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  • Disputas: 2019-01-18 13:00 Hörsal 5, hus B, Stockholm
    Fonseca, Max
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Statsvetenskapliga institutionen.
    Your Treatment, My Treat?: On Lifestyle-Related Ill Health and Reasonable Responsibilitarianism2019Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    How should the costs of unhealthy lifestyles be distributed between individual citizens and the state? This study approaches this question by investigating the justifiability of the responsibilitarian idea that people who are responsible for their lifestyle-choices should also be held responsible for the costs that these lifestyle-choices generate.

    Two main conclusions come out of this investigation. The first is that the basic justification of responsibilitarian health policies can be found in what is called the Civic Blame approach to responsibilitarianism. This approach builds upon a moralized conception of responsibility, accountability responsibility. On this conception, the moral quality of contemporary imprudent people’s behaviour is the essential starting point for establishing that they ‘are responsible’. Consequently, what justifies responsibilitarian health policies on this approach is not that imprudent people cause their own ill health or that they exercise sufficient control over their lifestyle-choices, but that they breach reciprocity-based civic obligations through their health-risking behaviour.

    The second conclusion is that the emphasis on fairness of blame/differential treatment inherent in the Civic Blame approach imposes two important justificatory constraints. The first is that the response to the breaches of civic obligations must be properly proportional and context-sensitive in order to be fair. This constraint can most likely be handled however, since a response of the right kind can be found by holding imprudent people responsible via Sin-Taxes (rather than via harsher policies). More problematic for responsibilitarians is the second constraint: to show that contemporary imprudent people’s behaviour is morally problematic to begin with, and, thereby, to show that contemporary prudent people’s reactive attitudes to health-risking behaviour are fair.

    Thus, although the Civic Blame approach outlined in the study provides the basic theoretical building blocks for the justification of responsibilitarian health policies, this approach also provides the tools for critically questioning the justifiability of contemporary health policies of responsibilitarian kind.

  • Disputas: 2019-01-18 13:00 hörsal 11, hus F, Stockholm
    Elmgren, Charlotta
    Stockholms universitet, Humanistiska fakulteten, Engelska institutionen.
    J.M. Coetzee's Poetics of the Child2019Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    This dissertation explores how central tensions in J.M. Coetzee’s fiction converge in and are made visible by the child figure. Its central claim is that the child draws attention to how Coetzee’s poetics is characterized by a constant interplay between responsibility to the other—within and beyond history—on the one hand, and irresponsibility, indeterminacy and play on the other. Key to this argument is Giorgio Agamben’s emancipatory thinking on infancy, or the experience of the impotentiality of language, which can be understood as the capacity to hold thought in suspense. This complements productively those strands of existing Coetzee scholarship that, drawing on Blanchot, Levinas, and Derrida, find in Coetzee’s writing—and in responses to that writing—an ethics of hospitality to an alterity that is always yet to emerge. After an overview of interrelated conceptions and evocations of the child figure in theology, philosophy and literature, the study is organized around five central dynamics of a “poetics of the child” in Coetzee: The first chapter presents the child’s navigation between fictions of the self and of the world in a quest for authenticity as a compelling figure for Coetzee’s writing of fiction in the search for a never available truth of self. The second chapter argues that fictional encounters with “other” child figures within history are ethical in their destabilization of boundaries between self and other and in their foregrounding of ironic remainders made visible through different constructions of the child. In dialogue with Hannah Arendt’s thinking on natality, amor mundi and education, the third chapter shows that the child calls attention to how Coetzee’s working through of the uncertainties of new beginnings is closely linked to a care for the world. Finally, the fourth and fifth chapters engage with how Coetzee’s latest works gesture towards infancy and perpetual study, and, relatedly, towards the redemptive potential of a nonposition beyond the taxonomies of Western metaphysics. Ultimately, the thesis hopes to demonstrate the critical possibilities in thinking about—and with—childlike openness and childish experimentation when approaching the writing and reading of the work of J.M. Coetzee.

  • Disputas: 2019-01-11 13:00 Magnélisalen, Kemiska övningslaboratoriet, Stockholm
    Rzepka, Przemyslaw
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    The chemical nature of CO2 adsorption in zeolite A2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The climate changes are accelerated by increasing levels of carbon dioxide in the atmosphere connected to the fossil-fuel-based energy system. Substantial reforms of the system are needed immediately and could include the implementation of carbon capture and storage (CCS) technologies. Adsorption-driven CO2 capture is one of the most promising post-combustion CO2 capture techniques, which aim to remove CO2 from N2 in flue gas.

    The nature of adsorption of CO2 can vary. The process can act as physisorption with intermolecular interactions of the van der Waals type or as chemisorption with a significantly perturbed electronic structure of CO2 and for example the formation of CO32- and HCO3- species. The molecular details were elucidated by MAS NMR and IR studies for a zeolite, and the placement of adsorbed molecules was revealed by in situ diffraction data analysis.

    Adsorption-driven processes can be implemented only if highly functional adsorbent materials have been developed. Zeolite A seems to be a promising candidate. This thesis broadly discussed the potential enhancement of the selectivity of CO2 over N2 and CH4 by replacing Na+ with larger monovalent cation e.g. K+ in pore apertures of zeolite A. The positions of the extra-framework cations were analyzed by in situ X-ray diffraction using synchrotron light source. The cations were positioned at the 4- and 6-rings and the 8-ring apertures of the aluminosilicate framework of zeolite A. K+ was favored at the 8-ring sites, and this cation did also gradually substitute the 6-ring sites with and increasing x in |Na12-xKx|-A. Large cations did not fit the mirror plane of the 6-ring and were placed on both its sides. K+ at both positions, in 8-rings and 6-rings, seems to have tailored the size of pore openings.

    The effective pore aperture size was shown to depend on the K+ content and to partition small CO2 molecules from large N2 and CH4 because of, likely, differences in diffusivities. Various compositions of |Na12-xKx|-A demonstrated gradual decrease of CO2 uptake with x and an exclusion of N2 and CH4 already for low x. Although already absorbed CO2 molecules were revealed by in situ neutron diffraction to be coordinated mainly by the 8-ring cation or bridging adjacent 8-ring sites. Adsorbed CO2 molecules displaced the cations into the a-cages and resulted in a slight contraction of the overall distribution of extra-framework cations upon the adsorption of CO2.

    The kinetically-enhanced separation of CO2 from N2/CH4 seemed to be associated by a restrained diffusion also for the CO2 molecules. This is problematic for pressure swing adsorption processes. However, it could potentially be addressed by the reduction of size of zeolite crystals to increase the extent of accessible porous space over limited time.

  • Disputas: 2019-01-11 10:00 Vivi Täckholmsalen (Q-salen), NPQ-huset, Stockholm
    Karlsson, Konrad
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och botanik.
    Local adaptation in life history traits and population size estimation of aquatic organisms2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Human society is dependent on healthy aquatic ecosystems for our basic needs and well-being. Therefore, knowledge about how organisms respond and interact with their environments is pivotal. The Baltic Sea is highly affected by human activity and future populations living in its catchment area will have to respond to multiple set of changing abiotic and biotic predictors.

    The first two papers of this thesis focus on local adaptation, adaptive capacity, and the response to changing temperature, salinity, and food conditions of different Eurytemora affinis populations, a ubiquitous zooplankton species in the Baltic Sea. Development time of zooplankton is an important trait and relates to how fast a population can increase in number. Common garden experiments showed that E. affinis populations from warmer southern areas had shorter development time from nauplii to adult at high temperature compared to populations from colder areas, which indicates an adaptation to temperature. The adaptation was explained by a correlation in development time between higher temperatures, 17 and 22.5 °C, while development between a colder temperature, 12 °C, and the two higher temperatures was uncorrelated. This implies that adaption to short development time at high temperature is unlikely for populations originating from cold temperatures. Hence, global warming will be disadvantageous for northern, compared to southern populations. However, development time is heritable and may change under selection, and may improve the competitive advantage of northern populations. The population with the shortest development time had comparably lower survival at high temperature and low food quality. This represents a cost of fast development, and emphasizes the importance of including multiple stressors when investigating potential effects of climate change.

    E. affinis inhabits a broad range of habitats from an epi-benthic life in freshwater lakes and river mouths, to pelagic life in estuaries. Paper III aims to link the morphology of different populations to habitat and resource utilization. Results showed that the individuals of a pelagic population were smaller in size and more slender, compared to a littoral population of larger and more fecund individuals. In experimentally constructed benthic and pelagic algae communities, the littoral population produced less offspring than the pelagic population when filamentous benthic diatoms were included. This suggests that filaments disturb their feeding and that littoral populations of E. affinis stay epi-benthic. As pelagic fish typically select larger prey, living close to the bottom probably allows the littoral population to grow larger than the pelagic. These results link morphology to habitat specialization, and show contrasting ecological effects of two E. affinis populations.

    Paper IV focuses on the recreational angler’s potential role as a citizen scientist. The pike Esox lucius has a stabilizing role in ecosystems as a top consumer and is highly valued by recreational anglers in European lakes and estuaries. Results showed that recreational angling could be used to estimate population size and connectivity of E. lucius in spatial capture-recapture models. The only prerequisite is that anglers practice catch and release, retain spatial data, and take photos of their caught fish. These results show that data from recreational angling can be of potential use for fisheries managers and researchers.

  • Disputas: 2019-01-25 13:00 L 70, NOD-huset, Kista
    Holmberg, Jörgen
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Designing for added pedagogical value: A design-based research study of teachers’ educational design with ICT2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    In an increasingly digitized world teachers are expected to take on the role of educational designers and use ICT to design in ways that add pedagogical value to teaching and learning. This thesis adopts a design-based research (DBR) approach to: (a) explore and contribute to the educational design processes of teachers of English as a foreign language in their efforts to use ICT for added pedagogical value, (b) examine how ICT is used in educational designs to create/contribute to what the teachers and students describe as added value and (c) explore, problematize and refine DBR as a research approach.

    Literature studies and a collaborative self-study preceded the DBR to guide its focus and implementation. The DBR was carried out over a period of two years in four upper secondary schools in Sweden in which every student had access to their own computer. The research data consists of: (a) audio recorded design conversations, (b) enacted educational designs and design elements as parts of these, (c) reflective log entries written by the participating teachers, (d) focus group interviews with students and (e) the researcher’s field notes.

    Six different theoretical frameworks and models are used in combination in the accompanying articles to analyze the data and achieve the three research aims. The findings show how teachers’ pedagogical reasoning and TPACK development are interconnected and reciprocal aspects of the educational design process and how the externalization of, and reflection on, these aspects is necessary to develop the specific and practical TPACK needed to realize design intentions in situated contexts. A number of challenges and opportunities in the educational process have been identified.

    Moreover, the findings show how ICT was used to contribute added value in educational designs by facilitating: (a) more authentic and seamless learning experiences in external online contexts with both in-class and out-of-class actors irrespective of time and place, (b) an exchange of digital knowledge representations of understanding and practice between different actors, e.g. for the purposes of modelling, supporting cognitive apprenticeship, meta-cognitive self-regulation and formative assessment and (c) new and extended forms of, and opportunities for, collaborative creation and meaning-making.

    The current common focus in DBR on the development of prescriptive design principles is problematized in relation to the findings of the thesis, which illustrate the complex and situated nature of the educational design process. A theoretically and empirically informed design framework (DF) is developed and used as a conceptual tool to guide and analyze educational design processes and enactments. The findings illustrate how the use of the DF and the process of collaborative design reflection contributed to the analysis of the teachers’ design intentions and de facto design practices and to a DBR format that allowed the participants to use their respective competencies in the development of educational designs for added value. The thesis thereby serves as an example of how DBR can be methodically implemented to study and generate increased knowledge about teachers’ design intentions and design practices, develop research-based educational designs in line with teachers’ pedagogical intentions and support their development as educational designers.

  • Disputas: 2019-01-25 13:00 Nordenskiöldsalen, Geovetenskapens hus, Stockholm
    Novosel, Ylva
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Barn- och ungdomsvetenskapliga institutionen.
    Transspråkandets triptyk: mot en inkluderande syn på flerspråkighet i förskolan2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Multilingualism is increasing in the Swedish preschool. According to Curriculum for the Preschool, 1998, teachers should ensure that children with another first language than Swedish have the opportunity to develop both Swedish and their first language. Nevertheless this is scarcely done. According to the Swedish Schools Inspectorate, 2017, and prior research from preschools a monolingustic norm is common. Translanguaging is a new way of looking at multilingualism, away from the monolinguistic norm. It is also a way of working with multilingualism in schools and preschools.

    The aim of this thesis is to investigate the applicability of the concept translanguaging in early childhood education, to increase the possibility for an inclusive view on multilingualism, by further expanding the concept using three theoretical perspectives, i.e. constructionism, post humanism and phenomenology.

    The data were gathered through an ethnographic study at a Swedish preschool, where approximately 90 percent of the children were multilingual. Seven multilingual children aged 1 to 5 years were shadowed during a 12 week period in their first semester at preschool, initially using field notes succeeded by video recording. The study was reviewed by an internal ethics committee and all actions were taken in accordance with the Code of Ethics of the Swedish Research Council, 2017.

    The study shows that the children translanguage through different modalities, affect and more-than-human-agents. Translanguaging means using one’s full linguistic repertoire but also, through an expansion of the concept, to create something new. I postulate that using translanguaging as a concept and as a pedagogy in preschool leads towards an inclusive view on multilingualism, opening up for diversity and acknowledging of the competent child.

  • Disputas: 2019-01-25 10:00 Vivi Täckholmsalen (Q-salen), NPQ-huset, Stockholm
    Erlandsson, Rasmus
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen.
    Spatial and temporal population dynamics in the mountain tundra – mesopredator and prey2019Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    It is well known that competition, predation and fluctuating food resources can have strong effect on individual fitness and population dynamics. The complexity of natural systems can make it complicate to disentangle those processes, but environments with relatively simple food webs, and strong cyclic population dynamics offer contrasting conditions resembling experimental treatments. This thesis concerns the spatial and temporal implications of fluctuations in small rodent abundance on two trophic levels in a highly cyclic ecosystem, the Scandinavian mountain tundra. The first two chapters focus on plant biomass and spatiotemporal distribution in the Norwegian lemming (Lemmus lemmus), while the three last papers focus on the direct and indirect effects of small rodent fluctuations and territory quality on reproductive success, juvenile survival and group living in a lemming specialist mesopredator, the arctic fox (Vulpes lagopus). By developing, validating and applying a novel application of aerial photos for remote sensing of plant biomass (Chapter I), we found that food availability predicted lemming distribution during population peaks, but that they were more habitat specific during increase years when intraspecific competition was lower (Chapter II). Arctic fox reproduction is tightly connected to small rodent abundance but the effects of geographical variation in food availability is less well known. We used 17 years of population surveys of an arctic fox subpopulation in mid Sweden (Helagsfjällen) to investigate potential effects. During small rodent increase years, we found that arctic fox litter sizes were smaller in territories of intermediate plant productivity, compared to both more and less productive territories (Chapter III). This could be an effect of limited food availability together with increased presence of red foxes (Vulpes vulpes), a stronger and potentially lethal competitor. However, when small rodents peaked, and competition would be expected to decrease, we saw no effect of territory productivity. Based on a smaller data set concerning juvenile summer survival, we found that the mortality rate among juveniles born by first time breeding arctic fox females were more sensitive to low small rodent prey abundance (Chapter IV). We explain it with an increased predation pressure from top-predators that switch from small rodents to alternative prey when small rodents decline, as suggested by an observed positive effect on juvenile survival by adult presence on den sites. Arctic foxes are socially flexible, and several adults can share a den with the resident pair, potentially increasing juvenile survival and help in territorial defence. Returning to the 17-year data set, we tested the Resource Dispersion Hypothesis predicting that increased resource availability should increase group size (Chapter V). We found support for this prediction as group living increased during the small rodent peak phase. However, it remained unexpectedly high during the decrease phase, when resources are scarce. This could however be related to increased predation pressure, and an increasing benefit of group living.

  • Disputas: 2019-01-25 10:00 De Geersalen, Geovetenskapens hus, Stockholm
    Dunker, Rickard
    Stockholms universitet, Juridiska fakulteten, Juridiska institutionen.
    Lokala ordningsföreskrifter2019Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    In Sweden there are more than 280,000 known ancient and historical remains and monuments (fornminnen), almost 17,500 protected natural areas, 48 certified airports, hundreds of ports and marinas and a very large number of geographical areas which constitutes so-called public place (offentlig plats) or are subject to shoreland protection (strandskydd). For each and every of these places, municipalities and/or some state administrative authorities may issue local ordinances on public order (lokala ordningsföreskrifter), i.e. additional local rules about what persons in the area have to observe concerning “the order” therein. This regulatory power has been used to regulate a wide range of different issues, e.g. consumption of alcohol, diving, gambling, skiing, Christmas decorations, fishing, running, collection of money, parking, supervision over cats, dogs and horses, placarding, demonstrations, photographing, camping, riding, golfing, marketing, barbecuing, boating, begging, moviemaking, goldpanning, climbing, leafleting, taxi services, cycling, smoking and hunting. It also happens that municipal servants or police officers are given extra powers through the local ordinances, e.g. a right to take certain measures against those who do not comply with the rules or to confiscate or forfeit property used in violation with the local decrees.

    The described arrangement and the examples raises many questions, e.g. whether all of these matters actually, with respect to the rest of the legal system, may be handled in local ordinances? If not, what can be regulated? Is there any supervision over the regulatory powers in question, for example whether the provisions are given a legal and appropriate content? How are the ordinances brought to the public's attention? Can the rules be subject to appeal and, if so, by whom and in what order? How do different ordinances regarding public order relate to each other in such geographic areas where they overlap? In this dissertation, this – the Swedish system with local ordinances on public order – is subject to a broad scientific examination.

  • Vartia, Katarina
    Naturvårdsverket. Utförare miljöövervakning, Länsstyrelser, lst, Länsstyrelsen Västra Götalands län.
    Flodpärlmussla i Bratteforsån och Gärebäcken: - status och trender2007Rapport (Annet vitenskapelig)
    Abstract [sv]

    Bratteforsån

    Flodpärlmusselbeståndet i Bratteforsån är liten sett ur ett nationellt perspektiv. Medeltätheten

    är låg men utbredningen är relativt stor även i ett nationellt perspektiv. I Västra Götaland är

    det endast två andra åar som har en lika stor utbredning av musslor.

    Minsta funna mussla i årets inventering var 12 mm. I övrigt påträffades inga musslor mindre

    än 2 respektive 5 cm. Bratteforsån bedöms utifrån årets inventering ligga i skyddsvärdeklass

    II, dvs Bratteforsån har Högt skyddsvärde. Årets undersökning visar en ökning av beståndet

    jämfört med 2000, från 13 000 till 18 000 musslor. Tätheten är på uppgång men anses

    fortfarande vara låg. Musslornas medellängd har under åren 1989 till 2000 stadigt ökat för att

    i år minska. Medeltätheten har mellan 2000 och 2006 ökat på alla lokaler utom två. Fynd av

    en 12 mm lång mussla indikerar att det förekommer viss rekrytering.

    Trots positiv trend i årets undersökning är det viktigt att arbetet med de biotopförbättrande

    åtgärderna fortsätter i Bratteforsån. Vidare bör resurser läggas på rådgivning till

    kringliggande markägare för att minska näringsläckage och erosion till ån. Enskilda avlopp i

    avrinningsområdet bör också ses över.

    Gärebäcken

    Beståndsstorleken i Gärebäcken är liten sett ur ett nationellt perspektiv. Medeltätheten är låg

    och utbredningen är liten. Den minsta funna musslan var 49 mm. I övrigt fanns inga musslor

    mindre än 2 respektive 5 cm. Gärebäcken bedöms utifrån årets inventering ligga i

    skyddsvärdeklass I, dvs Gärebäcken är Skyddsvärd. Musselbeståndet hade i år minskat

    jämfört med beståndet år 1999, från cirka 3 200 till cirka 3 000 musslor. Tätheten visar på

    nedgång och musslornas medellängd har ökat. Medeltätheten har mellan 1999 och 2006

    minskat på sju lokaler. En ökning med avseende på medeltätheten har skett på sex lokaler. På

    de två lokaler där det inte var någon skillnad fanns inga musslor alls. Minsta påträffade

    musslan var 49 mm.

    Årets undersökning antyder en negativ trend vad gäller musselpopulationen i Gärebäcken. Det

    är viktigt att arbeta med biotopförbättrande åtgärder i Gärebäcken. Vidare bör resurser läggas

    på rådgivning till kringliggande markägare för att minska näringsläckage och erosion till ån.

    Dessutom bör enskilda avlopp i avrinningsområdet ses över.

  • Dibitetto, Giuseppe
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik.
    Passias, Achilleas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik.
    AdS(2) x S-7 solutions from D0-F1-D8 intersections2018Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 10, artikkel-id 190Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We study an exhaustive analytic class of massive type IIA backgrounds pre-serving sixteen real supercharges and enjoying SL(2, ) x SO(8) bosonic symmetry. The corresponding geometry is described by AdS(2) x S-7 warped over a line, which turns out to emerge from taking the near-horizon limit of D0-F1-D8 intersections. By studying the singularity structure of these solutions we find the possible presence of localized O8/D8 sources, as well as of fundamental strings smeared over the S-7. Finally we discuss the relation between the aforementioned solutions and the known AdS(7) x S-2 class through double analytic continuation.

  • Danielsson, Linda
    Naturvårdsverket. Utförare miljöövervakning, Länsstyrelser, lst, Länsstyrelsen Västra Götalands län.
    Försurningskänsligt grundvatten i Västra Götalands län: Utvärdering av undersökningar 1985-20142018Rapport (Annet vitenskapelig)
    Abstract [sv]

    I Västra Götalands län har regional miljöövervakning av försurningskänsligt grundvatten huvudsakligen utförts sedan 1990-talet. Övervakningsprogrammet har de senaste åren omfattat ca 20 intensiva provpunkter, som har provtagits årligen. Under perioden 2005-2010 omfattade programmet även ca 110 extensiva prov-punkter, som har provtagits vart 5:e år. En utvärdering av programmet för försur-ningskänsligt grundvatten har gjorts för att se hur miljötillståndet har förändrats över tid samt för att kunna anpassa programmet till de nya kraven på uppföljning av antropogen påverkan.

    Analysdata för länet har hämtats från Sveriges Geologiska Undersöknings (SGU) databas för miljöövervakning, dit Länsstyrelsen har rapporterat sina analysdata. En statistisk bearbetning av analysdata har sedan utförts i form av medelvärdes- och trendberäkningar. De framräknade medelvärdena har jämförts med bedömnings-grunder från 2013. När resultaten studeras är det viktigt att komma ihåg att de stat-ioner som har provtagits främst är utvalda för att representera förhållanden i länet som har liten mänsklig påverkan. Nedan presenteras slutsatserna från dessa beräk-ningar.

    Det kan i stort sett inte utläsas några geografiska skillnader för länet utifrån medel-värdesberäkningarna, förutom för natrium och klorid där medelhalterna är något högre i fd Göteborg och Bohus län. Det kan inte heller förväntas någon geografisk bundenhet med hänsyn till det sätt som stationerna har valts ut, förutom närheten till kusten som ger högre tillskott av natrium, klorid och sulfat. Generellt är kon-duktiviteten och kloridhalterna låga till måttliga i länet.

    Värdena för alkalinitet, som är ett mått på motståndskraften mot försurning, be-döms generellt som mycket låga till måttliga. Det innebär att alkaliniteten är otill-räcklig för att ge ett stabilt och acceptabelt pH-värde (SGU, 2013).

    Sulfathalterna i länet är låga till måttliga. Måttliga halter tyder på att grundvattnet är påverkat av tidigare svaveldeposition.

    Kalcium-, magnesium och kaliumhalterna är generellt mycket låga till låga i länet. För magnesium finns det dock ganska många stationer med måttlig halt i fd Göte-borg och Bohus län. Natriumhalterna är huvudsakligen mycket låga till måttliga och stationerna närmast havet visar generellt på måttliga halter. I grundvatten kan förhöjda halter av baskatjoner (kalcium, magnesium, kalium och natrium) visa på att marken har genomgått en försurningsprocess (SGU, 2013), men det finns även andra processer som kan leda till måttliga till höga halter, exempelvis kalkrik berg-grund.

    Nitrathalterna varierar generellt över länet från mycket låga till höga. Höga eller mycket höga nitrathalter beror oftast på jordbrukspåverkan, men det kan även bero på enskilda avlopp.

    När det gäller tungmetaller så är halterna av arsenik, kadmium och kvicksilver generellt mycket låga till låga, medan blyhalterna varierar mer.

    6

    Trendberäkningarna visar att för länet som helhet syns för perioden 1997-2014 generellt ökande alkalinitet, kalium- och magnesiumhalter, medan sulfathalterna och konduktiviteten minskar. Vid den tidigare utvärderingen 2005 var det ett fåtal stationer som visade på en signifikant ökande trend för alkalinitet. Vid utvärdering-en nu visar drygt hälften av de ingående stationerna på en ökande trend för alkali-nitet, vilket tyder på att grundvattnets buffringskapacitet mot försurande ämnen ökar. Sulfathalterna fortsätter att minska, vilket visar på en minskande försur-ningspåverkan. När det gäller baskatjonerna så var det främst minskande halter 2005, men för kalium och magnesium är nu trenden ökande eller signifikant ökande för flera stationer. För kalcium och natrium är trenderna både ökande och minskande.

    Rapporten omfattar även en översyn av det nuvarande provtagningsprogrammet. Syftet med det nya provtagningsprogrammet kommer även fortsatt vara att följa förändringar över tid i grundvattnets kemiska sammansättning med inriktning mot försurning. Övervakning av antropogen påverkan kommer att ske inom ett annat delprogram nämligen "Grundvatten påverkat av tätort och jordbruk". Provtagning kommer fortsättningsvis att ske enbart under hösten och antalet provtagningsstat-ioner kommer att bli något färre än tidigare, ca 17. Programmet delas in i två delar en del med grundvatten med låg jonstyrka i jordlager för att följa försurningen samt några stationer i berggrunden. Parametrarna kommer att vara ungefär desamma som tidigare.

  • Disputas: 2019-01-18 09:15 Polhemsalen, Uppsala
    Eklund, Petter
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Elektricitetslära.
    Design of Rare Earth Free Permanent Magnet Generators2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Low speed permanent magnet (PM) synchronous generators (SGs) are commonly used in renewable energy. Rare earth (RE) PMs such as neodymium-iron-boron are a popular choice due to their high performance. In 2011 supply and cost issues were added to the previously existing environmental concerns regarding REPM raw materials as the world's major producer China imposed export restrictions. This thesis aims to investigate and propose design solutions for PMSGs that do not use REPMs. Two approaches are used: to design generators using the cheaper and more abundant ferrite PM materials, and to investigate how properties of new PM materials influence SG design.

    A ferrite PM rotor is designed to replace a REPM rotor in an experimental 12 kW wind power generator. The new design employs a flux concentrating spoke type rotor to achieve performance similar to the old REPM rotor while using ferrite PMs. The ferrite PM rotor design is built. The air gap length, magnetic flux density in the air gap, PM remanence, and voltage at both load and no load are measured. The generator has lower no load voltage than expected, which is mainly explained by lower than specified remanence of the ferrite PMs in the prototype. With the measured remanence inserted into the calculations some discrepancy remains. It is found that the discrepancy can be explained by the magnetic leakage flux in the end regions of the spoke type rotor, which is not modeled in the two dimensional simulations used for the design calculations.

    To investigate the influence of PM material properties three different PM rotor topologies are optimized for torque production using PM materials described by their remanence, recoil permeability, and demagnetization resistance. Demagnetization is considered using currents determined by a novel, winding design independent short circuit model. It is found that the spoke type rotor gives the highest torque of the three rotor topologies for low remanence materials as long as the PMs have sufficient demagnetization resistance. For high remanence materials the surface mounted PM rotor can give higher torque if the demagnetization resistance is high, but otherwise a capped PM rotor gives higher torque.

  • Montero, José Amenedo
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Österlund, Lars
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Photodegradation of Stearic Acid Adsorbed on Copper Oxide Heterojunction Thin Films Prepared by Magnetron Sputtering2018Inngår i: ChemEngineering, Vol. 2, nr 3, artikkel-id 40Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Nanocrystalline copper oxide thin films were fabricated by reactive DC magnetron sputtering. The structure and optical properties of the films were measured with X-ray diffraction, scanning electron microscopy, and spectrophotometry. Variations of oxygen partial pressure resulted in oxide composition ranging from Cu, Cu-Cu2O, Cu2O-CuO1−x, and CuO. Optical band transitions at 2.06 eV and 2.55 eV were found for Cu2O corresponding to the direct forbidden and direct allowed interband transitions. For CuO an indirect allowed interband transition was found at 1.28 eV. The photocatalytic activity was determined by quantifying the rate constant and quantum yield (destroyed molecules/photons absorbed) under stearic acid degradation. Photocatalytic activity was found to be highest in mixed-phase films with Cu-Cu2O films the highest. Results from post-annealed Cu-Cu2O and CuO films show similar results. We interpret our results as being due to efficient electron-hole charge separation in the heterojunction films. The obtained quantum yields were generally about ten times lower than for comparable dense TiO2 and WO3 binary oxides, which calls for further studies of the spectral dependence of the quantum yield and electron-hole pair life times for oxides with different purity levels.

  • Larsson, Johanna
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Fysikundervisningens didaktik. Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Centrum för genusvetenskap.
    Airey, John
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Fysikundervisningens didaktik. Department of Mathematics and Science Education, Stockholm University, Stockholm, Sweden.
    Danielsson, Anna
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Fakulteten för utbildningsvetenskaper, Institutionen för pedagogik, didaktik och utbildningsstudier. Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Centrum för genusvetenskap.
    Lundqvist, Eva
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Fakulteten för utbildningsvetenskaper, Institutionen för pedagogik, didaktik och utbildningsstudier.
    A Fragmented Training Environment: Discourse Models in the Talk of Physics Teacher Educators2018Inngår i: Research in science education, ISSN 0157-244X, E-ISSN 1573-1898Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article reports the results of an empirical study exploring the discourses of physics teacher educators. We ask how the expressed understandings of a physics teacher education programme in the talk of teacher educators potentially support the identity construction of new teachers. Nine teacher educators from different sections of a physics teacher programme in Sweden were interviewed. The concept of discourse models was used to operationalise how the discourses of the teacher education programme potentially enable the performance of different physics teacher identities. The analysis resulted in the construction of four discourse models that could be seen to be both enabling and limiting the kinds of identity performances trainee physics teachers can enact. Knowledge of the models thus potentially empowers trainee physics teachers to understand the different goals of their educational programme and from there make informed choices about their own particular approach to becoming a professional physics teacher. We also suggest that for teacher educators, knowledge of the discourse models could facilitate making conscious, informed decisions about their own teaching practice.

  • Andersson, Jörgen
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Rosell, M.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap.
    Kockum, Karin
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Söderström, Lars
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap.
    Laurell, Katarina
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Challenges in diagnosing normal pressure hydrocephalus: evaluation of the diagnostic guidelines2017Inngår i: eNeurologicalSci, ISSN 2405-6502, Vol. 7, s. 27-31Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose: To evaluate the present diagnostic guidelines of idiopathic normal pressure hydrocephalus (iNPH) in a sample from the general population.

    Methods: A total of 168 individuals (93 females, 75 males), mean age 75 years (range 66-92) with and without symptoms of iNPH underwent a CT-scan of the brain, a neurological examination with assessment of the triad symptoms, i.e. gait disturbances, memory impairment and urgency incontinence. The participants were then diagnosed as "unlikely", "possible" and "probable" iNPH according to the American-European and the Japanese guidelines, respectively. Separately, a senior consultant in neurology diagnosed each patient based on the overall clinical picture.

    Results: Obtaining a diagnosis of "probable iNPH" was three times more likely according to the American-European guidelines (n = 35) compared to the Japanese guidelines (n = 11) or the neurologist (n = 11). The concordance was highest (Kappa = 0.69) between the Japanese guidelines and the neurologist.

    Conclusions: Considerable discrepancies were found when diagnosing iNPH according to two international guidelines and a neurologist, respectively. The Japanese guidelines, which include a minimum of two triad symptoms, were most concordant with the neurologist. As a step towards widely accepted, standardized diagnostic criteria, we suggest a revision of the current guidelines, preferably into one common diagnostic system.

  • Bernhard, Jonte
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Carstensen, Anna-Karin
    School of Engineering, Jönköping University Jönköping, Sweden.
    “Real” experiments or computers in labs – opposites or synergies?: Experiences from a course in electric circuit theory2017Inngår i: Proceedingsof the 45th SEFI Annual Conference 2017 Education Excellence for Sustainability: Education Excellence for Sustainability / [ed] José Carlos Quadrado, Jorge Bernardino, João Rocha, Bryssels: SEFI – Société Européenne pour la Formation des Ingénieurs , 2017, s. 1300-1307Konferansepaper (Fagfellevurdert)
    Abstract [en]

    In this study we report from our experiences designing and re-designing a lab where engineering students studied transient response in electric circuits. In the first version of the lab students had difficulties doing the mathematical modeling of the experimentally measured graphs as it required students’ to link the time- and frequency domains as well as the object/event and theory/model worlds simultaneously. In the re-designed lab some computer simulations were included together with the original experiments on real circuits. The simulations opened up for learning and enabled students to establish links that are hard access directly with real experiments.Still doing real experiments is important to secure students ability to make links between models and theories and the physical reality. This study demonstrates that synergetic learning effects can be achieved by a careful design using an insightful combination of real experiments and computer simulations.  Hence, we propose that the question of “real” experiments or “virtual” labs using computer simulations are best for students’ learning is not an either or question. Rather, it is a question of finding the right blend to achieve synergetic effects.

  • Nikulina, Varvara
    et al.
    Blekinge Tekniska Högskola, Fakulteten för teknikvetenskaper, Institutionen för strategisk hållbar utveckling. Blekinge Institute of Technology.
    Baumann, Henrikke
    Chalmers University of Technology, SWE.
    Simon, David
    Mistra Urban Futures, SWE.
    Sprei, Frances
    Chalmers University of Technology, SWE.
    Sustainable Transport Futures: Analysis of the Selected Methodologies Supporting the Planning Process Towards Achieving Goal 11 Sustainable Cities and Communities2018Inngår i: Handbook of Sustainability Science and Research / [ed] W. Leal Filho, Springer, 2018, s. 473-488Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    A quarter of energy-related greenhouse gas emissions (GHG) originate from the transportation sector. Continuously increasing demand for transportation services worldwide is one of the main urban challenges addressed by Sustainable Development Goal 11, target 2. One way to address this issue is to develop an integrated transportation system that can ensure confidence and comfort for the passengers. This will contribute not only to the customers’ experience but also to operators and authorities through sustainable, cost-effective, and profitable services. Conversely, the lack of such a system or a poorly managed system prevents the economy and society from realizing its potential. In the transition towards sustainability, the planning process of complex systems such as transportation often requires supportive tools and methods, such as futures methodologies that assist decision-making by providing information about possible futures. In today’s rapidly changing environment, forecasting tools do not always provide the expected outcomes since it is difficult to predict all the unexpected events. Therefore, there is a demand for alternative methods that not only grasp the constant changes but also create additional value (for example, meeting the needs of multisectoral collaboration and creation of common vision). The present article investigates the usefulness of three such methodologies, namely backcasting, foresighting, and SymbioCity, for the planning process of the bus park and railway station in Kisumu, Kenya, and Centralen in Gothenburg, Sweden. The paper’s contribution is a description of the Kenyan transportation system (which has not been studied in detail before), planning process, and pertinent issues related to the stations both in Kisumu and Gothenburg, located in the sharply contrasting contexts of global South and global North, respectively. On the basis of field research, interviews, and feasibility study of futures methodologies, the paper concludes that backcasting is the most suitable of the methodologies for both places, since it can be applied at a small scale, and provides creative solutions and has a high level of integration of stakeholders. Furthermore, the paper examines the application of the futures methodologies in multisectoral urban transitions apart from transportation and draws conclusion on what can be learnt from it.

  • Di Baldassarre, Giuliano
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Luft-, vatten och landskapslära. Ctr Nat Hazards & Disaster Sci CNDS, Uppsala, Sweden.
    Kreibich, Heidi
    GFZ German Res Ctr Geosci, D-14473 Potsdam, Germany.
    Vorogushyn, Sergiy
    GFZ German Res Ctr Geosci, D-14473 Potsdam, Germany.
    Aerts, Jeroen
    Vrije Univ Amsterdam, Inst Environm Studies, NL-1081 Amsterdam, Netherlands.
    Arnbjerg-Nielsen, Karsten
    Tech Univ Denmark, Dept Environm Engn, DK-2800 Lyngby, Denmark.
    Barendrecht, Marlies
    Vienna Univ Technol, Ctr Water Resource Syst, A-1040 Vienna, Austria.
    Bates, Paul
    Univ Bristol, Sch Geog Sci, Bristol BS8 1SS, Avon, England.
    Borga, Marco
    Univ Padua, Dept Land Environm Agr & Forestry, I-35122 Padua, Italy.
    Botzen, Wouter
    Vrije Univ Amsterdam, Inst Environm Studies, NL-1081 Amsterdam, Netherlands;Univ Utrecht, Sch Econ USE, Utrecht, Netherlands.
    Bubeck, Philip
    Univ Potsdam, Inst Earth & Environm Sci, D-14469 Potsdam, Germany.
    De Marchi, Bruna
    Univ Bergen, Ctr Study Sci & Humanities, SVT, N-5020 Bergen, Norway.
    Llasat, Carmen
    Univ Barcelona, Dept Appl Phys, E-08007 Barcelona, Spain.
    Mazzoleni, Maurizio
    IHE Delft, Dept Integrated Water Syst & Governance, NL-2601 Delft, Netherlands.
    Molinari, Daniela
    Politecn Milan, Dept Civil & Environm Engn, I-20133 Milan, Italy.
    Mondino, Elena
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Luft-, vatten och landskapslära. Ctr Nat Hazards & Disaster Sci CNDS, Uppsala, Sweden.
    Mård, Johanna
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Luft-, vatten och landskapslära. Ctr Nat Hazards & Disaster Sci CNDS, Uppsala, Sweden.
    Petrucci, Olga
    CNR, Res Inst Geohydrol Protect, CNR, I-87036 Arcavacata Di Rende, CS, Italy.
    Scolobig, Anna
    Swiss Fed Inst Technol, Dept Environm Syst Sci, CH-8092 Zurich, Switzerland.
    Viglione, Alberto
    Vienna Univ Technol, Ctr Water Resource Syst, A-1040 Vienna, Austria.
    Ward, Philip J.
    Vrije Univ Amsterdam, Inst Environm Studies, NL-1081 Amsterdam, Netherlands.
    Hess Opinions: An interdisciplinary research agenda to explore the unintended consequences of structural flood protection2018Inngår i: Hydrology and Earth System Sciences, ISSN 1027-5606, E-ISSN 1607-7938, Vol. 22, nr 11, s. 5629-5637Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    One common approach to cope with floods is the implementation of structural flood protection measures, such as levees or flood-control reservoirs, which substantially reduce the probability of flooding at the time of implementation. Numerous scholars have problematized this approach. They have shown that increasing the levels of flood protection can attract more settlements and high-value assets in the areas protected by the new measures. Other studies have explored how structural measures can generate a sense of complacency, which can act to reduce preparedness. These paradoxical risk changes have been described as "levee effect", "safe development paradox" or "safety dilemma". In this commentary, we briefly review this phenomenon by critically analysing the intended benefits and unintended effects of structural flood protection, and then we propose an interdisciplinary research agenda to uncover these paradoxical dynamics of risk.

  • Kleberg, Johan L.
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Nyström, Pär
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Bölte, Sven
    Karolinska Institutet.
    Falck-Ytter, Terje
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Uppsala universitet, Kollegiet för avancerade studier (SCAS). Department of Women’s and Children’s Health, Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Stockholm, Sweden .
    Sex Differences in Social Attention in Infants at Risk for Autism2018Inngår i: Journal of autism and developmental disorders, ISSN 0162-3257, E-ISSN 1573-3432Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We studied visual attention to emotional faces in 10-month-old infant siblings of children with ASD (ASD-sibs; N = 70) and a siblings of typically developing children (N = 29) using static stimuli. Contrary to our predictions, we found no evidence for atypical gaze behavior in ASD-sibs when boys and girls were analyzed together. However, a sex difference was found in ASD-sibs' visual attention to the mouth. Male ASD-sibs looked more at the mouth across emotions compared to male controls and female ASD-sibs. In contrast, female ASD-sibs looked less at the mouth compared to female controls. These findings suggest that some aspects of early emerging atypical social attention in ASD-sibs may be sex specific.

  • Alström, Per
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi. Swedish Univ Agr Sci SLU, Swedish Species Informat Ctr, Box 7007, S-75007 Uppsala, Sweden; Chinese Acad Sci, Inst Zool, Key Lab Zool Systemat & Evolut, Beijing 100101, Peoples R China.
    Rasmussen, Pamela C.
    Michigan State Univ, Dept Integrat Biol, E Lansing, MI 48864 USA;Michigan State Univ, MSU Museum, E Lansing, MI 48864 USA;Nat Hist Museum Tring, Bird Grp, Akeman St, Tring HP23 6AP, England.
    Xia, Canwei
    Beijing Normal Univ, Minist Educ, Coll Life Sci, Key Lab Biodivers & Ecol Engn, Beijing 100875, Peoples R China.
    Gelang, Magnus
    Gothenburg Nat Hist Museum, Box 7283, S-40235 Gothenburg, Sweden.
    Liu, Yang
    Sun Yat Sen Univ, Sch Life Sci, Dept Ecol, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China.
    Chen, Guoling
    Sun Yat Sen Univ, Sch Life Sci, Dept Ecol, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China.
    Zhao, Min
    Chinese Acad Sci, Inst Zool, Key Lab Zool Systemat & Evolut, Beijing 100101, Peoples R China;Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
    Hao, Yan
    Chinese Acad Sci, Inst Zool, Key Lab Zool Systemat & Evolut, Beijing 100101, Peoples R China;Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
    Zhao, Chao
    Cloud Mt Conservat, Dali 671003, Yunnan, Peoples R China.
    Zhao, Jian
    Sun Yat Sen Univ, Sch Life Sci, Dept Ecol, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China.
    Yao, Chengte
    COA, Endem Species Res Inst, High Altitude Expt Stn, Chi Chi 55244, Taiwan.
    Eaton, James A.
    Birdtour Asia, 17 Keats Ave, Derby DE23 4EE, England.
    Hutchinson, Robert
    Birdtour Asia, 17 Keats Ave, Derby DE23 4EE, England.
    Lei, Fumin
    Chinese Acad Sci, Inst Zool, Key Lab Zool Systemat & Evolut, Beijing 100101, Peoples R China.
    Olsson, Urban
    Univ Gothenburg, Dept Biol & Environm Sci, Systemat & Biodivers, Box 463, S-40530 Gothenburg, Sweden.
    Taxonomy of the White-browed Shortwing (Brachypteryx montana) complex on mainland Asia and Taiwan: an integrative approach supports recognition of three instead of one species2018Inngår i: Avian Research, ISSN 0005-2175, E-ISSN 2053-7166, Vol. 9, artikkel-id 34Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The White-browed Shortwing (Brachypteryx montana) is widespread from the central Himalayas to the southeast Chinese mainland and the island of Taiwan, the Philippines and Indonesia. Multiple subspecies are recognised, and several of these have recently been suggested to be treated as separate species based on differences in morphology and songs.

    Methods: We here analyse plumage, morphometrics, songs, two mitochondrial and two nuclear markers, and geographical distributions of the two mainland Asian taxa B. m. cruralis and B. m. sinensis and the Taiwanese B. m. goodfellowi.

    Results: We conclude that these differ congruently in morphology, songs and DNA. Male B. m. goodfellowi is the most divergent in plumage (sexually monomorphic, unlike the two others; male similar to female), and B. m. cruralis and B. m. sinensis differ in male plumage maturation. The song of B. m. cruralis is strongly divergent from the others, whereas the songs of B. m. sinensis and B. m. goodfellowi are more similar to each other. Brachypteryx m. sinensis and B. m. goodfellowi are sisters, with an estimated divergence time 4.1 million years ago (mya; 95% highest posterior distribution [HPD] 2.8-5.5mya), and B. m. cruralis separated from these two 5.8mya (95% HPD 4.1-7.5mya). We also report notable range extensions of B. m. sinensis as well as sympatry between this taxon and B. m. cruralis in Sichuan Province, China. Brachypteryx m. montana from Java is found to be more closely related to Lesser Shortwing (B. leucophris) and Rusty-bellied Shortwing (B. hyperythra) than to the mainland Asian and Taiwanese taxa.

    Conclusion: Our data support a recent proposal to treat the three mainland Asian and Taiwanese taxa as three species, separate from B. montana sensu stricto: B. cruralis (central Himalayas to south central China and south Vietnam), B. sinensis (north central to southeastern part of mainland China) and B. goodfellowi (Taiwan Island).

  • Martinsson, Olof
    et al.
    Luleå University of Technology.
    Bergman, Stefan
    Sveriges geologiska undersökning.
    Persson, Per-Olof
    Naturhistoriska riksmuseet, Enheten för geovetenskap.
    Hellström, Fredrik
    Sveriges geologiska undersökning.
    Age and character of late-Svecokarelian monzonitic intrusions in northeastern Norrbotten, northern Sweden2018Inngår i: SGU Rapporter och meddelanden, ISSN 0349-2176, Vol. 141, s. 381-400Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Palaeoproterozoic magmatism in northern Norrbotten shows a complex evolution, with several different plutonic suites ranging in age 1.93–1.70 Ga. Here we present data for three monzonitic intrusions from different parts of the area. They are petrographically and chemically similar, consisting mainly of perthite, augite and orthopyroxene, with megacrysts of poikilitic biotite as a characteristic minor component, and with high Sr and Ba. The intrusions have been dated at 1.80 Ga and may be part of a more extensive magmatic event in northern Sweden, including other chemically similar monzonitic and gabbroic intrusions, which often occur as ring dykes at the Merasjärvi gravity high (MGH) in northeastern Norrbotten. The monzonitic intrusions have A-type signatures and chemical characteristics overlapping those of rocks in arc and within-plate settings. These intrusions may thus have formed in either a back arc setting related to eastward subduction associated with the Transscandinavian Igneous Belt further west (TIB 1), or through a separate igneous event caused by a mantle plume.

  • Lynch, Edward
    et al.
    Sveriges geologiska undersökning.
    Bauer, Tobias
    Luleå University of Technology.
    Jörnberger, Johan
    Sveriges geologiska undersökning.
    Smarlus, Zmar
    Luleå University of Technology.
    Morris, George
    Sveriges geologiska undersökning.
    Persson, Per-Olof
    Naturhistoriska riksmuseet, Enheten för geovetenskap.
    Petrological and structural character of c. 1.88 Ga meta-volcanosedimentary rocks hosting iron oxide-copper-gold and related mineralisation in the Nautanen–Aitik area, northern Sweden2018Inngår i: SGU Rapporter och meddelanden, ISSN 0349-2176, Vol. 141, s. 107-150Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The petrological and deformation characteristics of a Palaeoproterozoic meta-volcanosedimentary sequence in the Nautanen–Aitik area (near Gällivare, northern Sweden) are presented. The investigated sequence (part of the Muorjevaara group) predominantly comprises metavolcaniclastic rocks displaying variable grain size, textural and syn-depositional features (e.g. grading, cross-laminae, compositional banding). Locally, poorly sorted agglomerate-like horizons with coarser clasts (lapilli-to block-size) occur. Interbedded sections of mainly fine-grained, volcanogenic (epiclastic) metasedimentary rocks contain syn-depositional features that suggest a sub-aqueous, relatively shallow depositional environment. Locally preserved cross-laminae in this unit provide evidence of way-up and paleocurrent directions. Intercalations of pelite, mica schist and amphibolitic schist also occur throughout the sequence. In general, least altered samples indicate a predominantly intermediate (basaltic andesitic to andesitic), calc-alkaline composition for the sequence.

    U-Pb SIMS zircon dating of a meta-andesite horizon, intercalated within the sequence, has yielded a precise U-Pb concordia age of 1 878 ± 7 Ma (2σ, n = 12). This date constrains the timing of intermediate volcanism and the deposition of syn-volcanic epiclastic material. By inference, it also provides an estimate for the age of Muorjevaara group rocks hosting the Nautanen Cu-Au and Aitik Cu-Au-Ag deposits. When combined with lithogeochemical signatures, the new age also confirms a genetic link between the metavolcaniclastic package and gabbroic to dioritic intrusions in the area (e.g. the c. 1.88 Ga Aitik stock). Additionally, several zircon cores record 207Pb/206Pb apparent ages between c. 1.90 and 1.89 Ga, suggesting inheritance of marginally older volcanic ± plutonic material not exposed at the present erosion level.

    The Nautanen–Aitik area contains the roughly north-northwest-trending Nautanen deformation zone (NDZ), a major composite brittle-ductile structure hosting hydrothermal iron oxide-Cu-Au (IOCG)-style mineralisation (e.g. the Nautanen deposit). Here, the bedrock is relatively intensely altered and sheared, and has been transposed into a sub-parallel high-strain zone predominantly consisting of a composite planar penetrative fabric. Outside the high-strain zone, relatively large-scale approximately north-northwest-aligned folds and discordant brittle structures occur. Magnetic susceptibility and VLF-resistivity modelling of the NDZ confirm that composite planar structures mainly dip steeply to the west-southwest and continue at depth.

  • Lynch, Edward
    et al.
    Sveriges geologiska undersökning.
    Hellström, Fredrik
    Sveriges geologiska undersökning.
    Huhma, Hannu
    Geological survey of Finland.
    Jörnberger, Johan
    Sveriges geologiska undersökning.
    Persson, Per-Olof
    Naturhistoriska riksmuseet, Enheten för geovetenskap.
    Morris, George
    Sveriges geologiska undersökning.
    Geology, lithostratigraphy and petrogenesis of c. 2.14 Ga greenstones in the Nunasvaara and Masugnsbyn areas, northernmost Sweden2018Inngår i: SGU Rapporter och meddelanden, ISSN 0349-2176, Vol. 141, s. 19-77Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Two Palaeoproterozoic greenstone successions in the Nunasvaara and Masugnsbyn areas of north-central Norrbotten (northernmost Sweden) have been investigated to (1) characterise their primary depositional features; (2) establish lithostratigraphic correlations between both areas; and (3) gain insights into the petrogenesis of greenstone-type volcano-sedimentary successions in this sector of the Fennoscandian Shield.

    In the Nunasvaara area (Vittangi greenstone group), a partly conformable, polydeformed, approxi­mately 2.4 km thick greenstone sequence mainly consists of basaltic (tholeiitic) metavolcanic and metavolcaniclastic rocks (amygdaloidal lava, laminated tuff). Intercalated metasedimentary units include graphite-bearing black schist, and pelite. The uppermost part consists of amphibolitic pelite with intercalated metacarbonate layers and rare meta-ironstone, metachert and meta-ultrabasic horizons. Numerous metadoleritic sills occur throughout the package.

    In the Masugnsbyn area (Veikkavaara greenstone group) a relatively conformable approximately 3.4 km thick greenstone sequence displays lithological, geochemical and geophysical characteristics similar to that at Nunasvaara. This succession consists of a dominant basaltic metatuff sequence over­lain by metasedimentary units towards the top (e.g. meta-ironstone, metachert, amphibolitic schist, calcitic and dolomitic marbles). Minor metadolerite sills occur in the metatuffs. Near the base of the metatuff package, a graphitic black schist horizon occupies a similar stratigraphic position to a prom­inent black schist layer at Nunasvaara (here named the Nunasvaara member). This unit is a key mark­er horizon providing lateral correlation between both successions and also acts as a useful strain marker for reconstructing deformational events.

    Both greenstone successions record the effects of overprinting syn-to late-orogenic (Svecokarelian) tectonothermal events. These include complex, polyphase ductile deformation (D1 to D3 events at Nunasvaara, forming the Nunasvaara dome), peak amphibolite facies metamorphism, metasomatic-hydrothermal alteration and late-stage retrogression and brittle faulting (composite D4 at Nunasvaara). Locally, these overprinting processes formed metamorphic graphite, skarn-related Fe ± Cu and hydro­thermal Cu ± Pb ± Mo mineralisation.

    U-Pb SIMS zircon dating of a metadolerite dyke from Nunasvaara and a metadolerite sill from Masugnsbyn have yielded mean weighted 207Pb/206Pb ages of 2 144 ±5 Ma (2σ, n = 10) and 2 139 ±4 Ma (2σ, n = 5) Ma, respectively. These precise dates constrain the timing of hypabyssal mafic magmatism, provide a minimum age for the deposition of the volcanic and sedimentary rocks, and identify a new approximetly 2.14 Ga episode of tholeiitic magmatism in this sector of the Fennoscandian Shield. Whole-rock initial εNd values for greenstone meta-igneous units range from +0.4 to +4.0 at Nunasvaara (n = 11) and +0.4 to +3.7 at Masugnsbyn (n = 7). These data indicate a juvenile depleted to partly enriched mantle (asthenospheric or lithospheric) as a major source of the tholeiitic melts. Corresponding trace element systematics have enriched mid-ocean ridge (E-MORB)-type signatures, and indicate minor assimilation of Archaean continental crust (i.e. Norrbotten craton) during magma ascent and storage. Overall, the combined geological, geochemical and isotopic characteristics of the greenstones are consistent with protolith formation within an incipient oceanic basin (epieric Norrbotten Seaway) during approximetly 2.14 Ga rifting and sagging of the Norrbotten craton.

  • Schell, Carl Otto
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Karolinska Inst, Dept Publ Hlth Sci, Global Hlth Hlth Syst & Policy, Stockholm, Sweden.
    Warnberg, Martin Gerdin
    Karolinska Inst, Dept Publ Hlth Sci, Global Hlth Hlth Syst & Policy, Stockholm, Sweden.
    Hvarfner, Anna
    Uppsala Univ, Fac Med, Uppsala, Sweden.
    Hoog, Andreas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD).
    Baker, Ulrika
    Karolinska Inst, Dept Publ Hlth Sci, Global Hlth Hlth Syst & Policy, Stockholm, Sweden;Coll Med, Blantyre, Malawi.
    Castegren, Markus
    Karolinska Univ Hosp, Perioperat Med & Intens Care PMI, Stockholm, Sweden.
    Baker, Tim
    Karolinska Inst, Dept Publ Hlth Sci, Global Hlth Hlth Syst & Policy, Stockholm, Sweden;Coll Med, Blantyre, Malawi;Karolinska Univ Hosp, Perioperat Med & Intens Care PMI, Stockholm, Sweden.
    The global need for essential emergency and critical care2018Inngår i: Critical Care, ISSN 1364-8535, E-ISSN 1466-609X, Vol. 22, artikkel-id 284Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    Critical illness results in millions of deaths each year. Care for those with critical illness is often neglected due to a lack of prioritisation, co-ordination, and coverage of timely identification and basic life-saving treatments. To improve care, we propose a new focus on essential emergency and critical care (EECC)care that all critically ill patients should receive in all hospitals in the world. Essential emergency and critical care should be part of universal health coverage, is appropriate for all countries in the world, and is intended for patients irrespective of age, gender, underlying diagnosis, medical specialty, or location in the hospital. Essential emergency and critical care is pragmatic and low-cost and has the potential to improve care and substantially reduce preventable mortality.

  • Heinig, Stefanie
    et al.
    KTH, Skolan för elektro- och systemteknik (EES), Elkraftteknik.
    Jacobs, Keijo
    KTH, Skolan för elektro- och systemteknik (EES), Elkraftteknik.
    Ilves, Kalle
    KTH, Skolan för elektro- och systemteknik (EES), Elkraftteknik. ABB Corporate Research.
    Norrga, Staffan
    KTH, Skolan för elektro- och systemteknik (EES), Elkraftteknik.
    Nee, Hans-Peter
    KTH, Skolan för elektro- och systemteknik (EES), Elkraftteknik.
    Implications of Capacitor Voltage Imbalance on the Operation of the Semi-Full-Bridge Submodule2017Inngår i: 2017 19th European Conference on Power Electronics andApplications (EPE'17 ECCE Europe), Warsaw, Poland, 2017Konferansepaper (Fagfellevurdert)
    Abstract [en]

    An investigation of the voltage imbalance of the two capacitors of the semi-full-bridge submodule is performed. Since the capacitances are not exactly the same, there may be a difference between the capacitor voltages. The resulting current-spike when they are connected in parallel has been analyzed in a full-scale laboratory experiment.

  • Lentina, Alda Maria
    Högskolan Dalarna, Akademin Humaniora och medier, Portugisiska.
    A Quinta-Essência de Agustina Bessa-Luís : l’Asie portugaise2018Inngår i: Carnet de l’École Doctorale Histoire de l’art et Archéologie de Sorbonne Université,, Vol. 1, s. 1-8Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [fr]

    Dans A Quinta Essência Agustina Bessa-Luís nous propose une lecture originale de l’Histoire portugaise postcoloniale, en réinvestissant les thèmes de l’interculturel et de la rencontre avec l’Autre. En effet, dans le contexte trouble d’avril 1974, le personnage de José Carlos Pessanha s’expatrie vers l’Orient, en particulier vers Macao, l’une des dernières colonies orientales de l’Empire colonial portugais. Or, la particularité de ce périple de redécouverte de l’Orient est qu’il fait coïncider la destinée d’un personnage en quête de soi avec celle d’un pays se questionnant encore sur sa propre identité. Ainsi, dans ce voyage à rebours dans l’Histoire luso-orientale, l’auteure dessine le visage d’une Nation-Empire tiraillée à la fois entre le désir d’incarner cette « supériorité génétique de l’Occident » et une fascination pour la culture de l’Autre, signe d’un « excès d’altérité » (B. de Sousa Santos) dans l’identité portugaise. Macao, terre de l’entre-deux et de la circulation interculturelle, sera le terrain propice et emblématique à l’expression de la position « ambivalente et hybride » (colonisateur/colonisé) du Portugal en Occident.

  • Bachmann, M. Consuelo
    et al.
    Pontificia Univ Catolica Chile, Fac Med, Dept Med Intens, Santiago, Chile;Acute Resp & Crit Illness Ctr ARCI, Santiago, Chile.
    Morais, Caio
    Univ Sao Paulo, Inst Coracao Incor, Hosp Clin, Div Pneumol,Fac Med, Sao Paulo, Brazil.
    Bugedo, Guillermo
    Pontificia Univ Catolica Chile, Fac Med, Dept Med Intens, Santiago, Chile;Acute Resp & Crit Illness Ctr ARCI, Santiago, Chile.
    Bruhn, Alejandro
    Pontificia Univ Catolica Chile, Fac Med, Dept Med Intens, Santiago, Chile;Acute Resp & Crit Illness Ctr ARCI, Santiago, Chile.
    Morales, Arturo
    Pontificia Univ Catolica Chile, Fac Med, Dept Enfermedades Resp, Santiago, Chile.
    Batista Borges, João
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård. Univ Sao Paulo, Inst Coracao Incor, Hosp Clin, Div Pneumol,Fac Med, Sao Paulo, Brazil.
    Costa, Eduardo
    Univ Sao Paulo, Inst Coracao Incor, Hosp Clin, Div Pneumol,Fac Med, Sao Paulo, Brazil.
    Retamal, Jaime
    Pontificia Univ Catolica Chile, Fac Med, Dept Med Intens, Santiago, Chile;Acute Resp & Crit Illness Ctr ARCI, Santiago, Chile.
    Electrical impedance tomography in acute respiratory distress syndrome2018Inngår i: Critical Care, ISSN 1364-8535, E-ISSN 1466-609X, Vol. 22, artikkel-id 263Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Acute respiratory distress syndrome (ARDS) is a clinical entity that acutely affects the lung parenchyma, and is characterized by diffuse alveolar damage and increased pulmonary vascular permeability. Currently, computed tomography (CT) is commonly used for classifying and prognosticating ARDS. However, performing this examination in critically ill patients is complex, due to the need to transfer these patients to the CT room. Fortunately, new technologies have been developed that allow the monitoring of patients at the bedside. Electrical impedance tomography (EIT) is a monitoring tool that allows one to evaluate at the bedside the distribution of pulmonary ventilation continuously, in real time, and which has proven to be useful in optimizing mechanical ventilation parameters in critically ill patients. Several clinical applications of EIT have been developed during the last years and the technique has been generating increasing interest among researchers. However, among clinicians, there is still a lack of knowledge regarding the technical principles of EIT and potential applications in ARDS patients. The aim of this review is to present the characteristics, technical concepts, and clinical applications of EIT, which may allow better monitoring of lung function during ARDS.

  • Porten, Egmont
    et al.
    Mittuniversitetet, Fakulteten för naturvetenskap, teknik och medier, Avdelningen för matematik och ämnesdidaktik.
    Boggess, Al
    Arizona State University, Tempe, AZ, U.S.A.
    Dwilewicz, Roman
    Cardinal Stefan Wyszy´nski University, Warsaw, Poland.
    On the Hartogs extension theorem for unbounded domains in Cn2018Rapport (Annet vitenskapelig)
    Abstract [en]

    Let Ω ⊂ Cn, n ≥ 2, be a domain with smooth connected boundary. IfΩ is relatively compact, the Hartogs-Bochner theorem ensures that everyCR distribution on ∂Ω has a holomorphic extension to Ω. For unboundeddomains this extension property may fail, for example if Ω contains a complex hypersurface. The main result in this paper tells that the extensionproperty holds if and only if the envelope of holomorphy of Cn\Ω is Cn.It seems that it is a first result in the literature which gives a geometriccharacterization of unbounded domains in Cnfor which the Hartogs phenomenon holds. Comparing this to earlier work by the first two authorsand Z. S lodkowski, one observes that the extension problem sensitively depends on a finer geometry of the contact of a complex hypersurface andthe boundary of the domain.

  • Beven, Keith
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Luft-, vatten och landskapslära. Lancaster Environment Centre, Lancaster University, Lancaster, UK.
    Almeida, Susana
    Univ Bristol, Dept Civil Engn, Bristol, Avon, England.
    Aspinall, Willy P.
    Univ Bristol, Sch Earth Sci, Bristol, Avon, England.
    Bates, Paul D.
    Univ Bristol, Sch Geog Sci, Bristol, Avon, England.
    Blazkova, Sarka
    TG Masaryk Water Resource Inst, Prague, Czech Republic.
    Borgomeo, Edoardo
    Univ Oxford, Environm Change Inst, Oxford, England.
    Freer, Jim
    Univ Bristol, Sch Geog Sci, Bristol, Avon, England.
    Goda, Katsuichiro
    Univ Bristol, Dept Civil Engn, Bristol, Avon, England.
    Hall, Jimw.
    Univ Oxford, Environm Change Inst, Oxford, England.
    Phillips, Jeremy C.
    Univ Bristol, Sch Earth Sci, Bristol, Avon, England.
    Simpson, Michael
    Univ Oxford, Environm Change Inst, Oxford, England.
    Smith, Paul J.
    Univ Lancaster, Lancaster Environm Ctr, Lancaster, England;Waternumbers Ltd, Halton Mill, Lancaster LA2 6DN, England.
    Stephenson, David B.
    Univ Exeter, Dept Math & Comp Sci, Exeter, Devon, England.
    Wagener, Thorsten
    Univ Bristol, Dept Civil Engn, Bristol, Avon, England;Univ Bristol, Cabot Inst, Bristol, Avon, England.
    Watson, Matt
    Univ Bristol, Sch Earth Sci, Bristol, Avon, England.
    Wilkins, Kate L.
    Univ Bristol, Sch Earth Sci, Bristol, Avon, England.
    Epistemic uncertainties and natural hazard risk assessment - Part 1: A review of different natural hazard areas2018Inngår i: Natural hazards and earth system sciences, ISSN 1561-8633, E-ISSN 1684-9981, Vol. 18, nr 10, s. 2741-2768Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    This paper discusses how epistemic uncertainties are currently considered in the most widely occurring natural hazard areas, including floods, landslides and debris flows, dam safety, droughts, earthquakes, tsunamis, volcanic ash clouds and pyroclastic flows, and wind storms. Our aim is to provide an overview of the types of epistemic uncertainty in the analysis of these natural hazards and to discuss how they have been treated so far to bring out some commonalities and differences. The breadth of our study makes it difficult to go into great detail on each aspect covered here; hence the focus lies on providing an overview and on citing key literature. We find that in current probabilistic approaches to the problem, uncertainties are all too often treated as if, at some fundamental level, they are aleatory in nature. This can be a tempting choice when knowledge of more complex structures is difficult to determine but not acknowledging the epistemic nature of many sources of uncertainty will compromise any risk analysis. We do not imply that probabilistic uncertainty estimation necessarily ignores the epistemic nature of uncertainties in natural hazards; expert elicitation for example can be set within a probabilistic framework to do just that. However, we suggest that the use of simple aleatory distributional models, common in current practice, will underestimate the potential variability in assessing hazards, consequences, and risks. A commonality across all approaches is that every analysis is necessarily conditional on the assumptions made about the nature of the sources of epistemic uncertainty. It is therefore important to record the assumptions made and to evaluate their impact on the uncertainty estimate. Additional guidelines for good practice based on this review are suggested in the companion paper (Part 2).

  • Karimi, Masoud
    et al.
    Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden.
    von Salome, Jenny
    Karolinska Univ Hosp, Dept Clin Genet, S-17176 Stockholm, Sweden;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Aravidis, Christos
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik.
    Silander, Gustav
    Norrlands Univ Hosp, Dept Clin Genet, Umea, Sweden.
    Askmalm, Marie Stenmark
    Linkopings Univ Hosp, Dept Clin Genet, Linkoping, Sweden;Off Med Serv, Dept Clin Genet, Div Lab Med, Lund, Sweden.
    Henriksson, Isabelle
    Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden;Off Med Serv, Dept Clin Genet, Div Lab Med, Lund, Sweden.
    Gebre-Medhin, Samuel
    Lund Univ, Div Clin Genet, Dept Lab Med, Lund, Sweden;Off Med Serv, Dept Clin Genet, Div Lab Med, Lund, Sweden.
    Frodin, Jan-Erik
    Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden.
    Bjorck, Erik
    Karolinska Univ Hosp, Dept Clin Genet, S-17176 Stockholm, Sweden;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Lagerstedt-Robinson, Kristina
    Karolinska Univ Hosp, Dept Clin Genet, S-17176 Stockholm, Sweden;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Lindblom, Annika
    Karolinska Univ Hosp, Dept Clin Genet, S-17176 Stockholm, Sweden;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Tham, Emma
    Karolinska Univ Hosp, Dept Clin Genet, S-17176 Stockholm, Sweden;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    A retrospective study of extracolonic, non-endometrial cancer in Swedish Lynch syndrome families2018Inngår i: Hereditary Cancer in Clinical Practice, ISSN 1731-2302, E-ISSN 1897-4287, Vol. 16, artikkel-id 16Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BackgroundLynch Syndrome is an autosomal dominant cancer syndrome caused by pathogenic germ-line variants in one of the DNA-mismatch-repair (MMR) genes MLH1, MSH2, MSH6 or PMS2. Carriers are predisposed to colorectal and endometrial cancer, but also other cancer types. The purpose of this retrospective study was to characterize the tumour spectrum of the Swedish Lynch syndrome families.MethodsData were obtained from genetically verified 235 Lynch families from five of the six health care regions in Sweden. The material was stratified for gender, primary cancer, age and mutated gene and the relative proportions of specific cancer types were compared to those in the general population.ResultsA total of 1053 family members had 1493 cancer diagnoses of which 1011 were colorectal or endometrial cancer. Individuals with pathogenic variants in MLH1 and MSH2 comprised 78% of the cohort. Among the 482 non-colorectal/non-endometrial cancer diagnoses, MSH2 carriers demonstrated a significantly increased proportion of urinary tract, gastric, small bowel, ovarian and non-melanoma skin cancer compared to the normal population. MLH1 carriers had an elevated proportion of gastrointestinal cancers (gastric, small bowel, pancreas), while MSH6 carriers had more ovarian cancer than expected. Gastric cancer was predominantly noted in older generations.ConclusionLynch syndrome confers an increased risk for multiple cancers other than colorectal and endometrial cancer. The proportions of other cancers vary between different MMR genes, with highest frequency in MSH2-carriers. Gender and age also affect the tumour spectrum, demonstrating the importance of additional environmental and constitutional parameters in determining the predisposition for different cancer types.

  • Nilson, Tomas
    et al.
    Mittuniversitetet, Fakulteten för naturvetenskap, teknik och medier, Avdelningen för matematik och ämnesdidaktik.
    Schiebold, Cornelia
    Mittuniversitetet, Fakulteten för naturvetenskap, teknik och medier, Avdelningen för matematik och ämnesdidaktik. Uniwersytet Jana Kochanowskiego w Kielcach, Poland.
    Solution formulas for the two-dimensional Toda lattice and particle-like solutions with unexpected asymptotic behaviour2018Rapport (Annet vitenskapelig)
    Abstract [en]

    The first main aim of this article is to derive an explicit solution formula for the scalar 2d-Toda lattice depending on three independent operator parameters, ameliorating work in [29]. This is achieved by studying a noncommutative version of the two-dimensional Toda lattice, generalizing its soliton solution to the noncommutative setting.

    The purpose of the applications part is to show that the family of solutions obtained from matrix data exhibits a rich variety of asymptotic behaviour. The first indicator is that web structures, studied extensively in the literature, see [4] and references therein, are a subfamily. Then three further classes of solutions (with increasingly unusual behaviour) are constructed, and their asymptotics are derived. 

  • Lindblad, Sofia
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Organisk kemi. Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.
    Mehmeti, Krenare
    Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.
    Veiga, Alberte X.
    Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden;Concept Life Sci, Discovery Pk,Ramsgate Rd, Sandwich CT13 9ND, Kent, England.
    Nekoueishahraki, Bijan
    Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.
    Grafenstein, Jurgen
    Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden.
    Erdélyi, Máté
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Organisk kemi. Univ Gothenburg, Dept Chem & Mol Biol, SE-41296 Gothenburg, Sweden; Swedish NMR Ctr, Medicinaregatan 5C, SE-41390 Gothenburg, Sweden.
    Halogen Bond Asymmetry in Solution2018Inngår i: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 140, nr 41, s. 13503-13513Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Halogen bonding is the noncovalent interaction of halogen atoms in which they act as electron acceptors. Whereas three-center hydrogen bond complexes, [D center dot center dot center dot H center dot center dot center dot D](+) where D is an electron donor, exist in solution as rapidly equilibrating asymmetric species, the analogous halogen bonds, [D center dot center dot center dot X center dot center dot center dot D](+), have been observed so far only to adopt static and symmetric geometries. Herein, we investigate whether halogen bond asymmetry, i.e., a [D-X center dot center dot center dot D](+) bond geometry, in which one of the D-X bonds is shorter and stronger, could be induced by modulation of electronic or steric factors. We have also attempted to convert a static three-center halogen bond complex into a mixture of rapidly exchanging asymmetric isomers, [D center dot center dot center dot X-D](+) (sic) [D-X center dot center dot center dot D](+), corresponding to the preferred form of the analogous hydrogen bonded complexes. Using N-15 NMR, IPE NMR, and DFT, we prove that a static, asymmetric geometry, [D-X center dot center dot center dot D](+), is obtained upon desymmetrization of the electron density of a complex. We demonstrate computationally that conversion into a dynamic mixture of asymmetric geometries, [D center dot center dot center dot X-D](+) (sic) [D-X center dot center dot center dot D](+), is achievable upon increasing the donor-donor distance. However, due to the high energetic gain upon formation of the three-center-four electron halogen bond, the assessed complex strongly prefers to form a dimer with two static and symmetric three-center halogen bonds over a dynamic and asymmetric halogen bonded form. Our observations indicate a vastly different preference in the secondary bonding of H+ and X+. Understanding the consequences of electronic and steric influences on the strength and geometry of the three-center halogen bond provides useful knowledge on chemical bonding and for the development of improved halonium transfer agents.

  • Algady, Walid
    et al.
    Univ Leicester, Dept Genet & Genome Biol, Leicester LE1 7RH, Leics, England.
    Louzada, Sandra
    Wellcome Sanger Inst, Cambridge CB10 1SA, England.
    Carpenter, Danielle
    Univ Leicester, Dept Genet & Genome Biol, Leicester LE1 7RH, Leics, England.
    Brajer, Paulina
    Univ Leicester, Dept Genet & Genome Biol, Leicester LE1 7RH, Leics, England.
    Farnert, Anna
    Karolinska Inst, Dept Med Solna, Div Infect Dis, S-17176 Stockholm, Sweden;Karolinska Univ Hosp, Dept Infect Dis, S-17176 Stockholm, Sweden.
    Rooth, Ingegerd
    Natl Inst Med Res, Nyamisati Malaria Res, Dar Es Salaam, Tanzania.
    Ngasala, Billy
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH), Internationell barnhälsa och nutrition. Muhimbili Univ Hlth & Allied Sci, Dept Parasitol & Med Entomol, Dar Es Salaam, Tanzania.
    Yang, Fengtang
    Wellcome Sanger Inst, Cambridge CB10 1SA, England.
    Shaw, Marie-Anne
    Univ Leeds, Leeds Inst Med Res St Jamess, Leeds LS9 7TF, W Yorkshire, England.
    Hollox, Edward J.
    Univ Leicester, Dept Genet & Genome Biol, Leicester LE1 7RH, Leics, England.
    The Malaria-Protective Human Glycophorin Structural Variant DUP4 Shows Somatic Mosaicism and Association with Hemoglobin Levels2018Inngår i: American Journal of Human Genetics, ISSN 0002-9297, E-ISSN 1537-6605, Vol. 103, nr 5, s. 769-776Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Glycophorin A and glycophorin B are red blood cell surface proteins and are both receptors for the parasite Plasmodium falciparum, which is the principal cause of malaria in sub-Saharan Africa. DUP4 is a complex structural genomic variant that carries extra copies of a glycophorin A-glycophorin B fusion gene and has a dramatic effect on malaria risk by reducing the risk of severe malaria by up to 40%. Using fiber-FISH and Illumina sequencing, we validate the structural arrangement of the glycophorin locus in the DUP4 variant and reveal somatic variation in copy number of the glycophorin B-glycophorin A fusion gene. By developing a simple, specific, PCR-based assay for DUP4, we show that the DUP4 variant reaches a frequency of 13% in the population of a malaria-endemic village in southeastern Tanzania. We genotype a substantial proportion of that village and demonstrate an association of DUP4 genotype with hemoglobin levels, a phenotype related to malaria, using a family-based association test. Taken together, we show that DUP4 is a complex structural variant that may be susceptible to somatic variation and show that DUP4 is associated with a malarial-related phenotype in a longitudinally followed population.

  • Fuertes, Elaine
    et al.
    ISGlobal, Barcelona, Spain;Univ Pompeu Fabra UPF, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain;Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England.
    Markevych, Iana
    Ludwig Maximilians Univ Munchen, Univ Hosp, Inst & Clin Occupat Social & Environm Med, Munich, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany.
    Jarvis, Deborah
    Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England;Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England.
    Vienneau, Danielle
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland;Univ Basel, Basel, Switzerland.
    de Hoogh, Kees
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland;Univ Basel, Basel, Switzerland.
    Maria Anto, Josep
    ISGlobal, Barcelona, Spain;Univ Pompeu Fabra UPF, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.
    Bowatte, Gayan
    Univ Melbourne, Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia.
    Bono, Roberto
    Univ Turin, Dept Publ Hlth & Pediat, Turin, Italy.
    Corsico, Angelo G.
    IRCCS Policlin San Matteo Fdn, Div Resp Dis, Pavia, Italy;Univ Pavia, Dept Internal Med & Therapeut, Pavia, Italy.
    Emtner, Margareta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Gislason, Thorarinn
    Landspitali Univ Hosp Reykjavik, Dept Resp Med & Sleep, Reykjavik, Iceland.
    Antonio Gullon, Jose
    Hosp San Agustin, Dept Pneumol, Aviles, Asturias, Spain.
    Heinrich, Joachim
    Imperial Coll London, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, London, England;Ludwig Maximilians Univ Munchen, Univ Hosp, Inst & Clin Occupat Social & Environm Med, Munich, Germany.
    Henderson, John
    Univ Bristol, Britsol Med Sch, Populat Hlth Sci, Bristol, Avon, England.
    Holm, Mathias
    Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.
    Johannessen, Ane
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.
    Leynaert, Benedicte
    INSERM, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Paris, France;Univ Paris Diderot Paris, UMR 1152, Paris, France.
    Marcon, Alessandro
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Marchetti, Pierpaolo
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy.
    Martinez Moratalla, Jesus
    Complejo Hosp Univ Albacete CHUA, Serv Neumol, Albacete, Spain;Serv Salud Castilla La Mancha SESCAM, Castilla La Mancha, Spain;Univ Castilla La Mancha, Fac Med Albacete, Albacete, Spain.
    Pascual, Silvia
    OSI Barrualde Galdakao, Galdakao Hosp, Resp Dept, Biscay, Spain.
    Probst-Hensch, Nicole
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland;Univ Basel, Dept Publ Hlth, Basel, Switzerland.
    Luis Sanchez-Ramos, Jose
    Univ Huelva, Dept Nursing, Huelva, Spain.
    Siroux, Valerie
    UGA, Inst Adv Biosci, Team Environm Epidemiol Appl Reprod & Resp Hlth, Inserm,U1209,CNRS,UMR 5309, Grenoble, France.
    Sommar, Johan
    Umea Univ, Dept Publ Hlth & Clin Med, Occupat & Environm Med, Umea, Sweden.
    Weyler, Joost
    Univ Antwerp, Epidemiol & Social Med, Antwerp, Belgium.
    Kuenzli, Nino
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland;Univ Basel, Basel, Switzerland.
    Jacquemin, Benedicte
    ISGlobal, Barcelona, Spain;Univ Pompeu Fabra UPF, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain;Inst Med Sante & Rech Med, U1168, VIMA Aging & Chron Dis Epidemiol & Publ Hlth Appr, Villejuif, France;Univ Versailles St Quentin En Yvelines, UMR S1168, Versailles, France.
    Garcia-Aymerich, Judith
    ISGlobal, Barcelona, Spain;Univ Pompeu Fabra UPF, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain.
    Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study2018Inngår i: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 120, s. 364-372Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Very few studies have examined whether a long-term beneficial effect of physical activity on lung function can be influenced by living in polluted urban areas.

    Objective: We assessed whether annual average residential concentrations of nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters < 2.5 mu m (PM2.5) and < 10 mu m (PM10) modify the effect of physical activity on lung function among never- (N = 2801) and current (N = 1719) smokers in the multi-center European Community Respiratory Health Survey. Methods: Associations between repeated assessments (at 27-57 and 39-67 years) of being physically active (physical activity: >= 2 times and >= 1 h per week) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were evaluated using adjusted mixed linear regression models. Models were conducted separately for never-and current smokers and stratified by residential long-term NO2, PM2.5 mass and PM10 mass concentrations (<= 75th percentile (low/medium) versus > 75th percentile (high)).

    Results: Among current smokers, physical activity and lung function were positively associated regardless of air pollution levels. Among never-smokers, physical activity was associated with lung function in areas with low/medium NO2, PM2.5 mass and PM10 mass concentrations (e.g. mean difference in FVC between active and non-active subjects was 43.0 mL (13.6, 72.5), 49.5 mL (20.1, 78.8) and 49.7 mL (18.6, 80.7), respectively), but these associations were attenuated in high air pollution areas. Only the interaction term of physical activity and PM10 mass for FEV1 among never-smokers was significant (p-value = 0.03).

    Conclusions: Physical activity has beneficial effects on adult lung function in current smokers, irrespective of residential air pollution levels in Western Europe. Trends among never-smokers living in high air pollution areas are less clear.

  • Nilsson Ekdahl, Kristina
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi. Linnaeus Univ, Ctr Biomat Chem, Kalmar, Sweden.
    Persson, Barbro
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Mohlin, Camilla
    Linnaeus Univ, Ctr Biomat Chem, Kalmar, Sweden.
    Sandholm, Kerstin
    Linnaeus Univ, Ctr Biomat Chem, Kalmar, Sweden.
    Skattum, Lillemor
    Lund Univ, Dept Lab Med Clin Immunol & Transfus Med, Sect Microbiol Immunol & Glycobiol, Lund, Sweden.
    Nilsson, Bo
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Interpretation of Serological Complement Biomarkers in Disease2018Inngår i: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 9, artikkel-id 2237Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Complement systemaberrations have been identified as pathophysiological mechanisms in a number of diseases and pathological conditions either directly or indirectly. Examples of such conditions include infections, inflammation, autoimmune disease, as well as allogeneic and xenogenic transplantation. Both prospective and retrospective studies have demonstrated significant complement-related differences between patient groups and controls. However, due to the low degree of specificity and sensitivity of some of the assays used, it is not always possible to make predictions regarding the complement status of individual patients. Today, there are three main indications for determination of a patient's complement status: (1) complement deficiencies (acquired or inherited); (2) disorders with aberrant complement activation; and (3) C1 inhibitor deficiencies (acquired or inherited). An additional indication is to monitor patients on complement-regulating drugs, an indication which may be expected to increase in the near future since there is now a number of such drugs either under development, already in clinical trials or in clinical use. Available techniques to study complement include quantification of: (1) individual components; (2) activation products, (3) function, and (4) autoantibodies to complement proteins. In this review, we summarize the appropriate indications, techniques, and interpretations of basic serological complement analyses, exemplified by a number of clinical disorders.

  • Aaboud, M.
    et al.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Brenner, Richard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael U. F.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Öhman, Henrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Zwalinski, L.
    Measurement of colour flow using jet-pull observables in in t(t)over-bar events with the ATLAS experiment at root s=13TeV2018Inngår i: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 78, nr 10, artikkel-id 847Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Previous studies have shown that weighted angular moments derived from jet constituents encode the colour connections between partons that seed the jets. This paper presents measurements of two such distributions, the jet-pull angle and jet-pull magnitude, both of which are derived from the jet-pull angular moment. The measurement is performed in delivered by the Large Hadron Collider. The observables are measured for two dijet systems, corresponding to the colour-connected daughters of the Wboson and the two b-jets from the top-quark decays, which are not expected to be colour connected. To allow the comparison of the measured distributions to colour model predictions, the measured distributions are unfolded to particle level, after correcting for experimental effects introduced by the detector. While good agreement can be found for some combinations of predictions and observables, none of the predictions describes the data well across all observables.

  • Aaboud, M.
    et al.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Brenner, Richard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Öhman, Henrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Zwalinski, L.
    Search for R-parity-violating supersymmetric particles in multi-jet final states produced in p-p collisions at root s=13 TeV using the ATLAS detector at the LHC2018Inngår i: Physics Letters B, ISSN 0370-2693, E-ISSN 1873-2445, Vol. 785, s. 136-158Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Results of a search for gluino pair production with subsequent R-parity-violating decays to quarks are presented. This search uses 36.1 fb(-1) of data collected by the ATLAS detector in proton-proton collisions with a centre-of-mass energy of root s = 13 TeV at the LHC. The analysis is performed using requirements on the number of jets and the number of jets tagged as containing a b-hadron as well as a topological observable formed by the scalar sum of masses of large-radius jets in the event. No significant excess above the expected Standard Model background is observed. Limits are set on the production of gluinos in models with the R-parity-violating decays of either the gluino itself (direct decay) or the neutralino produced in the R-parity-conserving gluino decay (cascade decay). In the gluino cascade decay model, gluino masses below 1850 GeV are excluded for 1000 GeV neutralino mass. For the gluino direct decay model, the 95% confidence level upper limit on the cross section times branching ratio varies between 0.80 fb at m((g) over tilde) = 900 GeV and 0.011 fb at m((g) over tilde) = 1800 GeV. (c) 2018 The Author. Published by Elsevier B.V. This is an open access article under the CC BY license.

  • Rose, Max
    et al.
    DESY, Notkestr 85, D-22607 Hamburg, Germany.
    Bobkov, Sergey
    Natl Res Ctr, Kurchatov Inst, Akad Kurchatova Pl 1, Moscow 123182, Russia.
    Ayyer, Kartik
    Ctr Free Electron Laser Sci CFEL, Notkestr 85, D-22607 Hamburg, Germany.
    Kurta, Ruslan P.
    European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany.
    Dzhigaev, Dmitry
    DESY, Notkestr 85, D-22607 Hamburg, Germany.
    Kim, Young Yong
    DESY, Notkestr 85, D-22607 Hamburg, Germany.
    Morgan, Andrew J.
    Ctr Free Electron Laser Sci CFEL, Notkestr 85, D-22607 Hamburg, Germany.
    Yoon, Chun Hong
    SLAC Natl Accelerator Lab, Linac Coherent Light Source, 2575 Sand Hill Rd, Menlo Pk, CA 94025 USA.
    Westphal, Daniel
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Bielecki, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik. European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany.
    Sellberg, Jonas A.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik. KTH Royal Inst Technol, AlbaNova Univ Ctr, Dept Appl Phys, Biomed & Xray Phys, SE-10691 Stockholm, Sweden.
    Williams, Garth
    Brookhaven Natl Lab, 98 Rochester St, Shirley, NY 11967 USA.
    Maia, Filipe R.N.C.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik. Lawrence Berkeley Natl Lab, NERSC, Berkeley, CA USA.
    Yefanov, Olexander M.
    Ctr Free Electron Laser Sci CFEL, Notkestr 85, D-22607 Hamburg, Germany.
    Ilyin, Vyacheslav
    Natl Res Ctr, Kurchatov Inst, Akad Kurchatova Pl 1, Moscow 123182, Russia.
    Mancuso, Adrian P.
    European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany.
    Chapman, Henry N.
    Ctr Free Electron Laser Sci CFEL, Notkestr 85, D-22607 Hamburg, Germany.
    Hogue, Brenda G.
    Arizona State Univ, Biodesign Inst, Biodesign Ctr Immunotherapy Vaccines & Virotherap, Tempe, AZ 85287 USA;Arizona State Univ, Biodesign Inst, Biodesign Ctr Appl Struct Discovery, Tempe, AZ 85287 USA;Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA.
    Aquila, Andrew
    SLAC Natl Accelerator Lab, Linac Coherent Light Source, 2575 Sand Hill Rd, Menlo Pk, CA 94025 USA.
    Barty, Anton
    Ctr Free Electron Laser Sci CFEL, Notkestr 85, D-22607 Hamburg, Germany.
    Vartanyants, Ivan A.
    DESY, Notkestr 85, D-22607 Hamburg, Germany;Natl Res Nucl Univ, MEPhI Moscow Engn Phys Inst, Kashirskoe Shosse 31, Moscow 115409, Russia.
    Single-particle imaging without symmetry constraints at an X-ray free-electron laser2018Inngår i: IUCrJ, ISSN 0972-6918, E-ISSN 2052-2525, Vol. 5, s. 727-736Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The analysis of a single-particle imaging (SPI) experiment performed at the AMO beamline at LCLS as part of the SPI initiative is presented here. A workflow for the three-dimensional virus reconstruction of the PR772 bacteriophage from measured single-particle data is developed. It consists of several well defined steps including single-hit diffraction data classification, refined filtering of the classified data, reconstruction of three-dimensional scattered intensity from the experimental diffraction patterns by orientation determination and a final three-dimensional reconstruction of the virus electron density without symmetry constraints. The analysis developed here revealed and quantified nanoscale features of the PR772 virus measured in this experiment, with the obtained resolution better than 10 nm, with a clear indication that the structure was compressed in one direction and, as such, deviates from ideal icosahedral symmetry.

  • Danielsson, Frida
    et al.
    Royal Inst Technol, Sci Life Lab, S-17165 Stockholm, Sweden.
    Peterson, McKenzie Kirsten
    Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84112 USA.
    Araujo, Helena Caldeira
    Univ Madeira, Ctr Quim, P-9020105 Funchal, Portugal.
    Lautenschlaeger, Franziska
    Saarland Univ, Leibniz Inst Neue Mat gGmbH INM & Expt Phys, NT Fac, Campus D2 2,E 2 6, D-66123 Saarbrucken, Germany.
    Gad, Annica Karin Britt
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Univ Madeira, Ctr Quim, P-9020105 Funchal, Portugal.
    Vimentin Diversity in Health and Disease2018Inngår i: CELLS, ISSN 2073-4409, Vol. 7, nr 10, artikkel-id 147Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Vimentin is a protein that has been linked to a large variety of pathophysiological conditions, including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also been shown to regulate a wide spectrum of basic cellular functions. In cells, vimentin assembles into a network of filaments that spans the cytoplasm. It can also be found in smaller, non-filamentous forms that can localise both within cells and within the extracellular microenvironment. The vimentin structure can be altered by subunit exchange, cleavage into different sizes, re-annealing, post-translational modifications and interacting proteins. Together with the observation that different domains of vimentin might have evolved under different selection pressures that defined distinct biological functions for different parts of the protein, the many diverse variants of vimentin might be the cause of its functional diversity. A number of review articles have focussed on the biology and medical aspects of intermediate filament proteins without particular commitment to vimentin, and other reviews have focussed on intermediate filaments in an in vitro context. In contrast, the present review focusses almost exclusively on vimentin, and covers both ex vivo and in vivo data from tissue culture and from living organisms, including a summary of the many phenotypes of vimentin knockout animals. Our aim is to provide a comprehensive overview of the current understanding of the many diverse aspects of vimentin, from biochemical, mechanical, cellular, systems biology and medical perspectives.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Brenner, Richard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Zwalinski, L.
    Probing the Quantum Interference between Singly and Doubly Resonant Top-Quark Production in pp Collisions at root s=13 TeV with the ATLAS Detector2018Inngår i: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 121, nr 15, artikkel-id 152002Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This Letter presents a normalized differential cross-section measurement in a fiducial phase-space region where interference effects between top-quark pair production and associated production of a single top quark with a W boson and a b-quark are significant. Events with exactly two leptons (ee, mu mu, or e mu) and two b-tagged jets that satisfy a multiparticle invariant mass requirement are selected from 36.1 fb(-1) of protonproton collision data taken at root s = 13 TeV with the ATLAS detector at the LHC in 2015 and 2016. The results are compared with predictions from simulations using various strategies for the interference. The standard prescriptions for interference modeling are significantly different from each other but are within 2 sigma of the data. State-of-the-art predictions that naturally incorporate interference effects provide the best description of the data in the measured region of phase space most sensitive to these effects. These results provide an important constraint on interference models and will guide future model development and tuning.

  • Hantke, Max Felix
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik. Univ Oxford, Dept Chem, Chem Res Lab, 12 Mansfield Rd, Oxford OX1 3TA, England.
    Bielecki, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik. European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany.
    Kulyk, Olena
    Acad Sci Czech Republ, Inst Phys, ELI Beamlines, Na Slovance 2, CZ-18221 Prague, Czech Republic.
    Westphal, Daniel
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Larsson, Daniel S. D.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Svenda, Martin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Reddy, Hemanth K.N.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Kirian, Richard A.
    Arizona State Univ, Dept Phys, 550 E Tyler Dr, Tempe, AZ 85287 USA.
    Andreasson, Jakob
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik. Acad Sci Czech Republ, Inst Phys, ELI Beamlines, Na Slovance 2, CZ-18221 Prague, Czech Republic;Chalmers Univ Technol, Dept Phys, Condensed Matter Phys, Gothenburg, Sweden.
    Hajdu, Janos
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik. Acad Sci Czech Republ, Inst Phys, ELI Beamlines, Na Slovance 2, CZ-18221 Prague, Czech Republic.
    Maia, Filipe R.N.C.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik. Lawrence Berkeley Natl Lab, NERSC, Berkeley, CA USA.
    Rayleigh-scattering microscopy for tracking and sizing nanoparticles in focused aerosol beams2018Inngår i: IUCrJ, ISSN 0972-6918, E-ISSN 2052-2525, Vol. 5, s. 673-680Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Ultra-bright femtosecond X-ray pulses generated by X-ray free-electron lasers (XFELs) can be used to image high-resolution structures without the need for crystallization. For this approach, aerosol injection has been a successful method to deliver 70-2000 nm particles into the XFEL beam efficiently and at low noise. Improving the technique of aerosol sample delivery and extending it to single proteins necessitates quantitative aerosol diagnostics. Here a lab-based technique is introduced for Rayleigh-scattering microscopy allowing us to track and size aerosolized particles down to 40 nm in diameter as they exit the injector. This technique was used to characterize the 'Uppsala injector', which is a pioneering and frequently used aerosol sample injector for XFEL single-particle imaging. The particle-beam focus, particle velocities, particle density and injection yield were measured at different operating conditions. It is also shown how high particle densities and good injection yields can be reached for large particles (100-500 nm). It is found that with decreasing particle size, particle densities and injection yields deteriorate, indicating the need for different injection strategies to extend XFEL imaging to smaller targets, such as single proteins. This work demonstrates the power of Rayleigh-scattering microscopy for studying focused aerosol beams quantitatively. It lays the foundation for lab-based injector development and online injection diagnostics for XFEL research. In the future, the technique may also find application in other fields that employ focused aerosol beams, such as mass spectrometry, particle deposition, fuel injection and three-dimensional printing techniques.

  • Lilja, Johan
    et al.
    Mittuniversitetet, Fakulteten för naturvetenskap, teknik och medier, Avdelningen för kvalitets- och maskinteknik.
    Abrahamsson, Camilla
    Mittuniversitetet, Fakulteten för naturvetenskap, teknik och medier, Avdelningen för kvalitets- och maskinteknik.
    Palm, Klas
    Uppsala University, Uppsala.
    Hedlund, Christer
    Mittuniversitetet, Fakulteten för naturvetenskap, teknik och medier, Avdelningen för kvalitets- och maskinteknik.
    What Quality Management can Learn from Designers about Being Qualitative2018Inngår i: Proceedings for Pin-C 2018, 2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Quality Management (QM) initiatives and practices generally stress the importance of “focus on customers” and to “base decisions on facts”. However, in Western World QM practice it appears as if facts often become equivalent to numbers - “we need facts” becomes “we need to see it quantified in numbers” and “measuring is knowing”. In sharp contrast, the growing field of Design Thinking (DT) conclude that qualitative approaches are key when it comes to get closer to the citizens or customers, establish new levels of understanding, and thereby inspire new and better solutions. The purpose of this paper is to explore what quality management can learn from designers, and design thinking practice, about using more qualitative approaches for learning and in developing knowledge.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Brenner, Richard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max F.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael U. F.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Zwalinski, L.
    Measurement of the suppression and azimuthal anisotropy of muons from heavy-flavor decays in Pb plus Pb collisions at root s(NN)=2.76 TeV with the ATLAS detector2018Inngår i: Physical Review C: Covering Nuclear Physics, ISSN 2469-9985, E-ISSN 2469-9993, Vol. 98, nr 4, artikkel-id 044905Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    ATLAS measurements of the production of muons from heavy-flavor decays in root s(NN) = 2.76 TeV Pb+Pb collisions and root s = 2.76 TeV pp collisions at the LHC are presented. Integrated luminosities of 0.14 nb(-1) and 570 nb(-1) are used for the Pb+Pb and pp measurements, respectively, which are performed over the muon transverse momentum range 4 < pT < 14 GeV and for five Pb+Pb centrality intervals. Backgrounds arising from in-flight pion and kaon decays, hadronic showers, and misreconstructed muons are statistically removed using a template-fitting procedure. The heavy-flavor muon differential cross sections and per-event yields are measured in pp and Pb+Pb collisions, respectively. The nuclear modification factor R-AA obtained from these is observed to be independent of pT, within uncertainties, and to be less than unity, which indicates suppressed production of heavy-flavor muons in Pb+Pb collisions. For the 10% most central Pb+Pb events, the measured R-AA is approximately 0.35. The azimuthal modulation of the heavy-flavor muon yields is also measured and the associated Fourier coefficients v(n) for n = 2, 3, and 4 are given as a function of pT and centrality. They vary slowly with pT and show a systematic variation with centrality which is characteristic of other anisotropy measurements, such as that observed for inclusive hadrons. The measured R-AA and v(n) values are also compared with theoretical calculations.

  • Nylander, Erik
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Zelleroth, Sofia
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Nyberg, Fred
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Grönbladh, Alfhild
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Hallberg, Mathias
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro2018Inngår i: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 19, nr 11, s. 1-16, artikkel-id ijms-387278Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Evidence to date suggests that opioids such as methadone may be associated with cognitive impairment. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are suggested to be neuroprotective and procognitive in the brain and may therefore counteract these effects. This study aims to explore the protective and restorative effects of GH and IGF-1 in methadone-treated cell cultures. Primary cortical cell cultures were harvested from rat fetuses and grown for seven days in vitro. To examine the protective effects, methadone was co-treated with or without GH or IGF-1 for three consecutive days. To examine the restorative effects, methadone was added for the first 24 h, washed, and later treated with GH or IGF-1 for 48 h. At the end of each experiment, mitochondrial function and membrane integrity were evaluated. The results revealed that GH had protective effects in the membrane integrity assay and that both GH and IGF-1 effectively recovered mitochondrial function and membrane integrity in cells pretreated with methadone. The overall conclusion of the present study is that GH, but not IGF-1, protects primary cortical cells against methadone-induced toxicity, and that both GH and IGF-1 have a restorative effect on cells pretreated with methadone.

  • Passias, Achilleas
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik.
    Prins, Daniel
    Univ Paris Saclay, CNRS, CEA, Inst Phys Theor, F-91191 Gif Sur Yvette, France;Univ Milano Bicocca, Dipartimento Fis, Piazza Sci 3, I-20126 Milan, Italy;INFN, Sez Milano Bicocca, Piazza Sci 3, I-20126 Milan, Italy.
    Tomasiello, Alessandro
    Univ Milano Bicocca, Dipartimento Fis, Piazza Sci 3, I-20126 Milan, Italy;INFN, Sez Milano Bicocca, Piazza Sci 3, I-20126 Milan, Italy.
    A massive class of N=2 AdS(4) IIA solutions2018Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 10, artikkel-id 071Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We initiate a classification of N = 2 supersymmetric AdS4 solutions of (massive) type IIA supergravity. The internal space is locally equipped with either an SU(2) or an identity structure. We focus on the SU(2) structure and determine the conditions it satisfies, dictated by supersymmetry. Imposing as an Ansatz that the internal space is complex, we reduce the problem of finding solutions to a Riccati ODE, which we solve analytically. We obtain in this fashion a large number of new families of solutions, both regular as well as with localized O8-planes and conical Calabi-Yau singularities. We also recover many solutions already discussed in the literature.

  • Boström, Johan
    Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, Lärande, Estetik, Naturvetenskap (LEN). Linköpings universitet, Utbildningsvetenskap.
    Teknik i förskolan – att motverka traditionella könsroller: En aktionsforskningsstudie2018Licentiatavhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    This study shows that developing a gender sensitive technology education in apreschool setting is a very complex and multifaceted task. The preschool, andthe preschool teachers, are expected to help the children develop their technologicalawareness and interest in technology without being limited by traditionalperspectives on gender. However, as research has shown, teachers’ expectationsof children’s behaviour and interest in leisure time activities aregendered and reflect historically developed gendered roles in relation to technology.As this study shows there is a palpable risk of the preschool teacherson one hand focusing on girls and boys as homogenous groups, where a singleindividual gets to represent the group as a whole; and on the other hand, missinggender structures if the mindset is that gender does not factor into theirtreatment of the children at all – that they, automatically in their role astechers, act gender neutral. In this study, the pedagogical conversation wasimportant for the teachers possibility to reflect about their own preconceptions.However, the conversation did not seem to be enough, it was also importantfor the teachers to get to see and reflect on how they actually interactedwith the children in the technological activities. Only then did the teachersactually start to question their preconceptions and began to discuss new waysof acting.

  • Lexell, Jan
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Rehabiliteringsmedicin. Lund Univ, Dept Hlth Sci, Box 157, S-22100 Lund, Sweden; Lulea Univ Technol, Dept Hlth Sci, Lulea, Sweden; Skane Univ Hosp, Dept Neurol & Rehabil Med, Lund, Sweden.
    Jonasson, Stina B.
    Lund Univ, Dept Hlth Sci, Box 157, S-22100 Lund, Sweden;Skane Univ Hosp, Dept Neurol & Rehabil Med, Lund, Sweden.
    Brogardh, Christina
    Lund Univ, Dept Hlth Sci, Box 157, S-22100 Lund, Sweden;Skane Univ Hosp, Dept Neurol & Rehabil Med, Lund, Sweden.
    Psychometric Properties of Three Fatigue Rating Scales in Individuals With Late Effects of Polio2018Inngår i: ANNALS OF REHABILITATION MEDICINE-ARM, ISSN 2234-0645, Vol. 42, nr 5, s. 702-712Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective To evaluate the psychometric properties of the Fatigue Severity Scale (FSS), the Fatigue Impact Scale (FIS), and the Multidimensional Fatigue Inventory (MFI-20) in persons with late effects of polio (LEoP). More specifically, we explored the data completeness, scaling assumptions, targeting, reliability, and convergent validity. Methods A postal survey including FSS, FIS, and MFI-20 was administered to 77 persons with LEoP. Responders received a second survey after 3 weeks to enable test-retest reliability analyses. Results Sixty-one persons (mean age, 68 years; 54% women) responded to the survey (response rate 79%). Data quality of the rating scales was high (with 0%-0.5% missing item responses), the corrected item-total correlations exceeded 0.4 and the scales showed very little floor or ceiling effects (0%-6.6%). All scales had an acceptable reliability (Cronbach's alpha >= 0.95) and test-retest reliability (intraclass correlation coefficient, >= 0.80). The standard error of measurement and the smallest detectable difference were 7%-10% and 20%-28% of the possible scoring range. All three scales were highly correlated (Spearman's correlation coefficient r(s)=0.79-0.80; p<0.001). Conclusion The FSS, FIS, and MFI-20 exhibit sound psychometric properties in terms of data completeness, scaling assumptions, targeting, reliability, and convergent validity, suggesting that these three rating scales can be used to assess fatigue in persons with LEoP. As FSS has fewer items and therefore is less time consuming it may be the preferred scale. However, the choice of scale depends on the research question and the study design.

  • Gainotti, Sabina
    et al.
    Ist Super Sanita, Bioeth Unit, I-00161 Rome, Italy.
    Mascalzoni, Deborah
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Centrum för forsknings- och bioetik.
    Bros-Facer, Virginie
    EURORDIS Rare Dis Europe, F-75014 Paris, France.
    Petrini, Carlo
    Ist Super Sanita, Bioeth Unit, I-00161 Rome, Italy.
    Floridia, Giovanna
    Ist Super Sanita, Bioeth Unit, I-00161 Rome, Italy.
    Roos, Marco
    Leiden Univ, Med Ctr, NL-2333 Leiden, Netherlands.
    Salvatore, Marco
    Ist Super Sanita, Natl Ctr Rare Dis, I-00161 Rome, Italy.
    Taruscio, Domenica
    Ist Super Sanita, Natl Ctr Rare Dis, I-00161 Rome, Italy.
    Meeting Patients' Right to the Correct Diagnosis: Ongoing International Initiatives on Undiagnosed Rare Diseases and Ethical and Social Issues2018Inngår i: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 15, nr 10, artikkel-id 2072Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    The time required to reach a correct diagnosis is a key concern for rare disease (RD) patients. Diagnostic delay can be intolerably long, often described as an odyssey and, for some, a diagnosis may remain frustratingly elusive. The International Rare Disease Research Consortium proposed, as ultimate goal for 2017-2027, to enable all people with a suspected RD to be diagnosed within one year of presentation, if the disorder is known. Subsequently, unsolved cases would enter a globally coordinated diagnostic and research pipeline. In-depth analysis of the genotype through next generation sequencing, together with a standardized in-depth phenotype description and sophisticated high-throughput approaches, have been applied as diagnostic tools to increase the chance of a timely and accurate diagnosis. The success of this approach is evident in the Orphanet database. From 2010 to March 2017 over 600 new RDs and roughly 3600 linked genes have been described and identified. However, combination of -omics and phenotype data, as well as international sharing of this information, has raised ethical concerns. Values to be assessed include not only patient autonomy but also family implications, beneficence, non-maleficence, justice, solidarity and reciprocity, which must be respected and promoted and, at the same time, balanced among each other. In this work we suggest that, to maximize patients' involvement in the search for a diagnosis and identification of new causative genes, undiagnosed patients should have the possibility to: (1) actively participate in the description of their phenotype; (2) choose the level of visibility of their profile in matchmaking databases; (3) express their preferences regarding return of new findings, in particular which level of Variant of Unknown Significance (VUS) significance should be considered relevant to them. The quality of the relationship between individual patients and physicians, and between the patient community and the scientific community, is critically important for optimizing the use of available data and enabling international collaboration in order to provide a diagnosis, and the attached support, to unsolved cases. The contribution of patients to collecting and coding data comprehensively is critical for efficient use of data downstream of data collection.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Brenner, Richard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Zwalinski, L.
    Search for the Higgs boson produced in association with a vector boson and decaying into two spin-zero particles in the H -> aa -> 4b channel in pp collisions at root s=13 TeV with the ATLAS detector2018Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 10, artikkel-id 031Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A search for exotic decays of the Higgs boson into a pair of spin-zero particles, H -> aa, where the a-boson decays into b-quarks promptly or with a mean proper lifetime c tau(a) up to 6 mm and has a mass in the range of 20-60GeV, is presented. The search is performed in events where the Higgs boson is produced in association with a W or Z boson, giving rise to a signature of one or two charged leptons (electrons or muons) and multiple jets from b-quark decays. The analysis is based on the dataset of proton-proton collisions at root s = 13TeV recorded in 2015 and 2016 by the ATLAS detector at the CERN Large Hadron Collider, corresponding to an integrated luminosity of 36: 1 fb(-1). No significant excess of events above the Standard Model background prediction is observed, and 95% confidence-level upper limits are derived for the production cross-sections for pp -> WH, ZH and their combination, times the branching ratio of the decay chain H -> aa -> 4b. For a-bosons which decay promptly, the upper limit on the combination of cross-sections for WH and ZH times the branching ratio of H -> aa -> 4b ranges from 3.0 pb for m(a) = 20 GeV to 1.3 pb for m(a) = 60 GeV, assuming that the ratio of WH to ZH cros-ssections follows the Standard Model prediction. For a-bosons with longer proper lifetimes, the most stringent limits are 1.8 pb and 0.68 pb, respectively, at c tau(a) similar to 0.4 mm.

  • Tedre, Matti
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Competing Claims to Computing as a Discipline (Invited talk)2015Inngår i: 15th Congress of Logic, Methodology and Philosophy of Science, University of Helsinki , 2015Konferansepaper (Fagfellevurdert)