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  • Davishpour, Mehrdad
    Stockholms universitet.
    En bild av kvinnornas försämrade situation i Iran1993Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 30, nr 3, 47-62 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A picture of the deteriorating situation for women in Iran

    After the Islamic Revolution in Iran 1978-79, the situation has become much worse for women, in terms of rights and resources. The aim of this article is to describe this change with the help of demographic data and to argue that it is the result of the repressive policy of the Islamic regime and, ultimately, of islamic ideology. In particular, Iranian women suffer from the return to more traditional laws of marriage and from reduced opportunities to get an education, or a job.

  • Berggren, Christian
    et al.
    KTH.
    Laestadius, Staffan
    KTH.
    Pyramider eller horisontella nät? Kreativitet, kompetensutveckling och prestationskrav i olika slags industriella produktionssystem1993Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 30, nr 3, 30-46 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Pyramids or horisontal nets? Creativity, competence and performance in different types of production systems

    In recent years, we have witnessed a marked increase in the international interest in industrial networks and in relations between manufacturers and suppliers. An important reason for this is the expansion of the Japanese automobile industry. This industry is organized into a huge structure of subcontractors, vertically related and dominated by demanding large-scale enterprises. An entirely different pattern can be found, especially in northern Italy, but also in southern Germany and in Denmark, where enterprises form horisontal networks. In these geographically dense areas, small and medium-sized firms both cooperate and compete intensely. The respective roles of suppliers and manufacturer are diffuse, social mobility is high and the development of new products rapid. Swedish research on working life has tended to focus on processes within firms and public administration. Industrial structure has largely been accepted as given, while its effects on competence and performance has been neglected areas of research. In this article a research project is presented, which aims at investigating the effects of industrial structure on the developmental potential of, and work conditions in, firms. Our intention is to study vertical pyramids, especially in the automobile industry, and horisontal networks in, for instance, the sailing-boat industry. A central problem concern the effects of different types of industry on creativity and scope for action in small and medium-sized companies.

  • Björnberg, Ulla
    Göteborgs universitet.
    Familjepolitik i EG-länderna ur ett kvinnoperspektiv1993Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 30, nr 3, 3-29 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Family policies in the EC-countries from a female perspective

    The purpose of this article is to problematize the family policies in the EC-countries from a female perspective. The article emphasizes the family policies as motherhood policies in the twelve EC-countries. In my examples, I have focussed particularly on the phase of childbirth and the care for small children in the family cycle. My interest is to analyze the implication of the family policies for women’s life chances, integrity and autonomy. In the article, an overview of the rules that afflict mothers’ possibilities to be employed and attain autonomy is presented. A majority of the EC-countries have introduced separate taxation between spouses with the motivation to stimulate women’s employment. Many rights concerning possibilites to conciliate employment and family have been introduced in the EC-countries during the late 1980’s and the early 1990’s. The rule systems are difficult to grasp and appear to work in the opposite direction in their consequences, which renders comparisons between the countries more difficult. Many questions can be asked concerning the joint effects of the taxation system, allowance regulations and rights concerning possibilities to conciliate employment and family for women in different social strata respectively, and detailed studies of how the rule systems work for these women in different social strata are required. A general conclusion is that mothers are nowadays granted the right to employment and the right to keep it when they have children. Men have almost in all EC-countries received extended possibilities to take leave in connection to their becoming fathers. Simultaneously, married/cohabitant women’s economic dependence on men is asserted/reinforced by tax-systems, allowance regulations and shortages of child care. I also stress the need to study rules within the different social security systems in detail. This becomes particularly relevant when one studies women, since social security systems are based on paid work. Since women have salaried work on odder premises, they run the risk of not qualifying for support or not being insured at all. In the article, I argue the family policies shall be directed more particularly towards theproblems of the women and the children in the families. The gender-neutral perspective that in most cases is pre-dominant is in fact a male perspective. It is chiefly mothers who put the most effort and time into families. It is mothers that de facto have the main responsibility for the children in the family. Therefore it is also essential that the family policies more consciously proceed to strengthen the women’s (and the children’s) position and direct measures towards the problems that mothers have in families.

  • Udehn, Lars
    Uppsala universitet.
    Sociologisk Forskning 1993:31993Collection/Antologi (Fagfellevurdert)
  • Recensioner1993Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 30, nr 4, 84-110 s.Artikkel, omtale (Annet vitenskapelig)
  • Jönhill, Jan Inge
    Lunds universitet.
    Från ideal via paradox till problem. Individualiteten och kärleken i Niklas Luhmanns systemteori1993Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 30, nr 4, 68-83 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    From ideal via paradox to problem. Individuality and love in Niklas Luhmann's systems theory

    This paper deals, on the one hand, with the question of man as an individual and his relationship to society and, on the other hand, with the sociology of love and intimacy and hence with the sociology of modern individualization. The aim is to introduce for Scandinavian sociology the German sociologist Niklas Luhmann, especially with regard to these themes and, at the same time, his radical and new conception of social systems. It is often suggested that sociological systems theory can only deal with macro level problems, and not with the micro level; of understanding problems on the individual level. In Luhmann’s approach this is no longer the case. The individual is conceived of as strictly belonging outside of society, as part of the environment. Only as person is it possible to identify man inside social systems. But in using the distinction between system and environment, both environment and system is focused upon. Love is analyzed primarily as a semantic code and not as a feeling (as is often the case). The thesis is that only as a code can love be expressed in its emotionality. In his book Love as Passion (an excellent example of historical sociology) the code of love is observed from Middle Ages as an ideal form, via its form of paradox, till today when love as a problem of the family system is penetrated by specialists of all kinds. Luhmann’s intention is not to find a solution for the family, but to provide an understanding for solutions which are contingent.

  • Holmberg, Carin
    Göteborgs universitet.
    Välfärdsstaten och den obligatoriska heterosexualiteten1993Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 30, nr 4, 56-67 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The welfare state and compulsory heterosexuality

    The welfare state has been scrutinized from different angles. Here the author tries to show how the welfare state enforces heterosexuality as a norm for the good life. Welfare reforms regarding family law, adoption, insemination, and some social insurances, are discussed. Sweden and Denmark are used for comparison, since Denmark is the only country in the world which gives homosexuals right to civil marriage. This civil marriage has a special name: partnership (partnerskap). One question that can be asked is if partnership challanges the norm of heterosexuality since lesbian and gay lives are accepted by the state. But there is a similarity as well as a difference between the laws regarding equality between the sexes (jämställdhet) and the laws regarding homosexuals. In the first case it is man who is the norm for the good life and women are given the same rights as men. In the second case it is the heterosexuals who are the norm for the good life but homosexuals are only given some of their rights.

  • Lidskog, Rolf
    Högskolan i Örebro.
    Skapandet av tillit i en riskkontext. Om social riskacceptans vid lokalisering av anläggningar för radioaktivt och miljöfarligt avfall1993Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 30, nr 4, 33-55 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [sv]

    Skapandet av tillit i en riskkontext. Om social riskacceptans vid lokalisering av anläggningar för radioaktivt och miljöfarligt avfall

    Taking Beck’s and Giddens’ recent formulation of the society’s new conditions for gaining trust as theoretical point of departure, this article focusses trust and risk with regard to hazardous and radioactive waste disposal in Sweden. Seeing trust as intimately connected with cognitive understanding of risks, the information strategies of the companies with responsibility for hazardous and radioactive waste management are analysed. Central in gaining trust is the creation of access points - points of connection between lay individuals or collectivities and the representatives of expert systems - at which trust can be built up or maintained. This article emphasizes that this kind of locational conflict is to be seen as a struggle concerning the cognitive understanding of risk-generating activities, and the question is to what extent the cognitive understanding of nuclear companies will be accepted among the affected local population and to what extent the local population will develop and maintain an alternative cognitive understanding.

  • Gustafsson, Rolf Å
    Karolinska institutet.
    Ekonomi, politik, civilitet: Ett handlingsteoretiskt bidrag till diskussionen om marknad, stat och civilsamhälle1993Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 30, nr 4, 3-32 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Economics, politics and civility - towards an action-theoretical discourse on market, state and civil society

    In the recent Swedish debate on the welfare state a controversy has arisen over the potentials and pitfalls of the market, the state and civil society. It is argued that there is a tendency to hypostatize this triad. The article sets out to show that the difficulties this raises can be counteracted by inserting an action-theoretical frame of reference into the debate. Three main alternative frames of reference are considered: rational choice, Weberian sociology and Habermas’ communicative action. These are analyzed from the perspective oftheir contextualizing and autonomizing potentials, i.e . in terms of how they relate actorsto their social context, and how they handle the problem of voluntarism. It is shown that rational choice theories - basically relevant to the economics of scarce resources - face insurmountable difficulties when confronted by the utilitarian dilemma formulated by Parsons in the late 30s. Weber can be associated with an analytical approach to politics - focusing on binding decisions taken by legitimate source of authority - but his approach still fails to resolve the problem of human agency and autonomy. At this point, a crucial distinction is made between primary and secondary feedback in models of action. It is argued that Habermas/Schluchter, in their interpretation of Weber, implicitly make such a distinction. This opens up a socio-political dimension in models of action. Nevertheless, in the Weberian case, the agent is still regarded as a rule-follower, and the intersubjective foundations of value systems remain a puzzle. The significance of the theory of communicative action lies in its attempt to handle the problem of civility, as formulated by Ferguson and Tönnies; the human being is regarded as a rule-maker. It is misleading to regard the state, the market and civil society as alternative entities or arenas for social welfare activities. It is more fruitful to focus on the analytic concept of civility as a necessary precondition for political and economic measures designed to enhance autonomy.

  • Campeau, Audrey
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Luft-, vatten och landskapslära. Uppsala University, Department of Air Water and Landscape.
    Dataset for manuscript : Stable carbon isotopes reveal soil-stream DIC linkages in contrasting headwater catchments2018Dataset
  • Udehn, Lars
    Uppsala universitet.
    Sociologisk Forskning 1993:41993Collection/Antologi (Fagfellevurdert)
  • Nyberg, André
    et al.
    Wadell, Karin
    Lindgren, Helena
    Tistad, Malin
    Högskolan Dalarna, Akademin Utbildning, hälsa och samhälle, Medicinsk vetenskap. Umeå universitet, Institutionen för samhällsmedicin och rehabilitering, Fysioterapin.
    Internet-based support for self-management strategies for people with COPD-protocol for a controlled pragmatic pilot trial of effectiveness and a process evaluation in primary healthcare2017Inngår i: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 7, nr 7, e016851Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    INTRODUCTION: The use of adequate self-management strategies for people with chronic obstructive pulmonary disease (COPD) reduces healthcare use, improves health-related quality of life (HRQoL) and recovery after acute exacerbations. However, not many people with COPD receive support that promotes the use of such strategies and therefore new methods to facilitate and promote the use of self-management strategies are highly warranted. This pilot trial aims to evaluate the feasibility of the study design and study procedures considering effectiveness of the novel intervention, the COPD-web. METHODS AND ANALYSIS: The overall design is a pragmatic controlled pilot trial with preassessments and postassessments and a parallel process evaluation. Patients with the diagnosis of COPD will be eligible for the study. The intervention group will be recruited when visiting one of the six participating primary care units in Sweden. The control group will be identified from the unit's computerised registers. The intervention, the COPD-web, is an interactive web page with two sections; one directed at people with COPD and one at healthcare professionals. The sections aim to support patients' self-management skills-and to facilitate the provision of support for self-management strategies, respectively. Effectiveness with regard to patients' symptoms, HRQoL, knowledge of and readiness for COPD-related self-management, health literacy, self-efficacy for physical activity and time spent in physical activity and time being sedentary, and further, healthcare professionals' knowledge of and readiness to support COPD-related self-management strategies will be assessed using questionnaires at 3 and 12 months. The process evaluation will include observations and interviews.

    ETHICS AND DISSEMINATION: Ethical approval has been obtained. Findings will be presented at conferences, submitted for publication in peer-reviewed publications and presented to the involved healthcare professionals, patients and to patient organisations.

    TRIAL REGISTRATION NUMBER: ClinicalTrials.gov: NCT02696187.

  • Olausson, Pär M.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för samhällsvetenskap.
    Styrel - mot en elförsörjning2017Inngår i: Hållbarhetens många ansikten: samtal, forskning och fantasier / [ed] Edith Andresen, Gustav Lidén, Sara Nyhlén, Östersund: Mid Sweden University , 2017, 80-88 s.Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [sv]

    STYREL är en planeringsprocess som syftar till att minimera konsekvenserna för samhället vid en situation av elbrist. Processen har utvecklats av Statens energimyndighet (EM) i samarbete med Myndigheten för samhällsskydd och beredskap (MSB) och Svenska kraftnät (SvK). Länsstyrelsen spelar en viktig roll i Styrel genom sin uppgift som samordnare på regional nivå. Följande kapitel syftar till att ge en kort beskrivning av Styrel som en del av det svenska krishanteringssystemet samt att ge en bild av hur de samordningsansvariga på länsstyrelsen uppfattar sin roll i Styrel.

    Kapitlet utgår från en mer omfattande studie under rubriken Från myndighet till medborgare och tillbaka. Syftet med projektet är att

    • Öka kunskapen om hur samverkan inom ramen för Styrel sker
    • Öka om hur prioriteringar skapas och hur dessa omsätts i operativ planering i syfte att skapa goda förutsättningar för att förfina planeringsprocessen
    • Bidra med kunskap om hur en planerings- och beslutsprocess med flera aktörer med systematik bildar ett väl avvägt operativt underlag i händelse av krisscenario.

    Studien omfattar dokumentstudier samt intervjuer med STYRELsansvariga i kommun, region/landsting och länsstyrelse samt ansvariga på utvalda myndigheter. 

  • Wass, Sofie
    Högskolan i Jönköping, Internationella Handelshögskolan, IHH, Informatik.
    The importance of eHealth innovations: Lessons about patient accessible information2017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Access to digital information and communication has an increasing importance in both the work of healthcare professionals and in patients’ everyday life and has transformed what we do and how we carry out activities. It changes the way in which healthcare is delivered, how information is exchanged within and between organizations and how patients and other actors access and manage information. Currently, innovation is imperative in the healthcare sector and today there is a focus on how different eHealth services can improve healthcare. With increased access to various eHealth services, there is a need to know more about the impact of eHealth innovations on healthcare.

    The aim of this thesis is to acquire more knowledge about eHealth innovations in healthcare. The focus is on prerequisites to realize innovative eHealth services and eHealth services that provide patients with access to health information. The theoretical background addresses innovation, services and business models. This thesis is a compilatory work and includes five qualitative research papers. The first study is an interview study, the second is a literature review and the remaining three are case studies. The data collection consisted of interviews, surveys, workshops and secondary data collected from documents. The interview study and the case studies were performed in the Swedish eHealth setting.

    The research contributes to our understanding of eHealth innovations with insights on prerequisites to realize eHealth innovations and knowledge on patient accessible information. The first study provides a classification of prerequisites that need to be considered to realize innovative eHealth services. When dealing with eHealth services, organizational and sematic interoperability are still a challenge, and they transcend organizational boundaries. This thesis provides knowledge on the recent trend of opening up electronic health records to patients. The knowledge derived from the studies on patient accessible electronic health records show that there is a discrepancy between the perceptions of patients and healthcare professionals. The thesis concludes that patients feel more involved and that the patient-professional relationship improves with patient access to electronic health records, whereas healthcare professionals have concerns about how patients will manage access to health information. This thesis also provides empirical insights on how business models can be represented in a public eHealth setting. By viewing public eHealth services as social innovations, the thesis contributes to the research on business models in a public healthcare setting by incorporating societal value into the representation of the business model.

    The research in this thesis contributes to research in health informatics by discussing issues related to eHealth innovations and patient accessible information. Its practical importance lies in identifying issues that are important when discussing eHealth initiatives and the implications of giving patients online access to their electronic health record.

  • Lundqvist, Stefan
    Försvarshögskolan, Militärvetenskapliga institutionen (MVI), Taktikavdelningen (TA), Marinsektionen (Marin).
    Continuity and Change in post-Cold War Maritime Security: A Study of the Strategies Pursued by the US, Sweden and Finland 1991-20162017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    What explains continuity and change in post-Cold War maritime security strategies? What lessons can we learn from the employment of such comprehensive grand strategies in maritime regions where traditional and non-traditional threats converge? While many scholars have addressed particular maritime security issues, this author joins the few who engage themselves in the study of the conceptual development of maritime security.

    Through the lens of structural realism, this thesis examines the logic of the maritime security strategies employed in two distinguished regions by the US and EU member states Finland and Sweden. It concludes that while their maritime security concept remains broad, the recent increase in security pressure has renewed the priority assigned to the military sector of security. Navies are thus re-using the measures implemented by a broad set of civil agencies and the shipping industry to improve maritime security, to gain the level of maritime domain awareness required for establishing regional sea control and project power from the sea.

  • Puschnig, J.
    et al.
    Stockholm Univ, AlbaNova Univ Ctr, Dept Astron, Oskar Klein Ctr, SE-10691 Stockholm, Sweden..
    Hayes, M.
    Stockholm Univ, AlbaNova Univ Ctr, Dept Astron, Oskar Klein Ctr, SE-10691 Stockholm, Sweden..
    Ostlin, G.
    Stockholm Univ, AlbaNova Univ Ctr, Dept Astron, Oskar Klein Ctr, SE-10691 Stockholm, Sweden..
    Rivera-Thorsen, T. E.
    Stockholm Univ, AlbaNova Univ Ctr, Dept Astron, Oskar Klein Ctr, SE-10691 Stockholm, Sweden..
    Melinder, J.
    Stockholm Univ, AlbaNova Univ Ctr, Dept Astron, Oskar Klein Ctr, SE-10691 Stockholm, Sweden..
    Cannon, J. M.
    Macalester Coll, Dept Phys & Astron, 1600 Grand Ave, St Paul, MN 55105 USA..
    Menacho, V.
    Stockholm Univ, AlbaNova Univ Ctr, Dept Astron, Oskar Klein Ctr, SE-10691 Stockholm, Sweden..
    Zackrisson, E.
    Uppsala Univ, Dept Phys & Astron, Lagerhyddsvagen 1, SE-75120 Uppsala, Sweden..
    Bergvall, Nils
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Observationell astrofysik.
    Leitet, Elisabet
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Observationell astrofysik.
    The Lyman continuum escape and ISM properties in Tololo 1247-232-new insights from HST and VLA2017Inngår i: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 469, nr 3, 3252-3269 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Low- and intermediate-mass galaxies are widely discussed as cause of reionization at redshift z similar to 10-6. However, observational proof of galaxies that are leaking ionizing radiation (Lyman continuum; LyC) is a currently ongoing challenge and the list of LyC emitting candidates is still short. Tololo 1247-232 is among those very few galaxies with recently reported leakage. We performed intermediate resolution ultraviolet spectroscopy with the Cosmic Origins Spectrograph onboard the Hubble Space Telescope and confirm ionizing radiation emerging from Tololo 1247-232. Adopting an improved data reduction procedure, we find that LyC escapes from the central stellar clusters, with an escape fraction of 1.5 +/- 0.5 per cent only, i.e. the lowest value reported for the galaxy so far. We further make use of far-ultraviolet absorption lines of Si II and Si IV as a probe of the neutral and ionized interstellar medium ( ISM). We find that most of the ISM gas is ionized, likely facilitating LyC escape from density bounded regions. Neutral gas covering as a function of line-of-sight velocity is derived using the apparent optical depth method. The ISM is found to be sufficiently clumpy, supporting the direct escape of LyC photons. We further report on broad-band UV and optical continuum imaging as well as narrow-band imaging of Lya, Ha and H beta. Using stellar population synthesis, an Lya escape fraction of 8 per cent was derived. We also performed Very Large Array 21cm imaging. The hydrogen hyperfine transition was not detected, but a deep upper limit atomic gas mass of less than or similar to 10(9) M-circle dot could be derived. The upper limit gas fraction defined as M-HI/M-* is only 20 per cent. Evidence is found that the HI gas halo is relatively small compared to the Lyman Alpha Reference Sample (Hayes et al. 2013, 2014; Ostlin et al. 2014).

  • Netterberg, Ida
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Nielsen, Elisabet I.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Friberg, Lena E
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Karlsson, Mats O.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring2017Inngår i: Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, E-ISSN 1432-0843, Vol. 80, nr 2, 343-353 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose To investigate whether a more frequent monitoring of the absolute neutrophil counts (ANC) during myelo-suppressive chemotherapy, together with model-based predictions, can improve therapy management, compared to the limited clinical monitoring typically applied today. Methods Daily ANC in chemotherapy-treated cancer patients were simulated from a previously published population model describing docetaxel-induced myelosuppression. The simulated values were used to generate predictions of the individual ANC time-courses, given the myelosuppression model. The accuracy of the predicted ANC was evaluated under a range of conditions with reduced amount of ANC measurements. Results The predictions were most accurate when more data were available for generating the predictions and when making short forecasts. The inaccuracy of ANC predictions was highest around nadir, although a high sensitivity (>= 90%) was demonstrated to forecast Grade 4 neutropenia before it occurred. The time for a patient to recover to baseline could be well forecasted 6 days (+/- 1 day) before the typical value occurred on day 17. Conclusions Daily monitoring of the ANC, together with model-based predictions, could improve anticancer drug treatment by identifying patients at risk for severe neutropenia and predicting when the next cycle could be initiated.

  • Roos, Anna
    et al.
    Utförare miljöövervakning, Naturhistoriska riksmuseet, NRM.
    Loso, Katarina
    Utförare miljöövervakning, Naturhistoriska riksmuseet, NRM.
    Fång, Johan
    Utförare miljöövervakning, Naturhistoriska riksmuseet, NRM.
    Mätningar av läkemedelsrester i blod och urin från utter2017Rapport (Annet vitenskapelig)
    Abstract [sv]

    Denna rapport är den första delen av två i en pilotstudie om läkemedelsrester i utter. I den första delen ville vi undersöka om det gick att analysera rester av läkemedel i urin och blod från utter, samt att utvärdera vilken matris som är mest lämplig för ändamålet.

    Vi har analyserat 30 olika läkemedelsrester i blod och urin från 20 poolade prover som innehöll blod respektive urin från 33 uttrar. Samtliga läkemedel fanns i blod och/eller urinprover, dock inte i alla prov. Ett flertal ämnen låg under kvantificerbar nivå (<LOQ). Det innebär att man kan se att de finns i provet men pga "brus" inte kan kvantificera det.

    Det antidepressiva medlet Venlafaxin fanns i samtliga tio blodprover (0,24-2,0 ng/g färskvikt) men inte alls i urinproverna. Risperidone som används vid behandling av bl.a. schitzofreni fanns i mätbara halter i 7 av de 10 blodproven (4,3-250 ng/g färskvikt) och 7 av 10 urinprov (0,12-46 ng/g färskvikt).

    Högst antal läkemedelsrester i urinet hade en utter från Västervik (11 st + 4 st <LOQ). Den hade också mätbara halter från 7 olika läkemedelsrester i blodet (+ 4 st <LOQ).

    Det fanns fler mätbara läkemedel i urinproverna jämfört med blodproverna, med ett undantag (Venlafaxin). Dessvärre är urin begränsande, de flesta uttrar som inkommer till museet har tom eller nästan tom urinblåsa. Att blodprov ändå fungerar bra är positivt. Det är oftast möjligt att ta blod från uttrarna som skickas in och därför föreslår vi att man i fortsättningen analyserar blod, och urin bara i de fall där det är möjligt.

  • Mattsson, Gustav
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Gävleborg.
    Magnusson, Peter
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Gävleborg. Karolinska Inst, Dept Med, Cardiol Res Unit, Stockholm, Sweden.
    Electrical storm in the inflamed heart: ventricular tachycardia due to myocarditis2017Inngår i: Clinical Case Reports, E-ISSN 2050-0904, Vol. 5, nr 8, 1327-1332 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Key Clinical Message Electrical storm during the acute inflammatory phase caused by myocarditis may be resistant to antiarrhythmic therapy. Cardiac imaging including magnetic resonance tomography, positron emission tomography, and endomyocardial biopsy are crucial to guide potential therapeutic options. Optimal management involves a multidisciplinary approach, including expertise beyond cardiology.

  • Söderquist, Pär
    et al.
    Högskolan Kristianstad, Forskningsmiljön Man & Biosphere Health (MABH). Högskolan Kristianstad, Sektionen för lärande och miljö, Avdelningen för Naturvetenskap.
    Elmberg, Johan
    Högskolan Kristianstad, Sektionen för lärande och miljö, Avdelningen för Naturvetenskap. Högskolan Kristianstad, Forskningsmiljön Man & Biosphere Health (MABH).
    Gunnarsson, Gunnar
    Högskolan Kristianstad, Sektionen för lärande och miljö, Avdelningen för Naturvetenskap. Högskolan Kristianstad, Forskningsmiljön Man & Biosphere Health (MABH).
    Thulin, C-G
    University of Agricultural Sciences.
    Champagnon, J
    Frankrike.
    Guillemain, M
    Frankrike.
    Kreisinger, J
    Tjeckien.
    Prins, H T
    Holland.
    Crooijmans, R. P. M. A.
    Holland.
    R. H. S., Kraus
    Admixture between released and wild game birds: a changing genetic landscape in European mallards (Anas platyrhynchos)2017Inngår i: European Biophysics Journal, ISSN 0175-7571, E-ISSN 1432-1017Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Disruption of naturally evolved spatial patterns of genetic variation and local adaptations is a growing concern in wildlife management and conservation. During the last decade, releases of native taxa with potentially non-native genotypes have received increased attention. This has mostly concerned conservation programs, but releases are also widely carried out to boost harvest opportunities. The mallard, Anas platyrhynchos, is one of few terrestrial migratory vertebrates subjected to large-scale releases for hunting purposes. It is the most numerous and widespread duck in the world, yet each year more than three million farmed mallard ducklings are released into the wild in the European Union alone to increase the harvestable population. This study aimed to determine the genetic effects of such large-scale releases of a native species, specifically if wild and released farmed mallards differ genetically among subpopulations in Europe, if there are signs of admixture between the two groups, if the genetic structure of the wild mallard population has changed since large-scale releases began in the 1970s, and if the current data matches global patterns across the Northern hemisphere. We used Bayesian clustering (Structure software) and Discriminant Analysis of Principal Components (DAPC) to analyze the genetic structure of historical and present-day wild (n = 171 and n = 209, respectively) as well as farmed (n = 211) mallards from six European countries as inferred by 360 single-nucleotide polymorphisms (SNPs). Both methods showed a clear genetic differentiation between wild and farmed mallards. Admixed individuals were found in the present-day wild population, implicating introgression of farmed genotypes into wild mallards despite low survival among released farmed mallards. Such cryptic introgression would alter the genetic composition of wild populations and may have unknown long-term consequences for conservation.

  • Hällgren, Sebastian
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Some aspects on designing for metal Powder Bed Fusion2017Licentiatavhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Additive Manufacturing (AM) using the Powder Bed Fusion (PBF) is a relatively new manufacturing method that is capable of creating shapes that was previously practically impossible to manufacture. Many think it will revolutionize how manufacturing will be done in the future. This thesis is about some aspects of when and how to Design for Additive Manufacturing (DfAM) when using the PBF method in metal materials. Designing complex shapes is neither easy nor always needed, so when to design for AM is a question with different answers depending on industry or product. The cost versus performance is an important metric in making that selection. How to design for AM can be divided into how to improve performance and how to improve additive manufacturability where how to improve performance once depends on product, company and customer needs. Using advanced part shaping techniques like using Lattices or Topology Optimization (TO) to lower part mass may increase customer value in addition to lowering part cost due to faster part builds and less powder and energy use. Improving PBF manufacturability is then warranted for parts that reach series production, where determining an optimal build direction is key as it affects many properties of PBF parts. Complex shapes which are designed for optimal performance are usually more sensitive to defects which might reduce the expected performance of the part. Non Destructive Evaluation (NDE) might be needed to certify a part for dimensional accuracy and internal defects prior use. The licentiate thesis covers some aspects of both when to DfAM and how to DfAM of products destined for series production. It uses design by Lattices and Topology Optimization to reduce mass and looks at the effect on part cost and mass. It also shows effects on geometry translation accuracies from design to AM caused by differences in geometric definitions. Finally it shows the effect on how different NDE methods are capable of detecting defects in additively manufactured parts.

  • Berggren, Olof
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Hagberg, Niklas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Alexsson, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Weber, Gert
    Ernst Moritz Arndt Univ Greifswald, Inst Biochem, Dept Mol Struct Biol, Greifswald, Germany..
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Eloranta, Maija-Leena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Plasmacytoid dendritic cells and RNA-containing immune complexes drive expansion of peripheral B cell subsets with an SLE-like phenotype2017Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, nr 8, e0183946Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background Hyperactive B cells and a continuous interferon (IFN)-alpha production by plasmacytoid dendritic cells (pDCs) play a key role in systemic lupus erythematosus (SLE). We asked whether the interaction between B cells and pDCs stimulated with RNA-containing immune complexes affects peripheral B cell subsets. Methods B cells and pDCs were isolated from blood of healthy individuals and stimulated with immune complexes consisting of SLE-IgG and U1snRNP (RNA-IC). Expression of cell surface molecules as well as IL-6 and IL-10 production were determined by flow cytometry and immunoassays. Gene expression profiles were determined by a NanoString nCounter expression array. Results We found a remarkable increase of double negative CD27-IgD-B cells, from 7% within fresh CD19+B cells to 37% in the RNA-IC-stimulated co-cultures of B cells and pDCs, comparable to the frequency of double negative B cells in SLE patients. Gene expression analysis of the double negative CD27-IgD -and the CD27 + IgD-memory B cells revealed that twenty-one genes were differentially expressed between the two B cell subsets (>= 2-fold, p< 0.001). The, IL21R, IL4R, CCL4, CCL3, CD83 and the IKAROS Family Zinc Finger 2 (IKZ2) showed higher expression in the double negative CD27-IgD-B cells. Conclusion The interactions between B cells and pDCs together with RNA-containing IC led to an expansion of B cells with similar phenotype as seen in SLE, suggesting that the pDC-B cell crosstalk contributes to the autoimmune feed-forward loop in SLE.

  • Somphonsane, R.
    et al.
    King Mongkuts Inst Technol Ladkrabang, Dept Phys, Bangkok 10520, Thailand..
    Ramamoorthy, H.
    SUNY Buffalo, Dept Elect Engn, Buffalo, NY 14260 USA..
    He, G.
    SUNY Buffalo, Dept Elect Engn, Buffalo, NY 14260 USA..
    Nathawat, J.
    SUNY Buffalo, Dept Elect Engn, Buffalo, NY 14260 USA..
    Kwan, C. -P
    Arabchigavkani, N.
    SUNY Buffalo, Dept Phys, Buffalo, NY 14260 USA..
    Lee, Y. -H
    Fransson, Jonas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori.
    Bird, J. P.
    SUNY Buffalo, Dept Elect Engn, Buffalo, NY 14260 USA.;Chiba Univ, Grad Sch Adv Integrat Sci, Inage Ku, 1-33 Yayoi Cho, Chiba 2638522, Japan..
    Evaluating the Sources of Graphene's Resistivity Using Differential Conductance2017Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 10317Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We explore the contributions to the electrical resistance of monolayer and bilayer graphene, revealing transitions between different regimes of charge carrier scattering. In monolayer graphene at low densities, a nonmonotonic variation of the resistance is observed as a function of temperature. Such behaviour is consistent with the influence of scattering from screened Coulomb impurities. At higher densities, the resistance instead varies in a manner consistent with the influence of scattering from acoustic and optical phonons. The crossover from phonon-, to charged-impurity, limited conduction occurs once the concentration of gate-induced carriers is reduced below that of the residual carriers. In bilayer graphene, the resistance exhibits a monotonic decrease with increasing temperature for all densities, with the importance of short-range impurity scattering resulting in a "universal" density-independent ( scaled) conductivity at high densities. At lower densities, the conductivity deviates from this universal curve, pointing to the importance of thermal activation of carriers out of charge puddles. These various assignments, in both systems, are made possible by an approach of "differential-conductance mapping", which allows us to suppress quantum corrections to reveal the underlying mechanisms governing the resistivity.

  • Ranhem, Cecilia
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    larsson, Gabriella Lillsunde
    Orebro Univ, Sch Hlth & Med Sci, Orebro, Sweden.;Orebro Univ Hosp, Dept Lab Med, Orebro, Sweden..
    Hedman, Hakan
    Umea Univ, Dept Radiat Sci, Umea, Sweden..
    Lindquist, David
    Umea Univ, Dept Radiat Sci, Umea, Sweden..
    Karlsson, Mats G.
    Orebro Univ, Fac Med & Hlth, Dept Lab Med, Orebro, Sweden..
    Hellstrom, Ann-Cathrin
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    Ostensson, Ellinor
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Sorbe, Bengt
    Orebro Univ Hosp, Dept Oncol, Orebro, Sweden..
    Hellman, Kristina
    Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden..
    Andersson, Sonia
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma2017Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, nr 8, e0183816Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and LRIG3. The present study aimed to evaluate the expression of LRIG proteins and analyse their possible associations with clinical characteristics and survival in a cohort of PVC patients. Methods We used immunohistochemistry to investigate LRIG1, LRIG2, and LRIG3 expression in tumour samples from a consecutive cohort of 70 PVC patients. The association between LRIG protein expression and clinical characteristics and cancer-specific survival was investigated using univariate and multivariate analyses. Results The majority of PVC patients (72%) had > 50% LRIG1-and LRIG2-positive cells, and no or low LRIG3-positive cells. HPV status was significantly correlated with LRIG1 expression (p = 0.0047). Having high LRIG1 expression was significantly correlated with superior cancer-specific survival in univariate and multivariate analyses. LRIG2 and LRIG3 expression did not significantly correlate with clinical characteristics or survival. Conclusion LRIG1 expression might be of interest as a prognostic marker in PVC patients, whereas the role of LRIG2 and LRIG3 expression remains to be clarified.

  • Recensioner1994Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 31, nr 1, 58-93 s.Artikkel, omtale (Annet vitenskapelig)
  • Karlsson, Jan C. H
    Försvarets Forskningsanstalt.
    Finns svenskheten? En granskning av teorier om svenskt folklynne, svensk folkkaraktär och svensk mentalitet1994Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 31, nr 1, 41-57 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Does Swedishness exist? A scrutiny of theories about the Swedish national character and mentality

    Three prominent analyses of Swedishness are discussed: Do these analyses make it possible to say that Swedishness exists and, in that case, what characteristics it has? Two problems appear when reading these works. The first I call ’the search light problem’, dealing with what to look for when searching for Swedishness, i.e. a theory that defines the area of research. The other problem concerns levels of analysis; it has to do with how national characteristics are related to, on the one hand, transnational and, on the other hand, crossnational phenomena. None of the authors have succeeded in solving these problems in their research designs or in their argumentations; even the awareness of the existence of these problems seems to be very limited. My conclusion is therefore that research on Swedishness has so far not been able to show that Swedishness exists.

  • Swedberg, Richard
    Stockholms universitet.
    Saint-Simons vision av ett enat Europa1994Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 31, nr 1, 21-40 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Saint-Simon's vision of a united Europe

    While there exists a considerable literature on Saint-Simon’s work as a whole, practically no research has been devoted to the theme of a united Europe in his writings. This essay traces this theme from his first to his last writings. While in the beginning of his career Saint-Simon emphasized that science would save Europe from its crisis and also unite it, he later emphasized the role of industry. In his famous pamphlet from 1814, De la réorganisationde la société européenne, Saint-Simon also suggested what the political structure of a united Europe may look like. What is remarkable about Saint-Simon’s mature vision of a united Europe is that Saint-Simon here brings together three separate ideas from the18th and 19th century: (1) Europe has to be reorganized if there is to be an end to all the wars; (2) Europe must get a government that is independent of the individual countries; and (3) industry will bind people together and play a key role in Europe’s unification. An effort is made - through Durkheim’s theory of collective representations - to explore the roots of Saint-Simon’s vision in the French Revolution and its aftermath. Paralells between Saint-Simon’s ideas and those of Jean Monnet are discussed in the last part of the article.

  • Hausmann, Simon
    et al.
    Tech Univ Munich, Dept Phys, Lehrstuhl Neutronenstreuung, James Franck Str 1, D-85748 Garching, Germany..
    Ye, Jingfan
    Tech Univ Munich, Dept Phys, Lehrstuhl Neutronenstreuung, James Franck Str 1, D-85748 Garching, Germany..
    Aoki, Toshihiro
    Univ Calif Irvine, Irvine Mat Res Inst, Irvine, CA 92697 USA..
    Zheng, Jian-Guo
    Univ Calif Irvine, Irvine Mat Res Inst, Irvine, CA 92697 USA..
    Stahn, Jochen
    Paul Scherrer Inst, Lab Neutron Scattering & Imaging, CH-5232 Villigen, Switzerland..
    Bern, Francis
    Univ Leipzig, Div Superconduct & Magnetism, D-04103 Leipzig, Germany..
    Chen, Binda
    Tech Univ Munich, Dept Phys, Lehrstuhl Neutronenstreuung, James Franck Str 1, D-85748 Garching, Germany..
    Autieri, Carmine
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori.
    Sanyal, Biplab
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori.
    Esquinazi, Pablo D.
    Univ Leipzig, Div Superconduct & Magnetism, D-04103 Leipzig, Germany..
    Böni, Peter
    Tech Univ Munich, Dept Phys, Lehrstuhl Neutronenstreuung, James Franck Str 1, D-85748 Garching, Germany..
    Paul, Amitesh
    Tech Univ Munich, Dept Phys, Lehrstuhl Neutronenstreuung, James Franck Str 1, D-85748 Garching, Germany..
    Atomic-scale engineering of ferroelectric-ferromagnetic interfaces of epitaxial perovskite films for functional properties2017Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 10734Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Besides epitaxial mismatch that can be accommodated by lattice distortions and/or octahedral rotations, ferroelectric-ferromagnetic interfaces are affected by symmetry mismatch and subsequent magnetic ordering. Here, we have investigated La-0.67 Sr-0.33 MnO3 (LSMO) samples with varying underlying unit cells (uc) of BaTiO3 (BTO) layer on (001) and (110) oriented substrates in order to elucidate the role of symmetry mismatch. Lattice mismatch for 3 uc of BTO and symmetry mismatch for 10 uc of BTO, both associated with local MnO6 octahedral distortions of the (001) LSMO within the first few uc, are revealed by scanning transmission electron microscopy. Interestingly, we find exchange bias along the in-plane [110]/[100] directions only for the (001) oriented samples. Polarized neutron reflectivity measurements confirm the existence of a layer with zero net moment only within (001) oriented samples. First principle density functional calculations show that even though the bulk ground state of LSMO is ferromagnetic, a large lattice constant together with an excess of La can stabilize an antiferromagnetic LaMnO3-type phase at the interface region and explain the experimentally observed exchange bias. Atomic scale tuning of MnO6 octahedra can thus be made possible via symmetry mismatch at heteroepitaxial interfaces. This aspect can act as a vital parameter for structure-driven control of physical properties.

  • Suolinna, Kirsti
    et al.
    Åbo Akademi.
    Lagerspetz, Olli
    Åbo Akademi.
    Två kriser inom finländsk sociologi1994Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 31, nr 1, 3-20 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Two crises in Finnish sociology

    The aim of the article is to compare two different institutional and paradigmatic crises in Finnish sociology. The first crisis occurred after World War II when the social sciences had to master new challenges posed by postwar Finnish society. At the University of Helsinkia new faculty was established which promoted modern social sciences. The earlier dominant Westermarck school lost its institutional position when the chairs where reserved for representatives of modern sociology. The Westermarck school’s scientific importance had diminished in the period between the two World Wars. Nevertheless the old Westermarckians got an opportunity to found the Westermarck Society as an interest group to promote Westermarck’s legacy. During the 1950s the Society gradually became dominated by representatives of the modern social sciences. The analysis presented in the article is based on protocols, letters and articles which document the old Westermarckians efforts to defend their scientific views and positions. The second crisis occurred during the 1960s and 1970s. The data consist of written documents but also interviews with sociologists at the universities of Helsinki, Turku and Tampere. The Westermarck Society as well as the Departments of Sociology at the Finnish universities were politicized during this period. By comparing the two periods of crises it is concluded that sociology is and was quite vulnerable to social and political influences. It can be argued that sociology as a science of society will always reflect ongoing political and social discourses and movements. However at times the involvement in these discourses may demand so much time and energy that it will hinder daily scientific routines and delay the achievement of results.

  • Udehn, Lars
    Uppsala universitet.
    Sociologisk Forskning 1994:11994Collection/Antologi (Fagfellevurdert)
  • Johannesson, Paul
    et al.
    Perjons, Erik
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Untangling the Web of Practices: Designing Information Systems in Context2017Inngår i: Systems, Signs & Actions, Vol. 10Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Practices are intertwined with each other, often in complex and unexpected ways. Therefore, the development of information systems artefacts does not only need to take into account the practices in which the artefacts are to be used, but also related practices. However, identifying and exploring these practices is a non-trivial task, which so far has not received much attention in the literature. Thus, the overall goal of the research presented in this paper is to provide a support for systematically addressing multiple, related practices in information systems design. The solution presented consists of a set of guidelines for context-aware analysis and design based on a classification of practice relationships, distinguishing between interconnected and resembling relationships. The former focus on exchanges of information as well as other resources, and they can be divided into management, asset, and input/output relationships. The latter consider practices that are similar to each other though they may reside in distinct areas or domains. The research presented is an example of design science, and the primary research methodology used is conceptual analysis. In order to preliminarily validate the result of the research, a demonstration has been carried out by applying the guidelines for analyzing an information system for schools.

  • Hull, Chris
    et al.
    Imperial Coll London, Blackett Lab, Prince Consort Rd, London SW7 AZ, England..
    Lindström, Ulf
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik. Imperial Coll London, Blackett Lab, Prince Consort Rd, London SW7 AZ, England..
    All (4,0): Sigma models with (4,0) off-shell supersymmetry2017Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 8, 129Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Off-shell (4, 0) supermultiplets in 2-dimensions are formulated. These are used to construct sigma models whose target spaces are vector bundles over manifolds that are hyperkahler with torsion. The off-shell supersymmetry implies that the complex structures are simultaneously integrable and allows us to write actions using extended superspace and projective superspace, giving an explicit construction of the target space geometries.

  • Parhizgar, Fariborz
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori. IPM, Inst Res Fundamental Sci, Sch Phys, Tehran 193955531, Iran..
    Black-Schaffer, Annica M.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori.
    Highly tunable time-reversal-invariant topological superconductivity in topological insulator thin films2017Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 9817Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We study time-reversal-invariant topological superconductivity in topological insulator (TI) thin films including both intra-and inter-surface pairing. We find a nontrivial topology for multiple different configurations. For intra-surface pairing a p-phase difference between the intra-surface pairing states is required. We show that in this case the resulting topological phase is highly tunable by both an applied electric field and varied chemical potential. For spin-singlet inter-surface pairing, a sign-changing tunnel coupling present in many TI thin films is needed, and again, the topology can be tuned by electric field or doping. Notably, we find that the required inter-surface pairing strength for achieving nontrivial topology can still be subdominant compared to the intra-surface pairing. Finally, for spin-triplet intersurface pairing we prove that the superconducting state is always topological nontrivial. We show that thin films of Cu-doped Bi2Se3 will likely host such spin-triplet inter-surface pairing. Taken together, these results show that time-reversal-invariant topological superconductivity is common in superconducting TI thin films and that the topological phase and its Kramers pair of Majorana edge modes is highly tunable with an applied electric field and varied chemical potential.

  • Disputas: 2018-01-29 10:00 Ka-Sal C (Sal Sven-Olof Öhrvik), Stockholm
    Wan, Qiansu
    KTH, Skolan för informations- och kommunikationsteknik (ICT).
    Life Cycle Assessment of Paper Based Printed Circuits2017Licentiatavhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Printed circuit boards have been massively manufactured and wildly used in all kinds of electronic devices during people’s daily life for more than thirty years since the last century. As a highly integrated device mainly consists of silicon base, an etched copper layer and other soldered components, massive production of printed circuit boards are considered to be environmentally unfriendly due to the wet chemical manufacturing mode and lack of recycling ability. On the other hand, the newly invented ink jet printing technology enables cost-effective manufacturing of flexible, thin and disposable electrical devices, which avoid acid etching process and lead to less toxic emissions into the environment. It is important to consider life cycle analysis for quantitative environmental impact evaluation and comparison of both printed circuit boards and printed electronics to enhance the sustainability of a new technology with product design and development. This thesis first reviews the current approaches to conventional and modern printing methods, as well as the state-of-the-art analysis of sustainability and environmental assessment methodologies. In the second part, a typical ink jet printed electronic device is introduced (an active flexible cable for wearable electrocardiogram monitoring). This active cable is designed for the interconnection between bio electrodes and central medical devices for bio signal transmission. As the active cable consists of five different metal transmission traces which are formed by printing conductive ink onto paper substrates, different shielding methods are investigated to ensure high quality bio signal transmission. Specifically, the results prove that passive shielding methods can significantly decrease the cross talk between different transmission traces, enabling the transmitting of bio signals for wearable ECG monitoring. This research also explores environmental issues related to printed electronics. For the full life cycle of printed electronics, we focused not only on quantitative environmental emissions to air, fresh water, sea and industrial soil, but also on resource consumption and impacts analysis. Finally, comparative environmental performance evaluation of traditional cables and ink jet printed active cables are made to examine the environmental impact and sustainability of both technologies, and the results show the strengths and weaknesses of each technology by analysis and assessment.

  • Amlinger, Lina
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi.
    Hoekzema, Mirthe
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi.
    Wagner, Gerhart E. H.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi.
    Koskiniemi, Sanna
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi.
    Lundgren, Magnus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi.
    Fluorescent CRISPR Adaptation Reporter for rapid quantification of spacer acquisition2017Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 10392Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    CRISPR-Cas systems are adaptive prokaryotic immune systems protecting against horizontally transferred DNA or RNA such as viruses and other mobile genetic elements. Memory of past invaders is stored as spacers in CRISPR loci in a process called adaptation. Here we developed a novel assay where spacer integration results in fluorescence, enabling detection of memory formation in single cells and quantification of as few as 0.05% cells with expanded CRISPR arrays in a bacterial population. Using this fluorescent CRISPR Adaptation Reporter (f-CAR), we quantified adaptation of the two CRISPR arrays of the type I-E CRISPR-Cas system in Escherichia coli, and confirmed that more integration events are targeted to CRISPR-II than to CRISPR-I. The f-CAR conveniently analyzes and compares many samples, allowing new insights into adaptation. For instance, we show that in an E. coli culture the majority of acquisition events occur in late exponential phase.

  • Bohm, Satu
    et al.
    Uppsala universitet, Universitetsbiblioteket.
    Byström, Karin
    Uppsala universitet, Universitetsbiblioteket.
    Nerelius, Petter
    Uppsala universitet, Universitetsbiblioteket.
    Thorn, Linda
    Uppsala universitet, Universitetsbiblioteket.
    Negotiating Change2017Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    Uppsala University Library is one of the largest in Sweden, with a wide range of specialties – old collections, digital repositories and current support to faculty and students. In the last 18 month the library has gone through a re-organization with the aim to make the library more united – one library. The change is among the most comprehensive that the 400-year-old library has undergone.

    The purpose of this paper is to describe how the library has developed ways of leading change by involving employees and managers at different levels in the change process. We focus on change management based on our experiences as change leaders. We will describe the major success factors and failures.

    The re-organization was done in several steps. Library units were merged and three processes introduced; Media and Collections, Study and Research Support and Information Services.  A Program Leader was assigned to coordinate the re-organization in the fall of 2015 and in January 2016 three Process Managers were added to lead and to work with the change processes.

    Within the processes, three working groups were established with the goal to present new workflows and services for digitization, working methods in library teaching and management of the virtual reference desk. Broad groups were set up with staff from all parts of the library. During the initial process a crucial point was to create a trusting and safe climate in the group to promote creativity and participation. Another key concept for success was to allow enough time for discussions and high sensitivity to when there were problems in the group that needed to be resolved, such as disagreement about a proposed solution. 

    The aim with the broad working groups was to reach a broad acceptance of the Changes, and during the discussions they developed a joint understanding of the need for change and for the chosen solution. This meant that the pace of change was slower than expected from start, but also that the changes at the end where easier to implement.

    Some of the resistance to change that appeard was due to different interpretations of the vision and reasons for re-organization. This shows that the understanding of the purposes of the changes also can influence the readiness for change. A success factor was to allow deeper discussions about the vision for the library and library services of the future.

    Negotiations about the changes was held at all levels of the organization. Problems, options and solutions in the process mapping were discussed by leaders and managers regularly.  To gain approval for the changes, all processes also had reference groups where new ideas and proposals were discussed. Information meetings for all staff were also arranged.

    Findings

    In anchoring change at all levels we believe negotiation is a key concept. Openness for discussion contributes to a feeling of being included amongst employees as well as management at all levels. Negotiating change guarantees quality and substantiated decisions from both a user perspective and an organizational perspective. Negotiation has also been a way of reflective practice around goals, effectiveness, working methods and leadership. It is not a fast track to results but we believe that anchoring change at all levels is a key concept for long-term success.

    Another success factor has been a joint change leadership between the Process Managers and the Program Leader. Leading change is a challenge even for an experienced leader. Step by step we created a strategy to lead the working groups through the change and created a joint change competency. 

    Conclusions

    The library has developed new ways of leading change by involving employees and managers at different levels in the change process.

    Changes can result in lot of tension and resistance in the organization and the new methods  have been an important part in avoiding this – to include concerned groups in the process and to take time to anchor the change.

  • Carreira, Bruno M.
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi. Univ Lisbon, Fac Ciencias, Ctr Ecol Evolut & Environm Changes cE3c, Lisbon, Portugal.
    Segurado, Pedro
    Univ Lisbon, Inst Super Agron, Ctr Estudos Florestais, Lisbon, Portugal..
    Laurila, Anssi
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Rebelo, Rui
    Univ Lisbon, Fac Ciencias, Ctr Ecol Evolut & Environm Changes cE3c, Lisbon, Portugal..
    Can heat waves change the trophic role of the world's most invasive crayfish?: Diet shifts in Procambarus clarkii2017Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, nr 9, e0183108Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In the Mediterranean basin, the globally increasing temperatures are expected to be accompanied by longer heat waves. Commonly assumed to benefit cold-limited invasive alien species, these climatic changes may also change their feeding preferences, especially in the case of omnivorous ectotherms. We investigated heat wave effects on diet choice, growth and energy reserves in the invasive red swamp crayfish, Procambarus clarkii. In laboratory experiments, we fed juvenile and adult crayfish on animal, plant or mixed diets and exposed them to a short or a long heat wave. We then measured crayfish survival, growth, body reserves and Fulton's condition index. Diet choices of the crayfish maintained on the mixed diet were estimated using stable isotopes (C-13 and N-15). The results suggest a decreased efficiency of carnivorous diets at higher temperatures, as juveniles fed on the animal diet were unable to maintain high growth rates in the long heat wave; and a decreased efficiency of herbivorous diets at lower temperatures, as juveniles in the cold accumulated less body reserves when fed on the plant diet. Heat wave treatments increased the assimilation of plant material, especially in juveniles, allowing them to sustain high growth rates in the long heat wave. Contrary to our expectations, crayfish performance decreased in the long heat wave, suggesting that Mediterranean summer heat waves may have negative effects on P. clarkii and that they are unlikely to boost its populations in this region. Although uncertain, it is possible that the greater assimilation of the plant diet resulted from changes in crayfish feeding preferences, raising the hypotheses that i) heat waves may change the predominant impacts of this keystone species and ii) that by altering species' trophic niches, climate change may alter the main impacts of invasive alien species.

  • Gliga, Anda R.
    et al.
    Karolinska Inst, Div Mol Toxicol, Stockholm, Sweden.;Karolinska Inst, Inst Environm Med, Div Biochem Toxicol, Stockholm, Sweden..
    Edoff, Karin
    Karolinska Inst, Dept Neurosci, Stockholm, Sweden..
    Caputo, Fanny
    Univ Roma Tor Vergata, Dept Biol, Rome, Italy.;Univ Roma Tor Vergata, Dept Chem Sci & Technol, Rome, Italy..
    Källman, Thomas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Blom, Hans
    Royal Inst Technol, Sci Life Lab, Solna, Sweden..
    Karlsson, Hanna L.
    Karolinska Inst, Inst Environm Med, Div Biochem Toxicol, Stockholm, Sweden..
    Ghibelli, Lina
    Univ Roma Tor Vergata, Dept Biol, Rome, Italy..
    Traversa, Enrico
    Univ Roma Tor Vergata, Dept Chem Sci & Technol, Rome, Italy.;Xi An Jiao Tong Univ, Int Res Ctr Renewable Energy, Xian, Shaanxi, Peoples R China..
    Ceccatelli, Sandra
    Karolinska Inst, Dept Neurosci, Stockholm, Sweden..
    Fadeel, Bengt
    Karolinska Inst, Div Mol Toxicol, Stockholm, Sweden..
    Cerium oxide nanoparticles inhibit differentiation of neural stem cells2017Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 9284Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Cerium oxide nanoparticles (nanoceria) display antioxidant properties and have shown cytoprotective effects both in vitro and in vivo. Here, we explored the effects of nanoceria on neural progenitor cells using the C17.2 murine cell line as a model. First, we assessed the effects of nanoceria versus samarium (Sm) doped nanoceria on cell viability in the presence of the prooxidant, DMNQ. Both particles were taken up by cells and nanoceria, but not Sm-doped nanoceria, elicited a temporary cytoprotective effect upon exposure to DMNQ. Next, we employed RNA sequencing to explore the transcriptional responses induced by nanoceria or Sm-doped nanoceria during neuronal differentiation. Detailed computational analyses showed that nanoceria altered pathways and networks relevant for neuronal development, leading us to hypothesize that nanoceria inhibits neuronal differentiation, and that nanoceria and Sm-doped nanoceria both interfere with cytoskeletal organization. We confirmed that nanoceria reduced neuron specific beta 3-tubulin expression, a marker of neuronal differentiation, and GFAP, a neuroglial marker. Furthermore, using super-resolution microscopy approaches, we could show that both particles interfered with cytoskeletal organization and altered the structure of neural growth cones. Taken together, these results reveal that nanoceria may impact on neuronal differentiation, suggesting that nanoceria could pose a developmental neurotoxicity hazard.

  • Malehmir, Alireza
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Geofysik.
    Maries, Georgiana
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Geofysik.
    Bäckstrom, Emma
    Nord Iron Ore AB, Ludvika, Sweden..
    Schön, Monika
    Nord Iron Ore AB, Ludvika, Sweden..
    Marsden, Paul
    Nord Iron Ore AB, Ludvika, Sweden..
    Developing cost-effective seismic mineral exploration methods using a landstreamer and a drophammer2017Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 10325Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    To be fully embraced into mineral exploration, seismic data require to be acquired fast, cheaper and with minimum environmental impacts addressing also the often brown-field highly noisy environment where these surveys are employed. Since 2013 and through a number of case studies, we have been testing a newly developed for urban environment, digital-based 240 m long, seismic landstreamer for mine planning and mineral exploration purposes. Here, we present a pilot study examining the potential of the streamer for deep targeting a known, down to approximately 850 m depth, iron-oxide mineralization in the Bergslagen mineral district of central Sweden. Combined streamer (100-3C-MEMS (micro-electromechanical system), 2-4 m spacing) and 75 wireless recorders (mixed 10 Hz and MEMS, 10 m spacing) were used. A Bobcat-mounted drophammer,500 kg, was used to generate the seismic signal. Within 4 days, approximately 3.5 km of seismic data using 2-10 m source and receiver spacing were acquired. Reflection data processing results clearly image the mineralization as a set of strong high-amplitude reflections and likely slightly extending beyond the known 850 m depth. This is encouraging and suggests such a cost-effective exploration method can be used in the area and elsewhere to delineate similar depth range iron-oxide deposits.

  • Li, Han
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Santiago-Kern, Rocio
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Jobs, Magnus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Bhattacharyya, Anirban
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Goryashko, Vitaliy
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Hermansson, Lars
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Gajewski, Konrad
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Lofnes, Tor
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Fransson, Kjell
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Ruber, Roger
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    First High Power Test of the ESS Double Spoke Cavity2017Rapport (Annet vitenskapelig)
    Abstract [en]

    The first double spoke cavity for ESS project was tested with high power in the HNOSS cryostat at FREIA Laboratory. This cavity is designed for 325.21MHz, a pulse mode with 14 Hz repetition rate, up to peak power of 360 kW. The qualification of the cavity package in a high power test, involved a spoke superconducting cavity, a fundamental power coupler, LLRF system and a RF station, represented an important verification before the module assembly. This report presents the test configuration, RF conditioning history and first high power performance of this cavity package.

  • Park, Wook Ha
    et al.
    Kyung Hee Univ, Dept Physiol, Coll Med, Seoul 02447, South Korea..
    Kang, Sora
    Kyung Hee Univ, Dept Physiol, Coll Med, Seoul 02447, South Korea..
    Lee, Hong Kyu
    Eulji Univ, Dept Internal Med, Coll Med, Seoul 01830, South Korea..
    Salihovic, Samira
    Orebro Univ, Sch Sci & Technol, MTM Res Ctr, SE-70182 Orebro, Sweden..
    van Bavel, Bert
    Orebro Univ, Sch Sci & Technol, MTM Res Ctr, SE-70182 Orebro, Sweden..
    Lind, P. Monica
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Arbets- och miljömedicin.
    Pak, Youngmi Kim
    Kyung Hee Univ, Dept Physiol, Coll Med, Seoul 02447, South Korea..
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Relationships between serum-induced AhR bioactivity or mitochondrial inhibition and circulating polychlorinated biphenyls (PCBs)2017Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 9383Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Metabolic syndrome and mitochondrial dysfunction have been linked to elevated serum levels of persistent organic pollutants (POPs). However, it is not clear which specific POPs contribute to aryl hydrocarbon receptor (AhR)-dependent bioactivity or inhibit mitochondrial function in human subjects. Here, we measured the cumulative bioactivity of AhR ligand mixture (AhR bioactivity) and the effects on mitochondrial function (ATP concentration) in recombinant Hepa1c1c7 cells incubated with raw serum samples obtained from 911 elderly subjects in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. Plasma concentrations of 30 POPs and plastic chemicals have previously been determined in the same PIVUS subjects. Linear regression analysis demonstrated that total toxic equivalence (TEQ) values and polychlorinated biphenyls (PCBs) were significantly correlated with AhR bioactivity (positively) and ATP concentration (negatively). Serum AhR bioactivities were positively associated with some PCBs, regardless of their dioxin-like properties, but only dioxin-like PCBs stimulated AhR bioactivity. By contrast, PCBs mediated a reduction in ATP content independently of their dioxin-like properties. This study suggests that AhR bioactivity and ATP concentrations in serum-treated cells may be valuable surrogate biomarkers of POP exposure and could be useful for the estimation of the effects of POPs on human health.

  • Hellstrand, Mats
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Competence Ctr Hlth, S-72189 Vasteras, Region Vastmanl, Sweden..
    Simonsson, Bo
    Competence Ctr Hlth, S-72189 Vasteras, Region Vastmanl, Sweden..
    Engström, Sevek
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin. Competence Ctr Hlth, S-72189 Vasteras, Region Vastmanl, Sweden..
    Nillson, Kent W.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås.
    Molarius, Anu
    Competence Ctr Hlth, S-72189 Vasteras, Region Vastmanl, Sweden.;Karlstad Univ, Dept Publ Hlth, Karlstad, Sweden..
    A health dialogue intervention reduces cardiovascular risk factor levels: a population based randomised controlled trial in Swedish primary care setting with 1-year follow-up2017Inngår i: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 17, 669Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The total number of cardiovascular (CVD) deaths accounted for almost a third of all deaths globally in 2013. Population based randomised controlled trials, managed within primary care, on CVD risk factor interventions are scarce. The aim of the study was to evaluate the effects of a health dialogue intervention in a primary care setting offered to a population at the age of 55 years, focusing on CVD risk factors. Methods: The study was performed in five primary health care centres in the county of Vastmanland, Sweden between April 2011 and December 2012. Men and women were randomly assigned to intervention (n = 440) and control groups (n = 440). At baseline, both groups filled in a health questionnaire and serum cholesterol, fasting plasma glucose, glycated haemoglobin (HbA1c), weight, height, waist (WC) and hip circumference, waist hip ratio (WHR) and systolic/diastolic blood pressure were measured. Intervention group attended a health dialogue, supported by a visualised health profile, with a possibility for further activities. Participation rates at baseline were 53% and 52% respectively. A 1-year follow-up was carried out. Results: The intervention group (n = 165) showed reductions compared to the control group (n = 177) concerning body mass index (BMI) (0.3 kg/m(2), p = .031), WC (2.1 cm, p <= .001) and WHR (. 002, p <= .001) at the 1-year follow-up. No differences between the intervention and control groups were found in other variables. Intervention group, compared to baseline, had reduced weight, BMI, WC, WHR, HbA1c, and diet, while the men in the control group had reduced their alcohol consumption. Conclusions: A health dialogue intervention at the age of 55 years, conducted in ordinary primary care, showed a moderate effect on CVD risk factor levels, in terms of BMI, WC and WHR.

  • Sund-Levander, Märtha
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för omvårdnad. Linköpings universitet, Medicinska fakulteten.
    Grodzinsky, Ewa
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Närsjukvården i västra Östergötland, Forsknings- och utvecklingsenheten för Närsjukvården i Östergötland. National Board Forens Med, Linkoping, Sweden.
    Variation in Normal Ear Temperature2017Inngår i: The American journal of surgery, ISSN 0002-9629, E-ISSN 1538-2990, Vol. 354, nr 4, 370-378 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Variation in baseline ear temperature, taken in the unadjusted mode, has yet to be established in different age groups. Because normal body temperatures show large variations, the same may be expected for increased temperatures in fever. The aims were to study variations in normothermic body temperatures measured with an ear thermometer and to determine differences between actual and perceived body temperature during a febrile episode (referred to as difftemp) in apparently healthy children and adults. Methods: Ear temperature was measured once in 2,006 individuals (61.7% females): 683 children aged 2 and 4 years, 492 adolescents aged 10-18 years, 685 adults aged 19-65 years and 146 elderly aged 66-89 years. Difftemp was estimated as the difference between the individuals ear body temperature, measured in the present study, and the respondents reported temperature when feverish. Results: Mean ear temperature was 36.4 +/- 0.6 degrees C overall and in the child and adult groups. In adolescents, it was 36.5 +/- 0.5 degrees C, and in elderly, 36.1 +/- 0.5 degrees C. Temperature in men was 36.3 +/- 0.6 degrees C, and in women, 36.5 +/- 0.5 degrees C. Difftemp was 1.1 +/- 0.7 degrees C in adolescents, 1.5 +/- 0.7 degrees C in children and adults, and 1.6 +/- 0.7 degrees C in those amp;gt; 65 years. Conclusions: Ear body temperature is lower than traditionally reported and differs with age and sex. An individual difftemp of 1.0-1.5 degrees C along with malaise might indicate fever.

  • Vu, Mai Trang
    Faculty of English Teacher Education, University of Languages and International Studies, Vietnam National University, Hanoi.
    Some thoughts on being trained as a trainer of primary teachers2012Inngår i: The Teacher Trainer Journal, ISSN 0951-7626, Vol. 26, nr 2, 7-8 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This is a reflective text on my experiences being trained as a trainer of primary English teachers. The text is an entry to ‘My journey as a primary trainer of teachers’, about how participants developed professionally as a trainer and how they have applied the skills learned on a training-of-trainer course. The course was part of British Council's Access English project  that supported the development of national English Language Teaching at both primary and secondary levels in East Asian countries.

  • Engman, Linnea
    et al.
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Flink, Ida
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Thomtén, Johanna
    Center for Health and Medical Psychology (CHAMP), Örebro University, Sweden.
    Linton, Steven J.
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Avoiding or enduring painful sex?: A longitudinal study of coping patterns and sexual function in women with vulvovaginal pain2017Inngår i: SSTAR (Society for Sex Therapy and Research) 42nd annual meeting, 2017Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Introduction: Recurring pain in the vulvar- or vaginal region induced by touch or pressure is common, affecting between 10-28% of women in reproductive age (e.g., Harlow et al., 2014). In addition to evident negative effects on sexual aspects such as frequency of sexual activity, sexual satisfaction and sexual function (for a review see Bergeron et al., 2015), vulvovaginal pain has an impact on women’s overall quality of life (Arnold et al., 2006). Despite these extensive consequences little is known about how women with vulvovaginal pain actually cope with sexual activities and the subsequent pain, and how their coping may affect the pain experience and sexual function over time. While avoidance (of pain associated activities) seem to be a commonly used strategy (for a review see Thomtén and Linton, 2013) amongst women with vulvovaginal pain, there is also evidence of endurance (of sexual activity despite pain) as a prevalent strategy (Brauer et al., 2014; Elmerstig et al., 2013).

     

    Method: The study used questionnaire data from female university students between 18 and 35 years old, with two measurement points of five months apart. Women who reported experiencing recurring vulvovaginal pain during the last six months, and who responded at both measurement points constitute the sample of the study (N=117). First, multiple regression analysis was executed to test whether avoidance and endurance coping had a predictive value of sexual function beyond the pain experience in itself. Then, cluster analyses based on the respondent’s answers to the CHAMP Sexual Pain Coping Scale (CSPCS) were performed at both time points. Finally, common pathways over time was investigated to explore whether the same coping was used at baseline and follow-up.

     

    Results: The multiple regression model exploring if pain, avoidance and endurance at baseline predicted sexual function at follow-up was significant, explaining 25% of the variance (F(2, 90) = 10.22, p < .001). Avoidance at baseline was the only significant predictor in the model, explaining unique variance of sexual function over time. The cluster analyses at baseline and follow up resulted in four distinct clusters respectively; Low scores, Avoidance, Endurance and High scores. The common pathways analyses, exploring typical pathways of change, revealed high stability within the clusters over time meaning that it was common for individuals in all clusters to use the same patterns of coping at both measurement points.

     

    Discussion: The results of the study further manifests findings from earlier research while also making an important attribution in quantifying coping strategies in relation to vulvovaginal pain. The study reveals a strong association between vulvovaginal pain and how women cope with sexual activities, the stability of the use of coping over time, as well as the connection between coping and sexual function.

     

    Utility/Limitations/Risks: Further knowledge about the relationship between coping and vulvovaginal pain will provide important theoretical and clinical implications regarding the development of the pain as well as potential clinical interventions.

     

    Behavioral learning objectives:

    After attending this poster presentation, the participants will be able to:

    1. Recognize the importance of avoidance coping in relation to sexual function

    2. Discuss the use of avoidance and endurance coping as a combined pattern

    3. Identify the stability of the use of coping patterns over time

     

    References:

    Arnold, L. D., Bachmann, G. A., Kelly, S., Rosen, R., & Rhoads, G. G. (2006). Vulvodynia: characteristics and associations with co-morbidities and quality of life. Obstetrics and gynecology, 107(3), 617.

     

    Bergeron, S., Corsini-Munt, S., Aerts, L., Rancourt, K., & Rosen, N. O. (2015). Female sexual pain disorders: a review of the literature on etiology and treatment. Current Sexual Health Reports, 7(3), 159-169.

     

    Brauer, M., Lakeman, M., Lunsen, R., & Laan, E. (2014). Predictors of task‐persistent and fear‐avoiding behaviors in women with sexual pain disorders. The journal of sexual medicine, 11(12), 3051-3063.

     

    Elmerstig, E., Wijma, B., & Swahnberg, K. (2013). Prioritizing the partner’s enjoyment: a population-based study on young Swedish women with experience of pain during vaginal intercourse. Journal of Psychosomatic Obstetrics & Gynecology, 34(2), 82-89.

     

    Harlow, B. L., Kunitz, C. G., Nguyen, R. H., Rydell, S. A., Turner, R. M., & MacLehose, R. F. (2014). Prevalence of symptoms consistent with a diagnosis of vulvodynia: population-based estimates from 2 geographic regions. American journal of obstetrics and gynecology, 210(1), 40-e1.

     

    Thomtén, J., & Linton, S. J. (2013). A psychological view of sexual pain among women: applying the fear-avoidance model. Women’s Health, 9(3), 251-263.

     

  • Berghoff, Bork A.
    et al.
    Justus Liebig Univ, Inst Mikrobiol & Mol Biol, Giessen, Germany..
    Karlsson, Torgny
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik.
    Källman, Thomas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Wagner, Gerhart E. H.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi.
    Grabherr, Manfred
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    RNA-sequence data normalization through in silico prediction of reference genes: the bacterial response to DNA damage as case study2017Inngår i: BioData Mining, ISSN 1756-0381, E-ISSN 1756-0381, Vol. 10, 30Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Measuring how gene expression changes in the course of an experiment assesses how an organism responds on a molecular level. Sequencing of RNA molecules, and their subsequent quantification, aims to assess global gene expression changes on the RNA level (transcriptome). While advances in high-throughput RNA-sequencing (RNA-seq) technologies allow for inexpensive data generation, accurate post-processing and normalization across samples is required to eliminate any systematic noise introduced by the biochemical and/or technical processes. Existing methods thus either normalize on selected known reference genes that are invariant in expression across the experiment, assume that the majority of genes are invariant, or that the effects of up-and down-regulated genes cancel each other out during the normalization.

    Results: Here, we present a novel method, moose(2), which predicts invariant genes in silico through a dynamic programming (DP) scheme and applies a quadratic normalization based on this subset. The method allows for specifying a set of known or experimentally validated invariant genes, which guides the DP. We experimentally verified the predictions of this method in the bacterium Escherichia coli, and show how moose(2) is able to (i) estimate the expression value distances between RNA-seq samples, (ii) reduce the variation of expression values across all samples, and (iii) to subsequently reveal new functional groups of genes during the late stages of DNA damage. We further applied the method to three eukaryotic data sets, on which its performance compares favourably to other methods. The software is implemented in C++ and is publicly available from http://grabherr.github.io/moose2/.

    Conclusions: The proposed RNA-seq normalization method, moose(2), is a valuable alternative to existing methods, with two major advantages: (i) in silico prediction of invariant genes provides a list of potential reference genes for downstream analyses, and (ii) non-linear artefacts in RNA-seq data are handled adequately to minimize variations between replicates.

  • Hojberg, Anker Lajer
    et al.
    Hansen, Anne Lausten
    Wachniew, Przemyslaw
    Zurek, Anna J.
    Virtanen, Seija
    Arustiene, Jurga
    Strömqvist, Johan
    SMHI, Forskningsavdelningen, Hydrologi.
    Rankinen, Katri
    Refsgaard, Jens Christian
    Review and assessment of nitrate reduction in groundwater in the Baltic Sea Basin2017Inngår i: JOURNAL OF HYDROLOGY-REGIONAL STUDIES, ISSN 2214-5818, Vol. 12, 50-68 s.Artikkel i tidsskrift (Fagfellevurdert)
  • Recensioner1994Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 31, nr 2, 86-109 s.Artikkel, omtale (Annet vitenskapelig)
  • Zetterberg, Hans L
    City-universitetet, Stockholm.
    Samhällssfärerna i historiens ljus1994Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 31, nr 2, 63-85 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Societal spheres in the light of history

    A division of society into statecraft, economy, and civil society is found in Plato’s Republic. Its theoretical base is the differentiated and sometimes contradictory norms for these spheres. The mainstream of European structuration is traced from the ’two swords’ - state and church - that structured western European society in the Middle Ages to the six societal spheres (or cardinal institutions) of society - the economy, government, science, religion, ethics, and art - that are visible today. Each maintain a large measure of independence (Weber’s Eigengesetzlichkeit). Each is dependent on a special type of freedom: civic liberties, free trade, academic freedom, religious toleration, the right to follow one’s conscience, artistic license. The paper pauses in this differentiation process at special junctures: the English revolution, the emergence of the Latin American and North American societies, the evolution of modem society as an underpinning of democracy, the emergence of the European Union, and the post-Communist Central and Eastern Europe.

  • Bergström, Erik
    Högskolan i Skövde, Institutionen för informationsteknologi. Högskolan i Skövde, Forskningscentrum för Informationsteknologi.
    Thesis Proposal: A Method for Information Classification2017Rapport (Annet vitenskapelig)
    Abstract [en]

    In the highly digitalized world in which we live today, information and information systems have become key assets to organizations.  These assets need to be managed properly because it is difficult to safeguard assets that an organization does not know exist and does not know the value they offer. In an Information Security Management System (ISMS), asset management is an important activity as it aims at identifying, assigning ownership and adding protection to information assets. Within asset management, one activity is information classification that has the objective to ensure that information receives an appropriate level of protection in accordance with its importance to the organization. In practice, this is usually done using a classification scheme, and the result is handled as input to the risk analysis. Information classification is a well-known practice for all kind of organizations, both in the private and public sector, and is included in different variants in standards such as ISO/IEC 27002, COBIT and NIST-SP800.

    However, information classification has received little attention from academia, and many organizations are struggling with the implementation. Little is known about the reasons behind why it is problematic, and how to address such issues. Furthermore, the existing methods, described in, e.g., standards do not provide a coherent and systematic approach to information classification. The short descriptions in standards, and literature alike, leave out important aspects needed for many to adopt any kind of information classification. For instance, there is a lack of detailed descriptions regarding (1) overview of procedures, and concepts, (2) which roles are involved in the classification, and how they interact, (3) how to tailor the method for different situations and (4) a framework that structures and guides the classification. If information classification is not implemented in an organization, the organization might not know what information they possess, what the value of the information is, but even if it is implemented, an unclear approach can lead to information being under or overvalued, which, in turn, lead to under or overprotected information.

    This thesis aims to increase the applicability of information classification by devising a method for information classification in ISMS that draws from established standards and practice. In order to address this aim, a Design Science Research (DSR) study has been performed in five cycles. The contributions so far include an identification of issues and enablers for information classification and propose a component-based method for information classification. Furthermore, eighth design principles underpinning an information classification method are presented. Additionally, an outline for further research is provided, where the objectives are to further develop the method by addressing the context around information classification (the risk analysis and security controls), and by adding usage views to the method. Finally, a security declaration as an addition to the information classification method is outlined as a complement for tying security controls to the information classification scheme.