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  • Parigi, Sara M.
    et al.
    Karolinska Institute, Sweden; University Hospital, Sweden.
    Czarnewski, Paulo
    Karolinska Institute, Sweden; University Hospital, Sweden.
    Das, Srustidhar
    Karolinska Institute, Sweden; University Hospital, Sweden.
    Steeg, Christiane
    Bernhard Nocht Institute Trop Med, Germany.
    Brockmann, Leonie
    9 Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Fernandez-Gaitero, Sara
    Karolinska Institute, Sweden; University Hospital, Sweden.
    Yman, Victor
    University Hospital, Sweden; Karolinska Institute, Sweden.
    Forkel, Marianne
    Karolinska Institute, Sweden.
    Höög, Charlotte
    Unit for Inflammation, Gastroenterology and Rheumathology, Department of Medicine, Huddinge, Sweden.
    Mjösberg, Jenny
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Karolinska Institute, Sweden.
    Westerberg, Lisa
    Karolinska Institute, Sweden.
    Färnert, Anna
    University Hospital, Sweden; Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
    Huber, Samuel
    University of Medical Centre Hamburg Eppendorf, Germany.
    Jacobs, Thomas
    Bernhard Nocht Institute Trop Med, Germany.
    Villablanca, Eduardo J.
    Karolinska Institute, Sweden; University Hospital, Sweden.
    Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 154Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A common helper-like innate lymphoid precursor (CHILP) restricted to the innate lymphoid cells (ILC) lineage has been recently characterized. While specific requirements of transcription factors for CHILPs development has been partially described, their ability to sense cytokines and react to peripheral inflammation remains unaddressed. Here, we found that systemic increase in Flt3L levels correlated with the expansion of Lineage (Lin)(neg)alpha 4 beta 7(+) precursors in the adult murine bone marrow. Expanded Lin(neg)alpha 4 beta 7(+) precursors were bona fide CHILPs as seen by their ability to differentiate into all helper ILCs subsets but cNK in vivo. Interestingly, Flt3L-expanded CHILPs transferred into lymphopenic mice preferentially reconstituted the small intestine. While we did not observe changes in serum Flt3L during DSS-induced colitis in mice or plasma from inflammatory bowel disease (IBD) patients, elevated Flt3L levels were detected in acute malaria patients. Interestingly, while CHILP numbers were stable during the course of DSS-induced colitis, they expanded following increased serum Flt3L levels in malaria-infected mice, hence suggesting a role of the Flt3L-ILC axis in malaria. Collectively, our results indicate that Flt3L expands CHILPs in the bone marrow, which might be associated with specific inflammatory conditions.

  • Teodoro, Douglas
    et al.
    University of Estado Rio de Janeiro, Brazil; Swiss Institute Bioinformat, Switzerland; HEG Geneva, Switzerland.
    Sundvall, Erik
    Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten.
    Joao Junior, Mario
    University of Estado Rio de Janeiro, Brazil.
    Ruch, Patrick
    Swiss Institute Bioinformat, Switzerland; HEG Geneva, Switzerland.
    Miranda Freire, Sergio
    University of Estado Rio de Janeiro, Brazil.
    ORBDA: An &ITopen&ITEHR benchmark dataset for performance assessment of electronic health record servers2018Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 1, artikkel-id e0190028Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The openEHR specifications are designed to support implementation of flexible and interoperable Electronic Health Record (EHR) systems. Despite the increasing number of solutions based on the openEHR specifications, it is difficult to find publicly available healthcare datasets in the openEHR format that can be used to test, compare and validate different data persistence mechanisms for openEHR. To foster research on openEHR servers, we present the openEHR Benchmark Dataset, ORBDA, a very large healthcare benchmark dataset encoded using the openEHR formalism. To construct ORBDA, we extracted and cleaned a de-identified dataset from the Brazilian National Healthcare System (SUS) containing hospitalisation and high complexity procedures information and formalised it using a set of openEHR archetypes and templates. Then, we implemented a tool to enrich the raw relational data and convert it into the openEHR model using the openEHR Java reference model library. The ORBDA dataset is available in composition, versioned composition and EHR openEHR representations in XML and JSON formats. In total, the dataset contains more than 150 million composition records. We describe the dataset and provide means to access it. Additionally, we demonstrate the usage of ORBDA for evaluating inserting throughput and query latency performances of some NoSQL database management systems. We believe that ORBDA is a valuable asset for assessing storage models for openEHR-based information systems during the software engineering process. It may also be a suitable component in future standardised benchmarking of available openEHR storage platforms.

  • Salari, Sajjad
    et al.
    Linköpings universitet, Medicinska fakulteten. Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi.
    Silverå Ejneby, Malin
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelning för neurobiologi. Linköpings universitet, Medicinska fakulteten.
    Brask, Johan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelning för neurobiologi. Linköpings universitet, Medicinska fakulteten.
    Elinder, Fredrik
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelning för neurobiologi. Linköpings universitet, Medicinska fakulteten.
    Isopimaric acid - a multi-targeting ion channel modulator reducing excitability and arrhythmicity in a spontaneously beating mouse atrial cell line2018Inngår i: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 222, nr 1, artikkel-id e12895Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    AimAtrial fibrillation is the most common persistent cardiac arrhythmia, and it is not well controlled by present drugs. Because some resin acids open voltage-gated potassium channels and reduce neuronal excitability, we explored the effects of the resin acid isopimaric acid (IPA) on action potentials and ion currents in cardiomyocytes. MethodsSpontaneously beating mouse atrial HL-1 cells were investigated with the whole-cell patch-clamp technique. Results1-25 mol L-1 IPA reduced the action potential frequency by up to 50%. The effect of IPA on six different voltage-gated ion channels was investigated; most voltage-dependent parameters of ion channel gating were shifted in the negative direction along the voltage axis, consistent with a hypothesis that a lipophilic and negatively charged compound binds to the lipid membrane close to the positively charged voltage sensor of the ion channels. The major finding was that IPA inactivated sodium channels and L- and T-type calcium channels and activated the rapidly activating potassium channel and the transient outward potassium channel. Computer simulations of IPA effects on all of the ion currents were consistent with a reduced excitability, and they also showed that effects on the Na channel played the largest role to reduce the action potential frequency. Finally, induced arrhythmia in the HL-1 cells was reversed by IPA. ConclusionLow concentrations of IPA reduced the action potential frequency and restored regular firing by altering the voltage dependencies of several voltage-gated ion channels. These findings can form the basis for a new pharmacological strategy to treat atrial fibrillation.

  • Noren, Elisabeth
    et al.
    Karolinska Institute, Sweden; Regional Jönköping County, Sweden.
    Mellander, Marie-Rose
    Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
    Almer, Sven
    Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
    Söderman, Jan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten. Regional Jonköping County, Sweden.
    Genetic Variation and Gene Expression Levels of Tight Junction Genes Indicates Relationships Between PTEN as well as MAGI1 and Microscopic Colitis2018Inngår i: Digestive Diseases and Sciences, ISSN 0163-2116, E-ISSN 1573-2568, Vol. 63, nr 1, s. 105-112Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Microscopic colitis (MC) has been associated with increased paracellular permeability. Therefore, we aimed to investigate potential associations between MC and several genes encoding tight junction (TJ) proteins reported to interact with each other. The association between MC and single nucleotide polymorphisms (SNP; n = 63) within TJ genes (F11R, MAGI1, MAGI2, MAGI3, PARD3, PTEN, and TJP1) were investigated in a case-control study (n (MC patients) = 104 and n (controls) = 423). The genes that exhibited an association with MC were further investigated for gene expression related to genotype, MC phenotype, and gender using colonic biopsies from MC patients (n = 25) and controls (n = 58). Based on the number of investigated genes and after correction for multiple testing, an association was detected between a SNP marker in PTEN (rs1234224) and both MC overall (OR = 1.70, 95% CI 1.23-2.34, p = 0.001) and collagenous colitis (CC; OR = 1.79, 95% CI 1.22-2.62, p = 0.003). Further, SNP markers in MAGI1 (rs17417230) and F11R (rs790055) were associated with MC overall (OR = 1.58, 95% CI 1.14-2.19, p = 0.006) and with CC (OR = 2.58, 95% CI 1.27-5.25, p = 0.007), respectively. However, none of the associated SNPs contributed markedly to the expression of the respective genes. Nonetheless, decreased MAGI1 (p = 3.47 x 10(-4)) and PTEN (p = 0.004) expression was associated with lymphocytic colitis (LC) and CC, respectively, compared to controls. Decreased expression of PTEN and MAGI1 in the colonic mucosa might contribute to the pathogenesis of MC and its sub-phenotypes. Furthermore, our study indicates that genetic variants of TJ components are predisposing factors in the etiology of MC. Finally, F11R, MAGI1, and PTEN are new candidate genes that exhibit an association with MC.

  • Palm, Jenny
    et al.
    Linköpings universitet, Institutionen för tema, Tema teknik och social förändring. Linköpings universitet, Filosofiska fakulteten. Lund University, Sweden.
    Reindl, Katharina
    Linköpings universitet, Institutionen för tema, Tema teknik och social förändring. Linköpings universitet, Filosofiska fakulteten.
    Understanding barriers to energy-efficiency renovations of multifamily dwellings2018Inngår i: Energy Efficiency, ISSN 1570-646X, E-ISSN 1570-6478, Vol. 11, nr 1, s. 53-65Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We have studied how energy efficiency is discussed by professionals during renovation of multifamily dwellings, in order to capture how barriers in relation to energy measures are appearing, disappearing and transformed during the process. We did participatory observations of renovation meetings, conducted interviews with the involved professionals and studied-related documents. Our intentions have not been to assess decisions made, but to follow the process to gain a different understanding of how barriers can be understood during renovations. We can conclude that the renovation process is based on a complex series of contractural relationships, where assymetric information and lack of common goals contribute to split incentives. The results also show that the housing companys internal organisation becomes a barrier where assymetric information and split incentives also became an in-house barrier. The decisions were often based on bounded rationality where calculations were surprisingly absent in meetings and during discussions on energy measures.

  • Alabas, Oras A.
    et al.
    University of Leeds, England.
    Gale, Chris P.
    University of Leeds, England; York Teaching Hospital NHS Fdn Trust, England.
    Hall, Marlous
    University of Leeds, England.
    Rutherford, Mark J.
    University of Leicester, England.
    Szummer, Karolina
    Department Med, Sweden.
    Lawesson, Sofia
    Linköpings universitet, Institutionen för medicin och hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Kardiologiska kliniken US.
    Alfredsson, Joakim
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Kardiologiska kliniken US.
    Lindahl, Bertil
    Uppsala University, Sweden; Uppsala University, Sweden.
    Jernberg, Tomas
    Karolinska Institute, Sweden.
    Sex Differences in Treatments, Relative Survival, and Excess Mortality Following Acute Myocardial Infarction: National Cohort Study Using the SWEDEHEART Registry2017Inngår i: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, ISSN 2047-9980, E-ISSN 2047-9980, Vol. 6, nr 12, artikkel-id e007123Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background-This study assessed sex differences in treatments, all-cause mortality, relative survival, and excess mortality following acute myocardial infarction. Methods and Results-A population-based cohort of all hospitals providing acute myocardial infarction care in Sweden (SWEDEHEART [Swedish Web System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies]) from 2003 to 2013 was included in the analysis. Excess mortality rate ratios (EMRRs), adjusted for clinical characteristics and guideline-indicated treatments after matching by age, sex, and year to background mortality data, were estimated. Although there were no sex differences in all-cause mortality adjusted for age, year of hospitalization, and comorbidities for ST-segment-elevation myocardial infarction (STEMI) and non-STEMI at 1 year (mortality rate ratio: 1.01 [95% confidence interval (CI), 0.96-1.05] and 0.97 [95% CI, 0.95-.99], respectively) and 5 years (mortality rate ratio: 1.03 [95% CI, 0.99-1.07] and 0.97 [95% CI, 0.95-.99], respectively), excess mortality was higher among women compared with men for STEMI and non-STEMI at 1 year (EMRR: 1.89 [95% CI, 1.66-2.16] and 1.20 [95% CI, 1.16-1.24], respectively) and 5 years (EMRR: 1.60 [95% CI, 1.48-1.72] and 1.26 [95% CI, 1.21-1.32], respectively). After further adjustment for the use of guideline-indicated treatments, excess mortality among women with non-STEMI was not significant at 1 year (EMRR: 1.01 [95% CI, 0.97-1.04]) and slightly higher at 5 years (EMRR: 1.07 [95% CI, 1.02-1.12]). For STEMI, adjustment for treatments attenuated the excess mortality for women at 1 year (EMRR: 1.43 [95% CI, 1.26-1.62]) and 5 years (EMRR: 1.31 [95% CI, 1.19-1.43]). Conclusions-Women with acute myocardial infarction did not have statistically different all-cause mortality, but had higher excess mortality compared with men that was attenuated after adjustment for the use of guideline-indicated treatments. This suggests that improved adherence to guideline recommendations for the treatment of acute myocardial infarction may reduce premature cardiovascular death among women.

  • Tham, Henrik
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Kriminologiska institutionen.
    Thomas Mathiesen, Cadenza. A Professional Autobiography. London: EG Press Limited. 20172017Inngår i: Nordisk Tidsskrift for Kriminalvidenskab, ISSN 0029-1528, Vol. 104, nr 3, s. 348-352Artikkel, omtale (Annet vitenskapelig)
  • Lundberg, Mary
    Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, Industriellt och hållbart byggande.
    Plattformsorganisation av renoveringsprocesser2017Rapport (Annet vitenskapelig)
    Abstract [en]

    There is a need to refurbish the Million Homes programme in Sweden. Many of the housing complexes belonging to the Million Homes programme consist of a numerous of similar apartments. To learn from previous refurbishment projects a method for knowledge management to facilitate organizational learning would be useful. In new build, one method for managing knowledge is to use a platform concept. Applying a platform concept is understood as organising a container of methods and information that can be reused between building projects. The platform consists of information about the components, the production processes, the supply chain, and the know-how. In refurbishment projects, the reuse of components is difficult due to the large variety of building solutions in the existing housing stock. Therefore, a platform for refurbishment needs to be built on reuse of production processes, supply chain and know-how. The platform thus represents a container for re-use of knowledge between building projects.The aim of this research is to contribute to the understanding and use of a platform as an effective mean to increase knowledge sharing and experience feedback, i.e. achieve increased learning between different refurbishment projects, and the permanent organization, for the benefit of organizational learning within a construction company.The introduction of a platform does not necessarily mean that people will share knowledge more than before, which raise a RQ I: What are some of the possible ways to increase knowledge sharing using a platform? RQ I was addressed by performing four semi-structured interviews with platform managers with the purpose to test and discuss Javernick-Will´s(2011) theory of the importance of social motivations for increased knowledge sharing. Further, the project-based focus in the construction industry and the mere fact that large proportions of the work carried out on a construction site is inherently action-oriented, practical, experience-based and performed according to rules of thumb, thus encompassing tacit knowledge, are complicating factors for the construction of a platform for refurbishment.This lead to the formulation of research question RQ II: What is important to consider when managing knowledge by the use of a platform to enhance learning in construction projects? RQ II was addressed in the second study and a proposition for a knowledge management method was tested and discussed by attending meetings in five on-going refurbishment projects acting as an observer. Insights from the second study indicate that applying a knowing in practice perspective and developing methods for communicating and collecting knowledge related to tacit knowledge is crucial for successful knowledge management.Hence, the purpose in study III: To identify methods used in the everyday practice in construction projects for the sharing and transfer of tacit knowledge. A systematic literature review addressed RQ III.

    Findings indicate that applying a knowing in practice perspective and adopting methods for communicating and collecting tacit knowledge and focusing on the individuals who actually will be sharing their knowledge and especially on their social motivations are important for successful knowledge management in construction projects. Also, managers and leaders should demonstrate knowledge sharing behaviours as this will facilitate the establishment of a culture where knowledge sharing is the norm. It is further suggested to use a combination of technical and social methods for managing knowledge in construction projects. In addition, methods such as e.g. formal processes, revisions, different kinds of face- to-face meetings, workshops, mentorships, and site visits involving different actors in a construction project are recognized as being especially useful for knowledge sharing and knowledge transfer where both tacit and explicit knowledge to some extent are embraced.In conclusion, applying an interorganizational focus regarding knowledge management, i.e. focus on communication, knowledge sharing and knowledge transfer also across organizational boundaries, including the tenants and sub-contractors, should be considered when refurbishing the Million Homes programme. Also, the adopted knowledge management methods should embrace tacit knowledge. Formal processes, revisions, different kinds of face- to-face meetings, workshops, mentorships, and site visits are recognized as especially useful per se. The adopted methods for knowledge sharing and knowledge transfer should acknowledge social motivations on the individual level to facilitate knowledge sharing. To constantly build the platform, the results from the knowledge management methods need to be captured while moving along through building projects. This is a task that needs allocation of resources and adequate methods for information capture. Considering the above, a platform concept for refurbishment of the Million Homes programme has the potential to function both as a vehicle for transfer of information and as a means for knowledge-driven development in an organization, i.e. a means for organizational learning within a construction company.

  • Yngve, Moa
    et al.
    Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, Avdelningen för arbetsterapi. Linköpings universitet, Medicinska fakulteten.
    Munkholm, Michaela
    Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, Avdelningen för arbetsterapi. Linköpings universitet, Medicinska fakulteten.
    Lidström, Helene
    Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, Avdelningen för arbetsterapi. Linköpings universitet, Medicinska fakulteten.
    Hemmingsson, Helena
    Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, Avdelningen för arbetsterapi. Linköpings universitet, Medicinska fakulteten.
    Ekbladh, Elin
    Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, Avdelningen för arbetsterapi. Linköpings universitet, Medicinska fakulteten.
    Validity of the school setting interview for students with special educational needs in regular high school - a Rasch analysis2018Inngår i: Health and Quality of Life Outcomes, ISSN 1477-7525, E-ISSN 1477-7525, Vol. 16, artikkel-id 12Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Participation in education is a vital component of adolescents everyday life and a determinant of health and future opportunities in adult life. The School Setting Interview (SSI) is an instrument which assesses student-environment fit and reflects the potential needs for adjustments to enhance students participation in school activities. The aim of the study was to investigate the psychometric properties of the SSI for students with special educational needs in regular high school. Methods: A sample of 509 students with special educational needs was assessed with the SSI. The polytomous unrestricted Rasch model was used to analyze the psychometric properties of the SSI regarding targeting, model fit, differential item functioning (DIF), response category functioning and unidimensionality. Results: The SSI generally confirmed fit to assumptions of the Rasch model. Reliability was acceptable (0.73) and the SSI scale was able to separate students into three different levels of student-environment fit. DIF among gender was detected in item "Remember things" and in item "Homework" DIF was detected among students with or without diagnosis. All items had disordered thresholds. The SSI demonstrated unidimensionality and no response dependence was present among items. Conclusion: The results suggest that the SSI is valid for use among students with special educational needs in order to provide and evaluate environmental adjustments. However, the items with the detected DIF and the SSI rating scale with its disordered thresholds needs to be further scrutinized.

  • Lin, Guangliang
    et al.
    School of Mathematics, Zhejiang University, Hangzhou, Zhejiang, China.
    Cheng, Xiaoliang
    aSchool of Mathematics, Zhejiang University, Hangzhou, Zhejiang, China.
    Zhang, Ye
    Örebro universitet, Institutionen för naturvetenskap och teknik. Faculty of Mathematics, Technische Universitat Chemnitz, Chemnitz, Germany.
    A parametric level set based collage method for an inverse problem in elliptic partial differential equations2018Inngår i: Journal of Computational and Applied Mathematics, ISSN 0377-0427, E-ISSN 1879-1778Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this work, based on the collage theorem, we develop a new numerical approach to reconstruct the locations of discontinuity of the conduction coefficient in elliptic partial differential equations (PDEs) with inaccurate measurement data and coefficient value. For a given conductivity coefficient, one can construct a contraction mapping such that its fixed point is just the gradient of a solution to the elliptic system. Therefore, the problem of reconstructing a conductivity coefficient in PDEs can be considered as an approximation of the observation data by the fixed point of a contraction mapping. By collage theorem, we translate it to seek a contraction mapping that keeps the observation data as close as possible to itself, which avoids solving adjoint problems when applying the gradient descent method to the corresponding optimization problem. Moreover, the total variation regularizing strategy is applied to tackle the ill-posedness and the parametric level set technique is adopted to represent the discontinuity of the conductivity coefficient. Various numerical simulations are given to show the efficiency of the proposed method.

  • Sörensson, Anna
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för ekonomivetenskap och juridik.
    Sustainability information from Swedish tourism companies - what, where and for whom?2017Inngår i: Proceedings of the 5th International Conference Innovation Management, Entrepreneurship and Sustainability, 2017Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Purpose: Within the tourism industry, there is a considerable focus on sustainable tourism. One way for tourismservice providers to address these issues and present their sustainability work is through annual reports,sustainability reports and homepages. Sustainability report is a way for tourism companies to be more legitimateand accountable toward their stakeholders. The research objective, with this study, was to investigate and analyzeSwedish tourism service providers’ sustainability information. What kind of sustainability information ispresented? Where is the sustainability information presented and for whom?

    Design/methodology/approach: The data for this study was collected mainly during December 2015-February2016. The research design was constructed as a qualitative explorative study on tourism companies and how theypresent their work with sustainability (economic, social and environmental) for their stakeholders. Data wascollected from 50 different tourism companies in Sweden from their annual reports, sustainability reports and theirhome pages. They are large-sized tourism companies with a yearly turnover between 5-50 million euros.

    Findings: The result shows that what they present is often focused on social or environmental sustainability (notboth dimensions). The tourism service providers are all presenting economic sustainability since they must do anannual report yearly. Another conclusion is that they do not use sustainability report as their communicationchannel to show accountability and legitimacy to their stakeholders. Home pages are used mostly for presentingtheir sustainability work despite that there are large differences between how much information from thecompanies. The stakeholders seem to be mainly the customers.

    Research/practical implications: It still seems like that many tourism companies do not see the benefits insustainable tourism. If tourism companies want to be legitimate and accountable concerning sustainability theyhave the possibility to present more information about their sustainable information to stakeholders and conducteven more efforts on sustainability issues in their everyday business life. It would be interesting to make interviewsto gain more insight in what they want to communicate to their stakeholders concerning their sustainability work.It would also be interesting to compare with other countries and culture concerning tourist companies’sustainability work and their communication to stakeholders.

    Originality/value: The main value of this paper is that the study focuses on large sized tourism companies thatmust present a sustainability report from 2017. The European Union has decided to make it mandatory for largesized companies to present sustainability reports in 2017 and this study is therefore interesting since it shows theirsustainability work before this law is implemented.

  • Bohlin, Katja Stenstrom
    et al.
    Ankardal, Maud
    Nüssler, Emil
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Obstetrik och gynekologi.
    Lindkvist, Håkan
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för matematik och matematisk statistik.
    Milsom, Ian
    Factors influencing the outcome of surgery for pelvic organ prolapse2018Inngår i: International Urogynecology Journal, ISSN 0937-3462, E-ISSN 1433-3023, Vol. 29, nr 1, s. 81-89Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Pelvic organ prolapse (POP) surgery is a common gynecological procedure. Our aim was to assess the influence of obesity and other risk factors on the outcome of anterior and posterior colporrhaphy with and without mesh. Data were retrieved from the Swedish National Register for Gynecological Surgery on 18,554 women undergoing primary and repeat POP surgery without concomitant urinary incontinence (UI) surgery between 2006 and 2015. Multivariate logistic regression analyses were used to identify independent risk factors for a sensation of a vaginal bulge, de novo UI, and residual UI 1 year after surgery. The overall subjective cure rate 1 year after surgery was 80% (with mesh 86.4% vs 77.3% without mesh, p < 0.001). The complication rate was low, but was more frequent in repeat surgery that were mainly mesh related. The use of mesh was also associated with more frequent de novo UI, but patient satisfaction and cure rates were higher compared with surgery without mesh. Preoperative sensation of a vaginal bulge, severe postoperative complications, anterior colporrhaphy, prior hysterectomy, postoperative infections, local anesthesia, and body mass index (BMI) 30 were risk factors for sensation of a vaginal bulge 1 year postsurgery. Obesity had no effect on complication rates but was associated increased urinary incontinence (UI) after primary surgery. Obesity had no influence on cure or voiding status in women undergoing repeat surgery. Obesity had an impact on the sensation of a vaginal bulge and the presence of UI after primary surgery but not on complications.

  • Alirezaie, Marjan
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Kiselev, Andrey
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Klügl, Franziska
    Örebro universitet, Institutionen för naturvetenskap och teknik. Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Längkvist, Martin
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Loutfi, Amy
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Exploiting Context and Semantics for UAV Path-finding in an Urban Setting2017Inngår i: Proceedings of the 1st International Workshop on Application of Semantic Web technologies in Robotics (AnSWeR 2017), Portoroz, Slovenia, May 29th, 2017 / [ed] Emanuele Bastianelli, Mathieu d'Aquin, Daniele Nardi, Technical University Aachen , 2017, s. 11-20Konferansepaper (Fagfellevurdert)
    Abstract [en]

    In this paper we propose an ontology pattern that represents paths in a geo-representation model to be used in an aerial path planning processes. This pattern provides semantics related to constraints (i.e., ight forbidden zones) in a path planning problem in order to generate collision free paths. Our proposed approach has been applied on an ontology containing geo-regions extracted from satellite imagery data from a large urban city as an illustrative example.

  • Popp, David
    et al.
    ASTAR, Inst Mol & Cell Biol, Biopolis, Singapore 138673, Singapore..
    Loh, N. Duane
    Natl Univ Singapore, Dept Phys, Singapore 117557, Singapore.;Natl Univ Singapore, Ctr BioImaging Sci, Singapore 117546, Singapore..
    Zorgati, Habiba
    ASTAR, Inst Mol & Cell Biol, Biopolis, Singapore 138673, Singapore.;Natl Univ Singapore, Dept Biochem, Singapore 117597, Singapore..
    Ghoshdastider, Umesh
    ASTAR, Inst Mol & Cell Biol, Biopolis, Singapore 138673, Singapore..
    Liow, Lu Ting
    Natl Univ Singapore, Dept Med, Singapore 119074, Singapore..
    Ivanova, Magdalena I.
    Univ Michigan, Dept Neurol, 109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA..
    Larsson, Mårten
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. ASTAR, Inst Mol & Cell Biol, Biopolis, Singapore 138673, Singapore.
    DePonte, Daniel P.
    SLAC Natl Accelerator Lab, Linac Coherent Light Source, 2575 Sand Hill Rd, Menlo Pk, CA 94025 USA..
    Bean, Richard
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.;European XFEL GmbH, D-22761 Hamburg, Germany..
    Beyerlein, Kenneth R.
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany..
    Gati, Cornelius
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany..
    Oberthuer, Dominik
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.;Univ Hamburg, Inst Biochem & Mol Biol, D-22607 Hamburg, Germany..
    Arnlund, David
    Univ Gothenburg, Dept Chem & Mol Biol, S-40530 Gothenburg, Sweden..
    Branden, Gisela
    Univ Gothenburg, Dept Chem & Mol Biol, S-40530 Gothenburg, Sweden..
    Berntsen, Peter
    Univ Gothenburg, Dept Chem & Mol Biol, S-40530 Gothenburg, Sweden..
    Cascio, Duilio
    Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA..
    Chavas, Leonard M. G.
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany..
    Chen, Joe P. J.
    Univ Canterbury, Computat Imaging Grp, Dept Elect & Comp Engn, Christchurch, New Zealand.;Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA..
    Ding, Ke
    ASTAR, Inst Mol & Cell Biol, Biopolis, Singapore 138673, Singapore..
    Fleckenstein, Holger
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany..
    Gumprecht, Lars
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany..
    Harimoorthy, Rajiv
    Univ Gothenburg, Dept Chem & Mol Biol, S-40530 Gothenburg, Sweden..
    Mossou, Estelle
    Inst Laue Langevin, F-38000 Grenoble, France.;Keele Univ, EPSAM ISTM, Keele ST5 5BG, Staffs, England..
    Sawaya, Michael R.
    Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA..
    Brewster, Aaron S.
    Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94720 USA..
    Hattne, Johan
    Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94720 USA.;Howard Hughes Med Inst, Janelia Res Campus,19700 Helix Dr, Ashburn, VA 20147 USA..
    Sauter, Nicholas K.
    Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94720 USA..
    Seibert, Marvin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Seuring, Carolin
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany..
    Stellato, Francesco
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany..
    Tilp, Thomas
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany..
    Eisenberg, David S.
    Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA..
    Messerschmidt, Marc
    SLAC Natl Accelerator Lab, Linac Coherent Light Source, 2575 Sand Hill Rd, Menlo Pk, CA 94025 USA..
    Williams, Garth J.
    SLAC Natl Accelerator Lab, Linac Coherent Light Source, 2575 Sand Hill Rd, Menlo Pk, CA 94025 USA..
    Koglin, Jason E.
    SLAC Natl Accelerator Lab, Linac Coherent Light Source, 2575 Sand Hill Rd, Menlo Pk, CA 94025 USA..
    Makowski, Lee
    Northeastern Univ, Dept Bioengn, 360 Huntington Ave, Boston, MA 02115 USA..
    Millane, Rick P.
    Univ Canterbury, Computat Imaging Grp, Dept Elect & Comp Engn, Christchurch, New Zealand..
    Forsyth, Trevor
    Inst Laue Langevin, F-38000 Grenoble, France.;Keele Univ, EPSAM ISTM, Keele ST5 5BG, Staffs, England..
    Boutet, Sebastien
    SLAC Natl Accelerator Lab, Linac Coherent Light Source, 2575 Sand Hill Rd, Menlo Pk, CA 94025 USA..
    White, Thomas A.
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany..
    Barty, Anton
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany..
    Chapman, Henry
    DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.;Univ Hamburg, Dept Phys, Luruper Chaussee 149, D-22607 Hamburg, Germany..
    Chen, Swaine L.
    Natl Univ Singapore, Dept Med, Singapore 119074, Singapore.;ASTAR, Biopolis, Genome Inst Singapore, Singapore 138672, Singapore..
    Liang, Mengning
    SLAC Natl Accelerator Lab, Linac Coherent Light Source, 2575 Sand Hill Rd, Menlo Pk, CA 94025 USA.;DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany..
    Neutze, Richard
    Univ Gothenburg, Dept Chem & Mol Biol, S-40530 Gothenburg, Sweden..
    Robinson, Robert C.
    ASTAR, Inst Mol & Cell Biol, Biopolis, Singapore 138673, Singapore.;Natl Univ Singapore, Dept Biochem, Singapore 117597, Singapore.;Okayama Univ, Res Inst Interdisciplinary Sci, Okayama 7008530, Japan..
    Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser2017Inngår i: CYTOSKELETON, ISSN 1949-3584, Vol. 74, nr 12, s. 472-481Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A major goal for X-ray free-electron laser (XFEL) based science is to elucidate structures of biological molecules without the need for crystals. Filament systems may provide some of the first single macromolecular structures elucidated by XFEL radiation, since they contain one-dimensional translational symmetry and thereby occupy the diffraction intensity region between the extremes of crystals and single molecules. Here, we demonstrate flow alignment of as few as 100 filaments (Escherichia coli pili, F-actin, and amyloid fibrils), which when intersected by femtosecond X-ray pulses result in diffraction patterns similar to those obtained from classical fiber diffraction studies. We also determine that F-actin can be flow-aligned to a disorientation of approximately 5 degrees. Using this XFEL-based technique, we determine that gelsolin amyloids are comprised of stacked -strands running perpendicular to the filament axis, and that a range of order from fibrillar to crystalline is discernable for individual -synuclein amyloids.

  • Guinea Diaz, Manuel
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Umeå Plant Science Centre (UPSC).
    Hernandez-Verdeja, Tamara
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Umeå Plant Science Centre (UPSC).
    Kremnev, Dmitry
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Umeå Plant Science Centre (UPSC).
    Crawford, Tim
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Umeå Plant Science Centre (UPSC).
    Dubreuil, Carole
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Umeå Plant Science Centre (UPSC).
    Strand, Åsa
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Umeå Plant Science Centre (UPSC).
    Redox regulation of PEP activity during seedling establishment in Arabidopsis thaliana2018Inngår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, artikkel-id 50Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Activation of the plastid-encoded RNA polymerase is tightly controlled and involves a network of phosphorylation and, as yet unidentified, thiol-mediated events. Here, we characterize PLASTID REDOX INSENSITIVE2, a redox-regulated protein required for full PEP-driven transcription. PRIN2 dimers can be reduced into the active monomeric form by thioredoxins through reduction of a disulfide bond. Exposure to light increases the ratio between the monomeric and dimeric forms of PRIN2. Complementation of prin2-2 with different PRIN2 protein variants demonstrates that the monomer is required for light-activated PEP-dependent transcription and that expression of the nuclear-encoded photosynthesis genes is linked to the activity of PEP. Activation of PEP during chloroplast development likely is the source of a retrograde signal that promotes nuclear LHCB expression. Thus, regulation of PRIN2 is the thiol-mediated mechanism required for full PEP activity, with PRIN2 monomerization via reduction by TRXs providing a mechanistic link between photosynthetic electron transport and activation of photosynthetic gene expression.

  • Löfling, Lukas
    et al.
    Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol, SE-17176 Stockholm, Sweden..
    Linder, Marie
    Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol, SE-17176 Stockholm, Sweden..
    Ekstrand, Charlotta
    Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol, SE-17176 Stockholm, Sweden..
    Cherif, Honar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Hematologi.
    Kieler, Helle
    Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol, SE-17176 Stockholm, Sweden..
    Bahmanyar, Shahram
    Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol, SE-17176 Stockholm, Sweden..
    Pharmacological agents preceding a diagnosis of immune thrombocytopenia in adult patients developing the chronic form: A Swedish national register study2017Inngår i: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 160, s. 27-31Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Patients with primary chronic immune thrombocytopenia (cITP) have been reported to use more anti-infective medications, even before diagnosis of immune thrombocytopenia (ITP). The more common use of anti-infective medications may be due to general health problems, requiring medication in the early stages of cITP and before the diagnosis is set, rather than infections preceding the disease. Accordingly, cITP may not only be associated with use of anti-infective medications but also with medications for more general symptoms.

    Objective: To investigate use of medications for general symptoms, such as analgesics and vitamin supplements in patients with ITP developing the chronic form, the year preceding their first primary diagnosis in comparison with such use in the general population.

    Method: Swedish Health Registers were used to identify adult patients (n = 1087) with primary cITP during 2006-2012 and data on medications. Standardized Incidence Ratios (SIRs) and 95% confidence intervals (CI), were estimated as a measure of relative risk.

    Results: The association for overall studied medications was SIR = 1.36 (95% CI 1.32-1.41). A majority of the point estimates were above unity.

    Conclusion: In patients with cITP, prescription fills for medications used to treat pain conditions and vitamin deficiencies are more common in the year preceding their first diagnosis as compared with prescription fills in the general population. Our results suggest that patients later diagnosed with cITP receive treatment due to symptoms that could be signs of an early ITP. Accordingly, in investigations for unspecific pain symptoms and vitamin deficiencies, cITP should be considered as a differential diagnosis.

  • Hoppe, Magnus
    Mälardalens högskola, Akademin för ekonomi, samhälle och teknik. Mälardalens högskola, Akademin för innovation, design och teknik, Innovation och produktrealisering.
    Through the membranes: Reflections on how we depict ideas for innovation2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    This article, just like innovation processes, revolves around ideas; ideas that has to be instigated, developed and put to use before they become organizational and societal innovations. Innovation ideas are in this respect quite complex and contextual. At the same time, the symbol commonly used for depicting ideas is quite simple and generic - a light bulb. Even though we are satisfied with the current situation, we might ask ourselves how would a communicative idea symbol fit for innovation look like? Symbols are adopted through a process of social consent. In that perspective, it appears pointless to challenge current use in order to replace the light bulb. The aim of the article is though not thus. Instead, it is to start a research dialogue on current use of preferred symbols for organizational innovation. The article describes how ideas are developed at the rim of formal organizations before penetrating the boundary getting in; and secondly how ideas need to penetrate the boundary of the organization getting out at launch. Hence, innovation can be viewed as a process of developing ideas in order to penetrate membranes. The article suggests a new symbol for ideas as “enlightened paths on a black orb”

  • Fritz, Johanna
    et al.
    Mälardalens högskola, Akademin för hälsa, vård och välfärd, Hälsa och välfärd.
    Elvén, Maria
    Mälardalens högskola, Akademin för hälsa, vård och välfärd, Hälsa och välfärd.
    Moberg, Johan
    Mälardalens högskola, Akademin för hälsa, vård och välfärd, Hälsa och välfärd.
    Från klinikbesök till klinikhandledning: Om verksamhetsförlagd utbildning i fysioterapeutprogrammet vid Mälardalens Högskola2015Rapport (Annet vitenskapelig)
  • Disputas: 2018-02-23 14:00 Kollegiesalen, Stockholm
    Tympakianaki, Athina
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Byggvetenskap, Transportplanering, ekonomi och teknik.
    Demand Estimation and Bottleneck Management Using Heterogeneous Traffic Data2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Congestion on urban and freeway networks has become a major problem, leading to increased travel times and reduced traffic safety. In order to suggest traffic management solutions to improve the transport system efficiency, it is important to capture the travel demand patterns, expressed as origin-destination (OD) matrices, and understand the mechanisms of traffic bottlenecks. The increasing availability of traffic data offers significant opportunities to effectively address these issues. The thesis uses heterogeneous traffic data to improve three important problems.

    The first problem relates to the dynamic OD estimation problem, which entails significant challenges due to its complexity. The Simultaneous Perturbation Stochastic Approximation (SPSA) algorithm has been commonly used to solve the problem, which can handle any available data that can improve the estimation accuracy. However, it encounters stability and convergence issues. The thesis proposes a general modification of SPSA, called cluster-wise SPSA (c-SPSA), that has more robust performance and finds better solutions. Its efficiency is demonstrated through simulation experiments for a network from Stockholm.

    The second problem focuses on the development of methods for utilizing heterogeneous traffic data for the analysis and management of freeway work zone and tunnel bottlenecks. Simulation is used as the means to evaluate and optimize various mitigation strategies for each case.

    The third problem analyzes multimodal impacts due to network disruptions for the case of tunnel bottlenecks, using a data-driven approach. Tunnel congestion is often dealt with temporary closures, which may cause significant disruptions. It is crucial to identify the potential multimodal impacts of such interventions so as to design efficient and proactive mitigation strategies. The thesis shows the benefits of combining multiple data sources to analyze the impacts of temporary tunnel closures for a freeway tunnel in Stockholm.

  • Alskär, Oskar
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Karlsson, Mats O.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Kjellsson, Maria C.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Model-Based Interspecies Scaling of Glucose Homeostasis2017Inngår i: CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, ISSN 2163-8306, Vol. 6, nr 11, s. 778-786Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Being able to scale preclinical pharmacodynamic response to clinical would be beneficial in drug development. In this work, the integrated glucose insulin (IGI) model, developed on clinical intravenous glucose tolerance test (IVGTT) data, describing dynamic glucose and insulin concentrations during glucose tolerance tests, was scaled to describe data from similar tests performed in healthy rats, mice, dogs, pigs, and humans. Several approaches to scaling the dynamic glucose and insulin were investigated. The theoretical allometric exponents of 0.75 and 1, for clearances and volumes, respectively, could describe the data well with some species-specific adaptations: dogs and pigs showed slower first phase insulin secretion than expected from the scaling, pigs also showed more rapid insulin dependent glucose elimination, and rodents showed differences in glucose effectiveness. The resulting scaled IGI model was shown to accurately predict external preclinical IVGTT data and may be useful in facilitating translations of preclinical research into the clinic.

  • Disputas: 2018-02-23 09:30 J1650, Karlskrona
    Georgsson, Mattias
    Blekinge Tekniska Högskola, Fakulteten för datavetenskaper, Institutionen för kreativa teknologier.
    Toward Patient-centered, Standardized, and Reproducible Approaches of Evaluating the Usability of mHealth Chronic Disease Self-management Systems for Diabetes2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Diabetes is a chronic disease affecting 422 million patients worldwide according to World Health Organization data with 30.3 million in the United States and 64 million in Europe. The prevalence speaks to the need for improved ways to support patients in disease self-management. mHealth solutions are increasingly used for this; however, usability is a current challenge affecting patients’ mHealth use. Recent literature emphasizes an increased focus on patient-centeredness in diabetes care, user-centeredness in chronic disease mHealth system design and standardized, systematic approaches for usability evaluation. The aim of this thesis and its individual studies was to incorporate these foci into the evaluation of two mobile health self-management systems for diabetes.

    Study I used ISO standard 9241-11 to examine the relationship between selected group characteristics of diabetes patients on specific interaction outcomes to quantitatively identify needed system modifications. Study II utilized a multi-method design to assess diabetes patients’ mHealth usage and combined two novel analytic methods to structure and analyze results. Study III used a modified, user-oriented heuristic evaluation (HE) method, validated tasks and in-depth severity factor ratings to identify critical problems from patients’ point of view. By developing and employing a modified, user-centered cognitive walkthrough method (UC-CW), study IV assessed its effectiveness and efficiency in finding relevant usability problems for users as well as patients’ acceptance. The modified CW was validated against the golden-standard user test with Think Aloud.

    Study I emphasized the importance of considering user characteristics in mHealth performance as these influenced interaction outcomes. All patients had difficulties with multiple-step tasks. Patients more recently diagnosed were able to perform tasks more successfully, with fewer errors and at faster times and had higher satisfaction scores; similar outcomes to the more experienced users. Educational level did not, however, seem to influence performance. In study II, the usability test with Think-Aloud (TA), in-depth interviews and questionnaires contributed to 19 consolidated issues, and triangulated on 5 critical usability problems for users. The combined analysis methods resulted in structured, categorized descriptions to aid in problem-solving. In Study III, the disease-related, critical information deficiencies found by expert evaluators using the modified, structured method also converged on and highlighted potentially adverse user concerns. Study IV demonstrated that the UC-CW found more critical user problems compared to the user test with TA despite both methods producing similar major average severity ratings and violations of heuristic categories. The modified method was more efficient per detected problem and experienced as less cognitively demanding and with a higher ease of use.

    These studies offer different approaches that include patient-centered, efficient and user-acceptable methods and method modifications to detect critical usability issues for users. Importantly, improved mHealth designs for users could mean improvement in interactions, interaction performance, increased adoption, and long-term perhaps even increased adherence to interventions for chronic conditions.

  • Lauer, Axel
    et al.
    Jones, Colin
    Eyring, Veronika
    Evaldsson, Martin
    SMHI, Forskningsavdelningen, Klimatforskning - Rossby Centre.
    Stefan, Hagemann A.
    Makela, Jarmo
    Martin, Gill
    Roehrig, Romain
    Wang, Shiyu
    SMHI, Forskningsavdelningen, Klimatforskning - Rossby Centre.
    Process-level improvements in CMIP5 models and their impact on tropical variability, the Southern Ocean, and monsoons2018Inngår i: Earth System Dynamics, ISSN 2190-4979, E-ISSN 2190-4987, Vol. 9, nr 1, s. 33-67Artikkel i tidsskrift (Fagfellevurdert)
  • Krenek, Alexander
    et al.
    Austrian Institute of Economic Research (WIFO).
    Sommer, Mark
    Austrian Institute of Economic Research (WIFO).
    Schratzenstaller, Margit
    Austrian Institute of Economic Research (WIFO).
    Sustainability-oriented Future EU Funding: A European border carbon adjustment2018Rapport (Fagfellevurdert)
    Abstract [en]

    The need to reform EU funding and recent political developments such as Brexit and the withdrawal from the United States from the 2015 Paris climate agreement could revitalize the debate about the introduction of border carbon adjustments (BCA) for the European emission trading system (ETS). The introduction of a BCA would allow the EU to phase out current carbon leakage provisions of the ETS and to auction off all emission allowances, thus rendering the ETS a more effective unilateral tool to price and reduce carbon emissions. By using a dynamic new Keynesian (DYNK) model, we estimate that a BCA for the ETS would generate substantial and stable revenues. Given different assumptions about the development of the carbon intensity of non-EU production and different BCA designs we find that estimated revenues would suffice to finance between a third and all of current EU expenditures by the year 2027, thus allowing Member States to reduce their current contributions to the EU budget accordingly. Administered at the EU borders a BCA would represent a sustainability-oriented instrument to finance the EU allowing EU Member States to cut more distortionary taxes such as those on labour, thereby increasing growth- and employment-friendliness of taxation. The proposed measure could thus contribute to tackle both environmental and fiscal challenges currently facing the EU.

  • Karlsudd, Peter
    Linnéuniversitetet, Fakulteten för samhällsvetenskap (FSV), Institutionen för pedagogik och lärande (PEL).
    Att problematisera ”problemet”: Bedömning och utveckling av problemformuleringar i lärarutbildningens självständiga arbeten: [To problematize the ’problem’: Assessment and development of problem formulations in independent theses projects in teacher education]2018Inngår i: Nordic Journal of Vocational Education and Training, ISSN 2242-458X, E-ISSN 2242-458X, Vol. 8, nr 1, s. 1-22Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    How well a research problem is formulated in theses, according to many educators and textbook writers, is of great importance for the final quality of a thesis project. To investigate if there is a link between the construction and formulations of a problem and the grades well accepted and accepted, 58 theses projects were reviewed. 82 students were tested on their ability to evaluate, discuss and formulate research problems through specific exercises. The results of the comparison between how the research problem was designed and the theses gradings show that a well-formulated problem is not an absolute necessity for the grade well accepted. However, the results indicate that writers who strive to express higher ambitions when it comes to the problem have a greater opportunity to realize these in their thesis. Highly formulated problems have been well represented among the theses that receive the grade well accepted.

    The conclusion of the study shows that a well constructed purpose and problem is of particular importance to achieve a good standard of a thesis project and the specific training efforts undertaken suggest that this training will continue as a regular feature of the programme.

  • Galli, Raoul
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Socialantropologiska institutionen.
    Björklund, Ulf
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Socialantropologiska institutionen.
    Nyckelbegrepp i socialantropologin: Ulf Björklund, Ulf Hannerz & Socialantropologiska institutionen, Stockholms universitet 2018/19832018Collection/Antologi (Annet vitenskapelig)
  • Taymaz, Tuncay
    et al.
    Nilfouroushan, Faramarz
    Högskolan i Gävle, Akademin för teknik och miljö, Avdelningen för Industriell utveckling, IT och Samhällsbyggnad, Samhällsbyggnad, GIS.
    Yolsal-Çevikbilen, Seda
    Eken, Tuna
    Co-seismic Crustal Deformation of the 12 November 2017 Mw 7.4Sar-Pol-Zahab (Iran) Earthquake: integration of analysis based on DInSAR and seismological observations2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    The November 12, 2017 Mw 7.4 earthquake that trembled near the border region between Halabjah (Iraq) andSarpol-e Zahab (Iran) is the largest ever-recorded earthquake in the Zagros Mountains since 1900. The epicenterlocation of the event suggests that the NNW trending Mountain Front Fault (MFF) has been responsible for theearthquake though it was not associated with surface faulting. Analysis of teleseismic P- and SH- body-waveformsdata indicate a well-constrained rupture propagated along the dip direction of the fault plane with an effectiverupture area of 80km long, 70km wide and focal depth of 192 km ENE dipping low-angle thrust faulting with asmall strike-slip component that produced little uplift in the region (Strike: 358o; Dip: 16o, Rake: 149o and SeismicMoment (Mo): 1.828x1020 N.m. with maximum displacement (Dmax) of 6.9m at hypocenter, and rupture velocity(Vr) of 3.2 km/s). The source rupture duration is about 45s, but the main moment release is observed in the first10s. Focal mechanism solution of the event indicates a NNW trending plane dipping 16 degrees ENE. This isin agreement with the dip direction of the MFF and the distribution of aftershocks covering an area some 50-70km wide. We explore its details in astonishment, if it is proved, that the Zagros Mountain Front fault (MFF) wasresponsible then it might have become curved at depth (?)To measure the co-seismic crustal deformation around the epicenter, we processed the ascending and descendingSentinel-1 SAR images, collected before and after the earthquake, by SNAP software and generated the interferogramsof surface deformation. The Differential InSAR (DInSAR) results show an upward and downward displacementsof 90 cm and 30 cm around the epicenter respectively. Furthermore, we investigate the differencebetween strike derived from seismological and that inferred from DInSAR satellite observations, and its possiblecauses.We do not have “best” or “right” rupture model yet, but just models satisfying for specific data sets. The aftermathof earthquakes like the 2017 Halabjah (Irak)-Sarpol-e Zahab (˙Iran) provides excellent opportunity to evaluate ourunderstanding of earthquakes and their hazards in the earthquake prone regions.

  • Kadhim, Ali
    et al.
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Signaler och system.
    Moaveni, Bijan
    School of Railway Engineering, Iran University of Science and Technology, Teh.
    Birk, Wolfgang
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Signaler och system.
    Castaño Arranz, Miguel
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Signaler och system.
    Validity of Decentralized Control Configurations with Respect to Model Uncertainty2018Inngår i: Journal of Process Control, ISSN 0959-1524, E-ISSN 1873-2771Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This paper proposes a method to indicate the minimum uncertainty on nominal system gains for which a decentralized control configuration is invalid. The outset for the method is that a decentralized control configuration is selected based on the nominal system model using the relative interaction array (RIA) methodology. Thereafter for the uncertain system, the minimum relative uncertainty parameter which invalidates the current control configuration decision is determined. Hence, a powerful tool is provided to indicate to what extent a certain configuration of a decentralized controller is still recommended in the presence of the uncertainty. Examples to illustrate the proposed method for a 2x2 distillation column and a 5x5 stock-preparation process are given.

  • Söderberg, Andreas
    et al.
    RISE - Research Institutes of Sweden, Säkerhet och transport, Elektronik.
    Hedberg, Johan
    RISE - Research Institutes of Sweden, Säkerhet och transport, Elektronik.
    Folkesson, Peter
    RISE - Research Institutes of Sweden, Säkerhet och transport, Elektronik.
    Jacobson, Jan
    RISE - Research Institutes of Sweden, Säkerhet och transport, Elektronik.
    Safety-related Machine Control Systems using standard EN ISO 13849-12018Rapport (Annet vitenskapelig)
    Abstract [en]

    Machine control systems shall be designed according to the European Machinery Directive and appropriate European standards. This report gives guidance when applying EN ISO 13849-1:2015 in projects, both for companies developing subsystems and for companies that are developing complete machines.

  • Pikwer, Andreas
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Mälarsjukhuset.
    Castegren, Markus
    Karolinska Univ Hosp, Perioperat Med & Intens Care PMI, Stockholm, Sweden.;Karolinska Inst, Clintec, Stockholm, Sweden..
    Namdar, Sijal
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Mälarsjukhuset.
    Blennow, Kaj
    Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden..
    Zetterberg, Henrik
    Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden.;UCL, Inst Neurol, Dept Mol Neurosci, Queen Sq, London, England..
    Mattsson, Niklas
    Lund Univ, Clin Memory Res Unit, Fac Med, Lund, Sweden.;Skane Univ Hosp, Dept Neurol, Lund, Sweden..
    Effects of surgery and propofol-remifentanil total intravenous anesthesia on cerebrospinal fluid biomarkers of inflammation, Alzheimer's disease, and neuronal injury in humans: a cohort study2017Inngår i: Journal of Neuroinflammation, ISSN 1742-2094, E-ISSN 1742-2094, Vol. 14, artikkel-id 193Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Surgery and anesthesia have been linked to postoperative cognitive disturbance and increased risk of Alzheimer's disease. It is not clear by which mechanisms this increased risk for cognitive disease is mediated. Further, amyloid beta production has been suggested to depend on the sleep-wake cycle and neuronal activity. The aim of the present study was to examine if cerebrospinal fluid (CSF) concentrations of a number of biomarkers for Alzheimer's disease-related processes, including amyloid beta, neuronal injury, and inflammation, changed over time during intravenous anesthesia in surgical patients. Methods: We included patients scheduled for hysterectomy via laparotomy during general anesthesia with intravenous propofol and remifentanil. CSF samples were obtained before, during, and after surgery (5 h after induction) and tested for 27 biomarkers. Changes over time were tested with linear mixed effects models. Results: A total of 22 patients, all females, were included. The mean age was 50 years (+/- 9 SD). The mean duration of the anesthesia was 145 min (+/- 40 SD). Interleukin (IL)-6, IL-8, monocyte chemoattractant protein 1, and vascular endothelial growth factor A increased over time. IL-15 and IL-7 decreased slightly over time. Macrophage inflammatory protein 1 beta and placental growth factor also changed significantly. There were no significant effects on amyloid beta (A beta) or tau biomarkers. Conclusions: Surgery and general anesthesia with intravenous propofol and remifentanil induce, during and in the short term after the procedure, a neuroinflammatory response which is dominated by monocyte attractants, without biomarker signs of the effects on Alzheimer's disease pathology or neuronal injury.

  • De Blanche, Andreas
    et al.
    Högskolan Väst, Institutionen för ingenjörsvetenskap, Avdelningen för Matematik, Data- och Lantmäteriteknik.
    Lundqvist, Thomas
    Högskolan Väst, Institutionen för ingenjörsvetenskap, Avdelningen för Matematik, Data- och Lantmäteriteknik.
    Node Sharing for Increased Throughput and Shorter Runtimes: an Industrial Co-Scheduling Case Study2018Inngår i: Proceedings of the 3rd Workshop on Co-Scheduling of HPC Applications (COSH 2018): Held together with HiPEAC 2018 / [ed] Trinitis, Carsten; Weidendorfer, Josef, 2018, s. 15-20Konferansepaper (Fagfellevurdert)
    Abstract [en]

    The allocation of jobs to nodes and cores in industrial clusters is often based on queue-system standard settings, guesses or perceived fairness between different users and projects. Unfortunately, hard empirical data is often lacking and jobs are scheduled and co-scheduled for no apparent reason. In this case-study, we evaluate the performance impact of co-scheduling jobs using three types of applications and an existing 450+ node cluster at a company doing large-scale parallel industrial simulations. We measure the speedup when co-scheduling two applications together, sharing two nodes, compared to running the applications on separate nodes. Our results and analyses show that by enabling co-scheduling we improve performance in the order of 20% both in throughput and in execution times, and improve the execution times even more if the cluster is running with low utilization. We also find that a simple reconfiguration of the number of threads used in one of the applications can lead to a performance increase of 35-48% showing that there is a potentially large performance increase to gain by changing current practice in industry.

  • Cappel, Ute B.
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Svanström, Sebastian
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Lanzilotto, Valeria
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Johansson, Fredrik O. L.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Aitola, Kerttu
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi.
    Philippe, Bertrand
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Giangrisostomi, Erika
    Helmholtz Zentrum Berlin GmbH, Inst Methods & Instrumentat Synchrotron Radiat Re, Albert Einstein Str 15, D-12489 Berlin, Germany..
    Ovsyannikov, Ruslan
    Helmholtz Zentrum Berlin GmbH, Inst Methods & Instrumentat Synchrotron Radiat Re, Albert Einstein Str 15, D-12489 Berlin, Germany..
    Leitner, Torsten
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Foehlisch, Alexander
    Helmholtz Zentrum Berlin GmbH, Inst Methods & Instrumentat Synchrotron Radiat Re, Albert Einstein Str 15, D-12489 Berlin, Germany.;Univ Potsdam, Inst Phys & Astron, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany..
    Svensson, Svante
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Mårtensson, Nils
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik. Uppsala Berlin Joint Lab Next Generat Photoelectr, Albert Einstein Str 15, D-12489 Berlin, Germany..
    Boschloo, Gerrit
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi.
    Lindblad, Andreas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Rensmo, Håkan
    Partially Reversible Photoinduced Chemical Changes in a Mixed-Ion Perovskite Material for Solar Cells2017Inngår i: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 9, nr 40, s. 34970-34978Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Metal halide perovskites have emerged as materials of high interest for solar energy-to-electricity conversion, and in particular, the use of mixed-ion structures has led to high power conversion efficiencies and improved stability. For this reason, it is important to develop means to obtain atomic level understanding of the photoinduced behavior of these materials including processes such as photoinduced phase separation and ion migration. In this paper, we implement a new methodology combining visible laser illumination of a mixed-ion perovskite ((FAP-bI(3))(0.85)(MAPbBr(3))(0.15)) with the element specificity and chemical sensitivity of core-level photoelectron spectroscopy. By carrying out measurements at a synchrotron beamline optimized for low X-ray fluxes, we are able to avoid sample changes due to X-ray illumination and are therefore able to monitor what sample changes are induced by visible illumination only. We find that laser illumination causes partially reversible chemistry in the surface region, including enrichment of bromide at the surface, which could be related to a phase separation into bromide- and iodide-rich phases. We also observe a partially reversible formation of metallic lead in the perovskite structure. These processes occur on the time scale of minutes during illumination. The presented methodology has a large potential for understanding light-induced chemistry in photoactive materials and could specifically be extended to systematically study the impact of morphology and composition on the photostability of metal halide perovskites.

  • Ahnborg, Johan
    et al.
    Kungl. Konsthögskolan.
    Andersson, Ingela
    Kungl. Konsthögskolan.
    Ekberg, Micael
    Kungl. Konsthögskolan.
    Fyrand, Kristin
    Kungl. Konsthögskolan.
    Geijer, Mia
    Kungl. Konsthögskolan.
    Ljugné, Peter
    Kungl. Konsthögskolan.
    Lundgren, Ulrika
    Kungl. Konsthögskolan.
    Reinholdsson, Ann-Mari
    Kungl. Konsthögskolan.
    Stone, Andrew
    Kungl. Konsthögskolan.
    Ågren, Maria
    Kungl. Konsthögskolan.
    Bedoire, Fredric ()
    Kungl. Konsthögskolan.
    Bach, Lone-Pia ()
    Kungl. Konsthögskolan.
    Lindgren, Nina ()
    Kungl. Konsthögskolan.
    Örebro slott: Slott och borgar2000Rapport (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    En majoritet av dagens byggnadsuppgifter gäller att hantera det redan byggda. När vi står inför situationen att restaurera en befintlig byggnad är det viktigt att förstå olika tidsperioders stilideal liksom byggnadsteknik och material. Först då kan vi göra en väl avvägd analys som tar tillvara och utvecklar de kvaliteter som byggnaderna själva besitter. Därför är utbildningen upplagd som ett växelspel mellan föreläsningar, seminarier, exkursioner och en för året vald studieavgift.Slott och brogar har varit läsårets tema. Vi har valt att arbeta med Västerås och Örebro slott - två ganska bortglömda Vasaslott som är väl värda att lyfta fram, Särskilt har vi studerat de senaste 300 årens förändringar, som inte tidigare ägnats lika stor forskarmöda som medeltiden och Vasatiden. I dessa två exempel finns en provkarta på estetiska, praktiska och tekniska ingrepp på Carl Hårlemans tid och fram till idag.Studierna har således omfattat både gestaltning, funktion och byggnadsteknik. Avsikten är att visa på kvaliteterna i de omvandlingar och restaureringar som skett, men också att peka på problem och analysera olika möjligheter inför framtiden. Arbetet har skett i samarbete med Statens fastighetsverk och är tänkt att utgöra ett underlag till vårdprogram och framtida restaureringsinsatser,  

  • Taxén, Lars
    Linköpings universitet, Institutionen för datavetenskap. Linköpings universitet, Tekniska fakulteten.
    Reconfiguring Sociomateriality from a Neurobiological Perspective2018Inngår i: Australasian Journal of Information Systems, ISSN 1449-8618, Vol. 22Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of this paper is to propose a reconfiguration of sociomateriality (SM) from a neurobiological perspective, which maintains the relational ontology of SM without relapsing into untenable entanglement positions of strong SM (SSM).

  • Bas-Hoogendam, Janna Marie
    et al.
    Leiden Univ, Inst Psychol, Wassenaarseweg 52, NL-2333 AK Leiden, Netherlands.;Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.;Leiden Inst Brain & Cognit, Leiden, Netherlands..
    van Steenbergen, Henk
    Leiden Univ, Inst Psychol, Wassenaarseweg 52, NL-2333 AK Leiden, Netherlands.;Leiden Inst Brain & Cognit, Leiden, Netherlands..
    Pannekoek, J. Nienke
    Imperial Coll London, Div Brain Sci, Ctr Psychiat, Neuropsychopharmacol Unit, London, England..
    Fouche, Jean-Paul
    Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa..
    Lochner, Christine
    UCT MRC Unit Anxiety & Stress Disorders, Cape Town, South Africa.;Univ Stellenbosch, Dept Psychiat, Tygerberg, South Africa..
    Hattingh, Coenraad J.
    Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa..
    Cremers, Henk R.
    Univ Amsterdam, Dept Clin Psychol, Amsterdam, Netherlands..
    Furmark, Tomas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Månsson, Kristoffer N.T.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Stockholm Univ, Dept Psychol, Stockholm, Sweden.;Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden..
    Frick, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden..
    Engman, Jonas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Boraxbekk, Carl-Johan
    Umea Univ, Umea Ctr Funct Brain Imaging UFBI, Umea, Sweden.;Copenhagen Univ Hosp Hvidovre, Ctr Funct & Diagnost Imaging & Res, DRCMR, Hvidovre, Denmark..
    Carlbring, Per
    Stockholm Univ, Dept Psychol, Stockholm, Sweden..
    Andersson, Gerhard
    Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Linkoping Univ, Dept Behav Sci & Learning Psychol, Linkoping, Sweden..
    Fredrikson, Mats
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden..
    Straube, Thomas
    Univ Munster, Inst Med Psychol & Syst Neurosci, Munster, Germany..
    Peterburs, Jutta
    Univ Munster, Inst Med Psychol & Syst Neurosci, Munster, Germany..
    Klumpp, Heide
    Univ Illinois, Dept Psychiat, Chicago, IL USA.;Univ Illinois, Dept Psychol, Chicago, IL USA..
    Phanp, K. Luan
    Univ Illinois, Dept Psychiat, Chicago, IL USA.;Univ Illinois, Dept Psychol, Chicago, IL USA..
    Roelofs, Karin
    Radboud Univ Nijmegen, Behav Sci Inst, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands..
    Veltman, Dick J.
    Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Neurosci Campus Amsterdam, Amsterdam, Netherlands..
    van Tol, Marie-Jose
    Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, Groningen, Netherlands..
    Stein, Dan J.
    Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa.;UCT MRC Unit Anxiety & Stress Disorders, Cape Town, South Africa..
    van der Wee, Nic J. A.
    Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.;Leiden Inst Brain & Cognit, Leiden, Netherlands..
    Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder2017Inngår i: NeuroImage: Clinical, ISSN 0353-8842, E-ISSN 2213-1582, Vol. 16, s. 678-688Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Social anxiety disorder (SAD) is a prevalent and disabling mental disorder, associated with significant psychiatric comorbidity. Previous research on structural brain alterations associated with SAD has yielded inconsistent results concerning the direction of the changes in graymatter (GM) in various brain regions, as well as on the relationship between brain structure and SAD-symptomatology. These heterogeneous findings are possibly due to limited sample sizes. Multisite imaging offers new opportunities to investigate SAD-related alterations in brain structure in larger samples. An international multi-center mega-analysis on the largest database of SAD structural T1-weighted 3T MRI scans to date was performed to compare GM volume of SAD-patients (n = 174) and healthy control (HC)-participants (n = 213) using voxel-based morphometry. A hypothesis-driven region of interest (ROI) approach was used, focusing on the basal ganglia, the amygdala-hippocampal complex, the prefrontal cortex, and the parietal cortex. SAD-patients had larger GM volume in the dorsal striatum when compared to HC-participants. This increase correlated positively with the severity of self-reported social anxiety symptoms. No SAD-related differences in GM volume were present in the other ROIs. Thereby, the results of this mega-analysis suggest a role for the dorsal striatum in SAD, but previously reported SAD-related changes in GM in the amygdala, hippocampus, precuneus, prefrontal cortex and parietal regions were not replicated. Our findings emphasize the importance of large sample imaging studies and the need for meta-analyses like those performed by the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium.

  • Bengtsson, Ylva
    et al.
    Kungl. Konsthögskolan.
    Fredriksson, Mats
    Kungl. Konsthögskolan.
    Gustén, Ingela
    Kungl. Konsthögskolan.
    Herdevall, Gabriel
    Kungl. Konsthögskolan.
    Isola, Oiva
    Kungl. Konsthögskolan.
    Jonsson Gremo, Ingrid
    Kungl. Konsthögskolan.
    Lindström, Malin
    Kungl. Konsthögskolan.
    Palmer, Henrietta
    Kungl. Konsthögskolan.
    Deurell, Jens
    Kungl. Konsthögskolan.
    Gustavsson, Karin
    Kungl. Konsthögskolan.
    Haugen, Synnöve
    Kungl. Konsthögskolan.
    Hoffman-Rex, Kristina
    Kungl. Konsthögskolan.
    Johansson, Kalle
    Kungl. Konsthögskolan.
    Kull, Carita
    Kungl. Konsthögskolan.
    Olerud Staberg, Petra
    Kungl. Konsthögskolan.
    Wärn, Carl
    Antell, Olof ()
    Kungl. Konsthögskolan.
    von Knorring, Peter ()
    Kungl. Konsthögskolan.
    Bedoire, Fredric ()
    Kungl. Konsthögskolan.
    Ulriksdals slott under 350 år1995Rapport (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Studierna har utgått från Ulriksdals slott, uppfört av Jacob De la Gardie för 350 år sedan. Som kungligt slott har Ulriksdal genomgått ombyggnader under 1600 - och 1700-talet, men präglas idag mest av Karl XVs omfattande omdaning på 1850-talet och Gustav VI Adolfs lika genomgripande förändringar på 1920-talet.Slottet har bjudit på rika studiemöjligheter av stilideal, planlösning, interiörgestaltning, snickerikultur och stormtekniska system från hela 350-årsperioden. Genom noggranna uppmätningar och inventeringar på plats kopplade till arkivstudier har slottets komplicerade förändringshistoria kunnat analyseras, 

  • Blake, Vic
    et al.
    Nottingham, UK.
    Hearn, Jeff
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap. Hanken School of Economics, Helsinki, Finland; University of Huddersfield, Huddersfield, UK.
    Jackson, David
    Nottingham, UK.
    Barber, Randy
    Nottingham, UK.
    Johnson, Richard
    Leicester, UK.
    Luczynski, Zbyszek
    Nottingham, UK.
    Ageing, gender politics and masculinities : Reflections on collective memory work with older men2017Inngår i: Working with older people, ISSN 1366-3666Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose: The purpose of this paper is to reflect on the process of participating in a long-term collective memory work group of older men, focusing on the making/unmaking of older men and masculinities, and the potential of memory work with older men.

    Design/methodology/approach: Participant review and reflection on collective memory work with a group of older men.

    Findings: Collective memory work provides a novel way to explore ageing, gendering, men, and masculinities. Its potential for working with older men is examined critically in relation to gender politics, power and (in)equalities, interconnections and contradictions of men’s ageing and gendering, the personal and the political, as well as working with older men more generally, including those in transition and crisis.

    Originality/value: There is little previous writing on this approach to ageing, men, and masculinities. The paper aims to stimulate wider applications of this approach.

  • Boberg, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio philologica, de voto Naziræorum in gente Hebræa, ex Num. VI. quam, consent. ampl. facult. philosoph. in regia academia Upsaliensi, sub præsidio ... Andreæ Boberg ... pro gradu publico eruditorum examini modeste subjicit, stipendiarius Nesselianus, Johannes Milenius, Westmannus. In audit. Carol. maj. d. XI. Junii, anni MDCCLV. h. a. m. s.1755No name for locale no (Annet vitenskapelig)
  • Disputas: 2018-02-23 13:30 F3, Stockholm
    Selamtzis, Andreas
    KTH, Skolan för elektroteknik och datavetenskap (EECS).
    Analyses of voice and glottographic signals in singing and speech2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Recent advances in machine learning and time series analysis techniques have brought new perspectives to a great number of scientific fields. This thesis contributes applications of such techniques to voice analysis, in an attempt to extract information on the vibration of the vocal folds as such, as well as on the radiated acoustic signal. The data that was analyzed in this work are acoustic recordings, electroglottographic (EGG) signals and transnasal high- speed videoendoscopic images. The data analysis techniques are primarily based on clustering, i.e., grouping of data based on similarity, and sample entropy analysis, i.e., quantifying the degree of irregularity in a given signal. The experiments were conducted so as to provide data for different types of vibratory behaviors (or vibratory states) of the vocal folds. Clustering was used in order to categorize in an unsupervised fashion these different vi- bratory states, based solely on the electroglottographic signal, or the glottal area waveform, or both. Sample entropy was utilized as an indicator of in- stabilities, when subjects produced voiced sounds using irregular vibratory patterns, such as register breaks, intermittent diplophonia, and other types of irregularities. The prominent role of sound pressure level and fundamental frequency motivated further study of the relationship between them and the shape of the electroglottographic waveform. Graphical representations were created to visualize the relationship between different vibratory behaviors with fundamental frequency and sound pressure level. The EGG waveform shape was seen to depend strongly on sound pressure level and somewhat less on fundamental frequency. In very soft phonation, the almost sinusoidal waveform of the EGG suggests that studying the EGG using clusters may give a better representation compared to conventional time-domain metrics. The paradigm of the clustering was later applied in synchronous recordings of electroglottogram and glottal area waveforms in professional tenor singers. Different vibratory states were classified successfully using clustering, and the electroglottogram was seen to be as good as the glottal area waveform for such a classification task. The last part of this work concerns voices from subjects with organic dysphonia. A study was dedicated to investigate how vowel context (sustained versus excerpted from speech) can affect the power of quantitative acoustic measures to discriminate dysphonic subjects from controls. Two acoustic voice quality measures were used: the cepstral peak prominence (smoothed) and sample entropy. The cepstral peak prominence (smoothed) showed better discriminatory power with excerpted vowels, while sample entropy with sustained vowels. Additionally, it was found that sample entropy was strongly correlated with cepstral peak prominence (smoothed) and with the perceptual quality of breathiness. 

  • Boberg, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio philologico-historica, de fatis literaturæ Hebrææ seculo reformationis, cujus partem I. venia ampliss. ordin. philosoph. in regia acad. Upsal. sub præsidio ... Andreæ Boberg ... pro gradu publico examini submittit stipendiarius Nesselianus, Ericus L. Hydrén, Sudermannus. In audit. Carol. maj. d. V. Maji, anni M DCC LV. h. a. m. s., P. 11755No name for locale no (Annet vitenskapelig)
  • Boberg, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio philologica, de sortibus Hebræorum, quam consensu ampliss. facult. philos. in reg. acad. Upsal. sub moderamine ... Andreæ Boberg ... publico examini modeste subjicit Ericus Klint, Uplandus, in audit. Carol. majori die I. Julii, anno MDCCLIV. h. a. m. s.1754No name for locale no (Annet vitenskapelig)
  • Hall, Matthew
    et al.
    University od Derby, Derby, UK.
    Hearn, Jeff
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap. University of Huddersfield, Huddersfield, UK; School of Economics, Helsinki, Finland .
    Pornography: non-consensual, vengeful, online2017Inngår i: NOTA News, Vol. 82, s. 16-18Artikkel i tidsskrift (Annet vitenskapelig)
  • Boberg, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio philologica, de successore Davidis, ex II Samuel. VII. 12. seqq. quam suffragante ampliss. senat. phil. in illustri academia Upsaliensi, sub præsidio ... Andreæ Boberg ... pro gradu ad publicum examen modeste defert Ericus Stigzelius, Angermannus, in auditorio Carol. maj. d. IX. Junii anni MDCCLII. Horis, post meridiem, consvetis.1752No name for locale no (Annet vitenskapelig)
  • Boberg, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Ketav 'Ivri mi-keli hiluf seu de charactere Hebræo s. codicis non mutato ab Esdra, dissertatio philologica, quam, consensu ampliss. facult. philos. in illustri academia Upsaliensi, præside ... Andrea Boberg ... pro gradu, publice ventilandam sistit stipendiarius Stieglerianus Petrus Tegnæus, Vester-Gothus. In audit. Carol. maj. ad d. [28] Maji anni MDCCLII. h. a. m. s.1752No name for locale no (Annet vitenskapelig)
  • Boberg, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio philologica, [semikat jadajjim al haz - zebahim] seu impositionem manuum in sacrificiis factam leviter adumbrans, quam consent. & adprob. ampliss. ord. philos. in regia acad. Upsal. præside ... Andrea Boberg ... pro gradu publice examinandam sistit Sigfrid Laur. Odelin, Smolandus, in auditorio Car. maj. ad d. [25] Maji an. MDCCLII. h. a. m. s.1752No name for locale no (Annet vitenskapelig)
  • Boberg, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Sheʾelath ʻÆlishaʻ sive de petitione Elisaei, ex II. Reg. II. dissertatio philologica, cujus partem alteram, suffragante ampliss. ord. philos. in regia academia Upsaliensi, sub praesidio ... Andr. Boberg ... pro consvetis in philosophia honoribus, ad publicum examen modeste defert Johannes Kihlström, Dalekarlus. In auditorio Carolino majori, die XII. Junii, anni MDCCLII. h. a. m. s.1752No name for locale no (Annet vitenskapelig)
  • Boberg, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Sheʾelath ʻÆlishaʻ sive de petitione Elisaei, ex II. Reg. II. dissertatio philologica. Cujus partem priorem, consent. ampliss. facult. philosoph. in regia academia Upsaliensi, sub praesidio ... Andr. Boberg ... publicae censurae modeste subjicit Johannes Kihlström, Faluna Dalekarlus, in auditorio Carolino majori, die VIII Decemb. anni MDCCL. h. a. m. s.1750No name for locale no (Annet vitenskapelig)
  • Boberg, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Meditationes philologicæ, de regina caeli, Jer. VII. & XLIV. quarum partem posteriorem, consensu ampliss. facult. philosoph. in regia academia Upsaliensi, sub præsidio ... Andreæ Boberg ... pro gradu publice examinandam sistit Joh. Hartman Eberhardt, Vestrobotniensis. In aud. Carol. majori, die [X] Junii anni MDCCLV. h. a. m. s.1755No name for locale no (Annet vitenskapelig)
  • Boberg, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Meditationes philologicæ, de malkath hashamayim Jer. VII. & XLIV. quarum partem priorem, consensu ampliss. facultatis philosophicæ in regia academia Upsaliensi, sub præsidio ... Andreæ Boberg ... publico eruditorum examini defert stipendiarius regius Joh. Hartm. Eberhardt, Vestrobotniensis. In auditor. Carol. maj. die 14 Novemb. ann MDCCL. h. a. m. s., P. 11750No name for locale no (Annet vitenskapelig)
  • Boberg, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Dissertatio philologica, mishchath malke Yisraʾel sive unctionem regum gentis Israëliticæ leviter delineans, quam, consensu ampliss. facultatis philosophicæ in regia academia Upsaliensi, præside ... Andrea Boberg ... pro gradu, ad publicum bonorum examen modeste defert stipendiarius regius, Ericus Forsner, Angermannus. In auditorio Carolino majori die VIII Junii, anni MDCCXLIX. Horis, ante meridiem, consvetis.1749No name for locale no (Annet vitenskapelig)
  • Boberg, Andreas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Filosofiska fakulteten.
    Specimen graduale de goʾel quod, consensu ampliss. facult. philos. Upsal. sub moderamine ... Andreæ Boberg ... modesto examini submittit Petrus Arosenius, Arosia Westmannus. In audit. Carol. majori die [13] Maji anno 1749. Horis ante meridiem consvetis.1749No name for locale no (Annet vitenskapelig)