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  • Steen-Hansen, Anne
    et al.
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Storesund, Karolina
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Sesseng, Christian
    Metode for evaluering av branner2015Report (Other academic)
    Abstract [no]

    Denne rapporten beskriver en enkel metode som kan anvendes ved mindre omfattende evalueringer av branner. Med metode menes her en systematikk for gjennomføring av evalueringer. En mindre omfattende evaluering vil være en gjennomgang der det enten er få forhold ved brannen som skal undersøkes, eller der situasjonen er relativt oversiktlig. Metoden er deretter anvendt på en brann i et sykehjem. Evalueringen av denne hendelsen er ikke fullstendig gjennomført, men fungerer som et eksempel på hvordan metoden kan brukes.

  • Majano, Sara Benitez
    et al.
    London Sch Hyg & Trop Med, Canc Survival Grp, Dept Noncommunicable Dis Epidemiol, London, England.
    Di Girolamo, Chiara
    London Sch Hyg & Trop Med, Canc Survival Grp, Dept Noncommunicable Dis Epidemiol, London, England;Univ Bologna, Dept Med & Surg Sci, Alma Mater Studiorum, Bologna, Italy.
    Rachet, Bernard
    London Sch Hyg & Trop Med, Canc Survival Grp, Dept Noncommunicable Dis Epidemiol, London, England.
    Maringe, Camille
    London Sch Hyg & Trop Med, Canc Survival Grp, Dept Noncommunicable Dis Epidemiol, London, England.
    Guren, Marianne Gronlie
    Oslo Univ Hosp, Dept Oncol, Oslo, Norway;Oslo Univ Hosp, KG Jebsen Colorectal Canc Res Ctr, Oslo, Norway.
    Glimelius, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Iversen, Lene Hjerrild
    Aarhus Univ Hosp, Dept Surg, Aarhus, Denmark;Danish Colorectal Canc Grp, Aarhus, Denmark.
    Schnell, Edrun Andrea
    Canc Registry Norway, Data Delivery Unit, Oslo, Norway.
    Lundqvist, Kristina
    Umea Univ, Oncol, Dept Radiat Sci, Umea, Sweden;Reg Canc Ctr Norr, Umea, Sweden.
    Christensen, Jane
    Danish Canc Soc, Canc Control Documentat & Qual, Copenhagen, Denmark.
    Morris, Melanie
    London Sch Hyg & Trop Med, Dept Hlth Serv Res & Policy, London, England.
    Coleman, Michel P.
    London Sch Hyg & Trop Med, Canc Survival Grp, Dept Noncommunicable Dis Epidemiol, London, England.
    Walters, Sarah
    London Sch Hyg & Trop Med, Dept Populat Hlth, London, England.
    Surgical treatment and survival from colorectal cancer in Denmark, England, Norway, and Sweden: a population-based study2019In: The Lancet Oncology, ISSN 1470-2045, E-ISSN 1474-5488, Vol. 20, no 1, p. 74-87Article in journal (Refereed)
    Abstract [en]

    Background Survival from colorectal cancer has been shown to be lower in Denmark and England than in comparable high-income countries. We used data from national colorectal cancer registries to assess whether differences in the proportion of patients receiving resectional surgery could contribute to international differences in colorectal cancer survival. Methods In this population-based study, we collected data from all patients aged 18-99 years diagnosed with primary, invasive, colorectal adenocarcinoma from Jan 1, 2010, to Dec 31, 2012, in Denmark, England, Norway, and Sweden, from national colorectal cancer registries. We estimated age-standardised net survival using multivariable modelling, and we compared the proportion of patients receiving resectional surgery by stage and age. We used logistic regression to predict the resectional surgery status patients would have had if they had been treated as in the best performing country, given their individual characteristics. Findings We extracted registry data for 139457 adult patients with invasive colorectal adenocarcinoma: 12958 patients in Denmark, 97466 in England, 11450 in Norway, and 17583 in Sweden. 3-year colon cancer survival was lower in England (63.9%, 95% CI 63.5-64.3) and Denmark (65.7%, 64.7-66.8) than in Norway (69.5%, 68.4-70.5) and Sweden (72.1%, 71.2-73.0). Rectal cancer survival was lower in England (69.7%, 69.1-70.3) than in the other three countries (Denmark 72.5%, 71.1-74.0; Sweden 74.1%, 72.7-75.4; and Norway 75.0%, 73.1-76.8). We found no significant differences in survival for patients with stage I disease in any of the four countries. 3-year survival after stage II or III rectal cancer and stage IV colon cancer was consistently lower in England (stage II rectal cancer 86.4%, 95% CI 85.0-87.6; stage III rectal cancer 75.5%, 74.2-76.7; and stage IV colon cancer 20.5%, 19.9-21.1) than in Norway (94.1%, 91.5-96.0; 83.4%, 80.1-86.1; and 33.0%, 31.0-35.1) and Sweden (92.9%, 90.8-94.6; 80.6%, 78.2-82.7; and 23.7%, 22.0-25.3). 3-year survival after stage II rectal cancer and stage IV colon cancer was also lower in England than in Denmark (stage II rectal cancer 91.2%, 88.8-93.1; and stage IV colon cancer 23.5%, 21.9-25.1). The total proportion of patients treated with resectional surgery ranged from 47803 (68.4%) of 69867 patients in England to 9582 (81.3%) of 11786 in Sweden for colon cancer, and from 16544 (59.9%) of 27599 in England to 4106 (70.8%) of 5797 in Sweden for rectal cancer. This range was widest for patients older than 75 years (colon cancer 19078 [59.7%] of 31946 patients in England to 4429 [80.9%] of 5474 in Sweden; rectal cancer 4663 [45.7%] of 10195 in England to 1342 [61.9%] of 2169 in Sweden), and the proportion of patients treated with resectional surgery was consistently lowest in England. The age gradient of the decline in the proportion of patients treated with resectional surgery was steeper in England than in the other three countries in all stage categories. In the hypothetical scenario where all patients were treated as in Sweden, given their age, sex, and disease stage, the largest increase in resectional surgery would be for patients with stage III rectal cancer in England (increasing from 70.3% to 88.2%). Interpretation Survival from colon cancer and rectal cancer in England and colon cancer in Denmark was lower than in Norway and Sweden. Survival paralleled the relative provision of resectional surgery in these countries. Differences in patient selection for surgery, especially in patients older than 75 years or individuals with advanced disease, might partly explain these differences in international colorectal cancer survival.

  • Sesseng, Christian
    et al.
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Reitan, Nina Kristine
    Fjær, Sindre
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Kartlegging av gasskonsentrasjoner, effekt av dødluftsrom og effekt av alternativt deteksjonsprinsipp ved ulmebrann2015Report (Other academic)
    Abstract [no]

    Åtte av ti som omkommer i brann dør i hjemmet. Det er stadfestet at røykvarslere redder liv, noe som understreker hvor viktig det er at alle hjem har fungerende røykvarsler. I Norge er det krav om at fungerende røykvarsler er installert i alle boliger, og det er også gitt anbefalinger om deteksjonsprinsipp og plassering av røykvarslere. Det er anbefalt å benytte optiske røykvarslere fremfor ioniske, og at disse monteres i tak, utenfor dødluftsrom (nær vegg). I denne studien er det utført ti forsøk med ulmebrann i et testrom innredet med en seng for å: • undersøke om røykdetektorer med CO-sensor kan varsle beboer på et tidligere tidspunkt enn optiske detektorer, og følgelig øke sjansene for evakuering. • kartlegge nivået av giftige gasser i et rom hvor ulmebrann oppstår, og undersøke om grenseverdiene for forgiftning er overskredet når en tradisjonell, optisk røykvarsler går til alarm. • undersøke om røykdetektorer som er plassert i dødluftsrom reagerer tregere enn detektorer som er plassert i henhold Norsk brannvernforenings anbefalinger.

  • Strömgren, Elisabeth
    The Nordic Museum.
    Broderade hänmgkläden från Blekinge1950In: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1950, p. 163-174Chapter in book (Other academic)
  • Storesund, Karolina
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Steen-Hansen, Anne
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Bøe, Andreas G.
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Stolen, Reidar
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Gjøsund, Gudveig
    NTNU Norwegian University of Science and Technology, Norway.
    Halvorsen, Kristin
    NTNU Norwegian University of Science and Technology, Norway.
    Almklov, Petter G.
    NTNU Norwegian University of Science and Technology, Norway.
    Rett tiltak på rett sted: Forebyggende og målrettede tekniske og organisatoriske tiltak mot dødsbranner i risikogrupper2015Report (Other academic)
    Abstract [no]

    Personer som på ulike måter kan kategoriseres som sårbare, er overrepresentert i dødsbrannstatistikken. Derfor er det viktig å finne fram til effektive og målrettede tiltak som kan forhindre framtidige dødsbranner der personer som tilhører det som omtales som sårbare grupper er involvert. I rapporten brukes en helhetlig analytisk tilnærming som skal fange opp mangfoldet av dimensjoner som kan påvirke forebygging av dødsbrann, og hvordan disse virker i samspill med hverandre. Prosjektet har operert med en forståelse av sårbarhet som inkluderer både det fysiske miljøet, de menneskelige behovene og de sosiale og organisatoriske omgivelsene. En del av rapporten retter seg mot tekniske løsninger som kan brukes for å forbedre brannsikkerheten til sårbare grupper. Det har vært et mål å finne ut hvordan organisatoriske og tekniske tiltak kan brukes og ses i sammenheng, og hvordan tekniske tiltak kan implementeres, vurderes og dokumenteres.

  • Stensaas, Jan P.
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Sesseng, Christian
    Kartlegging av forskningsstatus innen brannetterforskning2015Report (Other academic)
    Abstract [no]

    I dette prosjektet er det gjennomført et litteraturstudium der vi har kartlagt forskningsstatus innen utvalgte tema innenfor brannetterforskning. Det er gjennomført søk i aktuelle litteraturdatabaser for nasjonale og internasjonale publikasjoner, og i annen relevant faglitteratur som bøker og rapporter. Utvalgte relevante forskningsinstitusjoner og fagmiljøer er også kontaktet for å undersøke status innenfor de aktuelle temaene. Følgende prioriterte emner er undersøkt: • Brennbare væsker • Antennelse ved gnister, glør og varme partikler • Batterier • Selvantennelse

  • Sesseng, Christian
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Fjær, Sindre
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Mapping of gas concentrations, effect of deadair space and effect of alternative detection technology in smouldering fires2016Report (Other academic)
    Abstract [en]

    Eight out of ten fire-related fatalities occur in dwellings. It is a fact that smoke detectors save lives, which emphasizes the importance of every home having a functioning smoke detector. In Norway, smoke detectors in dwellings are mandatory, and recommendations on which detector technology to use and the position of the detectors are given. Smoke detectors should be installed on the ceiling, outside of dead-air space (close to walls). In this study, ten smouldering fire experiments have been conducted to: • investigate if smoke detectors with CO sensing can alert residents at an earlier stage than photoelectric smoke detectors, consequently increasing chances of egress and survival for a sleeping person. • measure concentrations of toxic gases in a room where a smouldering fire occurs and investigate if tenability limits are exceeded when n photoelectric smoke detector is activated. • investigate if smoke detectors placed within dead-air space are activated at a later stage than smoke detectors placed according to the recommendations.

  • Bengtsson, Bengt
    The Nordic Museum.
    Christian Hammers skissböcker1950In: Fataburen: Nordiska museets och Skansens historia, Stockholm: Nordiska museets förlag, 1950, p. 153-162Chapter in book (Other academic)
  • Storesund, Karolina
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Steen-Hansen, Anne
    Optisk varsling – Veiledningstekst2016Report (Refereed)
    Abstract [no]

    Denne rapporten er utarbeidet på oppdrag fra Direktoratet for byggkvalitet (DiBK) og Direktoratet for samfunnssikkerhet og beredskap (DSB). Prosjektet har bakgrunn i at DiBK har mottatt et endringsforslag til eksisterende tekst i VTEK § 11-12, annet ledd annet ledd bokstav a, preaksepterte ytelser punkt 4. Teksten omhandler optisk varsling som en del av et brannalarmanlegg.

  • Sesseng, Christian
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Evergren, Franz
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Brannsikkerhet ved bruk av gassbeholdere i bygg2018Report (Refereed)
    Abstract [no]

    Denne rapporten er utarbeidet på oppdrag fra Direktoratet for samfunnssikkerhet og beredskap (DSB). DSB har bedt RISE Fire Research om å bistå med evalueringer knyttet til bruken av gassbeholdere ved serveringssteder, overnattingssteder og forsamlingslokaler.

  • Chien, Yu-Chuan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Pan, Ruijun
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Inorganic Chemistry.
    Nyholm, Leif
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Inorganic Chemistry.
    Brandell, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Lacey, Matthew
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Electrochemical Analysis of the Modified Separators for Li-S Batteries2018Conference paper (Other academic)
    Abstract [en]

    The lithium-sulfur system is one of the potential energy storage technologies of the next generation due to the high theoretical specific capacity (1672 mAh/g), abundance and nontoxicity of sulfur [1]. However, there are still challenges yet to be overcome, one of which is the ‘polysulfide shuttle’ [1]. In order to address this issue, several modifications of the separators have been proposed. For example, longer cycle life, higher Coulombic efficiency and higher specific capacities have been reported with metal oxide coatings [2] and conductive interlayers [3,4] on the separators. Performance improvements in one or more of these properties have been ascribed to a suppression of polysulfide transport across the separator, even though this has not always been correlated with the difference in electrochemistry.

     

    In this work, the Intermittent Current Interruption (ICI) method [5] is applied to monitor the evolution of internal resistance of Li-S cells with different separators during repeated charge and discharge. Cells with different separators exhibit significant differences in resistance as a function of state-of-charge in the initial cycles, as shown in the figure.  Complemented by self-discharge tests and impedance spectroscopy at selected states of charge, the roles of the interlayers in the system can be further interpreted electrochemically. This work aims to associate the electrochemical properties of the interlayers to their corresponding microstructural counterparts, which can in turn facilitate further development of the interlayer materials.

     

    Figure: Internal resistance of cells vs specific charge for Li-S cells with different separators (Zero charge indicates the fully charged state.) for the 2nd, 5th and 10th cycles at C/10 rate.

     

    References:

    [1]         S. Urbonaite, T. Poux, P. Novák, Adv. Energy Mater. 5 (2015) 1–20.

    [2]         Z. Zhang, Y. Lai, Z. Zhang, K. Zhang, J. Li, Electrochim. Acta 129 (2014) 55–61.

    [3]         H. Yao, K. Yan, W. Li, G. Zheng, D. Kong, Z.W. Seh, V.K. Narasimhan, Z. Liang, Y. Cui, Energy Environ. Sci. 7 (2014) 3381–3390.

    [4]         J. Balach, T. Jaumann, M. Klose, S. Oswald, J. Eckert, L. Giebeler, Adv. Funct. Mater. 25 (2015) 5285–5291.

    [5]         M.J. Lacey, K. Edström, D. Brandell, Chem. Commun. 51 (2015) 16502–16505.

  • Hjalmarsson-Jordanius, Anders
    et al.
    RISE - Research Institutes of Sweden, ICT, Viktoria. University of Borås, Sweden.
    van Amelsfort, Dirk
    RISE - Research Institutes of Sweden, ICT, Viktoria.
    Dolins, Sigma
    RISE - Research Institutes of Sweden, ICT, Viktoria.
    Rewarding Sustainable Transportation Choices: Impacts of App-Based Outreach and Incentive Distribution2017Conference paper (Refereed)
    Abstract [en]

    What is the most effective way to influence travellers’ behaviour using positive incentives andrewards? The European Project EMPOWER implements a diverse strategy to significantly reducethe use of conventionally fuelled vehicles (CFV) in urban areas, through influencing the behaviourof car drivers. The aim is to incentivise users of CFVs to change their behaviour with positiveincentives, thus rewarding them, rather than penalizing them, for making sustainable transportationchoices. This paper targets the setup and effects of the experiments performed in Sweden,including an expansion of the service from the main Living Lab in Gothenburg to other cities inSweden, where users are incentivized through a smartphone app called SMARTiSverige. In thetwo-step experiment presented in this paper, we used the app to collect data to develop challenges,communicate personalized challenges to users, and communicate the points achieved if thechallenges are completed successfully. Digital and physical rewards were then distributed to theusers as a part of the complete scheme system. In addition to an account of the experiment andachieved results, this paper also discusses the implication of this research on the existing body ofknowledge regarding incentives, and elaborates on how the lessons learned from this Living Labcould be used to scale up services in future sites for rewarding sustainable transport choices andimpacting the use of CFVs.

  • Wallin, Sigurd
    The Nordic Museum. Stiftelsen Nordiska museet.
    Linnéminnen i Nordiska museet1950In: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1950, p. 141-152Chapter in book (Other academic)
  • Granlund, John
    The Nordic Museum.
    Något om laxfisket i Lidsforsen: apropå ett kulturminnesmärke i Prästbäcken1950In: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1950, p. 119-140Chapter in book (Other academic)
  • Public defence: 2019-03-01 10:00 Kollegiesalen, Stockholm
    Paulraj, Alagar Raj
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemical Engineering, Process Technology.
    Studies on Rechargeable Fe-air electrodes in Alkaline electrolyte2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Energy storage system is an important component in the energy system based on variable renewable energy sources into the grid. Energy storage system could contribute to decarbonization, energy security, offset the demand and supply of the electricity sector, especially for the electric grid. These can be either mechanical, electrochemical, chemical, electromagnetic or thermal devices. The most important functional characteristics of an energy storage system are capital cost, roundtrip efficiency, energy and power rating, response times and cycle life. Electrochemical energy storage systems (EES) have the following edge over the other systems: fast response time, relatively short duration of storage, size, high efficiency, a decentralized installation which is closer to generation or consumption site.

    The focus of this thesis is on the development of cost-effective iron anode materials and electrocatalytic air electrodes for Fe-air batteries that potentially could become as an energy storage system. Iron-based systems are attractive due to their safety, cheapness, non-toxicity and ubiquitous availability of materials. However, both the anode and cathode parts have numerous drawbacks that need to be addressed. The anode exhibits poor charge efficiency, rate capability and low capacity utilization while the cathode has sluggish kinetics, poor activity, structural stability and the numbers of active non-noble metal catalysts are limited.

    This work utilized Cu and Sn-doped iron nanomaterials and different additives (Bi2S3, CNT, LiOH) to enhance the performance of the iron electrode. The performance of the electrodes were evaluated using the charge/discharge cycling, rate capability, cyclic voltammetry (CV), galvanostatic and potentiodynamic polarization measurements, in operando charging measurements combined with mass spectrometry. The fresh and cycled electrodes and powders were characterized by ex-situ XRD, BET, SEM, TEM , XPS and Raman spectroscopy. The most striking results are the prevention of nanoparticle agglomeration, increased charging efficiency (80-91%), effect of Cu and Sn dopants on specific capacity (367-603 mAh g-1) and improved performance of the electrodes at high charge current densities.

    In the subsequent air electrode part, non-precious metal La-doped CaMnOx, nano Co3O4 and NiFeOX electrocatalysts were synthesized using co-precipitation and hydrothermal methods. Both the single and mixed catalysts were used as bi-functional catalysts for oxygen reduction and evolution reactions (ORER). The catalysts were characterized by XRD, SEM, TEM, BET, Raman and XPS. The electrocatalytic activity and stability were assessed in alkaline solutions on gas diffusion electrodes and glassy carbon electrode by linear sweep voltammetry (LSV), CV and rotating disk electrode (RDE). Furthermore, the mixed catalyst and NiFeOX showed excellent bifunctional performance such as high activity and stability achieved by the hybridization of the two catalysts and the effect of catalyst loading on the electrocatalytic performance. These findings can help to develop a cost-effective material for Fe-air batteries.

  • Persson, Mattias
    et al.
    RISE - Research Institutes of Sweden, Safety and Transport, Measurement Science and Technology.
    Sandels, Claes
    RISE - Research Institutes of Sweden, Safety and Transport, Measurement Science and Technology.
    Nilsson, Andreas
    RISE - Research Institutes of Sweden, Safety and Transport, Measurement Science and Technology.
    Dataanalys och avancerade algoritmer : Möjligheter med utökad mätinfrastruktur2018Report (Other academic)
    Abstract [en]

    An incentive for distribution companies to improve the efficiency of their operation is being suggested by Energimarknadsinspektionen.

    In terms of efficiency, 54 out of 159 network companies have higher distribution losses than 4% on an annual basis. If these 54 had made improvements in their power grids and reached an energy loss of 4%, this would mean a reduction of 143 GWh / year overall. Assuming a cost of 50 öre / kWh this would equivalent to 72 million kr / year. This may be unnecessary loss of having to pay at the connection point, but also a missing income for the distribution network owner.

    Surveys from electricity companies show what future challenges are ranging from increased energy metering requirements and reinforcements. The questionnaire shows that there is a large spread of how network companies manage their network losses, how to handle non-technical losses (ITF) and how they go about to locate and identify them. Compared to the cost of the new generation meters, storage costs for additional metrics and increased measurement resolution will not be the major cost driver.

    In this report, correlation, power flow analysis and machine learning are evaluated in order to detect and locate different types of ITF. With the help of machine learning, losses can be located without perfect knowledge of the power grid structure as long as these losses follow the usage pattern, and periods without ITF are available for the learning of the machine learning algorithm. For random losses, 3 different methods have been evaluated (SiM, K: SE and K: V) that show promising results with regard to localizing and detecting ITF using voltage values of energy meters. The resolution of the energy meters and its influence on the possibility to localize a ITF has also been studied.

  • Hjalmarsson-Jordanius, Anders
    et al.
    RISE - Research Institutes of Sweden, ICT, Viktoria. University of Borås, Sweden.
    Sundin, Niklas
    Consat Engineering, Sweden.
    Romell, Martin
    Volvo Car Group, Sweden.
    Isacson, Johan
    Combitech AB, Sweden.
    Aldén, Carl-Johan
    SEMCON Sweden AB, Sweden.
    Disrupting Automotive Logistics: Through a Combined Intelligent and Autonomous Transport Solution2017Conference paper (Refereed)
    Abstract [en]

    This technical paper addresses a novel and scalable autonomous transport system, applied in theautomotive logistics context. Production cars will be utilized as their own means of transportation in thelogistic chain, requiring no human driver. The cars will be guided by a novel intelligent transport solutioncombined with existing on-board Advanced Driver Assistance Systems (ADAS) functionality. Thisincludes using implemented sensors in the production car, fusion of sensor data collected by the car,and connectivity with existing and future mobile networks communication technology. An intelligent offboardtraffic control system will manage each production car in the logistic flow and direct the car frompoint A to point B, as well as manage the interaction between cars in the flow. A prototype of the systemhas been developed, implemented in a production car and during 2017, being tested in live car-trials inSweden. In this technical paper, we describe this evolution in vehicle logistics with a focus on its onboardcore sub-system and the off-board traffic control system. We pinpoint design features in thesystem, as well as discuss the capacity for the system to disrupt contemporary models of automotivelogistics.

  • Public defence: 2019-02-15 09:15 80101, Uppsala
    Banerjee, Amitava
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Materials Modelling for Energy Harvesting: From Conversion to Application through Storage2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In this Ph.D. thesis, ab initio density functional theory along with molecular dynamics and global optimization methods are used to unveil and understand the structures and properties of energy relevant materials. In this connection, the following applications are considered: i. electrocatalyst for solar fuel production through water splitting, ii. hybrid perovskite solar cell for generation of electrical energy and iii. Battery materials to store the electrical energy. The water splitting mechanism in terms of hydrogen evolution and oxygen evolution reactions (HER and OER) on the catalytic surfaces has been envisaged based on the free energy diagram, named reaction coordinate, of the reaction intermediates. The Ti-functionalized two-dimensional (2D) borophene monolayer has been emerged as a promising material for HER and OER mechanisms as compared to the pristine borophene sheet. Further investigation in the series of this noble metal free monolayer catalyst is 2D Al2C monolayer both in form of pristine and functionalized with nitrogen (N), phosphorous (P), boron (B), and sulphur (S). It has been observed that only B substituted Al2C shows very close to thermoneutral, that could be the most promising candidate for HER on functionalized Al2C monolayer. The adsorption of O* intermediate is stronger in S-substituted Al2C, whereas it is less strongly adsorbed on N-substituted Al2C. The subsequent consideration is being the case of n-type doping (W) along with Ti codoped in BiVO4 to enhance the efficiency of BiVO4 photoanode for water splitting. The determined adsorption energy and corresponding Gibbs free energies depict that the Ti site is energetically more favorable for water splitting. Moreover, the Ti site possesses a lower overpotential in the W–Ti codoped sample as compared to the mono-W doped sample. We have also explored the effect of mixed cation and mixed anion substitution in the hybrid perovskite in terms of structural stability, electronic properties and optical response of hybrid perovskite crystal structures. It has been found that the insertion of bromine (Br) into the system could modulate the stability of the Guanidinium lead iodide (GAPbI3) hybrid perovskite.  Moreover, the band gap of the mixed hybrid perovskite is increased with the inclusion of smaller Br anion while replacing partially the larger iodine (I) anion. Finally the electrochemical storage mechanism for Sodium (Na) and lithium (Li) ion insertion has been envisaged in inorganic electrode (eldfellite, NaFe(SO4)2) as well as in more sustainable organic electrode (di-lithium terephthalate, Li2TP). The full desodiation capability of the eldfellite enhances the capacity while the activation energies (higher than 1 eV) for the Na+ ion diffusion for the charged state lower the ionic insertion rate. The key factor as the variation of Li-O coordination in the terephthalate, for the disproportionation redox reaction in Li2TP is also identified.

  • Tegenu, Tsegaye
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    National Industrial Policy by Design Thinking2019Report (Other academic)
    Abstract [en]

    This study attempts to discuss the theory and practice of national industrial policy based on the rationale and methods of design thinking. The study examines the core of design thinking in industrial policy, specify the procedures and tasks of designers in developing the policy process model, discusses the rationale and options of industrial policy design practices, argue for and lists the characteristics of best design thinking industrial policy for least developed countries. There is a paucity of empirical evidence on how design thinking based industrial policy contributes to industrial growth. It is hoped that the argument, concepts and methods presented in this paper may stimulate sophisticated discussion on the theory, tools and procedures of design thinking in industrial policy performance assessment and improvement.

    Design thinking is an alternative approach to solve problems of least developed countries which start industrialization from scratch under conditions of low level of input market and private sector development and rapid population growth effects. Spreading the awareness of design thinking skills and approach in national industrial policymaking and implementation helps to tackle the root causes of internal and international migration crisis.

  • van der Weerdt, Caroline
    et al.
    TNO Netherlands Organisation for Applied Scientific Research, The Netherlands.
    Hjalmarsson, Anders
    RISE - Research Institutes of Sweden, ICT, Viktoria.
    Bridging the gap between service providers and people2017Conference paper (Refereed)
  • van Amelsfort, Dirk
    et al.
    RISE - Research Institutes of Sweden, ICT, Viktoria.
    Hjalmarsson, Anders
    RISE - Research Institutes of Sweden, ICT, Viktoria. University of Borås, Sweden.
    Business Models for Incentive-based Mobility Services for Changing Traveller Behaviour2016Conference paper (Refereed)
    Abstract [en]

    This paper presents the development and application of a process and methodology to develop business models for sustainable mobility services that aim at changing travel behaviour and shifting people from carbon fuelled vehicles (CFVs) to other means of transportation. The mobility services will be implemented in 4 lead cities and 11 take up cities in Europe as part of the European project Empower. The paper summarises three deliverables within the project in which a literature study and case review, methodology development, and business model development in the 4 lead cities were conducted.

  • Arvidsson, Anna K
    et al.
    Swedish National Road and Transport Research Institute, Infrastructure, Infrastructure maintenance.
    Lundberg, Thomas
    Swedish National Road and Transport Research Institute, Infrastructure, Infrastructure maintenance.
    Kalman, Björn
    Swedish National Road and Transport Research Institute, Infrastructure, Pavement Technology.
    Ekström, Camilla
    Swedish National Road and Transport Research Institute, Traffic and road users, Traffic Safety and Traffic System.
    Cruz Del Aguila, Fernando
    Eriksson, Olle
    Swedish National Road and Transport Research Institute, Infrastructure, Infrastructure maintenance.
    Friktions- och texturutveckling på nya beläggningar2019Report (Other academic)
    Abstract [en]

    A new pavement should be and be perceived as safe by road users, regardless of the road condition. It is therefore important that the road has a satisfactory level of friction already when the road is opened. There is limited documented knowledge of how the road change in the beginning after a paving performance.

    The purpose of this project is to determine how friction changes during the first period after road pavement is laid and traffic is permitted. The ambition is to determine if new road sections have reduced friction and provide recommendations for when a friction measurement is to be performed, and how warning signs should be displayed in connection with the pavement work. The study plan has been to follow different objects with frequent friction and texture measurements from just before the stretch is opened for traffic until the levels have stabilised.

    Initially, friction is high, and then decreases with the amount of traffic. After 1-3 weeks the lowest value was reached and then the friction increased or stabilized. Common to all investigated stretches, there are major changes in texture levels from the first vehicle and then a decreasing textural level until a stable level is reached after 1-3 weeks.

  • Brüggemann, Jelmer
    et al.
    Linköping University, Department of Thematic Studies, Technology and Social Change. Linköping University, Faculty of Arts and Sciences.
    Forsberg, Camilla
    Linköping University, Department of Behavioural Sciences and Learning, Education, Teaching and Learning. Linköping University, Faculty of Educational Sciences.
    Thornberg, Robert
    Linköping University, Department of Behavioural Sciences and Learning, Education, Teaching and Learning. Linköping University, Faculty of Educational Sciences.
    Re-negotiating agency – patients using comics to reflect upon acting in situations of abuse in health care2019In: BMC Health Services Research, ISSN 1472-6963, E-ISSN 1472-6963, Vol. 19, no 1, article id 58Article in journal (Refereed)
    Abstract [en]

    Background

    There is a growing body of international research that displays the prevalence and character of abuse in health care. Even though most of these studies are conducted from a patient perspective little is known about how patients conceptualize their agency in relation to such situations. This study aimed to explore how patients reason about their potential to act in abusive situations.

    Methods

    Qualitative interviews were conducted with thirteen patients in Sweden. Central in the interviews were three comics, inspired by Boal’s Forum Theatre and part of an earlier online intervention study in which the informants had participated. Each comic showed a situation in which a patient feels abused, and on the opposite side were suggestions for how the patient could act in response. Informants were asked to reflect about situations of abuse and in specific upon the comics. We used the methodology of constructivist grounded theory throughout the study, including the analysis.

    Results

    It appeared that the informants constantly re-negotiated their and other patients’ agency in relation to the specifics of the event, patients’ and staff’s responsibilities, and the patients’ needs and values. This process questions views of agency as fixed and self-evident, and can be understood as part of changing discourses about patients’ social role and possibilities to organize their care. Using a feminist theory of power we expected the informants to elicit instances of resistance to domination, which is central to the comics. While doing that, the informants also hinted at parallel stories of empowerment and less visible forms of agency in spite of domination.

    Conclusion

    The current analysis showed different ways in which the informants constantly re-negotiated their agency in potentially abusive situations. Not only did the informants engage in reflections about immediate responses to these untoward situations, they also engaged in thoughts about strategies that could protect them and counteract abuse in health care over the long-term. This opens up for future research into ways patients organize their care and identify threats and barriers to the care they need, which could be valuable knowledge for care quality improvement.

  • Jansson, Sam Owen
    The Nordic Museum.
    Georg Stiernhielm och de kubiska målkärlen1950In: Fataburen: Nordiska museets och Skansens årsbok, Stockholm: Nordiska museets förlag, 1950, p. 109-118Chapter in book (Other academic)
  • Öhrlund, Isak
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Schultzberg, Mårten
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
    Bartusch, Cajsa
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Identifying and estimating the effects of a mandatory billing demand charge2019In: Applied Energy, ISSN 0306-2619, E-ISSN 1872-9118, Vol. 237, p. 885-895Article in journal (Refereed)
    Abstract [en]

    As peak demand for electricity continues to rise, distributors have begun charging small and medium-sized users for their short term demand rather than just their energy use. This is not only to meet the political aspirations for increased demand-side flexibility that now exist in many corners of the world, but to make sure that users are charged for the costs they incur. As it is only until recently that this type of users have come to face demand charges, there are however very few studies on what the actual effects of such pricing policies are, and those studies that do exist suffer from different methodological shortcomings that reduce their validity as a basis for real-world policy evaluations. This study provides the first state-of-the-art causal analysis of the demand response effects of a billing demand charge involuntarily introduced to small and medium sized users (35–63 A), using novel two-level time series models on retrospective observational consumption and survey data. Our analyses suggest that the tariff has induced an average response of −0.32 kWh/day per user over a two year long posttreatment period in comparison to a matched control group, equal to 7.4% of their daily average use during the pretreatment period. The response seems to have increased over time and to be greater during wintertime: around −0.70 kWh/day or 16.2% of the treated users’ average daily use during the pretreatment period. Comparing the individual users’ response to the size of their financial incentive to respond given the new tariff as well as their self-reported perception of the relative importance of electricity expenditures, we did not find any support for the common assumption that users with a higher financial incentive to respond do so to a greater extent. This might suggest that small and medium-sized commercial users, just as residential users, may exhibit non-financial drivers and barriers for engaging in demand response that may be vital to understand as policy makers and industry continue to seek increased demand-side flexibility.

  • Schoultz, Gösta, von
    The Nordic Museum.
    Till finrummets historia1950In: Fataburen: Nordiska museets och Skansens historia, Stockholm: Nordiska museets förlag, 1950, p. 91-108Chapter in book (Other academic)
  • Public defence: 2019-02-22 10:15 Häggsalen, Ångströmlaboratoriet, Uppsala
    Pavliuk, Mariia
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Accumulative Charge Separation in Photocatalysis: From Molecules to Nanoparticles2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Photochemical energy conversion into solar fuel involves steps of light absorption, charge separation and catalysis. Nature has taught us that the effective accumulation of redox equivalents and charge separation are the key steps in sunlight conversion. The focus of this thesis is to unveil photophysical and photochemical processes that lead to accumulative charge separation. The optimization of electron transfer process will be held by minimization of losses via recombination, and extension of the lifetime of the charge separated state by usage of the electron relay.

    The goal is to couple light induced electron transfer process with the multi-electron catalytic process of hydrogen evolution. In this regard, light harvesters (molecules, metal nanostructures) that generate at least two electrons per absorbed photon will be studied. Additionally, semiconductors that generate long-lived charge separated states are utilized to accumulate several redox equivalents necessary for hydrogen evolution.

    The hybrid systems produced by the combination of the advantageous properties of molecules, semiconductors, and metal nanoparticles are under the scope of investigation. Metal nanoparticles are advantageous because of their high absorption cross-section. The molecular linkers provide control and flexibility in tuning the connection between the light absorber and the electron relay. Semiconductor nanoparticles offer the desired charge separation properties via prolonging the lifetime sufficiently to perform photocatalysis.

    The detailed understanding, investigation and development of the hybrid systems is at the heart of the progress of photochemical solar fuel production.

  • Abramenkovs, Andris
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Stenerlöw, Bo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Removal of heat-sensitive clustered damaged DNA sites is independent of double-strand break repair2018In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 12, article id e0209594Article in journal (Refereed)
    Abstract [en]

    DNA double-strand breaks (DSBs) are the most deleterious lesions that can arise in cells after ionizing radiation or radiometric drug treatment. In addition to prompt DSBs, DSBs may also be produced during repair, evolving from a clustered DNA damaged site, which is composed of two or more distinct lesions that are located within two helical turns. A specific type of cluster damage is the heat-sensitive clustered site (HSCS), which transforms into DSBs upon treatment at elevated temperatures. The actual lesions or mechanisms that mediate the HSCS transformation into DSBs are unknown. However, there are two possibilities; either these lesions are transformed into DSBs due to DNA lesion instability, e.g., transfer of HSCS into single-strand breaks (SSBs), or they are formed due to local DNA structure instability, e.g., DNA melting, where two SSBs on opposite strands meet and transform into a DSB. The importance of these processes in living cells is not understood, but they significantly affect estimates of DSB repair capacity. In this study, we show that HSCS removal in human cells is not affected by defects in DSB repair or inhibition of DSB repair. Under conditions where rejoining of prompt DSBs was almost completely inhibited, heat-sensitive DSBs were successfully rejoined, without resulting in increased DSB levels, indicating that HSCS do not transfer into DSB in cells under physiological conditions. Furthermore, analysis by atomic force microscopy suggests that prolonged heating of chromosomal DNA can induce structural changes that facilitate transformation of HSCS into DSB. In conclusion, the HSCS do not generate additional DSBs at physiological temperatures in human cells, and the repair of HSCS is independent of DSB repair.

  • Lidén, Tomas
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    STAPLA-F research report. Version 32019Report (Other academic)
    Abstract [en]

    This research report documents the findings from the pre-study project STAPLA-F, conducted by Linköping University and Trafikverket via the research program KAJT. The purpose has been to investigate how strategic facility planning for balancing of maintenance and train traffic could be done, especially regarding switches and crossings (S&C). The project has also investigated the potentials for network simplifications and the removal of (redundant) S&C. Specifically, the station Katrineholm have been used as a case study.

    The results show that the economic potential for reducing the S&C maintenance spending can be in the range of 10% for midsize and larger stations, which translates to 70-80 MSEK per year, and that net traffic delays can be reduced by removal of redundant S&C. Furthermore, this is an interesting research problem, which has not yet been addressed in the research literature. Hence, it is recommended to continue with a PhD research project.

  • Went, Molly
    et al.
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Sud, Amit
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Speedy, Helen
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Sunter, Nicola J.
    Newcastle Univ, Northern Inst Canc Res, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
    Foersti, Asta
    German Canc Res Ctr, D-69120 Heidelberg, Germany;Lund Univ, Ctr Primary Hlth Care Res, SE-20502 Malmo, Sweden.
    Law, Philip J.
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Johnson, David C.
    Inst Canc Res, Div Mol Pathol, London SW7 3RP, England.
    Mirabella, Fabio
    Inst Canc Res, Div Mol Pathol, London SW7 3RP, England.
    Holroyd, Amy
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Li, Ni
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Orlando, Giulia
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Weinhold, Niels
    Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.
    van Duin, Mark
    Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands.
    Chen, Bowang
    German Canc Res Ctr, D-69120 Heidelberg, Germany.
    Mitchell, Jonathan S.
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Mansouri, Larry
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Juliusson, Gunnar
    Lund Univ, Lund Strateg Res Ctr Stem Cell Biol & Cell Therap, Hematol & Transplantat, Lund, Sweden.
    Smedby, Karin E.
    Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden.
    Jayne, Sandrine
    Univ Leicester, Ernest & Helen Scott Haematol Res Inst, Leicester, Leics, England.
    Majid, Aneela
    Univ Leicester, Ernest & Helen Scott Haematol Res Inst, Leicester, Leics, England.
    Dearden, Claire
    Inst Canc Res, Div Mol Pathol, London SW7 3RP, England.
    Allsup, David J.
    Hull Royal Infirm, Dept Haematol, Kingston Upon Hull, N Humberside, England.
    Bailey, James R.
    Hull York Med Sch, Kingston Upon Hull, N Humberside, England;Univ Hull, Kingston Upon Hull, N Humberside, England.
    Pratt, Guy
    Birmingham Heartlands Hosp, Dept Haematol, Birmingham, W Midlands, England.
    Pepper, Chris
    Cardiff Univ, Sch Med, Dept Haematol, Cardiff, S Glam, Wales.
    Fegan, Chris
    Cardiff & Vale Natl Hlth Serv Trust, Heath Pk, Cardiff, S Glam, Wales.
    Rosenquist, Richard
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Kuiper, Rowan
    Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands.
    Stephens, Owen W.
    Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.
    Bertsch, Uta
    German Canc Res Ctr, D-69120 Heidelberg, Germany;Natl Ctr Tumor Dis, D-69120 Heidelberg, Germany.
    Broderick, Peter
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Einsele, Hermann
    Univ Clin Wurzburg, D-97080 Wurzburg, Germany.
    Gregory, Walter M.
    Univ Leeds, Clin Trials Res Unit, Leeds LS2 9PH, W Yorkshire, England.
    Hillengass, Jens
    Heidelberg Univ, Dept Internal Med 5, D-69117 Heidelberg, Germany.
    Hoffmann, Per
    Univ Bonn, Inst Human Genet, D-53127 D- Bonn, Germany;Univ Basel, Dept Biomed, Div Med Genet, CH-4003 Basel, Switzerland.
    Jackson, Graham H.
    Royal Victoria Infirm, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.
    Joeckel, Karl-Heinz
    Univ Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany.
    Nickel, Jolanta
    Heidelberg Univ, Dept Internal Med 5, D-69117 Heidelberg, Germany.
    Noethen, Markus M.
    Univ Bonn, Inst Human Genet, D-53127 D- Bonn, Germany;Univ Bonn, Life & Brain Ctr, Dept Genom, D-53127 Bonn, Germany.
    da Silva Filho, Miguel Inacio
    German Canc Res Ctr, D-69120 Heidelberg, Germany.
    Thomsen, Hauke
    German Canc Res Ctr, D-69120 Heidelberg, Germany.
    Walker, Brian A.
    Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.
    Broyl, Annemiek
    Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands.
    Davies, Faith E.
    Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.
    Hansson, Markus
    Lund Univ, Ctr Primary Hlth Care Res, SE-20502 Malmo, Sweden;Lund Univ, Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden.
    Goldschmidt, Hartmut
    Heidelberg Univ, Dept Internal Med 5, D-69117 Heidelberg, Germany;Natl Ctr Tumor Dis, D-69120 Heidelberg, Germany.
    Dyer, Martin J. S.
    Univ Leicester, Ernest & Helen Scott Haematol Res Inst, Leicester, Leics, England.
    Kaiser, Martin
    Inst Canc Res, Div Mol Pathol, London SW7 3RP, England.
    Sonneveld, Pieter
    Erasmus MC Canc Inst, Dept Hematol, NL-3075 EA Rotterdam, Netherlands.
    Morgan, Gareth J.
    Univ Arkansas Med Sci, Myeloma Inst Res & Therapy, Little Rock, AR 72205 USA.
    Hemminki, Kari
    German Canc Res Ctr, D-69120 Heidelberg, Germany;Lund Univ, Ctr Primary Hlth Care Res, SE-20502 Malmo, Sweden.
    Nilsson, Bjorn
    Lund Univ, Dept Lab Med, Hematol & Transfus Med, BMC B13, SE-22184 Lund, Sweden;Broad Inst, 7 Cambridge Ctr, Cambridge, MA 02142 USA.
    Catovsky, Daniel
    Inst Canc Res, Div Mol Pathol, London SW7 3RP, England.
    Allan, James M.
    Newcastle Univ, Northern Inst Canc Res, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
    Houlston, Richard S.
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England;Inst Canc Res, Div Mol Pathol, London SW7 3RP, England.
    Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology2018In: Blood Cancer Journal, ISSN 2044-5385, E-ISSN 2044-5385, Vol. 9, article id 1Article in journal (Refereed)
    Abstract [en]

    The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) genome-wide association study (GWAS) data sets, totalling 11,734 cases and 29,468 controls. A significant genetic correlation between these two B-cell malignancies was shown (R-g = 0.4, P = 0.0046). Furthermore, four of the 45 known CLL risk loci were shown to associate with MM risk and five of the 23 known MM risk loci associate with CLL risk. By integrating eQTL, Hi-C and ChlP-seq data, we show that these pleiotropic risk loci are enriched for B-cell regulatory elements and implicate B-cell developmental genes. These data identify shared biological pathways influencing the development of CLL and, MM and further our understanding of the aetiological basis of these B-cell malignancies.

  • Gustafsson, Ingrid
    Internrevisionen och det paradoxala oberoendet2019Report (Other academic)
    Abstract [sv]

    Begreppet ”oberoende” används allt mer frekvent i samband med olika former av granskning. Ofta menas då att granskaren är oberoende från den granskade, till exempel genom att de tillhör olika organisationer. Men vad händer när oberoendeidealet ska praktiseras inom en organisation? Med internrevision inom Polisen som utgångspunkt studerar Ingrid Gustafsson hur och vad som ska skiljas åt för att berättelsen om oberoende ska bli trovärdig. Det är alltså inte en värdering av oberoendet som står i fokus, utan arbetet för att skapa det.

    Med hjälp av begreppet ”gränsarbete” studerar hon hur oberoende granskning hanteras och skapas generellt och bidrar samtidigt, mer specifikt, till en större förståelse för internrevisionens praktik och villkor.

  • Veldman, Sarina
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
    Kim, Seol-Jong
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
    van Andel, Tinde R.
    Naturalis Biodivers Ctr, POB 9517, NL-2300 RA Leiden, Netherlands.
    Font, Maria Bello
    Univ Oslo, Nat Hist Museum, Postboks 1172, N-0318 Oslo, Norway.
    Bone, Ruth E.
    Royal Bot Gardens, Richmond TW9 3AB, Surrey, England.
    Bytebier, Benny
    Univ KwaZulu Natal, Sch Life Sci, Bews Herbarium, Pr Bag X01, ZA-3209 Scottsville, South Africa.
    Chuba, David
    Univ Zambia, Dept Biol Sci, Box 32379, Lusaka, Zambia.
    Gravendeel, Barbara
    Naturalis Biodivers Ctr, POB 9517, NL-2300 RA Leiden, Netherlands;Leiden Univ, Inst Biol Leiden, POB 9505, NL-2300 RA Leiden, Netherlands;Univ Appl Sci Leiden, Zernikedreef 11, NL-2333 CK Leiden, Netherlands.
    Martos, Florent
    Univ KwaZulu Natal, Sch Life Sci, Bews Herbarium, Pr Bag X01, ZA-3209 Scottsville, South Africa;Sorbonne Univ, Museum Natl Hist Nat, CNRS, Inst Systemat Evolut Biodiversite ISYEB,EPHE, CP50,45 Rue Buffon, F-75005 Paris, France.
    Mpatwa, Geophat
    Copperbelt Univ, Sch Nat Resources, POB 21692, Kitwe, Zambia.
    Ngugi, Grace
    Univ KwaZulu Natal, Sch Life Sci, Bews Herbarium, Pr Bag X01, ZA-3209 Scottsville, South Africa;Natl Museums Kenya, East African Herbarium, POB 40658-00100, Nairobi, Kenya.
    Vinya, Royd
    Copperbelt Univ, Sch Nat Resources, POB 21692, Kitwe, Zambia.
    Wightman, Nicholas
    Homegarden Landscape Consultants Ltd, P Bag 30C, Lusaka, Zambia.
    Yokoya, Kazutoma
    Royal Bot Gardens, Richmond TW9 3AB, Surrey, England.
    de Boer, Hugo J.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology. Naturalis Biodivers Ctr, POB 9517, NL-2300 RA Leiden, Netherlands.
    Trade in Zambian Edible Orchids-DNA Barcoding Reveals the Use of Unexpected Orchid Taxa for Chikanda2018In: Genes, ISSN 2073-4425, E-ISSN 2073-4425, Vol. 9, no 12, article id 595Article in journal (Refereed)
    Abstract [en]

    In Zambia, wild edible terrestrial orchids are used to produce a local delicacy called chikanda, which has become increasingly popular throughout the country. Commercialization puts orchid populations in Zambia and neighbouring countries at risk of overharvesting. Hitherto, no study has documented which orchid species are traded on local markets, as orchid tubers are difficult to identify morphologically. In this study, the core land-plant DNA barcoding markers rbcL and matK were used in combination with nrITS to determine which species were sold in Zambian markets. Eighty-two interviews were conducted to determine harvesting areas, as well as possible sustainability concerns. By using nrITS DNA barcoding, a total of 16 orchid species in six different genera could be identified. Both rbcL and matK proved suitable to identify the tubers up to the genus or family level. Disa robusta, Platycoryne crocea and Satyrium buchananii were identified most frequently and three previously undocumented species were encountered on the market. Few orchid species are currently listed on the global International Union for the Conservation of Nature (IUCN) Red List. Local orchid populations and endemic species could be at risk of overharvesting due to the intensive and indiscriminate harvesting of chikanda orchids, and we therefore encourage increased conservation assessment of terrestrial African orchids.

  • Public defence: 2019-02-15 09:15 Room B41, Uppsala
    Treyer, Andrea
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    Characterization of parameters influencing intracellular bioavailability and prediction of intracellular drug exposure2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis work investigates factors influencing intracellular drug disposition. An experimental method for measurement of intracellular bioavailability (Fic), was used throughout. Fic is defined as the ratio between the unbound drug concentration inside the cell and the compound concentration in the cell exterior.

    First, the impact of transporter proteins—such as the uptake transporter OATP-1B1 and the efflux transporter P-gp—on Fic was assessed in isolation in singly transfected, well-characterized cell models. The net impact of ADME proteins on Fic, including drug transporter proteins and metabolic enzymes, was assessed in primary human hepatocytes. The results indicated that the Fic measurement accurately reflected system-dependent functionality of these proteins.

    Second, the impact of cellular lipids on Fic was studied, in particular phospholipids (a major constituent of cellular membranes) and neutral lipids (in the form of neutral lipid droplets in adipocytes). Drug partitioning to phospholipids was found to be the major determinant of intracellular fraction of unbound drug (fu,cell), while neutral lipid droplets and cellular proteins played a relatively smaller role. Therefore, the importance of phospholipids, and their major four subspecies—phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI)—was investigated in a cell-free approach with purified phospholipids.

    Finally, Fic was applied in two ways to drug discovery settings. First, Fic successfully harmonized system-dependent CYP450 enzyme inhibition values (IC50) obtained in human hepatocytes and human liver microsomes. Fic measured in suspended human hepatocytes also reflected hepatic enrichment factors of CYP450 inhibitors used in physiologically-based pharmacokinetic modelling. Second, Fic was used as a complementary tool to study the effect of cell-penetrating peptides on intracellular disposition of targeted antisense oligonucleotide conjugates.

    Overall, the thesis contributes to the mechanistic understanding of Fic and demonstrates its use for drug compound profiling at an early stage in drug discovery settings.

  • Åstrand, Per-Olof
    Swedish School of Sport and Health Sciences, GIH. Department of Physiology, Kungliga Gymnastiska Centralinstitutet, Stockholm.
    Experimental studies of physical working capacity in relation to sex and age1952Doctoral thesis, monograph (Other academic)
  • Fellström, Bengt
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Renal Medicine.
    Holmdahl, J.
    Univ Gothenburg, Sahlgrenska Acad, Dept Nephrol, Gothenburg, Sweden.
    Sundvall, N.
    Sunderby Hosp, Unit Nephrol, Lulea, Sweden.
    Cockburn, E.
    Astellas Pharma, Kastrup, Denmark.
    Kilany, S.
    Astellas Pharma, Kastrup, Denmark.
    Wennberg, L.
    Karolinska Univ Hosp, Div Transplantat Surg, Huddinge, Sweden;Karolinska Univ Hosp, CLINTEC, Huddinge, Sweden;Karolinska Inst, Stockholm, Sweden.
    Adherence of Renal Transplant Recipients to Once-daily, Prolonged-Release and Twice-daily, Immediate-release Tacrolimus-based Regimens in a Real-life Setting in Sweden2018In: Transplantation Proceedings, ISSN 0041-1345, E-ISSN 1873-2623, Vol. 50, no 10, p. 3275-3282Article in journal (Refereed)
    Abstract [en]

    Background. In this study we investigated medication adherence of kidney transplant patients (KTPs) to an immediate-release tacrolimus (IR-T) regimen and, after conversion, to a prolonged-release tacrolimus (PR-T) regimen in routine clinical practice. Methods. This was a non-interventional, observational, multicenter Swedish study. We included adult KTPs with stable graft function, remaining on IR-T or converting from IR-T to PR-T. Data were collected at baseline, and months 3, 6, and 12 post-baseline. The primary endpoint was adherence using the Basel Assessment of Adherence to Immunosuppressive Medication Scale (BAASIS). Secondary assessments included tacrolimus dose and trough levels, clinical laboratory parameters (eg, estimated glomerular filtration rate), and adverse drug reactions (ADRs). Results. Overall, data from 233 KTPs were analyzed (PR-T, n = 175; IR-T, n = 58). Mean change in PR-T dose from baseline (4.8 mg/d) to month 12 was -0.2 mg/d, and for IR-T (4.2 mg/d) was-0.4 mg/d; tacrolimus trough levels remained similar. Overall adherence was similar between baseline and month 12 in both groups (PR-T: 54.4% vs 57.0%, respectively; IR-T: 65.5% vs 69.4%); timing adherence followed a similar pattern. The probability of taking adherence improved between baseline and month 12 (odds ratio, 1.97; P =.0092) in the PR-T group only. Mean BAASIS visual analog scale score at baseline was 94.3 11.1% (PR-T) and 95.3 7.6% (IR-T), and >95% at subsequent visits. Laboratory parameters remained stable. Eight (4.6%) patients receiving PR-T (none receiving IR-T) had ADRs considered probably/possibly treatment-related. Conclusion. Disparity existed between high, patient-perceived and low, actual adherence. Overall adherence to the immunosuppressive regimen (measured by BAASIS) did not improve significantly over 12 months in stable KTPs converting to PR-T or remaining on IR-T; renal function remained stable.

  • Rahm, Lina
    Linköping University, Department of Behavioural Sciences and Learning, Education and Adult Learning. Linköping University, Faculty of Educational Sciences.
    Educational imaginaries: a genealogy of the digital citizen2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis makes use of a genealogical approach to map out and explainhow and why computers and citizenship have become so closely connected.It examines the historical continuities and disruptions, and the role thatpopular education has played in this interrelation. Drawing on previousresearch in the overlap between Swedish popular education history andhistorical computer politics, this thesis adds knowledge about howimaginaries of popular education, operating as silver bullet solutions toproblems with computerization, have had important functions as governingtools for at least 70 years. That is, Swedish popular education has since the1950s been imagined as a central solution to problems with computerization,but also to realize the societal potentials associated with computers.

    Specifically, this thesis makes two contributions: 1) Empirically, the thesisunearths archived, and in many ways forgotten, discourses around thehistorical enactment of the digital citizen, and the role of popular education,questioning assumptions that are taken for granted in current times; 2)Theoretically, the thesis proposes a conceptual model of educationalimaginaries, and specifically introduces the notion (and method) of‘problematizations’ into these imaginaries.

  • Marshall, Matilda
    Umeå universitet, Institutionen för kultur- och medievetenskaper.
    Hållbarhet till middag: En etnologisk studie om hur miljövänligt ätande praktiseras i vardagslivet2016Doctoral thesis, monograph (Other academic)
    Abstract [en]

    Sustainability has become a conspicuous term in the public and political debate, as well as in the landscapes of consumption. This study focuses on how people understand and practice sustainability through food in their everyday life. The aim is to describe and analyse sustainability as a collection of meaning-making practices by studying households that in some sense actively aim for an environmentally friendly and sustainable food consumption. The ethnographic fieldwork, mainly interviews and participant observations, included fifteen households in a municipality in northern Sweden during 2012-15. The dissertation centres around reoccurring themes: organic food, local food, food as culture and materiality, morality and distinction. Through these themes it became evident that the participants related sustainable food practices to more than environmental issues. Socioeconomic relations within the locality and the global world, as well as cultural norms, traditions and values related to food, were important aspects of a perceived sustainable society. Although occasionally seeming inconsistent and contradictory in their meaning-making of and commitment to practices revolving around ideals of (ecological) sustainability, the participants balanced multiple sustainabilities simultaneously. Besides the ecological aspect, they also wished for sustainable localities, household economy, social relations and personal wellbeing.

    Influenced by social practice theory the study pays attention to the competences, meanings and materials a practice is dependent on. The participants developed individual repertoires, or practice bundles, of sustainable food related practices that were meaningful in their everyday life. The development and expansion of such a bundle could be understood as a form of acquiring and maintaining green capital; a symbolic capital based upon shared green values which unite the possessors and distinguish them from those lacking such values. Green capital is expressed through green distinction, that is, using taste to differentiate between holders and non-holders of the symbolic capital. The participants separated themselves from both the large majority who did not yet understand or practise sustainability, and from “fanatics” who they perceived took sustainability in an extreme and unsound manner. A balanced approach to sustainability was favoured as the participants to a great extent valued a lifestyle adjustable to the preconditions of the contemporary Swedish society, such as social norms. The study shows how sustainability is constantly renegotiated and filled with new cultural meaning.

  • Öberg, Lisa
    Mittuniversitetet, Avdelningen för naturvetenskap.
    Treeline dynamics in short and long term perspectives: observational and historical evidence from the southern Swedish Scandes2013Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Treelines in high-mountain regions are constrained by heat deficiency, although the working mechanisms are still not entirely understood. Observational and paleoecological studies on treeline performance may contribute to increased understanding of the treeline phenomenon in general. The present thesis addresses elevational shifts of alpine treelines in the Swedish Scandes. By various analytical tools, the studies embrace widely different temporal scales.

    The concept treeline refers to the elevation (m a.s.l.) at a specific site of the upper individual tree of a certain tree species, at least 2 m tall. All the principal tree species in the Scandes are concerned, i.e. mountain birch (Betula pubescens ssp. czerepanovii), Norway spruce (Picea abies) and Scots pine (Pinus sylvestris).

    Paper I deals with regional treeline dynamics at more than 100 sites over the past 100 years. Concurrent with temperature rise by c. 1.4 °C over the same period, maximum treeline advances of all species amount to about 200 m. Thus, under ideal conditions, treelines respond in close equilibrium with air temperature evolution. However, over most parts of the landscape, treeline upshifts have been much smaller than 200 m, which relates to the combined action of geomorphology, wind, snow distribution and soil depth. After 1975, the birch has lost its role as the most rapidly advancing tree species, being superseded by pine and spruce.

    Paper II is a short-term (2005/2007-2010/2011) study of mountain birch treeline performance along a regional maritimity-continentality gradient. Upshift by 3.0 yr-1 in the maritime part of the gradient contrasts to retreat by 0.4 m yr-1 in the continental part. In the latter area, earlier and more complete melting of late-lying snow patches has seemingly progressed to a state when soil drought sets back the vigour of existing birches and precludes sexual regeneration and upslope advance of the treeline. In the maritime area, extensive and deep snow packs still exist above the treeline and constrain its position, although some release is taking place in the current warm climate.

    Paper III explores treeline change by phenotypic transformation of old-established stunted and prostrate spruce individuals (krummholz) growing high above the treeline and is based on analyses of radiocarbon-dated megafossils, preserved in the soil underneath clonal groups of spruce. Living spruce clones, which in some cases may date back to the early Holocene (9500 cal. yr BP), suggests that spruce immigrated from “cryptic” ice age refugia much closer to Scandinavia than conventionally thought. As the krummholz form presupposes open and windy habitats, it is inferred that permanently open spots prevailed in the high-mountain landscape even during periods when treelines in general were much higher than today.

    Paper IV reports radiocarbon dates of wood samples, retrieved from newly exposed glacier forefields at three main sites, located high above the modern treelines and embracing the entire Swedish Scandes. It appears that pine colonized early emerging nunataks already during the Late Glacial. Around 9600-9500 cal. yr BP a first massive wave of tree establishment, birch and pine, took place in “empty” glacier cirques. Both species grew 400-600 m above their present day treeline position and accordingly, the summer temperatures may have been 3.5 °C warmer than present (uncorrected for land uplift). During the entire interval 9600 to 4400 cal. yr BP, birch prospered 100-150 m above the uppermost pines. In response to Neoglacial cooling, treelines of both birch and pine descended until their final disappearance from the record 4400 and 5900 cal. yr BP, respectively. Thereafter, these habitats experienced increased snow accumulation and glacier inception.

  • Public defence: 2019-02-15 13:15 Polhemsalen, Uppsala
    Tsougkas, Konstantinos
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics.
    Combinatorial and analytical problems for fractals and their graph approximations2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The recent field of analysis on fractals has been studied under a probabilistic and analytic point of view. In this present work, we will focus on the analytic part developed by Kigami. The fractals we will be studying are finitely ramified self-similar sets, with emphasis on the post-critically finite ones. A prototype of the theory is the Sierpinski gasket. We can approximate the finitely ramified self-similar sets via a sequence of approximating graphs which allows us to use notions from discrete mathematics such as the combinatorial and probabilistic graph Laplacian on finite graphs. Through that approach or via Dirichlet forms, we can define the Laplace operator on the continuous fractal object itself via either a weak definition or as a renormalized limit of the discrete graph Laplacians on the graphs.

    The aim of this present work is to study the graphs approximating the fractal and determine connections between the Laplace operator on the discrete graphs and the continuous object, the fractal itself.

    In paper I, we study the number of spanning trees on the sequence of graphs approximating a self-similar set admitting spectral decimation.

    In paper II, we study harmonic functions on p.c.f. self-similar sets. Unlike the standard Dirichlet problem and harmonic functions in Euclidean space, harmonic functions on these sets may be locally constant without being constant in their entire domain. In that case we say that the fractal has a degenerate harmonic structure. We prove that for a family of variants of the Sierpinski gasket the harmonic structure is non-degenerate.

    In paper III, we investigate properties of the Kusuoka measure and the corresponding energy Laplacian on the Sierpinski gaskets of level k.

    In papers IV and V, we establish a connection between the discrete combinatorial graph Laplacian determinant and the regularized determinant of the fractal itself. We establish that for a certain class of p.c.f. fractals the logarithm of the regularized determinant appears as a constant in the logarithm of the discrete combinatorial Laplacian.

  • Öberg, Lisa
    et al.
    Mittuniversitetet, Institutionen för tillämpad naturvetenskap och design.
    Kullman, Leif
    Umeå University, Department of Ecology and Environmental Science, SE 90187 Umeå.
    Recent Glacier Recession – a New Source of Postglacial Treeline and Climate History in the Swedish Scandes2012In: Landscape Online, ISSN 1865-1542, E-ISSN 1865-1542, Vol. 26, p. 1-38Article in journal (Refereed)
    Abstract [en]

    Climate warming during the past century has imposed recession of glaciers and perennial snow/ice patches along the entire Swedish Scandes. On the newly exposed forefields, subfossil wood remnants are being outwashed from beneath ice and snow bodies. In Scandinavia, this kind of detrital wood is a previously unused source of postglacial vegetation and climate history. The present study reports radiocarbon dates of a set of 78 wood samples, retrieved from three main sites, high above modern treelines and stretching along the Swedish Scandes. In accord with previous studies, pine (Pinus sylvestris) colonized early emerging nunataks already during the Late Glacial. Around 9600-9500 cal. yr BP a first massive wave of tree establishment, birch and pine, took place in "empty" glacier cirques. Both species grew 400-600 m above their present-ay treeline position and the summer temperatures may have been 3.5 °C warmer than present. In respons to Neoglacial cooling, treelines of both birch and pine descended until their final disappearance from the record 4400 and 5900 cal. yr BP, respectively. During the entire interval 9600 to 4400 cal. yr BP, birch prospered in a 100-150 broad belt above the uppermost pines. The recent emergence of tree remnants in the current habitats relates to the contemporary episode of climate warming, possibly unprecedented for several past millennia. It is inferred, by an anology with the past, that in a future scenario with summers 3.5 ° warmer than present, the birch treeline may rise by 600 m or so.

  • Wällstedt, Niklas
    Stockholm University, Stockholm, Sweden.
    Managing Multiplicity: On Control, Care and the Individual2015Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This is a thesis about managing multiplicity. It analyses how people working in municipalities are managing, controlling, and caring for the complex and contradictory world they live in. Building on more than 100 interviews and observations, the thesis examines the multiple realities of those who work in public sector organisations. By studying (1) the work of managers on different organisational levels, controllers, professionals responsible for the care of others and, to a lesser extent, politicians; (2) the management control systems that are used in the work, and (3) the ongoing debates and legislations directed towards the management of care practices, the thesis makes an effort to analyse how the realities of these individuals; those active in controlling and caring, are constructed.

    The thesis makes several contributions to the literatures on management control and public management. Where earlier studies are either based on a functionalist conception of management control and public management (in which performance measures and control systems are tools in the hands of managers, that enable them to control other practices), or focused on understanding how control contributes to the construction of reality (making reality ontologically coherent, and therefore controllable), the present thesis argues that management can be approached and analysed as a practice devoted to managing ontological multiplicity, rather than as an activity devoted to control other practices or making reality controllable.

    By using the concept of ontological politics, the thesis shows that control often fails to make reality controllable, which makes the practice of management reliant on alternative ways to manage. The alternative to control that is analysed in the thesis is care, and the thesis argues that care could be seen as a way to manage, rather than as something that should be controlled: care is complementary to control when it comes to management. The thesis explicates how management by care is done in relation to management by control, and how they may become resources for each other in managing the complex and contradictory public sector.

  • Public defence: 2019-02-15 09:15 Sal VIII, Uppsala
    Nikoleris, Nikos
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Computer Systems.
    Efficient Memory Modeling During Simulation and Native Execution2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Application performance on computer processors depends on a number of complex architectural and microarchitectural design decisions. Consequently, computer architects rely on performance modeling to improve future processors without building prototypes. This thesis focuses on performance modeling and proposes methods that quantify the impact of the memory system on application performance.

    Detailed architectural simulation, a common approach to performance modeling, can be five orders of magnitude slower than execution on the actual processor. At this rate, simulating realistic workloads requires years of CPU time. Prior research uses sampling to speed up simulation. Using sampled simulation, only a number of small but representative portions of the workload are evaluated in detail. To fully exploit the speed potential of sampled simulation, the simulation method has to efficiently reconstruct the architectural and microarchitectural state prior to the simulation samples. Practical approaches to sampled simulation use either functional simulation at the expense of performance or checkpoints at the expense of flexibility. This thesis proposes three approaches that use statistical cache modeling to efficiently address the problem of cache warm up and speed up sampled simulation, without compromising flexibility. The statistical cache model uses sparse memory reuse information obtained with native techniques to model the performance of the cache. The proposed sampled simulation framework evaluates workloads 150 times faster than approaches that use functional simulation to warm up the cache.

    Other approaches to performance modeling use analytical models based on data obtained from execution on native hardware. These native techniques allow for better understanding of the performance bottlenecks on existing hardware. Efficient resource utilization in modern multicore processors is necessary to exploit their peak performance. This thesis proposes native methods that characterize shared resource utilization in modern multicores. These methods quantify the impact of cache sharing and off-chip memory sharing on overall application performance. Additionally, they can quantify scalability bottlenecks for data-parallel, symmetric workloads.

  • Säter Böe, Andreas
    et al.
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Sesseng, Christian
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Hox, Kristian
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    BRAVENT – Delrapport 2 ; Brannspredning i ventilasjonskanaler2019Report (Other academic)
    Abstract [en]

    This is sub-report 2 of the BRAVENT project (Fire and smoke distribution in ventilation ducts) which presents results from experiments where the risk of spreading fire and heat in ventilation ducts has been investigated. In the experiments, the effect of fire insulation on the duct, and mixing hot smoke with air at room temperature in the duct (as from adjacent rooms) has been investigated. The ventilation duct was connected to a furnace at one end and a fan at the other end. The furnace was heated to the desired temperature, and hot smoke was drawn through the duct at a certain velocity. Thermocouples measured the temperature both inside the duct (smoke gas temperatures) and on the duct’s external surface at different distances from the furnace.

  • Säter Böe, Andreas
    et al.
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Sesseng, Christian
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    Stensaas, Jan Paul
    RISE - Research Institutes of Sweden, Safety and Transport, Fire Research Norway.
    BRAVENT – Delrapport 1 : Teori- og kunnskapssammenstilling2019Report (Other academic)
    Abstract [en]

    Recently questions about whether spread of heat and smoke in ventilation ducts during a fire represent an increased risk for personal safety and loss of properties have been raised. The technical solutions currently used to fulfill the pre-accepted performance given in the guidelines to the building regulations with regard to fire protection of ventilation ducts are largely based on descriptions in SINTEF's Building Design Sheet 520.352 on fire- and smoke protection of ventilation systems, and in BV Netts Guide for fireproof ventilation, also known as the BVNett Guide. This topic was once again raised in connection with the revision of the 2017 edition of the building regulations, when it was pointed out in inquiry statements that the pre-accepted performances are insufficiently defined and that the solutions outlined in the Building Design Sheet and the BVNett Guide are not sufficiently documented.

    In order to elucidate this topic and provide scientific documentation on the extent to which the spread of heat and smoke in ventilation ducts represents a risk to persons and properties, the BRAVENT project (Fire and smoke spread in ventilation ducts) was initiated.

    The project investigates issues related to heat dissipation in ventilation ducts, clogging of filters in ventilation systems due to smoke, the effect of the seal-up strategy with respect to pressure build-up in the fire room and smoke spread through leakages in the construction.

    The objective of the sub-task presented in this report was to:

    Compile a theoretical basis for the experiments and analyzes to be carried out.

    1. Map relevant regulations for fire protection of ventilation systems.

    2. Map standards that are the basis for determining the fire resistance of components included in a ventilation system.

    3. Map the state-of-the-art regarding a. the need to fire insulate ventilation ducts.

    b. the need to install bypass channels to prevent the filter systems from being clogged by smoke particles.

    c. the effect of installing fire dampers in all fire-partitions with respect to smoke spread.

    d. how smoke can be spread via ventilation ducts and leaks in the building structure.

    e. the pros and cons of seal-up and extraction strategies.

    © RISE Research Institutes of Sweden

    This is sub-report 1, which summarizes the relevant, fire-related theory and state-of-the-art in the focus area. The report serves as the theoretical basis for planning of experiments and for the other activities in the BRAVENT project.

  • Uggla, Ylva
    et al.
    Örebro University, School of Humanities, Education and Social Sciences.
    Boström, Magnus
    Örebro University, School of Humanities, Education and Social Sciences.
    Ambivalence in environmental representation: A theoretical contribution2018In: Sociologisk forskning, ISSN 0038-0342, Vol. 55, no 4, p. 447-465Article in journal (Refereed)
    Abstract [en]

    In this paper, we examine the phenomenon of representation through the theoretical lens of ambivalence, concentrating on the people involved in representation: representatives. We argue that the theoretical concept of ambivalence can be helpful in analysing and understanding the various tensions environmental and other representatives encounter in their practice. Based on the concepts of “sociological ambivalence”, “ideological dilemma”, and “the organizational centaur”, as well as on insights from social studies of science and sustainability studies, the paper develops a typology of three potential sources of ambivalence: role conflicts, value conflicts, and conflicts between goals and means. In addition, the paper identifies various ways of coping with ambivalence, including the construction of meta-norms, organizational and network support, pragmatism, drawing boundaries for reasonable and acceptable actions, rule bending and discursive negotiation. The paper concludes that the concept of ambivalence adds crucial insights to the positions, practices, and challenges of environmental representatives and notes that ambivalence is not only a matter of tensions and conflicts but can be a source of reflexivity, learning, and agency.

  • Monteux, Sylvain
    Umeå universitet, Institutionen för ekologi, miljö och geovetenskap.
    A song of ice and mud: Interactions of microbes with roots, fauna and carbon in warming permafrost-affected soils2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Permafrost-affected soils store a large quantity of soil organic matter (SOM) – ca. half of worldwide soil carbon – and currently undergo rapid and severe warming due to climate change. Increased SOM decomposition by microorganisms and soil fauna due to climate change, poses the risk of a positive climate feedback through the release of greenhouse gases. Direct effects of climate change on SOM decomposition, through such mechanisms as deepening of the seasonally-thawing active layer and increasing soil temperatures, have gathered considerable scientific attention in the last two decades. Yet, indirect effects mediated by changes in plant, microbial, and fauna communities, remain poorly understood. Microbial communities, which may be affected by climate change-induced changes in vegetation composition or rooting patterns, and may in turn affect SOM decomposition, are the primary focus of the work described in this thesis.

    We used (I) a field-scale permafrost thaw experiment in a palsa peatland, (II) a laboratory incubation of Yedoma permafrost with inoculation by exotic microorganisms, (III) a microcosm experiment with five plant species grown either in Sphagnum peat or in newly-thawed permafrost peat, and (IV) a field-scale cold season warming experiment in cryoturbated tundra to address the indirect effects of climate change on microbial drivers of SOM decomposition. Community composition data for bacteria and fungi were obtained by amplicon sequencing and phospholipid fatty acid extraction, and for collembola by Tullgren extraction, alongside measurements of soil chemistry, CO2 emissions and root density.

    We showed that in situ thawing of a palsa peatland caused colonization of permafrost soil by overlying soil microbes. Further, we observed that functional limitations of permafrost microbial communities can hamper microbial metabolism in vitro. Relieving these functional limitations in vitro increased cumulative CO2 emissions by 32% over 161 days and introduced nitrification. In addition, we found that different plant species did not harbour different rhizosphere bacterial communities in Sphagnum peat topsoil, but did when grown in newly-thawed permafrost peat. Plant species may thus differ in how they affect functional limitations in thawing permafrost soil. Therefore, climate change-induced changes in vegetation composition might alter functioning in the newly-thawed, subsoil permafrost layer of northern peatlands, but less likely so in the topsoil. Finally, we observed that vegetation encroachment in barren cryoturbated soil, due to reduced cryogenic activity with higher temperatures, change both bacterial and collembola community composition, which may in turn affect soil functioning.

    This thesis shows that microbial community dynamics and plant-decomposer interactions play an important role in the functioning of warming permafrost-affected soils. More specifically, it demonstrates that the effects of climate change on plants can trickle down on microbial communities, in turn affecting SOM decomposition in thawing permafrost.

  • Sundström, Andreas
    et al.
    Stockholm University, Stocholm, Sweden.
    Wällstedt, Niklas
    Stockholm University, Stocholm, Sweden.
    Intresserande samverkan: Från samsyn till framsyn – en studie inom Trafikverket2017Report (Refereed)
    Abstract [sv]

    Denna rapport har som mål att studera hur Trafikverket praktiserar strategi tillsammans med andra intressenter och aktörer. Rapporten utgör delprojekt 3 i ett större treårigt projekt som genomförts inom Akademin för ekonomistyrning i staten (AES) vid Företagsekonomiska institutionen, Stockholms universitet. Projektet har finansierats av Trafikverket, inom ramen för FoI-portfölj nummer sex, Trafikverket – en modern myndighet. Tidigare delrapporter inom projektet har visat att det internt i organisationen finns flera bilder av hur strategin ska omsättas i praktiken, samt diskuterat vad som är viktigt i detta arbete. Då en stor del av Trafikverkets uppdrag genomförs av externa parter ingår det också i forskningsprojektet att studera vad som händer med Trafikverkets strategiska arbete i externa relationer. När flera organisationers strategier möts, påverkar och påverkas av varandra väcks frågor om hur strategier samverkar och hur sådan strategisk samverkan fungerar i praktiken. Målet med denna rapport är därför att utveckla kunskap om strategisk verksamhetsstyrning genom att koppla samman frågor om strategi med frågor om samverkan. Detta uppnås genom att studera hur samverkan fungerar i praktiken. Som grund för rapporten har tre olika exempel på praktiker studerats där Trafikverket möter andra aktörer i planering och genomförande av Trafikverkets arbete.

    För att utveckla förståelsen av samverkan antar studien ett samverkansperspektiv: studien tar utgångspunkt i praktiken, snarare än i de samverkande aktörerna. Till skillnad från tidigare samverkansstudiers fokus på enskilda organisationers nytta av att samverka, innebär detta samverkansperspektiv fördjupade frågor om hur olika aktörer med olika intressen verkar samman, och hur sådan samverkan fungerar i praktiken. För att kunna diskutera samverkan på ett konstruktivt sätt används tre teoretiska begrepp i rapporten: mångfald, intressering och löften. Med dessa begrepp som utgångspunkt inriktas analysen på att undersöka förutsättningar för samverkan. Utifrån analysen av samverkans förutsättningar presenteras i rapportens avslutande kapitel ett utvecklat förhållningssätt till samverkan: intresserande samverkan. 

  • Barnes, Christopher
    et al.
    AGH Univ Sci & Technol, Fac Geol Geophys & Environm Protect, Krakow, Poland.
    Majka, Jaroslaw
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Mineralogy Petrology and Tectonics. AGH Univ Sci & Technol, Fac Geol Geophys & Environm Protect, Krakow, Poland.
    Schneider, David
    Univ Ottawa, Dept Earth & Environm Sci, Ottawa, ON, Canada.
    Walczak, Katarzyna
    AGH Univ Sci & Technol, Fac Geol Geophys & Environm Protect, Krakow, Poland.
    Bukala, Michal
    AGH Univ Sci & Technol, Fac Geol Geophys & Environm Protect, Krakow, Poland.
    Kosminska, Karolina
    AGH Univ Sci & Technol, Fac Geol Geophys & Environm Protect, Krakow, Poland.
    Tokarski, Tomasz
    AGH Univ Sci & Technol, Acad Ctr Mat & Nanotechnol, Krakow, Poland.
    Karlsson, Andreas
    Swedish Museum Nat Hist, Dept Geosci, Stockholm, Sweden.
    High-spatial resolution dating of monazite and zircon revealsthe timing of subduction-exhumation of the Vaimok Lens in the Seve Nappe Complex (Scandinavian Caledonides)2019In: Contributions to Mineralogy and Petrology, ISSN 0010-7999, E-ISSN 1432-0967, Vol. 174, no 1, article id 5Article in journal (Refereed)
    Abstract [en]

    In-situ monazite Th-U-total Pb dating and zircon LA-ICP-MS depth-profiling was applied to metasedimentary rocks from the Vaimok Lens in the Seve Nappe Complex (SNC), Scandinavian Caledonides. Results of monazite Th-U-total Pb dating, coupled with major and trace element mapping of monazite, revealed 603 +/- 16 Ma Neoproterozoic cores surrounded by rims that formed at 498 +/- 10 Ma. Monazite rim formation was facilitated via dissolution-reprecipitation of Neoproterozoic monazite. The monazite rims record garnet growth as they are depleted in Y2O3 with respect to the Neoproterozoic cores. Rims are also characterized by relatively high SrO with respect to the cores. Results of the zircon depth-profiling revealed igneous zircon cores with crystallization ages typical for SNC metasediments. Multiple zircon grains also exhibit rims formed by dissolution-reprecipitation that are defined by enrichment of light rare earth elements, U, Th, P, +/- Y, and +/- Sr. Rims also have subdued Eu anomalies ( Eu/Eu* approximate to 0.6-1.2) with respect to the cores. The age of zircon rim formation was calculated from three metasedimentary rocks: 480 +/- 22 Ma; 475 +/- 26 Ma; and 479 +/- 38 Ma. These results show that both monazite and zircon experienced dissolution-reprecipitation under high-pressure conditions. Caledonian monazite formed coeval with garnet growth during subduction of the Vaimok Lens, whereas zircon rim formation coincided with monazite breakdown to apatite, allanite and clinozoisite during initial exhumation.

  • Karlsson, Magnus
    Lunds universitet.
    Minnesord: Johan Asplund som lärare2018In: Sociologisk forskning, ISSN 0038-0342, Vol. 55, no 4, p. 513-516Article in journal (Other academic)
  • Public defence: 2019-02-15 10:15 Häggsalen, Uppsala
    Mai, Juri
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Bridging McMurry and Wittig in One-Pot: Olefins from Stereoselective, Reductive Couplings of Two Aldehydes via Phosphaalkenes2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The formation of C=C bonds is of great importance for fundamental and industrial synthetic organic chemistry. There are many different methodologies for the construction of C=C bonds in the literature, but currently only the McMurry reaction allows the reductive coupling of two carbonyl compounds to form alkenes. This thesis contributes to the field of carbonyl olefinations and presents the development of a new synthetic protocol for a one-pot reductive coupling of two aldehydes to alkenes based on organophosphorus chemistry. The coupling reagent, a phosphanylphosphonate, reacts with an aldehyde to yield a phosphaalkene intermediate which upon activation with a base undergoes an olefination with a second aldehyde.

    A general overview of synthetic methods for carbonyl olefinations and the chemistry of phosphaalkenes is given in the background chapter. The Wittig reaction and its variations are discussed in detail. The synthesis, reactivity, properties and applications of phosphaalkenes are highlighted with particular focus on strategies to stabilize these otherwise reactive species.

    The third chapter describes a novel method for the reductive coupling of aldehydes. The activation of phosphaalkene intermediates by a hydroxide base, mechanistic studies, development of a one-pot procedure and investigations of the substrate scope are discussed. The new one-pot reaction is advantageous over the McMurry coupling since it allows the formation of unsymmetrical E-alkenes under mild conditions.

    The next chapter is dedicated to a modification of the reaction sequence. The results show that activation of the phosphaalkene with an alkoxide instead of hydroxide, followed by oxidation, generates a more reactive transient species that can undergo the coupling with electron rich (deactivated) aldehydes which was not possible under the initial reaction conditions.

    Chapter five describes a modification of the phosphanylphosphonate reagent that enables the preparation of alkenes with high Z-stereoselectivity.

    In the final chapter, chemical equilibria studies of triphenylphosphaalkenes are presented. It is found that phosphaalkenes with poor kinetic stabilization can also be used as intermediates in the carbonyl-to-alkene coupling chemistry.

    In summary, this thesis presents the development of an unprecedented synthetic method for the direct formation of C=C double bonds from two aldehydes together with strategies on improvements of the substrate scope and modifications to control the stereochemical outcome of the reaction.