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  • Linnarsson, Magnus
    et al.
    Stockholms universitet, Humanistiska fakulteten, Historiska institutionen.
    Hallenberg, Mats
    Stockholms universitet, Humanistiska fakulteten, Historiska institutionen.
    Towns go public: Urban services and the broadening ofurban communities in Scandinavia 1850–19202018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    From the mid-nineteenth century and onwards, debates on urban public services became an integral part of municipal politics in Nordic towns.  The industrial revolution came late in Nordic countries and the problem of how to integrate immigrants and factory workers into existing networks became paramount at the end of the century. This paper will discuss how municipal bodies tackled the problem of making the city accessible to new groups in the urban landscape.  

    New forms of infrastructure had been introduced by private initiative: water, gas, electricity, tramways etc. In city councils and popular press, proponents of equal access argued that such services should be controlled and provided by municipal bodies. Their adversaries claimed that business operations were better run by private companies, and that municipal takeovers would only mean a larger burden for the tax-payers. The debates on how to improve and extend the reach of public services articulated new notions of community. The daily lives of women, children and the urban poor became a contested issue, and a new field for political solutions. Eventually, a future-oriented discourse became dominant where the solutions for today were expected to solve the problems of tomorrow as well.

  • Högberg, Anders
    Linnéuniversitetet, Fakulteten för konst och humaniora (FKH), Institutionen för kulturvetenskaper (KV). University of Johannesburg, South Africa.
    Heritage Education, the Time Travel Method and Developments in Theory2018Inngår i: The Time Travel Method: in the Service of Society and its Development : Papers from the international seminar in Kalmar 28 February 2018 / [ed] Ebbe Westergren, Gustav Wollentz, Kalmar: Kalmar läns museum , 2018, s. 24-31Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Jacobsson, Martin
    et al.
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Wåhslén, Jonas
    KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Medicinteknik och hälsosystem, Hälsoinformatik och logistik.
    Virtual machine execution for wearables based on WebAssembly2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Today, the programming of a complete wearable sensor system requires writing code in different programming languages for the different parts of the systems, such as the wearable sensor platform itself, the gateway, the back-end server, and the client app. In this paper, we propose to use WebAssembly, which is a simple but powerful virtual machine standard already supported by all major web browsers. We show that it is possible to implement a WebAssembly interpreter for embedded systems, such as the Texas Instruments CC2652R system-on-chip and this enables the same code to execute in all parts of the systems. In our proof-of-concept implementation, we use Bluetooth low energy, which means that smartphones can communicate with and program our device without the need for special hardware.

  • Stenberg, Elin
    et al.
    Sveriges lantbruksuniversitet.
    Olsson, Viktoria
    Högskolan Kristianstad, Fakulteten för naturvetenskap, Forskningsmiljön Food and Meals in Everyday Life (MEAL). Högskolan Kristianstad, Fakulteten för naturvetenskap, Avdelningen för mat- och måltidsvetenskap.
    Wendin, Karin
    Högskolan Kristianstad, Fakulteten för naturvetenskap, Forskningsmiljön Food and Meals in Everyday Life (MEAL). Högskolan Kristianstad, Fakulteten för naturvetenskap, Avdelningen för mat- och måltidsvetenskap.
    Karlsson, Anders H.
    Sveriges lantbruksuniversitet.
    How four typical Swedish production systems for lambs affect sensory attributes of the meat2018Inngår i: 26th NJF Congress: agriculture for the Next 100 Years, 2018Konferansepaper (Annet vitenskapelig)
  • Khan, Zain Ahmed
    et al.
    KTH, Skolan för elektroteknik och datavetenskap (EECS), Teknisk informationsvetenskap.
    Zenteno, Efrain
    Universidad Católica San Pablo.
    Händel, Peter
    KTH, Skolan för elektroteknik och datavetenskap (EECS), Teknisk informationsvetenskap.
    Isaksson, Magnus
    University of Gävle.
    Extraction of the Third-Order 3x3 MIMO VolterraKernel Outputs Using Multitone Signals2018Inngår i: IEEE transactions on microwave theory and techniques, ISSN 0018-9480, E-ISSN 1557-9670Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This paper uses multitone signals to simplify theanalysis of 3×3 multiple-input multiple-output (MIMO) Volterrasystems by isolating the third-order kernel outputs from eachother. Multitone signals fed to an MIMO Volterra system yielda spectrum that is a permutation of the sums of the inputsignal tones. This a priori knowledge is used to design multitonesignals such that the third-order kernel outputs are isolated inthe frequency domain. The signals are designed by deriving theconditions for the offset and spacing of the input frequency grids.The proposed technique is then validated for the six possibleconfigurations of a 3x3 RF MIMO transmitter impaired bycrosstalk effects. The proposed multitone signal design is usedto extract the third-order kernel outputs, and their relativecontributions are analyzed to determine the dominant crosstalkeffects for each configuration.

  • Khan, Zain Ahmed
    et al.
    Högskolan i Gävle, Akademin för teknik och miljö, Avdelningen för elektronik, matematik och naturvetenskap, Elektronik. Department of Information Science and Engineering, KTH Royal Institute of Technology, Stockholm, Sweden.
    Zenteno, Efrain
    Universidad Católica San Pablo, Arequipa, Peru.
    Händel, Peter
    Department of Information Science and Engineering, KTH Royal Institute of Technology, Stockholm, Sweden.
    Isaksson, Magnus
    Högskolan i Gävle, Akademin för teknik och miljö, Avdelningen för elektronik, matematik och naturvetenskap, Elektronik.
    Extraction of the Third-Order 3x3 MIMO Volterra Kernel Outputs Using Multitone Signals2018Inngår i: IEEE transactions on microwave theory and techniques, ISSN 0018-9480, E-ISSN 1557-9670Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This paper uses multitone signals to simplify the analysis of 3×3 multiple-input multiple-output (MIMO) Volterra systems by isolating the third-order kernel outputs from each other. Multitone signals fed to an MIMO Volterra system yield a spectrum that is a permutation of the sums of the input signal tones. This a priori knowledge is used to design multitone signals such that the third-order kernel outputs are isolated in the frequency domain. The signals are designed by deriving the conditions for the offset and spacing of the input frequency grids. The proposed technique is then validated for the six possible configurations of a 3x3 RF MIMO transmitter impaired by crosstalk effects. The proposed multitone signal design is used to extract the third-order kernel outputs, and their relative contributions are analyzed to determine the dominant crosstalk effects for each configuration.

  • Morshed, Sarwar J.
    et al.
    Linnéuniversitetet, Fakulteten för teknik (FTK), Institutionen för datavetenskap och medieteknik (DM).
    Rana, Juwel
    Linnéuniversitetet, Fakulteten för teknik (FTK), Institutionen för datavetenskap och medieteknik (DM). Telenor Group, Norway.
    Milrad, Marcelo
    Linnéuniversitetet, Fakulteten för teknik (FTK), Institutionen för datavetenskap och medieteknik (DM).
    Active and Satisfied Users as a Key to Measure the Success of a Digital Mobile Service2018Inngår i: Proceedings 6th Artificial Intelligence for Knowledge Management (AI4KM), Stockholm, Sweden / [ed] Eunika Mercier-Laurent, Mieczysław L. Owoc, Nada Matta, Oliver Obst, 2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    In order to develop, deploy and sustain a digital mobile service attractive to the users, one of the key parameters is to understand and to identify the satisfied users of such service and to maintain a user satisfaction-centric knowledge management. The classical way of achieving this is to collect users´ direct or indirect feedback and to measure their level of satisfaction. Digital mobile services have a global focus and address global audiences - which means getting users´ feedback and finding users´ satisfaction by performing studies using questionnaire for millions of users. Such an approach cannot be the most efficient way for doing so. This paper proposes an alternative approach of using data science knowledge and techniques, which performs a prediction on the usage data to distinguish between satisfactory and unsatisfactory users at a different level of granularity. First of all, this model generates some common predictors from users' access log data through descriptive analysis. Later, these predictive variables are used to predict the level of user satisfaction using Machine Learning Algorithms. Using this user-centric knowledge management model, digital service providers could measure whether their offered services would reach success by predicting the number of satisfied users.

  • Ceccato, Vania
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Segurança e mercado imobiliário urbano2017Inngår i: Novas perspectivas analiticas e interprepativas da Ciencia geografica no atual contexto do sistema mundo / [ed] Antonio Carlos Vitte, Campinas: Paco editorial , 2017Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [pt]

    Esse capítulo começa revelando o efeito da (in)segurança no mercado imobiliário usando como base estudos com modelos de precos hedônicos na literatura internacional e na Brasileira. Ele também discute como o crime e a falta de seguranca são o topo do icerberg de outros dinamicas estruturais urbanas que diretamente afetam a disposicao dos individuos em pagar ou não por uma propriedade. Assumindo uma agenda de pesquisa interdisciplinar, entre os campos da Economia, Geografia e Criminologia, o capítulo finaliza identificando uma serie de questões urgentes serem tratadas em pesquisa futura.

  • Ceccato, Vania
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö.
    Wilhelmsson, Mats
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Fastigheter och byggande.
    Does crime impact real estate prices? An assessment of accessibility and location12018Inngår i: Oxford Handbook on Environmental Criminology / [ed] Gerben J.N. Bruinsma and Shane D. Johnson, Oxford University Press, 2018Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    Properties located in areas with good accessibility tend to be highly valued in the housing market. Yet, good accessibility may also mean more social interaction, consequently more crime, which under certain circumstances pulls housing prices down. In this study, we assess the impact on housing prices of crime mediated by accessibility. The coordinates of properties sold in the Stockholm metropolitan area are combined in a database with the characteristics of each property and its neighborhood, including burglary rates. After accounting for the possible endogeneity of crime and housing attributes, findings confirm that burglary reduces housing prices. In particular, in a location far from the central business district, regardless of accessibility, residential burglary has a negative impact on apartment prices. However, for apartments in areas with relatively good accessibility near the central business district, burglary has no effect on prices, while for apartments in areas with poor accessibility, burglary helps reduce prices.

  • Ceccato, Vania
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Wiebe, Douglas
    Eshraghi, Bita
    Vrotsou, Katerina
    Women’s Mobility and the Situational Conditions of Rape: Cases Reported to Hospitals2017Inngår i: Journal of Interpersonal Violence, ISSN 0886-2605, E-ISSN 1552-6518Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    third of all rapes in Stockholm, the capital of Sweden, take place in

    public outdoor places. Yet, little is known about the events that precede

    this type of sexual offence and less about the situational context of rape.

    This study aims to improve the understanding of the nature of situational

    conditions that immediately precede events of rape. Using medical records

    of 147 rape victims during 2012 and 2013, we constructed time- and

    place-specific records of the places women traveled through or spent

    time at, the activities they engaged in, and the people they interacted

    with sequentially over the course of the day when they were raped.

    The analysis uses visualization tools (VISUAL-TimePAcTS), Geographical

    Information Systems, and conditional logistic regression to identify place-,

    context-, and social interaction–related factors associated with the onset

    of rape. Results for this sample of cases reported to hospitals show that

    being outdoors was not necessarily riskier for women when compared

    with indoor public settings; some outdoor environments were actually

    protective, such as streets. Being in a risky social context and engaging in

    a risky activity before the event was associated with an increased risk of

    rape, and the risk escalated over the day. Among those women who never

    drank alcohol, the results were similar to what was observed in the overall

    sample, which suggests that risky social interaction and risky activity made

    independent contributions to the risk of rape. The article finishes with

    suggestions for rape prevention.

  • Ceccato, Vania
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Armitage, Rachel
    Practical Challenges and New Research Frontiers in Retail Crime and Its Prevention2018Inngår i: Retail Crime: International Evidence and Prevention / [ed] Vania Ceccato and Rachel Armitage, Cham: Palgrave Macmillan, 2018Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [en]

    This final chapter is composed of four parts: a summary of the results, the cross-cutting common themes, the book limitations and a future research agenda linked to policy recommendations. This chapter first synthesises and critically reviews the key findings, identifying relevant challenges and lessons learnt by contributors that come from a variety of backgrounds. Then, it outlines the future research in retail crime and provides a number of suggestions for policy recommendations that are linked to different retail issues.

  • Ceccato, Vania
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Guangquan, Li
    Haining, Robert
    The ecology of outdoor rape: The case of Stockholm,Sweden2018Inngår i: European Journal of Criminology, ISSN 1477-3708, E-ISSN 1741-2609Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The objective of this article is to report the results of an ecological study into the geography of rape in Stockholm, Sweden, using small area data. In order to test the importance of factors indicating opportunity, accessibility and anonymity to the understanding of the geography of rape, a two-stage modelling approach is implemented. First, the overall risk factors associated with the occurrence of rape are identified using a standard Poisson regression, then a local analysis using profile regression is performed. Findings from the whole-map analysis show that accessibility,

    opportunity and anonymity are all, to different degrees, important in explaining the overall

    geography of rape - examples of these risk factors are the presence of subway stations or whether

    a

    basområde is close to the city centre. The local analysis reveals two groupings of high risk of

    rape areas associated with a variety of risk factors:

    city centre areas with a concentration of alcohol

    outlets, high residential population turnover and high counts of robbery; and

    poor suburban areas

    with schools and large female residential populations where subway stations are located and where

    people express a high fear of crime. The article concludes by reflecting upon the importance of these results for future research as well as indicating the implications of these results for policy

  • Ceccato, Vania
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Crime in transit environments: Lessons from Stockholm (Sweden) and São Paulo (Brazil) metro systems: 交通环境犯罪:从瑞典斯德哥尔摩和巴西圣保罗地铁系统的经验总结2018Inngår i: Landscape Architecture, Vol. 7Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [zh]

    笔者通过评估瑞典斯德哥尔摩和巴西圣保罗地铁系统的犯罪活动及扰乱公共秩序行为案例,探讨相关经 验教训。对比 2 个国家地铁系统的时空犯罪模式及上述案例的研究结果,总结环境对犯罪活动及扰乱公共秩序行为的影响。研究中地理信息系统、田野调查和建模等分析过程应用了相应地铁运营商的基础数据。研究发现 市中心地铁站及终点站往往比其他站点更容易发生犯罪。除了区位因素,地铁站的环境属性、周边环境及社区 环境也会影响站点的犯罪机会。预防犯罪的干预措施必须针对具体犯罪活动、核心地铁站的拥挤情况,特别是 易发生犯罪的高峰时段制定。以此总结今后相关研究方向,并提出相应政策建议。

  • Ceccato, Vania
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Melo, Silas N.
    Kahn, Tulio
    Trends and Patterns of Police-Related Deaths in Brazil2017Inngår i: The Palgrave Handbook of Criminology and the Global South / [ed] Kerry Carrington, Russell Hogg, John Scott, Máximo Sozzo, Palgrave Macmillan, 2017Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [en]

    This chapter focuses on civilian deaths at the hands of, and in confrontation

    with, the police, often (but not necessarily) after, or in combination with,

    a potential or suspected ongoing crime using an average rate of data from

    2013 to 2014. The chapter builds on the most recent literature of police-related

    deaths in Brazil and relies on new data to characterize trends and the

    geography of police-related deaths in Brazil from two complementary sources.

    The chapter also identifies state-level covariates that help interpret the regional

    variation of rates of police killings against a set of hypotheses drawing from

    two branches of criminological theory.

  • Ceccato, Vania
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Fear of crime and overall anxieties in rural areas: The case of Sweden2018Inngår i: The Routledge International Handbook on Fear of Crime / [ed] Murray Lee, Gabe Mythen, Routledge, 2018, 1Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [en]

    Fear of crime is not typically considered a conventional policing matter and seems to be even less of an issue in rural communities, where crime rates are generally lower than in urban areas. One reason for this is that the police, as well as those who devote their time to crime prevention and policing, often work reactively, requiring an offense to be committed before any action can be taken. Another problem is that fear (of crime) may be triggered by the trauma of victimisation, though that is not its only source. Anxieties are fed by multi-scale factors, which make fear a difficult issue to be tackled as a policing matter. Despite a vast literature on fear (Box et al. 1988; Ceccato  2012; Ferraro  1995; Gray  et  al.  2008; Hale  1996; Hummelsheim  et  al.  2010;  Jackson and Gouseti 2012; Jonathan  Jackson and Gray 2010; Lagrange and Ferraro 1989; Murray 2007, 2011), relatively little focus has been given to the nuances of fear in rural contexts (but see e.g. Scott et al. 2012; Panelli et al. 2004; Ceccato 2016; Lee 2007).The aim of this chapter is to discuss the nature of fear of crime by placing it in a broadercontext using Swedish rural areas as a case study. This goal is achieved by first portraying  “the big picture” of fear of crime in rural areas, namely by discussing fear of crime and other overall anxieties as captured by official fear of crime indicators from living conditions and crime vic- timisation surveys. Then, beyond the statistics of perceived safety, the chapter sheds light on the nature of fear by focusing on particular groups in Swedish rural areas: the farmers, the Sami youngadults and local residents in relation to temporary newcomers, the ‘berry pickers’.

  • Ceccato, Vania
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Armitage, Rachel
    Retail Crime: Aim, Scope, Theoretical Framework and Definitions2018Inngår i: Retail crime: International Evidence and Prevention / [ed] Vania Ceccato and Rachel Armitage, Cham: Palgrave Macmillan, 2018, 1Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Ceccato, Vania
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Tcacencu, Sanda
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Perceived Safety in a Shopping Centre: A Swedish Case Study2018Inngår i: Retail crime / [ed] Vania Ceccato and Rachel Armitage, Cham: Palgrave Macmillan, 2018, s. 215-242Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    The aim of this study is twofold. Firstly, it is to assess the declared perceived

    safety of visitors in relation to their personal characteristics as well

    as to the environment of the shopping mall. Based on this assessment, the

    study proposes changes to improve shopping centres’ safety conditions.

  • Ceccato, Vania
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Falk, Örjan
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Fastigheter och byggande.
    Parsanezhad, Pouriya
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Fastigheter och byggande.
    Tarandi, Väino
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Fastigheter och byggande.
    Crime in a Scandinavian Shopping Centre2018Inngår i: Retail crime / [ed] Vania Ceccato and Rachel Armitage, Cham: Palgrave Macmillan, 2018, 1, s. 179-203Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    he aim of this chapter is to understand the nature of crime in space and time in a shopping centre and provide suggestions for safety improvements drawing from principles of Crime Prevention Through Environmental Design (CPTED). The study makes use of data registered by the security companies and three-dimensional visualisation using BIM (Building information modelling) to detect areas that run higher risk of crime using a shopping centre in Stockholm Sweden. Based on an extensive fieldwork inspection, the study assesses whether and how spatial and temporal concentrations of crime relate to particular features of the shopping environment. Finally, the chapter indicates the types of environments that are most in need of safety intervention.

     

  • Ceccato, Vania
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Patterns of Traffic Accidents Among Elderly Pedestrians in Sweden2018Inngår i: Review of European Studies, ISSN 1918-7173, E-ISSN 1918-7181, Vol. 10, nr 3, s. 117-133Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The objective of this study is to characterize the nature and space-time patterns of traffic accidents involving elderly pedestrians in Sweden, in order to suggest preventive measures. The analysis is based on elderly pedestrian accidents from 2010 to 2014 using an age adjusted standardized elderly accidents ratios (ASEAR), Geographical Information Systems (GIS) and spatial statistics techniques. Findings show that the geography of elderly traffic accidents is far from being homogenous across the country: although most accidents happen in urban municipalities, 30 per cent of municipalities classified as accessible rural exhibit relatively high-standardized accidents ratios. They happen often in daylight hours, on weekdays and in the coldest months of the year. Most of the cases are single accidents (e.g. self-inflicted fall); they happen in street segments/intersections and pedestrian/bicycle path, some affected by environment conditions such as icy or uneven surfaces. Findings of the study call for preventive actions that are sensitive to the nature of these accidents in different temporal and spatial contexts.

  • Ceccato, Vania
    et al.
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Samhällsplanering och miljö, Urbana och regionala studier.
    Nyberg, Ulla-Karin
    Vrotsou, Katerina
    Wiebe, Douglas
    Berglund, Arne
    Situationsförhållanden vid suicid på tågplattformar: En analys med hjälp av material från övervakningskameror (CCTV)2018Rapport (Annet vitenskapelig)
    Abstract [en]

    Självmord är ett allvarligt folkhälsoproblem. Varje år sker omkring 1100 konstaterade suicid i Sverige och uppskattningsvis sker cirka 10 % av samtliga fall inom transitsystemet. Under åren 2012–2014 skedde i genomsnitt 95 fall av suicid per år enbart inom järnvägs- och tunnelbanesystemet. Förutom förlust av liv eller allvarliga skador medför självmord i transportmiljöer höga kostnader till följd av trauma för förare och vittnen samt serviceförseningar. Forskning visar att begränsning av medel och metoder är en insatstyp som kan minska suicid. Denna studie syftar till att undersöka möjligheten att använda inspelat material (film och bild) från övervakningskameror (CCTV) vid tunnelbane- och pendeltågsstationer runt om i Stockholm för att ta fram fördjupad kunskap om händelseförloppet som leder fram till en suicidal handling. Inom ramen för studien analyserade och kategoriserade vi situationer och förhållanden runt suicid som sker i tunnelbane- och pendeltågstationer. Genom ökad kunskap om dessa situationer är tanken att kunna bidra med underlag till utformningen av lämpliga förebyggande åtgärder.

    Studien har finansierats av Folkhälsomyndigheten genom uppdraget att vara nationell samordnande myndighet för arbetet med att förebygga suicid på nationell nivå. Författarna är Vania Ceccato (KTH) i samarbetet med Ulla-Karin Nyberg (SLL), Katerina Vrotsou (Linköping universitet), Douglas Wiebe (Pennsylvania University) och Arne Grundberg (SL).

     

  • Lundström, Niklas L. P.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för matematik och matematisk statistik.
    How to find simple nonlocal stability and resilience measures2018Inngår i: Nonlinear dynamics, ISSN 0924-090X, E-ISSN 1573-269X, Vol. 93, nr 2, s. 887-908Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Stability of dynamical systems is a central topic with applications in widespread areas such as economy, biology, physics and mechanical engineering. The dynamics of nonlinear systems may completely change due to perturbations forcing the solution to jump from a safe state into another, possibly dangerous, attractor. Such phenomena cannot be traced by the widespread local stability and resilience measures, based on linearizations, accounting only for arbitrary small perturbations. Using numerical estimates of the size and shape of the basin of attraction, as well as the systems returntime to the attractor after given a perturbation, we construct simple nonlocal stability and resilience measures that record a systems ability to tackle both large and small perturbations. We demonstrate our approach on the Solow-Swan model of economic growth, an electro-mechanical system, a stage-structured population model as well as on a high-dimensional system, and conclude that the suggested measures detect dynamic behavior, crucial for a systems stability and resilience, which can be completely missed by local measures. The presented measures are also easy to implement on a standard laptop computer. We believe that our approach will constitute an important step toward filling a current gap in the literature by putting forward and explaining simple ideas and methods, and by delivering explicit constructions of several promising nonlocal stability and resilience measures.

  • Garvin, Stina
    et al.
    Oda, Husam
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi. Department of Pathology, County Hospital Ryhov, Jönköping, Sweden.
    Arnesson, Lars-Gunnar
    Lindström, Annelie
    Shabo, Ivan
    Tumor cell expression of CD163 is associated to postoperative radiotherapy and poor prognosis in patients with breast cancer treated with breast-conserving surgery2018Inngår i: Journal of Cancer Research and Clinical Oncology, ISSN 0171-5216, E-ISSN 1432-1335, Vol. 144, nr 7, s. 1253-1263Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Cancer cell fusion with macrophages results in highly tumorigenic hybrids that acquire genetic and phenotypic characteristics from both maternal cells. Macrophage traits, exemplified by CD163 expression, in tumor cells are associated with advanced stages and poor prognosis in breast cancer (BC). In vitro data suggest that cancer cells expressing CD163 acquire radioresistance. Tissue microarray was constructed from primary BC obtained from 83 patients treated with breast-conserving surgery, 50% having received postoperative radiotherapy (RT) and none of the patients had lymph node or distant metastasis. Immunostaining of CD163 in cancer cells and macrophage infiltration (MI) in tumor stroma were evaluated. Macrophage:MCF-7 hybrids were generated by spontaneous in vitro cell fusion. After irradiation (0, 2.5 and 5 Gy gamma-radiation), both hybrids and their maternal MCF-7 cells were examined by clonogenic survival. CD163-expression by cancer cells was significantly associated with MI and clinicopathological data. Patients with CD163-positive tumors had significantly shorter disease-free survival (DFS) after RT. In vitro generated macrophage:MCF-7 hybrids developed radioresistance and exhibited better survival and colony forming ability after radiation compared to maternal MCF-7 cancer cells. Our results suggest that macrophage phenotype in tumor cells results in radioresistance in breast cancer and shorter DFS after radiotherapy.

  • Willers, Carl
    et al.
    Iderberg, Hanna
    Axelsen, Mette
    Dahlström, Tobias
    Julin, Bettina
    Leksell, Janeth
    Lindberg, Agneta
    Lindgren, Peter
    Muth, Karin Loostrom
    Svensson, Ann-Marie
    Lilja, Mikael
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Sociodemographic determinants and health outcome variation in individuals with type 1 diabetes mellitus: A register-based study2018Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 6, artikkel-id e0199170Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Socioeconomic status, origin or demographic attributes shall not determine the quality of healthcare delivery, according to e.g. United Nations and European Union rules. Health equity has been defined as the absence of systematic disparities and unwarranted differences between groups defined by differences in social advantages. A study was performed to investigate whether this was applicable to type 1 diabetes mellitus (T1D) care in a setting with universal, tax-funded healthcare. Methods: This retrospective registry-study was based on patient-level data from individuals diagnosed with T1D during 2010-2011 (n = 16,367) in any of seven Swedish county councils (covering -65% of the Swedish population). Health equity in T1D care was analysed through multivariate regression analyses on absolute HbA1c level at one-year follow-up, one-year change in estimated glomerular filtration rate (eGFR) and one-year change in cardiovascular risk score, using selected sociodemographic dimensions as case-mix factors. Results: Higher educational level was consistently associated with lower levels of HbA1c, and so was being married. Never married was associated with worse eGFR development, and lower educational level was associated with higher cardiovascular risk. Women had higher HbA1c levels than men, and glucose control was significantly worse in patients below the age of 25. Conclusion: Patients' sociodemographic profile was strongly associated with absolute levels of risk factor control in T1 D, but also with an increased annual deterioration in eGFR. Whether these systematic differences stem from patient-related problems or healthcare organisational shortcomings is a matter for further research. The results, though, highlight the need for intensified diabetes management education and secondary prevention directed towards T1D patients, taking sociodemographic characteristics into account.

  • Mandel, Anna
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten).
    Larsson, Per
    Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten).
    Sarwar, Martuza
    Semenas, Julius
    Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten).
    Khaja, Azharuddin Sajid Syed
    Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten).
    Persson, Jenny L.
    Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten).
    The interplay between AR, EGF receptor and MMP-9 signaling pathways in invasive prostate cancer2018Inngår i: Molecular medicine (Cambridge, Mass. Print), ISSN 1076-1551, E-ISSN 1528-3658, Vol. 24, s. 1-13, artikkel-id UNSP 34Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Metastatic Prostate cancer (PCa) cells have gained survival and invasive advantages. Epidermal growth factor (EGA) receptor is a receptor tyrosine kinase, which may mediate signalling to promote progression and invasion of various cancers. In this study, we uncovered the molecular mechanisms underlying the interconnection among the androgen receptor (AR), matrix metalloproteinase-9 (MMP9) and EGFR in promoting PCa progression. Methods: Immunohistochemical analysis of the tissue microarrays consisting of primary and metastatic PCa tissues was performed. The clinical importance of EGFR and its association with survivals were analyzed using three cohorts from MSKCC Prostate Oncogenome Project dataset (For primary tumors, n = 181; for metastatic tumors n = 37) and The Cancer Genome Atlas Prostate Adenocarcinoma Provisional dataset (n = 495). Targeted overexpression or inhibition of the proteins of interests was introduced into PCa cell lines. Treatment of PCa cell lines with the compounds was conducted. Immunoblot analysis was performed. Results: We showed that AR, MMP-9 and EGFR are interconnect factors, which may cooperatively promote PCa progression. Altered EGFR expression was associated with poor disease-free survival in PCa patients. Induced overexpression of AR led to an increase in the expression of EGFR, p-GSK-313 and decrease in p27 expression in PCa cell lines in the presence of androgen stimulation. Overexpression of MMP9 significantly induced EGFR expression in PCa cells. Inhibition of PIP5K1a, a lipid kinase that acts upstream of PI3K/AKT greatly reduced expressions of AR, MMP-9 and EGFR. Conclusions: Our findings also suggest that PCa cells may utilize AR, EGFR and MMP-9 pathways in androgen-dependent as well as in castration-resistant conditions. Our data suggest a new therapeutic potential to block cancer metastasis by targeting AR, EGFR and MMP-9 pathways in subsets of PCa patients.

  • Adlard, B.
    et al.
    Donaldson, S. G.
    Odland, J. O.
    Weihe, P.
    Berner, J.
    Carlsen, A.
    Bonefeld-Jorgensen, E. C.
    Dudarev, A. A.
    Gibson, J. C.
    Krümmel, E. M.
    Olafsdottir, K.
    Abass, K.
    Rautio, A.
    Bergdahl, Ingvar A.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Mulvad, G.
    Future directions for monitoring and human health research for the Arctic Monitoring and Assessment Programme2018Inngår i: Global Health Action, ISSN 1654-9716, E-ISSN 1654-9880, Vol. 11, nr 1, artikkel-id 1480084Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    For the last two and a half decades, a network of human health experts under the Arctic Monitoring and Assessment Program (AMAP) has produced several human health assessment reports. These reports have provided a base of scientific knowledge regarding environmental contaminants and their impact on human health in the Arctic. These reports provide scientific information and policy-relevant recommendations to Arctic governments. They also support international agreements such as the Stockholm Convention on Persistent Organic Pollutants (POPs) and the Minamata Convention on Mercury. Key topics discussed in this paper regarding future human health research in the circumpolar Arctic are continued contaminant biomonitoring, health effects research and risk communication. The objective of this paper is to describe knowledge gaps and future priorities for these fields.

  • Du, Xiaoyang
    et al.
    Khamitova, Adina
    Kyhlstedt, Mattias
    Sun, Sun
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa. Department of Learning, Information, Management and Ethics, Karolinska Institutet, Stockholm, Sweden; Synergus AB, Stockholm, Sweden.
    Sengoelge, Mathilde
    Utilisation of real-world data from heart failure registries in OECD countries: a systematic review2018Inngår i: IJC Heart & Vasculature, ISSN 2352-9067, Vol. 19, s. 90-97Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Background: Heart failure represents a major public health issue that impacts 26 million people globally. Currently, real-world data represents a key instrument for providing the verification of both internal and external validity, yet there is still a lack of understanding regarding its scope in complementing evidence of treatments for heart failure. This study aims to increase understanding of the utilisation of real-word data from heart failure registries in Organisation for Economic Co-operation and Development (OECD) countries.

    Method: This was a systematic review of existing observational studies from heart failure registries in 35 OECD member countries. Studies from 2000 to March 2017 were identified through electronic databases (MEDLINE (Ovid), EMBASE, Web of Science Core Collection, CINAHL (Ebsco), Cochrane CENTRAL) and appraised according to eligibility criteria.

    Results: Two-hundred and two studies met the inclusion criteria, in which the majority were published from 2013 to 2016. All 202 studies were observational, among which 98% were cohort studies (198). The median sample size of all studies was 5152 (2417 to 32,890) and median study period 55 months (33.0 to 72.0). Swedish heart failure registry had the most publications (24, 12%).

    Conclusion: Since 2000 there has been an upward trend in the number of published observational studies on heart failure registries in OECD countries with increasingly diverse outcomes and advanced statistical methods to improve their validity and reliability. This indicates that the utilisation of real-world data has experienced a significant upsurge in complementing the findings of clinical trials for improved research of heart failure treatments.

  • Peterson, Gunnel
    et al.
    Nilsson, David
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Trygg, Johan
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Peolsson, Anneli
    Neck-specific exercise improves impaired interactions between ventral neck muscles in chronic whiplash: A randomized controlled ultrasound study2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 9649Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Chronic pain and disability is common in whiplash-associated disorders (WAD), leading to personal suffering, sick leave, and social cost. The cervical spine is heavily dependent on muscular support and whiplash injury can cause damage to the neck muscles, but diagnostic tools to measure neck muscle impairment and evaluate exercise interventions are lacking. Therefore, the present study investigated ventral neck muscle interactions in 26 individuals with chronic WAD randomized to neck-specific exercise (NSE) or remaining on a waiting list (WL) in 3 months. We performed real-time, non-invasive ultrasound measurements with speckle tracking analysis and calculated the deformation area and deformation rate in three ventral neck muscles. Multivariate statistics were used to analyse interactions between the muscles. After 3 months of NSE, significant improvements were observed in neck muscle interactions and pain intensity in the NSE group compared to the WL group. Thus, this study demonstrates that non-invasive ultrasound can be a diagnostic tool for muscle impairment and used to evaluate exercise interventions in WAD and stands to make a breakthrough for better management in chronic WAD.

  • Gösweiner, Christian
    et al.
    Lantto, Perttu
    Fischer, Roland
    Sampl, Carina
    Umut, Evrim
    Westlund, Per-Olof
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Kruk, Danuta
    Bödenler, Markus
    Spirk, Stefan
    Petrovič, Andreas
    Scharfetter, Hermann
    Tuning Nuclear Quadrupole Resonance: A Novel Approach for the Design of Frequency-Selective MRI Contrast Agents2018Inngår i: Physical Review X, ISSN 2160-3308, E-ISSN 2160-3308, Vol. 8, nr 2, artikkel-id 021076Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The interaction between water protons and suitable quadrupolar nuclei (QN) can lead to quadrupole relaxation enhancement (QRE) of proton spins, provided the resonance condition between both spin transitions is fulfilled. This effect could be utilized as a frequency selective mechanism in novel, responsive T-1 shortening contrast agents (CAs) for magnetic resonance imaging (MRI). In particular, the proposed contrast mechanism depends on the applied external flux density-a property that can be exploited by special field-cycling MRI scanners. For the design of efficient CA molecules, exhibiting narrow and pronounced peaks in the proton T-1 relaxation dispersion, the nuclear quadrupole resonance (NQR) properties, as well as the spin dynamics of the system QN-H-1, have to be well understood and characterized for the compounds in question. In particular, the energy-level structure of the QN is a central determinant for the static flux densities at which the contrast enhancement appears. The energy levels depend both on the QN and the electronic environment, i.e., the chemical bonding structure in the CA molecule. In this work, the NQR properties of a family of promising organometallic compounds containing Bi-209 as QN have been characterized. Important factors like temperature, chemical structure, and chemical environment have been considered by NQR spectroscopy and ab initio quantum chemistry calculations. The investigated Bi-aryl compounds turned out to fulfill several crucial requirements: NQR transition frequency range applicable to clinical 1.5- and 3 T MRI systems, low temperature dependency, low toxicity, and tunability in frequency by chemical modification.

  • Lundström, Ronnie
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper. Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Baloch, Adnan Noor
    Hagberg, Mats
    Nilsson, Tohr
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Gerhardsson, Lars
    Long-term effect of hand-arm vibration on thermotactile perception thresholds2018Inngår i: Journal of Occupational Medicine and Toxicology, ISSN 1745-6673, E-ISSN 1745-6673, Vol. 13, artikkel-id 19Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Occupational exposure to hand-transmitted vibration (HTV) is known to cause neurological symptoms such as numbness, reduced manual dexterity, grip strength and sensory perception. The purpose of this longitudinal study was to compare thermotactile perception thresholds for cold (TPTC) and warmth (TPTW) among vibration exposed manual workers and unexposed white collar workers during a follow-up period of 16 years to elucidate if long-term vibration exposure is related to a change in TPT over time. Methods: The study group consisted of male workers at a production workshop at which some of them were exposed to HTV. They were investigated in 1992 and followed-up in 2008. All participants were physically examined and performed TPT bilaterally at the middle and distal phalanges of the second finger. Two different vibration exposure dosages were calculated for each individual, i.e. the individual cumulative lifetime dose (mh/s2) or a lifetime 8-h equivalent daily exposure (m/s(2)). Results: A significant mean threshold difference was found for all subjects of about 4-5 degrees C and 1-2 degrees C in TPTW and TPTC, respectively, between follow-up and baseline. No significant mean difference in TPTC between vibration exposed and non-exposed workers at each occasion could be stated to exist. For TPTW a small but significant difference was found for the right index finger only. Age was strongly related to thermotactile perception threshold. The 8-h equivalent exposure level (A (8)) dropped from about 1.3 m/s2 in 1992 to about 0.7 m/s(2) in 2008. Conclusions: A lifetime 8-h equivalent daily exposure to hand-transmitted vibration less than 1.3 m/s(2) does not have a significant effect on thermotactile perception. Age, however, has a significant impact on the change of temperature perception thresholds why this covariate has to be considered when using TPT as a tool for health screening.

  • Magnusson, Lars
    Linnéuniversitetet, Fakulteten för teknik (FTK), Institutionen för informatik (IK).
    Accesskontroll som nyckel till bättre IT-säkerhet2013Inngår i: Bonniers IT-managementhandbok / [ed] Tord Schultz, Lars Hornborg, Eva Fredriksson, Stockholm: Bonnier, 2013, 10Kapittel i bok, del av antologi (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Modern IT ställer högre krav på access/autentiseringsprocesserna, denna artikel debaterar dessa i relation till HRs ansvar att signalera förändringar i anställningar. 

  • Magnusson, Lars
    Linnéuniversitetet, Fakulteten för teknik (FTK), Institutionen för informatik (IK).
    A New Authentication Paradigm?2012Inngår i: ISC2 InfoSecurity Professional Magazine, ISSN -, Vol. 3, nr 17, s. 24-24Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A discussion piece regarding early 2010 woes and concerns about authentication of cloud service users and the information security aspects of that.  Includes a perspective of authentication  in the view of AT&T Plan 9 Factorum security service. 

  • Magnusson, Lars
    Linnéuniversitetet, Fakulteten för teknik (FTK), Institutionen för informatik (IK).
    HR Access: a key to better InfoSecurity2013Inngår i: ISC2 InfoSecurity Professional Magazine, ISSN -, Vol. 4, nr 22, s. 23-23Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    As seen in virtually all IT audits, the auditors find active accounts connected to people retired, that left the organization or simply change jobs. Accounts that should be closed. THise article is a discussion about forcing the HR department to give IT better signals of personnel changes, so IT does not need to rely on personal knowledge.  The issue is a key US SOX finding and will be an EU GDPR key finding in GDPR audits.

  • Magnusson, Lars
    Linnéuniversitetet, Fakulteten för teknik (FTK), Institutionen för informatik (IK).
    12.3 Informationssäkerhet på 2010-talet2013Inngår i: Bonniers IT-managementhandbok / [ed] Tord Schultz, Lars Hornborg, Eva Fredriksson, Stockholm: Bonnier, 2013, 10Kapittel i bok, del av antologi (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Artikeln går igenom de informationsäkerhetsutmaningar vi står inför under 2010-talet, både tekniskt som processmässigt. Bland annat beskrivs vikten av revisioner och regelverk, samt hur bygga upp en säkerhetspolicy.

  • Herschend, Frands
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för arkeologi och antik historia, Arkeologi.
    How Norse is Skírnismál?: A comparative case study2018Inngår i: Journal of Archaeology and Ancient History (JAAH), E-ISSN 2001-1199, nr 23Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Venantius Fortunatus was a Latin, Ravenna educated, semi-political rhetorical poet active in Merovingian Francia in the late 6th century. Arriving in Austrasia from the Alps in the spring of 566, he wrote three poems, not least an epithalamium publicly performed at the wedding of Sigibert and Brunhild. This literary genre, its structure and the three addressees of his poems can be seen as a surprisingly detailed template for the Norse poem Skírnismál. The value of Fortunatus’ poetry rests with his ability to amalgamate Germanic, Christian and Latin Roman culture in a period of transition from a pagan to a Christian society. Since these periods of transition are reoccurring, it is possible to see an education in the 10th–11th century as the background for the Norse Skírnismál author, who probably must have read Fortunatus in order to compose his Norse wedding entertainment. Skírnismál is thus neither a purely Norse nor a purely oral composition.

  • Dei, Vincent
    et al.
    San Sebastian, Miguel
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    Is healthcare really equal for all?: Assessing the horizontal and vertical equity in healthcare utilisation among older Ghanaians2018Inngår i: International Journal for Equity in Health, ISSN 1475-9276, E-ISSN 1475-9276, Vol. 17, artikkel-id 86Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: There is a lack of focused research on the older population in Ghana and about issues pertaining to their access to healthcare services. Furthermore, information is lacking regarding the fairness in the access to these services. This study aimed to ascertain whether horizontal and vertical equity requirements were being met in the healthcare utilisation among older adults aged 50 years and above. Methods: This study was based on a secondary cross-sectional data from the World Health Organization's Study on global AGEing (SAGE) and adult health wave 1 conducted from 2007 to 2008 in Ghana. Data on 4304 older adults aged 50 years-plus were analysed. Bivariate and multivariable analyses were carried out to analyse the association between outpatient/inpatient utilisation and (1) socioeconomic status (SES), controlling for need variables (horizontal equity) and (2) need variables, controlling for SES (vertical equity). Odds ratios with 95% confidence intervals were calculated to analyse the association between relevant variables. Results: Horizontal and vertical inequities were found in the utilisation of outpatient services. Inpatient healthcare utilisation was both horizontally and vertically equitable. Women were found to be more likely to use outpatient services than men but had reduced odds of using inpatient services. Possessing a health insurance was also significantly associated with the use of both inpatient and outpatient services. Conclusion: Whilst equity exists in inpatient care utilisation, more needs to be done to achieve equity in the access to outpatient services. The study reaffirms the need to evaluate both the horizontal and vertical dimensions in the assessment of equity in healthcare access. It provides the basis for further research in bridging the healthcare access inequity gap among older adults in Ghana.

  • Pérez-Urdiales, Iratxe
    et al.
    Goicolea, Isabel
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    ¿Cómo acceden las mujeres inmigrantes a los servicios sanitarios en el País Vasco?: Percepciones de profesionales sanitarias2018Inngår i: Atención Primaria, ISSN 0212-6567, E-ISSN 1578-1275, Vol. 50, nr 6, s. 368-376Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [es]

    Objetivo: Explorar la percepción de las profesionales sanitarias que trabajan en centros sanitarios alternativos sobre las barreras y los facilitadores en el acceso de las mujeres inmigrantes a los servicios sanitarios públicos generales y de salud sexual y reproductiva en el País Vasco.

    Emplazamiento: País Vasco.

    Diseño: Análisis de contenido cualitativo basado en 11 entrevistas individuales.

    Participantes: Profesionales sanitarias que trabajan en centros sanitarios alternativos de atención primaria y salud sexual y reproductiva.

    Método: La recolección de datos se realizó entre septiembre y diciembre de 2015 en cuatro centros sanitarios alternativos. Tras su transcripción, se identificaron unidades de significado, códigos y categorías.

    Resultados: Del análisis emergieron cuatro categorías que representan cómo las características de las mujeres inmigrantes (Dime cómo eres y te diré cómo accedes), la actitud del personal administrativo y sanitario («Cuando ya les atienden, estupendamente. El problema está con los administrativos»), el funcionamiento del sistema sanitario (Sistema de salud inflexible, pasivo y receptor de necesidades) y las políticas sanitarias («Si no cumples los requisitos, pues no entras. La ley es la ley») influyen en el acceso a los servicios sanitarios públicos de las mujeres inmigrantes.

    Conclusiones: Este estudio indica que hay un considerable número de barreras y pocos facilitadores en el acceso de las mujeres inmigrantes a los servicios sanitarios públicos y de salud sexual y reproductiva en el País Vasco. Los centros sanitarios alternativos se presentaron como favorecedores en la mejora de la salud de la población inmigrante y en su acceso.

  • Ling, Yiming
    et al.
    Shandong Univ, Sch Space Sci & Phys, Shandong Prov Key Lab Opt Astron & Solar Terr Env, Weihai, Peoples R China;Chinese Acad Sci, NSSC, State Key Lab Space Weather, Beijing, Peoples R China;Univ Sci & Technol China, Sch Earth & Space Sci, CAS Key Lab Geospace Environm, Hefei, Anhui, Peoples R China.
    Shi, Quanqi
    Shandong Univ, Sch Space Sci & Phys, Shandong Prov Key Lab Opt Astron & Solar Terr Env, Weihai, Peoples R China.
    Shen, Xiao-Chen
    Shandong Univ, Sch Space Sci & Phys, Shandong Prov Key Lab Opt Astron & Solar Terr Env, Weihai, Peoples R China.
    Tian, Anmin
    Shandong Univ, Sch Space Sci & Phys, Shandong Prov Key Lab Opt Astron & Solar Terr Env, Weihai, Peoples R China.
    Li, Wenya
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutet för rymdfysik, Uppsalaavdelningen. Chinese Acad Sci, NSSC, State Key Lab Space Weather, Beijing, Peoples R China.
    Tang, Binbin
    Chinese Acad Sci, NSSC, State Key Lab Space Weather, Beijing, Peoples R China.
    Degeling, A. W.
    Shandong Univ, Sch Space Sci & Phys, Shandong Prov Key Lab Opt Astron & Solar Terr Env, Weihai, Peoples R China.
    Hasegawa, Hiroshi
    Japan Aerosp Explorat Agcy JAXA, Inst Space & Astronaut Sci, Sagamihara, Kanagawa, Japan.
    Nowada, Motoharu
    Shandong Univ, Sch Space Sci & Phys, Shandong Prov Key Lab Opt Astron & Solar Terr Env, Weihai, Peoples R China.
    Zhang, Hui
    Univ Alaska, Geophys Inst, Fairbanks, AK 99701 USA.
    Rae, I. J.
    Univ Coll London, Mullard Space Sci Lab, Dorking, Surrey, England.
    Zong, Qiu-Gang
    Peking Univ, Sch Earth & Space Sci, Beijing, Peoples R China.
    Fu, Suiyan
    Peking Univ, Sch Earth & Space Sci, Beijing, Peoples R China.
    Fazakerley, A. N.
    Univ Coll London, Mullard Space Sci Lab, Dorking, Surrey, England.
    Pu, Zuyin
    Peking Univ, Sch Earth & Space Sci, Beijing, Peoples R China.
    Observations of Kelvin-Helmholtz Waves in the Earth's Magnetotail Near the Lunar Orbit2018Inngår i: Journal of Geophysical Research - Space Physics, ISSN 2169-9380, E-ISSN 2169-9402, Vol. 123, nr 5, s. 3836-3847Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Kelvin‐Helmholtz waves (KHWs), which have been widely observed at the magnetopause in the region near the Earth, play an essential role in the transport of solar wind plasma and energy into the magnetosphere under dominantly northward interplanetary magnetic field (IMF) conditions. In this study, we present simultaneous observations of KHWs under the northward IMF observed by both the Acceleration, Reconnection, Turbulence, and Electrodynamics of Moon's Interaction with the Sun (ARTEMIS) spacecraft in the Earth's magnetotail around the lunar orbit (at X ~ −50RE, Y ~ 30RE, dusk side) and the Geotail in the near‐Earth space (at X ~ −5RE, Y ~ −10RE, dawn side). The KHWs are quantitatively characterized by their dominant period, phase velocity, and wavelength, utilizing wavelet analysis and an approximation of their center‐of‐mass velocity. Our results suggest that the phase velocity and spatial scale of KHWs may increase as they propagate along the boundary layer toward the tail. Alternatively, the differences between the ARTEMIS and Geotail observations may indicate the possibility of dawn‐dusk asymmetry in the excited KHWs in this study. Our results strongly evidence the existence of the development of KHWs in terms of their wave frequency and scale size in the magnetotail and provide insight to the time evolution of KHWs along the magnetopause.

  • Cunningham, Anthony L.
    et al.
    Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia.
    Heineman, Thomas C.
    GSK, King Of Prussia, PA USA;Genocea Biosci, Cambridge, MA USA.
    Lal, Himal
    GSK, King Of Prussia, PA USA;Pfizer Inc, Collegeville, PA USA.
    Godeaux, Olivier
    GSK, Wavre, Belgium;Janssen Vaccines & Prevent, Leiden, Netherlands.
    Chlibek, Roman
    Univ Def, Fac Mil Hlth Sci, Hradec Kralove, Czech Republic.
    Hwang, Shinn-Jang
    Taipei Vet Gen Hosp, Dept Family Med, Taipei, Taiwan;Natl Yang Ming Univ, Sch Med, Taipei, Taiwan.
    McElhaney, Janet E.
    Hlth Sci North Res Inst, Sudbury, ON, Canada.
    Vesikari, Timo
    Univ Tampere, Vaccine Res Ctr, Tampere, Finland.
    Andrews, Charles
    Diagnost Res Grp, San Antonio, TX USA.
    Choi, Won Suk
    Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea.
    Esen, Meral
    Univ Clin Tuebingen, Inst Trop Med, Tubingen, Germany.
    Ikematsu, Hideyuki
    Japan Phys Assoc, Chiyoda Ku, Tokyo, Japan.
    Choma, Martina Kovac
    GSK, Rockville, MD USA.
    Pauksen, Karlis
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Infektionssjukdomar.
    Ravault, Stephanie
    GSK, Rixensart, Belgium.
    Salaun, Bruno
    GSK, Rixensart, Belgium.
    Schwarz, Tino F.
    Standort Juliusspital, Klinikum Wurzburg Mitte, Cent Lab & Vaccinat Ctr, Wurzburg, Germany.
    Smetana, Jan
    Univ Def, Fac Mil Hlth Sci, Hradec Kralove, Czech Republic.
    Vanden Abeele, Carline
    GSK, Wavre, Belgium.
    Van den Steen, Peter
    GSK, Wavre, Belgium.
    Vastiau, Ilse
    GSK, Wavre, Belgium.
    Weckx, Lily Yin
    Univ Fed Sao Paulo, Sao Paulo, Brazil.
    Levin, Myron J.
    Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO USA;Univ Colorado, Dept Med, Anschutz Med Campus, Aurora, CO USA.
    Immune Responses to a Recombinant Glycoprotein E Herpes Zoster Vaccine in Adults Aged 50 Years or Older2018Inngår i: Journal of Infectious Diseases, ISSN 0022-1899, E-ISSN 1537-6613, Vol. 217, nr 11, s. 1750-1760Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background. The herpes zoster subunit vaccine (HZ/su), consisting of varicella-zoster virus glycoprotein E (gE) and AS01(B) Adjuvant System, was highly efficacious in preventing herpes zoster in the ZOE-50 and ZOE-70 trials. We present immunogenicity results from those trials. Methods. Participants (ZOE-50: >= 50; ZOE-70: >= 70 years of age) received 2 doses of HZ/su or placebo, 2 months apart. Serum anti-gE antibodies and CD4 T cells expressing >= 2 of 4 activation markers assessed (CD4(2+)) after stimulation with gE-peptides were measured in subcohorts for humoral (n = 3293) and cell-mediated (n = 466) immunogenicity. Results. After vaccination, 97.8% of HZ/su and 2.0% of placebo recipients showed a humoral response. Geometric mean anti-gE antibody concentrations increased 39.1-fold and 8.3-fold over baseline in HZ/su recipients at 1 and 36 months post-dose 2, respectively. A gE-specific CD4(2+) T-cell response was shown in 93.3% of HZ/su and 0% of placebo recipients. Median CD42+ T-cell frequencies increased 24.6-fold (1 month) and 7.9-fold (36 months) over baseline in HZ/su recipients and remained >= 5.6-fold above baseline in all age groups at 36 months. The proportion of CD4 T cells expressing all 4 activation markers increased over time in all age groups. Conclusions. Most HZ/su recipients developed robust immune responses persisting for 3 years following vaccination.

  • Bjelland, Elisabeth Krefting
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin. Akershus Univ Hosp, Dept Obstet & Gynecol, POB 1000, N-1478 Lorenskog, Norway.
    Hofvind, S.
    Canc Registry Norway, Dept Mammog Screening, POB 5313, N-0304 Oslo, Norway.
    Byberg, Liisa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper.
    Eskild, A.
    Akershus Univ Hosp, Dept Obstet & Gynecol, POB 1000, N-1478 Lorenskog, Norway;Univ Oslo, Inst Clin Med, Campus Ahus,POB 1000, N-1478 Lorenskog, Norway.
    The relation of age at menarche with age at natural menopause: a population study of 336 788 women in Norway2018Inngår i: Human Reproduction, ISSN 0268-1161, E-ISSN 1460-2350, Vol. 33, nr 6, s. 1149-1157Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    STUDY QUESTION: Is age at menarche associated with age at menopause or with duration of the reproductive period (interval between menarche and menopause)? SUMMARY ANSWER: The association of age at menarche with age at menopause was weak and non-linear, and the duration of the reproductive period decreased by increasing age at menarche. WHAT IS KNOWN ALREADY: It remains uncertain whether age at menarche is associated with age at menopause. Some studies report that women with early menarche also have early menopause. Other studies report that women with early menarche have late menopause, or they report no association. The duration of the reproductive period may be an indicator of the cumulative endogenous exposure to estrogens and progestogens during life course and is associated with risk of breast cancer and endometrial cancer. STUDY DESIGN, SIZE, DURATION: A retrospective cohort study of 336 788 women, aged 48-71 years, in the BreastScreen Norway during the years 2006-2014 was performed. PARTICIPANTS/MATERIALS, SETTING, METHODS: Information about age at menarche and menopausal status was obtained by self-administered questionnaires. We used time to event approaches to estimate the associations. MAIN RESULTS AND THE ROLE OF CHANCE: Median age at menopause was 51 years in most menarche groups. Women with menarche at age 16 years or age >= 17 years had menopause 1 year later [median: 52 years, interquartile range (IQR): 49-54 years] than women with menarche at age 13 years (median: 51 years, IQR: 49-54 years, reference) (crude hazard ratio (HR) = 0.95; 95% CI: 0.93-0.97 and 0.95; 95% CI: 0.92-0.99, Pnon-linearity < 0.001). The reproductive period decreased with increasing age at menarche (Pnon-linearity < 0.001), and women with menarche at age <= 9 years had 9 years longer median reproductive period than women with menarche at age >= 17 years (median: 43 versus 34 years). Adjustment for year of birth did not change the HR estimates notably. LARGE SCALE DATA: Not applicable. LIMITATIONS, REASONS FOR CAUTION: Information about age at menarche and age at menopause was based on self-reports. Particularly for age at menarche, the long time interval between the event and data collection may have caused imprecise reporting. WIDER IMPLICATIONS OF THE FINDINGS: Our study suggests that age at menarche is a strong indicator for the duration of women's reproductive period. Our findings should encourage studies of the independent role of duration of the reproductive period on the risk of breast cancer and endometrial cancer, since these cancers have been associated with exposure to estrogens and progestogens. STUDY FUNDING/COMPETING INTEREST(S): The present study was funded by the Norwegian Cancer Society [Grant number 6863294-2015]. The authors declare no conflicts of interest.

  • Moerman, Paul
    Södertörns högskola, Institutionen för kultur och lärande, Estetiska lärprocesser. Södertörns högskola, Lärarutbildningen.
    Dance Art, Math, Education – An Eternal Triangle2018Inngår i: Proceedings of Bridges 2018 on Mathematics, Art, Music, Architecture, Education, Culture / [ed] Eve Torrence, Bruce Torrence, Carlo Sequin, Kristóf Fenyvesi, Phoenix, Arizona, 2018, s. 347-350Konferansepaper (Fagfellevurdert)
    Abstract [en]

    This paper discusses the nature of art activity, such as dance, in teaching and learning subject matter, such as math, querying what is left from the artistic when art is put to serve a cause, such as education. Does any partner, dance, math or education gain or give up more in the triangular affair?

  • Kullenberg, Christopher
    et al.
    University of Gothenburg.
    Rauden, Frauke
    University of Gothenburg.
    Björkvall, Anders
    Örebro University.
    Brounéus, Fredrik
    VA (Public & Science), Stockholm.
    Avellan-Hultman, Anders
    Järlehed, Johan
    University of Gothenburg.
    Van Meerbergen, Sara
    Stockholm University.
    Nord, Andreas
    University of Gothenburg.
    Lykke Nielsen, Helle
    University of Gothenburg / University of Southern Denmark, Odense, Denmark.
    Rosendal, Tove
    University of Gothenburg.
    Tomasson, Lotta
    VA (Public & Science), Stockholm.
    Westberg, Gustav
    Stockholm University.
    What are analog bulletin boards used for today?: Analysing media uses, intermediality and technology affordances in Swedish bulletin board messages using a citizen science approach2018Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 8, s. 1-21, artikkel-id e0202077Artikkel i tidsskrift (Fagfellevurdert)
  • Feitosa, Mary F.
    et al.
    Kraja, Aldi T.
    Chasman, Daniel I.
    Sung, Yun J.
    Winkler, Thomas W.
    Ntalla, Ioanna
    Guo, Xiuqing
    Franceschini, Nora
    Cheng, Ching-Yu
    Sim, Xueling
    Vojinovic, Dina
    Marten, Jonathan
    Musani, Solomon K.
    Li, Changwei
    Bentley, Amy R.
    Brown, Michael R.
    Schwander, Karen
    Richard, Melissa A.
    Noordam, Raymond
    Aschard, Hugues
    Bartz, Traci M.
    Bielak, Lawrence F.
    Dorajoo, Rajkumar
    Fisher, Virginia
    Hartwig, Fernando P.
    Horimoto, Andrea R. V. R.
    Lohman, Kurt K.
    Manning, Alisa K.
    Rankinen, Tuomo
    Smith, Albert V.
    Tajuddin, Salman M.
    Wojczynski, Mary K.
    Alver, Maris
    Boissel, Mathilde
    Cai, Qiuyin
    Campbell, Archie
    Chai, Jin Fang
    Chen, Xu
    Divers, Jasmin
    Gao, Chuan
    Goel, Anuj
    Hagemeijer, Yanick
    Harris, Sarah E.
    He, Meian
    Hsu, Fang-Chi
    Jackson, Anne U.
    Kahonen, Mika
    Kasturiratne, Anuradhani
    Komulainen, Pirjo
    Kuhnel, Brigitte
    Laguzzi, Federica
    Luan, Jian'an
    Matoba, Nana
    Nolte, Ilja M.
    Padmanabhan, Sandosh
    Riaz, Muhammad
    Rueedi, Rico
    Robino, Antonietta
    Said, M. Abdullah
    Scott, Robert A.
    Sofer, Tamar
    Stancakova, Alena
    Takeuchi, Fumihiko
    Tayo, Bamidele O.
    van der Most, Peter J.
    Varga, Tibor V.
    Vitart, Veronique
    Wang, Yajuan
    Ware, Erin B.
    Warren, Helen R.
    Weiss, Stefan
    Wen, Wanqing
    Yanek, Lisa R.
    Zhang, Weihua
    Zhao, Jing Hua
    Afaq, Saima
    Amin, Najaf
    Amini, Marzyeh
    Arking, Dan E.
    Aung, Tin
    Boerwinkle, Eric
    Borecki, Ingrid
    Broeckel, Ulrich
    Brown, Morris
    Brumat, Marco
    Burke, Gregory L.
    Canouil, Mickael
    Chakravarti, Aravinda
    Charumathi, Sabanayagam
    Chen, Yii-Der Ida
    Connell, John M.
    Correa, Adolfo
    Fuentes, Lisa de las
    de Mutsert, Renee
    de Silva, H. Janaka
    Deng, Xuan
    Ding, Jingzhong
    Duan, Qing
    Eaton, Charles B.
    Ehret, Georg
    Eppinga, Ruben N.
    Evangelou, Evangelos
    Fau, Jessica D.
    Felix, Stephan B.
    Forouhi, Nita G.
    Forrester, Terrence
    Franco, Oscar H.
    Friedlander, Yechiel
    Gandin, Ilaria
    Gao, He
    Ghanbari, Mohsen
    Gigante, Bruna
    Gu, C. Charles
    Gu, Dongfeng
    Hagenaars, Saskia P.
    Hallmans, Göran
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.
    Harris, Tamara B.
    He, Jiang
    Heikkinen, Sami
    Heng, Chew-Kiat
    Hirata, Makoto
    Howard, Barbara V.
    Ikram, M. Arfan
    John, Ulrich
    Katsuya, Tomohiro
    Khor, Chiea Chuen
    Kilpelainen, Tuomas O.
    Koh, Woon-Puay
    Krieger, Jose E.
    Kritchevsky, Stephen B.
    Kubo, Michiaki
    Kuusisto, Johanna
    Lakka, Timo A.
    Langefeld, Carl D.
    Langenberg, Claudia
    Launer, Lenore J.
    Lehne, Benjamin
    Lewis, Cora E.
    Li, Yize
    Lin, Shiow
    Liu, Jianjun
    Liu, Jingmin
    Loh, Marie
    Louie, Tin
    Magi, Reedik
    McKenzie, Colin A.
    Meitinger, Thomas
    Metspalu, Andres
    Milaneschi, Yuri
    Milani, Lili
    Mohlke, Karen L.
    Momozawa, Yukihide
    Nalls, Mike A.
    Nelson, Christopher P.
    Sotoodehnia, NelsonNona
    Norris, Jill M.
    O'Connell, Jeff R.
    Palmer, Nicholette D.
    Perls, Thomas
    Pedersen, Nancy L.
    Peters, Annette
    Peyser, Patricia A.
    Poulter, Neil
    Raffel, Leslie J.
    Raitakari, Olli T.
    Roll, Kathryn
    Rose, Lynda M.
    Rosendaal, Frits R.
    Rotter, Jerome I.
    Schmidt, Carsten O.
    Schreiner, Pamela J.
    Schupf, Nicole
    Scott, William R.
    Sever, Peter S.
    Shi, Yuan
    Sidney, Stephen
    Sims, Mario
    Sitlani, Colleen M.
    Smith, Jennifer A.
    Snieder, Harold
    Starr, John M.
    Strauch, Konstantin
    Stringham, Heather M.
    Tan, Nicholas Y. Q.
    Tang, Hua
    Taylor, Kent D.
    Teo, Yik Ying
    Tham, Yih Chung
    Turner, Stephen T.
    Uitterlinden, Andre G.
    Vollenweider, Peter
    Waldenberger, Melanie
    Wang, Lihua
    Wang, Ya Xing
    Bin Wei, Wen
    Williams, Christine
    Yao, Jie
    Yu, Caizheng
    Yuan, Jian-Min
    Zhao, Wei
    Zonderman, Alan B.
    Becker, Diane M.
    Boehnke, Michael
    Bowden, Donald W.
    Chambers, John C.
    Deary, Ian J.
    Esko, Tonu
    Farrall, Martin
    Franks, Paul W.
    Freedman, Barry I.
    Froguel, Philippe
    Gasparini, Paolo
    Gieger, Christian
    Jonas, Jost Bruno
    Kamatani, Yoichiro
    Kato, Norihiro
    Kooner, Jaspal S.
    Kutalik, Zoltan
    Laakso, Markku
    Laurie, Cathy C.
    Leander, Karin
    Lehtimaki, Terho
    Study, Lifelines Cohort
    Magnusson, Patrik K. E.
    Oldehinkel, Albertine J.
    Penninx, Brenda W. J. H.
    Poiasek, Ozren
    Porteous, David J.
    Rauramaa, Rainer
    Samani, Nilesh J.
    Scott, James
    Shu, Xiao-Ou
    van der Harst, Pim
    Wagenknecht, Lynne E.
    Wareham, Nicholas J.
    Watkins, Hugh
    Weir, David R.
    Wickremasinghe, Ananda R.
    Wu, Tangchun
    Zheng, Wei
    Bouchard, Claude
    Christensen, Kaare
    Evans, Michele K.
    Gudnason, Vilmundur
    Horta, Bernardo L.
    Kardia, Sharon L. R.
    Liu, Yongmei
    Pereira, Alexandre C.
    Psaty, Bruce M.
    Ridker, Paul M.
    van Dam, Rob M.
    Gauderman, W. James
    Zhu, Xiaofeng
    Mook-Kanamori, Dennis O.
    Fornage, Myriam
    Rotimi, Charles N.
    Cupples, L. Adrienne
    Kelly, Tanika N.
    Fox, Ervin R.
    Hayward, Caroline
    van Duijn, Cornelia M.
    Tai, E. Shyong
    Wong, Tien Yin
    Kooperberg, Charles
    Palmas, Walter
    Rice, Kenneth
    Morrison, Alanna C.
    Elliott, Paul
    Caulfield, Mark J.
    Munroe, Patricia B.
    Rao, Dabeeru C.
    Province, Michael A.
    Levy, Daniel
    Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries2018Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 6, artikkel-id e0198166Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in approximate to 131 K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P <1.0 x 10(-5)). In Stage 2, these SNVs were tested for independent external replication in individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10(-8)). For African ancestry samples, we detected 18 potentially novel BP loci (P< 5.0 x 10(-8)) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2 have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension.

  • Berntsson, Shala G.
    et al.
    Merrell, Ryan T.
    Amirian, E. Susan
    Armstrong, Georgina N.
    Lachance, Daniel
    Smits, Anja
    Zhou, Renke
    Jacobs, Daniel I.
    Wrensch, Margaret R.
    Olson, Sara H.
    Il'yasova, Dora
    Claus, Elizabeth B.
    Barnholtz-Sloan, Jill S.
    Schildkraut, Joellen
    Sadetzki, Siegal
    Johansen, Christoffer
    Houlston, Richard S.
    Jenkins, Robert B.
    Bernstein, Jonine L.
    Lai, Rose
    Shete, Sanjay
    Amos, Christopher I.
    Bondy, Melissa L.
    Melin, Beatrice S.
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study2018Inngår i: Journal of Neurology, ISSN 0340-5354, E-ISSN 1432-1459, Vol. 265, nr 6, s. 1432-1442Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls.

    Methods: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures.

    Results: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood.

    Conclusions: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor ***for developing glioma-related seizures or glioma.

  • Nygren, Thomas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Fakulteten för utbildningsvetenskaper, Institutionen för pedagogik, didaktik och utbildningsstudier.
    Digital källkritik i nyhetsflöden och undervisning2018Inngår i: Medie-och informationskunnighet (MIK) i den digitala tidsåldern: En demokratifråga -Kartläggning, analys, reflektioner / [ed] Ulla Carlsson, Nordicom, 2018, s. 63-67Konferansepaper (Annet vitenskapelig)
  • Disputas: 2018-09-21 13:00 Polhemsalen, 10134, Ångströmslaboratoriet, Uppsala
    Alghamdi, Azza
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Matematiska institutionen.
    Approximation of pluricomplex Green functions: A probabilistic approach2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    This PhD thesis focuses on probabilistic methods of approximation of pluricomplex Green functions and is based on four papers.

    The thesis begins with a general introduction to the use of pluricomplex Green functions in multidimensional complex analysis and a review of their main properties. This is followed by short description of the main results obtained in the enclosed papers.

    In Paper I, we study properties of the metric space of pluriregular sets, that is zero sets of continuous pluricomplex Green functions. The best understood non-trivial examples of such sets are composite Julia sets, obtained by iteration of finite families of polynomial mappings in several complex variables. We prove that the so-called chaos game is applicable in the case of such sets. We also visualize some composite Julia sets using escape time functions and Monte Carlo simulation.

    In Paper II, we extend results in Paper I to the case of infinite compact families of proper polynomials mappings. With composition as the semigroup operation, we generate families of infinite iterated function systems with compact attractors. We show that such attractors can be approximated probabilistically in a manner of the classic chaos game.

    In Paper III, we study numerical approximation and visualisation of pluricomplex Green functions based on the Monte-Carlo integration. Unlike alternative methods that rely on locating a sequence of carefully chosen finite sets of points satisfying some optimal conditions for approximation purposes, our approach is simpler and more direct by relying on generation of pseudorandom points. We examine numerically the errors of approximation for some simple geometric shapes for which the pluricomplex Green functions are known. If the pluricomplex Green functions are not known, the errors in Monte Carlo integration can be expressed with the aid of statistics in terms of confidence intervals.

    Finally, in Paper IV, we study how perturbations of an orthonomalization procedure influence the resulting approximate Bergman functions. To this end we consider the concept of near orthonormality of a finite set of vectors in an inner product space, understood as closeness of the Gram matrix of those vectors to the identity matrix. We provide estimates for the errors resulting from using nearly orthogonal bases instead of orthogonal ones. The motivation for this work comes from Paper III: when Gram matrices are calculated via Monte Carlo integration, the outcomes of standard orthogonalisation algorithms are nearly orthonormal bases.

  • Albrectsen, Benedicte Riber
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för fysiologisk botanik. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Umeå Plant Science Centre (UPSC).
    Siddique, Abu Bakar
    Decker, Vicki Huizu Guo
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Umeå Plant Science Centre (UPSC). Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för fysiologisk botanik.
    Unterseher, Martin
    Robinson, Kathryn M
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för fysiologisk botanik. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Umeå Plant Science Centre (UPSC).
    Both plant genotype and herbivory shape aspen endophyte communities2018Inngår i: Oecologia, ISSN 0029-8549, E-ISSN 1432-1939, Vol. 187, nr 2, s. 535-545Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Salicinoid phenolic glycosides are common defence substances in salicaceous trees and specialist leaf beetles use these compounds for their own defence against predators. Salicinoids vary qualitatively and qualitatively in aspen (Populus tremula) and this variation has a genetic basis. The foliar endophyte mycobiome is plentiful and we hypothesised that it is related to plant genotype, potentially mediated by salicinoid composition, and that interactions with the leaf beetle Chrysomela tremula may alter this relationship. We studied these three-way interactions in controlled greenhouse experiments. Endophytic fungi were isolated from sterilised leaf tissues with and without beetle damage, and from beetles. We confirmed that endophyte composition was influenced by host genotype. Beetle activity added generalist morphs to the mycobiome that overrode the initial host association. Yeast-like genera (Cryptococcus and Rhodotorula) were isolated only from beetle-damaged tissues and from beetles, whereas fast-growing filamentous fungi dominated beetle-free control plants. Competition experiments between filamentous fungi of plant origin and beetle-related yeasts suggested interaction of both stimulating and inhibiting modes of action amongst the fungi. As a result, we detected examples of amensalism, commensalism, parasitism and competition between the morphs tested, but we found no evidence of mutualism, and consequently no co-evolutionary relationship could be demonstrated, between yeasts carried by beetles, host genotype and associated filamentous morphs. Endophyte studies are method-dependent and high-throughput sequencing technology best define the fungal mycobiome, culturing however continues to be a cheap way to provide fundamental ecological insights and it is also required for experimental studies.

  • Dwibedi, Chinmay Kumar
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi. Umeå universitet, Medicinska fakulteten, Molekylär Infektionsmedicin, Sverige (MIMS). Division of CBRN Security and Defence, Swedish Defense Research Agency, Umeå, Sweden.
    Birdsell, Dawn
    Larkeryd, Adrian
    Myrtennas, Kerstin
    Ohrman, Caroline
    Nilsson, Elin
    Karlsson, Edvin
    Hochhalter, Christian
    Rivera, Andrew
    Maltinsky, Sara
    Bayer, Brittany
    Keim, Paul
    Scholz, Holger C.
    Tomaso, Herbert
    Wittwer, Matthias
    Beuret, Christian
    Schuerch, Nadia
    Pilo, Paola
    Hernandez Perez, Marta
    Rodriguez-Lazaro, David
    Escudero, Raquel
    Anda, Pedro
    Forsman, Mats
    Wagner, David M.
    Larsson, Par
    Johansson, Anders
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi. Umeå universitet, Medicinska fakulteten, Molekylär Infektionsmedicin, Sverige (MIMS).
    Long-range dispersal moved Francisella tularensis into Western Europe from the East2016Inngår i: Microbial Genomics, ISSN 2057-5858, Vol. 2, nr 12Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    For many infections transmitting to humans from reservoirs in nature, disease dispersal patterns over space and time are largely unknown. Here, a reversed genomics approach helped us understand disease dispersal and yielded insight into evolution and biological properties of Francisella tularensis, the bacterium causing tularemia. We whole-genome sequenced 67 strains and characterized by single-nucleotide polymorphism assays 138 strains, collected from individuals infected 1947-2012 across Western Europe. We used the data for phylogenetic, population genetic and geographical network analyses. All strains (n= 205) belonged to a monophyletic population of recent ancestry not found outside Western Europe. Most strains (n= 195) throughout the study area were assigned to a star-like phylogenetic pattern indicating that colonization of Western Europe occurred via clonal expansion. In the East of the study area, strains were more diverse, consistent with a founder population spreading from east to west. The relationship of genetic and geographic distance within the F. tularensis population was complex and indicated multiple long-distance dispersal events. Mutation rate estimates based on year of isolation indicated null rates; in outbreak hotspots only, there was a rate of 0.4 mutations/genome/year. Patterns of nucleotide substitution showed marked AT mutational bias suggestive of genetic drift. These results demonstrate that tularemia has moved from east to west in Europe and that F. tularensis has a biology characterized by long-range geographical dispersal events and mostly slow, but variable, replication rates. The results indicate that mutation-driven evolution, a resting survival phase, genetic drift and long-distance geographical dispersal events have interacted to generate genetic diversity within this species.

  • Bruening, Janina
    et al.
    Lasswitz, Lisa
    Banse, Pia
    Kahl, Sina
    Marinach, Carine
    Vondran, Florian W.
    Kaderali, Lars
    Silvie, Olivier
    Pietschmann, Thomas
    Meissner, Felix
    Gerold, Gisa
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi. Umeå universitet, Medicinska fakulteten, Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM). Insitute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.
    Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB2018Inngår i: PLoS Pathogens, ISSN 1553-7366, E-ISSN 1553-7374, Vol. 14, nr 7, artikkel-id e1007111Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Hepatitis C virus (HCV) and the malaria parasite Plasmodium use the membrane protein CD81 to invade human liver cells. Here we mapped 33 host protein interactions of CD81 in primary human liver and hepatoma cells using high-resolution quantitative proteomics. In the CD81 protein network, we identified five proteins which are HCV entry factors or facilitators including epidermal growth factor receptor (EGFR). Notably, we discovered calpain-5 (CAPN5) and the ubiquitin ligase Casitas B-lineage lymphoma proto-oncogene B (CBLB) to form a complex with CD81 and support HCV entry. CAPN5 and CBLB were required for a post-binding and pre-replication step in the HCV life cycle. Knockout of CAPN5 and CBLB reduced susceptibility to all tested HCV genotypes, but not to other enveloped viruses such as vesicular stomatitis virus and human coronavirus. Furthermore, Plasmodium sporozoites relied on a distinct set of CD81 interaction partners for liver cell entry. Our findings reveal a comprehensive CD81 network in human liver cells and show that HCV and Plasmodium highjack selective CD81 interactions, including CAPN5 and CBLB for HCV, to invade cells.

  • Nelson, Marie
    et al.
    Stockholms universitet, Humanistiska fakulteten, Institutionen för svenska och flerspråkighet, Svenska/Nordiska språk.
    Henricson, Sofie
    Åbo universitet, Nordiska språk.
    Hur språkliga råd motiveras och förklaras i finlandssvenska och sverigesvenska handledningssamtal2016Konferansepaper (Fagfellevurdert)
  • Rondung, Elisabet
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för psykologi.
    Ternström, Elin
    Uppsala University.
    Hildingsson, Ingegerd
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad. Uppsala University.
    Haines, Helen M
    The University of Melbourne, Victoria, Australia.
    Sundin, Örjan
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för psykologi.
    Ekdahl, Johanna
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för psykologi.
    Karlström, Annika
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Larsson, Birgitta
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Segeblad, Birgitta
    Uppsala University.
    Baylis, Rebecca
    Uppsala University.
    Rubertsson, Christine
    Uppsala University; Lund University.
    Comparing Internet-Based Cognitive Behavioral Therapy With Standard Care for Women With Fear of Birth: Randomized Controlled Trial.2018Inngår i: JMIR mental health, ISSN 2368-7959, Vol. 5, nr 3, artikkel-id e10420Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Although many pregnant women report fear related to the approaching birth, no consensus exists on how fear of birth should be handled in clinical care.

    OBJECTIVE: This randomized controlled trial aimed to compare the efficacy of a guided internet-based self-help program based on cognitive behavioral therapy (guided ICBT) with standard care on the levels of fear of birth in a sample of pregnant women reporting fear of birth.

    METHODS: This nonblinded, multicenter randomized controlled trial with a parallel design was conducted at three study centers (hospitals) in Sweden. Recruitment commenced at the ultrasound screening examination during gestational weeks 17-20. The therapist-guided ICBT intervention was inspired by the Unified protocol for transdiagnostic treatment of emotional disorders and consisted of 8 treatment modules and 1 module for postpartum follow-up. The aim was to help participants observe and understand their fear of birth and find new ways of coping with difficult thoughts and emotions. Standard care was offered in the three different study regions. The primary outcome was self-assessed levels of fear of birth, measured using the Fear of Birth Scale.

    RESULTS: We included 258 pregnant women reporting clinically significant levels of fear of birth (guided ICBT group, 127; standard care group, 131). Of the 127 women randomized to the guided ICBT group, 103 (81%) commenced treatment, 60 (47%) moved on to the second module, and only 13 (10%) finished ≥4 modules. The levels of fear of birth did not differ between the intervention groups postintervention. At 1-year postpartum follow-up, participants in the guided ICBT group exhibited significantly lower levels of fear of birth (U=3674.00, z=-1.97, P=.049, Cohen d=0.28, 95% CI -0.01 to 0.57). Using the linear mixed models analysis, an overall decrease in the levels of fear of birth over time was found (P≤ .001), along with a significant interaction between time and intervention, showing a larger reduction in fear of birth in the guided ICBT group over time (F1,192.538=4.96, P=.03).

    CONCLUSIONS: Fear of birth decreased over time in both intervention groups; while the decrease was slightly larger in the guided ICBT group, the main effect of time alone, regardless of treatment allocation, was most evident. Poor treatment adherence to guided ICBT implies low feasibility and acceptance of this treatment.

    TRIAL REGISTRATION: ClinicalTrials.gov NCT02306434; https://clinicaltrials.gov/ct2/show/NCT02306434 (Archived by WebCite at http://www.webcitation.org/70sj83qat).