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  • Almström Persson, Gunilla
    Stockholms universitet, Humanistiska fakulteten, Institutionen för svenska och flerspråkighet, Svenska/Nordiska språk.
    "Kredd till dig för vår senaste tweet": Kommunikativa val på Twitter under terrorattentatet på Drottninggatan2018Inngår i: Grammatik, kritik, didaktik: Nordiska studier i systemisk-funktionell lingvistik och socialsemiotik, Göteborg: Göteborgs universitet, 2018, Vol. 34, s. 79-95Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Kehoe, Kaat
    et al.
    Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Antwerp, Belgium.
    Noels, Heidi
    Rhein Westfal TH Aachen, Inst Mol Cardiovasc Res, Aachen, Germany.
    Theelen, Wendy
    Rhein Westfal TH Aachen, Inst Mol Cardiovasc Res, Aachen, Germany.
    De Hert, Emilie
    Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Antwerp, Belgium.
    Xu, Shenguan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk kemi.
    Verrijken, An
    Antwerp Univ Hosp, Dept Endocrinol Diabetol & Metab, Edegem, Belgium;Univ Antwerp, Fac Med & Hlth Sci, LEMP, Antwerp, Belgium.
    Arnould, Thierry
    Univ Namur UNamur, Namur Res Inst Life Sci NARILIS, Lab Biochem & Cell Biol URBC, Namur, Belgium.
    Fransen, Erik
    Univ Antwerp, StatUa Ctr Stat, Antwerp, Belgium.
    Hermans, Nina
    Univ Antwerp, Dept Pharmaceut Sci, Nat Prod & Food Res & Anal Nat, Antwerp, Belgium.
    Lambeir, Anne-Marie
    Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Antwerp, Belgium.
    Venge, Per
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk kemi.
    Van Gaal, Luc
    Antwerp Univ Hosp, Dept Endocrinol Diabetol & Metab, Edegem, Belgium;Univ Antwerp, Fac Med & Hlth Sci, LEMP, Antwerp, Belgium.
    De Meester, Ingrid
    Univ Antwerp, Dept Pharmaceut Sci, Lab Med Biochem, Antwerp, Belgium.
    Prolyl carboxypeptidase activity in the circulation and its correlation with body weight and adipose tissue in lean and obese subjects2018Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 5, artikkel-id e0197603Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background Prolyl carboxypeptidase (PRCP) is involved in the regulation of body weight, likely by hydrolysing alpha-melanocyte-stimulating hormone and apelin in the hypothalamus and in the periphery. A link between PRCP protein concentrations in plasma and metabolic disorders has been reported. In this study, we investigated the distribution of circulating PRCP activity and assessed its relation with body weight and adipose tissue in obese patients and patients who significantly lost weight. Methods PRCP activity was measured using reversed-phase high-performance liquid chromatography in different isolated blood fractions and primary human cells to investigate the distribution of circulating PRCP. PRCP activity was measured in serum of individuals (n = 75) categorized based on their body mass index (BMI < 25.0; 25.0-29.9; 30.0-39.9; >= 40.0 kg/m(2)) and the diagnosis of metabolic syndrome. Differences in serum PRCP activity were determined before and six months after weight loss, either by diet (n = 45) or by bariatric surgery (n = 24). Potential correlations between serum PRCP activity and several metabolic and biochemical parameters were assessed. Additionally, plasma PRCP concentrations were quantified using a sensitive ELISA in the bariatric surgery group. Results White blood cells and plasma contributed the most to circulating PRCP activity. Serum PRCP activity in lean subjects was 0.83 +/- 0.04 U/L and increased significantly with a rising BMI (p<0.001) and decreased upon weight loss (diet, p<0.05; bariatric surgery, p<0.001). The serum PRCP activity alteration reflected body weight changes and was found to be positively correlated with several metabolic parameters, including: total, abdominal and visceral adipose tissue. Plasma PRCP concentration was found to be significantly correlated to serum PRCP activity (0.865; p<0.001). Additionally, a significant decrease (p<0.001) in plasma PRCP protein concentration (mean +/- SD) before (18.2 +/- 3.7 ng/mL) and 6 months after bariatric surgery (15.7 +/- 2.7 ng/mL) was found. Conclusion Our novel findings demonstrate that white blood cells and plasma contributed the most to circulating PRCP activity. Additionally, we have shown that there were significant correlations between serum PRCP activity and various metabolic parameters, and that plasma PRCP concentration was significantly correlated to serum PRCP activity. These novel findings on PRCP activity in serum support further investigation of its in vivo role and involvement in several metabolic diseases.

  • Zalkalns, Lilita
    Stockholms universitet, Humanistiska fakulteten, Institutionen för slaviska och baltiska språk, finska, nederländska och tyska, Baltiska språk.
    Dzimtenes Balss pielikumi2017Inngår i: Jaunā Gaita, ISSN 0448-9179, Vol. LXIV, nr 291, s. 40-46Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    Between 1955 and 1992, Latvians in the western exile received the propaganda publication "Dzimtenes Balss", which was written by and published by the Cultural Relations Committee in Riga, a KGB-front whose goal was to neutralize exile Latvian anti-Communistic activities. Beginning 1964, "Dzimtenes Balss" published a number of supplements that targeted exile Latvian activitists and organizations. The supplements, among them Svešuma Balss, Svešatnes Atspulgi, Latvia Today, et al, were published in Latvian and in English.

  • Almström Persson, Gunilla
    Stockholms universitet, Humanistiska fakulteten, Institutionen för svenska och flerspråkighet, Svenska/Nordiska språk.
    Det politiska reportaget: Om ögonvittnesskildring som persuasivt medel2018Inngår i: Kritiska text- och diskursstudier / [ed] Daniel Wojahn, Charlotta Seiler Brylla, Gustav Westberg, Hudding: Södertörns högskola, 2018, Vol. 6, s. 161-177Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    This paper use rhetorical criticism methodology when investigating linguistic and rhetorical means in the reportage genre. The concept of eye-witness is explored in six reportage from the GDR-propaganda published in 1962. Through analysis of dialogue and perception in text, the notion of presence is discussed. An assumption is that presence in text can be of paramount importance for the technique of persuasion. It  is claimed that presence might be communicated though dialogues. However the main impact of presence is connected to the perceptivity of the narrator. Values and arguments are highly emphasized when detailed descriptions are experienced by the narrator. Consequently the conclusion of the analysis is associated with the rhetorical concept evidentia. Finally it is claimed that the GDR-propaganda use reportage from industries and construction sites to show western countries the advantages of East German version of socialism. The concept of political myth is introduced and is in the final discussion connected to the myth of technical development and the myth of progress. The theoretical frame-work consists of rhetoric, linguistics, and literary studies.

  • Zalkalns, Lilita
    Stockholms universitet, Humanistiska fakulteten, Institutionen för slaviska och baltiska språk, finska, nederländska och tyska, Baltiska språk.
    Uldis Ģērmanis un izdevniecība "Memento"2016Inngår i: Jaunā Gaita, ISSN 0448-9179, Vol. LXII, nr 284, s. 53-55Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    A summary of historian, publicist, and author Uldis Ģērmanis' collaboration with publishing house "Memento". "Memento" was established in Stockholm 1961, by leading exile Latvian socialdemocrats. Between 1986 and 1998 "Memento" published eleven books authored by Uldis Ģērmanis.

  • Pettersson, John H.-O.
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway;Univ Sydney, Charles Perkins Ctr, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia;Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia;Natl Vet Inst, Dept Microbiol, Uppsala, Sweden.
    Bohlin, Jon
    Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
    Dupont-Rouzeyrol, Myrielle
    Inst Pasteur Nouvelle Caledonie, Unite Rech Expertise Dengue & Autres Arboviroses, Noumea, New Caledonia.
    Brynildsrud, Ola B.
    Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
    Alfsnes, Kristian
    Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
    Cao-Lormeau, Van-Mai
    Inst Louis Malarde, Unit Emerging Infect Dis, Tahiti, French Polynesi, France;Aix Marseille Univ, IHU Mediterranee Infect, VITROME, IRD,AP HM,SSA, Marseille, France.
    Gaunt, Michael W.
    London Sch Hyg & Trop Med, London, England.
    Falconar, Andrew K.
    Univ Norte, Dept Med, Barranquilla, Colombia.
    De Lamballerie, Xavier
    Aix Marseille Univ, UMR Unite Virus Emergents, IRD 190, IHU Mediterranee Infect,Inserm 1207, Marseille, France;Univ Mediterranee Infect, Inst Hosp, Publ Hosp Marseille, AP HM, Marseille, France.
    Eldholm, Vegard
    Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
    Musso, Didier
    Inst Louis Malarde, Unit Emerging Infect Dis, Tahiti, French Polynesi, France;Aix Marseille Univ, IHU Mediterranee Infect, VITROME, IRD,AP HM,SSA, Marseille, France.
    Gould, Ernest A.
    Aix Marseille Univ, UMR Unite Virus Emergents, IRD 190, IHU Mediterranee Infect,Inserm 1207, Marseille, France.
    Re-visiting the evolution, dispersal and epidemiology of Zika virus in Asia2018Inngår i: EMERGING MICROBES & INFECTIONS, ISSN 2222-1751, Vol. 7, artikkel-id 79Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Based on serological evidence and viral isolation, Zika virus (ZIKV) has circulated for many years relatively benignly in a sylvatic cycle in Africa and an urban cycle in South East Asia (SEA). With the recent availability of limited but novel Indian ZIKV sequences to add to the plethora of SEA sequences, we traced the phylogenetic history and spatio-temporal dispersal pattern of ZIKV in Asia prior to its explosive emergence in the Pacific region and the Americas. These analyses demonstrated that the introduction and dispersal of ZIKV on the Pacific islands were preceded by an extended period of relatively silent transmission in SEA, enabling the virus to expand geographically and evolve adaptively before its unanticipated introduction to immunologically naive populations on the Pacific islands and in the Americas. Our findings reveal new features of the evolution and dispersal of this intriguing virus and may benefit future disease control strategies.

  • Byass, Peter
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa. MRC/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Education Campus, University of Witwatersrand, Parktown, South Africa.
    Jackson Cole, Catherine
    Davies, Justine I.
    Geldsetzer, Pascal
    Witham, Miles D.
    Wu, Yan
    Collaboration for impact in global health2018Inngår i: The Lancet Global Health, E-ISSN 2214-109X, Vol. 6, nr 8, s. e836-e837Artikkel i tidsskrift (Fagfellevurdert)
  • Nyberg, Erik
    et al.
    Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, Maskinelement.
    Minami, Ichiro
    Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, Maskinelement.
    Boundary Film Formation from Hydrocarbon-mimicking Ionic Liquids2017Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Ionic liquids have properties that are very useful in high performance lubricants. However, they must be well tuned to the tribological system. Hydrocarbon-mimicking ionic liquids have been developed in an effort to overcome some of the compatibility problems that are holding back the use of ionic liquids in tribology. In this work, hydrocarbon-mimicking ionic liquids are evaluated as base fluids in steel-steel reciprocating tribotests. Wear and friction reducing boundary films are formed and found to be composed mainly of Si and O. An amine additive is found to stimulate the formation of this boundary film.

  • Nordmark, Marie
    Högskolan Dalarna, Akademin Humaniora och medier, Svenska språket.
    Att skriva med och utan digitala redskap2018Inngår i: Skolverket, Läslyftet. Språk-, läs- och skrivutveckling Grundskola F-3. Modul: Tidig läs- och skrivundervisning. Del 7: Att skriva med och utan digitala redskap., Stockholm: Skolverket , 2018Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [sv]

    Del 7. Att skriva med och utan digitala verktyg

    Syftet med den här delen är att fördjupa förståelsen för skrivande med och utan digitala verktyg i skrivundervisningen.

    Lärare behöver vid planering och genomförande av undervisning såväl som vid bedömning göra didaktiska val utifrån vad det innebär för elevernas skrivutveckling att använda olika skrivverktyg. Utifrån detta diskuteras här olika val lärare ställs inför och vad de kan innebära. 

    I undervisningsaktiviteten får ni möjlighet att arbeta med ord och bild i samspel. Syftet är att ge eleverna möjlighet att reflektera över innehållet utifrån ett mottagarperspektiv.

  • Ranängen, Helena
    et al.
    Luleå tekniska universitet, Institutionen för ekonomi, teknik och samhälle, Industriell Ekonomi.
    Cöster, Mathias
    Department of Business Studies, Uppsala University.
    Isaksson, Raine
    Department of Engineering Sciences, Quality Sciences, Uppsala Universit.
    Garvare, Rickard
    Luleå tekniska universitet, Institutionen för ekonomi, teknik och samhälle, Industriell Ekonomi.
    From global goals and planetary boundaries to public governance: A framework for prioritizing organizational sustainability activities2018Inngår i: Sustainability, ISSN 2071-1050, E-ISSN 2071-1050, Vol. 10, nr 8, artikkel-id 2741Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: A particular challenge in the work to realize the global goals for sustainable development is to find ways for organizations to identify and prioritize organizational activities that address these goals. There are also several sustainability initiatives, guidelines and tools to consider when planning, working with and reporting on sustainable development. Although progress has been made, little has been written about how organizations rise to and manage the challenge. The paper explores how organizations address sustainable development, which sustainability aspects they prioritize and whether previous research can improve the priority process by using materiality analysis approach. Methods: A case study approach was chosen. Data was collected by interactive workshops and documentation. The participating organizations were two Swedish municipalities; Results: The municipalities have introduced a number of sustainability aspects into their organizational governance, especially in terms of society, human rights and the environment. A materiality analysis was conducted to determine the relevance and significance of sustainability aspects. The result shows that climate action, biodiversity and freshwater use are aspects that should be prioritized; Conclusion: The materiality analysis methodology chosen for prioritizing of sustainability aspects was useful and easy to work with. However, the sustainability aspect matrix and the risk assessment have to be updated regularly in order to form an effective base for the materiality analysis.

  • Disputas: 2018-08-31 13:00 11D121, Karlstad
    Kjeang, Are
    Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), Institutionen för ingenjörs- och kemivetenskaper (from 2013).
    Goda råd är inte dyra!: Om personlig energirådgivning i ett alltmer digitaliserat samhälle2018Licentiatavhandling, med artikler (Annet vitenskapelig)
    Abstract [sv]

    ”Nu är goda råd dyra”, heter det sedan gammalt i en svensk krissituation. I denna licentiatavhandling, vars rubrik kopplar till talesättet, behandlas svensk energirådgivnings utveckling och framtid. Forskning visar att i ett alltmer digitaliserat samhälle behöver energirådgivningen utvecklas för att bättre nå målgrupperna - hushåll, småföretag och organisationer. Digitala tjänster ger många möjligheter, men den viktiga personliga kontakten med energirådgivaren går inte att ersätta fullt ut. Med hjälp av fokusgrupper, intervjuer och samtal med energirådgivare, villaägare och enskilda experter har kunnat konstateras att den personligt genomförda rådgivningstjänsten är efterfrågad, angelägen och framgångsrik när byte av värmesystem, större ombyggnationer eller nybyggnationer är aktuellt. Att pröva idéer och lösningar, helst i hemmamiljön inför en ombyggnad, är uppskattad rådgivning. I samtalet, där inte enbart tekniska detaljer och lönsamhet diskuteras, kan alla i hushållet engageras. Energirådgivningen kan bli mer framgångsrik, men då krävs ett större kommunalt engagemang och en tydligare samverkan med andra statliga styrmedel. Hållbara råd kan alla få i Sverige idag och de goda råden är gratis! Med hjälp av dessa kan kanske kriser undvikas…

  • Bauer, Barbara
    et al.
    Meier, Markus
    SMHI, Forskningsavdelningen, Oceanografi.
    Casini, Michele
    Hoff, Ayoe
    Margonski, Piotr
    Orio, Alessandro
    Saraiva, Sofia
    SMHI, Forskningsavdelningen, Oceanografi.
    Steenbeek, Jeroen
    Tomczak, Maciej T.
    Reducing eutrophication increases spatial extent of communities supporting commercial fisheries: a model case study2018Inngår i: ICES Journal of Marine Science, ISSN 1054-3139, E-ISSN 1095-9289, Vol. 75, nr 4, s. 1306-1317Artikkel i tidsskrift (Fagfellevurdert)
  • Jose Perez-Palazon, Maria
    et al.
    Pimentel, Rafael
    SMHI, Forskningsavdelningen, Hydrologi.
    Jose Polo, Maria
    Climate Trends Impact on the Snowfall Regime in Mediterranean Mountain Areas: Future Scenario Assessment in Sierra Nevada (Spain)2018Inngår i: Water, ISSN 2073-4441, E-ISSN 2073-4441, Vol. 10, nr 6, artikkel-id 720Artikkel i tidsskrift (Fagfellevurdert)
  • Mukkavaara, Jani
    et al.
    Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, Industriellt och hållbart byggande.
    Jansson, Gustav
    Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, Industriellt och hållbart byggande.
    Olofsson, Thomas
    Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, Industriellt och hållbart byggande.
    Structuring information from BIM: A glance at bills of materials2018Inngår i: Proceedings of the 35th ISARC, Berlin, Germany, 2018, s. 362-368Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Industrialized house-builders are moving towards an enhanced production where management of information along the value chain is critical in order to deliver housing projects on time and with the desired quality. Today digital tools and systems are used in both design and production to produce, deliver and instruct actors throughout the phases of aproject. However, the information usually exists in different islands and manual transfers are required tokeep the flow of information between IT-systems and individuals continuous. A key to improving the ability for the members in different stages of a project to work with the same information is to facilitate different views. One of the building blocks for creating bridges between the islands of information is to introduce bills of materials which can be used to organize information for different purposes. Uniting the use of building information modeling (BIM) withbills of materials (BOM) is therefore our focus in this paper. This is done in the context of industrialized house-building and the facets which it brings to the subject. The aim of this paper is to present an early endeavor into a BOM based approach for structuring information from BIM models. A demonstration tool was developed, and together with application in a case project from an industrialized house-builder, the generation of BOMs from BIM data is illustrated and discussed. The findings illustrates that we can apply different structures to the information located in our BIM models and that we can produce a BOM perspective on our products. Also, it is highlighted that we still need further studies to better understand how application of BOMs in the context of industrialized house-building is realized.

  • Callou, Dinah
    et al.
    Avelar, Juanito
    University of Campinas, Brazil.
    TER/HAVER constructions and verbal agreement2013Inngår i: Journal of Portuguese Linguistics, ISSN 1645-4537, E-ISSN 2397-5563, Vol. 12, nr 2, s. 187-208Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of this paper is twofold: (i) to analyze the use of the verbs ter and haver in the history of Portuguese and, more specifically, in a recent stage of Brazilian Portuguese, in which the possessive ter is used as an existential verb; and (ii) to discuss some properties involving ter and haver in possessive and existential domains, in both European and Brazilian Portuguese, pointing to the possibility of verbal agreement with ter/haver-existential constructions. Exploring results from previous analyses it is shown that some properties of existential constructions, in contemporary Brazilian Portuguese, can derive from changes involving subject position, related to the weakening of flectional paradigm.

  • Avelar, Juanito
    et al.
    University of Campinas, Brazil.
    Galves, Charlotte
    O papel das línguas africanas na emergência da gramática do português brasileiro2014Inngår i: Lingüística, ISSN 1132-0214, Vol. 30, nr 2, s. 241-288Artikkel i tidsskrift (Fagfellevurdert)
  • Ornelas de Avelar, Juanito
    University of Campinas, Brazil.
    Sentenças possessivas e existenciais2018Inngår i: História do Português Brasileiro: Mudança sintática: perspectiva gerativista / [ed] Ataliba T. de Castilho, Maria A. Torres Morais, Sonia Cyrino, São Paulo: Editora Contexto , 2018, s. 72-49Kapittel i bok, del av antologi (Fagfellevurdert)
  • Donzel-Gargand, Olivier
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik.
    Thersleff, Thomas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap. Stockholm University.
    Keller, Jan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik.
    Törndahl, Tobias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik.
    Larsson, Fredrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik.
    Wallin, Erik
    Solibro Research AB, Uppsala, Sweden.
    Stolt, Lars
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik. Solibro Research AB, Uppsala, Sweden.
    Edoff, Marika
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik.
    Deep surface Cu depletion induced by K in high-efficiency Cu(In,Ga)Se2 solar cell absorbers2018Inngår i: Progress in Photovoltaics, ISSN 1062-7995, E-ISSN 1099-159XArtikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this work, we used K‐rich glass substrates to provide potassium during the coevaporation of Cu(In,Ga)Se2 (CIGS) absorber layers. Subsequently, we applied a postdeposition treatment (PDT) using KF or RbF to some of the grown absorbers. It was found that the presence of K during the growth of the CIGS layer led to cell effi- ciencies beyond 17%, and the addition of a PDT pushed it beyond 18%. The major finding of this work is the observation of discontinuous 100‐ to 200‐nm‐deep Cu‐ depleted patches in the vicinity of the CdS buffer layer, correlated with the presence of K during the growth of the absorber layer. The PDT had no influence on the forma- tion of these patches. A second finding concerns the composition of the Cu‐depleted areas, where an anticorrelation between Cu and both In and K was measured using scanning transmission electron microscopy. Furthermore, a steeper Ga/(In+Ga) ratio gradient was measured for the absorbers grown with the presence of K, suggesting that K hinders the group III element interdiffusion. Finally, no Cd in‐diffusion to the CIGS layer could be detected. This indicates that if CdCu substitution occurs, either their concentration is below our instrumental detection limit or its presence is contained within the first 6 nm from the CdS/CIGS interface.

  • Al-Douri, Yamur K.
    et al.
    Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, Drift, underhåll och akustik.
    Hamodi, Hussan
    Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, Drift, underhåll och akustik.
    Lundberg, Jan
    Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, Drift, underhåll och akustik.
    Time Series Forecasting using a Two-level Multi-objective Genetic Algorithm: A case study of cost data for tunnel fans2018Inngår i: Algorithms, ISSN 1999-4893, Vol. 11, nr 8, artikkel-id 123Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of this study is to develop a novel two-level multi-objective genetic algorithm (GA) to optimize time series forecasting data for fans used in road tunnels by the Swedish Transport Administration (Trafikverket). The first level is for the process of forecasting time series cost data, while the second level evaluates the forecasting. The first level implements either a multi-objective GA based on the ARIMA model or based on the dynamic regression model. The second level utilises a multi-objective GA based on different forecasting error rates to identify a proper forecasting. Our method is compared with the ARIMA model only. The results show the drawbacks of time series forecasting using the ARIMA model. In addition, the results of the two-level model show the drawbacks of forecasting using a multi-objective GA based on the dynamic regression model. A multi-objective GA based on the ARIMA model produces better forecasting results. In the second level, five forecasting accuracy functions help in selecting the best forecasting. Selecting a proper methodology for forecasting is based on the averages of the forecasted data, the historical data, the actual data and the polynomial trends. The forecasted data can be used for life cycle cost (LCC) analysis.

  • Sundberg, Henrik
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Systematisk biologi.
    Kruys, Åsa
    Uppsala universitet, Enheten för musik och museer, Evolutionsmuseet.
    Bergsten, Johannes
    Naturhistoriska riksmuseet, Stockholm, Sweden.
    Ekman, Stefan
    Uppsala universitet, Enheten för musik och museer, Evolutionsmuseet.
    Position specificity in the genus Coreomyces (Laboulbeniomycetes, Ascomycota)2018Inngår i: Fungal Systematics and Evolution, ISSN 2589-3823, Vol. 1, nr 1, s. 217-228Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    To study position specificity in the insect-parasitic fungal genus Coreomyces (Laboulbeniaceae, Laboulbeniales), we sampled corixid hosts (Corixidae, Heteroptera) in southern Scandinavia. We detected Coreomyces thalli in five different positions on the hosts. Thalli from the various positions grouped in four distinct clusters in the resulting gene trees, distinctly so in the ITS and LSU of the nuclear ribosomal DNA, less so in the SSU of the nuclear ribosomal DNA and the mitochondrial ribosomal DNA. Thalli from the left side of abdomen grouped in a single cluster, and so did thalli from the ventral right side. Thalli in the mid-ventral position turned out to be a mix of three clades, while thalli growing dorsally grouped with thalli from the left and right abdominal clades. The mid-ventral and dorsal positions were found in male hosts only. The position on the left hemelytron was shared by members from two sister clades. Statistical analyses demonstrate a significant positive correlation between clade and position on the host, but also a weak correlation between host sex and clade membership. These results indicate that sex-of-host specificity may be a non-existent extreme in a continuum, where instead weak preferences for one host sex may turn out to be frequent.

  • Käihkö, Ilmari
    Försvarshögskolan, Institutionen för säkerhet, strategi och ledarskap (ISSL), Strategiavdelningen.
    The MODEL social structure of an armed group: From Liberian refugees to heroes of Côte d’Ivoire and liberators of the homeland2018Inngår i: Small Wars & Insurgencies, ISSN 0959-2318, E-ISSN 1743-9558, Vol. 29, nr 4, s. 776-800Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article investigates the Movement for Democracy in Liberia (MODEL) through a revised Weberian framework that focuses on legitimacy and offers a thick description of the different phases of this armed group. The article argues that the key to fostering cohesion is the harmonization of the micro, meso, and macro levels. This proved a difficult undertaking for the MODEL. Not only did the MODEL lack material resources but it also relied on different and evolving kinds of legitimacy on these levels. With its sources of legitimacy exhausted after the war, the MODEL ceased to exist.

  • Spang, Anja
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär evolution. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Royal Netherlands Inst Sea Res, Dept Marine Microbiol & Biogeochem, NIOZ, Den Burg, Netherlands.; Univ Utrecht, Den Burg, Netherlands.
    Eme, Laura
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär evolution. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Saw, Jimmy H.
    Oregon State Univ, Dept Microbiol, Corvallis, OR USA.
    Fernández Cáceres, Eva
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär evolution. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Zaremba-Niedzwiedzka, Katarzyna
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär evolution. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Lombard, Jonathan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär evolution. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Guy, Lionel
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär evolution. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Ettema, Thijs J. G.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär evolution. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Asgard archaea are the closest prokaryotic relatives of eukaryotes2018Inngår i: PLoS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 14, nr 3, artikkel-id e1007080Artikkel i tidsskrift (Annet vitenskapelig)
  • Moll, Jonas
    et al.
    Uppsala University, Uppsala.
    Rexhepi, Hanife
    University of Skövde, School of Informatics. The Informatics Research Centre.
    Cajander, Åsa
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computerized Image Analysis and Human-Computer Interaction..
    Grünloh, Christiane
    KTH, Skolan för elektroteknik och datavetenskap (EECS).
    Hägglund, Maria
    Karolinska Institutet, Health Informatics Centre.
    Huvila, Isto
    Åbo Akademi University, Faculty of Social Sciences and Economics.
    Myreteg, Gunilla
    Uppsala University, Department of Information Technology, Department of Business Studies.
    Scandurra, Isabella
    Örebro University.
    Åhlfeldt, Rose-Mharie
    University of Skövde, School of Informatics. The Informatics Research Centre.
    Patients’ Experiences of Accessing Their Online Electronic Health Records: Results of a National Patient Survey in SwedenInngår i: Journal of Medical Internet Research, ISSN 1438-8871, E-ISSN 1438-8871Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Internationally, there is movement towards providing patients online access to their electronic health record (EHR).  In Sweden, Region Uppsala was the first to introduce patient accessible electronic health records (PAEHRs) in 2012. By the summer of 2016, 17 out of 21 county councils had given citizens the possibility to access their medical information online. Studies on the effect of PAEHRs on the work environment of healthcare professionals have been carried out, but up until now few extensive studies have been carried out regarding patients’ experiences with using PAEHRs in Sweden or Europe more generally.

    Objectives: The aim of the study was to investigate patients’ experiences of accessing their electronic health records through the Swedish national patient portal. In this paper, the focus is on describing user characteristics, usage, and attitudes towards the system.

    Methods: A national patient survey was designed, based on previous interview and survey studies with patients and healthcare professionals. Data was collected during a five month period in 2016. The survey was made available through the PAEHR system, called Journalen, in Sweden. The total number of patients that logged in and could access the survey during the study period was 423141. In addition to descriptive statistics reporting response frequencies on Likert-scale questions, Mann-Whitney tests, Kruskal-Wallis tests and Chi-square tests were also used to compare answers between different county councils as well as between respondents working in healthcare and all other respondents.

    Results: 2587 users completed the survey, giving a response rate of 0.61%. Two participants were excluded from the analysis, since they had only received care in a county council which did not yet show any information in Journalen. The results showed that 67% of the respondents were women, and 42% were working or had been working within healthcare. 72% of the respondents used Journalen about once a month and the main reason for use was to gain an overview of one’s health status. Furthermore, 98% of the respondents reported that lab results were the most important information for them to access. 69% of the respondents wanted access to new information within a day and 87% of the users reported that they are positive towards Journalen.

    Conclusions: The respondents provided several important reasons for why they use Journalen and why it is important for them to be able to access information in this way - several related to patient empowerment, involvement, and security. Considering the overall positive attitude, PAEHRs seem to fill important needs for patients.

  • Immonen, Elina
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Evolutionsbiologi.
    Hämäläinen, Anni
    Univ Alberta, Dept Biol Sci, Edmonton, Canada.
    Schuett, Wiebke
    Univ Hamburg, Inst Zool, Hamburg, Germany.
    Tarka, Maja
    Norwegian Univ Sci & Technol NTNU, Ctr Biodivers Dynam, Dept Biol, Trondheim, Norway.
    Evolution of sex-specific pace-of-life syndromes: genetic architecture and physiological mechanisms2018Inngår i: Behavioral Ecology and Sociobiology, ISSN 0340-5443, E-ISSN 1432-0762, Vol. 72, nr 3, artikkel-id UNSP 60Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Sex differences in life history, physiology, and behavior are nearly ubiquitous across taxa, owing to sex-specific selection that arises from different reproductive strategies of the sexes. The pace-of-life syndrome (POLS) hypothesis predicts that most variation in such traits among individuals, populations, and species falls along a slow-fast pace-of-life continuum. As a result of their different reproductive roles and environment, the sexes also commonly differ in pace-of-life, with important consequences for the evolution of POLS. Here, we outline mechanisms for how males and females can evolve differences in POLS traits and in how such traits can covary differently despite constraints resulting from a shared genome. We review the current knowledge of the genetic basis of POLS traits and suggest candidate genes and pathways for future studies. Pleiotropic effects may govern many of the genetic correlations, but little is still known about the mechanisms involved in trade-offs between current and future reproduction and their integration with behavioral variation. We highlight the importance of metabolic and hormonal pathways in mediating sex differences in POLS traits; however, there is still a shortage of studies that test for sex specificity in molecular effects and their evolutionary causes. Considering whether and how sexual dimorphism evolves in POLS traits provides a more holistic framework to understand how behavioral variation is integrated with life histories and physiology, and we call for studies that focus on examining the sex-specific genetic architecture of this integration.

  • Hamdan, Mohammed
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och geovetenskap.
    Byström, Pär
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och geovetenskap.
    Hotchkiss, Erin R.
    Al-Haidarey, Mohammed J.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och geovetenskap.
    Ask, Jenny
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och geovetenskap.
    Karlsson, Jan
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och geovetenskap.
    Carbon dioxide stimulates lake primary production2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 10878Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Gross primary production (GPP) is a fundamental ecosystem process that sequesters carbon dioxide (CO2) and forms the resource base for higher trophic levels. Still, the relative contribution of different controls on GPP at the whole-ecosystem scale is far from resolved. Here we show, by manipulating CO2 concentrations in large-scale experimental pond ecosystems, that CO2 availability is a key driver of whole-ecosystem GPP. This result suggests we need to reformulate past conceptual models describing controls of lake ecosystem productivity and include our findings when developing models used to predict future lake ecosystem responses to environmental change.

  • Pierozan, Paula
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Jernerén, Fredrik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Karlsson, Oskar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Perfluorooctanoic acid (PFOA) exposure promotes proliferation, migration and invasion potential in human breast epithelial cells2018Inngår i: Archives of Toxicology, ISSN 0340-5761, E-ISSN 1432-0738, Vol. 92, nr 5, s. 1729-1739Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Despite significant advances in early detection and treatment, breast cancer remains a major cause of morbidity and mortality. Perfluorooctanoic acid (PFOA) is a suspected endocrine disruptor and a common environmental pollutant associated with various diseases including cancer. However, the effects of PFOA and its mechanisms of action on hormone-responsive cells remain unclear. Here, we explored the potential tumorigenic activity of PFOA (100 nM-1 mM) in human breast epithelial cells (MCF-10A). MCF-10A cells exposed to 50 and 100 mu M PFOA demonstrated a higher growth rate compared to controls. The compound promoted MCF-10A proliferation by accelerating G(0)/G(1) to S phase transition of the cell cycle. PFOA increased cyclin D1 and CDK4/6 levels, concomitant with a decrease in p27. In contrast to previous studies of perfluorooctane sulfate (PFOS), the estrogen receptor antagonist ICI 182,780 had no effect on PFOA-induced cell proliferation, whereas the PPAR alpha antagonist GW 6471 was able to prevent the MCF-10A proliferation, indicating that the underlying mechanisms involve PPAR alpha-dependent pathways. Interestingly, we also showed that PFOA is able to stimulate cell migration and invasion, demonstrating its potential to induce neoplastic transformation of human breast epithelial cells. These results suggest that more attention should be paid to the roles of PFOA in the development and progression of breast cancer.

  • Berger, Eloise
    et al.
    Delpierre, Cyrille
    Hosnijeh, Fatemeh Saberi
    Kelly-Irving, Michelle
    Portengen, Lutzen
    Bergdahl, Ingvar
    Umeå universitet, Medicinska fakulteten, Enheten för biobanksforskning.
    Johansson, Ann Sofie
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Krogh, Vittorio
    Palli, Domenico
    Panico, Salvatore
    Sacerdote, Carlotta
    Tumino, Rosario
    Kyrtopoulos, Soterios A.
    Vineis, Paolo
    Chadeau-Hyam, Marc
    Vermeulen, Roel
    Castagné, Raphaële
    Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: findings from two prospective cohorts2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 10805Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflammatory score is associated with breast cancer (BC) and.-cell Non-Hodgkin Lymphoma (B-cell NHL, including 68 multiple myeloma cases) onset. We modelled the relationship between this inflammatory score and the two cancers studied: (BC and B-cell NHL) using generalised linear models, and assessed, through adjustments the role of behaviours and lifestyle factors. Analyses were performed by cancer types pooling both populations, and stratified by cohorts, and time to diagnosis. Our results suggested a lower inflammatory score in B-cell NHL cases (β = -1.28, p = 0.012), and, to lesser, extent with BC (β= -0.96, p = 0.33) compared to controls, mainly driven by cancer cases diagnosed less than 6 years after enrolment. These associations were not affected by subsequent adjustments for potential intermediate confounders, notably behaviours. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated. These observations call for further studies involving larger populations, larger variety of cancer types and repeated measures of larger panel of inflammatory markers.

  • Bolin, Sara
    et al.
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.
    Borgenvik, Anna
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Persson, Camilla U.
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.
    Sundström, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Qi, Jun
    Harvard Med Sch, Dept Med, Boston, MA USA;Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA.
    Bradner, James E.
    Harvard Med Sch, Dept Med, Boston, MA USA;Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA.
    Weiss, William A.
    Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA;Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA;Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA USA.
    Cho, Yoon-Jae
    Oregon Hlth & Sci Univ, Dept Pediat, Pape Family Pediat Res Inst, Knight Canc Inst, 3181 Sw Sam Jackson Pk Rd, Portland, OR 97201 USA.
    Weishaupt, Holger
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala Univ, Dept Immunol Genet & Pathol, Sci Life Lab, Rudbeck Lab, Uppsala, Sweden.
    Swartling, Fredrik J.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma2018Inngår i: Oncogene, ISSN 0950-9232, E-ISSN 1476-5594, Vol. 37, nr 21, s. 2850-2862Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Medulloblastoma (MB) is the most common malignant brain tumor in children. MYC genes are frequently amplified and correlate with poor prognosis in MB. BET bromodomains recognize acetylated lysine residues and often promote and maintain MYC transcription. Certain cyclin-dependent kinases (CDKs) are further known to support MYC stabilization in tumor cells. In this report, MB cells were suppressed by combined targeting of MYC expression and MYC stabilization using BET bromodomain inhibition and CDK2 inhibition, respectively. Such combination treatment worked synergistically and caused cell cycle arrest as well as massive apoptosis. Immediate transcriptional changes from this combined MYC blockade were found using RNA-Seq profiling and showed remarkable similarities to changes in MYC target gene expression when MYCN was turned off with doxycycline in our MYCN-inducible animal model for Group 3 MB. In addition, the combination treatment significantly prolonged survival as compared to single-agent therapy in orthotopically transplanted human Group 3 MB with MYC amplifications. Our data suggest that dual inhibition of CDK2 and BET bromodomains can be a novel treatment approach for suppressing MYC-driven cancer.

  • Valerio, Aline de Matos
    et al.
    Kampel, Milton
    Vantrepotte, Vincent
    Ward, Nicholas D.
    Sawakuchi, Henrique Oliveira
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och geovetenskap. Universidade de São Paulo, USP/CENA, Piracicaba, SP, Brazil .
    Da Silva Less, Diani Fernanda
    Neu, Vania
    Cunha, Alan
    Richey, Jeffrey
    Using CDOM optical properties for estimating DOC concentrations and pCO2 in the Lower Amazon River2018Inngår i: Optics Express, ISSN 1094-4087, E-ISSN 1094-4087, Vol. 26, nr 14, s. A657-A677Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Coloured dissolved organic matter (CDOM) is one of the major contributors to the absorption budget of most freshwaters and can be used as a proxy to assess non-optical carbon fractions such as dissolved organic carbon (DOC) and the partial pressure of carbon dioxide (pCO2). Nevertheless, riverine studies that explore the former relationships are still relatively scarce, especially within tropical regions. Here we document the spatial-seasonal variability of CDOM, DOC and pCO2, and assess the potential of CDOM absorption coefficient (aCDOM(412)) for estimating DOC concentration and pCO2 along the Lower Amazon River. Our results revealed differences in the dissolved organic matter (DOM) quality between clearwater (CW) tributaries and the Amazon River mainstream. A linear relationship between DOC and CDOM was observed when tributaries and mainstream are evaluated separately (Amazon River: N = 42, R2 = 0.74, p<0.05; CW: N = 13, R2 = 0.57, p<0.05). However, this linear relationship was not observed during periods of higher rainfall and river discharge, requiring a specific model for these time periods to be developed (N = 25, R2 = 0.58, p<0.05). A strong linear positive relation was found between aCDOM(412) and pCO2(N = 69, R2 = 0.65, p<0.05) along the lower river. pCO2 was less affected by the optical difference between tributaries and mainstream waters or by the discharge conditions when compared to CDOM to DOC relationships. Including the river water temperature in the model improves our ability to estimate pCO(2) (N = 69; R2 = 0.80, p<0.05). The ability to assess both DOC and pCO2 from CDOM optical properties opens further perspectives on the use of ocean colour remote sensing data for monitoring carbon dynamics in large running water systems worldwide.

  • Nolin, Jan
    Högskolan i Borås, Akademin för bibliotek, information, pedagogik och IT.
    Defining transparency movements2018Inngår i: Journal of Documentation, ISSN 0022-0418, E-ISSN 1758-7379, Vol. 74, nr 5, s. 1025-1041Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose – A multitude of transparency movements have been developed and grown strong in recentdecades. Despite their growing influence, scholarly studies have focused on individual movements.The purpose of this paper is to make a pioneering contribution in defining transparency movements.Design/methodology/approach – An exploratory approach has been used utilizing movement-specificprofessional and scholarly documents concerning 18 transparency movements.Findings – Different traditions, ideologies of openness and aspects involving connections betweenmovements have been identified as well as forms of organization.Originality/value – This is the first attempt at identifying and defining transparency movements as acontemporary phenomenon.

  • Thelin, Eric Peter
    et al.
    Univ Cambridge, Dept Clin Neurosci, Div Neurosurg, Cambridge Biomed Campus, Cambridge, England.;Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Helmy, Adel
    Univ Cambridge, Dept Clin Neurosci, Div Neurosurg, Cambridge Biomed Campus, Cambridge, England..
    Nelson, David W.
    Karolinska Inst, Sect Perioperat Med & Intens Care, Dept Physiol & Pharmacol, Stockholm, Sweden..
    Marklund, Niklas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Neurokirurgi. Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Neurosurg, Lund, Sweden..
    Editorial: Monitoring Pathophysiology in the injured Brain2018Inngår i: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 9, artikkel-id 193Artikkel i tidsskrift (Annet vitenskapelig)
  • Hagell, Peter
    et al.
    Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Högskolan Kristianstad, Forskningsplattformen för Hälsa i samverkan. Högskolan Kristianstad, Fakulteten för hälsovetenskap, Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap.
    Nilsson, Maria
    Lund University.
    Chaudhuri, Ray
    England.
    Odin, Per
    Lund University.
    The non-motor symptoms questionnaire and non-motor symptoms scale for use in Sweden2017Inngår i: Movement Disorders, 2017, Vol. 32, s. 74-74Konferansepaper (Annet vitenskapelig)
    Abstract [en]

    Objective: To translate the Non-Motor Symptoms Questionnaire (NMSQ) and the Non-Motor Symptoms Scale (NMSS) into Swedish, and test their linguistic validity and user-friendliness.

    Background: Non-motor symptoms (NMS) are common but under recognized among people with Parkinson’sdisease (PwPD). The NMSQ and NMSS were developed to ease NMS detection and assessment. The NMSQ is a patient-reported checklist regarding the presence of 30 NMS. The NMSS is a clinician-administered interview based rating scale regarding the frequency and severity of 30 NMS. Both are widely used, but Swedish versions have been lacking.

    Methods: The English NMSQ and NMSS were translated into Swedish in two stages. First, Swedish translations were produced by a professional translator and 3 bilingual PD-clinicians. Second, translations were reviewed by 3 independent PD-clinicians, resulting in minor revisions. The subsequent Swedish versions were then field-tested by 4 PD-clinicians on 5 PwPD each (n=20; 15 men; mean age and PD duration 67.6 and 9 years; HY stages II-IV). Evaluations included user burden (completion time), content relevance, and easiness to understand and use.

    Results: PwPD completed the NMSQ in a mean (range) of 4.8 (2-8) minutes. NMSQ content was considered relevant by 19 PwPD; 19 found instructions easy to understand and 17 found items easy to understand and respond to. The NMSS was completed in 13 (8-25) minutes. All 4 clinicians considered NMSS contents as relevant and instructions easy to understand; 1 considered items easy to rate. Two clinicians reported NMSS items as easy to understand for PwPD, and 1 clinician reported items as easy to answer for PwPD. Two clinicians considered theNMSS “very much” or “moderately”, and 2 considered it “a little” useful for clinical research. One clinician considered the NMSS “moderately”, and 3 considered it “a little” useful for clinical practice, but none would use it themselves. Translators, reviewers and field-test clinicians highlighted ambiguities with the NMSS not related to the translation.

    Conclusions: The NMSQ and NMSS were translated into Swedish and the linguistic validity of both translations was supported. There was also support for the user-friendliness of the NMSQ, but not for the NMSS. Issues detected with the NMSS do not appear to be specific for the Swedish version. Further evaluations of the NMSS in larger samples are needed.

  • Mohr, Sebastian
    et al.
    Karlstads universitet, Fakulteten för humaniora och samhällsvetenskap (from 2013), Centrum för genusforskning (from 2013).
    Hoeyer, Klaus
    University of Copenhagen.
    The Good Sperm Cell: Ethnographic Explorations of Semen Quality2018Inngår i: Tecnoscienza: Italian Journal of Science & Technology Studies, ISSN 2038-3460, E-ISSN 2038-3460, Vol. 9, nr 1, s. 9-28Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this article, we compare the meaning and assessment of semenquality across three different contexts: male infertility, sperm donation,and in-vitro sperm. We ask how semen quality is determined in thesethree contexts and what kind of practices and normative choices theseevaluative processes involve. While the notion of good semen quality is oftenreduced to biomedical evidence, our analysis shows that it also drawson beliefs about what is desirable and what is not, producing biomedical evidencein light of specifically desired outcomes. Unpacking semen quality, bylooking at the specificities of how it is done across three different contexts,in this article we thus move beyond comprehending quality standards aspurely technical matters and reposition biomedical assessments of male reproductivepotential in their political and normative contexts.

  • Mosleh, Marwan
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för hälsovetenskap.
    Dalal, Koustuv
    Örebro Univ, Örebro; Al Farabi Kazakh Natl Univ, Alma Ata, Kazakhstan.
    Aljeesh, Yousef
    Islamic Univ Gaza, Gaza Strip, Palestine.
    Svanström, Leif
    Karolinska Inst, Stockholm.
    The burden of war-injury in the Palestinian health care sector in Gaza Strip2018Inngår i: BMC International Health and Human Rights, ISSN 1472-698X, E-ISSN 1472-698X, Vol. 18, artikkel-id 28Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: War-related injury is a major public health concern, and a leading cause of mortality, morbidity, and disability globally, particularly in low and middle-income countries such as Palestine. Little is known about the burden of war-related injury in the Palestinian context. The objective of this study was to characterize the incidence and pattern of injuries, associated with war in Gaza Strip, from July 8 to August 26, 2014.

    Methods: This was a descriptive study based on an injury registry at hospital facilities in the Gaza Strip. A total of 420 victims records from 2014 Gaza war injuries were randomly selected, proportionate to the size of the study population estimated across five Gaza governorates. Simple descriptive statistics were calculated to explore the frequency and percentage distribution of study variables and injury data. A chi-square test (X-2) was used. The significance level was derived at p < 0.05. The data were analyzed by IBM SPSS software, version 23.

    Results: Males (75.5%) have experienced more war-related injuries than females (24.5%), constituting a male: female ratio of 3.1: 1. Almost half (49.5%) of the injured victims were of the age group 20-39, followed by children and adolescents (< 20 years), accounting for 31.4%. More than half of victims were single (53.6%), 44.3% were married and the rest were widowed or divorced. The overall number of injuries was 6.4 per 1000 population, though it varied among regions. North Gaza reported the highest number of injuries (9.0) and Rafah the lowest (4.7) per 1000 population. Blast and explosion were found to be the most common causes of war injuries (72.9%). The highest proportion of injuries were reported in the upper body. Multiple body shrapnel wounds and burns (39.3%) were most frequent. Other types of injuries were multiple organ injury (24.3%), fractures (13.6%), internal organ injury and bleeding (9.8%), amputation (4.5%), abrasions / lacerations and contusions (4.8%), vision or hearing loss or both (1.9%) and respiratory problems (1.9%). The highest percentage of injuries were classified as mild (46.9%), and the rest ranged from moderate-to-severe. Almost 26% of individuals had sustained disability, and most of them had physical/motor impairment.

    Conclusion: War-related injuries constitute a major problem to public health discipline and clinical medicine as well. A better surveillance system using ICD codes, and development of a comprehensive electronic data network are necessary to make future research easier and more timely.

  • McFarlane, S. Eryn
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi. Univ Edinburgh, Inst Evolutionary Biol, Edinburgh, Midlothian, Scotland.
    Ålund, Murielle
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Sirkiä, Paivi M.
    Univ Helsinki, Finnish Museum Nat Hist, Zool Unit, Helsinki, Finland; Univ Turku, Dept Biol, Sect Ecol, Turku, Finland.
    Qvarnström, Anna
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Difference in plasticity of resting metabolic rate - the proximate explanation to different niche breadth in sympatric Ficedula flycatchers2018Inngår i: Ecology and Evolution, ISSN 2045-7758, E-ISSN 2045-7758, Vol. 8, nr 9, s. 4575-4586Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Variation in relative fitness of competing recently formed species across heterogeneous environments promotes coexistence. However, the physiological traits mediating such variation in relative fitness have rarely been identified. Resting metabolic rate (RMR) is tightly associated with life history strategies, thermoregulation, diet use, and inhabited latitude and could therefore moderate differences in fitness responses to fluctuations in local environments, particularly when species have adapted to different climates in allopatry. We work in a long‐term study of collared (Ficedula albicollis) and pied flycatchers (Ficedula hypoleuca) in a recent hybrid zone located on the Swedish island of Öland in the Baltic Sea. Here, we explore whether differences in RMR match changes in relative performance of growing flycatcher nestlings across environmental conditions using an experimental approach. The fitness of pied flycatchers has previously been shown to be less sensitive to the mismatch between the peak in food abundance and nestling growth among late breeders. Here, we find that pied flycatcher nestlings have lower RMR in response to higher ambient temperatures (associated with low food availability). We also find that experimentally relaxed nestling competition is associated with an increased RMR in this species. In contrast, collared flycatcher nestlings did not vary their RMR in response to these environmental factors. Our results suggest that a more flexible nestling RMR in pied flycatchers is responsible for the better adaptation of pied flycatchers to the typical seasonal changes in food availability experienced in this hybrid zone. Generally, subtle physiological differences that have evolved when species were in allopatry may play an important role to patterns of competition, coexistence, or displacements between closely related species in secondary contact.

  • Hashemi, Esmatossadat
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för hälsovetenskap.
    Zangi, Mahdi
    Shahid Beheshti Univ Med Sci, Tehran, Iran.
    Sadeghi-Bazargani, Homayoun
    Tabriz Univ Med Sci, Tabriz, Iran.
    Soares, Joaquim
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för hälsovetenskap.
    Viitasara, Eija
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för hälsovetenskap.
    Mohammadi, Reza
    Karolinska Inst, Stockholm.
    Population-based epidemiology of non-fatal injuries in Tehran, Iran2018Inngår i: Health Promotion Perspectives, ISSN 2228-6497, Vol. 8, nr 2, s. 127-132Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Our aim in this survey was to explore descriptive epidemiology of injuries in Tehran in 2012 and to report the recalled estimates of injury incidence rates.

    Methods: A population survey was conducted in Tehran during 2012, within which a total of 8626 participants were enrolled. The cluster sampling was used to draw samples in 100 clusters with a pre-specified cluster size of 25 households per cluster. Data were collected on demographic features, accident and injury characteristics based on the International Classification of Diseases (ICD10).

    Results: A total of 618 injuries per 3 months were reported, within which 597 cases (96.6%)were unintentional injuries. More than 82% of all injuries were those caused by exposure to inanimate mechanical forces, traffic accidents, falls and burns. Above 80% of the traffic injuries happened among men (P<0.001). About 43% of the unintentional injuries were mild injuries.After the age of 40, women, unlike men, had higher risks for being injured. The estimated annual incidence rate for all types of injuries was 284.8 per 1000 (95% CI: 275.4-294.4) and for unintentional injuries was 275.2 per 1000.

    Conclusion: Injuries are major health problems in Tehran with a highly reported incidence. The status is not substantially improved over the recent years which urges the need to be adequately and emergently addressed. As the incidence rate was estimated based on participant recalls, the real incidence rate may even be higher than those reported in the current study.

  • Aaboud, M.
    et al.
    Univ Mohamed Premier, Fac Sci, Oujda, Morocco;LPTPM, Oujda, Morocco.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Brenner, Richard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael U.F.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Öhman, Henrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    Search for electroweak production of supersymmetric states in scenarios with compressed mass spectra at root s=13 TeV with the ATLAS detector2018Inngår i: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 97, nr 5, artikkel-id 052010Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A search for electroweak production of supersymmetric particles in scenarios with compressed mass spectra in final states with two low-momentum leptons and missing transverse momentum is presented. This search uses proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider in 2015-2016, corresponding to 36.1 tb(-1) of integrated luminosity at root s = 13 TeV. Events with same flavor pairs of electrons or muons with opposite electric charge are selected. The data are found to be consistent with the Standard Model prediction. Results are interpreted using simplified models of R-parity conserving supersymmetry in which there is a small mass difference between the masses of the produced supersymmetric particles and the lightest neutralino. Exclusion limits at 95% confidence level are set on next-to-lightest neutralino masses of up to 145 GeV for Higgsino production and 175 GeV for wino production, and slepton masses of up to 190 GeV for pair production of sleptons. In the compressed mass regime, the exclusion limits extend down to mass splittings of 2.5 GeV for Higgsino production, 2 GeV for wino production, and 1 GeV for slepton production. The results are also interpreted in the context of a radiatively-driven natural supersymmetry model with nonuniversal Higgs boson masses.

  • Quist, Johannes
    et al.
    Chalmers University of Technology.
    Bhadani, Kanishk
    Bengtsson, Magnus
    Chalmers University of Technology.
    Evertsson, Magnus
    Chalmers University of Technology.
    Malmqvist, Johan
    Chalmers University of Technology.
    Enelund, Mikael
    Chalmers University of Technology.
    Hoffenson, Steven
    CDIO Based Engineering Design and Optimization Course2017Inngår i: Proceedings of the 13th International CDIO Conference, University of Calgary, Calgary, Canada, June 18-22, 2017., 2017, s. 298-314Konferansepaper (Fagfellevurdert)
    Abstract [en]

    In order to design competitive products that meet today’s challenges, future engineers need knowledge and experience in applying and integrating optimization theory in the engineering design process. The Chalmers course Engineering Design and Optimization addresses this need and was developed and first offered in the fall semester of 2013. This paper provides a detailed account of the course development experiences, teaching methods and course evaluations using CDIO Standards. It also includes a discussion of the learning objectives, required resources, instructional processes and student assessments. The course is analyzed to see to what extent the course aim is satisfied and highlight areas of improvement. Three projects are carried out in groups of two students. The projects are a cantilever design-build-test exercise, a redesign project that involves material selection, and a multi disciplinary design project of an engine component using multi-physics software. The assignments are assessed with respect to both engineering criteria as well as reporting and communication. The course is believed to be novel in the way optimization theory and tools are taught as an integrated learning experience with engineering design and physical prototyping. The course has had a great impact on the students’ choice of master’s thesis project. The number of optimization-focused master thesis projects has increased from two or three to around 15 annually. Several of these projects are multidisciplinary and joint projects between departments of Applied Mechanics and Product & Production Development. The course has also initiated a valuable partnership with industry on optimization that now has grown to a network with 20 industrial and academic members.

  • Sjödahl Hammarlund, Catharina
    et al.
    Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Lund University.
    Westergren, Albert
    Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Högskolan Kristianstad, Forskningsplattformen för Hälsa i samverkan. Högskolan Kristianstad, Fakulteten för hälsovetenskap, Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap.
    Åström, Ingrid
    Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education.
    Edberg, Anna-Karin
    Högskolan Kristianstad, Forskningsplattformen för Hälsa i samverkan. Högskolan Kristianstad, Fakulteten för hälsovetenskap, Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap.
    Hagell, Peter
    Högskolan Kristianstad, Fakulteten för hälsovetenskap, Forskningsmiljön PRO-CARE, Patient Reported Outcomes - Clinical Assessment Research and Education. Högskolan Kristianstad, Forskningsplattformen för Hälsa i samverkan. Högskolan Kristianstad, Fakulteten för hälsovetenskap, Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap.
    The Impact of Living with Parkinson’s Disease: Balancing within a Web of Needs and Demands2018Inngår i: Parkinson's Disease, ISSN 2090-8083, E-ISSN 2042-0080, Vol. 2018, artikkel-id 4598651Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This study explores the impact of living with Parkinson’s disease (PD). Nineteen persons (11 women) aged 55–84 diagnosed with PD 3–27 years ago participated. Data were collected through semistructured interviews, which were recorded, transcribed verbatim, and analysed by qualitative content analysis. Four categories represented the impact of living with PD: “Changed prerequisites for managing day-to-day demands,” “Loss of identity and dignity,” “Compromised social participation,” and “The use of practical and psychological strategies.” There was a shift from an internal to an external locus of control in managing, control, competence, relatedness, and autonomy. According to self-determination theory, a shift towards extrinsically motivated behaviours may occur when these basic needs are thwarted, leading to compensatory strategies or needs substitutes with negative consequences on health and well-being. We suggest a needs-based approach as an important starting point to better understand the consequences of living with PD and to explore the means for people with PD to acquire an improved quality of life on their own terms. In conclusion, our findings suggest for a shift in focus, from a biomedical to a needs-based approach to understand the impact of living with PD and facilitate more person-centred care and person-centred outcome measurement.

  • Laaksonen, L.
    et al.
    Kallioinen, M.
    Löngsjö, J.
    Laitio, T.
    Scheinin, A.
    Scheinin, J.
    Kaisti, K.
    Maksimow, A.
    Kallionpää, R. E.
    Rajala, V.
    Johansson, Jarkko
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper. Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
    Kantonen, O.
    Nyman, M.
    Sirén, S.
    Valli, K.
    Revonsuo, A.
    Solin, O.
    Vahlberg, T.
    Alkire, M.
    Scheinin, H.
    Comparative effects of dexmedetomidine, propofol, sevoflurane, and S-ketamine on regional cerebral glucose metabolism in humans: a positron emission tomography study2018Inngår i: British Journal of Anaesthesia, ISSN 0007-0912, E-ISSN 1471-6771, Vol. 121, nr 1, s. 281-290Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction: The highly selective α2-agonist dexmedetomidine has become a popular sedative for neurointensive care patients. However, earlier studies have raised concern that dexmedetomidine might reduce cerebral blood flow without a concomitant decrease in metabolism. Here, we compared the effects of dexmedetomidine on the regional cerebral metabolic rate of glucose (CMRglu) with three commonly used anaesthetic drugs at equi-sedative doses.

    Methods: One hundred and sixty healthy male subjects were randomised to EC50 for verbal command of dexmedetomidine (1.5 ng ml-1; n=40), propofol (1.7 μg ml-1; n=40), sevoflurane (0.9% end-tidal; n=40) or S-ketamine (0.75 μg ml−1; n=20) or placebo (n=20). Anaesthetics were administered using target-controlled infusion or vapouriser with end-tidal monitoring. 18F-labelled fluorodeoxyglucose was administered 20 min after commencement of anaesthetic administration, and high-resolution positron emission tomography with arterial blood activity samples was used to quantify absolute CMRglu for whole brain and 15 brain regions.

    Results: At the time of [F18]fluorodeoxyglucose injection, 55% of dexmedetomidine, 45% of propofol, 85% of sevoflurane, 45% of S-ketamine, and 0% of placebo subjects were unresponsive. Whole brain CMRglu was 63%, 71%, 71%, and 96% of placebo in the dexmedetomidine, propofol, sevoflurane, and S-ketamine groups, respectively (P<0.001 between the groups). The lowest CMRglu was observed in nearly all brain regions with dexmedetomidine (P<0.05 compared with all other groups). With S-ketamine, CMRglu did not differ from placebo.

    Conclusions: At equi-sedative doses in humans, potency in reducing CMRglu was dexmedetomidine>propofol>ketamine=placebo. These findings alleviate concerns for dexmedetomidine-induced vasoconstriction and cerebral ischaemia.

  • Saati, Abrak
    Umeå universitet, Samhällsvetenskapliga fakulteten, Statsvetenskapliga institutionen. 1982.
    Negotiating the Post-Revolution Constitution for Tunisia – Members of the National Constituent Assembly Share Their Experiences2018Inngår i: International Law Research, ISSN 1927-5234, Vol. 7, nr 1, s. 235-246Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Though the Tunisian transition to democracy faces challenges seven years following the 2011 revolution and four years following the enactment of the new constitution, the country still constitutes a ‘success story’, especially in comparison to neighbouring states that were also touched by the Arab Uprisings. This paper takes an interest in exploring the Tunisian constitution-making process, and especially the political elite negotiated compromises that took place in the National Constituent Assembly. How were Tunisian religious and secular political forces able to unite and compromise on a constitutional document; what motivated their actions during the constitutional talks? Ideologies, rational pragmatism, self-serving interests or something else? This is a pertinent question that has bearing for other states that are in transition from authoritarian rule, in which religious and secular political parties are struggling to draft the political rules of the game anew. This is a qualitative study, based on interviews with political representatives, from a broad range of Tunisian political parties, who were part of the constitutional negotiations. Their responses suggest that pragmatism and rationality took precedence over ideological positions during the negotiations, and that this was indispensable for a draft to be produced. Despite this, the study argues that ideologies were likely not irrelevant in the minds of the political elites who were negotiating the post-revolution constitution, and that previous agreements and discussions among these elites that were, in fact, based on ideological positions, facilitated the constitutional negotiations that took place in the aftermath of the ousting of Ben-Ali

  • Bonde, Ingrid
    et al.
    Karin, Bäckstrand
    Katarina, Eckerberg
    Johan, Kyulenstierna
    Thomas, Kåberger
    Eva, Löfgren
    Markku, Rummukainen
    Sörlin, Sverker
    Filosofi och historia, KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Filosofi och teknikhistoria, Historiska studier av teknik, vetenskap och miljö.
    Det klimatpolitiska ramverket 20182018Rapport (Annet vitenskapelig)
  • Monrat, Ahmed Afif
    et al.
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Datavetenskap.
    Islam, Raihan Ul
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Datavetenskap.
    Hossain, Mohammad Shahadat
    University of Chittagong, Bangladesh.
    Andersson, Karl
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Datavetenskap.
    A Belief Rule Based Flood Risk Assessment Expert System using Real Time Sensor Data Streaming2018Inngår i: Proveedings of the 43nd IEEE Conference on Local Computer Networks Workshops (LCN Workshops), IEEE Computer Society, 2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Among the various natural calamities, flood is considered one of the most catastrophic natural hazards, which has a significant impact on the socio-economic lifeline of a country. The Assessment of flood risks facilitates taking appropriate measures to reduce the consequences of flooding. The flood risk assessment requires Big data which are coming from different sources, such as sensors, social media, and organizations. However, these data sources contain various types of uncertainties because of the presence of incomplete and inaccurate information. This paper presents a Belief rule-based expert system (BRBES) which is developed in Big data platform to assess flood risk in real time. The system processes extremely large dataset by integrating BRBES with Apache Spark while a web-based interface has developed allowing the visualization of flood risk in real time. Since the integrated BRBES employs knowledge driven learning mechanism, it has been compared with other data-driven learning mechanisms to determine the reliability in assessing flood risk. The integrated BRBES produces reliable results in comparison to other data-driven approaches. Data for the expert system has been collected by considering different case study areas of Bangladesh to validate the system.

  • Abedin, Md. Zainal
    et al.
    University of Science and Technology, Chittagong.
    Siddiquee, Kazy Noor E Alam
    University of Science and Technology Chittagong.
    Bhuyan, M. S.
    University of Science & Technology Chittagong.
    Karim, Razuan
    University of Science and Technology Chittagong.
    Hossain, Mohammad Shahadat
    University of Chittagong, Bangladesh.
    Andersson, Karl
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Datavetenskap.
    Performance Analysis of Anomaly Based Network Intrusion Detection Systems2018Inngår i: Proveedings of the 43nd IEEE Conference on Local Computer Networks Workshops (LCN Workshops), IEEE Computer Society, 2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Because of the increased popularity and fast expansion of the Internet as well as Internet of things, networks are growing rapidly in every corner of the society. As a result, huge amount of data is travelling across the computer networks that lead to the vulnerability of data integrity, confidentiality and reliability. So, network security is a burning issue to keep the integrity of systems and data. The traditional security guards such as firewalls with access control lists are not anymore enough to secure systems. To address the drawbacks of traditional Intrusion Detection Systems (IDSs), artificial intelligence and machine learning based models open up new opportunity to classify abnormal traffic as anomaly with a self-learning capability. Many supervised learning models have been adopted to detect anomaly from networks traffic. In quest to select a good learning model in terms of precision, recall, area under receiver operating curve, accuracy, F-score and model built time, this paper illustrates the performance comparison between Naïve Bayes, Multilayer Perceptron, J48, Naïve Bayes Tree, and Random Forest classification models. These models are trained and tested on three subsets of features derived from the original benchmark network intrusion detection dataset, NSL-KDD. The three subsets are derived by applying different attributes evaluator’s algorithms. The simulation is carried out by using the WEKA data mining tool.

  • Zhohov, Roman
    et al.
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Datavetenskap.
    Minovski, Dimitar
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Datavetenskap. InfoVista Sweden.
    Johansson, Per
    InfoVista Sweden.
    Andersson, Karl
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Datavetenskap.
    Real-time Performance Evaluation of LTE for IIoT2018Inngår i: Proceedings of the 43rd IEEE Conference on Local Computer Networks (LCN) / [ed] Soumaya Cherkaoui, Institute of Electrical and Electronics Engineers (IEEE), 2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Industrial Internet of Things (IIoT) is claimed to be a global booster technology for economic development. IIoT brings bulky use-cases with a simple goal of enabling automation, autonomation or just plain digitalization of industrial processes. The abundance of interconnected IoT and CPS generate additional burden on the telecommunication networks, imposing number of challenges to satisfy the key performance requirements. In particular, the QoS metrics related to real-time data exchange for critical machine-to-machine type communication. This paper analyzes a real-world example of IIoT from a QoS perspective, such as remotely operated underground mining vehicle. As part of the performance evaluation, a software tool is developed for estimating the absolute, one-way delay in end-toend transmissions. The measured metric is passed to a machine learning model for one-way delay prediction based on LTE RAN measurements using a commercially available cutting-edge software tool. The achieved results prove the possibility to predict the delay figures using machine learning model with a coefficient of determination up to 90%.

  • Hannes, Dave
    et al.
    Kiwa Inspecta Technology, Sweden.
    Svensson, Thomas
    TS Ingenjörsstatistik, Sweden.
    Anderson, Andreas
    RISE - Research Institutes of Sweden, Säkerhet och transport, Elektronik.
    Dahlberg, Magnus
    Kiwa Inspecta Technology, Sweden.
    Experimental study of weld fatigue strength reduction for a stainless steel piping component2018Inngår i: Procedia Engineering, 2018, s. 383-391Konferansepaper (Fagfellevurdert)
    Abstract [en]

    An experimental mean curve and a design fatigue curve corresponding to 95% survival probability were derived from realistic fatigue experiments on a non-welded water pressurized piping component with primarily focus on high cycle fatigue. The components were subjected to a synthetic variable amplitude bending deformation. Comparison with the results obtained for a similar piping component with a circumferential butt weld allowed the determination of an experimental fatigue strength reduction factor. Comparison with the fatigue procedure and design curve in ASME BPVC Section III allowed to quantify its conservatism with regards to accounting for the presence of a weldment and more generally transferability. © 2017 The Authors.

  • Rosengren, Annette ()
    Nordiska museet.
    Westergren, Christina ()
    Nordiska museet.
    Amatörfotografernas värld: Nordiska museets och Skansens årsbok 20092009Bok (Annet vitenskapelig)
  • Elmquist, Lennart
    et al.
    RISE - Research Institutes of Sweden, Swerea, Swerea SWECAST AB.
    Carlsson, Raul
    RISE - Research Institutes of Sweden, Swerea, Swerea SWECAST AB.
    Johansson, Christer
    RISE - Research Institutes of Sweden, ICT, Acreo.
    Cast iron components with intelligence2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    The paper describes a project with the aim to develop communicating and functional cast iron components in smart systems. The concept is based on sensors integrated into cast iron components; this will influence not only the component but also the casting process. Among the technical challenges is how to choose a sensor solution that cost-efficiently and with minimal environmental impact can be integrated into the component during the casting process, and especially without being damaged during mold filling and the high pouring temperature. Another challenge is how the iron will interact and interfere with sensor signals and whether an insulating intermediate material is needed or not. Integrating the sensors into the casting makes sensors a natural part of the component, which in turn can lead to more resource efficient designs, increased value added for the casting sector, and a general access to different possibilities of digitalization. The integrated sensors can be used for effective control and monitoring of components when in service and give information about for example how the component is used and what conditions it is exposed to. In other words, the component can tell when maintenance is needed or in worst cases, indicate that something is wrong before a failure will happen. Important measurands can e.g. be elongation, shear, temperature and vibration. Different combinations of sensor materials and insulating materials and their interaction with the cast iron have been investigated. It is shown how the interaction at the interface affects the microstructure and consequently the properties of the cast iron. In the case of insulating materials it is e.g. shown how air gaps are formed and in the case of sensor materials it is shown how a diffusion zone is formed and how this zone depends on the sensor material. How this diffusion zone affects the microstructure is discussed.

  • Aaboud, M.
    et al.
    Univ Mohamed Premier, Fac Sci, Oujda, Morocco;LPTPM, Oujda, Morocco.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik. Georg August Univ, Phys Inst 2, Gottingen, Germany.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max F.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael U.F.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Öhman, Henrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Rangel Smith, Camila
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    A search for pair-produced resonances in four-jet final states at root s=13 TeV with the ATLAS detector2018Inngår i: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 78, nr 3, artikkel-id 250Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A search for massive coloured resonances which are pair-produced and decay into two jets is presented. The analysis uses 36.7 fb(-1) of root s = 13 TeV pp collision data recorded by the ATLAS experiment at the LHC in 2015 and 2016. No significant deviation from the background prediction is observed. Results are interpreted in a SUSY simplified model where the lightest supersymmetric particle is the top squark, (t) over tilde, which decays promptly into two quarks through R-parity-violating couplings. Top squarks with masses in the range 100 GeV < m((T) over tilde) < 410 GeV are excluded at 95% confidence level. If the decay is into a b-quark and a light quark, a dedicated selection requiring two b-tags is used to exclude masses in the ranges 100 GeV < m((t) over tilde) < 470 GeV and 480 GeV < m(<(t)over tilde>) < 610 GeV. Additional limits are set on the pair-production of massive colour-octet resonances.

  • de la Ossa, Xenia
    et al.
    Univ Oxford, Math Inst, Andrew Wiles Bldg,Woodstock Rd, Oxford OX2 6GG, England.
    Larfors, Magdalena
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk fysik.
    Svanes, Eirik E.
    Sorbonne Univ, UPMC Paris 06, LPTHE, UMR 7589, F-75005 Paris, France;Sorbonne Univ, Inst Lagrange Paris, 98 Bis Bd Arago, F-75014 Paris, France.
    The Infinitesimal Moduli Space of Heterotic G2 Systems2018Inngår i: Communications in Mathematical Physics, ISSN 0010-3616, E-ISSN 1432-0916, Vol. 360, nr 2, s. 727-775Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Heterotic string compactifications on integrable G(2) structure manifolds Y with instanton bundles (V, A), (TY, (theta) over tilde )yield supersymmetric three-dimensional vacua that are of interest in physics. In this paper, we define a covariant exterior derivative D and show that it is equivalent to a heterotic G(2) system encoding the geometry of the heterotic string compactifications. This operator D acts on a bundle Q = T*Y circle plus End (V) circle plus End (TY) and satisfies a nilpotency condition (sic)(2) = 0, for an appropriate projection of D. Furthermore, we determine the infinitesimal moduli space of these systems and show that it corresponds to the finite-dimensional cohomology group (sic)(1)((sic)) (Q). We comment on the similarities and differences of our result with Atiyah's well-known analysis of deformations of holmorphic vector bundles over complex manifolds. Our analysis leads to results that are of relevance to all orders in the alpha' expansion.