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  • Disputas: 2018-11-30 13:00 Sal B, 9 tr, byggnad 1D, Norrlands Universitetssjukhus, Umeå
    Lampa, Ewa
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Pain and disability in the jaw and neck regions after whiplash trauma: a short- and long-term perspective2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Whiplash trauma, a hyperextension-flexion trauma to the neck that is often related to a car accident, affects tens of thousands in Sweden every year. A significant proportion will develop long-term symptoms including neck pain and dysfunction – this is embraced as Whiplash associated disorders (WAD). Some individuals also develop pain and dysfunction in the orofacial region that is denoted as Temporomandibular disorder (TMD). TMD is common in the population with a prevalence of about 10% but the relation to whiplash trauma is still unclear. The limited number of prospective studies on TMD after whiplash trauma show diverging results, but it has been suggested that TMD develops over time and not in close proximity to the trauma. Prospective studies are needed to determine the course of jaw pain and disability after whiplash trauma.

    The general aim of this thesis was to evaluate the presence and course of pain and disability in the jaw and neck regions at the acute and chronic stages after whiplash trauma.

    This prospective cohort study included at baseline 176 cases with a recent whiplash trauma, and 116 age and gender matched controls without a history of neck trauma that were recruited from the general population. The cases had visited the emergency department at Umeå university hospital, Sweden, with neck pain within 72 hours following a car accident and had been diagnosed with neck distortion by a physician. The cases were examined within one month after the trauma (December 2010 to January 2016) and at a 2-year followup (December 2012 to January 2018). All participants completed questionnaires regarding pain and disability in the jaw and neck regions, physical symptoms (pain and non-pain items), and depression. At baseline, 80 of the cases and 80 of the controls also completed a 5-minute chewing capacity test. At the 2- year follow-up, 119 cases (68%) and 104 controls (90%) were re-examined with the same questionnaires.

    Compared to controls, within one month after a whiplash trauma cases reported significantly more pain in the jaw and neck regions with a positive correlation between the intensity of pain in these regions (Paper I). In the acute stage after trauma, cases, compared to controls, showed a reduced chewing capacity, and this was related to the severity of neck disability (Paper II). For cases, jaw and neck pain correlated positively to each other, to non-specific physical symptoms, and to depression at both the acute (Paper III) and chronic stages (Paper IV). About one third (34%) of the cases reported orofacial pain at baseline, and for a majority of these, the pain persisted at the 2-year follow-up (Paper IV).

    The presence of orofacial pain early after a whiplash trauma indicates involvement of central sensitization and spread of pain between the jaw and neck regions. The positive correlations between pain in the jaw and neck regions, and to psychosocial factors, underline the integration of these regions and the importance of a biopsychosocial perspective. The impaired jaw function shortly after a neck trauma further underlines the close sensorimotor relationship between the trigeminal and cervical regions. The finding that orofacial pain is common shortly after whiplash trauma, and often persists into the chronic stage, indicates that assessment in the acute stage should include both the neck and jaw regions. From this, it follows that multidisciplinary teams that entail both medical professions and dentists specialised in orofacial pain can be beneficial in the early assessment after whiplash trauma.

  • Disputas: 2018-11-30 09:00 E04, R-1, Norrlands Universitetssjukhus, byggnad 6E, Umeå
    Ling, Agnes
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Immune cell infiltration and prognosis in colorectal cancer2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Background: Colorectal cancer (CRC) is globally the second most common form of cancer among women, and third in men. It is also one of the most common causes of cancer-related death in high-income countries. Surgical resection is the basis for curative therapy but still almost half of the patients die from metastatic disease. It is therefore imperative to strive on in the search for more efficient strategies to improve patient survival. The success scores for accurate prediction of patient prognosis remain discouraging and novel markers to identify high-risk patients are called for.

    The tumour immune response has proven critical to prognosis in CRC. A high amount of tumour infiltrating lymphocytes have in studies been found to significantly improve patient outcome. The opposite has been seen in patients with sparsely infiltrated tumours. Findings in this area have driven forth the design of the Immunoscore® system, which may be implemented in clinic as a complement to the TNM staging system. Ongoing research is also focusing on which immune evading mechanisms CRC might deploy in order to progress and metastasize.

    Aim: To study immune cell infiltration in relation to prognosis in CRC. More specifically the aim has been to investigate the prognostic importance of different subsets of immune cells infiltrating the tumour, not only according to quantity but also to intratumoural subsite (tumour invasive front, tumour centre and within the tumour epithelium). The tumour immune response was also evaluated in different molecular subgroups of CRC. Another part of this thesis concerns possible molecular mechanisms involved in tumour immune escape in CRC.

    Methods: CRC cases in the Colorectal Cancer in Umeå Study (CRUMS) were evaluated using immunohistochemistry, gene expression analyses as well as methylation analyses. Cytokine and chemokine expression was evaluated in CRC tumour tissues and one CRC cell line (Caco2) and derivatives using semi-quantitative real-time PCR. Methylation was analysed using methylation-specific pyrosequencing.

    Results: We found high quantities of both cytotoxic T cells (CTLs) as well as of regulatory T cells (Tregs) to associate with a better patient outcome. The infiltration of CTLs within the tumour epithelium provided the strongest prognostic information, whilst Tregs withheld the strongest association to prognosis at the tumour invasive front and tumour centre. We could further show that a high Th1 lymphocyte infiltration was strongly associated with a better prognosis in patients with CRC, independently of intratumoural subsite. Another finding was that the extent of Th1 infiltration and patient outcome differed in different molecular subgroups of CRC. We also found down-regulation of TAP1, a protein involved in antigen presentation by MHC class I, to be significantly associated with low infiltration of various subtypes of immune cells. Down-regulation of TAP1 was also correlated to poor prognosis in patients with early stages of CRC. Furthermore, we found TAP1 expression to be inversely correlated with methylation at sites close to the TAP1 promoter region.

    Conclusion: Tumour infiltrating T lymphocytes have a significant positive impact on prognosis in CRC patients. Different subsets of T lymphocytes vary in their dependency on intratumoural subsite, in to what extent they exert their prognostic influence. We moreover found varying Th1 lymphocyte infiltration rates as well as prognostic impact thereof, in different molecular subgroups of CRC. Our results also show down-regulation of TAP1 to be a mechanism of tumour immune escape in CRC. Further findings suggest methylation of the TAP1 gene to be a putative mechanism for TAP1 down-regulation.

  • Disputas: 2018-11-30 10:00 Hörsal E, Humanisthuset, Umeå
    Lind Pantzare, Anna
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för tillämpad utbildningsvetenskap, Beteendevetenskapliga mätningar (BVM).
    Dimensions of validity: studies of the Swedish national tests in mathematics2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The main purpose for the Swedish national tests was from the beginning to provide exemplary assessments in a subject and support teachers when interpreting the syllabus. Today, their main purpose is to provide an important basis for teachers when grading their students. Although the results from tests do not entirely decides a student’s grade, they are to be taken into special account in the grading process. Given the increasing importance and raise of the stakes, quality issues in terms of validity and reliability is attracting greater attention. The main purpose of this thesis is to examine evidence demonstrating the validity for the Swedish national tests in upper secondary school mathematics and thereby identify potential threats to validity that may affect the interpretations of the test results and lead to invalid conclusions. The validation is made in relation to the purpose that the national tests should support fair and equal assessment and grading. More specifically, the focus was to investigate how differences connected to digital tools, different scorers and the standard setting process affect the results, and also investigate if subscores can be used when interpreting the results. A model visualized as a chain containing links associated with various aspects of validity, ranging from administration and scoring to interpretation and decision-making, is used as a framework for the validation.

    The thesis consists of four empirical studies presented in the form of papers and an introduction with summaries of the papers. Different parts of the validation chain are examined in the studies. The focus of the first study is the administration and impact of using advanced calculators when answering test items. These calculators are able to solve equations algebraically and therefore reduce the risk of a student making mistakes. Since the use of such calculators is allowed but not required and since they are quite expensive, there is an obvious threat to validity since the national tests are supposed to be fair and equal for all test takers. The results show that the advanced calculators were not used to a great extent and it was mainly those students who were high-achieving in mathematics that benefited the most. Therefore the conclusion was that the calculators did not affect the results.

    The second study was an inter-rater reliability study. In Sweden, teachers are responsible for scoring their own students’ national tests, without any training, monitoring or moderation. Therefore it was interesting to investigate the reliability of the scoring since there is a potential risk of bias against one’s own students. The analyses showed that the agreement between different raters, analyzed with percent-agreement and kappa, is rather high but some items have lower agreement. In general, items with several correct answers or items where different solution strategies are available are more difficult to score reliably.

    The cut scores set by a judgmental Angoff standard setting, the method used to define the cut scores for the national tests in mathematics, was in study three compared with a statistical linking procedure using an anchor test design in order to investigate if the cut scores for two test forms were equally demanding. The results indicate that there were no large differences between the test forms. However, one of the test taker groups was rather small which restricts the power of the analysis. The national tests do not include any anchor items and the study highlights the challenges of introducing equating, that is comparing the difficulty of different test forms, on a regular basis.

    In study four, the focus was on subscores and whether there was any value in reporting them in addition to the total score. The syllabus in mathematics has been competence-based since 2011 and the items in the national tests are categorized in relation to these competencies. The test grades are only connected to the total score via the cut scores but the result for each student is consolidated in a result profile based on those competencies. The subscore analysis shows that none of the subscores have added value and the tests would have to be up to four times longer in order to achieve any significant value.

    In conclusion, the studies indicate that several of the potential threats do not appear to be significant and the evidence suggests that the interpretations made and decisions taken have the potential to be valid. However, there is a need for further studies. In particular, there is a need to develop a procedure for equating that can be implemented on a regular basis.

  • Aaboud, M.
    et al.
    Asimakopoulou, Eleni M.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Brenner, Richard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Zwalinski, L.
    Search for flavor-changing neutral currents in top quark decays t -> Hc and t -> Hu in multilepton final states in proton-proton collisions at root s=13 TeV with the ATLAS detector2018Inngår i: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 98, nr 3, artikkel-id 032002Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Flavor-changing neutral currents are not present in the Standard Model at tree level and are suppressed in loop processes by the unitarity of the Cabibbo-Kobayashi-Maskawa matrix; the corresponding rates for top quark decay processes are experimentally unobservable. Extensions of the Standard Model can generate new flavor-changing neutral current processes, leading to signals which, if observed, would be unambiguous evidence of new interactions. A data set conesponding to an integrated luminosity of 36.1 fb(-1) of pp collisions at a center-of-mass energy of root s = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider is used to search for top quarks decaying to up or charm quarks with the emission of a Higgs boson, with subsequent Higgs boson decay to final states with at least one electron or muon. No signal is observed and limits on the branching fractions B(t -> Hc) < 0.16% and B(t -> Hu) < 0.19% at 95% confidence level are obtained (with expected limits of 0.15% in both cases).

  • Yoluk, Özge
    et al.
    KTH, Science for Life Laboratory, SciLifeLab.
    Lindahl, Erik
    KTH, Science for Life Laboratory, SciLifeLab.
    Andersson, Magnus
    Science for Life Laboratory; Theoretical and Computational Biophysics, Department of Theoretical Physics, KTH Royal Institute of Technology, Stockholm, Sweden.
    Conformational Gating Dynamics in the GluCl Anion-Selective Chloride Channel2015Inngår i: ACS Chemical Neuroscience, ISSN 1948-7193, E-ISSN 1948-7193, Vol. 6, nr 8, s. 1459-1467Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Cys-loop receptors are central to propagation of signals in the nervous system. The gating of the membrane-spanning pore is triggered by structural rearrangements in the agonist-binding site, located some so A away from the pore. A sequential conformational change, propagating from the ligand-binding site to the pore, has been proposed to govern gating in all Cys-loop receptors. Here, we identify structural and dynamic components of the conformational gating in the eukaryotic glutamate-gated chloride channel (GluCl) by means of molecular dynamics (MD) simulations with and without the L-glutamate agonist bound. A significant increase in pore opening and accompanying hydration is observed in the presence of glutamate. Potential of mean force calculations reveal that the barrier for ion passage drops from 15 kcal/mol to 5-10 kcal/mol with the agonist bound. This appears to be explained by agonist binding that leads to significant changes in the intersubunit hydrogen-bonding pattern, which induce a slight tilt of the extracellular domain relative to the transmembrane domain in the simulations. This rearrangement is subtle, but correspond to the direction of the quaternary twist observed as a key difference between open and closed X-ray structures. While the full reversible gating is still a much slower process, the observed structural dynamics sheds new light on the early stages of how the agonist influences the extracellular domain, how the extracellular domain interacts with the transmembrane domain, and how changes in the transmembrane domain alter the free energy of ion passage.

  • Kimanius, Dari
    et al.
    Pettersson, Ingrid
    Schluckebier, Gerd
    Lindahl, Erik
    Andersson, Magnus
    Department of Theoretical Physics and Swedish e-Science Research Center, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.
    SAXS-Guided Metadynamics2015Inngår i: Journal of Chemical Theory and Computation, ISSN 1549-9618, E-ISSN 1549-9626, Vol. 11, nr 7, s. 3491-3498Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The small-angle X-ray scattering (SAXS) methodology enables structural characterization of biological macromolecules in solution. However, because SAXS provides low-dimensional information, several potential structural configurations can reproduce the experimental scattering profile, which severely complicates the structural refinement process. Here, we present a bias-exchange metadynamics refinement protocol that incorporates SAXS data as collective variables and therefore tags all possible configurations with their corresponding free energies, which allows identification of a unique structural solution. The method has been implemented in PLUMED and combined with the GROMACS simulation package, and as a proof of principle, we explore the Trp-cage protein folding landscape.

  • Grønberg, Christina
    et al.
    Sitsel, Oleg
    Lindahl, Erik
    Gourdon, Pontus
    Andersson, Magnus
    Theoretical Physics and Swedish e-Science Research Center, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden.
    Membrane Anchoring and Ion-Entry Dynamics in P-type ATPase Copper Transport2016Inngår i: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 111, nr 11, s. 2417-2429Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Cu+-specific P-type ATPase membrane protein transporters regulate cellular copper levels. The lack of crystal structures in Cu+-binding states has limited our understanding of how ion entry and binding are achieved. Here, we characterize the molecular basis of Cu+ entry using molecular-dynamics simulations, structural modeling, and in vitro and in vivo functional assays. Protein structural rearrangements resulting in the exposure of positive charges to bulk solvent rather than to lipid phosphates indicate a direct molecular role of the putative docking platform in Cu+ delivery. Mutational analyses and simulations in the presence and absence of Cu+ predict that the ion-entry path involves two ion-binding sites: one transient Met148-Cys382 site and one intramembranous site formed by trigonal coordination to Cys384, Asn689, and Met717. The results reconcile earlier biochemical and x-ray absorption data and provide a molecular understanding of ion entry in Cu+-transporting P-type ATPases.

  • Banerjee, Souvik
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik. Julius Maximilians Univ Wurzburg, Inst Theoret Phys & Astrophys, D-97074 Wurzburg, Germany..
    Erdmenger, Johanna
    Julius Maximilians Univ Wurzburg, Inst Theoret Phys & Astrophys, D-97074 Wurzburg, Germany.;Max Planck Inst Phys & Astrophys, Werner Heisenberg Inst, Fohringer Ring 6, D-80805 Munich, Germany..
    Sarkar, Debajyoti
    Max Planck Inst Phys & Astrophys, Werner Heisenberg Inst, Fohringer Ring 6, D-80805 Munich, Germany.;Ludwig Maximilians Univ Munchen, Arnold Sommerfeld Ctr, Theresienstr 37, D-80333 Munich, Germany..
    Connecting Fisher information to bulk entanglement in holography2018Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 8, artikkel-id 001Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In the context of relating AdS/CFT to quantum information theory, we propose a holographic dual of Fisher information metric for mixed states in the boundary field theory. This amounts to a holographic measure for the distance between two mixed quantum states. For a spherical subregion in the boundary we show that this is related to a particularly regularized volume enclosed by the Ryu-Takayanagi surface. We further argue that the quantum correction to the proposed Fisher information metric is related to the quantum correction to the boundary entanglement entropy. We discuss consequences of this connection.

  • Janson, Christer
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Lisspers, Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Ställberg, Björn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Johansson, Gunnar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Thuresson, Marcus
    Statisticon AB, Uppsala, Sweden..
    Telg, Gunilla
    AstraZeneca Nord Balt, Sodertalje, Sweden..
    Larsson, Kjell
    Karolinska Inst, Natl Inst Environm Med, Stockholm, Sweden..
    Prevalence, characteristics and management of frequently exacerbating asthma patients: an observational study in Sweden (PACEHR)2018Inngår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52, nr 2, artikkel-id 1701927Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of the study was to investigate the prevalence, management and characteristics of asthma patients with frequent exacerbations. Data from asthma patients (aged >= 18 years) identified in primary care medical records were linked to Swedish national health registries. Exacerbations were defined as hospitalisations, emergency visits and/or collection of oral steroids. Frequent exacerbations were defined as two or more exacerbations per year during the 3-year observation period. Of 18 724 asthma patients, 81.49% had no exacerbations and 6.3% had frequent exacerbations in the year prior to the index date. Frequent exacerbations were observed yearly for 1.8% of the patients. Frequent exacerbators were older, more often females, and had increased eosinophil and neutrophil counts, lower lung function, and more comorbidities than patients without exacerbations. There was a slight increase in asthma medication claims and a slight decrease in physician visits compared with baseline, both in the group with and the group without frequent exacerbations. Patients with frequent exacerbations were characterised by greater age, female predominance, high eosinophil and neutrophil counts, and high prevalence of comorbidities. This study indicates that the Swedish healthcare system lacks efficiency to adjust treatment and management for this patient group. With new treatment options targeting severe asthma available, identification of these patients should be in focus to ensure reduction of exacerbations.

  • Figuero, Andrés
    et al.
    Rodriguez, Alvaro
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för fysik.
    Sande, Jose
    Peña, Enrique
    Rabuñal, Juan R.
    Field measurements of angular motions of a vessel at berth: Inertial device application2018Inngår i: Control Engineering and Applied Informatics, ISSN 1454-8658, Vol. 20, nr 3, s. 79-88Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The study and characterization of the oscillations of a moored vessel has a major importance in port operational efficiency, not only in the design of mooring and anchoring systems, but also in order to prevent the movement of the cargo, minimize ship and dock damage and optimizing the operations which have to take place while the ship is moored.The dynamic behavior of a vessel moored in waves has been mathematically described and interactions between ships and environmental loads such as waves, wind, currents and ice are commonly tested for different docks and mooring systems in scale models. However, field data studies of the behavior moored ships have not been properly addressed so far.This paper proposes a novel application of Inertial Measurement Units to estimate the angular movements (roll, pitch and yaw) of a moored vessel. The proposed technique has been validated in laboratory conditions and the behavior of the ship Urania Mella in the Outer Port of Punta Langosteira (A Coruña, Spain), has been analyzed, obtaining very promising results.

  • Shah, Umer
    et al.
    KTH, Skolan för elektro- och systemteknik (EES), Mikro- och nanosystemteknik.
    Liljeholm, Jessica
    Campion, James
    KTH, Skolan för elektro- och systemteknik (EES), Mikro- och nanosystemteknik.
    Ebefors, Thorbjörn
    Oberhammer, Joachim
    KTH, Skolan för elektro- och systemteknik (EES), Mikro- och nanosystemteknik.
    Low Loss High Linearity RF Interposers Enabled by Through-Glass Vias2018Inngår i: IEEE Microwave and Wireless Components Letters, ISSN 1531-1309, E-ISSN 1558-1764, Vol. 28, nr 11, s. 960-962Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This letter reports on a new low-loss and high linearity3-D wafer-level interposer technology enabled by throughglass vias (TGVs) with an inverted via configuration. Theproposed TGV utilizes a tapered via sidewall profile to achievea void-free conformal metal coverage with lower process timeand fewer fabrication steps than a fully filled conventional TGV.Measurement results for a single 100 μm tall TGV show aninsertion loss of 0.014 dB at 10 GHz and a DC resistanceof 28 mΩ. Finally, this letter reports for the first time onnonlinearity measurements of TGVs. Single-tone measurementsshow that the third harmonic level for a coplanar waveguide(CPW) TGV test structure is only 2 dB higher than a referenceCPW through line without TGVs, indicating an overall excellentlinearity performance.

  • Simons, Greg
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutet för Rysslands- och Eurasienstudier.
    Exploring Interpretations of Zapad-17 Through Baudrillard2018Inngår i: Obieg, ISSN 1732-9795Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • Linden, Christina
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Oftalmiatrik.
    Heijl, Anders
    Jóhannesson, Gauti
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Oftalmiatrik. Umeå universitet, Medicinska fakulteten, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM).
    Aspberg, Johan
    Andersson Geimer, Sabina
    Bengtsson, Boel
    Initial intraocular pressure reduction by mono‐ versus multi‐therapy in patients with open‐angle glaucoma: results from the Glaucoma Intensive Treatment Study2018Inngår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 96, nr 6, s. 567-572Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose: To study newly diagnosed glaucoma patients given mono‐ or multi‐therapy regarding differences in initial intraocular pressure (IOP) reduction, target IOP levels reached and influence of untreated baseline IOP on IOP reduction.

    Methods: Patients newly diagnosed with manifest primary open‐angle glaucoma and included in the Glaucoma Intensive Treatment Study (GITS) were randomized to immediate intensive treatment with any of three different IOP‐lowering substances supplied in two bottles plus 360° laser trabeculoplasty or to conventional stepwise treatment starting with a single‐drug. Intraocular pressure reduction was analysed 1 month after initiation of treatment.

    Results: One hundred eighteen patients (143 eyes) received mono‐therapy and 122 patients (152 eyes) multi‐therapy. Median baseline IOP was 24.0 (min: 9.7, max: 56.0) mmHg in mono‐therapy eyes and 24.0 (min: 12.3, max: 48.5) mmHg in multi‐therapy eyes (p = 0.56). After 1 month in the two groups, respectively, values for median IOP reduction were 6.3 (range: −5.3–31.0) and 11.0 (range: 0.7–34.5) mmHg, and for mean relative decline 26.8 (range: −32.0–55.4) and 46.0 (range: 4.6–81.6) % (p = 0.000). A larger proportion of the multi‐therapy patients reached each target IOP level (p = 0.000). The higher the baseline IOP, the larger the observed pressure reduction, considering both absolute and relative figures. The effect was more pronounced in eyes with multi‐therapy than in those with mono‐therapy (p = 0.000). For every mmHg higher IOP at baseline, the IOP was reduced by an additional 0.56 (mono‐therapy) or 0.84 (multi‐therapy) mmHg.

    Conclusion: Intensive treatment led to considerably greater IOP reduction than mono‐therapy. Among patients with IOP ≥30 mmHg at diagnosis an IOP of <16 was reached in 2/3 of those with multi‐therapy but in none with mono‐therapy. The IOP reduction was highly dependent on the untreated IOP level.

  • Pesquita, Catia
    et al.
    University of Lisbon.
    Ivanova, Valentina
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Lohmann, Steffen
    Fraunhofer IAIS, Germany.
    Lambrix, Patrick
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska högskolan.
    A Framework to Conduct and Report on Empirical User Studies in Semantic Web Contexts2018Inngår i: Knowledge Engineering and Knowledge Management 21st International Conference, EKAW 2018, Nancy, France, November 12-16, 2018, Proceedings / [ed] Catherine Faron Zucker, Chiara Ghidini, Amedeo Napoli, Yannick Toussaint, Cham, 2018, s. 567-583Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Semantic Web technologies are being applied to increasingly diverse areas where user involvement is crucial. While a number of user interfaces for Semantic Web systems have become available in the past years, their evaluation and reporting often still suffer from weaknesses. Empirical evaluations are essential to compare different approaches, demonstrate their benefits and reveal their drawbacks, and thus to facilitate further adoption of Semantic Web technologies. In this paper, we review empirical user studies of user interfaces, visualizations and interaction techniques recently published at relevant Semantic Web venues, assessing both the user studies themselves and their reporting. We then chart the design space of available methods for user studies in Semantic Web contexts. Finally, we propose a framework for their comprehensive reporting, taking into consideration user expertise, experimental setup, task design, experimental procedures and results analysis.

  • Blomstedt, Patric
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Hariz, Marwan
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap. Unit of Functional Neurosurgery, University College of London, Institute of Neurology, London, UK.
    The paper that wrote itself – A ghost story2018Inngår i: Movement Disorders, ISSN 0885-3185, E-ISSN 1531-8257, Vol. 33, nr 9, s. 1509-1510Artikkel i tidsskrift (Fagfellevurdert)
  • Li, Xin
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Molekylär biomimetik.
    Mustila, Henna
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Molekylär biomimetik.
    Magnuson, Ann
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Molekylär biomimetik.
    Stensjö, Karin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Molekylär biomimetik.
    Homologous overexpression of NpDps2 and NpDps5 increases the tolerance for oxidative stress in the multicellular cyanobacterium Nostoc punctiforme2018Inngår i: FEMS Microbiology Letters, ISSN 0378-1097, E-ISSN 1574-6968, Vol. 365, nr 18Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The filamentous cyanobacterium Nostoc punctiforme has several oxidative stress-managing systems, including Dps proteins. Dps proteins belong to the ferritin superfamily and are involved in abiotic stress management in prokaryotes. Previously, we found that one of the five Dps proteins in N. punctiforme, NpDps2, was critical for H2O2 tolerance. Stress induced by high light intensities is aggravated in N. punctiforme strains deficient of either NpDps2, or the bacterioferritin-like NpDps5. Here, we have investigated the capacity of NpDps2 and NpDps5 to enhance stress tolerance by homologous overexpression of these two proteins in N. punctiforme. Both overexpression strains were found to tolerate twice as high concentrations of added H2O2 as the control strain, indicating that overexpression of either NpDps2 or NpDps5 will enhance the capacity for H2O2 tolerance. Under high light intensities, the overexpression of the two NpDps did not enhance the tolerance against general light-induced stress. However, overexpression of the heterocyst-specific NpDps5 in all cells of the filament led to a higher amount of chlorophyll-binding proteins per cell during diazotrophic growth. The OENpDps5 strain also showed an increased tolerance to ammonium-induced oxidative stress. Our results provide information of how Dps proteins may be utilised for engineering of cyanobacteria with enhanced stress tolerance.

  • Stenmark, Magnus
    Naturvårdsverket. Utförare miljöövervakning, Länsstyrelser, lst, Länsstyrelsen Västra Götalands län.
    Miljöövervakning av gaddsteklar med färgskålar och pollinatörsslingor 20102011Rapport (Annet vitenskapelig)
    Abstract [sv]

    Under sommaren 2010 genomfördes miljöövervakning av gaddsteklar och pollinatörer på tiolokaler i Västra Götalands län. Lokalerna var placerade i varsitt ekonomiskt kartblad spriddaöver länet. Kartbladen var slumpade av dem som hade sand eller grus i jordartskarteringensamt minst ett hävdat objekt från ängs‐ och hagmarksinventeringen. För varje kartbladgjordes en bedömning på skärm för att hitta lämpliga undersökningsplatser: småskaligtodlingslandskap, naturliga fodermarker, sand‐ och grusförekomst, närhet till vattendrag ochkuperat landskap var kriterier som i möjligaste mån kombinerades. Förgaddstekelövervakningen användes på varje lokal 3 färgskålar med plexiglasväggar under tvåperioder på sommaren. Det insamlade materialet sorterades och artbestämdes till 135 arterav gaddsteklar. I genomsnitt registrerades 27±15 (±SD) arter av gaddsteklar på varje lokal.Jämfört med inventeringar i andra län pekade resultatet på en låg frekvens av arter medparasitiskt leverne (21 %). Bland vildbina (74 arter) visade sig 25 % av den totalapollensamlande artstocken vara specialiserade att samla pollen från närbesläktade kärlväxter(oligolektiska) – en normal eller låg siffra jämfört med andra studier. Höga parasitfrekvenser idetta sammanhang tyder på hög ekologisk resiliens. Därtill artbestämdes även bifångst avskalbaggar (244 arter), tvåvingar (14 arter), fjärilar (6 arter) ochhalvvingar (54 arter). På varje lokal med omnejd genomfördes enpollinatörsslinga. Denna metod går ut på att registrera kvantitet ochkvalitet av blombesökare på viktiga substratväxter. Enpollinatörsslinga är en 500‐1 000 m lång vandring i likartad miljö därblombesökare och deras beteende på ett exakt antal (500 st)blomställningar registreras. I denna studie utfördespollinatörsslingorna på åkerväddKnautia arvensis och fibblor(Hieracium spp., Pilosella spp. samt Leontodon spp.).Pollinatörsslingorna visade att färre blombesök utförs på deundersökta lokalerna jämfört med liknande biotoper på Öland. Deblombesökande ekologiska grupperna visade sig också skilja sig frånandra delar av Sverige. I Västra Götaland besöktes åkerväddKnautiaarvensisav färre humlor jämfört med andra delar av landet, mendetta kompenserades av att en högre andel tvåvingar med päls(Volucella spp., Eristalis spp., Merodon spp.). Humlor och tvåvingarmed päls är de viktigaste pollinatörerna av åkerväddKnautia arvensisi Sverige. Med färgskålsinventeringen och pollinatörsslingorna kunde12 sällsynta arter (varav 7 rödlistade) identifieras och dessa beskrivsingående. Det sammanvägda resultatet från de två metoderna pekarpå ett generellt mediokert utfall av hotade arter och att det finnsstora ekologiska skillnader mellan de 10 undersökningsområdena.Det svaga utfallet vad gäller hotade arter beror sannolikt till störstadelen på lägre utnyttjandegrad och minskad variation i skötsel avodlingslandskapet.

  • Dufvenberg, Marlene
    et al.
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för fysioterapi. Linköpings universitet, Medicinska fakulteten.
    Adeyemi, Fisayo
    Department of Clinical and Rehabilitation Services, Faculty of Health Science and Medicine, Bond Institute of Health and Sport, Bond University, Robina, Australia.
    Rajendran, Isabelle
    Department of Clinical and Rehabilitation Services, Faculty of Health Science and Medicine, Bond Institute of Health and Sport, Bond University, Robina, Australia.
    Öberg, Birgitta
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för fysioterapi. Linköpings universitet, Medicinska fakulteten.
    Abbott, Allan
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för fysioterapi. Linköpings universitet, Medicinska fakulteten. Department of Clinical and Rehabilitation Services, Faculty of Health Science and Medicine, Bond Institute of Health and Sport, Bond University, Robina, Australia.
    Does postural stability differ between adolescents with idiopathic scoliosis and typically developed?: A systematic literature review and meta-analysis2018Inngår i: Scoliosis and Spinal Disorders, ISSN 2397-1789, Vol. 13, nr 1, artikkel-id 19Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background

    Postural stability deficits have been proposed to influence the onset and progression of adolescent idiopathic scoliosis (AIS). This study aimed to systematically identify, critically evaluate and meta-analyse studies assessing postural stability during unperturbed stance with posturography in AIS compared to typically developed adolescents.

    Methods

    Studies from four electronic databases (PubMed, Scopus, CINAHL, PEDro) were searched and case-control methodological quality assessed using a risk-of-bias assessment tool and a posturography methodological quality checklist. Pooled data regarding centre of pressure (COP) parameters such as sway area, Mediolateral (ML) and Anteroposterior (AP) position and range were compared for AIS and typically developed adolescents using Cohen’s d effect size (ES) and homogeneity estimates.

    Results

    Eighteen studies for quality analysis and 9 of these for meta-analysis were identified from 971 records. Risk-of-bias assessment identified 6 high, 10 moderate and 2 low risk-of-bias studies. The posturography methodological quality checklist identified 4 low, 7 moderate and 7 high-quality studies. Meta-analysis was performed for sway area whereas ML and AP are presented in three different meta-analyses due to divergent measurement units used in the studies: ML position 1 (MLP1), ML position 2 (MLP2) and ML range (MLR); AP position 1 (APP1), AP position 2 (APP2) and AP range (APR). Cohen’s d showed a medium ES difference in sway area 0.65, 95% CI (0.49–0.63), whereas ML showed no (MLP1, MLP2) and large (MLR) ES differences; MLP1 0.15, 95% CI (0.08–0.22); MLP2 0.14, 95% CI (0.08–0.19); and MLR 0.94, 95% CI (0.83–1.04). Cohen’s d for AP showed small ES (APP1) and large ES difference (APP2 and APR); APP1 0.43, 95% CI (0.31–0.54); APP2 0.85, 95% CI (0.72–0.97); and APR 0.98, 95% CI (0.87–1.09). Cochran’s Q and Higgins I2 showed homogeneity between studies.

    Conclusions

    There is moderate quality evidence for decreased postural stability in AIS measured as COP parameters sway area, ML and AP range with a positional shift posteriorly in the sagittal plane. The findings support studying postural stability in early stage AIS and also prospectively identify cause and effect of the curvature as well as effectiveness of postural control interventions in the prevention of scoliosis progression.

  • Kelati, Amleset
    et al.
    KTH, Skolan för elektroteknik och datavetenskap (EECS), Elektronik, Elektronik och inbyggda system. KTH, Skolan för elektroteknik och datavetenskap (EECS), Elektronik, Integrerade komponenter och kretsar. University of Turku, Finland.
    Nigussie, Ethiopia
    University of Turku, Finland.
    Plosila, Juha
    University of Turku, Finland.
    Tenhunen, Hannu
    KTH, Skolan för elektroteknik och datavetenskap (EECS), Elektronik, Integrerade komponenter och kretsar. University of Turku, Finland.
    Biosignal Feature Extraction Techniques for IoT Healthcare Platform2016Inngår i: IEEE Conference on Design and Architectures for Signal and Image Processing (DASIP2016), Rennes, France, 2016Konferansepaper (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    In IoT healthcare platform, a variety of biosignals are acquired from its sensors and appropriate feature extraction techniques are crucial in order to make use of the acquired biosignal data and help the healthcare scientist or bio-engineer to reach at optimal decisions. This work reviews the existing biosignal feature extraction and classification methods for different healthcare applications. Due the enormous amount of different biosignals and since most healthcare applications uses electrocardiogram (ECG), electroencephalogram (EEG), electromyogram (EMG), Electrogastrogram (EGG), we focus the review on feature extractions and classification method for these biosignals. The review also includes a summary of Blood Oxygen Saturation determined by Pulse Oximetry (SpO2), Electrooculography and eye movement (EOG), and Respiration (RSP) signals. Its discussion and analysis focuses on advantages, performance and drawbacks of the techniques.

  • Disputas: 2018-12-06 13:15 Hörsal 2 (Lecture Hall 2), Uppsala
    Kong, Lingshuang
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Företagsekonomiska institutionen.
    The Modern Journey to the West: Exploring Key Factors Influencing Reverse Knowledge Transfer in Emerging-market Multinationals2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    As latecomers to the world economy, emerging-market multinational corporations (EMNCs) often use international expansion as a ‘springboard’ for seeking and accessing advanced knowledge from overseas, particularly from advanced markets, with the goal of offsetting their competitive weaknesses and catching up with their Western counterparts. This behavior is conceptualized as the springboard perspective formulated by Luo and Tung (2007). From this perspective, reverse knowledge transfer (RKT) from subsidiaries to home-country units is a compulsory path to achieve innovation catch-up in EMNCs. This thesis explores reverse knowledge transfer in EMNCs and its key influencing factors, an important and timely phenomenon that has so far received little attention in research.

    Empirical data were collected through a combination of a qualitative case study of one Chinese state-owned multinational and a survey of Chinese multinationals. Results suggest that headquarters’ political relationships in home countries both promote and inhibit RKT practices in EMNCs. Specifically, headquarters’ political relationships are found to enhance the motivation to seek and demand knowledge from subsidiaries. However, at the same time, these political relationships hinder RKT by reducing headquarters’ absorptive capacity, subsidiary willingness and headquarters’ control over subsidiaries, and by increasing the organizational distance between headquarters and subsidiaries. Thus, this study highlights the fact that political relationships can be a liability for cross-border knowledge acquisition. These results contrast with many prior studies, which have tended to view political ties mostly as a source of competitive advantage for EMNCs during internationalization.

    This study also shows how subsidiary willingness to transfer knowledge is restricted by headquarters’ political ties and a large organizational distance between headquarters and subsidiaries in EMNCs. However, the low willingness of subsidiaries to transfer knowledge can be ameliorated if expatriate managers have good-quality relationships with subsidiary local managers. Moreover, the findings suggest that expatriate managers do not engage directly in RKT through their relationship ties. Instead, their relationship ties with local managers can enhance the extent of RKT by stimulating subsidiary willingness. This finding challenges the view of expatriate social ties as channels for transferring knowledge.

    By highlighting the relevance of headquarters’ home-country political relationships and expatriate managers’ relationships in the RKT practices of EMNCs, this thesis enriches the literature on reverse knowledge transfer, on the political relationships of EMNCs and on expatriation. In addition, it contributes to the view of multinationals as a differentiated network. This research also contributes to the understanding of the antecedents and difficulties behind the logic of springboard internationalization and extends the knowledge of intra-organizational agency problems in the context of expatriates and reverse knowledge transfer.

  • Franke, Ulrik
    RISE - Research Institutes of Sweden, ICT, SICS.
    Driftavbrott i samhällsviktiga it-tjänster2018Rapport (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Det moderna samhället är beroende av it-tjänster. Driftavbrott kan leda till allt från kortare elavbrott till brist på livsmedel eller läkemedel. Projektet DRISTIG har under drygt två år studerat driftavbrott i samhällsviktiga it-tjänster. Rapporten redovisar kort några forskningsresultat relaterade till kostnader för avbrott, försäkringar mot avbrott och så kallade Service Level Agreements(SLA).

  • Eriksson, Leif
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH). Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Vårdvetenskap.
    Nga, Nguyen T
    Research Institute for Child Health, Hanoi, Vietnam.
    Hoa, Dinh T Phuong
    Hanoi University of Public Health, Vietnam.
    Duc, Duong M
    Hanoi University of Public Health, Vietnam.
    Bergström, Anna
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH), Internationell barnhälsa och nutrition. Institute for Global Health, University College London, London, UK.
    Wallin, Lars
    School of Education, Health and Social Studies, Dalarna University, Falun, Sweden.
    Målqvist, Mats
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH), Internationell barnhälsa och nutrition.
    Ewald, Uwe
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH), Internationell barnhälsa och nutrition.
    Huy, Tran Q
    Department of Medical Services Administration, Ministry of Health, Nursing office, Hanoi, Vietnam.
    Thuy, Nguyen T
    Vietnam-Sweden Uong Bi General Hospital, Uong Bi, Vietnam.
    Do, Tran Thanh
    National Institute of Nutrition (NIN), Ministry of Health, Hanoi, Vietnam.
    Lien, Pham T L
    Research Institute for Child Health, Hanoi, Vietnam.
    Persson, Lars-Åke
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH), Internationell barnhälsa och nutrition. London School of Hygiene & Tropical Medicine, London, UK.
    Ekholm Selling, Katarina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH), Internationell barnhälsa och nutrition.
    Secular trend, seasonality and effects of a community-based intervention on neonatal mortality: follow-up of a cluster-randomised trial in Quang Ninh province, Vietnam2018Inngår i: Journal of Epidemiology and Community Health, ISSN 0143-005X, E-ISSN 1470-2738, Vol. 72, nr 9, s. 776-782Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background

    Little is know about whether the effects of community engagement interventions for child survival in low-income and middle-income settings are sustained. Seasonal variation and secular trend may blur the data. Neonatal mortality was reduced in a cluster-randomised trial in Vietnam where laywomen facilitated groups composed of local stakeholders employing a problemsolving approach for 3 years. In this analysis, we aim at disentangling the secular trend, the seasonal variation and the effect of the intervention on neonatal mortality during and after the trial.

    Methods

    In Quang Ninh province, 44 communes were allocated to intervention and 46 to control. Births and neonatal deaths were assessed in a baseline survey in 2005, monitored during the trial in 2008–2011 and followed up by a survey in 2014. Time series analyses were performed on monthly neonatal mortality data.

    Results

    There were 30 187 live births and 480 neonatal deaths. The intervention reduced the neonatal mortality from 19.1 to 11.6 per 1000 live births. The reduction was sustained 3 years after the trial. The control areas reached a similar level at the time of follow-up. Time series decomposition analysis revealed a downward trend in the intervention areas during the trial that was not found in the control areas. Neonatal mortality peaked in the hot and wet summers.

    Conclusions

    A community engagement intervention resulted in a lower neonatal mortality rate that was sustained but not further reduced after the end of the trial. When decomposing time series of neonatal mortality, a clear downward trend was demonstrated in intervention but not in control areas.

    Trial registration number: ISRCTN44599712, Postresults.

  • Högström, Stig
    Översiktlig inventering av kärlväxter i naturvårdsområdet Grausne källmyr1989Rapport (Annet vitenskapelig)
    Abstract [sv]

    En översiktlig inventering av vegetaionen genomfördes 1989 på uppdrag av länsstyrelsen. Inventeringen ligger till grund för den skötselplan som inom kort ska upprättas.

  • Miljöfarliga kemikalier och avfall i gotländska industri: en inventering av 186 företag1992Rapport (Annet vitenskapelig)
    Abstract [sv]

    Länsstyrelsen i Gotlands län och Gotlands kommun har genomfört en gemensam inventering av 186 gotländska industriföretag under våren och sommaren 1992. Vid besöken på företagen undersöktes hantering och förbrukning av vissa kemikalier samt hantering och omhändertagande av miljöfarligt avfall.

     

    De kemikalievolymer som förekommer på Gotland är relativt små eftersom kemikalieintensiv industri i egentlig mening saknas på ön. Det finns dock många företag som använder organiska lösningsmedel, totalt förbrukas mer än 130 000 liter per år. En åttondel av lösningsmedelsanvändningen, ca 18 000 liter per år, består av halogenerade kolväten.

    Hanteringen av kemikalier är i allmänhet god, mycket beroende på att kemikalier uppfattas som en kostsam produktionsfaktor.

     

    För industrins avfall är situationen annorlunda. Det betraktas ofta som något helt vid sidan av produktionen.  Många företag ser också sitt miljöfarliga avfall som vilket annat avfall som helst och vidtar därför inte några speciella skyddsåtgärder vid hanteringen. Vissa företag lämnar t ex ut spillolja till privatpersoner. De ser det som ett smidigt och, åtminstone på kort sikt, billigt sätt att bli av med avfallet.

     

                            Avsaknaden av ett mellanlager för miljöfarligt avfall på ön i kombination med ganska små avfallsvolymer totalt sett innebär att avfall lagras onödigt länge på företagen. Det slutliga omhändertagandet av avfallet sker vid olika anläggningar på fastlandet (tex SAKAB). För att de enskilda företagens transportkostnader inte skall bli för stora, åker de speditörer som har tillstånd att transportera miljöfarligt avfall, runt och samlar upp avfallet först när det finns en full billast som kan gå direkt till fastlandet. Detta gör att företagare som ringer och vill bli av med sitt miljöfarliga avfall kan få vänta några månader innan avfallet hämtas.

  • Spoto, F.
    et al.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France.;Univ Lille, Sorbonne Univ, IMCCE, Observ Paris,Univ PSL, 77 Av Denfert Rochereau, F-75014 Paris, France..
    Tanga, P.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Mignard, F.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Berthier, J.
    Univ Lille, Sorbonne Univ, IMCCE, Observ Paris,Univ PSL, 77 Av Denfert Rochereau, F-75014 Paris, France..
    Carry, B.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France.;Univ Lille, Sorbonne Univ, IMCCE, Observ Paris,Univ PSL, 77 Av Denfert Rochereau, F-75014 Paris, France..
    Cellino, A.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Dell'Oro, A.
    INAF Osservatorio Astrofis Arcetri, Largo Enrico Fermi 5, I-50125 Florence, Italy..
    Hestroffer, D.
    Univ Lille, Sorbonne Univ, IMCCE, Observ Paris,Univ PSL, 77 Av Denfert Rochereau, F-75014 Paris, France..
    Muinonen, K.
    Univ Helsinki, Dept Phys, POB 64, 00014 Helsinki, Finland.;Finnish Geospatial Res Inst FGI, Geodeetinrinne 2, Masala 02430, Finland..
    Pauwels, T.
    Royal Observ Belgium, Ringlaan 3, B-1180 Brussels, Belgium..
    Petit, J. -M
    David, P.
    Univ Lille, Sorbonne Univ, IMCCE, Observ Paris,Univ PSL, 77 Av Denfert Rochereau, F-75014 Paris, France..
    De Angeli, F.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Delbo, M.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Frezouls, B.
    CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Galluccio, L.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Granvik, M.
    Univ Helsinki, Dept Phys, POB 64, 00014 Helsinki, Finland.;Lulea Univ Technol, Dept Comp Sci Elect & Space Engn, Box 848, S-98128 Kiruna, Sweden..
    Guiraud, J.
    CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Hernandez, J.
    European Space Astron Ctr ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Ordenovic, C.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Portell, J.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Poujoulet, E.
    AKKA CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-9 Toulouse, France..
    Thuillot, W.
    Univ Lille, Sorbonne Univ, IMCCE, Observ Paris,Univ PSL, 77 Av Denfert Rochereau, F-75014 Paris, France..
    Walmsley, G.
    CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Brown, A. G. A.
    Leiden Univ, Leiden Observ, Niels Bohrweg 2, NL-2333 CA Leiden, Netherlands..
    Vallenari, A.
    INAF Osservatorio astron Padova, Vicolo Osservatorio 5, I-35122 Padua, Italy..
    Prusti, T.
    European Space Res & Technol Ctr ESA ESTEC, Sci Support Off, Directorate Sci, Keplerlaan 1, NL-2201AZ Noordwijk, Netherlands..
    de Bruijne, J. H. J.
    European Space Res & Technol Ctr ESA ESTEC, Sci Support Off, Directorate Sci, Keplerlaan 1, NL-2201AZ Noordwijk, Netherlands..
    Babusiaux, C.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France.;Univ Grenoble Alpes, CNRS, IPAG, F-38000 Grenoble, France..
    Bailer-Jones, C. A. L.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany..
    Biermann, M.
    Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany..
    Evans, D. W.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Eyer, L.
    Univ Geneva, Dept Astron, Chemin Maillettes 51, CH-1290 Versoix, Switzerland..
    Jansen, F.
    European Space Res & Technol Ctr ESA ESTEC, Mission Operat Div, Operat Dept, Directorate Sci, Keplerlaan 1, NL-2201 AZ Noordwijk, 2201, Netherlands..
    Jordi, C.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Klioner, S. A.
    Tech Univ Dresden, Lohrmann Observ, Mommsenstr 13, D-01062 Dresden, Germany..
    Lammers, U.
    European Space Astron Ctr ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Lindegren, L.
    Lund Univ, Dept Astron & Theoret Phys, Lund Observ, Box 43, S-22100 Lund, Sweden..
    Luri, X.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Panem, C.
    CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Pourbaix, D.
    Univ Libre Bruxelles, Inst Astron & dAstrophys, CP 226,Blvd Triomphe, B-1050 Brussels, Belgium.;FRS FNRS, Rue Egmont 5, B-1000 Brussels, Belgium..
    Randich, S.
    INAF Osservatorio Astrofis Arcetri, Largo Enrico Fermi 5, I-50125 Florence, Italy..
    Sartoretti, P.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Siddiqui, H. I.
    Telespazio Vega UK Ltd ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Soubiran, C.
    Univ Bordeaux, CNRS, Lab Astrophys Bordeaux, B18N Allee Geoffroy Saint Hilaire, F-33615 Pessac, France..
    van Leeuwen, F.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Walton, N. A.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Arenou, F.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Bastian, U.
    Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany..
    Cropper, M.
    Univ Coll London, Mullard Space Sci Lab, Dorking RH5 6NT, Surrey, England..
    Drimmel, R.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Katz, D.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Lattanzi, M. G.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Bakker, J.
    European Space Astron Ctr ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Cacciari, C.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Castaneda, J.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Chaoul, L.
    CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Cheek, N.
    Serco Gest Negocios ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Fabricius, C.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Guerra, R.
    European Space Astron Ctr ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Holl, B.
    Univ Geneva, Dept Astron, Chemin Maillettes 51, CH-1290 Versoix, Switzerland..
    Masana, E.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Messineo, R.
    ALTEC Spa, Corso Marche 79, I-10146 Turin, Italy..
    Mowlavi, N.
    Univ Geneva, Dept Astron, Chemin Maillettes 51, CH-1290 Versoix, Switzerland..
    Nienartowicz, K.
    Univ Geneva, Dept Astron, Chemin Ecogia 16, CH-1290 Versoix, Switzerland..
    Panuzzo, P.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Riello, M.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Seabroke, G. M.
    Univ Coll London, Mullard Space Sci Lab, Dorking RH5 6NT, Surrey, England..
    Thevenin, F.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Gracia-Abril, G.
    Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany.;ESAC, Gaia DPAC Project Off, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Comoretto, G.
    Telespazio Vega UK Ltd ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Garcia-Reinaldos, M.
    European Space Astron Ctr ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Teyssier, D.
    Telespazio Vega UK Ltd ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Altmann, M.
    Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany.;Sorbonne Univ, SYRTE, Observ Paris, Univ PSL,CNRS,LNE, 61 Ave Observ, F-75014 Paris, France..
    Andrae, R.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany..
    Audard, M.
    Univ Geneva, Dept Astron, Chemin Maillettes 51, CH-1290 Versoix, Switzerland..
    Bellas-Velidis, I.
    Natl Observ Athens, Athens 15236, Greece..
    Benson, K.
    Univ Coll London, Mullard Space Sci Lab, Dorking RH5 6NT, Surrey, England..
    Blomme, R.
    Royal Observ Belgium, Ringlaan 3, B-1180 Brussels, Belgium..
    Burgess, P.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Busso, G.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Clementini, G.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Clotet, M.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Creevey, O.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Davidson, M.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Midlothian, Scotland..
    De Ridder, J.
    Katholieke Univ Leuven, Inst Sterrenkunde, Celestijnenlaan 200D, B-3001 Leuven, Belgium..
    Delchambre, L.
    Univ Liege, Inst Astrophys & Geophys, 19c Allee 6 Aout, B-4000 Liege, Belgium..
    Ducourant, C.
    Univ Bordeaux, CNRS, Lab Astrophys Bordeaux, B18N Allee Geoffroy Saint Hilaire, F-33615 Pessac, France..
    Fernandez-Hernandez, J.
    ATG Europe ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Fouesneau, M.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany..
    Fremat, Y.
    Royal Observ Belgium, Ringlaan 3, B-1180 Brussels, Belgium..
    Garcia-Torres, M.
    Univ Pablo Olavide, Area Lenguajes & Sistemas Informat, Ctra Utrera Km 1, Seville 41013, Spain..
    Gonzalez-Nunez, J.
    Serco Gest Negocios ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain.;Univ Vigo, ETSE Telecomun, Campus Lagoas Marcosende, Vigo 36310, Galicia, Spain..
    Gonzalez-Vidal, J. J.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Gosset, E.
    FRS FNRS, Rue Egmont 5, B-1000 Brussels, Belgium.;Univ Liege, Inst Astrophys & Geophys, 19c Allee 6 Aout, B-4000 Liege, Belgium..
    Guy, L. P.
    Univ Geneva, Dept Astron, Chemin Ecogia 16, CH-1290 Versoix, Switzerland.;Large Synopt Survey Telescope, 950 N Cherry Ave, Tucson, AZ 85719 USA..
    Halbwachs, J. -L
    Hambly, N. C.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Midlothian, Scotland..
    Harrison, D. L.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England.;Univ Cambridge, Kavli Inst Cosmol, Madingley Rd, Cambride, England..
    Hodgkin, S. T.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Hutton, A.
    Aurora Technol ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Jasniewicz, G.
    Univ Montpellier, Lab Univers & Particules Montpellier, Pl Eugene Bataillon,CC72, F-34095 Montpellier 05, France..
    Jean-Antoine-Piccolo, A.
    CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Jordan, S.
    Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany..
    Korn, Andreas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Observationell astrofysik.
    Krone-Martins, A.
    Univ Lisbon, CENTRA, FCUL, Edif C8, P-1749016 Lisbon, Portugal..
    Lanzafame, A. C.
    Univ Catania, Dipartimento Fis & Astron, Sez Astrofi, Via S Sofia 78, I-95123 Catania, Italy.;INAF Osservatorio Astrofisico Catania, Via S Sofia 78, I-95123 Catania, Italy..
    Lebzelter, T.
    Univ Vienna, Dept Astrophys, Turkenschanzstr 17, A-1180 Vienna, Austria..
    Loeffler, W.
    Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany..
    Manteiga, M.
    Univ A Coruna, CITIC Dept Comp Sci, Campus Elvina S-N, La Coruna 15071, Spain.;Univ A Coruna, CITIC Astron & Astrophys, Campus Elvina S-N, La Coruna 15071, Spain..
    Marrese, P. M.
    INAF Osservatorio Astron Roma, Via Frascati 33, I-00078 Rome, Italy.;Space Sci Data Ctr ASI, Via Politecn SNC, I-00133 Rome, Italy..
    Martin-Fleitas, J. M.
    Aurora Technol ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Moitinho, A.
    Univ Lisbon, CENTRA, FCUL, Edif C8, P-1749016 Lisbon, Portugal..
    Mora, A.
    Aurora Technol ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Osinde, J.
    Isdefe ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Pancino, E.
    INAF Osservatorio Astrofis Arcetri, Largo Enrico Fermi 5, I-50125 Florence, Italy.;Space Sci Data Ctr ASI, Via Politecn SNC, I-00133 Rome, Italy..
    Recio-Blanco, A.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Richards, P. J.
    STFC, Rutherford Appleton Lab, Harwell OX11 0QX, Berks, England..
    Rimoldini, L.
    Univ Geneva, Dept Astron, Chemin Ecogia 16, CH-1290 Versoix, Switzerland..
    Robin, A. C.
    Univ Bourgogne Franche Comte, Inst UTINAM UMR6213, CNRS, OSU THETA Franche Comte Bourgogne, F-25000 Besancon, France..
    Sarro, L. M.
    UNED, Dpto Inteligencia Artificial, C Juan Rosal 6, Madrid 28040, Spain..
    Siopis, C.
    Univ Libre Bruxelles, Inst Astron & dAstrophys, CP 226,Blvd Triomphe, B-1050 Brussels, Belgium..
    Smith, M.
    Univ Coll London, Mullard Space Sci Lab, Dorking RH5 6NT, Surrey, England..
    Sozzetti, A.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Sueveges, M.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany..
    Torra, J.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    van Reeven, W.
    Aurora Technol ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Abbas, U.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Abreu Aramburu, A.
    Elecnor Deimos Space ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Accart, S.
    Thales Serv CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Aerts, C.
    Katholieke Univ Leuven, Inst Sterrenkunde, Celestijnenlaan 200D, B-3001 Leuven, Belgium.;Radboud Univ Nijmegen, Dept Astrophys IMAPP, POB 9010, NL-6500 GL Nijmegen, Netherlands..
    Altavilla, G.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy.;INAF Osservatorio Astron Roma, Via Frascati 33, I-00078 Rome, Italy.;Space Sci Data Ctr ASI, Via Politecn SNC, I-00133 Rome, Italy..
    Alvarez, M. A.
    Univ A Coruna, CITIC Dept Comp Sci, Campus Elvina S-N, La Coruna 15071, Spain..
    Alvarez, R.
    European Space Astron Ctr ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Alves, J.
    Univ Vienna, Dept Astrophys, Turkenschanzstr 17, A-1180 Vienna, Austria..
    Anderson, R. I.
    Univ Geneva, Dept Astron, Chemin Maillettes 51, CH-1290 Versoix, Switzerland.;European Southern Observ, Karl Schwarzschild Str 2, D-85748 Garching, Germany..
    Andrei, A. H.
    Sorbonne Univ, SYRTE, Observ Paris, Univ PSL,CNRS,LNE, 61 Ave Observ, F-75014 Paris, France.;ON MCTI BR, Rua Gal Jose Cristino 77, BR-20921400 Rio De Janeiro, Brazil.;OV UFRJ BR, Ladeira Pedro Antonio 43, BR-20080090 Rio De Janeiro, RJ, Brazil..
    Anglada Varela, E.
    ATG Europe ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Antiche, E.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Antoja, T.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain.;European Space Res & Technol Ctr ESA ESTEC, Sci Support Off, Directorate Sci, Keplerlaan 1, NL-2201AZ Noordwijk, Netherlands..
    Arcay, B.
    Univ A Coruna, CITIC Dept Comp Sci, Campus Elvina S-N, La Coruna 15071, Spain..
    Astraatmadja, T. L.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany.;Carnegie Inst Sci, Dept Terr Magnetism, 5241 Broad Branch Rd NW, Washington, DC 20015 USA..
    Bach, N.
    Aurora Technol ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Baker, S. G.
    Univ Coll London, Mullard Space Sci Lab, Dorking RH5 6NT, Surrey, England..
    Balaguer-Nunez, L.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Balm, P.
    Telespazio Vega UK Ltd ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Barache, C.
    Sorbonne Univ, SYRTE, Observ Paris, Univ PSL,CNRS,LNE, 61 Ave Observ, F-75014 Paris, France..
    Barata, C.
    Univ Lisbon, CENTRA, FCUL, Edif C8, P-1749016 Lisbon, Portugal..
    Barbato, D.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy.;Univ Torino, Dipartimento Fis, Via Pietro Giuria 1, I-10125 Turin, Italy..
    Barblan, F.
    Univ Geneva, Dept Astron, Chemin Maillettes 51, CH-1290 Versoix, Switzerland..
    Barklem, Paul
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Observationell astrofysik.
    Barrado, D.
    ESA ESAC, Ctr Astrobiol CSIC INTA, Dept Astrofis, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Barros, M.
    Univ Lisbon, CENTRA, FCUL, Edif C8, P-1749016 Lisbon, Portugal..
    Barstow, M. A.
    Univ Leicester, Leicester Inst Space & Earth Observat, Univ Rd, Leicester LE1 7RH, Leics, England.;Univ Leicester, Dept Phys & Astron, Univ Rd, Leicester LE1 7RH, Leics, England..
    Bartholome Munoz, S.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Bassilana, J. -L
    Becciani, U.
    INAF Osservatorio Astrofisico Catania, Via S Sofia 78, I-95123 Catania, Italy..
    Bellazzini, M.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Berihuete, A.
    Univ Cadiz, Dept Estadist, Calle Republ Arabe Saharawi S-N, Cadiz 11510, Spain..
    Bertone, S.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy.;Sorbonne Univ, SYRTE, Observ Paris, Univ PSL,CNRS,LNE, 61 Ave Observ, F-75014 Paris, France.;Bern Univ, Astron Inst, Sidlerstr 5, CH-3012 Bern, Switzerland..
    Bianchi, L.
    EURIX SRL, Corso Vittorio Emanuele II 61, I-10128 Turin, Italy..
    Bienayme, O.
    Univ Strasbourg, Observ Astron Strasbourg, CNRS, UMR 7550, 11 Rue Univ, F-67000 Strasbourg, France..
    Blanco-Cuaresma, S.
    Univ Geneva, Dept Astron, Chemin Maillettes 51, CH-1290 Versoix, Switzerland.;Univ Bordeaux, CNRS, Lab Astrophys Bordeaux, B18N Allee Geoffroy Saint Hilaire, F-33615 Pessac, France.;Harvard Smithsonian Ctr Astrophys, 60 Garden St, Cambridge, MA 02138 USA..
    Boch, T.
    Univ Strasbourg, Observ Astron Strasbourg, CNRS, UMR 7550, 11 Rue Univ, F-67000 Strasbourg, France..
    Boeche, C.
    INAF Osservatorio astron Padova, Vicolo Osservatorio 5, I-35122 Padua, Italy..
    Bombrun, A.
    HE Space Operat BV ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Borrachero, R.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Bossini, D.
    INAF Osservatorio astron Padova, Vicolo Osservatorio 5, I-35122 Padua, Italy..
    Bouquillon, S.
    Sorbonne Univ, SYRTE, Observ Paris, Univ PSL,CNRS,LNE, 61 Ave Observ, F-75014 Paris, France..
    Bourda, G.
    Univ Bordeaux, CNRS, Lab Astrophys Bordeaux, B18N Allee Geoffroy Saint Hilaire, F-33615 Pessac, France..
    Bragaglia, A.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Bramante, L.
    ALTEC Spa, Corso Marche 79, I-10146 Turin, Italy..
    Breddels, M. A.
    Univ Groningen, Kapteyn Astron Inst, Landleven 12, NL-9747 AD Groningen, Netherlands..
    Bressan, A.
    SISSA, Via Bonomea 265, I-34136 Trieste, Italy..
    Brouillet, N.
    Univ Bordeaux, CNRS, Lab Astrophys Bordeaux, B18N Allee Geoffroy Saint Hilaire, F-33615 Pessac, France..
    Bruesemeister, T.
    Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany..
    Brugaletta, E.
    INAF Osservatorio Astrofisico Catania, Via S Sofia 78, I-95123 Catania, Italy..
    Bucciarelli, B.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Burlacu, A.
    CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Busonero, D.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Butkevich, A. G.
    Tech Univ Dresden, Lohrmann Observ, Mommsenstr 13, D-01062 Dresden, Germany..
    Buzzi, R.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Caffau, E.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Cancelliere, R.
    Univ Turin, Dept Comp Sci, Corso Svizzera 185, I-10149 Turin, Italy..
    Cannizzaro, G.
    Radboud Univ Nijmegen, Dept Astrophys IMAPP, POB 9010, NL-6500 GL Nijmegen, Netherlands.;SRON Netherlands Inst Space Res, SRON, Sorbonnelaan 2, NL-3584 CA Utrecht, Netherlands..
    Cantat-Gaudin, T.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain.;INAF Osservatorio astron Padova, Vicolo Osservatorio 5, I-35122 Padua, Italy..
    Carballo, R.
    Univ Cantabria, Dpto Matemat Aplicada & Ciencias Computac, Avda Castros S-N, Santander, Spain..
    Carlucci, T.
    Sorbonne Univ, SYRTE, Observ Paris, Univ PSL,CNRS,LNE, 61 Ave Observ, F-75014 Paris, France..
    Carrasco, J. M.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Casamiquela, L.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Castellani, M.
    INAF Osservatorio Astron Roma, Via Frascati 33, I-00078 Rome, Italy..
    Castro-Ginard, A.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Charlot, P.
    Univ Bordeaux, CNRS, Lab Astrophys Bordeaux, B18N Allee Geoffroy Saint Hilaire, F-33615 Pessac, France..
    Chemin, L.
    Univ Antofagasta, Unidad Astron, Avenida Angamos 601, Antofagasta 1270300, Chile..
    Chiavassa, A.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Cocozza, G.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Costigan, G.
    Leiden Univ, Leiden Observ, Niels Bohrweg 2, NL-2333 CA Leiden, Netherlands..
    Cowell, S.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Crifo, F.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Crosta, M.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Crowley, C.
    HE Space Operat BV ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Cuypers, J.
    Royal Observ Belgium, Ringlaan 3, B-1180 Brussels, Belgium..
    Dafonte, C.
    Univ A Coruna, CITIC Dept Comp Sci, Campus Elvina S-N, La Coruna 15071, Spain..
    Damerdji, Y.
    Univ Liege, Inst Astrophys & Geophys, 19c Allee 6 Aout, B-4000 Liege, Belgium.;CRAAG, Route Observ Bp 63, Algiers 16340, Algeria..
    Dapergolas, A.
    Natl Observ Athens, Athens 15236, Greece..
    David, M.
    Univ Antwerp, Onderzoeksgrp Toegepaste Wiskunde, Middelheimlaan 1, B-2020 Antwerp, Belgium..
    de Laverny, P.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    De Luise, F.
    INAF Osservatorio Astron Abruzzo, Via Mentore Maggini, I-64100 Teramo, Italy..
    De March, R.
    ALTEC Spa, Corso Marche 79, I-10146 Turin, Italy..
    de Souza, R.
    Univ Sao Paulo, Inst Astron Geofis & Ciencias Atmosfer, Rua Matao 1226,Cidade Univ, BR-05508900 Sao Paulo, SP, Brazil..
    de Torres, A.
    HE Space Operat BV ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Debosscher, J.
    Katholieke Univ Leuven, Inst Sterrenkunde, Celestijnenlaan 200D, B-3001 Leuven, Belgium..
    del Pozo, E.
    Aurora Technol ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Delgado, A.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Delgado, H. E.
    UNED, Dpto Inteligencia Artificial, C Juan Rosal 6, Madrid 28040, Spain..
    Diakite, S.
    Univ Bourgogne Franche Comte, Inst UTINAM UMR6213, CNRS, OSU THETA Franche Comte Bourgogne, F-25000 Besancon, France..
    Diener, C.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Distefano, E.
    INAF Osservatorio Astrofisico Catania, Via S Sofia 78, I-95123 Catania, Italy..
    Dolding, C.
    Univ Coll London, Mullard Space Sci Lab, Dorking RH5 6NT, Surrey, England..
    Drazinos, P.
    Univ Athens, Dept Astrophys Astron & Mech, Athens 15783, Greece..
    Duran, J.
    Isdefe ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Edvardsson, Bengt
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Observationell astrofysik.
    Enke, H.
    Leibniz Inst Astrophys Potsdam AIP, Sternwarte 16, D-14482 Potsdam, Germany..
    Eriksson, Kjell
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk astrofysik.
    Esquej, P.
    RHEA ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Bontemps, G. Eynard
    CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Fabre, C.
    ATOS CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Fabrizio, M.
    INAF Osservatorio Astron Roma, Via Frascati 33, I-00078 Rome, Italy.;Space Sci Data Ctr ASI, Via Politecn SNC, I-00133 Rome, Italy..
    Faigler, S.
    Tel Aviv Univ, Sch Phys & Astron, IL-6997801 Tel Aviv, Israel..
    Falcao, A. J.
    UNINOVA CTS, Campus FCT UNL, P-2829516 Caparica, Portugal..
    Farras Casas, M.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Federici, L.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Fedorets, G.
    Univ Helsinki, Dept Phys, POB 64, 00014 Helsinki, Finland..
    Fernique, P.
    Univ Strasbourg, Observ Astron Strasbourg, CNRS, UMR 7550, 11 Rue Univ, F-67000 Strasbourg, France..
    Figueras, F.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Filippi, F.
    ALTEC Spa, Corso Marche 79, I-10146 Turin, Italy..
    Findeisen, K.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Fonti, A.
    ALTEC Spa, Corso Marche 79, I-10146 Turin, Italy..
    Fraile, E.
    RHEA ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Fraser, M.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England.;Univ Coll Dublin, Sch Phys, OBrien Ctr Sci North, Dublin 4, Ireland..
    Gai, M.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Galleti, S.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Garabato, D.
    Univ A Coruna, CITIC Dept Comp Sci, Campus Elvina S-N, La Coruna 15071, Spain..
    Garcia-Sedano, F.
    UNED, Dpto Inteligencia Artificial, C Juan Rosal 6, Madrid 28040, Spain..
    Garofalo, A.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy.;Univ Bologna, Dipartimento Fis & Astron, Via Piero Gobetti 93-2, I-40129 Bologna, Italy..
    Garralda, N.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Gavel, Alvin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk astrofysik.
    Gavras, P.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France.;Natl Observ Athens, Athens 15236, Greece.;Univ Athens, Dept Astrophys Astron & Mech, Athens 15783, Greece..
    Gerssen, J.
    Leibniz Inst Astrophys Potsdam AIP, Sternwarte 16, D-14482 Potsdam, Germany..
    Geyer, R.
    Tech Univ Dresden, Lohrmann Observ, Mommsenstr 13, D-01062 Dresden, Germany..
    Giacobbe, P.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Gilmore, G.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Girona, S.
    Ctr Nacl Supercomputac, Barcelona Supercomp Ctr, C Jordi Girona 29,Ed. Nexus 2, Barcelona 08034, Spain..
    Giuffrida, G.
    INAF Osservatorio Astron Roma, Via Frascati 33, I-00078 Rome, Italy.;Space Sci Data Ctr ASI, Via Politecn SNC, I-00133 Rome, Italy..
    Glass, F.
    Univ Geneva, Dept Astron, Chemin Maillettes 51, CH-1290 Versoix, Switzerland..
    Gomes, M.
    Univ Lisbon, CENTRA, FCUL, Edif C8, P-1749016 Lisbon, Portugal..
    Gueguen, A.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France.;Max Planck Inst Extraterr Phys, High Energy Grp, Giessenbachstr, D-85741 Garching, Germany..
    Guerrier, A.
    Thales Serv CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Gutierrez-Sanchez, R.
    Telespazio Vega UK Ltd ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Haigron, R.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Hatzidimitriou, D.
    Natl Observ Athens, Athens 15236, Greece.;Univ Athens, Dept Astrophys Astron & Mech, Athens 15783, Greece..
    Hauser, M.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany.;Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany..
    Haywood, M.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Heiter, Ulrike
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Observationell astrofysik.
    Helmi, A.
    Univ Groningen, Kapteyn Astron Inst, Landleven 12, NL-9747 AD Groningen, Netherlands..
    Heu, J.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Hilger, T.
    Tech Univ Dresden, Lohrmann Observ, Mommsenstr 13, D-01062 Dresden, Germany..
    Hobbs, D.
    Lund Univ, Dept Astron & Theoret Phys, Lund Observ, Box 43, S-22100 Lund, Sweden..
    Hofmann, W.
    Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany..
    Holland, G.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Huckle, H. E.
    Univ Coll London, Mullard Space Sci Lab, Dorking RH5 6NT, Surrey, England..
    Hypki, A.
    Leiden Univ, Leiden Observ, Niels Bohrweg 2, NL-2333 CA Leiden, Netherlands.;Adam Mickiewicz Univ, Astron Observ Inst, Fac Phys, Sloneczna 36, PL-60286 Poznan, Poland..
    Icardi, V.
    ALTEC Spa, Corso Marche 79, I-10146 Turin, Italy..
    Janssen, K.
    Leibniz Inst Astrophys Potsdam AIP, Sternwarte 16, D-14482 Potsdam, Germany..
    de Fombelle, G. Jevardat
    Univ Geneva, Dept Astron, Chemin Ecogia 16, CH-1290 Versoix, Switzerland..
    Jonker, P. G.
    Radboud Univ Nijmegen, Dept Astrophys IMAPP, POB 9010, NL-6500 GL Nijmegen, Netherlands.;SRON Netherlands Inst Space Res, SRON, Sorbonnelaan 2, NL-3584 CA Utrecht, Netherlands..
    Juhasz, A. L.
    Hungarian Acad Sci, Konkoly Observ, Res Ctr Astron & Earth Sci, Konkoly Thege Miklos Ut 15-17, H-1121 Budapest, Hungary.;Eotvos Lorand Univ, Egyetem Ter 1-3, H-1053 Budapest, Hungary..
    Julbe, F.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Karampelas, A.
    Univ Athens, Dept Astrophys Astron & Mech, Athens 15783, Greece.;Amer Community Sch Athens, 129 Aghias Paraskevis Ave & Kazantzaki St, Athens 15234, Greece..
    Kewley, A.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Klar, J.
    Leibniz Inst Astrophys Potsdam AIP, Sternwarte 16, D-14482 Potsdam, Germany..
    Kochoska, A.
    Univ Ljubljana, Fac Math & Phys, Jadranska Ulica 19, Ljubljana 1000, Slovenia.;Villanova Univ, Dept Astrophys & Planetary Sci, 800 E Lancaster Ave, Villanova, PA 19085 USA..
    Kohley, R.
    European Space Astron Ctr ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Kolenberg, K.
    Katholieke Univ Leuven, Inst Sterrenkunde, Celestijnenlaan 200D, B-3001 Leuven, Belgium.;Harvard Smithsonian Ctr Astrophys, 60 Garden St, Cambridge, MA 02138 USA.;Univ Antwerp, Phys Dept, Groenenborgerlaan 171, B-2020 Antwerp, Belgium..
    Kontizas, M.
    Univ Athens, Dept Astrophys Astron & Mech, Athens 15783, Greece..
    Kontizas, E.
    Natl Observ Athens, Athens 15236, Greece..
    Koposov, S. E.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England.;Carnegie Mellon Univ, Dept Phys, McWilliams Ctr Cosmol, 5000 Forbes Ave, Pittsburgh, PA 15213 USA..
    Kordopatis, G.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Kostrzewa-Rutkowska, Z.
    Radboud Univ Nijmegen, Dept Astrophys IMAPP, POB 9010, NL-6500 GL Nijmegen, Netherlands.;SRON Netherlands Inst Space Res, SRON, Sorbonnelaan 2, NL-3584 CA Utrecht, Netherlands..
    Koubsky, P.
    Acad Sci Czech Republ, Astron Inst, Fricova 298, Ondrejov 25165, Czech Republic..
    Lambert, S.
    Sorbonne Univ, SYRTE, Observ Paris, Univ PSL,CNRS,LNE, 61 Ave Observ, F-75014 Paris, France..
    Lanza, A. F.
    INAF Osservatorio Astrofisico Catania, Via S Sofia 78, I-95123 Catania, Italy..
    Lasne, Y.
    Thales Serv CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Lavigne, J. -B
    Le Fustec, Y.
    Telespazio CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Le Poncin-Lafitte, C.
    Sorbonne Univ, SYRTE, Observ Paris, Univ PSL,CNRS,LNE, 61 Ave Observ, F-75014 Paris, France..
    Lebreton, Y.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France.;Univ Rennes 1, Inst Phys Rennes, F-35042 Rennes, France..
    Leccia, S.
    INAF Osservatorio Astron Capodimonte, Via Moiariello 16, I-80131 Naples, Italy..
    Leclerc, N.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Lecoeur-Taibi, I.
    Univ Geneva, Dept Astron, Chemin Ecogia 16, CH-1290 Versoix, Switzerland..
    Lenhardt, H.
    Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany..
    Leroux, F.
    Thales Serv CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Liao, S.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy.;Chinese Acad Sci, Shanghai Astron Observ, 80 Nandan Rd, Shanghai 200030, Peoples R China.;Univ Chinese Acad Sci, Sch Astron & Space Sci, Beijing 100049, Peoples R China..
    Licata, E.
    EURIX SRL, Corso Vittorio Emanuele II 61, I-10128 Turin, Italy..
    Lindstrom, H. E. P.
    Univ Copenhagen, Niels Bohr Inst, Juliane Maries Vej 30, DK-2100 Copenhagen O, Denmark.;DXC Technol, Retortvej 8, DK-2500 Valby, Denmark..
    Lister, T. A.
    Las Cumbres Observ, 6740 Cortona Dr Suite 102, Goleta, CA 93117 USA..
    Livanou, E.
    Univ Athens, Dept Astrophys Astron & Mech, Athens 15783, Greece..
    Lobel, A.
    Royal Observ Belgium, Ringlaan 3, B-1180 Brussels, Belgium..
    Lopez, M.
    ESA ESAC, Ctr Astrobiol CSIC INTA, Dept Astrofis, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Managau, S.
    Thales Serv CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Mann, R. G.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Midlothian, Scotland..
    Mantelet, G.
    Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany..
    Marchal, O.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Marchant, J. M.
    Liverpool John Moores Univ, Astrophys Res Inst, 146 Brownlow Hill, Liverpool L3 5RF, Merseyside, England..
    Marconi, M.
    INAF Osservatorio Astron Capodimonte, Via Moiariello 16, I-80131 Naples, Italy..
    Marinoni, S.
    INAF Osservatorio Astron Roma, Via Frascati 33, I-00078 Rome, Italy.;Space Sci Data Ctr ASI, Via Politecn SNC, I-00133 Rome, Italy..
    Marschalko, G.
    Hungarian Acad Sci, Konkoly Observ, Res Ctr Astron & Earth Sci, Konkoly Thege Miklos Ut 15-17, H-1121 Budapest, Hungary.;Univ Szeged, Baja Observ, Szegedi Ut III-70, H-6500 Baja, Hungary..
    Marshall, D. J.
    CEA Saclay, Lab AIM, IRFU Serv Astrophys, CEA DSM CNRS,Univ Paris Diderot, Bat 709, F-91191 Gif Sur Yvette, France..
    Martino, M.
    ALTEC Spa, Corso Marche 79, I-10146 Turin, Italy..
    Marton, G.
    Hungarian Acad Sci, Konkoly Observ, Res Ctr Astron & Earth Sci, Konkoly Thege Miklos Ut 15-17, H-1121 Budapest, Hungary..
    Mary, N.
    Thales Serv CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Massari, D.
    Univ Groningen, Kapteyn Astron Inst, Landleven 12, NL-9747 AD Groningen, Netherlands..
    Matijevic, G.
    Leibniz Inst Astrophys Potsdam AIP, Sternwarte 16, D-14482 Potsdam, Germany..
    Mazeh, T.
    Tel Aviv Univ, Sch Phys & Astron, IL-6997801 Tel Aviv, Israel..
    McMillan, P. J.
    Lund Univ, Dept Astron & Theoret Phys, Lund Observ, Box 43, S-22100 Lund, Sweden..
    Messina, S.
    INAF Osservatorio Astrofisico Catania, Via S Sofia 78, I-95123 Catania, Italy..
    Michalik, D.
    Lund Univ, Dept Astron & Theoret Phys, Lund Observ, Box 43, S-22100 Lund, Sweden..
    Millar, N. R.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Molina, D.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Molinaro, R.
    INAF Osservatorio Astron Capodimonte, Via Moiariello 16, I-80131 Naples, Italy..
    Molnar, L.
    Hungarian Acad Sci, Konkoly Observ, Res Ctr Astron & Earth Sci, Konkoly Thege Miklos Ut 15-17, H-1121 Budapest, Hungary..
    Montegriffo, P.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Mor, R.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Morbidelli, R.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Morel, T.
    Univ Liege, Inst Astrophys & Geophys, 19c Allee 6 Aout, B-4000 Liege, Belgium..
    Morris, D.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Midlothian, Scotland..
    Mulone, A. F.
    ALTEC Spa, Corso Marche 79, I-10146 Turin, Italy..
    Muraveva, T.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Musella, I.
    INAF Osservatorio Astron Capodimonte, Via Moiariello 16, I-80131 Naples, Italy..
    Nelemans, G.
    Katholieke Univ Leuven, Inst Sterrenkunde, Celestijnenlaan 200D, B-3001 Leuven, Belgium.;Radboud Univ Nijmegen, Dept Astrophys IMAPP, POB 9010, NL-6500 GL Nijmegen, Netherlands..
    Nicastro, L.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Noval, L.
    Thales Serv CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    O'Mullane, W.
    European Space Astron Ctr ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain.;Large Synopt Survey Telescope, 950 N Cherry Ave, Tucson, AZ 85719 USA..
    Ordonez-Blanco, D.
    Univ Geneva, Dept Astron, Chemin Ecogia 16, CH-1290 Versoix, Switzerland..
    Osborne, P.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Pagani, C.
    Univ Leicester, Leicester Inst Space & Earth Observat, Univ Rd, Leicester LE1 7RH, Leics, England.;Univ Leicester, Dept Phys & Astron, Univ Rd, Leicester LE1 7RH, Leics, England..
    Pagano, I.
    INAF Osservatorio Astrofisico Catania, Via S Sofia 78, I-95123 Catania, Italy..
    Pailler, F.
    CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Palacin, H.
    Thales Serv CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Palaversa, L.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England.;Univ Geneva, Dept Astron, Chemin Maillettes 51, CH-1290 Versoix, Switzerland..
    Panahi, A.
    Tel Aviv Univ, Sch Phys & Astron, IL-6997801 Tel Aviv, Israel..
    Pawlak, M.
    Univ Warsaw Observ, Ujazdowskie 4, PL-00478 Warsaw, Poland.;Charles Univ Prague, Inst Theoret Phys, Fac Math & Phys, Prague, Czech Republic..
    Piersimoni, A. M.
    INAF Osservatorio Astron Abruzzo, Via Mentore Maggini, I-64100 Teramo, Italy..
    Pineau, F. -X
    Plachy, E.
    Hungarian Acad Sci, Konkoly Observ, Res Ctr Astron & Earth Sci, Konkoly Thege Miklos Ut 15-17, H-1121 Budapest, Hungary..
    Plum, G.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Poggio, E.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy.;Univ Torino, Dipartimento Fis, Via Pietro Giuria 1, I-10125 Turin, Italy..
    Prsa, A.
    Villanova Univ, Dept Astrophys & Planetary Sci, 800 E Lancaster Ave, Villanova, PA 19085 USA..
    Pulone, L.
    INAF Osservatorio Astron Roma, Via Frascati 33, I-00078 Rome, Italy..
    Racero, E.
    Serco Gest Negocios ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Ragaini, S.
    INAF Osservatorio Astrofis & Sci Spazio Bologna, Via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Rambaux, N.
    Univ Lille, Sorbonne Univ, IMCCE, Observ Paris,Univ PSL, 77 Av Denfert Rochereau, F-75014 Paris, France..
    Ramos-Lerate, M.
    Vitrociset Belgium ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Regibo, S.
    Katholieke Univ Leuven, Inst Sterrenkunde, Celestijnenlaan 200D, B-3001 Leuven, Belgium..
    Reyle, C.
    Univ Bourgogne Franche Comte, Inst UTINAM UMR6213, CNRS, OSU THETA Franche Comte Bourgogne, F-25000 Besancon, France..
    Riclet, F.
    CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Ripepi, V.
    INAF Osservatorio Astron Capodimonte, Via Moiariello 16, I-80131 Naples, Italy..
    Riva, A.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Rivard, A.
    Thales Serv CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Rixon, G.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Roegiers, T.
    HE Space Operat BV ESA ESTEC, Keplerlaan 1, NL-2201 AZ Noordwijk, Netherlands..
    Roelens, M.
    Univ Geneva, Dept Astron, Chemin Maillettes 51, CH-1290 Versoix, Switzerland..
    Romero-Gomez, M.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Rowell, N.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Midlothian, Scotland..
    Royer, F.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Ruiz-Dern, L.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Sadowski, G.
    Univ Libre Bruxelles, Inst Astron & dAstrophys, CP 226,Blvd Triomphe, B-1050 Brussels, Belgium..
    Selles, T. Sagrista
    Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany..
    Sahlmann, J.
    European Space Astron Ctr ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain.;Space Telescope Sci Inst, 3700 San Martin Dr, Baltimore, MD 21218 USA..
    Salgado, J.
    QUASAR Sci Resources ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Salguero, E.
    ATG Europe ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Sanna, N.
    INAF Osservatorio Astrofis Arcetri, Largo Enrico Fermi 5, I-50125 Florence, Italy..
    Santana-Ros, T.
    Adam Mickiewicz Univ, Astron Observ Inst, Fac Phys, Sloneczna 36, PL-60286 Poznan, Poland..
    Sarasso, M.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Savietto, H.
    Fork Res, Rua Cruzado Osberno,Lt 1,9 Esq, Lisbon, Portugal..
    Schultheis, M.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Sciacca, E.
    INAF Osservatorio Astrofisico Catania, Via S Sofia 78, I-95123 Catania, Italy..
    Segol, M.
    APAVE SUDEUROPE SAS CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Segovia, J. C.
    Serco Gest Negocios ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Segransan, D.
    Univ Geneva, Dept Astron, Chemin Maillettes 51, CH-1290 Versoix, Switzerland..
    Shih, I-C
    Siltala, L.
    Univ Helsinki, Dept Phys, POB 64, 00014 Helsinki, Finland.;Nordic Opt Telescope, Rambla Jose Ana Fernandez Perez 7, 38711 38711, Spain..
    Silva, A. F.
    Univ Lisbon, CENTRA, FCUL, Edif C8, P-1749016 Lisbon, Portugal..
    Smart, R. L.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Smith, K. W.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany..
    Solano, E.
    ESA ESAC, Ctr Astrobiol CSIC INTA, Dept Astrofis, Camino Bajo Castillo S-N, Madrid 28692, Spain.;Spanish Virtual Observ, Madrid, Spain..
    Solitro, F.
    ALTEC Spa, Corso Marche 79, I-10146 Turin, Italy..
    Sordo, R.
    INAF Osservatorio astron Padova, Vicolo Osservatorio 5, I-35122 Padua, Italy..
    Soria Nieto, S.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Souchay, J.
    Sorbonne Univ, SYRTE, Observ Paris, Univ PSL,CNRS,LNE, 61 Ave Observ, F-75014 Paris, France..
    Spagna, A.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Stampa, U.
    Heidelberg Univ, Astron Rechen Inst, Zentrum Astron, Monchhofstr 12-14, D-69120 Heidelberg, Germany..
    Steele, I. A.
    Liverpool John Moores Univ, Astrophys Res Inst, 146 Brownlow Hill, Liverpool L3 5RF, Merseyside, England..
    Steidelmueller, H.
    Tech Univ Dresden, Lohrmann Observ, Mommsenstr 13, D-01062 Dresden, Germany..
    Stephenson, C. A.
    Telespazio Vega UK Ltd ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Stoev, H.
    Fdn Galileo Galilei INAF, Rambla Jose Ana Fernandez Perez 7, Brena Baja, Santa Cruz De T, Spain..
    Suess, F. F.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Surdej, J.
    Univ Liege, Inst Astrophys & Geophys, 19c Allee 6 Aout, B-4000 Liege, Belgium..
    Szabados, L.
    Hungarian Acad Sci, Konkoly Observ, Res Ctr Astron & Earth Sci, Konkoly Thege Miklos Ut 15-17, H-1121 Budapest, Hungary..
    Szegedi-Elek, E.
    Hungarian Acad Sci, Konkoly Observ, Res Ctr Astron & Earth Sci, Konkoly Thege Miklos Ut 15-17, H-1121 Budapest, Hungary..
    Tapiador, D.
    INSA ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain.;Univ Complutense Madrid, Dpto Arquitectura Computadores & Automat, Fac Informat, C Prof Jose Garcia Santesmases S-N, Madrid 28040, Spain..
    Taris, F.
    Sorbonne Univ, SYRTE, Observ Paris, Univ PSL,CNRS,LNE, 61 Ave Observ, F-75014 Paris, France..
    Tauran, G.
    Thales Serv CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Taylor, M. B.
    Univ Bristol, HH Wills Phys Lab, Tyndall Ave, Bristol BS8 1TL, Avon, England..
    Teixeira, R.
    Univ Sao Paulo, Inst Astron Geofis & Ciencias Atmosfer, Rua Matao 1226,Cidade Univ, BR-05508900 Sao Paulo, SP, Brazil..
    Terrett, D.
    STFC, Rutherford Appleton Lab, Harwell OX11 0QX, Berks, England..
    Teyssandier, P.
    Sorbonne Univ, SYRTE, Observ Paris, Univ PSL,CNRS,LNE, 61 Ave Observ, F-75014 Paris, France..
    Titarenko, A.
    Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Torra Clotet, F.
    IEEC, Gran Capita 2-4, Barcelona 08034, Spain..
    Turon, C.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Ulla, A.
    Univ Vigo, Appl Phys Dept, Vigo 36310, Spain..
    Utrilla, E.
    Aurora Technol ESA ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Uzzi, S.
    ALTEC Spa, Corso Marche 79, I-10146 Turin, Italy..
    Vaillant, M.
    Thales Serv CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Valentini, G.
    INAF Osservatorio Astron Abruzzo, Via Mentore Maggini, I-64100 Teramo, Italy..
    Valette, V.
    CNES Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    van Elteren, A.
    Leiden Univ, Leiden Observ, Niels Bohrweg 2, NL-2333 CA Leiden, Netherlands..
    Van Hemelryck, E.
    Royal Observ Belgium, Ringlaan 3, B-1180 Brussels, Belgium..
    van Leeuwen, M.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Vaschetto, M.
    ALTEC Spa, Corso Marche 79, I-10146 Turin, Italy..
    Vecchiato, A.
    INAF Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Veljanoski, J.
    Univ Groningen, Kapteyn Astron Inst, Landleven 12, NL-9747 AD Groningen, Netherlands..
    Viala, Y.
    Univ PSL, CNRS, GEPI, Observ Paris, 5 Pl Jules Janssen, F-92190 Meudon, France..
    Vicente, D.
    Ctr Nacl Supercomputac, Barcelona Supercomp Ctr, C Jordi Girona 29,Ed. Nexus 2, Barcelona 08034, Spain..
    Vogt, S.
    HE Space Operat BV ESA ESTEC, Keplerlaan 1, NL-2201 AZ Noordwijk, Netherlands..
    von Essen, C.
    Aarhus Univ, Dept Phys & Astron, Stellar Astrophys Ctr, 120 Ny Munkegade,Bldg 1520, DK-8000 Aarhus C, Denmark..
    Voss, H.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Votruba, V.
    Acad Sci Czech Republ, Astron Inst, Fricova 298, Ondrejov 25165, Czech Republic..
    Voutsinas, S.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Midlothian, Scotland..
    Weiler, M.
    Univ Barcelona, Inst Ciencies Cosmos, IEEC UB, Marti & Franques 1, E-08028 Barcelona, Spain..
    Wertz, O.
    Univ Bonn, Argelander Inst Astron, Hugel 71, D-53121 Bonn, Germany..
    Wevers, T.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England.;Radboud Univ Nijmegen, Dept Astrophys IMAPP, POB 9010, NL-6500 GL Nijmegen, Netherlands..
    Wyrzykowski, L.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England.;Univ Warsaw Observ, Ujazdowskie 4, PL-00478 Warsaw, Poland..
    Yoldas, A.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Zerjal, M.
    Univ Ljubljana, Fac Math & Phys, Jadranska Ulica 19, Ljubljana 1000, Slovenia.;Australian Natl Univ, Res Sch Astron & Astrophys, Canberra, ACT 2611, Australia..
    Ziaeepour, H.
    Univ Bourgogne Franche Comte, Inst UTINAM UMR6213, CNRS, OSU THETA Franche Comte Bourgogne, F-25000 Besancon, France..
    Zorec, J.
    Univ Paris 06, Sorbonne Univ, UPMC, 98 Bis Bd, F-75014 Paris, France.;CNRS, UMR 7095, Inst Astrophys Paris, 98 Bis Bd, F-75014 Paris, France..
    Zschocke, S.
    Tech Univ Dresden, Lohrmann Observ, Mommsenstr 13, D-01062 Dresden, Germany..
    Zucker, S.
    Tel Aviv Univ, Dept Geosci, IL-6997801 Tel Aviv, Israel..
    Zurbach, C.
    Univ Montpellier, Lab Univers & Particules Montpellier, Pl Eugene Bataillon,CC72, F-34095 Montpellier 05, France..
    Zwitter, T.
    Univ Ljubljana, Fac Math & Phys, Jadranska Ulica 19, Ljubljana 1000, Slovenia..
    Gaia Data Release 2: Observations of solar system objects2018Inngår i: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 616, artikkel-id A13Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Context: The Gaia spacecraft of the European Space Agency (ESA) has been securing observations of solar system objects (SSOs) since the beginning of its operations. Data Release 2 (DR2) contains the observations of a selected sample of 14,099 SSOs. These asteroids have been already identified and have been numbered by the Minor Planet Center repository. Positions are provided for each Gaia observation at CCD level. As additional information, complementary to astrometry, the apparent brightness of SSOs in the unfiltered G band is also provided for selected observations.

    Aims: We explain the processing of SSO data, and describe the criteria we used to select the sample published in Gaia DR2. We then explore the data set to assess its quality.

    Methods: To exploit the main data product for the solar system in Gaia DR2, which is the epoch astrometry of asteroids, it is necessary to take into account the unusual properties of the uncertainty, as the position information is nearly one-dimensional. When this aspect is handled appropriately, an orbit fit can be obtained with post-fit residuals that are overall consistent with the a-priori error model that was used to define individual values of the astrometric uncertainty. The role of both random and systematic errors is described. The distribution of residuals allowed us to identify possible contaminants in the data set (such as stars). Photometry in the G band was compared to computed values from reference asteroid shapes and to the flux registered at the corresponding epochs by the red and blue photometers (RP and BP).

    Results: The overall astrometric performance is close to the expectations, with an optimal range of brightness G similar to 12 - 17. In this range, the typical transit-level accuracy is well below 1 mas. For fainter asteroids, the growing photon noise deteriorates the performance. Asteroids brighter than G similar to 12 are affected by a lower performance of the processing of their signals. The dramatic improvement brought by Gaia DR2 astrometry of SSOs is demonstrated by comparisons to the archive data and by preliminary tests on the detection of subtle non-gravitational effects.

  • Klevebrant, Tore
    et al.
    Utförare miljöövervakning, Länsstyrelser, lst, Länsstyrelsen Gotlands län.
    Kulander, Lena
    Utförare miljöövervakning, Länsstyrelser, lst, Länsstyrelsen Gotlands län.
    Äldre grundvattendata: En jämförande studie 1950-tal och 19941994Rapport (Annet vitenskapelig)
    Abstract [sv]

    Rapporten belyser möjligheten att använda ett äldre arkivmaterial som referens till pågående och kommande miljöövervakningsprogram avseende grundvattenkvaliteten i Gotlands län. Arkivmaterialet benämnt "Generalplaneutredning för vattenförsörjning och avlopp, Gotlands län", utgörs av en större grundvattenundersökning utförd under åren 1949-1953.

    I rapporten redogörs för:

    - metod att identifiera samt återbesöka brunnar beskrivna i arkivmaterialet

    - en jämförelse av analysmetoder 1949-53 och 1994

    - en analysresultatjämförelse av prover tagna 1949-53 med prover tagna 1994

    Undersäkningen visar att:

    - det går att återfinna ca 35% av brunnarna

    - analysresultaten från 1949-53 går att jämföra med dagens analyser även om direkta haltjämförelser ej är lämpliga för alla parametrar

    - ingen större kvalitetsförändring kunnat påvisas utifrån de prover som hittills tagits

  • Mauritzon, Åke
    Utförare miljöövervakning, Länsstyrelser, lst, Länsstyrelsen Gotlands län.
    Inventering av miljöfarlig militär verksamhet på Gotland1995Rapport (Annet vitenskapelig)
    Abstract [sv]

    Länsstyrelsen har under våren/sommaren 1994, i samverkan med lokala militära myndigheter, genomfört en inventering av de miljöfarliga fredsverksmheter som bedrivs i försvarsmaktens regi på Gotland. Inventeringen omfattade totalt 41 anläggningar av vilka 32 besöktes.

    Erfarenheterna från anläggningsbesöken visar att mlijötillståndet för den militära verksamheten i stort är gott. Under 1995 kommer i stort sett all militär fredsverksamhet på Gotland att genomgå tillståndsprövning enligt miljöskyddslagen. Önskemål från länsstyrelsens sida på miljöförbättrande åtgärder kommer att preciceras i dessa förestående tillståndsprövningar.

    Diskussioner förs för närvarande med de regionala produktionsledningen för militärområde Gotland om formerna för framtida miljötillsyn för försvarsmaktens anläggningar på ön.

  • Daivadanam, Meena
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för kostvetenskap.
    Kapitel 3. Hälsa: Hur kan fler må bättre?2018Inngår i: Mot en hållbar framtid: Så genomför vi FN:s Agenda 2030 och de globala målen för hållbar utveckling / [ed] Elin Andersdotter Fabre & Joel Ahlgren, Stockholm: Global utmaning , 2018, s. 35-39Kapittel i bok, del av antologi (Annet (populærvitenskap, debatt, mm))
  • Zink, Eren
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för kulturantropologi och etnologi.
    Elvander, Marianne
    Lindberg, Ann
    Järhult, Josef D.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Infektionssjukdomar. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Målqvist, Mats
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH), Internationell barnhälsa och nutrition.
    Boqvist, Sofia
    Bertilsson, Stefan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Limnologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Magnusson, Ulf
    Chandler, Rebecca
    Hur ska vi klara de nya epidemierna?2017Annet (Annet (populærvitenskap, debatt, mm))
  • Zink, Eren
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för kulturantropologi och etnologi.
    Whose Priorities Count?: Empowering Scientific Capacities for Locally Relevant and Sustainable Solutions2017Inngår i: Post Conference Report: Tackling Infectious Disease Threats: Prevent, Detect, Respond with a One Health Approach, Uppsala, Sweden: Uppsala University, 2017, s. 38-41Konferansepaper (Annet vitenskapelig)
  • Zink, Eren
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för kulturantropologi och etnologi.
    Whose Priorities Count?: Empowering Scientific Capacities for Locally Relevant and Sustainable Solutions2017Inngår i: Pre-conference report: Tackling Infectious Disease Threats: Prevent, Detect, Respond with a One Health Approach, Uppsala, Sweden: Uppsala Health Summit , 2017, , s. 6s. 32-37Konferansepaper (Annet vitenskapelig)
  • Zink, Eren
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för kulturantropologi och etnologi.
    Ugandan Scientists, Scandinavian Collaborations, and the Cultural Economy of Science2018Inngår i: Postcolonial Directions in Education, E-ISSN 2304-5388, Vol. 7, nr 1, s. 85-106Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Money and cultural economies of science are imbuedwith multiple meanings for actors involved in internationalscientific research and research training collaborations inUganda. This article uses economic anthropology to explore someof the tensions and misunderstandings that arise from Ugandan-Scandinavian partnerships in science. Using ethnographicexamples drawn from the experiences of Ugandan scientistsand their Scandinavian counterparts, the article describeshow the positions and actions of Ugandan scientists producedifferent, and at times contradictory meanings, for themselves,their kin, local colleagues, and Scandinavian counterparts.Compassion for a grieving sibling, a gift to a charity fundraiser,the extraction of personal savings from an international researchproject, and the strategic construction of a countryside homeare just a few examples of actions and relations that shapeactors’ understandings of Ugandan-Scandinavian scientificcollaborations. The article finds that pre-existing tensions inscientific collaborations resulting from dependency upon foreigndonors for research and research training funding are furtherexacerbated by foreign actors’ partial understandings of themeanings and moralities of scientific work in Uganda. The articleconcludes that greater recognition of the patterns of culturaleconomy that make money and labor in science meaningful arenecessary for mitigating mistrust and misunderstanding acrossSouth-North scientific collaborations.

  • Guzzini, Stefano
    Danish Institute for International Studies.
    Hans J. Morgenthau and the three purposes of power2018Rapport (Annet vitenskapelig)
    Abstract [en]

    Hans Morgenthau's power analysis combines a philosophical, explanatory and practical approach. In his philosophy, power and the will for domination constitutes the nature of politics. In his explanatory approach power, expressed in terms of interest, provides both the aim of foreign policy and the means for its achievements. The practice of power focuses on the ways states(wo)men need to gauge power to avoid miscalculus and its perils. Although filled with insight about the limits of power analysis, like the reduction of power to military affairs or the hubris of the perfect power assessment, Morgenthau's approach is profoundly contradictory. Whereas he needs an explanatory theory of power to support his meta-physical statements, ultimately, the explanatory theory is not independent of it. While his theory should explain the historical record, the somewhat given lessons of history are the defense for his theory (and hence the theory cannot be independently justified). Whereas power needs to be precisely measurable for any statement of its maximisation and balancing, as the explanatory approach requires, his practical approach insists in the sheer impossibility and political danger of believing in such precise measure, since it undermines the realist quest for prudence.

    This analysis will inform the early chapters of a book project on power analysis in International Relations. Morgenthau stands as an example for the awareness that power is used in three different sites at the same time, an awareness often lost in later writers. The different attempts to deal with the tensions and contradictions of using the three sites at the same time will inform the evolution of power analysis in the following chapters.

  • Irrgang, M Eric
    et al.
    University of Virginia.
    Hays, Jennifer M
    University of Virginia.
    Kasson, Peter M.
    University of Virginia.
    gmxapi: a high-level interface for advanced control and extension of molecular dynamics simulations.2018Inngår i: Bioinformatics, ISSN 1367-4803, E-ISSN 1367-4811Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Summary: Molecular dynamics simulations have found use in a wide variety of biomolecular applications, from protein folding kinetics to computational drug design to refinement of molecular structures. Two areas where users and developers frequently need to extend the built-in capabilities of most software packages are implementing custom interactions, for instance biases derived from experimental data, and running ensembles of simulations. We present a Python high-level interface for the popular simulation package GROMACS that 1) allows custom potential functions without modifying the simulation package code, 2) maintains the optimized performance of GROMACS, and 3) presents an abstract interface to building and executing computational graphs that allows transparent low-level optimization of data flow and task placement. Minimal dependencies make this integrated API for the GROMACS simulation engine simple, portable, and maintainable. We demonstrate this API for experimentally-driven refinement of protein conformational ensembles.

    Availability: LGPLv2.1 source and instructions are available at https://github.com/kassonlab/gmxapi.

    Supplementary information: Supplementary data are available at Bioinformatics online.

  • Hays, Jennifer M.
    et al.
    Kieber, Marissa K.
    Li, Jason Z.
    Han, Ji In
    Columbus, Linda
    Kasson, Peter M.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Refinement of highly flexible protein structures using simulation-guided spectroscopy2018Inngår i: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Highly flexible proteins present a special challenge for structure determination because they are multi-structured yet not disordered, so their conformational ensembles are essential for understanding function. Because spectroscopic measurements of multiple conformational populations often provide sparse data, experiment selection is a limiting factor in conformational refinement. We have developed an approach using molecular simulations and information theory to select which experiments best refine conformational ensembles. We test this approach on three flexible proteins. For proteins where a clear mechanistic hypothesis exists, we systematically identify experiments that test this hypothesis. When available data do not yield such mechanistic hypotheses, we identify experiments that significantly outperform structure-guided approaches in conformational refinement. Our approach offers a particular advantage when refining challenging, underdetermined protein conformational ensembles.

  • Fazlhashemi, Mohammad
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen, Tros- och livsåskådningsvetenskap, Systematisk teologi med livsåskådningsforskning.
    Teologiska föreställningar för och emot yttrandefrihet i muslimsk kontext2018Inngår i: Opinionsfrihet och religion / [ed] Bo Lindberg, Stockholm: Kulngl. Vitterhets- historie- och antikvitetsakademien , 2018, 1, s. 45-62Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [sv]

    En tillbakablick i historiens backspegel visar att relationen mellan institutioner och

    makthavare i muslimska länder och det fria ordet har varit mycket komplicerad. Det

    finns otaliga exempel pa hur man har ansträngt sig för att inskränka det fria ordet.

    Under de senaste decennierna har vi sett flera exempel pa protester mot det som klassats

    som blasfemiskt eller upplevts som kränkande av muslimska rättslärda, muslimska

    institutioner och världsliga makthavare i muslimska länder. I en del fall har upplevelserna

    lett till kraftiga protester eller sanktioner mot publiceringsföretag och i andra fall

    har de verbala fördömandena och avstandstagandena övergatt till gatuprotester. Här

    finns ocksa exempel pa blodiga terrorattentat riktade mot publicister som i sin tur lett

    till politiska förvecklingar. Nagra av de mest kända exemplen under den senaste tiden

    är reaktionerna mot den brittiske författaren Salman Rushdies bok

    Satansverserna i

    slutet av 1980-talet, protesterna mot den danska tidningen

    Gyllandspostens teckningar

    av islams profet Muhammed under 00-talet och senast Muhammedteckningarna i

    massakern pa redaktionen pa den franska satirtidningen

    Charlie Hebdo.

    Bilden är emellertid inte entydig. Vid närmare betraktande finner vi att det parallellt

    med inskränkningarna för yttrandefriheten har funnits exempel pa religiösa företrädare

    och makthavare som värnade om det fria ordet. Sadana exempel finns bade under

    islams historia och under var samtid. Fragan är hur detta stöd har motiverats. Vilka

    teologiska argument har det fria ordets försvarare använt i sin argumentering? Hur ska

    man första/förklara de nutida muslimska tänkarnas stöd för yttrande- och tryckfrihet?

    En annan och kanske lika viktig fraga är vad som är viktigast i detta sammanhang,

    religiösa och teologiska föreställningar eller religiösa aktörer. Denna frageställning ansluter

    till den klassiska fragan: ”Vad kom först, hönan eller ägget?” Spelar de religiösa

    föreställningarna i sig en roll för stödet at det fria ordet och har idétraditionerna nagon

    egen verkan, eller är det aktörerna och företrädarna som ger dem effekt?

  • Karlsson, Chatarina
    Utförare miljöövervakning, Länsstyrelser, lst, Länsstyrelsen Örebro län. Pelagia Nature & Environment AB.
    Växtplankton i fyra sjöar i Örebro län 2018: Statusbedömning av miljötillståndet2018Rapport (Annet vitenskapelig)
    Abstract [sv]

    Länsstyrelsen i Örebro län har 2018 undersökt växtplankton från fyra sjöar.

    Den sammanvägda statusen baserat enbart på år 2018 gav Hög status för Lilla Grängen (Hällefors kommun) och Saxen (Hällefors/Filipstads kommun), medan Storsjön (Askersunds kommun) och Östersjön (Asker­sunds/Laxå kommun) uppvisade God status. Den framtagna statusen överensstämmer i stort med den expertbedömning som utförts av Pelagia Nature & Environment AB. Reservation görs med hänseende till blom­ningen av Gonyostomum semen som noterades i Storsjön och som kan förändra förhållandena i en sjö.

  • Disputas: 2018-12-14 13:00 Berzeliussalen, Linköping
    Vavruch, Ludvig
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Ortopedkliniken i Linköping.
    Adolescent Idiopathic Scoliosis: A Deformity in Three Dimensions2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Scoliosis is a complex three-dimensional deformity of the spine. Even though it has been known for centuries, treatment of the deformity has focused on correcting only in the frontal plane. In the last decades, the need for three-dimensional assessment regarding scoliosis has been highlighted to better understand the cause and the principles of treating scoliosis. The overall aim of this dissertation is to provide knowledge to assess scoliosis as a three-dimensional problem.

    The severity of scoliosis is measured with the Cobb angle from standing radiographs. Computed tomography (CT) examinations are used throughout this thesis. The first paper investigates the difference in Cobb angle measured from standing radiographs and supine CT examinations. The standing radiographs had larger Cobb angles with a mean difference of 11° and a linear correlation between the two examinations from 128 consecutive patients with adolescent idiopathic scoliosis (AIS) planned for surgery.

    The second paper compares the axial shape of vertebrae in 20 patients with AIS with a reference group. Clear asymmetry was observed in all vertebrae – superior and inferior end vertebrae as well as the apical vertebra – compared with corresponding vertebrae among the reference group. The asymmetry was most pronounced in the apical vertebra. A novel parameter, frontal vertebral body rotation (FVBR), was introduced to describe the internal rotation of the vertebrae in the axial plane.

    Pelvic incidence (PI) is a measurement of the position of the sacrum in relation to the femoral heads. This is relevant in scoliosis because PI determines the pelvic configuration acting as a foundation to the spine. PI has traditionally been measured from standing radiographs. The third study investigates PI three-dimensionally, based on low-dose CT examinations, in 37 patients with Lenke type 1 or 5 curves compared with a reference group. A significantly higher PI was observed in patients with Lenke type 5 curves compared with the reference group and patients with Lenke type 1 curves.

    Severe AIS is treated with corrective surgery. Two approaches are available: the predominant posterior approach and the anterior approach. In the fourth paper, these two approaches are evaluated with regard to three-dimensional correction, how well the correction is maintained over a 2-year follow-up and patient-reported outcome measures. Twenty-seven patients treated with the posterior approach and 26 patients treated with the anterior approach, all with Lenke type 1 curves, were included. Fewer vertebrae were fused in the anterior group, but the posterior group had a better correction of the deformity in the frontal plane. No difference was observed regarding three-dimensional correction and patient-reported outcome measures.

    AIS is truly a complex three-dimensional deformity. More research is needed to fully comprehend the complexity of the scoliotic spine.

  • Kulander, Lena
    et al.
    Utförare miljöövervakning, Länsstyrelser, lst, Länsstyrelsen Gotlands län.
    Andersson, Sven
    Utförare miljöövervakning, Länsstyrelser, lst, Länsstyrelsen Gotlands län.
    Nyberg, Kalle
    Utförare miljöövervakning, Länsstyrelser, lst, Länsstyrelsen Gotlands län.
    Kvaliteten hos grundvattnet i 30 gotländska vattentäkter 1989-19941995Rapport (Annet vitenskapelig)
    Abstract [sv]

    Provtagningsprogrammet har haft som primärt syfte att  undersökajordbrukets påverkan på grundvattnet. Återkommande provtagning och analys av grundvattnet har genomförts

    vid 30 platser bestående av enskilda och kommunala vattentäkter och naturliga källor under perioden 1989-1994. Vattenprover har analyserats m a p kemisk  sammansättning,  förekomst av mikroorganismer och förekomst av bekämpningsmedelsrester.

     

    För att avgöra påverkansgrad måste en jämförelse göras mot vad som kan betraktas som vattnets "naturliga" sammansättning i området. Detta innebär vissa svårigheter då många faktorer har betydelse för sammansättningen och stora lokala och regionala variationer kan förekomma. För ändamålet valdes ett antal referensstationer utanför jordbruksmark.

     

    Det ska observeras att den i rapporten diskuterade vattenkvaliteten vid kommunala vatten­ täkter gäller analyser av det obehandlade s k råvattnet och inte det renvatten som går ut i vattenledningsnätet. Råvatten har analyserats eftersom syftet varit att undersöka eventuell påverkan av själva grundvattenresursen snarare än att utvärdera det konsumerade dricks­ vattnets kvalitet. Ca 65% av invånarna i länet har kommunalt vatten som genomgår regel­ bunden kontroll och viss behandling. Det i undersökningen analyserade vattnet skiljer sig från det normalt konsumerade även genom att ledningsnätet alltid genomspolats före provtagning. Den tekniska standarden på enskilda vattentäkter varierar också i allmänhet mer än hos de som utvalts för denna undersökning.

     

    Merparten av provtagna områden utanför jordbruksmark hade opåverkat grundvatten. Att förhöjda nitrat- och bakteriehalter ändå uppmättes vid två referensstationer understryker att grundvattnet har stor sårbarhet, speciellt i bergakviferer med tunna }ordlager och grova jordarter och i ytliga grusakviferer.

     

    Undersökningen klarlägger att förhöjda närsaltshalter kanpåvisas i brunnar på jordbruksmårk. Resultaten tyder dock inte på att halterna generellt är alarmerande höga. Provtagna grävda brunnar var starkt påverkade av kväve, fosfat och bakterier. I drygt hälften av provtagna borrade brunnar på jordbruksmark påvisades förekomst av nitrat och i drygt ¼ var halterna anmärkningsvärt höga.

     

    Av de 30 provtagningsstationerna var 9 stationer helt opåverkade av bakterier. Ungefär hälften av referensstationerna och ¾ av stationerna på jordbruks mark var vid något tillfälle bakteriepåverkade.

     

    Resultaten från provtagningarna tyder inte på att rester av bekämpningsmedel i grund­ vatten kan betraktas som ett generellt problem.

     

    Merparten av de borrade brunnarna uppvisade de högsta nitrathalterna under februari  och de lägsta halterna i oktober. Bakteriepåverkan var utpräglat årstidsberoende med anmärk­ ningsvärt höga bakteriehalter i 20-26% av proven under kvartål 3 och 4 jämfört med 13% under kvartal 1.

  • Brink, Rob C.
    et al.
    Department of Orthopaedic Surgery, G05.228, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands..
    Vavruch, Ludvig
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
    Schlösser, Tom P. C.
    Department of Orthopaedic Surgery, G05.228, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands..
    Abul-Kasim, Kasim
    Division of Neuroradiology, Diagnostic Centre for Imaging and Functional Medicine, Faculty of Medicine, Lund University, Skåne University Hospital, Malmö, Sweden..
    Ohlin, Acke
    Department of Orthopaedic Surgery, Faculty of Medicine, Lund University, Skåne University Hospital, Malmö, Sweden..
    Tropp, Hans
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Ortopedkliniken i Linköping.
    Castelein, René M.
    Department of Orthopaedic Surgery, G05.228, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands. r.m.castelein@umcutrecht.nl..
    Vrtovec, Tomaž
    Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia..
    Three-dimensional pelvic incidence is much higher in (thoraco)lumbar scoliosis than in controls2018Inngår i: European spine journal, ISSN 0940-6719, E-ISSN 1432-0932Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose

    The pelvic incidence (PI) is used to describe the sagittal spino-pelvic alignment. In previous studies, radiographs were used, leading to less accuracy in establishing the three-dimensional (3D) spino-pelvic parameters. The purpose of this study is to analyze the differences in the 3D sagittal spino-pelvic alignment in adolescent idiopathic scoliosis (AIS) subjects and non-scoliotic controls.

    Methods

    Thirty-seven female AIS patients that underwent preoperative supine low-dose computed tomography imaging of the spine, hips and pelvis as part of their general workup were included and compared to 44 non-scoliotic age-matched female controls. A previously validated computerized method was used to measure the PI in 3D, as the angle between the line orthogonal to the inclination of the sacral endplate and the line connecting the center of the sacral endplate with the hip axis.

    Results

    The PI was on average 46.8° ± 12.4° in AIS patients and 41.3° ± 11.4° in controls (p = 0.025), with a higher PI in Lenke type 5 curves (50.6° ± 16.2°) as compared to controls (p = 0.042), whereas the Lenke type 1 curves (45.9° ± 12.2°) did not differ from controls (p = 0.141).

    Conclusion

    Lenke type 5 curves show a significantly higher PI than controls, whereas the Lenke type 1 curves did not differ from controls. This suggests a role of pelvic morphology and spino-pelvic alignment in the pathogenesis of idiopathic scoliosis. Further longitudinal studies should explore the exact role of the PI in the initiation and progression of different AIS types.

  • Pettersson, Andreas
    et al.
    Utförare miljöövervakning, Länsstyrelser, lst, Länsstyrelsen Gotlands län.
    Raymond, Caroline
    Stockhoms universitet.
    Svensson, Ola
    Stockholms universitet.
    Gunnarsson, Jonas
    Stockholms universitet.
    Miljööverakning av mjukbottenfauna i Gotlands kustområden: Klintehamn, Slite och Fårösund, samt När-Östergarn2018Rapport (Annet vitenskapelig)
    Abstract [sv]

    Denna rapport redovisar resultaten av 2016-2017 års undersökning av mjukbottenfaunan inom det nya nationellt-regionalt samordnade programmet i Gotlands län. Programmet undersöker långsiktiga och storskaliga förändringar av referensområden i Egentliga Östersjön som en effekt av främst övergödning och syrebrist i bottenvattnet samt följer den biologiska mångfalden. I det nya programmet (sedan 2016) provtas dels det nationella klustret NAT När öster om Gotland, dels tre regionala kluster (Slite, Klintehamn och Fårösund). I det nya stationsnätet har fem stationer från det tidigare klustret REG När ersatt fem tidigare provtagna stationer i klustret NAT När. Alla stationerna är provtagna sedan 2007, men data från NAT När i det nya programmet är pga denna förändring av stationer inte jämförbar med dem i tidigare rapporter. De regionala klustren har tidigare undersökts under 2006, 2008, 2011 och 2014. För dessa områden utgörs den största förändringen i det nya programmet av en högre provtagningsfrekvens och att sex stationer provtas i varje kluster istället för tidigare fem

    .

    Det primära syftet med undersökningen är att enligt EU:s vattendirektiv bedöma miljöstatus. Detta sker med hjälp av Benthic Quality Index (BQI) som baseras på makrofaunans sammansättning. De årligen besökta stationerna som ingår i det nya klustret NAT När har uppvisat

    god status årligen sedan 2007. Även områdena utanför Slite och Klintehamn har uppvisat god status vid alla undersökningstillfällen. I området Fårösund däremot har status varierat; måttlig 2006, god 2008, otillfredsställande 2011, god 2014 samt slutligen åter måttlig status 2017.

  • von Wright, Moira
    Örebro universitet.
    Recension av Lena Fritzéns doktorsavhandling Den pedagogiska praktikens janusansikte.1999Inngår i: Utbildning och Demokrati, ISSN 1102-6472, E-ISSN 2001-7316, Vol. 8, nr 2, s. 129-136Artikkel, omtale (Annet vitenskapelig)
  • Alakpa, Enateri V.
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB).
    Saeed, Anwer
    Chung, Peter
    Riehle, Mathis O.
    Gadegaard, Nikolaj
    Dalby, Matthew J.
    Cusack, Maggie
    The Prismatic Topography of Pinctada maxima Shell Retains Stem Cell Multipotency and Plasticity In Vitro2018Inngår i: Advanced Biosystems, ISSN 2366-7478, Vol. 2, nr 6, artikkel-id 1800012Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The shell of the bivalve mollusc Pinctada maxima is composed of the calcium carbonate polymorphs calcite and aragonite (nacre). Mother-of-pearl, or nacre, induces vertebrate cells to undergo osteogenesis and has good osteointegrative qualities in vivo. The calcite counterpart, however, is less researched in terms of the response of vertebrate cells. This study shows that isolation of calcite surface topography from the inherent chemistry allows viable long-term culture of bone marrow derived mesenchymal stem cells (MSCs). Self-renewal is evident from the increased gene expression of the self-renewal markers CD63, CD166, and CD271 indicating that cells cultured on the calcite topography maintain their stem cell phenotype. MSCs also retain their multipotency and can undergo successful differentiation into osteoblasts and adipocytes. When directed to adipogenesis, MSCs cultured on prism replicas are more amenable to differentiation than MSCs cultured on tissue culture polystyrene indicating a higher degree of plasticity in MSCs growing on calcite P. maxima prismatic topography. The study highlights the potential of the calcite topography of P. maxima as a biomimetic design for supporting expansion of MSC populations in vitro, which is of fundamental importance if it meets the demands for autologous MSCs for therapeutic use.

  • Larsson, Kjell
    Sjöfartsskolan, Linnéuniversitet.
    Fartygstrafik i och nära skyddade och känsliga havsområden runt Gotland och Öland2018Rapport (Annet vitenskapelig)
    Abstract [sv]

    Den internationella fartygstrafiken i Östersjön och inte minst i havsområdet runt Gotland ochÖland är mycket intensiv och förväntas öka i omfattning under kommande år. Sjöfartenbehöver tillgång till utrymme på havet i form av ändamålsenliga och säkra fartygsrutter.Intensiv fartygstrafik medför dock påverkan på havsmiljön på grund av driftsrelateradeutsläpp till luft och vatten. Intensiv trafik medför även risker för kollisioner, grundstötningaroch andra fartygsolyckor som kan ge upphov till mycket stor miljöpåverkan.Sverige har liksom de flesta av världens länder i enlighet med internationella konventioner ettuppdrag att skydda minst 10 % av havet. Införandet av marina reservat och nationalparkerinnanför svensk territorialgräns, och av marina Natura 2000-områden innanför territorialgränsoch i svensk ekonomisk zon enligt nationell lagstiftning och EU-direktiv, är ett led iuppdraget. Andra internationella konventioner reglerar vilka åtgärder som kan vidtas för attstyra fartygstrafik eller för att rekommendera sjöfarten att undvika vissa havsområden.Havsplanering är ett verktyg för att styra det rumsliga nyttjandet av havet och för att reducerakonflikter mellan olika samhällsintressen, t.ex. mellan behovet av sjöfart och behovet av attskydda havsmiljön och marin biologisk mångfald. För att på ett effektivt sätt kunnahavsplanera och förbättra och utöka skyddet av värdefulla marina områden krävs kunskap omden påverkan som mänskliga aktiviteter, bland annat sjöfart, har på områdena. Ett första stegär att identifiera de havsområden där fartygstrafiken är mycket intensiv, där fartyg passerargenom eller nära särskilt känsliga områden, där fartyg med särskilt farlig last passerar ellerdär många fartyg ankrar under längre perioder.Syftet med rapporten är att sammanställa information om fartygstrafik i och nära skyddadeoch känsliga havsområden runt Gotland och Öland. I rapporten beskrivs först hur analyser avfartygstrafik kan genomföras med hjälp av lagrade AIS-data. Därefter beskrivs fartygstrafikeni centrala Östersjön och i särskilda fokusområden runt Gotland och Öland. Avslutningsvisdiskuteras risker med fartygstrafik i känsliga havsområden och hur konflikter mellansjöfartens behov och marint områdesskydd kan reduceras. Rapporten har producerats inomprojektet ”Marina skyddsvärden runt Gotland och Öland ” som letts av Länsstyrelsen iGotlands län.

  • Bergman, Emma Ahlen
    et al.
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden..
    Hartana, Ciputra Adijaya
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden..
    Johansson, Markus
    Sundsvall Hosp, Dept Urol, Sundsvall, Sweden.;Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden..
    Linton, Ludvig B.
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden..
    Berglund, Sofia
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden..
    Hyllienmark, Martin
    TLA Targeted Immunotherapies AB, Stockholm, Sweden..
    Lundgren, Christian
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden..
    Holmström, Benny
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Urologkirurgi.
    Palmqvist, Karin
    Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden.;Ostersund Cty Hosp, Urol Sect, Dept Surg, Ostersund, Sweden..
    Hansson, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Gävleborg.
    Alamdari, Farhood
    Vastmanland Hosp, Dept Urol, Vasteras, Sweden..
    Huge, Ylva
    Linkoping Univ, Div Urol, Dept Clin & Expt Med, Linkoping, Sweden..
    Aljabery, Firas
    Linkoping Univ, Div Urol, Dept Clin & Expt Med, Linkoping, Sweden..
    Riklund, Katrine
    Umea Univ, Dept Radiat Sci, Diagnost Radiol, Umea, Sweden..
    Winerdal, Malin E.
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden..
    Krantz, David
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden..
    Zirakzadeh, A. Ali
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden.;Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden..
    Marits, Per
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden..
    Sjöholm, Louise K.
    Karolinska Inst, Dept Clin Neurosci, Ctr Mol Med, Stockholm, Sweden..
    Sherif, Amir
    Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden.;Umea Univ, Dept Radiat Sci, Diagnost Radiol, Umea, Sweden..
    Winqvist, Ola
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden..
    Increased CD4(+) T cell lineage commitment determined by CpG methylation correlates with better prognosis in urinary bladder cancer patients2018Inngår i: Clinical Epigenetics, E-ISSN 1868-7083, Vol. 10, artikkel-id 102Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Urinary bladder cancer is a common malignancy worldwide. Environmental factors and chronic inflammation are correlated with the disease risk. Diagnosis is performed by transurethral resection of the bladder, and patients with muscle invasive disease preferably proceed to radical cystectomy, with or without neoadjuvant chemotherapy. The anti-tumour immune responses, known to be initiated in the tumour and draining lymph nodes, may play a major role in future treatment strategies. Thus, increasing the knowledge of tumour-associated immunological processes is important. Activated CD4(+) T cells differentiate into four main separate lineages: Th1, Th2, Th17 and Treg, and they are recognized by their effector molecules IFN-gamma, IL-13, IL-17A, and the transcription factor Foxp3, respectively. We have previously demonstrated signature CpG sites predictive for lineage commitment of these four major CD4(+ )T cell lineages. Here, we investigate the lineage commitment specifically in tumour, lymph nodes and blood and relate them to the disease stage and response to neoadjuvant chemotherapy.

    Results: Blood, tumour and regional lymph nodes were obtained from patients at time of transurethral resection of the bladder and at radical cystectomy. Tumour-infiltrating CD4(+ )lymphocytes were significantly hypomethylated in all four investigated lineage loci compared to CD4(+) lymphocytes in lymph nodes and blood (lymph nodes vs rumour-infiltrating lymphocytes: IFNG -4229 bp p < 0.0001, IL13 -11 bp p < 0.05, IL17A -122 bp p < 0.01 and FOXP3 -77 bp p> 0.05). Examination of individual lymph nodes displayed different methylation signatures, suggesting possible correlation with future survival. More advanced post-cystectomy tumour stages correlated significantly with increased methylation at the IFNG -4229 bp locus. Patients with complete response to neoadjuvant chemotherapy displayed significant hypomethylation in CD4(+ )T cells for all four investigated loci, most prominently in IFNG p < 0.0001. Neoadjuvant chemotherapy seemed to result in a relocation of Th1-committed CD4(+) T cells from blood, presumably to the tumour, indicated by shifts in the methylation patterns, whereas no such shifts were seen for lineages corresponding to IL13, IL17A and FOXP3.

    Conclusion: Increased lineage commitment in CD4(+) T cells, as determined by demethylation in predictive CpG sites, is associated with lower post-cystectomy tumour stage, complete response to neoadjuvant chemotherapy and overall better outcome, suggesting epigenetic profiling of CD4(+) T cell lineages as a useful readout for clinical staging.

  • Banerjee, Souvik
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik.
    Bryan, Jan-Willem
    Univ Groningen, Van Swinderen Inst Particle Phys & Grav, Nijenborgh 4, NL-9747 AG Groningen, Netherlands..
    Vos, Gideon
    Univ Groningen, Van Swinderen Inst Particle Phys & Grav, Nijenborgh 4, NL-9747 AG Groningen, Netherlands..
    On the universality of late-time correlators in semi-classical 2d CFTs2018Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 8, artikkel-id 047Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In the framework of the AdS3/CFT2 correspondence, we present a systematic analysis of the late time thermalization of a two dimensional CFT state created by insertion of small number of heavy operators on the vacuum. We show that at late Lorentzian time, the universal features of this thermalization are solely captured by the eigenvalues of the monodromy matrix corresponding to the solutions of the uniformization equation. We discuss two different ways to extract the monodromy eigenvalues while bypassing the need for finding explicitly the full monodromy matrix - first, using a monodromy preserving diffeomorphism and second using Chen-Simons formulation of gravity in AdS(3). Both of the methods yield the same precise relation between the eigenvalues and the final black hole temperature at late Lorentzian time.

  • Bajraktari, Gani
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Kardiologi. Heart Centre, Umeå.
    Pugliese, Nicola Riccardo
    D'Agostino, Andreina
    Rosa, Gian Marco
    Ibrahimi, Pranvera
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin. Heart Centre, Umeå.
    Perçuku, Luan
    Miccoli, Mario
    Galeotti, Gian Giacomo
    Fabiani, Iacopo
    Pedrinelli, Roberto
    Henein, Michael
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Kardiologi. Heart Centre, Umeå.
    Dini, Frank L.
    Echo- and B-Type Natriuretic Peptide-Guided Follow-Up versus Symptom-Guided Follow-Up: Comparison of the Outcome in Ambulatory Heart Failure Patients2018Inngår i: Cardiology Research and Practice, ISSN 2090-8016, E-ISSN 2090-0597, artikkel-id 3139861Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Recent European Society of Cardiology and American Heart Association/American College of Cardiology Guidelines did not recommend biomarker-guided therapy in the management of heart failure (HF) patients. Combination of echo- and B-type natriuretic peptide (BNP) may be an alternative approach in guiding ambulatory HF management. Our aim was to determine whether a therapy guided by echo markers of left ventricular filling pressure (LVFP), lung ultrasound (LUS) assessment of B-lines, and BNP improves outcomes of HF patients. Consecutive outpatients with LV ejection fraction (EF) <= 50% have been prospectively enrolled. In Group I (n=224), follow-up was guided by echo and BNP with the goal of achieving E-wave deceleration time (EDT) >= 150 ms, tissue Doppler index E/e' < 13, B-line numbers < 15, and BNP <= 125 pg/ml or decrease > 30%; in Group II (n=293), follow-up was clinically guided, while the remaining 277 patients (Group III) did not receive any dedicated follow-up. At 60 months, survival was 88% in Group I compared to 75% in Group II and 54% in Group III (chi(2) 53.5; p<0.0001). Survival curves exhibited statistically significant differences using Mantel-Cox analysis. The number needed to treat to spare one death was 7.9 (Group I versus Group II) and 3.8 (Group I versus Group III). At multivariate Cox regression analyses, major predictors of all-cause mortality were follow-up E/e' (HR: 1.05; p=0.0038) and BNP > 125 pg/ml or decrease <= 30% (HR: 4.90; p=0.0054), while BNP > 125 pg/ml or decrease <= 30% and B-line numbers >= 15 were associated with the combined end point of death and HF hospitalization. Evidence-based HF treatment guided by serum biomarkers and ultrasound with the goal of reducing elevated BNP and LVFP, and resolving pulmonary congestion was associated with better clinical outcomes and can be valuable in guiding ambulatory HF management.

  • Johansson, Tomas
    et al.
    Utförare miljöövervakning, Länsstyrelser, lst, Länsstyrelsen Gotlands län.
    Tydén, Lars
    Häckande fåglar i skogsmark på Gotland 1998-20142018Rapport (Annet vitenskapelig)
    Abstract [sv]

    Samtliga år från 1998 till 2014 har länsstyrelsen låtit inventera häckfågelfaunan i skogsmark i 20 områden på Gotland. Inventeringen har skett enligt den metodik som utarbetats av svenska häckfågeltaxeringen och som består av en kombinerad linje- och punkttaxering längs 8 km långa och kvadratiska fasta standardrutter. Varje rutt har inventerats en gång per säsong (15 maj-15 juni) och av samma person (= Lars Tydén) alla 17 åren.

     

    Den överlägset vanligaste arten var föga förvånande lövsångaren, följd av trädpiplärka och taltrast. Ett dussintal av de typiska skogsarterna uppvisade en positiv populationsutveckling under de 17 åren. Störst var ökningen av skogs- och ringduva, rödhake, koltrast, svartmes och korp. Det var också positiva trender för trana, spillkråka, gärdsmyg, talgoxe och domherre. En tydlig negativ trend uppvisades för kungsfågel, blåmes och trädkrypare.

  • Fredriksson, Susanna
    et al.
    Linnéuniversitet.
    Nilsson, Jonas
    Undersökning av undervattensmiljön utanför Ölands norra udde2018Rapport (Annet vitenskapelig)
    Abstract [sv]

    Inom projektet Marina skyddsvärden runt Öland och Gotland inventerades i slutet av augusti 2017 marina naturvärden utanför Ölands norra udde. Bottentyp, arter och habitat inventerades i totalt 15 delområden ost och nordost om norra udden för att får ett bättre underlag vid havsplanering samt för länsstyrelsernas arbete med marint områdesskydd. Inom varje delområde filmades i storleksordningen 50 m2 bottenyta. Filmningen genomfördes med dropvideo i HD-kvalitet.

    Resultaten visar att sten och kalkstenshäll är de dominerande bottentyperna i stora delar av det inventerade området. Djupare än 15 m ökar generellt inslaget av sand och grus. Strandnära förekommer grundare sandbotten med möjlighet för olika arter av sjögräs att växa, men varken ålgräs, natingar eller hårsärv förekom på de filmade lokalerna. Ytmässigt dominerade rödalger (framförallt fjäderslick) samt blåmusslor, som förekom i hela området, där det finns lämpligt substrat. Blåmusslor täckte ofta mer än häften (50-75%) av bottenytan. Musslorna utgör en viktig födoresurs för rastande dykänder, och en tidigare inventering avsjöfågel visar att området är viktigt som övervintringsplats för bland annat alfågel och ejder. Tång förekom endast på 2 av de 75 lokalerna, runt 11m djup i området allra längst österut, 8 km från land.

    Sten och hällbottnarna i området är ofta plana och större blocksamlingar eller mer uppspruckna hällar med vertikala ytor förekommer sporadiskt. Det enformiga substratet och avsakanden av högvuxen algvegetation ger en undervattensmiljö med låg komplexitet och relativt få arter.

    Sammantaget bedöms det ändå finnas vissa naturvärden i området, framförallt kopplat till den ekologiska funktioen, då förekomsten av blåmusslor är betydelsefull för övervintrande dykänder. Sannolikt används även grunområdena som lekområde för olika arter av fisk. Naturtypen Rev klassas dessutom som ett sårbart och skyddsvärt habitat på Helcoms rödlista över hotade habitat i Östersjön.

  • Blanco-Cano, Xochitl
    et al.
    Univ Nacl Autonoma Mexico, Inst Geofis, Mexico City, DF, Mexico..
    Battarbee, Markus
    Univ Helsinki, Dept Phys, Helsinki, Finland..
    Turc, Lucile
    Univ Helsinki, Dept Phys, Helsinki, Finland..
    Dimmock, Andrew P.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutet för rymdfysik, Uppsalaavdelningen. Aalto Univ, Sch Elect Engn, Dept Elect & Nanoengn, Espoo, Finland..
    Kilpua, Emilia K. J.
    Univ Helsinki, Dept Phys, Helsinki, Finland..
    Hoilijoki, Sanni
    Univ Colorado, Lab Atmospher & Space Phys, Boulder, CO 80309 USA..
    Ganse, Urs
    Univ Helsinki, Dept Phys, Helsinki, Finland..
    Sibeck, David G.
    NASA, Goddard Space Flight Ctr, Greenbelt, MD USA..
    Cassak, Paul A.
    West Virginia Univ, Dept Phys & Astron, Morgantown, WV USA..
    Fear, Robert C.
    Univ Southampton, Dept Phys & Astron, Southampton, Hants, England..
    Jarvinen, Riku
    Aalto Univ, Sch Elect Engn, Dept Elect & Nanoengn, Espoo, Finland.;Finnish Meteorol Inst, Helsinki, Finland..
    Juusola, Liisa
    Univ Helsinki, Dept Phys, Helsinki, Finland.;Finnish Meteorol Inst, Helsinki, Finland..
    Pfau-Kempf, Yann
    Univ Helsinki, Dept Phys, Helsinki, Finland..
    Vainio, Rami
    Univ Turku, Dept Phys & Astron, Turku, Finland..
    Palmroth, Minna
    Univ Helsinki, Dept Phys, Helsinki, Finland.;Finnish Meteorol Inst, Helsinki, Finland..
    Cavitons and spontaneous hot flow anomalies in a hybrid-Vlasov global magnetospheric simulation2018Inngår i: Annales Geophysicae, ISSN 0992-7689, E-ISSN 1432-0576, Vol. 36, nr 4, s. 1081-1097Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this paper we present the first identification of foreshock cavitons and the formation of spontaneous hot flow anomalies (SHFAs) with the Vlasiator global magnetospheric hybrid-Vlasov simulation code. In agreement with previous studies we show that cavitons evolve into SHFAs. In the presented run, this occurs very near the bow shock. We report on SHFAs surviving the shock crossing into the down-stream region and show that the interaction of SHFAs with the bow shock can lead to the formation of a magnetosheath cavity, previously identified in observations and simulations. We report on the first identification of long-term local weakening and erosion of the bow shock, associated with a region of increased foreshock SHFA and caviton formation, and repeated shock crossings by them. We show that SHFAs are linked to an increase in suprathermal particle pitch-angle spreads. The realistic length scales in our simulation allow us to present a statistical study of global caviton and SHFA size distributions, and their comparable size distributions support the theory that SHFAs are formed from cavitons. Virtual spacecraft observations are shown to be in good agreement with observational studies.