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  • Karlsson, Torbjörn
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Hematologi. Uppsala Univ Hosp, Ctr Oslers Dis, Uppsala, Sweden;Vastmanlands Hosp, Dept Med, Vasteras, Sweden.
    Cherif, Honar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Hematologi. Uppsala Univ Hosp, Ctr Oslers Dis, Uppsala, Sweden.
    Mutations in the ENG, ACVRL1, and SMAD4 genes and clinical manifestations of hereditary haemorrhagic telangiectasia: experience from the Center for Osler's Disease, Uppsala University Hospital2018Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, nr 3, s. 153-157Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aim: The aim of this retrospective single-centre study was to evaluate whether mutations in the ENG, ACVRL1, and SMAD4 genes were associated with different phenotypes in hereditary haemorrhagic telangiectasia (HHT).

    Methods: The case records of 21 HHT patients with verified mutations in ENG, ACVRL1, or SMAD4 genes were reviewed. The numbers of HHT diagnostic criteria fulfilled for the three genotypes were compared, as was the prevalence of complications such as iron deficiency anaemia, gastrointestinal haemorrhage, stroke, and cerebral abscess.

    Results: Our results indicate that mutations in the ENG (HHT1), ACVRL1 (HHT2), and SMAD4 genes result in different HHT phenotypes. Epistaxis debuts earlier and may be more severe in HHT1 than in HHT2. The prevalence of pulmonary arteriovenous malformations (AVM) is higher in HHT type 1, whereas hepatic AVMs are more common in HHT2. One patient with mutations in both ENG and ACVRL1 genes was identified, as were two SMAD4-mutated patients suffering from the overlapping juvenile polyposis-HHT syndrome. Nearly one in five patients in our HHT population has been diagnosed with stroke or cerebral abscess, indicating a high prevalence of cerebral complications.

    Conclusion: Our results showing that ENG and ACVRL1 gene mutations result in different HHT phenotypes confirm the results from other HHT centres worldwide. Cerebral complications of HHT are common, underscoring the importance of regular screening for pulmonary AVMs and early intervention against such AVMs. We have identified an HHT patient with simultaneous mutations in the ENG and ACVRL1 genes. Surprisingly, this patient has had a mild course of the disease.

  • Barkelind, Malin
    Bobcatsss 2018 i Riga2018Inngår i: Tidskrift för ABM, ISSN 2002-4614, Vol. 3, nr 1, s. 40-48Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Bobcatsss är en biblioteks- och informationsvetenskapskonferens som anordnas årligen av studenter. Årets tema var läsning och författaren berättar här om några intressanta föredrag och infallsvinklar som inspirerade denne. Konferensen hölls i Riga och författaren besökte bland annat Lettlands nya nationalbibliotek och världsarvet Vecrīga, Rigas historiska centrum

  • Hayashi, Masaki
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för speldesign.
    Neurodrug: Slapstick Effects by Destroying Neurons in a Neural Network2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    We propose a method to possibly generate slapstick effects by deliberately cutting out, tampering and re-connecting neurons in the neural network which has been trained in a proper way. We have developed two applications of a drumbeat generator and a CG character animation as the experiments to try out the idea. The results look interesting and show a certain potential for entertainment and also a viable way of interactive art.

  • Hayashi, Masaki
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för speldesign.
    Bachelder, Steven
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för speldesign.
    Tsuruta, Naoya
    Tokyo University of Technology, Tokyo, Japan.
    Sasaki, Kazuo
    Tokyo University of Technology, Tokyo, Japan.
    Kondo, Kunio
    Tokyo University of Technology, Tokyo, Japan.
    Wordpress-based Blog System with a Capability of Showing Entries by TV-program-like CG Animations2018Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    We have developed a blog system with Wordpress which has a capability of automatically converting its blog entries into CG animations. By embedding necessary functions in Wordpress' s theme, a user can select this theme and construct a blog where readers can watch CG animation instead of reading the blog entry. The CG animation is created by TVML (TV program Making Language) technology which enables to make a TV-program-like animation with CG characters with synthesized voices, image data display, sound data playback, superimposing and so on. Not only to contribute to the Wordpress community, in particular, expected as an auxiliary function of the blog service, but also this could work as a production tool for creating various types of CG animations rather than blogging assistance.

  • Apruzzi, Fabio
    et al.
    Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA;Univ N Carolina, Dept Phys, Chapel Hill, NC 27599 USA.
    Heckman, Jonathan J.
    Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA.
    Morrison, David R.
    Univ Calif Santa Barbara, Dept Math, Santa Barbara, CA 93106 USA;Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA.
    Tizzano, Luigi
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik.
    4D gauge theories with conformal matter2018Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 9, artikkel-id 088Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    One of the hallmarks of 6D superconformal field theories (SCFTs) is that on a partial tensor branch, all known theories resemble quiver gauge theories with links comprised of 6D conformal matter, a generalization of weakly coupled hypermultiplets. In this paper we construct 4D quiverlike gauge theories in which the links are obtained from compactifications of 6D conformal matter on Riemann surfaces with flavor symmetry fluxes. This includes generalizations of super QCD with exceptional gauge groups and quarks replaced by 4D conformal matter. Just as in super QCD, we find evidence for a conformal window as well as confining gauge group factors depending on the total amount of matter. We also present F-theory realizations of these field theories via elliptically fibered Calabi-Yau fourfolds. Gauge groups (and flavor symmetries) come from 7-branes wrapped on surfaces, conformal matter localizes at the intersection of pairs of 7-branes, and Yukawas between 4D conformal matter localize at points coming from triple intersections of 7-branes. Quantum corrections can also modify the classical moduli space of the F-theory model, matching expectations from effective field theory.

  • Hagberg, Niklas
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Joelsson, M.
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Leonard, Dag
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Reid, Sarah
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Eloranta, Maija-Leena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Mo, J.
    AstraZeneca, Resp Inflammat & Autoimmun, IMED Biotech Unit, Gothenburg, Sweden.
    Nilsson, M.
    AstraZeneca, Resp Inflammat & Autoimmun, IMED Biotech Unit, Gothenburg, Sweden.
    Syvänen, Ann-Christine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Bryceson, Y. T.
    Karolinska Inst, Dept Med, Ctr Hematol & Regenerat Med, Karolinska Univ Hosp Huddinge, Stockholm, Sweden;Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE2018Inngår i: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 77, s. 668-668Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives Genetic variants in the transcription factor STAT4 are associated with increased susceptibility to systemic lupus erythematosus (SLE) and a more severe disease phenotype. This study aimed to clarify how the SLE-associated intronic STAT4 risk allele rs7574865[T] affects the function of immune cells in SLE. Methods Peripheral blood mononuclear cells (PBMCs) were isolated from 52 genotyped patients with SLE. Phosphorylation of STAT4 (pSTAT4) and STAT1 (pSTAT1) in response to interferon (IFN)-α, IFN-γ or interleukin (IL)-12, total levels of STAT4, STAT1 and T-bet, and frequency of IFN-γ+ cells on IL-12 stimulation were determined by flow cytometry in subsets of immune cells before and after preactivation of cells with phytohaemagglutinin (PHA) and IL-2. Cellular responses and phenotypes were correlated to STAT4 risk allele carriership. Janus kinase inhibitors (JAKi) selective for TYK2 (TYK2i) or JAK2 (JAK2i) were evaluated for inhibition of IL-12 or IFN-γ-induced activation of SLE PBMCs. Results In resting PBMCs, the STAT4 risk allele was neither associated with total levels of STAT4 or STAT1, nor cytokine-induced pSTAT4 or pSTAT1. Following PHA/IL-2 activation, CD8+ T cells from STAT4 risk allele carriers displayed increased levels of STAT4 resulting in increased pSTAT4 in response to IL-12 and IFN-α, and an augmented IL-12-induced IFN-γ production in CD8+ and CD4+ T cells. The TYK2i and the JAK2i efficiently blocked IL-12 and IFN-γ-induced activation of PBMCs from STAT4 risk patients, respectively. Conclusions T cells from patients with SLE carrying the STAT4 risk allele rs7574865[T] display an augmented response to IL-12 and IFN-α. This subset of patients may benefit from JAKi treatment.

  • Ye, Zou
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Challenges and Status of the ESSnuSB Accumulator Design2018Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    The 2.0 GeV, 5 MW proton linac for the European Spallation Source, ESS, will have the capacity to accelerate additional pulses, interleaved with the proton pulses for neutron production, and send them to a neutrino target, providing an excellent opportunity to produce an unprecedented high- performance neutrino beam, the ESS neutrino Super Beam (ESSnuSB), to measure, with precision, the CP violating phase at the 2nd oscillation maximum. In order to comply with the acceptance of the target and horn systems that will form the neutrino super beam, the long pulses from the linac must be compressed by about three orders of magnitude with minimal particle loss, something that will be achieved in an accumulator ring. This ring will accommodate about 1015 protons, which means that several design challenges are encountered. Strong space charge forces, low-loss injection, efficient collimation, and e-p instabilities are some of the aspects central to the design work. Different pulse structures and injection painting schemes have been studied, with the goal of mitigating space charge effects and of minimizing the heating of the stripping foil despite the very high beam intensity. This paper presents the status of the accumulator ring design, with multi- particle simulations of the injection procedure.

  • Hayashi, Masaki
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för speldesign.
    Bachelder, Steven
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för speldesign.
    Nakajima, Masayuki
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för speldesign.
    Automatic Generation of CG Animation from the Internet Forum "2 Channeru"2018Inngår i: Journal of the Institute of Image Information and Television Engineers, ISSN 1342-6907, Vol. 72, nr 10, s. 189-196Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [ja]

    Web サイトをはじめとする様々な情報をテレビ番組的なCG アニメーションに自動変換する研究開発を進めている.今回,その試みの一つとして,「2ちゃんねる掲示板」からコンピュータ・グラフィックス(CG) アニメーションを自動生成するアプリケーションを開発した.基本的な方法は,実際のテレビ番組映像を分析し,そこで使われている制作ノウハウを抽出して,これをルール化および数値化し,ソフトウェアに実装することで,テレビ番組を真似たCG アニメーションを得るというものである.今回,実際に放送された1 時間分の討論番組映像のカメラスイッチングを解析しアルゴリズム化した.本論文では,このプロセスの詳細を説明し,この方法により作成した実際のアプリケーションについて述べる.また,得られたCG アニメーションについて評価実験を行い,本手法の有効性と今後の課題を明らかにしたので,これについて述べる.

  • Lindgren, Karin Elvine
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Reproduktiv hälsa.
    Yaldir, Fatma Gulen
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Hreinsson, Julius
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, SE-14186 Stockholm, Sweden;Karolinska Univ Hosp, Unit Reprod Med, SE-14186 Stockholm, Sweden.
    Holte, Jan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Reproduktionsbiologi. Carl von Linne Clin, SE-75183 Uppsala, Sweden.
    Kårehed, Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Obstetrisk och reproduktiv hälsoforskning.
    Sundström Poromaa, Inger
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Reproduktiv hälsa.
    Kaihola, Helena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik.
    Åkerud, Helena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik.
    Differences in secretome in culture media when comparing blastocysts and arrested embryos using multiplex proximity assay2018Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, nr 3, s. 143-152Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: The aim of this study was to assess different patterns of the human embryo secretome analysed as protein levels in culture media. Furthermore, analyses to correlate protein levels with quality and timing to development of human embryos were performed.

    Material and methods: Human day-2 cryopreserved embryos were cultured for four days in an EmbryoScope((R)) with a time-lapse camera, and embryo quality was evaluated retrospectively. After culture, the media were collected and relative levels of secreted proteins were analysed using Proseek Multiplex Assays. Protein levels were evaluated in relation to timing to development and the ability to form a blastocyst.

    Results: Specific patterns of timing of development of blastocysts were found, where a difference in time to start of cavitation was found between high- and low-quality blastocysts. There appeared to be a correlation between specific protein patterns and successful formation of morulae and blastocysts. Embryos developing into blastocysts had higher levels of EMMPRIN than arrested embryos, and levels of caspase-3 were lower in high- versus low-quality blastocysts. Also, higher levels of VEGF-A, IL-6, and EMMPRIN correlated with shorter times to morula formation.

    Conclusions: The secretome and timing to development differ in embryos forming blastocysts and those that become arrested, and in high- versus low-quality blastocysts. The levels of certain proteins also correlate to specific times to development.

  • Zare, Reza
    et al.
    Vestre Viken HF Baerum Hosp, Dept Urol, Oslo, Norway.
    Grabe, Magnus
    Lund Univ, Skane Univ Hosp, Dept Urol, Malmo, Sweden.
    Hermann, Gregers G.
    Univ Copenhagen, Herlev & Gentofte Hosp, Dept Urol, Copenhagen, Denmark.
    Malmström, Per-Uno
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Urologkirurgi.
    Can routine outpatient follow-up of patients with bladder cancer be improved?: A multicenter prospective observational assessment of blue light flexible cystoscopy and fulguration2018Inngår i: Research and Reports in Urology, ISSN 2253-2447, E-ISSN 1179-1551, Vol. 10, s. 151-157Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The aim of this prospective cohort study was to determine the feasibility of incorporating blue light flexible cystoscopy (BLFC) and biopsy/fulguration into routine outpatient follow-up of non-muscle invasive bladder cancer patients.

    Methods: The study included patients with non-muscle-invasive bladder cancer (NMIBC) who were scheduled for routine follow-up. Hexaminolevulinate was instilled in the outpatient department, and the bladder was examined under white light and then with BLFC. Biopsies were taken from all suspicious lesions. Small tumors and suspicious lesions were fulgurated on site; patients with larger lesions were referred to the operating room for resection.

    Results: The study included 69 patients, with a mean age of 70 years (range 33 -89 years) and a mean duration since NMIBC diagnosis of 8 years. Most patients had high-grade cancer at initial diagnosis (52/69) and were at high risk of recurrence (48/69). Two patients per hour could be assessed using outpatient BLFC. Preparation and instillation of hexaminolevulinate took less than 10 minutes per patient, and patients had an additional waiting time of 45 60 minutes following instillation, while the hexaminolevulinate solution was retained in the bladder before examination. Eleven patients had histologically confirmed tumors that were identified using both white light flexible cystoscopy and BLFC. An additional three patients had tumors that were identified by BLFC only: two with Ta tumors and one with carcinoma in situ. Of the 14 patients with confirmed tumors, 11 could be managed on site with fulguration, whereas three were referred to the operating room. No adverse events attributable to BLFC were reported.

    Conclusion: Routine outpatient management of patients with NMIBC using BLFC and onsite biopsy/fulguration is feasible, despite the additional time required for hexaminolevulinate instillation, and appears to allow early detection of recurrent lesions, which can be fulgurated without the need for hospitalization.

  • Panda, Sunita
    et al.
    Trinity Coll Dublin, Sch Nursing & Midwifery, 2 Clare St, Dublin D02 CK80, Ireland.
    Daly, Deirdre
    Trinity Coll Dublin, Sch Nursing & Midwifery, 24 DOlier St, Dublin D02 T283, Ireland.
    Begley, Cecily
    Trinity Coll Dublin, Sch Nursing & Midwifery, 24 DOlier St, Dublin D02 T283, Ireland;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden.
    Karlstrom, Annika
    Mid Sweden Univ, Dept Nursing, S-86170 Sundsvall, Sweden.
    Larsson, Birgitta
    Mid Sweden Univ, Dept Nursing, S-86170 Sundsvall, Sweden.
    Back, Lena
    Mid Sweden Univ, Dept Nursing, S-86170 Sundsvall, Sweden.
    Hildingsson, Ingegerd
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Obstetrisk och reproduktiv hälsoforskning. Mid Sweden Univ, Dept Nursing, S-86170 Sundsvall, Sweden.
    Factors influencing decision-making for caesarean section in Sweden - a qualitative study2018Inngår i: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 18, artikkel-id 377Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Rising rates of caesarean section (CS) are a concern in many countries, yet Sweden has managed to maintain low CS rates. Exploring the multifactorial and complex reasons behind the rising trend in CS has become an important goal for health professionals. The aim of the study was to explore Swedish obstetricians' and midwives' perceptions of the factors influencing decision-making for CS in nulliparous women in Sweden. Methods: A qualitative design was chosen to gain in-depth understanding of the factors influencing the decision-making process for CS. Purposive sampling was used to select the participants. Four audio-recorded focus group interviews (FGIs), using an interview guide with open ended questions, were conducted with eleven midwives and five obstetricians from two selected Swedish maternity hospitals after obtaining written consent from each participant. Data were managed using NVivo (c) and thematically analysed. Ethical approval was granted by Trinity College Dublin. Results: The thematic analysis resulted in three main themes; 'Belief in normal birth - a cultural perspective'; 'Clarity and consistency - a system perspective' and 'Obstetrician makes the final decision, but ...', and each theme contained a number of subthemes. However, 'Belief in normal birth' emerged as the core central theme, overarching the other two themes. Conclusion: Findings suggest that believing that normal birth offers women and babies the best possible outcome contributes to having and maintaining a low CS rate. Both midwives and obstetricians agreed that having a shared belief (in normal birth), a common goal (of achieving normal birth) and providing mainly midwife-led care within a 'team approach' helped them achieve their goal and keep their CS rate low.

  • Munck-Kampmann, Birgit Elin
    et al.
    Werther, Inge
    Christensen, Lena Holm
    Policy Brief - Recycling in the Circular Economy: How to improve the recycling markets for construction materials, biowaste, plastics and critical metals2018Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    The objective of this report is to contribute to the development towards a Circular Economy and is based upon a number of Tema-Nord reports on recycling of vari-ous materials commissioned by the Nordic Council of Ministers. This report con-tains synthesized knowledge on metals, biomass, building materials and plastics, from projects completed for the Environment and Economy Group (MEG) and the Nordic Waste Group (NAG). The findings in the Tema-Nord reports are presented to demonstrate the potentials, barriers and policy instruments in relation to in-creased recycling and improvement of the markets for recycled resources. The target group of the report is decision makers and other stakeholders searching for circular economy inspiration and knowledge.

  • Ekstrand Ragnar, Maria
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Obstetrisk och reproduktiv hälsoforskning.
    Grandahl, Maria
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Obstetrisk och reproduktiv hälsoforskning.
    Stern, Jenny
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa. Sophiahemmet Univ, Dept Hlth Promoting Sci, Stockholm, Sweden.
    Mattebo, Magdalena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Obstetrisk och reproduktiv hälsoforskning. Malardalen Univ, Sch Hlth Care & Social Welf, Vasteras, Sweden.
    Important but far away: adolescents' beliefs, awareness and experiences of fertility and preconception health2018Inngår i: European journal of contraception & reproductive health care, ISSN 1362-5187, E-ISSN 1473-0782, Vol. 23, nr 4, s. 265-273Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: The aim was to explore adolescents' beliefs and awareness regarding fertility and preconception health, as well as their views and experiences of information about fertility and preconception health directed at their age group.

    Methods: We performed seven semi-structured focus group interviews among upper secondary school students (n = 47) aged 16-18 years in two Swedish counties. Data were analysed by qualitative content analysis.

    Results: One theme ('important but far away') and five categories ('starting a family far down on the list'; 'high awareness but patchy knowledge of fertility and preconception health'; 'gender roles influence beliefs about fertility and preconception health'; 'wish to preserve fertility and preconception health in order to keep the door to procreation open'; 'no panacea - early and continuous education about fertility and preconception health') emerged from the interviews. Participants recognised the importance of preconception health and were highly aware of the overall importance of a healthy lifestyle. Their knowledge, however, was patchy and they had difficulties relating to fertility and preconception health on a personal and behavioural level. Participants wanted more information but had heterogeneous beliefs about when, where and how this information should be given.

    Conclusion: The adolescents wanted information on fertility and preconception health to be delivered repeatedly as well as through different sources.

  • Choudhury, Sneha
    et al.
    Helmholtz Zentrum Berlin Mat & Energie GmbH, Inst Methods Mat Dev, Albert Einstein Str 15, D-12489 Berlin, Germany;Free Univ Berlin, Inst Chem & Biochem, Fabeckstr 36a, D-14195 Berlin, Germany.
    Kiendl, Benjamin
    Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany.
    Ren, Jian
    Helmholtz Zentrum Berlin Mat & Energie GmbH, Inst Methods Mat Dev, Albert Einstein Str 15, D-12489 Berlin, Germany;Free Univ Berlin, Dept Phys, Arnimallee 14, D-14195 Berlin, Germany.
    Gao, Fang
    Fraunhofer Inst Appl Solid State Phys IAF, Tullastr 72, D-79108 Freiburg, Germany;Max Planck Inst Mikrostrukturphys, Weinberg 2, D-06120 Halle, Germany.
    Knittel, Peter
    Fraunhofer Inst Appl Solid State Phys IAF, Tullastr 72, D-79108 Freiburg, Germany.
    Nebel, Christoph
    Fraunhofer Inst Appl Solid State Phys IAF, Tullastr 72, D-79108 Freiburg, Germany.
    Venerosy, Amelie
    CEA, LIST, Diamond Sensors Lab, F-91191 Gif Sur Yvette, France.
    Girard, Hugues
    CEA, LIST, Diamond Sensors Lab, F-91191 Gif Sur Yvette, France.
    Arnault, Jean-Charles
    CEA, LIST, Diamond Sensors Lab, F-91191 Gif Sur Yvette, France.
    Krueger, Anke
    Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany.
    Larsson, Karin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Oorganisk kemi.
    Petit, Tristan
    Helmholtz Zentrum Berlin Mat & Energie GmbH, Inst Methods Mat Dev, Albert Einstein Str 15, D-12489 Berlin, Germany.
    Combining nanostructuration with boron doping to alter sub band gap acceptor states in diamond materials2018Inngår i: Journal of Materials Chemistry A, ISSN 2050-7488, Vol. 6, nr 34, s. 16645-16654Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Diamond is a promising metal-free photocatalyst for nitrogen and carbon dioxide reduction in aqueous environment owing to the possibility of emitting highly reducing solvated electrons. However, the wide band gap of diamond necessitates the use of deep UV to trigger a photochemical reaction. Boron doping introduces acceptor levels within the band gap of diamonds, which may facilitate visible-light absorption through defect-based transitions. In this work, unoccupied electronic states from different boron-doped diamond materials, including single crystal, polycrystalline film, diamond foam, and nanodiamonds were probed by soft X-ray absorption spectroscopy at the carbon K edge. Supported by density functional theory calculations, we demonstrate that boron close to the surfaces of diamond crystallites induce acceptor levels in the band gap, which are dependent on the diamond morphology. Combining boron-doping with morphology engineering, this work thus demonstrates that electron acceptor states within the diamond band gap can be controlled.

  • Braun, Andreas P.
    et al.
    Univ Oxford, Math Inst, Woodstock Rd, Oxford OX2 6GG, England.
    Del Zotto, Michele
    SUNY Stony Brook, Simons Ctr Geometry & Phys, Stony Brook, NY 11794 USA.
    Halverson, James
    Northeastern Univ, Dept Phys, Boston, MA 02115 USA.
    Larfors, Magdalena
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik.
    Morrison, David R.
    Univ Calif Santa Barbara, Dept Math, Santa Barbara, CA 93106 USA.
    Schafer-Nameki, Sakura
    Univ Oxford, Math Inst, Woodstock Rd, Oxford OX2 6GG, England.
    Infinitely many M2-instanton corrections to M-theory on G(2)-manifolds2018Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 9, artikkel-id 077Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We consider the non-perturbative superpotential for a class of four-dimensional N = 1 vacua obtained from M-theory on seven-manifolds with holonomy G(2). The class of G(2)-holonomy manifolds we consider are so-called twisted connected sum (TCS) constructions, which have the topology of a K3-fibration over S-3. We show that the non-perturbative superpotential of M-theory on a class of TCS geometries receives infinitely many inequivalent M2-instanton contributions from infinitely many three-spheres, which we conjecture are supersymmetric (and thus associative) cycles. The rationale for our construction is provided by the duality chain of [1], which relates M-theory on TCS G(2) manifolds to E-8 x E-8 heterotic backgrounds on the Schoen Calabi-Yau threefold, as well as to F-theory on a K3-fibered Calabi-Yau fourfold. The latter are known to have an infinite number of instanton corrections to the superpotential and it is these contributions that we trace through the duality chain back to the G(2)-compactification.

  • Chiavassa, A.
    et al.
    Univ Cote dAzur, Observ Cote dAzur, CNRS, Lagrange, CS 34229, Nice, France.
    Freytag, Bernd
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk astrofysik.
    Schultheis, M.
    Univ Cote dAzur, Observ Cote dAzur, CNRS, Lagrange, CS 34229, Nice, France.
    Heading Gaia to measure atmospheric dynamics in AGB stars2018Inngår i: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 617, artikkel-id L1Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Context. Asymptotic giant branch (AGB) stars are characterised by complex stellar surface dynamics that affect the measurements and amplify the uncertainties on stellar parameters. The uncertainties in observed absolute magnitudes have been found to originate mainly from uncertainties in the parallaxes. The resulting motion of the stellar photocentre could have adverse effects on the parallax determination with Gaia. Aims. We explore the impact of the convection-related surface structure in AGBs on the photocentric variability. We quantify these effects to characterise the observed parallax errors and estimate fundamental stellar parameters and dynamical properties. Methods. We use three-dimensional (3D) radiative hydrodynamics simulations of convection with CO5BOLD and the post-processing radiative transfer code OPTIM3D to compute intensity maps in the Gaia G band [325-1030 nm]. From those maps, we calculate the intensity-weighted mean of all emitting points tiling the visible stellar surface (i.e. the photocentre) and evaluate its motion as a function of time. We extract the parallax error from Gaia data-release 2 (DR2) for a sample of semi-regular variables in the solar neighbourhood and compare it to the synthetic predictions of photocentre displacements. Results. AGB stars show a complex surface morphology characterised by the presence of few large-scale long-lived convective cells accompanied by short-lived and small-scale structures. As a consequence, the position of the photocentre displays temporal excursions between 0.077 and 0.198 AU (approximate to 5 to approximate to 11% of the corresponding stellar radius), depending on the simulation considered. We show that the convection-related variability accounts for a substantial part of the Gaia DR2 parallax error of our sample of semi-regular variables. Finally, we present evidence for a correlation between the mean photocentre displacement and the stellar fundamental parameters: surface gravity and pulsation. We suggest that parallax variations could be exploited quantitatively using appropriate radiation-hydrodynamics (RHD) simulations corresponding to the observed star.

  • Tamm-Hallström, Kristina
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Stockholms centrum för forskning om offentlig sektor (SCORE).
    Yngfalk, Carl
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Stockholms centrum för forskning om offentlig sektor (SCORE).
    Den KRAVfyllda handelsplatsen: Det vardagliga arbetet i en miljöcertifierad livsmedelsbutik2018Rapport (Annet vitenskapelig)
    Abstract [sv]

    Butikscertifiering utgör en växande trend inom detaljhandeln i Sverige och särskilt för livsmedelsbutiker. Till skillnad från certifiering och märkning av enskilda produkter som sedan 1990-talet utvecklats för att hjälpa konsumenter att välja ”rätt” enligt rådande miljönormer, berör butikscertifiering hela butiken som organisation. Genom en butikscertifiering ställs krav dels på butikens eget, direkta miljöansvar, dels på butikens påverkan på konsumenters förutsättningar att göra miljöanpassade val i handeln med livsmedel. Syftet med studien som redovisas här är att bidra med empiriskt grundad kunskap till den företagsekonomiska organisations- och marknadsföringsforskningen om standarder och certifiering som styrningsform för miljöarbete på marknader. Detta sker via en kvalitativ studie där ledning och personal i elva livsmedelsbutiker i Stockholmsområdet har intervjuats med fokus på deras arbete med KRAVs miljöstandard för butik. Den övergripande forskningsfrågan lyder Hur påverkar butikscertifiering organiseringen av butiken? Med organisering avses här vardagliga arbetsrutiner, lärande i organisationen och marknadsföring.

  • Junker, Svenne
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Stockholms centrum för forskning om offentlig sektor (SCORE).
    Yngfalk, Carl
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Stockholms centrum för forskning om offentlig sektor (SCORE).
    Vägen fram till beslutet om offentlig-privat samverkan för Nya Karolinska Solna2018Rapport (Annet vitenskapelig)
    Abstract [sv]

    I den här rapporten undersöks och diskuteras vägen fram till beslutet om att finansiera Nya Karolinska Solna (NKS) genom så kallad offentlig-privat samverkan (OPS). Fokus ligger på hur OPS-frågan utreddes efter maktskiftet i Stockholms läns landsting (SLL) 2006 fram till dess att fullmäktige i juni 2008 beslutade om en OPS-upphandling för byggande, ägande och drift av NKS.

  • Ivanov, Sergey
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik. Karpov Inst Phys Chem, Ctr Mat Sci, Vorontsovo Pole 10, Moscow Russia.
    Andersson, Mikael
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Cedervall, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Oorganisk kemi.
    Lewin, Erik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Oorganisk kemi.
    Sahlberg, Martin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Oorganisk kemi.
    Bazuev, G. V.
    Russian Acad Sci, Inst Solid State Chem, Ural Branch, Ekaterinburg 620990, Russia.
    Nordblad, Per
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Mathieu, Roland
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Temperature-dependent structural and magnetic properties of R2MMnO6 double perovskites (R=Dy, Gd; M=Ni, Co)2018Inngår i: Journal of materials science. Materials in electronics, ISSN 0957-4522, E-ISSN 1573-482X, Vol. 29, nr 21, s. 18581-18592Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The structural and magnetic properties of the Dy2CoMnO6, Dy2NiMnO6 and Gd2CoMnO6 double perovskites are investigated using X-ray powder diffraction and squid magnetometry. The materials adopt an orthorhombic structure (space ground Pnma) with disordered Co(Ni)/Mn cations, and exhibit ferrimagnetic transitions near T(C)85, 95, and 115K respectively. T-C was found to monotonously depend on the orthorhombic distortion (a-c)/(a+c) of the compounds. The crystal structure of the compounds was investigated as a function of temperature (16-1100K range), evidencing changes in the BO6 octahedron near T-C. The magnetic entropy changes are estimated for comparison of the magnetocaloric properties to those from literature.

  • Disputas: 2018-12-18 10:15 Planck, Fysikhuset, Linköping
    Lilja, Louise
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Halvledarmaterial. Linköpings universitet, Tekniska fakulteten.
    4H-SiC epitaxy investigating carrier lifetime and substrate off-axis dependence2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Silicon carbide (SiC) is a wide bandgap semiconductor with unique material properties making it useful for various device applications using high power, high frequency and high temperature. Compared to Si-based electronics, SiC based electronics have an improved energy efficiency. One of the most critical problems is to reduce this planets power consumption, where large improvements can be made enhancing the energy efficiency. Independent on how the electrical power is generated, power conversion is needed and about 10% of the electrical power is lost for every power conversion step using Si-based electronics. Since the efficiency is related to the performance of the semiconductor device, SiC can make contributions to the efficiency. Compared to Si, SiC has three times larger bandgap, about ten times higher breakdown electric field strength and about three times higher thermal conductivity. The wide bandgap together with the chemical stability of SiC makes it possible for SiC electronic devices to operate at much higher temperatures (>250°C) compared to Si-based devices and do not require large cooling units as with Si power converters.

    The current status for 4H-SiC devices regard unipolar devices (≤ 1700 V), such as metal-oxide-semiconductor field-effect transistors (MOSFETs) and Schottky barrier diodes (SBDs), are now on the market for mass production. The research focus is now on high-voltage (>10 kV) bipolar devices, such as, bipolar junction transistors (BJTs), p‑i‑n diodes and insulated-gate bipolar transistors (IGBTs).

    The focus of this thesis are material improvements relevant for the development of 4H-SiC high-voltage bipolar devices. A key parameter for such devices is the minority carrier lifetime, where long carrier lifetimes reduce the on-resistance through conductivity modulation. However, too long carrier lifetimes give long reverse recovery times leading to large switching losses. Thus, a tailored carrier lifetime is needed for the specific application. Carrier lifetimes of the epilayers can both be controlled by the CVD growth conditions and by post-growth processing, such as thermal oxidation and carbon implantation followed by thermal annealing. Emphasis in this thesis (Paper 1‑2) is to find optimal CVD growth conditions (growth temperature, C/Si ratio, growth rate, doping) improving the carrier lifetime. Since the main lifetime limiting defect has shown to be the Z1/2 center, identified as isolated carbon vacancies, growth conditions minimizing the Z1/2 concentration are strived for.

    To achieve high-voltage bipolar devices, thick epilayers of high quality is needed. An important factor is then the growth rate that needs to be relatively high in order to reduce the fabrication time, and thus the cost of the final device. In this thesis the growth process has been optimized for high growth rates (30 µm/h) using standard silane and propane chemistry (Paper 3), compared to other chemistries that includes chlorine, which results in corroded reactor parts and new defects in the epitaxial layers.

    Another important parameter for 4H-SiC bipolar devices is the basal plane dislocations (BPDs) in the substrate and epilayers, since the BPDs can act as source of nucleation and expansion of Shockley stacking faults (SSFs). The expanded SSFs give a lowered carrier lifetime and form a potential barrier for carrier transport leading to an increased forward voltage drop which in turn leads to bipolar degradation. The bipolar degradation is detrimental for 4H-SiC bipolar devices. Several strategies are developed to reduce the density of BPDs including buffer layers, growth interrupts and decreasing the substrates off-cut angle. Paper 4‑6 is focused on developing a CVD growth process for low substrate off-cut angles (1° and 2°) compared to the today’s standard off-cut angle of 4°. By reducing the substrate off-cut angle the number of BPDs intersecting the substrate surface is reduced. In addition, the conversion from BPDs to threading edge dislocations (TEDs) during epitaxial growth is increased with lower off-cut angles.

  • Röding, Magnus
    RISE - Research Institutes of Sweden, Biovetenskap och material, Jordbruk och livsmedel.
    Effective diffusivity in lattices of impermeable superballs2018Inngår i: Physical Review E. Statistical, Nonlinear, and Soft Matter Physics: Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics, ISSN 1063-651X, E-ISSN 1095-3787, Vol. 98, nr 5, artikkel-id 052908Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Granular materials constitute a broad class of two-phase media with discrete, solid par-ticles i.e. granules surrounded by a continuous void phase. They have properties that arekey for e.g. separation and chromatography columns, cathode materials for batteries, andpharmaceutical coatings for controlled release. Controlling mass transport properties suchas effective diffusivity is crucial for these applications and the subject of targeted designand optimization. The prototypical granule is a sphere, but current manufacturingtechniques allow for more complicated shapes to be produced in a highly controlled manner,including ellipsoids, cubes, and cubes with rounded edges and corners. The impactof shape for self-assembly, phase transitions, crystallization, and random close packing hasalso been studied for these shapes

  • Larsson, Håkan
    Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, Forskningsgruppen för pedagogisk idrottsforskning.
    Physical education - educating bodies after postmodernism?2018Inngår i: Educational Philosophy and Theory, ISSN 0013-1857, E-ISSN 1469-5812, Vol. 50, nr 14, s. 1435-1436Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The article offers the author's perspective about what comes after postmodernism and how it affects educational philosophy and theory, focusing on physical education (PE) in schools. The author argues that the adoption of the idea of performative pedagogies as a way to elicit social change also indicates adoption of movement. Education insights about bodies and embodiment from the case of Indian sprinter Dutee Chand are noted.

  • Gyllensvärd, Bo
    Rinkesta-tapeten: ett svenskt barockkineseri från 17331948Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1948, s. 101-114Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Mei, Xueshuang
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar. Peking Univ, Shenzhen Hosp, Dept Otolaryngol, Beijing, Peoples R China.
    Atturo, Francesca
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Wadin, Karin
    Uppsala Univ Hosp, Dept Diagnost Radiol, Uppsala, Sweden.
    Larsson, Sune
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Ortopedi.
    Agrawal, Sumit
    Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.
    Ladak, Hanif M.
    Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada;Western Univ, Dept Med Biophys, London, ON, Canada;Western Univ, Dept Elect & Comp Engn, London, ON, Canada.
    Li, Hao
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Rask-Andersen, Helge
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Human inner ear blood supply revisited: the Uppsala collection of temporal bone - an international resource of education and collaboration2018Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, nr 3, s. 131-142Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The Uppsala collection of human temporal bones and molds is a unique resource for education and international research collaboration. Micro-computerized tomography (micro-CT) and synchrotron imaging are used to investigate the complex anatomy of the inner ear. Impaired microcirculation is etiologically linked to various inner ear disorders, and recent developments in inner ear surgery promote examination of the vascular system. Here, for the first time, we present three-dimensional (3D) data from investigations of the major vascular pathways and corresponding bone channels.

    Methods: We used the archival Uppsala collection of temporal bones and molds consisting of 324 inner ear casts and 113 macerated temporal bones. Micro-CT was used to investigate vascular bone channels, and 26 fresh human temporal bones underwent synchrotron radiation phase contrast imaging (SR-PCI). Data were processed by volume-rendering software to create 3D reconstructions allowing orthogonal sectioning, cropping, and soft tissue analyses.

    Results: Micro-CT with 3D rendering was superior in reproducing the anatomy of the vascular bone channels, while SR-PCI replicated soft tissues. Arterial bone channels were traced from scala vestibuli (SV) arterioles to the fundus, cochlea, and vestibular apparatus. Drainage routes along the aqueducts were examined.

    Conclusion: Human inner ear vessels are difficult to study due to the adjoining hard bone. Micro-CT and SR-PCI with 3D reconstructions revealed large portions of the micro-vascular system in un-decalcified specimens. The results increase our understanding of the organization of the vascular system in humans and how altered microcirculation may relate to inner ear disorders. The findings may also have surgical implications.

  • Ekstrand, Gudrun
    Nordiska museet.
    En bruddräkt från 17441948Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1948, s. 93-100Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Sandelowsky, Hanna
    et al.
    Karolinska Inst, Sect Family Med & Primary Care, NVS, Stockholm, Sweden;Acad Primary Hlth Care Ctr, Stockholm, Sweden.
    Krakau, Ingvar
    Karolinska Inst, Sect Family Med & Primary Care, NVS, Stockholm, Sweden;Karolinska Inst, Dept Med, Div Clin Epidemiol, Stockholm, Sweden.
    Modin, Sonja
    Karolinska Inst, Sect Family Med & Primary Care, NVS, Stockholm, Sweden.
    Ställberg, Björn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Johansson, Sven-Erik
    Karolinska Inst, Sect Family Med & Primary Care, NVS, Stockholm, Sweden;Acad Primary Hlth Care Ctr, Stockholm, Sweden.
    Nager, Anna
    Karolinska Inst, Sect Family Med & Primary Care, NVS, Stockholm, Sweden.
    Effectiveness of traditional lectures and case methods in Swedish general practitioners' continuing medical education about COPD: a cluster randomised controlled trial2018Inngår i: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 8, nr 8, artikkel-id e021982Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: To study the effects of continuing medical education (CME) about chronic obstructive pulmonary disease (COPD) for general practitioners (GPs) by comparing two commonly used CME methods with each other and no CME (reference group).

    Design: A pragmatic cluster randomised controlled trial with primary healthcare centres (PHCCs) as units of randomisation.

    Setting, participants and interventions: 24 PHCCs in Stockholm County, Sweden, were randomised into two CME intervention arms: case method learning (CM) (n=12) and traditional lectures (TL) (n=12). A reference group without CME (n=11) was recruited separately. GPs (n=255) participated in the study arm to which their PHCC was allocated: CM, n=87; TL, n=93; and reference, n=75. Two 2-hour CME seminars were given in a period of 3 months.

    Primary outcome measures: Changes in scores between baseline and 12 months on a 13-item questionnaire about evidence-based COPD management (0-2 points/question, maximum total score 26 points).

    Results: 133 (52%) GPs completed the questionnaire both at baseline and 12 months. Both CM and TL resulted in small yet significantly higher total scores at 12 months than at baseline (CM, 10.34 vs 11.44; TL, 10.21 vs 10.91; p<0.05); there were few significant differences between these CME methods. At both baseline and 12 months, all three groups' scores were generally high on questions about smoking cessation support and low on those that measured spirometry interpretation skills, interprofessional care and management of multimorbidity.

    Conclusions: Neither short CM nor short TL CME sessions substantially improve GPs' skills in managing COPD. It is justified to challenge the use of these common CME methods as a strategy for improving GPs' level of knowledge about management of COPD and other complex chronic diseases characterised by multimorbidity. Trial registration number NCT02213809

  • Wallin, Sigurd
    Nordiska museet.
    Carin Sylvander tecknar 1800-tal1948Inngår i: Fataburen, Stockholm: Nordiska museets förlag, 1948, s. 77-92Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Johansen, Trond Cato
    et al.
    Ramböll.
    Fors, Carina
    Statens väg- och transportforskningsinstitut, Trafik och trafikant,TRAF, Trafikanttillstånd, TIL.
    Nordic certification of road marking materials in Norway and Sweden 2016–20182018Rapport (Annet vitenskapelig)
    Abstract [en]

    A Nordic certification system for road marking materials, that applies to the countries of Denmark, Norway and Sweden, was introduced in 2015. In these countries, a documented product approval is required in order to use a road marking material on roads managed by the national road authorities. Product approval is based on monitored and documented performance measurements of material samples applied on test fields on public roads.

    A Norwegian-Swedish test site was established in 2015, where between 43 and 81 materials have been applied yearly. The applied materials are followed up with performance measurements for two years. The materials are approved (certified) in relation to the number of wheel passages they will stand.

    The certification system includes road marking materials for longitudinal road markings in categories with respect to colour (white, yellow), type (type I, type II, antiskid) and thickness (0.4, 0.6, 1.5, 3 and 4 mm).

    The present report documents the follow-up performance measurements that were carried out at the Norwegian-Swedish test site in 2018, i.e. one-year follow-up measurements for materials applied in 2017 and two years follow-up measurements for materials applied in 2016. The performance parameters include the coefficient of retroreflected luminance (RL) under dry and wet conditions, the luminance coefficient under diffuse illumination (Qd), the friction, the chromaticity in daylight, and the chromaticity of retroreflected light (yellow materials, only).

  • Tistad, Malin
    et al.
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat Therapy, Huddinge, Sweden;Dalarna Univ, Sch Educ Hlth & Social Studies, Falun, Sweden;Umea Univ, Dept Rehabil & Social Med, Physiotherapy, Umea, Sweden.
    Flink, Maria
    Karolinska Univ Hosp, Funct Area Social Work Hlth, Stockholm, Sweden;Karolinska Inst, Dept Learning Informat Management & Eth, Stockholm, Sweden.
    Ytterberg, Charlotte
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Physiotherapy, Huddinge, Sweden;Karolinska Univ Hosp, Funct Area Occupat Therapy & Physiotherapy, Stockholm, Sweden.
    Eriksson, Gunilla
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Rehabiliteringsmedicin. Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat Therapy, Huddinge, Sweden.
    Guidetti, Susanne
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat Therapy, Huddinge, Sweden.
    Tham, Kerstin
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat Therapy, Huddinge, Sweden;Malmo Univ, Fac Hlth & Soc, Malmo, Sweden.
    von Koch, Lena
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat Therapy, Huddinge, Sweden;Karolinska Univ Hosp, Theme Neuro, Stockholm, Sweden.
    Resource use of healthcare services 1 year after stroke: a secondary analysis of a cluster-randomised controlled trial of a client-centred activities of daily living intervention2018Inngår i: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 8, nr 8, artikkel-id e022222Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: The objective of the study was to compare the total use of healthcare services in the course of the first year after a stroke between participants who, after the acute care, had received occupational therapy as a client-centred activities of daily living (ADL) intervention (CADL) and participants who had received usual ADL intervention (UADL).

    Design: A secondary analysis of a multicentre cluster-randomised controlled trial (RCT).

    Setting: Primary and secondary care in Sweden.

    Participants: Participants were included if they: (1) had received CADL or UADL in the RCT, either as inpatients in geriatric rehabilitation units or in their own homes, and (2) data could be retrieved about their use of healthcare services provided by the county council from computerised registers.

    Interventions: CADL or UADL.

    Outcome measures: Inpatient and outpatient healthcare in the course of the first year after stroke.

    Results: Participants from 7 of the 16 units included in the RCT met the criteria. Participants in the CADL group (n=26) who received geriatric inpatient rehabilitation had a shorter length of hospital stay (p=0.03) than participants in the UADL group (n=46), and the CADL group with home rehabilitation (n=13) had fewer outpatient contacts (p=0.01) compared with the UADL group (n=25). Multiple regression analyses showed that in four of the models, a higher age was associated with a lower use of healthcare services. The use of healthcare services was also associated (some of the models) with dependence in ADL, stroke severity and type of rehabilitation received, CADL or UADL.

    Conclusions: The provision of client-centred occupational therapy after stroke did not appear to increase the use of healthcare services during the first year after stroke. Trial registration number NCT01417585.

  • Johansen, Trond Cato
    et al.
    Ramböll.
    Fors, Carina
    Statens väg- och transportforskningsinstitut, Trafik och trafikant,TRAF, Trafikanttillstånd, TIL.
    Nordic certification of road marking materials in Denmark 2016–20182018Rapport (Annet vitenskapelig)
    Abstract [en]

    A Nordic certification system for road marking materials, that applies to the countries of Denmark, Norway and Sweden, was introduced in 2015. In these countries, a documented product approval is required in order to use a road marking material on roads managed by the national road authorities. Product approval is based on monitored and documented performance measurements of material samples applied on test fields on public roads.

    A Danish test site was established in 2015, where between 13 and 32 materials have been applied yearly. The applied materials are followed up with performance measurements for two years. The materials are approved (certified) in relation to the number of wheel passages they will stand.

    The certification system includes road marking materials for longitudinal road markings in categories with respect to colour (white, yellow), type (type I, type II, antiskid) and thickness (0.4, 0.6, 1.5, 3 and 4 mm).

    The present report documents the follow-up performance measurements that were carried out at the Danish test site in 2018, i.e. one-year follow-up measurements for materials applied in 2017 and two years follow-up measurements for materials applied in 2016. The performance parameters include the coefficient of retroreflected luminance (RL) under dry and wet conditions, the luminance coefficient under diffuse illumination (Qd), the friction, and the chromaticity in daylight.

  • Lundwall, Sten
    Nordiska museet.
    Karl-Erik Forsslund, Skansen och storgården1948Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1948, s. 67-76Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Wright, Alison E.
    et al.
    Univ Sheffield, Dept Anim & Plant Sci, Sheffield, S Yorkshire, England.
    Fumagalli, Matteo
    Imperial Coll London, Dept Life Sci, Silwood Pk Campus, London, England.
    Cooney, Christopher R.
    Univ Sheffield, Dept Anim & Plant Sci, Sheffield, S Yorkshire, England.
    Bloch, Natasha, I
    UCL, Dept Genet Evolut & Environm, London, England.
    Vieira, Filipe G.
    Univ Copenhagen, Ctr GeoGenet, Nat Hist Museum Denmark, Copenhagen, Denmark.
    Buechel, Severine D.
    Stockholm Univ, Dept Zool, Stockholm, Sweden.
    Kolm, Niclas
    Stockholm Univ, Dept Zool, Stockholm, Sweden.
    Mank, Judith E.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Systematisk biologi. UCL, Dept Genet Evolut & Environm, London, England.
    Male-biased gene expression resolves sexual conflict through the evolution of sex-specific genetic architecture2018Inngår i: EVOLUTION LETTERS, ISSN 2056-3744, Vol. 2, nr 2, s. 52-61Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Many genes are subject to contradictory selection pressures in males and females, and balancing selection resulting from sexual conflict has the potential to substantially increase standing genetic diversity in populations and thereby act as an important force in adaptation. However, the underlying causes of sexual conflict, and the potential for resolution, remains hotly debated. Using transcriptome-resequencing data from male and female guppies, we use a novel approach, combining patterns of genetic diversity and intersexual divergence in allele frequency, to distinguish the different scenarios that give rise to sexual conflict, and how this conflict may be resolved through regulatory evolution. We show that reproductive fitness is the main source of sexual conflict, and this is resolved via the evolution of male-biased expression. Furthermore, resolution of sexual conflict produces significant differences in genetic architecture between males and females, which in turn lead to specific alleles influencing sex-specific viability. Together, our findings suggest an important role for sexual conflict in shaping broad patterns of genome diversity, and show that regulatory evolution is a rapid and efficient route to the resolution of conflict.

  • Hazelius-Berg, Gunnel
    Nordiska museet.
    Beata Jaquette Ribbings mönstersamling1948Inngår i: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1948, s. 49-66Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Parker, James
    et al.
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Rydberglaboratoriet för tillämpad naturvetenskap (RLAS). Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI).
    Lundgren, Lina
    Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, Rydberglaboratoriet för tillämpad naturvetenskap (RLAS). Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), CAISR Centrum för tillämpade intelligenta system (IS-lab).
    Surfing the Waves of the CMJ: Are There between-Sport Differences in the Waveform Data?2018Inngår i: Sports, E-ISSN 2075-4663, Vol. 6, nr 4, s. 1-12, artikkel-id 168Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The ability to analyse countermovement jump (CMJ) waveform data using statistical methods, like principal component analysis, can provide additional information regarding the different phases of the CMJ, compared to jump height or peak power alone. The aim of this study was to investigate the between-sport force-time curve differences in the CMJ. Eighteen high level golfers (male = 10, female = 8) and eighteen high level surfers (male = 10, female = 8) performed three separate countermovement jumps on a force platform. Time series of data from the force platform was normalized to body weight and each repetition was then normalized to 0–100 percent. Principal component analyses (PCA) were performed on force waveforms and the first six PCs explained 35% of the variance in force parameters. The main features of the movement cycles were characterized by magnitude (PC1 and PC5), waveform (PC2 and PC4), and phase shift features (PC3). Surf athletes differ in their CMJ technique and show a greater negative centre of mass displacement when compared to golfers (PC1), although these differences are not necessarily associated with greater jump height. Principal component 5 demonstrated the largest correlation with jump height (R2  = 0.52). Further studies are recommended in this area, to reveal which features of the CMJ thatrelate to jumping performance, and sport specific adaptations. © 2018 by the authors.

  • Disputas: 2019-01-22 10:00 U61, Stockholm
    Bekele, Abiy
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Byggvetenskap, Byggnadsmaterial.
    Application of Automated Non-contact Resonance Testing for Low Temperature Behavior of Asphalt Concrete2019Licentiatavhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Impact resonance testing is a well-documented non-destructive testing method and its applications on asphalt concrete have also been implemented successfully. The test is carried out manually by inducing an impact in order to excite the test specimen and taking measurements of the vibrational response. In an effort to improve the manual procedure of impact resonance testing, an automated non-contact methodology is developed and its applicability with regards to low temperature behaviors of asphalt concrete is investigated. Results from this work show that repeatable fundamental resonance frequency measurements can be performed on a disc shaped specimen in an automated manner without the need to open the thermal chamber. The measurements obtained from the new method have been verified by taking similar resonance frequency measurements using an instrumented impact hammer. It has also been shown in this work that the proposed method is suitable to investigate the lone effects of cyclic thermal conditioning on asphalt concrete without any other possible biasing effects associated with contact in the conventional testing. A hysteretic behavior of stiffness modulus is obtained on three different asphalt concrete specimens subjected to repeated low temperature cyclic conditioning. Reduced modulus values at each temperature are obtained in all the tested specimens after a low temperature stepwise conditioning at temperatures from 0oC to -40 oC. This observed behavior shows that the dynamic modulus of the tested specimens is affected by low temperature conditioning. The norm of the complex modulus decreases and the phase angle or damping ratio increases after low temperature conditioning. Hence, valuable and practical low temperature characteristics of different asphalt concrete mixtures can possibly be obtained by using the proposed methodology.

  • Dahlström, Helene
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för utbildningsvetenskap.
    Digital writing tools from the student perspective: Access, affordances, and agency2018Inngår i: Education and Information Technologies: Official Journal of the IFIP technical committee on Education, ISSN 1360-2357, E-ISSN 1573-7608Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Along with digital development, new possibilities for communicating have emerged. The younger generation has adopted these new possibilities to a great extent. In order to be able to utilise the opportunities offered by digital tools when writing, access to digital tools is essential. Schools need to develop a writing education that meets students’ contemporary writing needs. In considering this, it is important to learn more about the gains and the losses in digital writing. The purpose of this study was to understand and discuss the relation between students’ digital access, students’ per- ceived affordances with digital writing, and student agency. The methods used were a statistical survey and qualitative interviews. Six classes from five different schools located in a municipality in the middle of Sweden were chosen as an informant group. The results indicate that the most common condition concerning students’ digital access was that students shared digital tools for writing with their families. An analysis of affordances was carried out to interpret the empirical findings from the qualitative data. Affordances that emerged were: write-ability, edit-ability, story-telling ability and accessibility. In addition, the ways in which digital access and the affordances per- ceived can be related to student agency were analysed. The main conclusion was that given the conditions of digital access and opportunities to practice, the affordances of digital writing can increase student agency. In turn, this suggests that writing education that focuses on student agency can contribute to equity in writing activities.

  • Fu, Zhirong
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi.
    Thorpe, Michael
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi.
    Akula, Srinivas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi.
    Chahal, Gurdeep
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi.
    Hellman, Lars
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi.
    Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability2018Inngår i: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 9, artikkel-id 2387Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Serine proteases are major granule constituents of several of the human hematopoietic cell lineages. Four proteolytically active such proteases have been identified in human neutrophils: cathepsin G (hCG), N-elastase (hNE), proteinase 3 (hPR-3), and neutrophil serine protease 4 (hNSP-4). Here we present the extended cleavage specificity of two of the most potent and most abundant of these enzymes, hNE and hPR-3. Their extended specificities were determined by phage display and by the analysis of a panel of chromogenic and recombinant substrates. hNE is an elastase with a relatively broad specificity showing a preference for regions containing several aliphatic amino acids. The protease shows self-cleaving activity, which results in the loss of activity during storage even at +4 degrees C. Here we also present the extended cleavage specificity of hPR-3. Compared with hNE, it shows considerably lower proteolytic activity. However, it is very stable, shows no self-cleaving activity and is actually more active in the presence of SDS, possibly by enhancing the accessibility of the target substrate. This enables specific analysis of hPR-3 activity even in the presence of all the other neutrophil enzymes with addition of 1% SDS. Neutrophils are the most abundant white blood cell in humans and one of the key players in our innate immune defense. The neutrophil serine proteases are very important for the function of the neutrophils and therefore also interesting from an evolutionary perspective. In order to study the origin and functional conservation of these neutrophil proteases we have identified and cloned an amphibian ortholog, Xenopus PR-3 (xPR-3). This enzyme was found to have a specificity very similar to hPR-3 but did not show the high stability in the presence of SDS. The presence of an elastase in Xenopus closely related to hPR-3 indicates a relatively early appearance of these enzymes during vertebrate evolution.

  • Lissbrant, Ingela Franck
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden.
    Ventimiglia, Eugenio
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Urologkirurgi. Osped San Raffaele, IRCCS, URI, Div Expt Oncol, Unit Urol, Milan, Italy.
    Robinson, David
    Ryhov Cty Hosp, Dept Urol, Jönköping, Sweden.
    Törnblom, Magnus
    Visby Cty Hosp, Dept Surg, Visby, Sweden.
    Hjalm-Eriksson, Marie
    Capio St Gorans Hosp, Dept Surg, Stockholm, Sweden; Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
    Lambe, Mats
    Uppsala Univ Hosp, Reg Canc Ctr, Uppsala, Sweden.
    Folkvaljon, Yasin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Urologkirurgi.
    Stattin, Pär
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Urologkirurgi.
    Nationwide population-based study on the use of novel antiandrogens in men with prostate cancer in Sweden2018Inngår i: Scandinavian journal of urology, ISSN 2168-1805, E-ISSN 2168-1813, Vol. 52, nr 2, s. 143-150Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: The aim of this study was to examine the use of abiraterone and enzalutamide, two oral novel antiandrogens (NOVAs), in men with prostate cancer (PCa) in Sweden.

    Materials and methods: This cross-sectional study investigated filled prescriptions for NOVAs recorded in the Swedish Prescribed Drug Register between July 2015 and April 2016. Associations between age, comorbidity, educational level, marital status and county of residence and filled prescriptions were analyzed in the National Prostate Cancer Register (NPCR) and other health population-based registers, using multivariable logistic regression.

    Results: Of 91,209 men, 1650 (2%) had at least one prescription filled for NOVAs, of whom 1350 (82%) had high-risk or metastatic PCa at diagnosis.. Of 1914 men with M1 disease and a high probability of castration-resistant prostate cancer (CRPC), 22% had a prescription for NOVAs at a median 3 years after the date of diagnosis. At multivariable logistic regression analysis,, the likelihood of NOVA use was lower in older men [age >80 vs <70 years: odds ratio (OR) 0.23, 95% confidence interval (CI) 0.15–0.35] and in men with lower educational level (high vs low education: OR 1.64, 95% CI 1.23–2.20). There was up to a five-fold difference in the use of NOVAs between county councils.

    Conclusions: Less than one-third of potentially eligible men with CRPC received NOVAs in 2015–2016. There were large differences in use according to age and region of residence, indicating that efforts are needed to improve equal access to novel cancer drugs.

  • Aaboud, M.
    et al.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Brenner, Richard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Öhman, Henrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Rangel Smith, Camila
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Zwalinski, L.
    Measurement of jet fragmentation in 5.02 TeV proton-lead and proton-proton collisions with the ATLAS detector2018Inngår i: Nuclear Physics A, ISSN 0375-9474, E-ISSN 1873-1554, Vol. 978, s. 65-106Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A measurement of the fragmentation functions of jets into charged particles in p Pb collisions and pp collisions is presented. The analysis utilizes 28 nb(-1) of p Pb data and 26 pb(-1) of pp data, both at root(TN)-T-s= 5.02 TeV, collected in 2013 and 2015, respectively, with the ATLAS detector at the LHC. The measurement is reported in the centre-of-mass frame of the nucleon-nucleon system for jets in the rapidity range vertical bar y*vertical bar <1.6 and with transverse momentum 45 < p(T) < 260 GeV. Results are presented both as a function of the charged-particle transverse momentum and as a function of the longitudinal momentum fraction of the particle with respect to the jet. The pp fragmentation functions are compared with results from Monte Carlo event generators and two theoretical models. The ratios of the p +Pb to pp fragmentation functions are found to be consistent with unity.

  • Bergsten, Johannes
    et al.
    Naturhistoriska riksmuseet, Enheten för zoologi.
    Göthberg, Anders
    Johansson, Karolina
    Pettersson, Arne
    Burkart, Werner
    Burkart, Gudrun
    Entomologmötet på Gotland 2017: temaexkursion med fokus på vattenlevande skalbaggar, skinnbaggar och trollsländor i Äskåkersvät.2017Inngår i: Entomologisk Tidskrift, ISSN 0013-886X, Vol. 139, nr 1, s. 39-49Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The yearly Swedish entomology meeting 2017 was organized by the local entomology

    society of Gotland, on the northern part of the Baltic island Gotland near Bunge, 4-6 August.

    One thematic excursion was focused on aquatic insects, especiallly aquatic beetles,

    bugs and dragonflies. A shallow pond, Äskåkersvät, with Characeae in an open grazed

    landscape with high natural values was studied. Äskåkersvät lies just adjacent to the larger

    area around lake Bästeträsk which is the focus of a pilot study evaluating its potential as

    a future national park. The pilot study is undertaken by Gotland County Administrative

    Board, the Swedish Environmental Protection Agency, Region Gotland and the Swedish

    Agency for Marine and Water Management. Here we give an annotated report of the 103

    species found: 69 species of water beetles (out of which 34 were Dytiscidae), 20 species

    of aquatic or semiaquatic bugs (out of which 10 were Corixidae), and 14 species of dragonflies.

    These include Hydrophilus piceus and H. aterrimus redlisted in Sweden (both as

    NT), and Dytiscus latissimus, globally redlisted (VU). We also noted the noble crayfish,

    Astacus astacus (redlisted as CR in Sweden) and the European medicinal leech Hirudo

    medicinalis (redlisted as NT globally). The blue emperor dragonfly (Anax imperator) was

    noted, a species first recorded from Gotland in 2002 and we present a graph on its increase

    and spreading on the island since. The number of species found in spite of a relatively

    modest collecting effort at a suboptimal time when many species may be in pupal stage out

    of water as witnessed by many teneral individuals, indicates a species rich locality with

    high natural value. The stoneworts (Characeae) vegetation certainly contributes to this, for

    instance vouched for by the occurrence of specialists as Haliplus confinis and H. obliquus

    whose larvae feed on stoneworts.

  • Nikolaidou, Zoe
    et al.
    Bellander, Theres
    Stockholms universitet, Humanistiska fakulteten, Institutionen för svenska och flerspråkighet, Svenska/Nordiska språk.
    Health literacy as knowledge construction: Learning about health by expanding objects and crossing boundaries in networked activities2018Inngår i: Learning, Culture and Social Interaction, ISSN 2210-6561, E-ISSN 2210-657XArtikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this paper we examine health literacy as a set of practices that unfold in networked activity systems. Focusing on the literacy practices of pregnant couples and parents of children with heart defect, we show that they participate in multiple activities with the object of constructing knowledge about the child's condition. The contexts for these activities are doctor-patient con- sultations and the parents' online searching and sharing. The study builds on ethnographic in- terviews, recorded medical consultations and collection of texts from online forums, blogs and social media. An analysis based on literacy practices and activity theory shows that these ac- tivities enable parents' learning, but they can also be restricting as to the mediating tools they provide and the rules that dictate the tools. Additionally, the object of learning about heart defect is not always clearly formulated and stable but it keeps alternating and expanding. As a result, the parents cross boundaries between activities with different mediating tools, rules and com- munities and thereby different possibilities for learning. We show that doing health literacy is comprised by a set of recontextualised practices of looking for medical and experiential knowl- edge and it is by a combination of the two that meaningful learning is achieved.

  • Sundberg, Henrik
    et al.
    Kruys, Åsa
    Bergsten, Johannes
    Naturhistoriska riksmuseet, Enheten för zoologi.
    Ekman, Stefan
    Position specificity in the genus Coreomyces (Laboulbeniomycetes, Ascomycota)2018Inngår i: Fungal Systematics and Evolution, ISSN 2589-3823, Vol. 1, s. 217-228Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    To study position specificity in the insect-parasitic fungal genus Coreomyces (Laboulbeniaceae, Laboulbeniales),

    we sampled corixid hosts (Corixidae, Heteroptera) in southern Scandinavia. We detected Coreomyces thalli in five different

    positions on the hosts. Thalli from the various positions grouped in four distinct clusters in the resulting gene trees, distinctly

    so in the ITS and LSU of the nuclear ribosomal DNA, less so in the SSU of the nuclear ribosomal DNA and the mitochondrial

    ribosomal DNA. Thalli from the left side of abdomen grouped in a single cluster, and so did thalli from the ventral right side.

    Thalli in the mid-ventral position turned out to be a mix of three clades, while thalli growing dorsally grouped with thalli from

    the left and right abdominal clades. The mid-ventral and dorsal positions were found in male hosts only. The position on the left

    hemelytron was shared by members from two sister clades. Statistical analyses demonstrate a significant positive correlation

    between clade and position on the host, but also a weak correlation between host sex and clade membership. These results

    indicate that sex-of-host specificity may be a non-existent extreme in a continuum, where instead weak preferences for one

    host sex may turn out to be frequent.

  • Désamorè, Aurélie
    et al.
    Naturhistoriska riksmuseet, Enheten för zoologi.
    Laenen, Benjamin
    Miller, Kelly
    University of New Mexico.
    Bergsten, Johannes
    Naturhistoriska riksmuseet, Enheten för zoologi.
    Early burst in body size evolution is uncoupled from species diversification in diving beetles (Dytiscidae)2018Inngår i: Molecular Ecology, ISSN 0962-1083, E-ISSN 1365-294X, Vol. 27, nr 4, s. 979-993Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Changes in morphology are often thought to be linked to changes in species diversification,

    which is expected to leave a signal of early burst (EB) in phenotypic traits.

    However, such signal is rarely recovered in empirical phylogenies, even for groups

    with well-known adaptive radiation. Using a comprehensive phylogenetic approach

    in Dytiscidae, which harbours ~4,300 species with as much as 50-fold variation in

    body size among them, we ask whether pattern of species diversification correlates

    with morphological evolution. Additionally, we test whether the large variation in

    body size is linked to habitat preference and whether the latter influences species

    turnover. We found, in sharp contrast to most animal groups, that Dytiscidae body

    size evolution follows an early-burst model with subsequent high phylogenetic conservatism.

    However, we found no evidence for associated shifts in species diversification,

    which point to an uncoupled evolution of morphology and species

    diversification. We recovered the ancestral habitat of Dytiscidae as lentic (standing

    water), with many transitions to lotic habitat (running water) that are concomitant

    to a decrease in body size. Finally, we found no evidence for difference in net diversification

    rates between habitats nor difference in turnover in lentic and lotic species.

    This result, together with recent findings in dragonflies, contrasts with some

    theoretical expectations of the habitat stability hypothesis. Thus, a thorough

    reassessment of the impact of dispersal, gene flow and range size on the speciation

    process is needed to fully encompass the evolutionary consequences of the lentic–

    lotic divide for freshwater fauna.

  • Chiavaroli, Valentina
    et al.
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Hopkins, Sarah A.
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Derraik, Jose G. B.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa. Univ Auckland, Liggins Inst, Auckland, New Zealand;Univ Auckland, A Better Start Natl Sci Challenge, Auckland, New Zealand.
    Biggs, Janene B.
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Rodrigues, Raquel O.
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Brennan, Christine H.
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Seneviratne, Sumudu N.
    Univ Auckland, Liggins Inst, Auckland, New Zealand;Univ Colombo, Dept Paediat, Fac Med, Colombo, Sri Lanka.
    Higgins, Chelsea
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Baldi, James C.
    Univ Otago, Dunedin Sch Med, Dept Med, Dunedin, New Zealand.
    McCowan, Lesley M. E.
    Univ Auckland, Dept Obstet & Gynaecol, Fac Med & Hlth Sci, Auckland, New Zealand.
    Cutfield, Wayne S.
    Univ Auckland, Liggins Inst, Auckland, New Zealand;Univ Auckland, A Better Start Natl Sci Challenge, Auckland, New Zealand.
    Hofman, Paul L.
    Univ Auckland, Liggins Inst, Auckland, New Zealand.
    Exercise in pregnancy: 1-year and 7-year follow-ups of mothers and offspring after a randomized controlled trial2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 12915Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    There are limited data on long-term outcomes of mothers or their offspring following exercise interventions during pregnancy. We assessed long-term effects of an exercise intervention (home-based stationary cycling) between 20-36 weeks of gestation on anthropometry and body composition in mothers and offspring after 1 and 7 years. 84 women were randomised to intervention or usual activity, with follow-up data available for 61 mother-child pairs (38 exercisers) at 1 year and 57 (33 exercisers) at 7 years. At 1 year, there were no observed differences in measured outcomes between mothers and offspring in the two groups. At the 7-year follow-up, mothers were mostly similar, except that exercisers had lower systolic blood pressure (-6.2 mmHg; p = 0.049). However, offspring of mothers who exercised during pregnancy had increased total body fat (+3.2%; p = 0.034) and greater abdominal (+4.1% android fat; p = 0.040) and gynoid (+3.5% gynoid fat; p = 0.042) adiposity compared with controls. Exercise interventions beginning during pregnancy may be beneficial to long-term maternal health. However, the initiation of exercise during pregnancy amongst sedentary mothers may be associated with adverse effects in the offspring during childhood. Larger follow-up studies are required to investigate long-term effects of exercise in pregnancy.

  • Aharony, Ofer
    et al.
    Weizmann Inst Sci, Dept Particle Phys & Astrophys, IL-7610001 Rehovot, Israel.
    Alday, Luis F.
    Univ Oxford, Math Inst, Radcliffe Observ Quarter, Andrew Wiles Bldg,Woodstock Rd, Oxford OX2 6GG, England.
    Bissi, Agnese
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik.
    Yacoby, Ran
    Weizmann Inst Sci, Dept Particle Phys & Astrophys, IL-7610001 Rehovot, Israel.
    The analytic bootstrap for large N Chern-Simons vector models2018Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 8, artikkel-id 166Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Three-dimensional Chern-Simons vector models display an approximate higher spin symmetry in the large N limit. Their single-trace operators consist of a tower of weakly broken currents, as well as a scalar a of approximate twist 1 or 2. We study the consequences of crossing symmetry for the four-point correlator of a in a 1/N expansion, using analytic bootstrap techniques. To order 1/N we show that crossing symmetry fixes the contribution from the tower of currents, providing an alternative derivation of well-known results by Maldacena and Zhiboedov. When sigma has twist 1 its OPE receives a contribution from the exchange of a itself with an arbitrary coefficient, due to the existence of a marginal sextic coupling. We develop the machinery to determine the corrections to the OPE data of double-trace operators due to this, and to similar exchanges. This in turns allows us to fix completely the correlator up to three known truncated solutions to crossing. We then proceed to study the problem to order 1/N-2. We find that crossing implies the appearance of odd-twist double-trace operators, and calculate their OPE coefficients in a large spin expansion. Also, surprisingly, crossing at order 1/N-2, implies non-trivial O(1/N) anomalous dimensions for even-twist double-trace operators, even though such contributions do not appear in the four-point function at order 1/N (in the case where there is no scalar exchange). We argue that this phenomenon arises due to operator mixing. Finally, we analyse the bosonic vector model with a sextic coupling without gauge interactions, and determine the order 1/N-2 corrections to the dimensions of twist-2 double-trace operators.

  • Sun, Xiaole
    et al.
    Stockholm University.
    Mörth, Carl-Magnus
    Stockholm University.
    Porcelli, Don
    Oxford University.
    Kutscher, Liselott
    Naturhistoriska riksmuseet, Enheten för geovetenskap.
    Hirst, Catherine
    Naturhistoriska riksmuseet, Enheten för geovetenskap.
    Murphy, Melissa
    Oxford University.
    Maximov, Trofim
    Institute for Biological Problems in the Cryolithozone, Yakusk.
    Petrov, Roman
    Institute for Natural Sciences of North Federal University, Yakutsk.
    Humborg, Christoph
    Stockholm University.
    Schmitt, Melanie
    Naturhistoriska riksmuseet, Enheten för geovetenskap.
    Andersson, Per
    Naturhistoriska riksmuseet, Enheten för geovetenskap.
    Stable Silicon Isotopic Compositions of the Lena River and its Tributaries: Implications for Silicon Delivery to the Arctic Ocean2018Inngår i: Geochimica et Cosmochimica Acta, ISSN 0016-7037, E-ISSN 1872-9533, Vol. 241, s. 120-133Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Silicon isotope values (δ30SiDSi) of dissolved silicon (DSi) have been analyzed in the Lena River and its tributaries, one of the largest Arctic watersheds in the world. The geographical and temporal variations of δ30SiDSi range from +0.39 to +1.86 ‰ with DSi concentrations from 34 to 121 μM. No obvious patterns of DSi concentrations and δ30SiDSi values were observed along over 200 km of the two major tributaries, the Viliui and Aldan Rivers. In summer, the variations of DSi concentrations and δ30SiDSi values in the water are either caused by biological uptake by higher plants and phytoplankton or by mixing of water masses carrying different DSi concentrations and δ30SiDSi values. DSi in tributaries from the Verkhoyansk Mountain Range seems to be associated with secondary clay formation that increased the δ30SiDSi values, while terrestrial biological production is likely more prevalent in controlling δ30SiDSi values in Central Siberian Plateau and Lena Amganski Inter-River Area. In winter, when soils were frozen, the δ30SiDSi values in the river appeared to be controlled by weathering and clay formation in deep intrapermafrost groundwater. During the spring flood, dissolved silicate materials and phytoliths were flushed from the upper thawed soils into rivers, which reset δ30SiDSi values to the values observed prior to the biological bloom in summer. The results indicate that the Si isotope values reflect the changing processes controlling Si outputs to the Lena River and to the Arctic Ocean between seasons. The annual average δ30SiDSi value of the Lena Si flux is calculated to be +0.86±0.3 ‰ using measured δ30SiDSi values from each season. Combined with the estimate of +1.6±0.25 ‰ for the Yenisey River, an updated δ30SiDSi value of the major river Si inputs to the Arctic Ocean is estimated to be +1.3±0.3 ‰. This value is expected to shift towards higher values in the future because of the impacts from a variety of biological and geochemical processes and sources under global warming.

     

  • Heinig, Stefanie
    et al.
    KTH, Skolan för elektroteknik och datavetenskap (EECS), Elkraftteknik.
    Jacobs, Keijo
    KTH, Skolan för elektroteknik och datavetenskap (EECS), Elkraftteknik.
    Ilves, Kalle
    ABB Corp Res, Forskargrand 7, SE-72178 Vasteras, Sweden..
    Norrga, Staffan
    KTH, Skolan för elektroteknik och datavetenskap (EECS), Elkraftteknik.
    Nee, Hans-Peter
    KTH, Skolan för elektroteknik och datavetenskap (EECS), Elkraftteknik.
    Reduction of Switching Frequency for the Semi-Full-Bridge Submodule Using Alternative Bypass States2018Inngår i: 2018 20TH EUROPEAN CONFERENCE ON POWER ELECTRONICS AND APPLICATIONS (EPE'18 ECCE EUROPE), IEEE , 2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    As regards modular multilevel converter submodules, a different number of switches may be involved in the transitions between voltage levels depending on the submodule type and choice of switching states. In this paper, an investigation of the average switching frequency associated with different choices of bypass states is performed for the semi-full-bridge submodule. Theoretical considerations and simulation results show that the average switching frequency per device can be halved by using the proposed alternative bypass state. Moreover, the switching losses can be reduced by up to 60%. Finally, a comparative study with the full-bridge submodule has been conducted.

  • Bergen, K.
    et al.
    Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.
    Frodin, M.
    Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.
    von Gertten, C.
    Karolinska Inst, Dept Clin Neurosci, S-17176 Stockholm, Sweden.
    Sandberg-Nordqvist, A. -C
    Department of Clinical Neuroscience, Karolinska Institutet.
    Sköld, Mattias K.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Neurokirurgi. Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.
    Neurite Growth and Polarization on Vitronectin Substrate after in Vitro Trauma is not Enhanced after IGF Treatment2018Inngår i: Brain Sciences, ISSN 2076-3425, E-ISSN 2076-3425, Vol. 8, nr 8, artikkel-id 151Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Following traumatic brain injuries (TBI), insulin-like growth factor (IGF) is cortically widely upregulated. This upregulation has a potential role in the recovery of neuronal tissue, plasticity, and neurotrophic activity, though the molecular mechanisms involved in IGF regulation and the exact role of IGF after TBI remain unclear. Vitronectin (VN), an extracellular matrix (ECM) molecule, has recently been shown to be of importance for IGF-mediated cellular growth and migration. Since VN is downregulated after TBI, we hypothesized that insufficient VN levels after TBI impairs the potential beneficial activity of IGF. To test if vitronectin and IGF-1/IGFBP-2 could contribute to neurite growth, we cultured hippocampal neurons on +/- vitronectin-coated coverslips and them treated with +/- IGF-1/IGF binding protein 2 (IGFBP-2). Under same conditions, cell cultures were also subjected to in vitro trauma to investigate differences in the posttraumatic regenerative capacity with +/- vitronectin-coated coverslips and with +/- IGF-1/IGFBP-2 treatment. In both the control and trauma situations, hippocampal neurons showed a stronger growth pattern on vitronectin than on the control substrate. Surprisingly, the addition of IGF-1/IGFBP-2 showed a decrease in neurite growth. Since neurite growth was measured as the number of neurites per area, we hypothesized that IGF-1/IGFBP-2 contributes to the polarization of neurons and thus induced a less dense neurite network after IGF-1/IGFBP-2 treatment. This hypothesis could not be confirmed and we therefore conclude that vitronectin has a positive effect on neurite growth in vitro both under normal conditions and after trauma, but that addition of IGF-1/IGFBP-2 does not have a positive additive effect.

  • Peters, Greg
    et al.
    Chalmers University of Technology, Sweden.
    Sandin, Gustav
    RISE - Research Institutes of Sweden, Bioekonomi, Bioraffinaderi och energi.
    Spak, Björn
    RISE - Research Institutes of Sweden, Bioekonomi, Bioraffinaderi och energi.
    Roos, Sandra
    RISE - Research Institutes of Sweden, Swerea, Swerea IVF AB.
    LCA on fast and slow garment prototypes2018Rapport (Annet vitenskapelig)
    Abstract [en]

    This report summarises the environmental assessment work done in the Mistra Future Fashion program focussed on the potential to improve the environmental performance of garments and adapt them to a circular economy. The approaches examined in this report include reducing the environmental impacts from fast-fashion trends by making garments from paper-based materials, or by extending garment life cycles.

    This assessment considers two paper-based garments. One is made primarily from paper pulp but enhanced with a polylactic acid polymer. This garment is worn between two to five times before being recycled as newspaper. The other fast garment is made of paper pulp, polylactic acid and nanocellulose. It has a similar life cycle but is composted after use life. These garments are compared with a standard t-shirt. The report also considers a slow-paced scenario in which a polyester garment passes between several owners and is regularly changed to maintain its appeal. It is updated with a transfer sublimation overprint three times, making the garment darker each time. Later it is joined with an outer shell of new material using laser technology to make a cropped, box-cut jacket.

    The assessment was performed using environmental life cycle assessment. More particularly, the assessment was based on attributional process analysis with cutoff allocation procedures and comparison with a traditional reference garment life cycle. Key environmental effect categories considered here include climate change (greenhouse gas emissions), freshwater eutrophication, freshwater ecotoxicity and human toxicity (cancer and non-cancer).

    The results indicate that the environmental outcomes of the paper-based garments can be competitive with the reference garment, particularly when the user is assumed to throw away a fully functional reference garment after five uses. This assumption may be true for some users, but the number of uses is considerably lower than the typical or the potential lifespan of the reference garment. The main factor assisting the paper-based garments is the reduction in the impacts per mass associated with material manufacturing (fibres, spinning, knitting), and also their lighter masses. Avoided impacts in the use phase play a secondary role on account of their location in Sweden with its low-carbon energy mix. The long-life garments are also competitive compared with their reference garments. This is primarily a consequence of how extending garment life avoids the production of new garments. The environmental impacts associated with transfer sublimation dye reprinting and laser processing do not significantly impact the overall environmental performance of the extended longlife garments, though confidentiality of data prevents a full assessment of these.

    The garments in this report are pilot products and explorative scenarios rather than attempts to model existing business or behavioural patterns. The reader should therefore take care to keep the results in context when interpreting them. Nevertheless, the results suggest the value of pursuing the potential associated with these garment life cycles. We should also bear in mind that while the reference garments in this assessment are based on typical usage patterns, other more sustainable patterns are feasible.

  • Fors Connolly, Filip
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Sociologiska institutionen.
    Johansson Sevä, Ingemar
    Umeå universitet, Samhällsvetenskapliga fakulteten, Sociologiska institutionen.
    Social status and life satisfaction in context: a comparison between Sweden and the USA2018Inngår i: International Journal of Wellbeing, ISSN 1179-8602, E-ISSN 1179-8602, Vol. 8, nr 2, s. 110-134Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Previous research has shown that social status is an important predictor of life satisfaction (LS). However, researchers have largely focused on the United States, which raises questions about the extent to which the cultural context moderates the relationship between social status and LS. In this paper, we argue that the dominant cultural orientations in society most likely influence the strength of the relationship between social status and LS. Cultural orientations emphasizing competition, achievement and assertiveness should increase the positive influence of social status on LS, while cultural emphases on cooperation, equality and humility instead weakens the effect of status. We therefore analyze the social status-LS relationship in two distinctly different cultural contexts, i.e., Sweden and the United States. Based on theories about national differences in cultural value orientations, we argue that social status should be of more importance in the US compared to in Sweden, since the dominant values and ideals emphasize hierarchy, mastery and masculinity, while the Swedish culture represents an opposite pole by emphasizing egalitarianism, harmony, and femininity. We formulate a number of hypotheses and use survey data to examine the extent to which both social status attainment and social status seeking are related to LS in both countries. The results show that socioeconomic status (income) and sociometric status (perceived respect and admiration in everyday life) have a stronger influence on LS in the US compared to in Sweden. Further, the findings show that social status seeking (low honesty-humility) has a positive relationship to LS in the US, but is negatively related in Sweden. The results also show that gender differences in the relationship between social status and LS are more pronounced in the US compared to in Sweden. We conclude that both the attainment and pursuit of social status are more important for LS in the American cultural context compared to in the Swedish, especially among men. These findings are in line with our expectations, based on the opposing cultural orientations in Sweden and the US. The study contributes to the literature on the relationship between social status and LS, but also to the more general literature on the moderating influence of culture on the predictors of LS.