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  • Martinsson, Lisa
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper.
    Lundström, Staffan
    Sundelöf, Johan
    Quality of end-of-life care in patients with dementia compared to patients with cancer: A population-based register study2018Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 7, artikkel-id e0201051Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction Globally, dementia is one of the leading causes of death. Given the growing elderly population in the world, the yearly number of deaths by dementia is expected to increase. Patients dying from dementia are reported to suffer from a burden of symptoms similar to that of patients with cancer, but receive less medication against symptoms, have a lower probability of palliative care planning and seldom have access to specialised palliative care. Studies investigating the quality of palliative care in dementia are scarce. The aim of this Swedish national study was to compare the quality of end-of-life care between patients with dementia and patients with cancer regardless of place of care. Methods Thirteen end-of-life care quality indicators collected by the Swedish Register of Palliative Care (SRPC) were compared between patients dying from dementia and patients dying from cancer. Data were collected from deaths occurring in nursing homes, hospitals, specialised and general palliative home care, and palliative in-patient units during a three-year period (during March 2012 to February 2015). Analyses were performed using a multivariable logistic regression model, adjusted for age and gender. A subgroup of patients with Alzheimer's disease was identified and compared to patients with other and unspecified types of dementia. Results A total of 4624 deaths from Alzheimer's disease, 11 804deaths from other dementia diagnoses and 51 609 deaths from cancer were included. For six of the 13 quality indicators examined (prescription of PRN drugs against nausea and anxiety, information and bereavement support offered to next of kin, pain assessment and specialised palliative care consultations), poorer outcomes were shown for the dementia group in comparison to the cancer group. Two outcomes (prevalence of pressure ulcers and fluid therapy during the last 24 hours in life) showed better outcomes for the dementia group. The outcomes for the 13 quality indicators were similar for patients with Alzheimer's disease compared to patients with other and unspecified types of dementia. Conclusions The findings in this study indicates that patients dying from Alzheimer's disease and other types of dementia receive a poorer quality of end-of-life care concerning several important end-of-life care areas when compared to patients dying from cancer. Guidelines for end-of-life care in Sweden cannot explain or justify these differences. Further studies are needed to find possible ways to improve end-of-life care in the large and growing group of patients dying from dementia.

  • Rudberg, Gunnar
    Nordiska museet.
    Ett seglifvat grafbruk1909Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1909, s. 109-112Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Wistrand, Per Gustaf
    Nordiska museet.
    Attartal hos Sveriges allmoge1909Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1909, s. 101-108Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Disputas: 2018-09-13 13:00 Forum Humanum, Jönköping
    Wang, Lan
    Högskolan i Jönköping, Hälsohögskolan, HHJ. ADULT.
    A health coaching self-management programme for patients with Chronic Obstructive Pulmonary Disease: An explorative and interventional study2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Background: Chronic Obstructive Pulmonary Disease (COPD) is a primary cause of chronic morbidity and mortality and contributes to an increased economic and social burden on patients and families. Self-management education as one non-pharmacological treatment approach is highlighted in guidelines. Although self-management programmes have shown positive effects for COPD, lack of disease-specific self-management skills, high dropout rates, and poor attendance of participants are problems which should be taken under consideration. One way to cope with the problems is to use amore motivational approach which focuses on patients’ health decisions in cooperation with healthcare practitioners, combined with systematic and structured health coaching. However, there is a lack of such studies, which are needed to explore the effects of self-management on patients with COPD by health coaching, not least in China.

    Aims: The overall aim of this thesis was to explore sociodemographic and clinical factors influencing self-management and to test and evaluate a health coaching self-management programme for patients with COPD in China.

    Methods: The study’s design was explorative, prospective, and longitudinal, with both quantitative and qualitative approaches. Specifically, a quantitative method with a cross-sectional approach was used to explore the self-management status of patients with COPD and examine the associations with socio-demographic and clinical variables (I). Furthermore, a prospective randomized controlled trial was conducted to study the longitudinal effects of the health coaching self-management programme using a repeated-measures analysis of variance model of patients with COPD (II & III). A qualitative study implementing inductive content analysis was used to describe and explore participants’ experiences of the health coaching self-management programme of patients with COPD (IV).

    Results: High physical activity, high salary, and low age affected the self-management of patients with COPD most positively (I). The health coaching programme improved lung function, physical activity, quality of life, and self-management skills, as well as psychological status in both the short and long term (II & III). Participants expressed their experiences of the health coaching self-management programme as making them more aware of the importance of knowledge of the disease and their own responsibilities, taking action to maintain a healthy lifestyle, feeling supported by the programme, and being hindered by individual and programme limitations (IV).

    Conclusions: This thesis contributes to knowledge about the self-management skills of patients with COPD, which is low in China. A health coaching self-management programme with iterative interactions between patients and healthcare professionals represented a valuable and effective intervention designed to improve health-related outcomes. Moreover, low literacy, poor physical condition, and family and economic burdens should be taken into account in the development of future self-management programmes in China.

  • Hallström, Gustaf
    Nordiska museet.
    Båtar och båtbyggnad i ryska lappmarken1909Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1909, s. 85-100Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Tedre, Matti
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Competing Claims to Computing as a Discipline (Invited talk)2015Inngår i: 15th Congress of Logic, Methodology and Philosophy of Science, University of Helsinki , 2015Konferansepaper (Fagfellevurdert)
  • Stirna, Janis
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Institutionen för data- och systemvetenskap.
    Capability Driven Development of Context-aware Enterprise Applications – Challenges, Approach and Experiences2015Inngår i: 5th Enterprise Engineering Working Conference, CIAO! Network , 2015Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Enterprises are facing the need to adapt their businesses according to various situations in which their applications need to be used. To answer this challenge an EU FP7 project “Capability as a Service in digital enterprises” (CaaS) has been initiated. The aim of CaaS is to support the capture and analysis of changing business context in the design of information systems (IS) using the capability notion. Capability is seen as the ability and capacity that enables an enterprise to achieve a business goal in a certain context. The key rationale behind a capability driven approach is to capture the dependence of organizational and IS designs on application context and to provide explicit support for run-time adjustments according to changes in the application situation. The CaaS project is developing a methodology and a tool environment for capability driven development. We envision to further advance the service oriented paradigm and to develop context aware business capabilities by using Enterprise Modelling techniques as a starting point of the development process, capability design patterns for reuse of best practices, as well as composition of required capabilities and algorithms for run-time adjustment. This talk will address the main principles of the capability driven development methodology, as well as present the current experiences of capability design in three use case companies of the CaaS project – SIV AG (Germany) for business process outsourcing, Fresh T Limited (UK) for compliance management, and Everis (Spain) for capability management in e-government platforms.

  • Flentzberg, Ant
    Nordiska museet.
    Offerkällor och trefaldighetskällor1909Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1909, s. 65-84Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Flexible work arrangements: The Nordic Gender Effect at Work2018Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    Promoting gender equality at work is not only a matter of rights; it is the smart thing to do from the perspective of inclusive growth. The Nordic region is a case in point, as it has come to represent the 11th largest economy in the world, not despite policy commitments to gender equality and social justice, but because of it. The Nordic countries have robust economies and good living conditions, where both women and men have high labour force participation rates. However, the gender pay gap is persistent and occupational segregation continues to hinder gender equality.

    The Nordic Gender Effect at Work briefs share the collective Nordic experience in investing in gender equality including parental leave, childcare, flexible work arrangements, leadership and equal opportunities at work, and seek to make further progress through cooperation.

  • Leadership and equal opportunities at work: The Nordic Gender Effect at Work2018Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    Promoting gender equality at work is not only a matter of rights; it is the smart thing to do from the perspective of inclusive growth. The Nordic region is a case in point, as it has come to represent the 11th largest economy in the world, not despite policy commitments to gender equality and social justice, but because of it. The Nordic countries have robust economies and good living conditions, where both women and men have high labour force participation rates. However, the gender pay gap is persistent and occupational segregation continues to hinder gender equality.

    The Nordic Gender Effect at Work briefs share the collective Nordic experience in investing in gender equality including parental leave, childcare, flexible work arrangements, leadership and equal opportunities at work, and seek to make further progress through cooperation.

  • Karlsson, Lis Bodil
    et al.
    Institutionen för socialt arbete, Stockholms Universitet.
    Gunnarsson, Evy
    Institutionen för socialt arbete, Stockholms Universitet.
    Hemtjänstpersonals förhållningssätt till äldre personer med alkoholproblem2018Inngår i: Arbetsmarknad & Arbetsliv, ISSN 1400-9692, Vol. 24, nr 1-2, s. 47-61-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [sv]

    Denna artikel fokuserar på hur hemtjänstpersonal förhåller sig till utmaningar och dilemman med omsorgstagare med alkoholproblem. Analysen visar hur personalen fokuserar på att spela en roll som omsorgsgivare och förmågan att ”spela teater” som några av förutsättningarna för arbetet. Goffmans dramaturgiska begreppsapparat respektive Hochschilds teorier om emotionellt lönearbete används för att tolka resultaten.

  • Romdahl, Axel
    Nordiska museet.
    Anteckningar till tallrikens historia1909Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1909, s. 60-63Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Hård af Segerstad, Kerstin
    Nordiska museet.
    Julebispen och Saint Coisne1909Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1909, s. 54-59Kapittel i bok, del av antologi (Annet vitenskapelig)
  • NN, nn
    Nordiska museet.
    Kakelfynd från Stockholm1909Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1909, s. 49-54Kapittel i bok, del av antologi (Annet vitenskapelig)
  • The Nordic Gender Effect at Work: Nordic experiences on parental leave, childcare, flexible work arrangements, leadership and equal opportunities at work2018Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    Promoting gender equality at work is not only a matter of rights; it is the smart thing to do from the perspective of inclusive growth. The Nordic region is a case in point, as it has come to represent the 11th largest economy in the world, not despite policy commitments to gender equality and social justice, but because of it. The Nordic countries have robust economies and good living conditions, where both women and men have high labour force participation rates. However, the gender pay gap is persistent and occupational segregation continues to hinder gender equality.

    The Nordic Gender Effect at Work briefs share the collective Nordic experience in investing in gender equality including parental leave, childcare, flexible work arrangements, leadership and equal opportunities at work, and seek to make further progress through cooperation.

  • Ljungdahl, D
    Nordiska museet.
    Fiskebod vid Backa Väddö1909Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1909, s. 46-49Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Van Hemelrijck, Mieke
    et al.
    Ulmer, Hanno
    Nagel, Gabriele
    Peter, Raphael Simon
    Fritz, Josef
    Myte, Robin
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper.
    van Guelpen, Bethany
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper.
    Föger, Bernhard
    Concin, Hans
    Häggström, Christel
    Umeå universitet, Medicinska fakulteten, Enheten för biobanksforskning. Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning. Uppsala University, Department of Surgical Sciences, Uppsala, Sweden.
    Stattin, Pär
    Uppsala University, Department of Surgical Sciences, Uppsala, Sweden.
    Stocks, Tanja
    Longitudinal study of body mass index, dyslipidemia, hyperglycemia, and hypertension in 60,000 men and women in Sweden and Austria2018Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 6, artikkel-id e0197830Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Obesity is suggested to underlie development of other metabolic aberrations, but longitudinal relationships between metabolic factors at various ages has not been studied in detail. Methods: Data from 27,379 men and 32,275 women with in total 122,940 health examinations in the Västerbotten Intervention Project, Sweden and the Vorarlberg Health Monitoring and Prevention Programme, Austria were used to investigate body mass index (BMI), mid-blood pressure, and fasting levels of glucose, triglycerides, and total cholesterol at baseline in relation to 10-year changes of these factors and weight. We included paired examinations performed 10 +/- 2 years apart and used them for longitudinal analysis with linear regression of changes between the ages 30 and 40, 40 and 50, or 50 and 60 years. Results: Higher levels of BMI were associated with increases in glucose and mid-blood pressure as well as triglycerides levels, and, to a lesser extent, decreases in cholesterol levels. For instance, per 5 kg/m(2) higher BMI at age 40, glucose at age 50 increased by 0.24 mmol/l (95%Cl:0.22-0.26) and mid-blood pressure increased by 1.54 mm Hg (95%Cl: 1.35-1.74). The strongest association observed was between BMI at age 30 and mid-blood pressure, which was 2.12 mm Hg (95% CI: 1.79-2.45) increase over ten years per 5 kg/m(2) higher BMI level. This association was observed at an age when blood pressure levels on average remained stable. Other associations than those with BMI at baseline were much weaker. However, triglyceride levels were associated with future glucose changes among individuals with elevated BMI, particularly in the two older age groups. Conclusion: BMI was most indicative of long-term changes in metabolic factors, and the strongest impact was observed for increases in blood pressure between 30 and 40 years of age. Our study supports that lifestyle interventions preventing metabolic aberrations should focus on avoiding weight increases.

  • Strandlund, Elin
    et al.
    Psykologiska institutionen, Stockholms universitet.
    Bernhard-Oettel, Claudia
    Psykologiska institutionen, Stockholms universitet.
    Låstad, Lena
    Psykologiska institutionen, Stockholms universitet och Psykologiska institutionen, Göteborgs universitet.
    Otrygghet – oro – ohälsa? En studie bland handelsanställda2018Inngår i: Arbetsmarknad & Arbetsliv, ISSN 1400-9692, Vol. 24, nr 1-2, s. 27-46Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [sv]

    Inom detaljhandeln har alternativa anställningar såsom behovs- och deltidsarbeten blivit allt vanligare. Dessa anställningar kan kombineras på flera sätt och är ofta svåra att särskilja. Föreliggande studie undersöker olika anställningssituationer inom handeln, vad som karakteriserar individer som innehar dessa anställningar samt om deras upplevelser av ekonomisk oro, anställningsotrygghet och självskattad hälsa skiljer sig åt. Data samlades in via en webbenkät. Med klusteranalys identifierades sex åtskilda anställningssituationer bland urvalet (N=138). Analyser av mellangruppsskillnader indikerade att de anställningssituationer som var förknippade med mest utsatthet var nollkontraktsanställda samt tillsvidareanställda på deltid, i jämförelse med tillsvidare- och timanställda studenter som verkade vara minst utsatta.

  • Upmark, Gustaf
    Nordiska museet.
    En gesällbok från 1700-talet1909Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1909, s. 37-45Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Ambrosiani, Sune
    Nordiska museet.
    Lår från Mysslinge1909Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1909, s. 15-36Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Cederblom, Gerda
    Nordiska museet.
    Några af våra äldsta spånadsredskap1909Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1909, s. 1-14Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Arne, T J
    Nordiska museet.
    Järnringar i berget1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 247-248Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Sundberg, Isak
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Psykiatri, Akademiska sjukhuset.
    Lannergård, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Infektionsmedicin.
    Ramklint, Mia
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Psykiatri, Akademiska sjukhuset.
    Cunningham, Janet L
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Psykiatri, Akademiska sjukhuset.
    Direct-acting antiviral treatment in real world patients with hepatitis C not associated with psychiatric side effects: a prospective observational study2018Inngår i: BMC Psychiatry, ISSN 1471-244X, E-ISSN 1471-244X, Vol. 18, artikkel-id 157Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Treatment of Hepatitis C virus (HCV) infection has evolved from interferon (IFN)-based treatments to direct-acting antivirals (DAAs). Patients with HCV have an elevated psychiatric morbidity (including substance abuse) and patients with such comorbidity have often been excluded from treatment with IFN. To date, little is known about psychiatric adverse effects of DAA-based regimens. We therefore aimed to study the psychiatric side effects of new IFN-free treatment for HCV (including depressive symptoms and sleep) in real world patients also including those with a history of psychiatric diagnosis, substance abuse or drug dependence. Methods: Consecutive patients were monitored during treatment with three of the latest DAA agents (sofosbuvir, simeprevir and daclatasvir). Repeated expert psychiatric assessments from baseline to 12 weeks post-treatment were performed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) clinical version and the self-report versions of the Montgomery Asberg Depression Rating Scale (MADRS-S) and the Pittsburgh Sleep Quality Index (PSQI). Friedman's test was performed to calculate differences in the MADRS-S and PSQI over time. In a post-hoc analysis Wilcoxon's test was used to compare baseline depressive symptoms with those at post-treatment. Spearman's rank correlation test was conducted in another post-hoc analysis to evaluate the correlation between symptoms of depression and HCV viral load at baseline. Results: At baseline, 15/17 patients (88%) had a history of any psychiatric diagnosis; 11 (65%) had a history of substance abuse or dependence; and 11 (65%) had previously been treated with IFN and six of those had experienced psychiatric side effects. There was no correlation between depressive symptoms and HCV viral load at baseline. Symptoms of depression did not increase during DAA treatment and were lower 12 weeks post-treatment compared with baseline: MADRS-S 10.7 vs. 8.3 (p = 0.01). This observation held when excluding patients taking antidepressant medication. Sleep quality did not significantly change during treatment. Adherence to treatment was estimated to 95% and sustained virological response was 88%. Conclusions: Despite high psychiatric morbidity, including previous substance abuse, patients successfully completed DAA treatment without increasing depressive symptoms or sleep disturbance. Symptoms of depression were significantly reduced 12 weeks after DAA treatment.

  • Eriksson, Daniel
    et al.
    Karolinska Inst, Dept Med Solna, Ctr Mol Med, Stockholm, Sweden;Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, Stockholm, Sweden.
    Bianchi, Matteo
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Landegren, Nils
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Autoimmunitet. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Dept Med Solna, Ctr Mol Med, Stockholm, Sweden.
    Dalin, Frida
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Dermatologi och venereologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Dept Med Solna, Ctr Mol Med, Stockholm, Sweden.
    Skov, Jakob
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Hultin-Rosenberg, Lina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Mathioudaki, Argyri
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Nordin, Jessika
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Hallgren, Asa
    Karolinska Inst, Dept Med Solna, Ctr Mol Med, Stockholm, Sweden.
    Andersson, Goran
    Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden.
    Tandre, Karolina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Dahlqvist, Solbritt Rantapaa
    Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
    Soderkvist, Peter
    Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden.
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Hulting, Anna-Lena
    Wahlberg, Jeanette
    Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden;Linkoping Univ, Dept Endocrinol, Linkoping, Sweden;Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.
    Dahlqvist, Per
    Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
    Ekwall, Olov
    Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
    Meadows, Jennifer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Lindblad-Toh, Kerstin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Broad Inst MIT & Harvard, Cambridge, MA USA.
    Bensing, Sophie
    Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, Stockholm, Sweden;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Pielberg, Gerli
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Kampe, Olle
    Karolinska Inst, Dept Med Solna, Ctr Mol Med, Stockholm, Sweden;Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, Stockholm, Sweden;KG Jebsen Ctr Autoimmune Dis, Bergen, Norway.
    Common genetic variation in the autoimmune regulator (AIRE) locus is associated with autoimmune Addison's disease in Sweden2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 8395Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Autoimmune Addison's disease (AAD) is the predominating cause of primary adrenal failure. Despite its high heritability, the rarity of disease has long made candidate-gene studies the only feasible methodology for genetic studies. Here we conducted a comprehensive reinvestigation of suggested AAD risk loci and more than 1800 candidate genes with associated regulatory elements in 479 patients with AAD and 2394 controls. Our analysis enabled us to replicate many risk variants, but several other previously suggested risk variants failed confirmation. By exploring the full set of 1800 candidate genes, we further identified common variation in the autoimmune regulator (AIRE) as a novel risk locus associated to sporadic AAD in our study. Our findings not only confirm that multiple loci are associated with disease risk, but also show to what extent the multiple risk loci jointly associate to AAD. In total, risk loci discovered to date only explain about 7% of variance in liability to AAD in our study population.

  • Olsdotter, Grop Anna
    Nordiska museet.
    Brud- och brudpigeutstyrslar i Ore socken, Dalarna på 1850-70-talen1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 242-247Kapittel i bok, del av antologi (Annet vitenskapelig)
  • NN, nn
    Nordiska museet.
    Lilit i Norrland1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 241-Kapittel i bok, del av antologi (Annet (populærvitenskap, debatt, mm))
  • Qvistgaard, A
    Nordiska museet.
    Om tolfhålakringlor och andra julbröd1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 235-241Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Bejerot, Eva
    et al.
    Handelshögskolan vid Örebro Universitet.
    Hasselbladh, Hans
    Handelshögskolan vid Örebro Universitet.
    Forsberg, Tina
    Sociologiska institutionen, Stockholms universitet.
    Parding, Karolina
    Luleå tekniska universitet.
    Sehlstedt, Therese
    Luleå tekniska universitet.
    Westerlund, Joakim
    Psykologiska institutionen, Stockholms universitet.
    Förberedd för läraryrket? Lärare under 40 år av reformer2018Inngår i: Arbetsmarknad & Arbetsliv, ISSN 1400-9692, Vol. 24, nr 1-2, s. 7-26Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [sv]

    Studien belyser hur gymnasielärare retrospektivt uppfattar att de förberetts för sitt yrke under lärarutbildningen. Enkätsvar från 1554 gymnasielärare kategoriserades efter den tidsperiod då de examinerades. Frågan om hur väl förberedda de nyexaminerade lärarna var för sitt yrke kopplas till de nationella reformer som styrde lärarutbildningen under den period som läraren studerade. Medan utbildningen i praktisk yrkeskunskap uppfattas ha försämrats över tid, har andra områden förbättrats. Lärosäte hade inte något samband med respondenternas svarsmönster. Slutsatsen är att utbildningsreformerna har samband med förändringar i utbildningens måluppfyllelse, att förbereda lärarstudenter för sitt yrke, samt att utbildningens anpassning till yrkets krav försämrats över tid.

  • Haglund, Lotta
    et al.
    Gymnastik- och idrottshögskolan, GIH.
    Roos, Annikki
    Karolinska Institutet University Library.
    Wallgren-Björk, Petra
    Danderyd University Hospital.
    Health science libraries in Sweden: new directions, expanding roles.2018Inngår i: Health Information and Libraries Journal, ISSN 1471-1834, E-ISSN 1471-1842Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Librarians in Sweden are facing huge challenges in meeting the demands of their organisations and users. This article looks at four key areas: coping with open science/open access initiatives; increasing demands from researchers for support doing systematic reviews; understanding user experiences in Swedish health science libraries; and the consequences of expanding roles for recruitment and continuing professional development. With regard to changing roles, there is an increasing shift from the generalist towards the expert role. The authors raise the issue as to how to prepare those new to the profession to the changing environment of health science libraries.

  • Rudberg, Gunnar
    Nordiska museet.
    Psalm - visa1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 230-235Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Czymzik, Markus
    et al.
    GFZ German Res Ctr Geosci, Sect Climate Dynam & Landscape Evolut 5 2, D-14473 Potsdam, Germany;Leibniz Inst Balt Sea Res Warnemunde IOW, Marine Geol, D-18119 Rostock, Germany.
    Muscheler, Raimund
    Lund Univ, Quaternary Sci, Dept Geol, S-22362 Lund, Sweden.
    Adolphi, Florian
    Lund Univ, Quaternary Sci, Dept Geol, S-22362 Lund, Sweden;Univ Bern, Inst Phys, Climate & Environm Phys, CH-3012 Bern, Switzerland.
    Mekhaldi, Florian
    Lund Univ, Quaternary Sci, Dept Geol, S-22362 Lund, Sweden.
    Draeger, Nadine
    GFZ German Res Ctr Geosci, Sect Climate Dynam & Landscape Evolut 5 2, D-14473 Potsdam, Germany.
    Ott, Florian
    GFZ German Res Ctr Geosci, Sect Climate Dynam & Landscape Evolut 5 2, D-14473 Potsdam, Germany;Max Planck Inst Sci Human Hist, D-07743 Jena, Germany.
    Slowinski, Michal
    Polish Acad Sci, Inst Geog & Spatial Org, PL-00818 Warsaw, Poland.
    Blaszkiewicz, Miroslaw
    Polish Acad Sci, Inst Geog & Spatial Org, PL-00818 Warsaw, Poland;Polish Acad Sci, Inst Geog & Spatial Org, PL-87100 Torun, Poland.
    Aldahan, Ala
    United Arab Emirates Univ, Dept Geol, Al Ain 15551, U Arab Emirates.
    Possnert, Göran
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, Tandemlaboratoriet.
    Brauer, Achim
    GFZ German Res Ctr Geosci, Sect Climate Dynam & Landscape Evolut 5 2, D-14473 Potsdam, Germany.
    Synchronizing 10Be in two varved lake sediment records to IntCal13 14C during three grand solar minima2018Inngår i: Climate of the Past, ISSN 1814-9324, E-ISSN 1814-9332, Vol. 14, nr 5, s. 687-696Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Timescale uncertainties between paleoclimate reconstructions often inhibit studying the exact timing, spatial expression and driving mechanisms of climate variations. Detecting and aligning the globally common cosmogenic radionuclide production signal via a curve fitting method provides a tool for the quasi-continuous synchronization of paleoclimate archives. In this study, we apply this approach to synchronize Be-10 records from varved sediments of Tiefer See and Lake Czechowskie covering the Maunder, Homeric and 5500 a BP grand solar minima with C-14 production rates inferred from the IntCal13 calibration curve. Our analyses indicate best fits with C-14 production rates when the Be-10 records from Tiefer See were shifted for 8 (-12/+4) (Maunder Minimum), 31 (-16/+12) (Homeric Minimum) and 86 (-22/+18) years (5500 a BP grand solar minimum) towards the past. The best fit between the Lake Czechowskie Be-10 record for the 5500 a BP grand solar minimum and C-14 production was obtained when the Be-10 time series was shifted 29 (-8/+7) years towards present. No significant fits were detected between the Lake Czechowskie Be-10 records for the Maunder and Homeric minima and C-14 production, likely due to intensified in-lake sediment resuspension since about 2800 a BP, transporting "old" Be-10 to the coring location. Our results provide a proof of concept for facilitating Be-10 in varved lake sediments as a novel synchronization tool required for investigating leads and lags of proxy responses to climate variability. However, they also point to some limitations of Be-10 in these archives, mainly connected to in-lake sediment resuspension processes.

  • Hammarstedt, N E
    Nordiska museet.
    Brorskål och blodsförbund1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 220-229Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Clement, Alice
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi. Flinders Univ S Australia, Coll Sci & Engn, Adelaide, SA, Australia;Museum Victoria, Dept Sci, Melbourne, Vic, Australia.
    King, Benedict
    Flinders Univ S Australia, Coll Sci & Engn, Adelaide, SA, Australia;Nat Biodivers Ctr, Leiden, Netherlands.
    Giles, Sam
    Univ Oxford, Dept Earth Sci, Oxford, England.
    Choo, Brian
    Flinders Univ S Australia, Coll Sci & Engn, Adelaide, SA, Australia.
    Ahlberg, Per
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
    Young, Gavin C.
    Australian Natl Univ, Res Sch Phys & Engn, Dept Appl Math, Canberra, ACT, Australia;Australian Museum, Res Inst, Sydney, NSW, Australia.
    Long, John A.
    Flinders Univ S Australia, Coll Sci & Engn, Adelaide, SA, Australia;Museum Victoria, Dept Sci, Melbourne, Vic, Australia.
    Neurocranial anatomy of an enigmatic Early Devonian fish sheds light on early osteichthyan evolution2018Inngår i: eLIFE, E-ISSN 2050-084X, Vol. 7, artikkel-id e34349Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The skull of 'Ligulalepis' from the Early Devonian of Australia (AM-F101607) has significantly expanded our knowledge of early osteichthyan anatomy, but its phylogenetic position has remained uncertain. We herein describe a second skull of 'Ligulalepis' and present micro-CT data on both specimens to reveal novel anatomical features, including cranial endocasts. Several features previously considered to link 'Ligulalepis' with actinopterygians are now considered generalized osteichthyan characters or of uncertain polarity. The presence of a lateral cranial canal is shown to be variable in its development between specimens. Other notable new features include the presence of a pineal foramen, the some detail of skull roof sutures, the shape of the nasal capsules, a placoderm-like hypophysial vein, and a chondrichthyan-like labyrinth system. New phylogenetic analyses place 'Ligulalepis' as a stem osteichthyan, specifically as the sister taxon to 'psarolepids' plus crown osteichthyans. The precise position of 'psarolepids' differs between parsimony and Bayesian analyses.

  • Reimer, Ludvig
    Nordiska museet.
    Seder och bruk i Albo härad i början av 1800-talet1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 208-219Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Hallström, Gustaf
    Nordiska museet.
    Några grafvar i Jukkasjärvi kyrka II1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 202-207Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Leijonhufvud, Sigrid
    Nordiska museet.
    Några grafvar i Jukkasjärvi kyrka I1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 193-202Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Phuyal, Dibya
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Jain, Sagar Motilal
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi. Swansea Univ, Coll Engn, SPECIFIC, Bay Campus,Fabian Way, Swansea SA1 8EN, W Glam, Wales.
    Philippe, Bertrand
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Johansson, Malin B
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi.
    Pazoki, Meysam
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Strukturkemi.
    Kullgren, Jolla
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Strukturkemi.
    Kvashnina, Kristina O.
    ESRF, Rossendorf Beamline, CS40220, F-38043 Grenoble 9, France;HZDR, Inst Resource Ecol, POB 510119, D-01314 Dresden, Germany.
    Klintenberg, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori.
    Johansson, Erik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi.
    Butorin, Sergei
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Karis, Olof
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Rensmo, Håkan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    The electronic structure and band interface of cesium bismuth iodide on a titania heterostructure using hard X-ray spectroscopy2018Inngår i: Journal of Materials Chemistry A, ISSN 2050-7488, Vol. 6, nr 20, s. 9498-9505Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Bismuth halide compounds as a non-toxic alternative are increasingly investigated because of their potential in optoelectronic devices and their rich structural chemistry. Hard X-ray spectroscopy was applied to the ternary bismuth halide Cs3Bi2I9 and its related precursors BiI3 and CsI to understand its electronic structure at an atomic level. We specifically investigated the core levels and valence band using X-ray photoemission spectroscopy (PES), high-resolution X-ray absorption (HERFD-XAS), and resonant inelastic X-ray scattering (RIXS) to get insight into the chemistry and the band edge properties of the two bismuth compounds. Using these element specific X-ray techniques, our experimental electronic structures show that the primary differences between the two bismuth samples are the position of the iodine states in the valence and conduction bands and the degree of hybridization with bismuth lone pair (6s(2)) states. The crystal structure of the two layered quasi-perovskite compounds plays a minor role in modifying the overall electronic structure, with variations in bismuth lone pair states and iodine band edge states. Density Functional Theory (DFT) calculations are used to compare with experimental data. The results demonstrate the effectiveness of hard X-ray spectroscopies to identify element specific bulk electronic structures and their use in optoelectronic devices.

  • Hammarstedt, N E
    Nordiska museet.
    En lapsk båt1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 149-155Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Bergman, Ann
    et al.
    Karlstads universitet, Fakulteten för humaniora och samhällsvetenskap (from 2013), Handelshögskolan (from 2013).
    Gillberg, Gunnar
    Institutionen för sociologi och arbetsvetenskap, Göteborgs universitet.
    Ivarsson, Lars
    Karlstads universitet, Fakulteten för humaniora och samhällsvetenskap (from 2013), Handelshögskolan (from 2013).
    Profession, anställningsformer, frivilligarbete och religion2018Inngår i: Arbetsmarknad & Arbetsliv, ISSN 1400-9692, Vol. 24, nr 1-2, s. 4-6Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [sv]

    Artiklarna i detta nummer av Arbetsmarknad & Arbetsliv behandlar olika områden. Den första handlar om hur gymnasielärare upplever att de förberetts för sitt yrke under lärarutbildningen. Den andra rör hemtjänstens förhållningssätt till äldre personer med alkoholproblem. Den tredje artikeln handlar om anställda i handeln, en bransch som kännetecknas av olika typer av anställningsformer. Nästa artikel belyser samverkan mellan räddningstjänsten och frivilliga insatser vid branden i Västmanland för några år sedan. Därefter följer en artikel om begränsningen av kvinnors rätt att manifestera sin religion i arbetslivet. Numret avslutas med tre recensioner. Eskil Wadensjö recenserar Tora Nords doktorsavhandling Arbete som rättighet eller skyldighet. Föreställningar om arbetsmarknadsfrånvaro i välfärdsstaten; Peter Håkansson recenserar Jack Lainpeltos doktorsavhandling Ämnade för restaurangarbete? - Om politisk styrning och lågutbildade ungdomars väg fram till arbetsmarknadens tröskel; Erik Sjödin recenserar Rasmus Hästbackas licentiatavhandling Europeiska företagsråd i svenska koncerner: En rättsvetenskaplig studie av EWC-regleringens betydelse för arbetstagarinflytande och styrning.

  • Lithberg, Nils
    Nordiska museet.
    Bröllopsseder på Gottland1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 129-148Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Levander, Lars
    Nordiska museet.
    Fyra sånger från Älfdalen1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 125-128Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Flentzberg, Ant
    Nordiska museet.
    Spott och spottning1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 105-125Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Lindholm-Dahlstrand, Åsa
    et al.
    Lund University.
    Andersson, Martin
    Blekinge Tekniska Högskola, Fakulteten för teknikvetenskaper, Institutionen för industriell ekonomi.
    Carlsson, Bo
    Case Western Reserve University, Cleveland.
    Entrepreneurial experimentation: a key function in systems of innovation2018Inngår i: Small Business Economics, ISSN 0921-898X, E-ISSN 1573-0913, s. 1-20Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The literature on innovation systems focuses on the supply side (the creation of technology) rather than on how innovations are converted into economic activity and growth via the market (the demand side, and the interface between supply and demand). One implication of this is that there is a dearth of research on the links between innovation systems and economic growth. The purpose of this paper is to begin to fill this gap in the literature. We articulate the function of entrepreneurial experimentation as an essential mechanism for translating new knowledge into economic activity and growth created in innovation systems. We argue that entrepreneurial experimentation comprises both “technical” and “market” experimentation. Spinoffs and acquisitions are proposed as micro-mechanisms that give rise to system-wide entrepreneurial experimentation. Our framework suggests that entrepreneurial experimentation is central in driving both the supply- and the demand-side dynamics of innovation systems, hence linking both innovation systems and entrepreneurship to economic growth. © 2018 The Author(s)

  • Lundström, Ulf
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för tillämpad utbildningsvetenskap.
    Lärares professionella autonomi under New Public Management-epoken2018Inngår i: Utbildning och Demokrati, ISSN 1102-6472, E-ISSN 2001-7316, Vol. 27, nr 1, s. 33-59Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Teachers’ Professional Autonomy During the New Public Management Epoch. The last few decades of intensive school reform has affected and continue to affect teachers’ work and the construction of the teaching profession. This article examines how upper secondary school teachers perceive and respond to the consequences for their professional autonomy of recent school reforms and restructurings. Based on empirical material from interviews of 119 teachers in three studies conducted between 2002 and 2014, the findings indicate that teacher autonomy has been reduced by school reforms and restructurings since the late 1980s. Most of these policies are neo-liberal policies or New Public Management technologies. The findings testify to the on-going emphasis on the significance of market logics as well as on how these work together with bureaucratic logics to shift occupational professionalism to organizational professionalism and licensed autonomy to regulated autonomy.

    Teachers’ Professional Autonomy During the New Public Management Epoch. The last few decades of intensive school reform has affected and continue to affect teachers’ work and the construction of the teaching profession. This article examines how upper secondary school teachers perceive and respond to the consequences for their professional autonomy of recent school reforms and restructurings. Based on empirical material from interviews of 119 teachers in three studies conducted between 2002 and 2014, the findings indicate that teacher autonomy has been reduced by school reforms and restructurings since the late 1980s. Most of these policies are neo-liberal policies or New Public Management technologies. The findings testify to the on-going emphasis on the significance of market logics as well as on how these work together with bureaucratic logics to shift occupational professionalism to organizational professionalism and licensed autonomy to regulated autonomy.

  • Hammarstedt, N E
    Nordiska museet.
    Inspirationfågeln1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 83-104Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Keyland, Nils
    Nordiska museet.
    Skärning och snesning: Bilder och anteckningar från Mangskogs socken, Värmland, och dess omnejd.1908Inngår i: Fataburen – Kulturhistorisk tidskrift, Stockholm: Nordiska museets förlag, 1908, s. 65-82Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Syvänen, Stina
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Hultqvist, Greta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Gustavsson, Tobias
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Gumucio, Astrid
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Laudon, Hanna
    BioArctic AB, Stockholm, Sweden.
    Söderberg, Linda
    BioArctic AB, Stockholm, Sweden.
    Ingelsson, Martin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Lannfelt, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik. BioArctic AB, Stockholm, Sweden.
    Sehlin, Dag
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Efficient clearence of A beta protofibrils in A beta PP-transgenic mice treated with a brain-penetrating bifunctional antibody2018Inngår i: Alzheimer's Research & Therapy, ISSN 0065-6755, E-ISSN 1758-9193, Vol. 10, artikkel-id 49Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Amyloid-beta (A beta) immunotherapy is one of the most promising disease-modifying strategies for Alzheimer's disease (AD) Despite recent progress targeting aggregated forms of A beta, low antibody brain penetrance remains a challenge In the piesent study, we used transferrin receptor (TfR)-mediated transcytosis to facilitate brain uptake of our previously developed A beta protofibril-selective mAb158, with the aim of increasing the efficacy of immunotherapy directed toward soluble A beta protofibills. Methods: A beta protein precursor (A beta PP)-transgenic mice (tg-ArcSwe) were given a single dose of mAb158, modified for TfR-mediated transcytosis (RmAb158-scFvSDB), in companson with an equimolar dose or a tenfold higher dose of unmodified recombinant mAb158 (RmAb158) Soluble A beta protofibrills and total A beta in the brain were measured by enzyme-linked immunosorbent assay (ELISA) Brain distribution of radiolabeled antibodies was visualized by positron emission tomography (PET) and ex vivo autoiadiography. Results: ELISA analysis of Tris-buffered saline brain extracts demonstrated a 40% reduction of soluble A beta protofibrils in both RmAb158-scFv8D3- and high-dose RmAb158-treated mice, whereas there was no A beta protofibril reduction in mice treated with a low dose of RmAb158. Further, ex vivo autoradiography and PET imaging revealed diffeient brain distribution patterns of RmAb158-scFv8D3 and RmAb158, suggesting that these antibodies may affect A beta levels by different mechanisms. Conclusions: With a combination of biochemical and imaging analyses, this study demonstrates that antibodies engineered to be transported across the blood brain barrier can be used to increase the efficacy of A beta immunotherapy. This strategy may allow for decreased antibody doses and thereby reduced side effects and treatment costs.

  • Husek, Tomas
    et al.
    Charles Univ Prague, Fac Math & Phys, Inst Particle & Nucl Phys, V Holesovickach 2, Prague 8, Czech Republic;Univ Birmingham, Sch Phys & Astron, Birmingham B15 2TT, W Midlands, England.
    Kampf, Karol
    Charles Univ Prague, Fac Math & Phys, Inst Particle & Nucl Phys, V Holesovickach 2, Prague 8, Czech Republic.
    Novotny, Jiri
    Charles Univ Prague, Fac Math & Phys, Inst Particle & Nucl Phys, V Holesovickach 2, Prague 8, Czech Republic.
    Leupold, Stefan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Kärnfysik.
    Radiative corrections to the η(') Dalitz decays2018Inngår i: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 97, nr 9, artikkel-id 096013Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We provide the complete set of radiative corrections to the Dalitz decays eta(()'()) -> l(+)l(-)gamma beyond the softphoton approximation, i. e., over the whole range of the Dalitz plot and with no restrictions on the energy of a radiative photon. The corrections inevitably depend on the eta(()'()) -> gamma*gamma(*) transition form factors. For the singly virtual transition form factor appearing, e.g., in the bremsstrahlung correction, recent dispersive calculations are used. For the one-photon-irreducible contribution at the one-loop level (for the doubly virtual form factor), we use a vector-meson-dominance-inspired model while taking into account the eta-eta' mixing.

  • Björnson, Kristofer
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori. Univ Copenhagen, Niels Bohr Inst, Juliane Maries Vej 30, DK-2100 Copenhagen, Denmark.
    Black-Schaffer, Annica M.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Materialteori.
    Solid-state Stern-Gerlach spin splitter for magnetic field sensing, spintronics, and quantum computing2018Inngår i: Beilstein Journal of Nanotechnology, ISSN 2190-4286, Vol. 9, s. 1558-1563Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We show conceptually that the edge of a two-dimensional topological insulator can be used to construct a solid-state Stern-Gerlach spin splitter. By threading such a Stern-Gerlach apparatus with a magnetic flux, Aharanov-Bohm-like interference effects are introduced. Using ferromagnetic leads, the setup can be used to both measure magnetic flux and as a spintronics switch. With normal metallic leads a switchable spintronics NOT-gate can be implemented. Furthermore, we show that a sequence of such devices can be used to construct a single-qubit SU(2)-gate, one of the two gates required for a universal quantum computer. The field sensitivity, or switching field, b, is related to the characteristic size of the device, r, through b = h/(2 pi qr(2)), with q being the unit of electric charge.

  • Vlemmings, W. H. T.
    et al.
    Chalmers Univ Technol, Onsala Space Observ, Dept Space Earth & Environm, S-43992 Onsala, Sweden.
    Khouri, T.
    Chalmers Univ Technol, Onsala Space Observ, Dept Space Earth & Environm, S-43992 Onsala, Sweden.
    De Beck, E.
    Chalmers Univ Technol, Onsala Space Observ, Dept Space Earth & Environm, S-43992 Onsala, Sweden.
    Olofsson, H.
    Chalmers Univ Technol, Onsala Space Observ, Dept Space Earth & Environm, S-43992 Onsala, Sweden.
    Garcia-Segura, G.
    Univ Nacl Autonoma Mexico, Inst Astron, Km 107 Carr Tijuana Ensenada, Ensenada 22860, BC, Mexico.
    Villaver, E.
    Univ Autonoma Madrid, Dept Fis Teor, E-28049 Madrid, Spain.
    Baudry, A.
    Univ Bordeaux, CNRS, Lab Astrophys Bordeaux, B18N, Allee Geoffroy St Hilaire, F-33615 Pessac, France.
    Humphreys, E. M. L.
    European Southern Observ, Karl Schwarzschild Str 2, D-85748 Garching, Germany.
    Maercker, M.
    Chalmers Univ Technol, Onsala Space Observ, Dept Space Earth & Environm, S-43992 Onsala, Sweden.
    Ramstedt, Sofia
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi.
    Rotation of the asymptotic giant branch star R Doradus2018Inngår i: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 613, artikkel-id L4Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    High-resolution observations of the extended atmospheres of asymptotic giant branch (AGB) stars can now directly be compared to the theories that describe stellar mass loss. Using Atacama Large Millimeter/submillimeter Array (ALMA) high angular resolution (30 x 42 mas) observations, we have for the first time resolved stellar rotation of an AGB star, R Dor. We measure an angular rotation velocity of omega(R) sin i = (3.5 +/- 0.3) x 10(-9) rad s(-1), which indicates a rotational velocity of vertical bar nu(rot) sin i vertical bar = 1.0 +/- 0.1 km s(-1) at the stellar surface (R-* = 31.2 mas at 214 GHz). The rotation axis projected on the plane of the sky has a position angle Phi = 7 +/- 6 degrees. We find that the rotation of R Dor is two orders of magnitude faster than expected for a solitary AGB star that will have lost most of its angular momentum. Its rotational velocity is consistent with angular momentum transfer from a close companion. As a companion has not been directly detected, we suggest R Dor has a low-mass, close-in companion. The rotational velocity approaches the critical velocity, set by the local sound speed in the extended envelope, and is thus expected to affect the mass-loss characteristics of R Dor.