.
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Eriksson Domellöf, Magdalena
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Granåsen, Gabriel
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Linder, Jan
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Mayans, Sofia
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
    Elgh, Eva
    Umeå University, Faculty of Social Sciences, Department of Psychology.
    Zetterberg, H.
    Blennow, K.
    Forsgren, Lars
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease2018In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 137, no 1, 91-98 p.Article in journal (Refereed)
    Abstract [en]

    Objectives: Cognitive decline is common in Parkinson's disease (PD), but the underlying mechanisms for this complication are incompletely understood. Genotypes affecting dopamine transmission may be of importance. This study investigates whether genotypes associated with reduced prefrontal dopaminergic tone and/or reduced dopamine D2-receptor availability (Catechol-O-methyltransferase [COMT] Val(158)Met genotype and DRD2 (CT)-T-957 genotype) affect the development of cognitive deficits in PD.

    Materials and methods: One hundred and 34 patients with idiopathic PD, participating in a regional, population-based study of incident parkinsonism, underwent genotyping. After extensive baseline investigations (including imaging and biomarker analyses), the patients were followed prospectively during 6-10 years with neuropsychological evaluations, covering six cognitive domains. Cognitive decline (defined as the incidence of either Parkinson's disease mild cognitive impairment [PD-MCI] or dementia [PDD], diagnosed according to published criteria and blinded to genotype) was studied as the primary outcome.

    Results: Both genotypes affected cognition, as shown by Cox proportional hazards models. While the COMT(158)Val/Val genotype conferred an increased risk of mild cognitive impairment in patients with normal cognition at baseline (hazard ratio: 2.13, P=.023), the DRD2(957)T/T genotype conferred an overall increased risk of PD dementia (hazard ratio: 3.22, P<.001). The poorer cognitive performance in DRD2(957)T/T carriers with PD occurred mainly in episodic memory and attention.

    Conclusions: The results favor the hypothesis that dopamine deficiency in PD not only relate to mild cognitive deficits in frontostriatal functions, but also to a decline in memory and attention. This could indicate that dopamine deficiency impairs a wide network of brain areas.

  • Pettersson, Tove
    Stockholm University, Faculty of Social Sciences, Department of Criminology. Dept of Criminology 312.
    Betydelse av öppenhet under institutionstiden för ungdomar dömda till sluten ungdomsvård.: Hur påverkar det vardagen vid institutionen och återfall i brott?2017Report (Other academic)
    Abstract [sv]

    Unga brottslingar dömda till sluten ungdomsvård är en grupp som i hög utsträckning återfaller i brott eller fortsätter sin kriminella karriär in i vuxen ålder. Insatser som kan minska antalet återfall är angeläget för både förövarna själv, potentiella nya offer och samhället som helhet.

    I rapporten redovisas resultat från en studie som undersöker på vilket sätt öppenhet under institutionstiden är relaterad till återfall i brott fem år efter sluten ungdomsvård och vilken betydelse öppenheten har för vardagen på institutionen. Sammantaget visar resultaten att öppnare former bidrar till en bättre miljö för ungdomarna och minskar andelen ungdomar som återfaller i brott.

  • Krefl, Daniel
    et al.
    CERN, Theoret Phys Dept, CH-1211 Geneva 23, Switzerland..
    Seong, Rak-Kyeong
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Machine learning of Calabi-Yau volumes2017In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 96, no 6, 066014Article in journal (Refereed)
    Abstract [en]

    We employ machine learning techniques to investigate the volume minimum of Sasaki-Einstein base manifolds of noncompact toric Calabi-Yau three-folds. We find that the minimum volume can be approximated via a second-order multiple linear regression on standard topological quantities obtained from the corresponding toric diagram. The approximation improves further after invoking a convolutional neural network with the full toric diagram of the Calabi-Yau three-folds as the input. We are thereby able to circumvent any minimization procedure that was previously necessary and find an explicit mapping between the minimum volume and the topological quantities of the toric diagram. Under the AdS/CFT correspondence, the minimum volumes of Sasaki-Einstein manifolds correspond to central charges of a class of 4d N = 1 superconformal field theories. We therefore find empirical evidence for a function that gives values of central charges without the usual extremization procedure.

  • Blom Västberg, Oskar
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, System Analysis and Economics.
    Five papers on large scale dynamic discrete choice models of transportation2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Travel demand models have long been used as tools by decision makers and researchers to analyse the effects of policies and infrastructure investments. The purpose of this thesis is to develop a travel demand model which is: sensitive to policies affecting timing of trips and time-space constraints; is consistent with microeconomics; and consistently treats the joint choice of the number of trips to perform during day as well as departure time, destination and mode for all trips. This is achieved using a dynamic discrete choice model (DDCM) of travel demand. The model further allows for a joint treatment of within-day travelling and between-day activity scheduling assuming that individuals are influenced by the past and considers the future when deciding what to do on a certain day.

    Paper I develops and provides estimation techniques for the daily component of the proposed travel demand model and present simulation results provides within sample validation of the model. Paper II extends the model to allow for correlation in preferences over the course of a day using a mixed-logit specification. Paper III introduces a day-to-day connection by using an infinite horizon DDCM. To allow for estimation of the combined model, Paper III develops conditions under which sequential estimation can be used to estimate very large scale DDCM models in situations where: the discrete state variable is partly latent but transitions are observed; the model repeatedly returns to a small set of states; and between these states there is no discounting, random error terms are i.i.d Gumble and transitions in the discrete state variable is deterministic given a decision.

    Paper IV develops a dynamic discrete continuous choice model for a household deciding on the number of cars to own, their fuel type and the yearly mileage for each car. It thus contributes to bridging the gap between discrete continuous choice models and DDCMs of car ownership.

    Infinite horizon DDCMs are commonly found in the literature and are used in, e.g., Paper III and IV in this thesis. It has been well established that the discount factor must be strictly less than one for such models to be well defined.Paper V show that it is possible to extend the framework to discount factors greater than one, allowing DDCM's to describe agents that: maximize the average utility per stage (when there is no discounting); value the future greater than the present and thus prefers improving sequences of outcomes implying that they take high costs early and reach a potential terminal state sooner than optimal.

  • Kotljarchuk, Andrej
    Södertörn University, School of Historical and Contemporary Studies, Institute of Contemporary History.
    Propaganda of Hatred and the Great Terror: A Nordic Approach2017In: Ethnic and Religious Minorities in Stalin's Soviet Union: New Dimensions of Research / [ed] Andrej Kotljarchuk; Olle Sundström, Huddinge: Södertörns högskola, 2017, 91-121 p.Chapter in book (Refereed)
  • Kotljarchuk, Andrej
    et al.
    Södertörn University, School of Historical and Contemporary Studies, Institute of Contemporary History.
    Sundström, Olle
    Umeå University.
    Introduction: The Problem of Ethnic and Religious Minorities in Stalin's Soviet Union2017In: Ethnic and Religious Minorities in Stalin's Soviet Union: New Dimensions of Research / [ed] Andrej Kotljarchuk; Olle Sundström, Huddinge: Södertörns högskola, 2017, 15-30 p.Chapter in book (Refereed)
  • Arevalo, Liliana
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity. Ludvika ULHC, ABB Power Grids Grid Integrat HVDC, Dept Res & Dev, Lyviksvagen 3, S-77180 Lyviksvagen, Sweden..
    Cooray, Vernon
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Unstable Leader Inception Criteria of Atmospheric Discharges2017In: Atmosphere, ISSN 2073-4433, E-ISSN 2073-4433, Vol. 8, no 9, 156Article in journal (Refereed)
    Abstract [en]

    In the literature, there are different criteria to represent the formation of a leader channel in short and long gap discharges. Due to the complexity of the physics of the heating phenomena, and the limitations of the computational resources, a simplified criterion for the minimum amount of electrical charge required to incept an unstable leader has recently been used for modeling long gap discharges and lightning attachments. The criterion is based on the assumption that the total energy of the streamer is used to heat up the gas, among other principles. However, from a physics point of view, energy can also be transferred to other molecular processes, such as rotation, translation, and vibrational excitation. In this paper, the leader inception mechanism was studied based on fundamental particle physics and the energy balance of the gas media. The heating process of the plasma is evaluated with a detailed two-dimensional self-consistent model. The model is able to represent the streamer propagation, dark period, and unsuccessful leaders that may occur prior to the heating of the channel. The main processes that participate in heating the gas are identified within the model, indicating that impact ionization and detachment are the leading sources of energy injection, and that recombination is responsible for loss of electrons and limiting the energy. The model was applied to a well-known experiment for long air gaps under positive switching impulses reported in the literature, and used to validate models for lightning attachments and long gap discharges. Results indicate that the streamer-leader transition depends on the amount of energy transferred to the heating process. The minimum electric charge required for leader inception varies with the gap geometry, the background electric field, the reduction of electric field due to the space charge, the energy expended on the vibrational relation, and the environmental conditions, among others.

  • Tamburini, Fabrizio
    et al.
    ZKM, Lorentzstr 19, D-76135 Karlsruhe, Germany.;MSC BW, Nobelstr 19, D-70550 Stuttgart, Germany..
    De laurentis, Mariafelicia
    Goethe Univ, Inst Theoret Phys, Max von Laue Str 1, D-60438 Frankfurt, Germany.;Tomsk State Pedag Univ, Ul Kievskaya 60, Tomsk 634061, Russia.;Tomsk State Univ Control Syst & Radioelectron TUS, Lab Theoret Cosmol, Tomsk 634050, Russia.;INFN, Sez Napoli, Compl Univ Monte S Angelo,Edificio G,Via Cinthia, I-80126 Naples, Italy..
    Licata, Ignazio
    Inst Sci Methodol ISEM, I-90146 Palermo, Italy.;Sch Adv Int Studies Theoret & Nonlinear Methodol, I-70124 Bari, Italy.;BM Birla Sci Ctr, IIAMIS, Hyderabad 500463, Andhra Pradesh, India..
    Thide, Bo
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Twisted Soft Photon Hair Implants on Black Holes2017In: Entropy, ISSN 1099-4300, E-ISSN 1099-4300, Vol. 19, no 9, 458Article in journal (Refereed)
    Abstract [en]

    Background: The Hawking-Perry-Strominger (HPS) work states a new controversial idea about the black hole (BH) information paradox, where BHs maximally entropize and encode information in their event horizon area, with no "hair" thought to reveal information outside but angular momentum, mass, and electric charge only in a unique quantum gravity (QG) vacuum state. New conservation laws of gravitation and electromagnetism, appear to generate different QG vacua, preserving more information in soft photon/graviton hair implants. We find that BH photon hair implants can encode orbital angular momentum (OAM) and vorticity of the electromagnetic (EM) field. Methods: Numerical simulations are used to plot an EM field with OAM emitted by a set of dipolar currents together with the soft photon field they induce. The analytical results confirm that the soft photon hair implant carries OAM and vorticity. Results: a set of charges and currents generating real EM fields with precise values of OAM induce a "curly", twisted, soft-hair implant on the BH with vorticity and OAM increased by one unit with respect to the initial real field. Conclusions: Soft photon implants can be spatially shaped ad hoc, encoding structured and densely organized information on the event horizon.