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  • Aadland, Reidun C.
    et al.
    Norwegian University of Science and Technology (NTNU), Norway.
    Dziuba, Carter J.
    University of Calgary, Canada.
    Heggset, Ellinor B.
    RISE - Research Institutes of Sweden, Bioeconomy, PFI.
    Syverud, Kristin
    RISE - Research Institutes of Sweden, Bioeconomy, PFI.
    Torsæter, Ole
    Norwegian University of Science and Technology (NTNU), Norway.
    Holt, Thorleif
    SINTEF, Norway.
    Gates, Ian D.
    University of Calgary, Canada.
    Bryant, Steven L.
    University of Calgary, Canada.
    Identification of nanocellulose retention characteristics in porous media2018In: Nanomaterials, ISSN 2079-4991, Vol. 8, no 7, article id 547Article in journal (Refereed)
    Abstract [en]

    The application of nanotechnology to the petroleum industry has sparked recent interest in increasing oil recovery, while reducing environmental impact. Nanocellulose is an emerging nanoparticle that is derived from trees or waste stream from wood and fiber industries. Thus, it is taken from a renewable and sustainable source, and could therefore serve as a good alternative to current Enhanced Oil Recovery (EOR) technologies. However, before nanocellulose can be applied as an EOR technique, further understanding of its transport behavior and retention in porous media is required. The research documented in this paper examines retention mechanisms that occur during nanocellulose transport. In a series of experiments, nanocellulose particles dispersed in brine were injected into sandpacks and Berea sandstone cores. The resulting retention and permeability reduction were measured. The experimental parameters that were varied include sand grain size, nanocellulose type, salinity, and flow rate. Under low salinity conditions, the dominant retention mechanism was adsorption and when salinity was increased, the dominant retention mechanism shifted towards log-jamming. Retention and permeability reduction increased as grain size decreased, which results from increased straining of nanocellulose aggregates. In addition, each type of nanocellulose was found to have significantly different transport properties. Experiments with Berea sandstone cores indicate that some pore volume was inaccessible to the nanocellulose. As a general trend, the larger the size of aggregates in bulk solution, the greater the observed retention and permeability reduction. Salinity was found to be the most important parameter affecting transport. Increased salinity caused additional aggregation, which led to increased straining and filter cake formation. Higher flow rates were found to reduce retention and permeability reduction. Increased velocity was accompanied by an increase in shear, which is believed to promote breakdown of nanocellulose aggregates. © 2018 by the authors.

  • Public defence: 2018-08-17 10:00 B1014, Jönköping
    Rukundo, Johnson Bosco
    Jönköping University, Jönköping International Business School, JIBS, Economics.
    Employment, Competition and Firm Performance: A Sub-Saharan Africa Perspective2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis addresses employment, competition and firm performance with a focus on Sub-Saharan Africa. The thesis consists of three individual papers and an introductory chapter. The purpose of each paper is to analyze firm performance. The main region of interest is Sub-Saharan Africa where countries in this part of the world are at lower levels of economic development and have experienced economic transition and strong firm investments. The papers contribute to existing industrial organization research by studying the effects of competition on R&D, effects of firm performance on innovation, and the determinants of informal employment and monthly wage earnings.

    The first paper focuses on firm performance which is found to affect firm innovation positively. This suggests that a firm’s decision regarding the scope of its total sales impacts its innovation capabilities. The second paper investigates the relationship between competition, R&D expenditure and innovation. It is found that a firm’s research efforts increase with an increase in levels of competition but at a diminishing rate confirming a non-linear, inverted-U relationship between competition and research expenditures. The third paper analyzes what determines informal employment and monthly wage earnings in formal firms. The results show that marginal benefit of higher education is lower for informal employees and that returns on education are much higher for workers with higher education.

  • Rukundo, Johnson Bosco
    Jönköping University, Jönköping International Business School, JIBS, Economics. Department of Economics, College of Business and Economics, University of Rwanda, Kigali, Rwanda.
    Firm Performance And Innovation In The Developing Countries: Evidence From Firm-Level Survey2017In: Corporate Ownership & Control, ISSN 1727-9232, E-ISSN 1810-3057, Vol. 15, no 1, p. 235-245Article in journal (Refereed)
    Abstract [en]

    This paper investigates the relationship between firm performance and innovation in developing countries using micro data from enterprise surveys. The purpose is to empirically test the importance of firm performance in terms of sales, for a firm’s proneness to innovate specifically in developing countries. A two-stage least squares (2SLS) model is applied to a sample of 2356 firms from the manufacturing and service sectors. Results show that firm performance, defined as sales, is found to be a significant factor contributing to innovation among firms. This relationship holds in manufacturing firms even when distinguished from the services sector. The findings underline the importance of firms’ performance through increased sales. The paper adds to the existing limited research literature on performance and innovation studies in developing countries especially Africa. The paper results differ from previous research studies where focus has been on innovation impact towards performance. As a policy option, developing countries need to improve and promote an increase in firms’ sales that would spur them to introduce a new or substantially improved product or process.

  • Huang, Hongyun
    et al.
    Gen Hosp Armed Police Forces, Inst Neurorestoratol, Beijing 100039, Peoples R China..
    Young, Wise
    Rutgers State Univ, WM Keck Ctr Collaborat Neurosci, Piscataway, NJ USA..
    Chen, Lin
    Tsinghua Univ, Dept Neurosurg, Yuquan Hosp, Beijing, Peoples R China..
    Feng, Shiqing
    Tianjin Med Univ, Dept Orthopaed, Gen Hosp, Tianjin, Peoples R China..
    Al Zoubi, Ziad M.
    Al Saif Med Ctr, Jordan Ortho & Spinal Ctr, Amman, Jordan..
    Sharma, Hari Shanker
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Saberi, Hooshang
    Univ Tehran Med Sci, Dept Neurosurg, Brain & Spinal Injury Res Ctr, Tehran, Iran..
    Moviglia, Gustavo A.
    Maimonides Univ, Ctr Res & Engn Tissues & Cellular Therapy, Buenos Aires, DF, Argentina..
    He, Xijing
    Xi An Jiao Tong Univ, Dept Orthopaed, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China..
    Muresanu, Dafin F.
    Univ Med & Pharm, Dept Neurosci Iuliu Hatieganu, Cluj Napoca, Romania..
    Sharma, Alok
    LTMG Hosp, LTM Med Coll, Dept Neurosurg, Bombay, Maharashtra, India..
    Otom, Ali
    King Hussein Med Ctr RJRC Amman, Royal Rehabil Ctr, Amman, Jordan..
    Andrews, Russell J.
    NASA, Nanotechnol & Smart Syst, Ames Res Ctr, Silicon Valley, CA USA..
    Al-Zoubi, Adeeb
    Univ Illinois, Coll Med Peoria, Peoria, IL USA..
    Bryukhovetskiy, Andrey S.
    NeuroVita Clin Intervent & Restorat Neurol & Ther, Moscow, Russia..
    Chernykh, Elena R.
    Inst Fundamental & Clin Immunol, Lab Cellular Immunotherapy, Novosibirsk, Russia..
    Domanska-Janik, Krystyna
    Mossakowski Med Res Ctr, Stem Cell Bioengn Unit, Warsaw, Poland..
    Jafar, Emad
    Al Saif Med Ctr, Jordan Ortho & Spinal Ctr, Amman, Jordan..
    Johnson, W. Eustace
    Univ Chester, Fac Med Dent & Life Sci, Stem Cells & Regenerat Biol, Chester, Cheshire, England..
    Li, Ying
    UCL Inst Neurol, Dept Brain Repair & Rehabil, Spinal Repair Unit, London, England..
    Li, Daqing
    UCL Inst Neurol, Dept Brain Repair & Rehabil, Spinal Repair Unit, London, England..
    Luan, Zuo
    Navy Gen Hosp PLA, Dept Pediat, Beijing, Peoples R China..
    Mao, Gengsheng
    Gen Hosp Armed Police Forces, Inst Neurorestoratol, Beijing 100039, Peoples R China..
    Shetty, Ashok K.
    Texas A&M Hlth Sci Ctr, Coll Med, Inst Regenerat Med, Dept Mol & Cellular Med, College Stn, TX USA..
    Siniscalco, Dario
    Univ Campania Luigi Vanvitelli, Dept Expt Med, Naples, Italy..
    Skaper, Stephen
    Univ Padua, Dept Pharmaceut & Pharmacol Sci, Padua, Italy..
    Sun, Tiansheng
    PLA Army Gen Hosp, Dept Orthoped, Beijing, Peoples R China..
    Wang, Yunliang
    148th Hosp, Dept Neurol, Zibo, Shandong, Peoples R China..
    Wiklund, Lars
    Umea Univ, Dept Pharmacol & Clin Neurosci, Unit Neurol, Umea, Sweden..
    Xue, Qun
    Soochow Univ, Dept Neurol, Affiliated Hosp 1, Suzhou, Jiangsu, Peoples R China..
    You, Si-Wei
    Fourth Mil Med Univ, Xijing Hosp, Dept Ophthalmol, Xian, Shaanxi, Peoples R China..
    Zheng, Zuncheng
    Cent Hosp Taian, Dept Rehabil Med, Tai An, Shandong, Peoples R China..
    Dimitrijevic, Milan R.
    Baylor Coll Med, Houston, TX 77030 USA..
    El Masri, W. S.
    Robert Jones & Agnes Hunt Orthopaed Hosp, Spinal Injuries Unit, Oswestry, Shrops, England..
    Sanberg, Paul R.
    Univ S Florida, Morsani Coll Med, Ctr Excellence Aging Brain Repair, Tampa, FL USA..
    Xu, Qunyuan
    Capital Med Univ, Inst Neurosci, Beijing, Peoples R China..
    Luan, Guoming
    Capital Med Univ, Beijing Sanbo Brain Hosp, Dept Neurosurg, Beijing, Peoples R China..
    Chopp, Michael
    Henry Ford Hlth Syst, Henry Ford Hosp, Neurol Res, Detroit, MI USA..
    Cho, Kyoung-Suok
    Catholic Univ Korea, Uijongbu St Marys Hosp, Coll Med, Dept Neurosurg, Uijongbu, South Korea..
    Zhou, Xin-Fu
    Univ South Australia, Sansom Inst Hlth Res, Sch Pharm & Med Sci, Div Hlth Sci, Adelaide, SA, Australia..
    Wu, Ping
    Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA..
    Liu, Kai
    Hong Kong Univ Sci & Technol, Div Life Sci, Kowloon, Hong Kong, Peoples R China..
    Mobasheri, Hamid
    Univ Tehran, Inst Biochem & Biophys, Res Ctr, Tehran, Iran..
    Ohtori, Seiji
    Chiba Univ, Grad Sch Med, Dept Orthoped Surg, Chiba, Japan..
    Tanaka, Hiroyuki
    Osaka Univ, Grad Sch Med, Dept Orthopaed Surg, Osaka, Japan..
    Han, Fabin
    Liaocheng Univ, Ctr Stem Cells & Regenerat Med, Liaocheng Peoples Hosp, Liaocheng, Shandong, Peoples R China..
    Feng, Yaping
    Kunming Gen Hosp Chengdu Mil Command Chinese PLA, Dept Neurosurg, Kunming, Yunnan, Peoples R China..
    Zhang, Shaocheng
    Second Mil Med Univ, Changhai Hosp, Dept Orthoped, Shanghai, Peoples R China..
    Lu, Yingjie
    Chengde Dadu Hosp, Dept Neurosurg, Weichang, Hebei, Peoples R China..
    Zhang, Zhicheng
    PLA Army Gen Hosp, Dept Orthoped, Beijing, Peoples R China..
    Rao, Yaojian
    Luoyang Orthoped Hosp Henan Prov, Dept Neurosurg, Luoyang, Henan, Peoples R China..
    Tang, Zhouping
    Tongji Hosp, Tongji Med Coll HUST, Dept Neurol, Wuhan, Hubei, Peoples R China..
    Xi, Haitao
    Capital Med Univ, Dept Neurol, Beijing Rehabil Hosp, Beijing, Peoples R China..
    Wu, Liang
    Beijing Xiaotangshan Rehabil Hosp, Ctr Rehabil, Beijing, Peoples R China..
    Shen, Shunji
    Weihai Municipal Hosp, Dept Rehabil, Weihai, Shandong, Peoples R China..
    Xue, Mengzhou
    Zhengzhou Univ, Dept Neurorehabil, Affiliated Hosp 2, Zhengzhou, Henan, Peoples R China..
    Xiang, Guanghong
    Brain Hosp Hunan Prov, Changsha, Hunan, Peoples R China..
    Guo, Xiaoling
    PLA Army 266 Hosp, Dept Neurol, Chengde, Hebei, Peoples R China..
    Yang, Xiaofeng
    Zhejiang Univ, Dept Neurosurg, Coll Med, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China..
    Hao, Yujun
    Xinjiang Med Univ, Dept Neurosurg, Affiliated Hosp 1, Urumqi, Xinjiang, Peoples R China..
    Hu, Yong
    Univ Hong Kong, Dept Orthopaed & Traumatol, Pokfulam, Hong Kong, Peoples R China..
    Li, Jinfeng
    Umea Univ, Dept Pharmacol & Clin Neurosci, Unit Neurol, Umea, Sweden..
    Ao, Qiang
    China Med Univ, Dept Tissue Engn, Shenyang, Liaoning, Peoples R China..
    Wang, Bin
    Guangzhou Med Univ, Dept Traumatol, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China..
    Zhang, Zhiwen
    Chinese Peoples Liberat Army Gen Hosp, Dept Neurosurg, Affiliated Hosp 1, Beijing, Peoples R China..
    Lu, Ming
    Hunan Normal Univ, Dept Neurosurg, Affiliated Hosp 2, Hosp PLA 163, Changsha, Hunan, Peoples R China..
    Li, Tong
    Xinxiang Med Univ, Dept Neurol, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China..
    Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)2018In: Cell Transplantation, ISSN 0963-6897, E-ISSN 1555-3892, Vol. 27, no 2, p. 310-324Article, review/survey (Refereed)
    Abstract [en]

    Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version "Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)". The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility.

  • Anders G. Nord, Anders G.
    et al.
    Tronner, Kate
    Malmberg, Mattias
    Pigmentanalys av bemålade brädor från Björsäters stavkyrka i Östergötland2017In: Fornvännen, ISSN 1404-9430, Vol. 112, no 4, p. 257-259Article in journal (Other academic)
  • Leonard, Dag
    et al.
    Svenungsson, Elisabet
    Dahlqvist, Johanna
    Alexsson, Andrei
    Ärlestig, Lisbeth
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.
    Taylor, Kimberly E.
    Sandling, Johanna K.
    Bengtsson, Christine
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.
    Frodlund, Martina
    Jonsen, Andreas
    Eketjäll, Susanna
    Jensen-Urstad, Kerstin
    Gunnarsson, Iva
    Sjöwall, Christopher
    Bengtsson, Anders A.
    Eloranta, Maija-Leena
    Syvänen, Ann-Christine
    Rantapää-Dahlqvist, Solbritt
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.
    Criswell, Lindsey A.
    Rönnblom, Lars
    Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis2018In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 77, no 7, p. 1063-1069Article in journal (Refereed)
    Abstract [en]

    Objectives Patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) have increased risk of cardiovascular disease (CVD). We investigated whether single nucleotide polymorphisms (SNPs) at autoimmunity risk loci were associated with CVD in SLE and RA.

    Methods Patients with SLE (n=1045) were genotyped using the 200K Immunochip SNP array (Illumina). The allele frequency was compared between patients with and without different manifestations of CVD. Results were replicated in a second SLE cohort (n=1043) and in an RA cohort (n=824). We analysed publicly available genetic data from general population, performed electrophoretic mobility shift assays and measured cytokine levels and occurrence of antiphospholipid antibodies (aPLs).

    Results We identified two new putative risk loci associated with increased risk for CVD in two SLE populations, which remained after adjustment for traditional CVD risk factors. An IL19 risk allele, rs17581834(T) was associated with stroke/myocardial infarction (MI) in SLE (OR 2.3 (1.5 to 3.4), P=8.5x10(-5)) and RA (OR 2.8 (1.4 to 5.6), P=3.8x10(-3)), meta-analysis (OR 2.5 (2.0 to 2.9), P=3.5x10(-7)), but not in population controls. The IL19 risk allele affected protein binding, and SLE patients with the risk allele had increased levels of plasma-IL10 (P=0.004) and aPL (P=0.01). An SRP54-AS1 risk allele, rs799454(G) was associated with stroke/transient ischaemic attack in SLE (OR 1.7 (1.3 to 2.2), P=2.5x10(-5)) but not in RA. The SRP54-AS1 risk allele is an expression quantitative trait locus for four genes.

    Conclusions The IL19 risk allele was associated with stroke/MI in SLE and RA, but not in the general population, indicating that shared immune pathways may be involved in the CVD pathogenesis in inflammatory rheumatic diseases.

  • Råhlander, Moa
    The Långön pouch is not made from lizard skin2017In: Fornvännen, ISSN 1404-9430, Vol. 112, no 4, p. 249-251Article in journal (Other academic)
  • Esmieu, Charlène
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Raleiras, Patricia
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Berggren, Gustav
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    From protein engineering to artificial enzymes - biological and biomimetic approaches towards sustainable hydrogen production2018In: SUSTAINABLE ENERGY & FUELS, ISSN 2398-4902, Vol. 2, no 4, p. 724-750Article, review/survey (Refereed)
    Abstract [en]

    Hydrogen gas is used extensively in industry today and is often put forward as a suitable energy carrier due its high energy density. Currently, the main source of molecular hydrogen is fossil fuels via steam reforming. Consequently, novel production methods are required to improve the sustainability of hydrogen gas for industrial processes, as well as paving the way for its implementation as a future solar fuel. Nature has already developed an elaborate hydrogen economy, where the production and consumption of hydrogen gas is catalysed by hydrogenase enzymes. In this review we summarize efforts on engineering and optimizing these enzymes for biological hydrogen gas production, with an emphasis on their inorganic cofactors. Moreover, we will describe how our understanding of these enzymes has been applied for the preparation of bio-inspired/-mimetic systems for efficient and sustainable hydrogen production.

  • Aktaş, Vezir
    et al.
    Jönköping University, School of Education and Communication, HLK, Lifelong learning/Encell.
    Nilsson, Marco
    Jönköping University, School of Education and Communication, HLK, Global Studies. Jönköping University, School of Education and Communication, HLK, Learning Practices inside and outside School (LPS), Plats, Identitet, Lärande (PIL).
    Borell, Klas
    Jönköping University, School of Health and Welfare, HHJ. SALVE (Social challenges, Actors, Living conditions, reseach VEnue).
    Social scientist under threat: Resistance and self-censorship in Turkish academia2018In: British Journal of Educational Studies, ISSN 0007-1005, E-ISSN 1467-8527Article in journal (Refereed)
    Abstract [en]

    Attacks on academic freedom in Turkey have become increasingly systematic in recent years and thousands of academics have been dismissed. This study reflects on the effects of this worsening repression through interviews with academics in the social sciences, both those dismissed and those still active in their profession. Although the dismissed academics are socially in a very precarious position, they are continuing their scholarly activities in alternative, underground forms. This resistance stands in contrast to the accommodation and self-censorship that seem, according to the interviewees, to prevail in university departments.

  • Regner, Elisabet
    Bön med band av stenar2017In: Fornvännen, ISSN 1404-9430, Vol. 112, no 4, p. 227-248Article in journal (Other academic)
  • Wadsten, Charlotta
    et al.
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Department of Surgery, Sundsvall Hospital, Sundsvall, Sweden.
    Wennstig, A.-K
    Garmo, H.
    Nilsson, Greger
    Blomqvist, Carl
    Holmberg, Lars
    Fredriksson, Irma
    Wärnberg, F.
    Sund, Malin
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
    Risk of ischemic heart disease after radiotherapy for ductal carcinoma in situ2018In: Breast Cancer Research and Treatment, ISSN 0167-6806, E-ISSN 1573-7217, Vol. 171, no 1, p. 95-101Article in journal (Refereed)
    Abstract [en]

    Purpose: The use of adjuvant radiotherapy (RT) in the management of ductal carcinoma in situ (DCIS) is increasing. Left-sided breast irradiation may involve exposure of the heart to ionising radiation, increasing the risk of ischemic heart disease (IHD). We examined the incidence of IHD in a population-based cohort of women with DCIS.

    Methods: The Breast Cancer DataBase Sweden (BCBase) cohort includes women registered with invasive and in situ breast cancers 1992-2012 and age-matched women without a history of breast cancer. In this analysis, 6270 women with DCIS and a comparison cohort of 31,257 women were included. Through linkage with population-based registers, data on comorbidity, socioeconomic status and incidence of IHD was obtained. Hazard ratios (HR) for IHD with 95% confidence intervals (CI) were analysed.

    Results: Median follow-up time was 8.8 years. The risk of IHD was not increased for women with DCIS versus women in the comparison cohort (HR 0.93; 95% CI 0.82-1.06), after treatment with radiotherapy versus surgery alone (HR 0.77; 95% CI 0.60-0.98) or when analysing RT by laterality (HR 0.85; 95% CI 0.53-1.37 for left-sided versus right-sided RT).

    Conclusions: The risk of IHD was lower for women with DCIS allocated to RT compared to non-irradiated women and to the comparison cohort, probably due to patient selection. Comparison of RT by laterality did not show any over-risk for irradiation of the left breast.

  • Nord, Anders G.
    et al.
    Tronner, Kate
    Billström, Kjell
    Asp, Misa
    Lundmark, Elin
    Björling Olausson, Karin
    Pigmentanalys av medeltida muralmålningar i sju norrlandskyrkor2017In: Fornvännen, ISSN 1404-9430, Vol. 112, no 4, p. 216-226Article in journal (Other academic)
  • Laine, Merit
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    Drømmebilleder. Carl Gustaf Pilos portrætkunst2018In: Konsthistorisk Tidskrift, ISSN 0023-3609, E-ISSN 1651-2294, Vol. 87, no 2, p. 115-118Article, book review (Other academic)
  • Ahola, Marja
    The material culture of Finnish Stone Age hunter-gatherer burials2017In: Fornvännen, ISSN 1404-9430, Vol. 112, no 4, p. 201-215Article in journal (Other academic)
  • Vladasel, Theodor
    Stockholm University, Faculty of Social Sciences, The Swedish Institute for Social Research (SOFI).
    Same, but different? Birth order, family size, and sibling sex composition effects in entrepreneurship2018Report (Other academic)
  • Hedman, Johannes
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Persson, Malin
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Samägd marktjänstutrustning på Stockholm Arlanda Airport2018Data set
    Abstract [sv]

    Flygindustrin har sett en stadig ökning de senaste åren och under 2017 ökade luftrumsrörelserna i Sverige med 6% från året innan. Den stadiga ökningen sätter stor press på det komplexa systemet som är på en flygplats då det är många parter som ska samarbeta. Därför krävs det att resurserna på flygplatsen utnyttjas optimalt för att få en flygplats som verkar effektivt. En av dessa parter som ofta hamnar i kläm är marktjänstbolagen, som både måste hålla låga priser för att flygbolagen ska kunna ha ett brett utbud till konkurrenskraftiga priser. Samtidigt som de måste betala de avgifter till flygplatsen som ökar i takt med trafiken.

    I nuläget tillhandahåller alla marktjänstbolag på Stockholm Arlanda Airport sin egen marktjänstutrustning, vilket gör att de måste optimera mängden utrustning efter sina egna toppar istället för hur helheten på flygplatsen ser ut. Något som leder till att det cirkulerar för mycket marktjänstutrustning på flygplatsen i nuläget. Därför undersöker detta examensarbetet om Stockholm Arlanda Airport kan få ett bättre resursutnyttjande med gemensam marktjänstutrustning och hur detta skulle påverka flygplatsens avgifter, samt vilka övriga effekter det kan medföra.

    Examensarbetet utgår från principen med förändringsarbete och modellen “Stegen i ett förbättringsarbete” används. Genom intervjuer med anställda på Swedavia och med information från marktjänstbolagen har nuläget kartlagts, vilket är det första steget i förbättringsarbetet. Författarna har även genom intervjuerna identifierat olika möjligheter och problem som kan uppstå med gemensam marktjänstutrustning. Mängden marktjänstutrustning som behövs med gemensam marktjänstutrustning beräknades genom intervallfärgning. Genom en totalkostnadsanalys har sedan tre olika förslag tagits fram på vilken typ av marktjänstutrustning som Swedavia borde äga för att det ska vara lönsamt för både Swedavia och marktjänstbolagen. De ekonomiska analyserna har tillsammans med de övriga effekterna legat till grund för de rekommendationer som författarna har givit till Swedavia.

    Författarna till rapporten har kommit fram till resultatet att med gemensam marktjänstutrustning finns ekonomiska besparingar att göraför både Swedavia och marktjänstbolagen. Andra effekter Stockholm Arlanda Airport kan vänta sig av förändringen är bland annat:

    Ökad flexibilitet

    • Genom att marktjänstbolagen kan använda all marktjänstutrustning
    • Genom att det alltid finns marktjänstutrustning på plats

    Mindre mängd marktjänstutrustning

    • Skapar fler fria ytor då det krävs mindre förvaringsytor

    Bättre arbetsmiljö

    • Då den ekonomiska pressen på marktjänstbolagen minskar

    Miljöpåverkan

    • Mindre utsläpp då Swedavia har större möjlighet att påverka vilken utrustning som används på flygplatsen
  • Psimopoulos, Emmanouil
    et al.
    Dalarna University, School of Technology and Business Studies, Energy Technology.
    Bee, E.
    Luthander, R.
    Bales, Chris
    Dalarna University, School of Technology and Business Studies, Energy Technology.
    Smart control strategy for PV and heat pump system utilizing thermal and electrical storage and forecast services2017Conference paper (Refereed)
  • Public defence: 2018-09-14 12:00 MA624, HuddingeGustafsson Gillbrand, Patrik
    Stenbruk: Stenartefakter, råmaterial och mobilitet i östra Mellansverige under tidig- och mellanmesolitikum2018Licentiate thesis, monograph (Other academic)
    Abstract [en]

    This thesis examines artefacts, raw materials and lithic technology between c. 9200–6200 cal BC in Eastern Central Sweden. The overall purpose of this study is to investigate when people first came to Eastern Central Sweden and where they came from. More precisely, it provides a typological, geo­graphical and chronological survey of artefacts and the use of different raw materials. The study deals with assemblages with artefacts from more than thirty archaeologically excavated sites and loose finds in Eastern Central Sweden. The objects consist of chubby pecked axes, core axes, flake axes, shaft hole picks, microliths and micro burins, points, burins, rulers, uni­facial blade core, conical cores, micro blade cores, blades, drills, re­touched blades and micro blades. The artefacts have been compared with established typologies and chronologies for the rest of the Nordic countries and to some extent Russia and the Baltic States. An analysis of different raw mater­ials present at Early and Middle Mesolithic sites in Eastern Central Sweden was also carried out. The materials are put into a chronological and geo­graphical context. The raw materials included in the study are the non-local rocks flint and Cambrian flint, as well as local raw materials such as quartz, greenstone, local vulcanite, mylonite and red porphyry. From 9200 cal BC there is evidence of the first groups of people in the area, just shortly after that the Weichselian ice cap had withdrawn. Throughout the period studied the artefacts as well as the non-local raw materials exhibit great similarities to those found in the western part of Sweden. The study also shows, regar­ding the use of different raw materials and presence of certain artefacts, that some major events took place, suggesting a new chronological time frame for the Early- and Middle Mesolithic periods. In addition, a discussion re­gar­­ding mobility and migration in Eastern Central Sweden during Early Post Glacial time is carried out.

  • Sotnikov, A.
    et al.
    Nielsen, C. K.
    Bales, Chris
    Dalarna University, School of Technology and Business Studies, Energy Technology.
    Dalenbäck, J. -O
    Andersen, Martin
    Dalarna University, School of Technology and Business Studies, Energy Technology.
    Psimopoulos, Emmanouil
    Dalarna University, School of Technology and Business Studies, Energy Technology.
    Simulations of a Solar-Assisted Block Heating System2017Conference paper (Refereed)
  • Bjurling, Björn
    et al.
    RISE - Research Institutes of Sweden, ICT, SICS.
    Aronsson, Martin
    RISE - Research Institutes of Sweden, ICT, SICS.
    DOIT WP4 Final Report on Planning and Optimization2018Report (Other academic)
  • Cenci, M. Angela
    et al.
    Jörntell, Henrik
    Petersson, Per
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). The Group for Integrative Neurophysiology and Neurotechnology, Neuronano Research Centre, Department Experimental Medical Science, Lund University, Lund, Sweden.
    On the neuronal circuitry mediating l-DOPA-induced dyskinesia2018In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 125, no 8, p. 1157-1169Article, review/survey (Refereed)
    Abstract [en]

    With the advent of rodent models of l-DOPA-induced dyskinesia (LID), a growing literature has linked molecular changes in the striatum to the development and expression of abnormal involuntary movements. Changes in information processing at the striatal level are assumed to impact on the activity of downstream basal ganglia nuclei, which in turn influence brain-wide networks, but very little is actually known about systems-level mechanisms of dyskinesia. As an aid to approach this topic, we here review the anatomical and physiological organisation of cortico-basal ganglia-thalamocortical circuits, and the changes affecting these circuits in animal models of parkinsonism and LID. We then review recent findings indicating that an abnormal cerebellar compensation plays a causal role in LID, and that structures outside of the classical motor circuits are implicated too. In summarizing the available data, we also propose hypotheses and identify important knowledge gaps worthy of further investigation. In addition to informing novel therapeutic approaches, the study of LID can provide new clues about the interplay between different brain circuits in the control of movement.

  • Pellegrini, Barbara
    et al.
    CeRiSM Res Ctr Mt Sport & Hlth, Rovereto, Italy; Univ Verona, Verona, Italy.
    Stoeggl, Thomas Leonhard
    Univ Salzburg, Salzburg, Austria.
    Holmberg, Hans-Christer
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences. UiT Arctic Univ Norway, Tromso, Norway.
    Developments in the Biomechanics and Equipment of Olympic Cross-Country Skiers2018In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 9, article id 976Article in journal (Refereed)
    Abstract [en]

    Here, our aim was to describe the major changes in cross-country (XC) skiing in recent decades, as well as potential future developments. XC skiing has been an Olympic event since the very first Winter Games in Chamonix, France, in 1924. Over the past decades, considerable developments in skiing techniques and improvements in equipment and track preparation have increased skiing speed. In contrast to the numerous investigations on the physiological determinants of successful performance, key biomechanical factors have been less explored. Today's XC skier must master a wide range of speeds, terrains, and race distances and formats (e.g., distance races with individual start, mass-start or pursuit; knock-out and team-sprint; relays), continuously adapting by alternating between various sub-techniques. Moreover, several of the new events in which skiers compete head-to-head favor technical and tactical flexibility and encourage high-speed techniques (including more rapid development of propulsive force and higher peak forces), as well as appropriate training. Moreover, the trends toward more extensive use of double poling and skiing without grip wax in classical races have given rise to regulations in connection with Olympic distances that appear to have preserved utilization of the traditional classical sub-techniques. In conclusion, although both XC equipment and biomechanics have developed significantly in recent decades, there is clearly room for further improvement. In this context as well, for analyzing performance and optimizing training, sensor technology has a potentially important role to play.

  • Kanaki, K.
    et al.
    European Spallation Source ESS ERIC, Lund.
    Klausz, M.
    European Spallation Source ESS ERIC, Lund; Hungarian Acad Sci, Budapest, Hungary; Budapest Univ Technol & Econ, Budapest, Hungary.
    Kittelmann, T.
    European Spallation Source ESS ERIC, Lund.
    Albani, G.
    Univ Milano Bicocca, Milan, Italy.
    Cippo, E. Perelli
    Assoc EURATOM ENEA CNR, Milan, Italy.
    Jackson, A.
    European Spallation Source ESS ERIC, Lund; Lund Univ, Lund.
    Jaksch, S.
    Forschungszentrum Julich, Heinz Maier Leibnitz Zentrum, Garching, Germany.
    Nielsen, T.
    European Spallation Source ERIC, Copenhagen, Denmark.
    Zagyvai, P.
    Hungarian Acad Sci, Budapest, Hungary; Budapest Univ Technol & Econ, Budapest, Hungary.
    Hall-Wilton, Richard
    Mid Sweden University, Faculty of Science, Technology and Media, Department of Electronics Design. European Spallation Source ESS ERIC, Lund.
    Detector rates for the Small Angle Neutron Scattering instruments at the European Spallation Source2018In: Journal of Instrumentation, ISSN 1748-0221, E-ISSN 1748-0221, Vol. 13, article id P07016Article in journal (Refereed)
    Abstract [en]

    Building the European Spallation Source (ESS), the most powerful neutron source in the world, requires significant technological advances at most fronts of instrument component design. Detectors are not an exception. The existing implementations at current neutron scattering facilities are at their performance limits and sometimes barely cover the scientific needs. At full operation the ESS will yield unprecedented neutron brilliance. This means that one of the most challenging aspects for the new detector designs is the increased rate capability and in particular the peak instantaneous rate capability, i.e. the number of neutrons hitting the detector per channel, pixel or cm(2) at the peak of the neutron pulse. This paper focuses on estimating the incident and detection rates that are anticipated for the Small Angle Neutron Scattering (SANS) instruments planned for ESS. Various approaches are applied and the results thereof are presented.

  • Nilsson, Madeleine
    et al.
    Åbo Akademi.
    Lindwall, Lillemor
    Karlstad Universitet.
    Nilsson, Jan
    Karlstad Universitet.
    From, Ingrid
    Dalarna University, School of Education, Health and Social Studies, Caring Science/Nursing.
    Patientens delaktighet i val av vårdgivare. En litteratur review2018In: Nordisk tidsskrift for helseforskning, ISSN 1504-3614, E-ISSN 1891-2982, Vol. 14 årgang, no 1Article in journal (Refereed)
    Abstract [en]

    The idea behind care choice is that healthcare providers would be more responsive to patients' health problems and needs and in doing so compete with increased quality and that patients should be able to choose from this. The question is how patients choose a healthcare provider by themselves. The aim was to describe what affected when patients chose healthcare providers. A literature review was carried out. The results showed that patients' choice of healthcare providers depended on the following three themes: their own care experiences, caring relationships with staff and service provided by caregivers. The underlying idea of care choice is competition based on quality of care, but the results show that patients make their choices based on other factors as described in the result and therefore improvement can be achieved if focus is placed on being responsive for patient care needs.

  • Ekblad, Laura L.
    et al.
    Johansson, Jarkko
    Umeå University, Faculty of Medicine, Department of Radiation Sciences. Turku PET Centre, University of Turku, Finland.
    Helin, Semi
    Viitanen, Matti
    Laine, Hanna
    Puukka, Pauli
    Jula, Antti
    Rinne, Juha O.
    Midlife insulin resistance, APOE genotype, and late-life brain amyloid accumulation2018In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 90, no 13, p. e1150-e1157Article in journal (Refereed)
    Abstract [en]

    Objective To examine whether midlife insulin resistance is an independent risk factor for brain amyloid accumulation in vivo after 15 years, and whether this risk is modulated by APOE epsilon 4 genotype. Methods This observational study examined 60 elderly volunteers without dementia (mean age at baseline 55.4 and at follow-up 70.9 years, 55.5% women) from the Finnish population-based, nationwide Health2000 study with [C-11]Pittsburgh compound B-PET imaging in 2014-2016. The participants were recruited according to their homeostatic model assessment of insulin resistance (HOMA-IR) values in the year 2000, and their APOE epsilon 4 genotype. The exposure group (IR+, n = 30) consisted of individuals with HOMA-IR > 2.17 at baseline (highest tertile of the Health2000 study population), and the control group (IR-, n = 30) consisted of individuals with HOMA-IR < 1.25 at baseline (lowest tertile). The groups were enriched for APOE epsilon 4 carriers, resulting in 50% (n = 15) APOE epsilon 4 carriers in both groups. Analyses were performed with multivariate logistic and linear regression. Results An amyloid-positive PET scan was found in 33.3% of the IR-group and 60.0% of the IR+ group (odds ratio 3.0, 95% confidence interval 1.1-8.9, p = 0.04). The increased risk was seen in carriers and noncarriers of APOE epsilon 4 genotype. Higher midlife, but not late-life continuous HOMA-IR was associated with a greater brain amyloid burden at follow-up after multivariate adjustments for other cognitive and metabolic risk factors (ss = 0.11, 95% confidence interval 0.002-0.22, p = 0.04). Conclusions These results indicate that midlife insulin resistance is an independent risk factor for brain amyloid accumulation in elderly individuals without dementia.

  • Public defence: 2018-08-31 13:00 Albertsalen, Trollhättan
    Islind, Anna Sigridur
    University West, School of Business, Economics and IT, Divison of Informatics.
    Platformization: Co-Designing Digital Platforms in Practice2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Digital platforms are slowly becoming an important part of both research and everyday work. However, much of the research focus has been on platforms that are already established. Little focus has been on platformization (i.e., design, development and use of platforms in the nascent phases) and the socio-technical aspects of designing platforms for specific practices or purposes, i.e., practicebased platforms. While it is truly important to understand technological aspects and market logics of platform efforts, it is also to understand how platforms become platforms, when designing them alongside end-users. This thesis contributes to the platform discussion with research that focuses both on the technological sides of building platforms while also unpacking the social aspectsof the collaborative design situation (i.e., co-design) and development where endusers meet and later use the platforms. This thesis explores the research questions:How can practice-based platforms be designed and developed? What impact does end-user engagement in platformization have on the practices involved? How can platformization efforts be approached and researched? through a study of the design of platforms in care settings, one 2.5–year study within home care and one 2.5–year study within cancer rehabilitation where the end-users' practices involved in the co-design processes are caregivers and care recipients in bothstudies. This thesis thereby unpacks the platformization process through a roughly five–year longitudinal AR project, based on these two studies. With thehelp of the boundary literature, the design, development and use of platforms inthe nascent phases of platformization is analysed in these two studies. Through aco-design effort in both studies, the practices that are going to use the platforms contribute to a) the design of which boundary resources (i.e., modules in terms of code blocks) will be developed within the platform; b) the design of the boundary object (i.e., working tools in terms of apps) that they are using together inconsensus; and c) the design of a boundary practice in which they will later use the digital artifacts together. The end-users' practices had impact on the design of all layers of the platform through the co-design approach, including an influence on the boundary resources that were developed within the platform. The platforms also had impact on the practices, which designed new ways of interacting. The results thereby both show the impact of the end-users' practices (caregivers and care recipients, which are heterogeneous) on the platform design, as well as the impact of the platform on the design of their boundary practice. In this thesis, the design and development of the two platforms is thereby researched and the design of the platforms is validated by studying the use of the platformsas well. The main contribution of this thesis is a conceptualization of the platformization process where the key characteristics of designing such platforms with heavy user engagement are illustrated in a platformization model and in seven platformization principles.

  • Bellini, Roseanna
    et al.
    Newcastle University, Sweden.
    Olivier, Patrick
    Newcastle University, Sweden.
    Comber, Rob
    RISE - Research Institutes of Sweden, ICT, SICS.
    "That really pushes my buttons": Designing bullying and harassment training for the Workplace2018In: Conference on Human Factors in Computing Systems - Proceedings, 2018Conference paper (Refereed)
    Abstract [en]

    Workplace bullying and harassment have been identified as two of the most concerning silent and unseen occupational hazards of the 21st century. The design of bespoke training addressing domain-specific job roles and relations presents a particular challenge. Using the concept of data-in-place where data is understood as being bound and produced by a particular place, this paper describes how locally-situated accounts can be used to engage employees in workplacespecific training seminars. Using higher education as a case study, we describe a four-stage design process for future training efforts: (1) in-depth interviews for further understanding of bullying and harassment; (2) design of digital probes for capturing contextual data; (3) probe deployment and subsequent data analysis; (4) data-driven discussion-based seminars. We outline the potential for digital probes in promoting the denormalization of toxic workplace cultures, considerations for novel sensitive data governance models, and the discussion of data-in-place's temporal dimension.

  • Brydsten, Anna
    et al.
    Stockholm Univ, Dept Publ Hlth Sci, SE-10691 Stockholm, Sweden.
    Hammarström, Anne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Public Health.
    San Sebastian, Miguel
    Umea Univ, Dept Publ Hlth & Clin Med, Epidemiol & Global Hlth Unit, SE-90185 Umea, Sweden.
    Health inequalities between employed and unemployed in northern Sweden: a decomposition analysis of social determinants for mental health2018In: International Journal for Equity in Health, ISSN 1475-9276, E-ISSN 1475-9276, Vol. 17, article id 59Article in journal (Refereed)
    Abstract [en]

    Background: Even though population health is strongly influenced by employment and working conditions, public health research has to a lesser extent explored the social determinants of health inequalities between people in different positions on the labour market, and whether these social determinants vary across the life course. This study analyses mental health inequalities between unemployed and employed in three age groups (youth, adulthood and mid-life), and identifies the extent to which social determinants explain the mental health gap between employed and unemployed in northern Sweden. Methods: The Health on Equal Terms survey of 2014 was used, with self-reported employment (unemployed or employed) as exposure and the General Health Questionnaire (GHQ-12) as mental health outcome. The social determinants of health inequalities were grouped into four dimensions: socioeconomic status, economic resources, social network and trust in institutional systems. The non-linear Oaxaca decomposition analysis was applied, stratified by gender and age groups. Results: Mental health inequality was found in all age groups among women and men (difference in GHQ varying between 0.12 and 0.20). The decomposition analysis showed that the social determinants included in the model accounted for 43-51% of the inequalities among youths, 42-98% of the inequalities among adults and 60-65% among middle-aged. The main contributing factors were shown to vary between age groups: cash margin (among youths and middle-aged men), financial strain (among adults and middle-aged women), income (among men in adulthood), along with trust in others (all age groups), practical support (young women) and social support (middle-aged men); stressing how the social determinants of health inequalities vary across the life course. Conclusions: The health gap between employed and unemployed was explained by the difference in access to economic and social resources, and to a smaller extent in the trust in the institutional systems. Findings from this study corroborate that much of the mental health inequality in the Swedish labour market is socially and politically produced and potentially avoidable. Greater attention from researchers, policy makers on unemployment and public health should be devoted to the social and economic deprivation of unemployment from a life course perspective to prevent mental health inequality.

  • Almström Persson, Gunilla
    Stockholm University, Faculty of Humanities, Department of Swedish Language and Multilingualism, Scandinavian Languages.
    "Kredd till dig för vår senaste tweet.": Kommunikativa val på Twitter under terrorattentatet på Drottninggatan2018In: Göteborgsstudier i nordisk språkvetenskap, Vol. 34, p. 79-95Article in journal (Other academic)
  • Kehoe, Kaat
    et al.
    Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Antwerp, Belgium.
    Noels, Heidi
    Rhein Westfal TH Aachen, Inst Mol Cardiovasc Res, Aachen, Germany.
    Theelen, Wendy
    Rhein Westfal TH Aachen, Inst Mol Cardiovasc Res, Aachen, Germany.
    De Hert, Emilie
    Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Antwerp, Belgium.
    Xu, Shenguan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Verrijken, An
    Antwerp Univ Hosp, Dept Endocrinol Diabetol & Metab, Edegem, Belgium;Univ Antwerp, Fac Med & Hlth Sci, LEMP, Antwerp, Belgium.
    Arnould, Thierry
    Univ Namur UNamur, Namur Res Inst Life Sci NARILIS, Lab Biochem & Cell Biol URBC, Namur, Belgium.
    Fransen, Erik
    Univ Antwerp, StatUa Ctr Stat, Antwerp, Belgium.
    Hermans, Nina
    Univ Antwerp, Dept Pharmaceut Sci, Nat Prod & Food Res & Anal Nat, Antwerp, Belgium.
    Lambeir, Anne-Marie
    Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Antwerp, Belgium.
    Venge, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Van Gaal, Luc
    Antwerp Univ Hosp, Dept Endocrinol Diabetol & Metab, Edegem, Belgium;Univ Antwerp, Fac Med & Hlth Sci, LEMP, Antwerp, Belgium.
    De Meester, Ingrid
    Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Antwerp, Belgium.
    Prolyl carboxypeptidase activity in the circulation and its correlation with body weight and adipose tissue in lean and obese subjects2018In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 5, article id e0197603Article in journal (Refereed)
    Abstract [en]

    Background Prolyl carboxypeptidase (PRCP) is involved in the regulation of body weight, likely by hydrolysing alpha-melanocyte-stimulating hormone and apelin in the hypothalamus and in the periphery. A link between PRCP protein concentrations in plasma and metabolic disorders has been reported. In this study, we investigated the distribution of circulating PRCP activity and assessed its relation with body weight and adipose tissue in obese patients and patients who significantly lost weight. Methods PRCP activity was measured using reversed-phase high-performance liquid chromatography in different isolated blood fractions and primary human cells to investigate the distribution of circulating PRCP. PRCP activity was measured in serum of individuals (n = 75) categorized based on their body mass index (BMI < 25.0; 25.0-29.9; 30.0-39.9; >= 40.0 kg/m(2)) and the diagnosis of metabolic syndrome. Differences in serum PRCP activity were determined before and six months after weight loss, either by diet (n = 45) or by bariatric surgery (n = 24). Potential correlations between serum PRCP activity and several metabolic and biochemical parameters were assessed. Additionally, plasma PRCP concentrations were quantified using a sensitive ELISA in the bariatric surgery group. Results White blood cells and plasma contributed the most to circulating PRCP activity. Serum PRCP activity in lean subjects was 0.83 +/- 0.04 U/L and increased significantly with a rising BMI (p<0.001) and decreased upon weight loss (diet, p<0.05; bariatric surgery, p<0.001). The serum PRCP activity alteration reflected body weight changes and was found to be positively correlated with several metabolic parameters, including: total, abdominal and visceral adipose tissue. Plasma PRCP concentration was found to be significantly correlated to serum PRCP activity (0.865; p<0.001). Additionally, a significant decrease (p<0.001) in plasma PRCP protein concentration (mean +/- SD) before (18.2 +/- 3.7 ng/mL) and 6 months after bariatric surgery (15.7 +/- 2.7 ng/mL) was found. Conclusion Our novel findings demonstrate that white blood cells and plasma contributed the most to circulating PRCP activity. Additionally, we have shown that there were significant correlations between serum PRCP activity and various metabolic parameters, and that plasma PRCP concentration was significantly correlated to serum PRCP activity. These novel findings on PRCP activity in serum support further investigation of its in vivo role and involvement in several metabolic diseases.

  • Almström Persson, Gunilla
    Stockholm University, Faculty of Humanities, Department of Swedish Language and Multilingualism, Scandinavian Languages.
    Det politiska reportaget: Om ögonvittnesskildring som persuasivt medel2018In: Text- och samtalsstudier från Södertörns högskola, ISSN 1386-291X, E-ISSN 1327-9556, Kritiska text- och diskursstudier, Vol. 6, p. 161-177Article in journal (Refereed)
    Abstract [en]

    This paper use rhetorical criticism methodology when investigating linguistic and rhetorical means in the reportage genre. The concept of eye-witness is explored in six reportage from the GDR-propaganda published in 1962. Through analysis of dialogue and perception in text, the notion of presence is discussed. An assumption is that presence in text can be of paramount importance for the technique of persuasion. It  is claimed that presence might be communicated though dialogues. However the main impact of presence is connected to the perceptivity of the narrator. Values and arguments are highly emphasized when detailed descriptions are experienced by the narrator. Consequently the con- clusion of the analysis is associated with the rhetorical concept evidentia. Finally it is claimed that the GDR-propaganda use reportage from industries and construction sites to show western countries the advan- tages of East German version of socialism. The concept of political myth is introduced and is in the final discussion connected to the myth of technical development and the myth of progress. The theoretical frame- work consists of rhetoric, linguistics, and literary studies.

  • Zalkalns, Lilita
    Stockholm University, Faculty of Humanities, Department of Slavic and Baltic Studies, Finnish, Dutch, and German, Baltic Languages.
    Uldis Ģērmanis un izdevniecība "Memento"2016In: Jaunā Gaita, ISSN 0448-9179, Vol. LXII, no 284, p. 53-55Article in journal (Other (popular science, discussion, etc.))
    Abstract [en]

    A summary of historian, publicist, and author Uldis Ģērmanis' collaboration with publishing house "Memento". "Memento" was established in Stockholm 1961, by leading exile Latvian socialdemocrats. Between 1986 and 1998 "Memento" published eleven books authored by Uldis Ģērmanis.

  • Pettersson, John H.-O.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway;Univ Sydney, Charles Perkins Ctr, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia;Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia;Natl Vet Inst, Dept Microbiol, Uppsala, Sweden.
    Bohlin, Jon
    Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
    Dupont-Rouzeyrol, Myrielle
    Inst Pasteur Nouvelle Caledonie, Unite Rech Expertise Dengue & Autres Arboviroses, Noumea, New Caledonia.
    Brynildsrud, Ola B.
    Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
    Alfsnes, Kristian
    Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
    Cao-Lormeau, Van-Mai
    Inst Louis Malarde, Unit Emerging Infect Dis, Tahiti, French Polynesi, France;Aix Marseille Univ, IHU Mediterranee Infect, VITROME, IRD,AP HM,SSA, Marseille, France.
    Gaunt, Michael W.
    London Sch Hyg & Trop Med, London, England.
    Falconar, Andrew K.
    Univ Norte, Dept Med, Barranquilla, Colombia.
    De Lamballerie, Xavier
    Aix Marseille Univ, UMR Unite Virus Emergents, IRD 190, IHU Mediterranee Infect,Inserm 1207, Marseille, France;Univ Mediterranee Infect, Inst Hosp, Publ Hosp Marseille, AP HM, Marseille, France.
    Eldholm, Vegard
    Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
    Musso, Didier
    Inst Louis Malarde, Unit Emerging Infect Dis, Tahiti, French Polynesi, France;Aix Marseille Univ, IHU Mediterranee Infect, VITROME, IRD,AP HM,SSA, Marseille, France.
    Gould, Ernest A.
    Aix Marseille Univ, UMR Unite Virus Emergents, IRD 190, IHU Mediterranee Infect,Inserm 1207, Marseille, France.
    Re-visiting the evolution, dispersal and epidemiology of Zika virus in Asia2018In: EMERGING MICROBES & INFECTIONS, ISSN 2222-1751, Vol. 7, article id 79Article in journal (Refereed)
    Abstract [en]

    Based on serological evidence and viral isolation, Zika virus (ZIKV) has circulated for many years relatively benignly in a sylvatic cycle in Africa and an urban cycle in South East Asia (SEA). With the recent availability of limited but novel Indian ZIKV sequences to add to the plethora of SEA sequences, we traced the phylogenetic history and spatio-temporal dispersal pattern of ZIKV in Asia prior to its explosive emergence in the Pacific region and the Americas. These analyses demonstrated that the introduction and dispersal of ZIKV on the Pacific islands were preceded by an extended period of relatively silent transmission in SEA, enabling the virus to expand geographically and evolve adaptively before its unanticipated introduction to immunologically naive populations on the Pacific islands and in the Americas. Our findings reveal new features of the evolution and dispersal of this intriguing virus and may benefit future disease control strategies.

  • Byass, Peter
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. MRC/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Education Campus, University of Witwatersrand, Parktown, South Africa.
    Jackson Cole, Catherine
    Davies, Justine I.
    Geldsetzer, Pascal
    Witham, Miles D.
    Wu, Yan
    Collaboration for impact in global health2018In: The Lancet Global Health, E-ISSN 2214-109X, Vol. 6, no 8, p. e836-e837Article in journal (Refereed)
  • Nordmark, Marie
    Dalarna University, School of Humanities and Media Studies, Swedish.
    Att skriva med och utan digitala redskap2018In: Skolverket, Läslyftet. Språk-, läs- och skrivutveckling Grundskola F-3. Modul: Tidig läs- och skrivundervisning. Del 7: Att skriva med och utan digitala redskap., Stockholm: Skolverket , 2018Chapter in book (Other academic)
    Abstract [sv]

    Del 7. Att skriva med och utan digitala verktyg

    Syftet med den här delen är att fördjupa förståelsen för skrivande med och utan digitala verktyg i skrivundervisningen.

    Lärare behöver vid planering och genomförande av undervisning såväl som vid bedömning göra didaktiska val utifrån vad det innebär för elevernas skrivutveckling att använda olika skrivverktyg. Utifrån detta diskuteras här olika val lärare ställs inför och vad de kan innebära. 

    I undervisningsaktiviteten får ni möjlighet att arbeta med ord och bild i samspel. Syftet är att ge eleverna möjlighet att reflektera över innehållet utifrån ett mottagarperspektiv.

  • Ranängen, Helena
    et al.
    Luleå University of Technology, Department of Business Administration, Technology and Social Sciences, Business Administration and Industrial Engineering.
    Cöster, Mathias
    Department of Business Studies, Uppsala University.
    Isaksson, Raine
    Department of Engineering Sciences, Quality Sciences, Uppsala Universit.
    Garvare, Rickard
    Luleå University of Technology, Department of Business Administration, Technology and Social Sciences, Business Administration and Industrial Engineering.
    From global goals and planetary boundaries to public governance: A framework for prioritizing organizational sustainability activities2018In: Sustainability, ISSN 2071-1050, E-ISSN 2071-1050, Vol. 10, no 8, article id 2741Article in journal (Refereed)
    Abstract [en]

    Background: A particular challenge in the work to realize the global goals for sustainable development is to find ways for organizations to identify and prioritize organizational activities that address these goals. There are also several sustainability initiatives, guidelines and tools to consider when planning, working with and reporting on sustainable development. Although progress has been made, little has been written about how organizations rise to and manage the challenge. The paper explores how organizations address sustainable development, which sustainability aspects they prioritize and whether previous research can improve the priority process by using materiality analysis approach. Methods: A case study approach was chosen. Data was collected by interactive workshops and documentation. The participating organizations were two Swedish municipalities; Results: The municipalities have introduced a number of sustainability aspects into their organizational governance, especially in terms of society, human rights and the environment. A materiality analysis was conducted to determine the relevance and significance of sustainability aspects. The result shows that climate action, biodiversity and freshwater use are aspects that should be prioritized; Conclusion: The materiality analysis methodology chosen for prioritizing of sustainability aspects was useful and easy to work with. However, the sustainability aspect matrix and the risk assessment have to be updated regularly in order to form an effective base for the materiality analysis.

  • Public defence: 2018-08-31 13:00 11D121, Karlstad
    Kjeang, Are
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Chemical Sciences (from 2013).
    Goda råd är inte dyra!: Om personlig energirådgivning i ett alltmer digitaliserat samhälle2018Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    Improving the efficiency of energy use across all the sectors – industrial, transport and households – is one of the many necessary approaches to be adopted to ensure sustainable development. The countries of the developing world have to play a key role in such a transition. In Sweden, for close to half a century now, the municipal energy-advising function has been a governmental instrument to support decision-makers in bringing about systemic changes to improve energy efficiency on the one hand and the share of renewable energy in the mix, on the other.  This licentiate thesis has its focus on this function over the said time-period. It has also documented and analysed the energy-advising function from a social perspective. The research shows that in an increasingly-digitalised society, energy-advising must be developed further to be able to reach and impact different categories of energy users – households, small and medium scale enterprises and organisations – more effectively. The Internet happens to be the first resort of most people seeking information on energy-related issues, these days. Digital services do offer a range of possibilities but cannot substitute for the much-needed personal contact, which is provided by the energy-advising function. In this thesis, focus groups, interviews and conversations with energy advisers, homeowners and experts have been availed of, and subsequently analysed. The results also show that personal energy advice is actually popular, indispensable and effective, where replacement of interior heating systems, refurbishment or new building constructions are concerned.

    This research also shows that interactions with energy advisers are useful to test and verify the suitability of ideas and solutions obtained from the Internet. Besides, the home in which these solutions may eventually be tried out, is the perfect place for having such conversations. In this context, the social skills of the energy adviser assume paramount importance. It has been noticed that the viewpoints and experiences of women in households have often been ignored.  Further, the focus on finding solutions has sometimes been narrowed down to the technical and economic aspects, while at other times, decisions have been based on environmental or social factors like maintenance of comfort levels. In order to make the energy advising function more effective and avail of what it has to offer for the journey towards greater sustainability, it needs to be given the importance it deserves by the municipalities and there is also a need of stronger interplay among the other governmental instruments.

  • Bauer, Barbara
    et al.
    Meier, Markus
    SMHI, Research Department, Oceanography.
    Casini, Michele
    Hoff, Ayoe
    Margonski, Piotr
    Orio, Alessandro
    Saraiva, Sofia
    SMHI, Research Department, Oceanography.
    Steenbeek, Jeroen
    Tomczak, Maciej T.
    Reducing eutrophication increases spatial extent of communities supporting commercial fisheries: a model case study2018In: ICES Journal of Marine Science, ISSN 1054-3139, E-ISSN 1095-9289, Vol. 75, no 4, p. 1306-1317Article in journal (Refereed)
  • Jose Perez-Palazon, Maria
    et al.
    Pimentel, Rafael
    SMHI, Research Department, Hydrology.
    Jose Polo, Maria
    Climate Trends Impact on the Snowfall Regime in Mediterranean Mountain Areas: Future Scenario Assessment in Sierra Nevada (Spain)2018In: Water, ISSN 2073-4441, E-ISSN 2073-4441, Vol. 10, no 6, article id 720Article in journal (Refereed)
  • Mukkavaara, Jani
    et al.
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Industrilized and sustainable construction.
    Jansson, Gustav
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Industrilized and sustainable construction.
    Olofsson, Thomas
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Industrilized and sustainable construction.
    Structuring information from BIM: A glance at bills of materials2018In: Proceedings of the 35th ISARC, Berlin, Germany, 2018, p. 362-368Conference paper (Refereed)
    Abstract [en]

    Industrialized house-builders are moving towards an enhanced production where management of information along the value chain is critical in order to deliver housing projects on time and with the desired quality. Today digital tools and systems are used in both design and production to produce, deliver and instruct actors throughout the phases of aproject. However, the information usually exists in different islands and manual transfers are required tokeep the flow of information between IT-systems and individuals continuous. A key to improving the ability for the members in different stages of a project to work with the same information is to facilitate different views. One of the building blocks for creating bridges between the islands of information is to introduce bills of materials which can be used to organize information for different purposes. Uniting the use of building information modeling (BIM) withbills of materials (BOM) is therefore our focus in this paper. This is done in the context of industrialized house-building and the facets which it brings to the subject. The aim of this paper is to present an early endeavor into a BOM based approach for structuring information from BIM models. A demonstration tool was developed, and together with application in a case project from an industrialized house-builder, the generation of BOMs from BIM data is illustrated and discussed. The findings illustrates that we can apply different structures to the information located in our BIM models and that we can produce a BOM perspective on our products. Also, it is highlighted that we still need further studies to better understand how application of BOMs in the context of industrialized house-building is realized.

  • Callou, Dinah
    et al.
    Avelar, Juanito
    University of Campinas, Brazil.
    TER/HAVER constructions and verbal agreement2013In: Journal of Portuguese Linguistics, ISSN 1645-4537, E-ISSN 2397-5563, Vol. 12, no 2, p. 187-208Article in journal (Refereed)
    Abstract [en]

    The aim of this paper is twofold: (i) to analyze the use of the verbs ter and haver in the history of Portuguese and, more specifically, in a recent stage of Brazilian Portuguese, in which the possessive ter is used as an existential verb; and (ii) to discuss some properties involving ter and haver in possessive and existential domains, in both European and Brazilian Portuguese, pointing to the possibility of verbal agreement with ter/haver-existential constructions. Exploring results from previous analyses it is shown that some properties of existential constructions, in contemporary Brazilian Portuguese, can derive from changes involving subject position, related to the weakening of flectional paradigm.

  • Avelar, Juanito
    et al.
    University of Campinas, Brazil.
    Galves, Charlotte
    O papel das línguas africanas na emergência da gramática do português brasileiro2014In: Lingüística, ISSN 1132-0214, Vol. 30, no 2, p. 241-288Article in journal (Refereed)
  • Ornelas de Avelar, Juanito
    University of Campinas, Brazil.
    Sentenças possessivas e existenciais2018In: História do Português Brasileiro: Mudança sintática: perspectiva gerativista / [ed] Ataliba T. de Castilho, Maria A. Torres Morais, Sonia Cyrino, São Paulo: Editora Contexto , 2018, p. 72-49Chapter in book (Refereed)
  • Donzel-Gargand, Olivier
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Thersleff, Thomas
    Stockholm University.
    Keller, Jan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Törndahl, Tobias
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Larsson, Fredrik
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Wallin, Erik
    Solibro Research AB, Uppsala, Sweden.
    Stolt, Lars
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics. Solibro Research AB, Uppsala, Sweden.
    Edoff, Marika
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Electronics.
    Deep surface Cu depletion induced by K in high-efficiency Cu(In,Ga)Se2 solar cell absorbers2018In: Progress in Photovoltaics, ISSN 1062-7995, E-ISSN 1099-159XArticle in journal (Refereed)
    Abstract [en]

    In this work, we used K‐rich glass substrates to provide potassium during the coevaporation of Cu(In,Ga)Se2 (CIGS) absorber layers. Subsequently, we applied a postdeposition treatment (PDT) using KF or RbF to some of the grown absorbers. It was found that the presence of K during the growth of the CIGS layer led to cell effi- ciencies beyond 17%, and the addition of a PDT pushed it beyond 18%. The major finding of this work is the observation of discontinuous 100‐ to 200‐nm‐deep Cu‐ depleted patches in the vicinity of the CdS buffer layer, correlated with the presence of K during the growth of the absorber layer. The PDT had no influence on the forma- tion of these patches. A second finding concerns the composition of the Cu‐depleted areas, where an anticorrelation between Cu and both In and K was measured using scanning transmission electron microscopy. Furthermore, a steeper Ga/(In+Ga) ratio gradient was measured for the absorbers grown with the presence of K, suggesting that K hinders the group III element interdiffusion. Finally, no Cd in‐diffusion to the CIGS layer could be detected. This indicates that if CdCu substitution occurs, either their concentration is below our instrumental detection limit or its presence is contained within the first 6 nm from the CdS/CIGS interface.

  • Käihkö, Ilmari
    Swedish Defence University, Department of Security, Strategy and Leadership (ISSL), Division of Strategy.
    The MODEL social structure of an armed group: From Liberian refugees to heroes of Côte d’Ivoire and liberators of the homeland2018In: Small Wars & Insurgencies, ISSN 0959-2318, E-ISSN 1743-9558, Vol. 29, no 4, p. 776-800Article in journal (Refereed)
    Abstract [en]

    This article investigates the Movement for Democracy in Liberia (MODEL) through a revised Weberian framework that focuses on legitimacy and offers a thick description of the different phases of this armed group. The article argues that the key to fostering cohesion is the harmonization of the micro, meso, and macro levels. This proved a difficult undertaking for the MODEL. Not only did the MODEL lack material resources but it also relied on different and evolving kinds of legitimacy on these levels. With its sources of legitimacy exhausted after the war, the MODEL ceased to exist.

  • Spang, Anja
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab. Royal Netherlands Inst Sea Res, Dept Marine Microbiol & Biogeochem, NIOZ, Den Burg, Netherlands.; Univ Utrecht, Den Burg, Netherlands.
    Eme, Laura
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Saw, Jimmy H.
    Oregon State Univ, Dept Microbiol, Corvallis, OR USA.
    Fernández Cáceres, Eva
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Zaremba-Niedzwiedzka, Katarzyna
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Lombard, Jonathan
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Guy, Lionel
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Ettema, Thijs J. G.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Asgard archaea are the closest prokaryotic relatives of eukaryotes2018In: PLoS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 14, no 3, article id e1007080Article in journal (Other academic)
  • Immonen, Elina
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
    Hämäläinen, Anni
    Univ Alberta, Dept Biol Sci, Edmonton, Canada.
    Schuett, Wiebke
    Univ Hamburg, Inst Zool, Hamburg, Germany.
    Tarka, Maja
    Norwegian Univ Sci & Technol NTNU, Ctr Biodivers Dynam, Dept Biol, Trondheim, Norway.
    Evolution of sex-specific pace-of-life syndromes: genetic architecture and physiological mechanisms2018In: Behavioral Ecology and Sociobiology, ISSN 0340-5443, E-ISSN 1432-0762, Vol. 72, no 3, article id UNSP 60Article, review/survey (Refereed)
    Abstract [en]

    Sex differences in life history, physiology, and behavior are nearly ubiquitous across taxa, owing to sex-specific selection that arises from different reproductive strategies of the sexes. The pace-of-life syndrome (POLS) hypothesis predicts that most variation in such traits among individuals, populations, and species falls along a slow-fast pace-of-life continuum. As a result of their different reproductive roles and environment, the sexes also commonly differ in pace-of-life, with important consequences for the evolution of POLS. Here, we outline mechanisms for how males and females can evolve differences in POLS traits and in how such traits can covary differently despite constraints resulting from a shared genome. We review the current knowledge of the genetic basis of POLS traits and suggest candidate genes and pathways for future studies. Pleiotropic effects may govern many of the genetic correlations, but little is still known about the mechanisms involved in trade-offs between current and future reproduction and their integration with behavioral variation. We highlight the importance of metabolic and hormonal pathways in mediating sex differences in POLS traits; however, there is still a shortage of studies that test for sex specificity in molecular effects and their evolutionary causes. Considering whether and how sexual dimorphism evolves in POLS traits provides a more holistic framework to understand how behavioral variation is integrated with life histories and physiology, and we call for studies that focus on examining the sex-specific genetic architecture of this integration.

  • Hamdan, Mohammed
    et al.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Byström, Pär
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Hotchkiss, Erin R.
    Al-Haidarey, Mohammed J.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Ask, Jenny
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Karlsson, Jan
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Carbon dioxide stimulates lake primary production2018In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 10878Article in journal (Refereed)
    Abstract [en]

    Gross primary production (GPP) is a fundamental ecosystem process that sequesters carbon dioxide (CO2) and forms the resource base for higher trophic levels. Still, the relative contribution of different controls on GPP at the whole-ecosystem scale is far from resolved. Here we show, by manipulating CO2 concentrations in large-scale experimental pond ecosystems, that CO2 availability is a key driver of whole-ecosystem GPP. This result suggests we need to reformulate past conceptual models describing controls of lake ecosystem productivity and include our findings when developing models used to predict future lake ecosystem responses to environmental change.

  • Pierozan, Paula
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Jernerén, Fredrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Karlsson, Oskar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Perfluorooctanoic acid (PFOA) exposure promotes proliferation, migration and invasion potential in human breast epithelial cells2018In: Archives of Toxicology, ISSN 0340-5761, E-ISSN 1432-0738, Vol. 92, no 5, p. 1729-1739Article in journal (Refereed)
    Abstract [en]

    Despite significant advances in early detection and treatment, breast cancer remains a major cause of morbidity and mortality. Perfluorooctanoic acid (PFOA) is a suspected endocrine disruptor and a common environmental pollutant associated with various diseases including cancer. However, the effects of PFOA and its mechanisms of action on hormone-responsive cells remain unclear. Here, we explored the potential tumorigenic activity of PFOA (100 nM-1 mM) in human breast epithelial cells (MCF-10A). MCF-10A cells exposed to 50 and 100 mu M PFOA demonstrated a higher growth rate compared to controls. The compound promoted MCF-10A proliferation by accelerating G(0)/G(1) to S phase transition of the cell cycle. PFOA increased cyclin D1 and CDK4/6 levels, concomitant with a decrease in p27. In contrast to previous studies of perfluorooctane sulfate (PFOS), the estrogen receptor antagonist ICI 182,780 had no effect on PFOA-induced cell proliferation, whereas the PPAR alpha antagonist GW 6471 was able to prevent the MCF-10A proliferation, indicating that the underlying mechanisms involve PPAR alpha-dependent pathways. Interestingly, we also showed that PFOA is able to stimulate cell migration and invasion, demonstrating its potential to induce neoplastic transformation of human breast epithelial cells. These results suggest that more attention should be paid to the roles of PFOA in the development and progression of breast cancer.

  • Berger, Eloise
    et al.
    Delpierre, Cyrille
    Hosnijeh, Fatemeh Saberi
    Kelly-Irving, Michelle
    Portengen, Lutzen
    Bergdahl, Ingvar
    Umeå University, Faculty of Medicine, Department of Biobank Research.
    Johansson, Ann Sofie
    Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
    Krogh, Vittorio
    Palli, Domenico
    Panico, Salvatore
    Sacerdote, Carlotta
    Tumino, Rosario
    Kyrtopoulos, Soterios A.
    Vineis, Paolo
    Chadeau-Hyam, Marc
    Vermeulen, Roel
    Castagné, Raphaële
    Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: findings from two prospective cohorts2018In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 10805Article in journal (Refereed)
    Abstract [en]

    Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflammatory score is associated with breast cancer (BC) and.-cell Non-Hodgkin Lymphoma (B-cell NHL, including 68 multiple myeloma cases) onset. We modelled the relationship between this inflammatory score and the two cancers studied: (BC and B-cell NHL) using generalised linear models, and assessed, through adjustments the role of behaviours and lifestyle factors. Analyses were performed by cancer types pooling both populations, and stratified by cohorts, and time to diagnosis. Our results suggested a lower inflammatory score in B-cell NHL cases (β = -1.28, p = 0.012), and, to lesser, extent with BC (β= -0.96, p = 0.33) compared to controls, mainly driven by cancer cases diagnosed less than 6 years after enrolment. These associations were not affected by subsequent adjustments for potential intermediate confounders, notably behaviours. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated. These observations call for further studies involving larger populations, larger variety of cancer types and repeated measures of larger panel of inflammatory markers.