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  • Metson, Genevieve S.
    et al.
    Department of Natural Resource Sciences, McGill University, 21,111 Lakeshore Road, Sainte Anne de Bellevue, QC, Canada.
    Bennett, Elena M.
    Department of Natural Resource Sciences, McGill University, 21,111 Lakeshore Road, Sainte Anne de Bellevue, QC, Canada / McGill School of Environment, McGill University, 3534 University Street, Montreal, QC, Canada .
    Elser, James J.
    School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, USA.
    The role of diet in phosphorus demand2012Inngår i: Environmental Research Letters, ISSN 1748-9326, E-ISSN 1748-9326, Vol. 7, nr 4, s. 1-10, artikkel-id 044043Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Over the past 50 years, there have been major changes in human diets, including a global average increase in meat consumption and total calorie intake. We quantified how changes in annual per capita national average diets affected requirements for mined P between 1961 and 2007, starting with the per capita availability of a food crop or animal product and then determining the P needed to grow the product. The global per capita P footprint increased 38% over the 46 yr time period, but there was considerable variability among countries. Phosphorus footprints varied between 0.35 kg P capita −1 yr −1 (DPR Congo, 2007) and 7.64 kg P capita −1 yr −1 (Luxembourg, 2007). Temporal trends also differed among countries; for example, while China’s P footprint increased almost 400% between 1961 and 2007, the footprints of other countries, such as Canada, decreased. Meat consumption was the most important factor affecting P footprints; it accounted for 72% of the global average P footprint. Our results show that dietary shifts are an important component of the human amplification of the global P cycle. These dietary trends present an important challenge for sustainable P management.

  • Takman, Johanna
    et al.
    Statens väg- och transportforskningsinstitut, Samhälle, miljö och transporter, SAMT, Transportekonomi, TEK.
    Andersson-Sköld, Yvonne
    Statens väg- och transportforskningsinstitut, Samhälle, miljö och transporter, SAMT, Miljö, MILJÖ.
    Johansson, Jessica
    Statens väg- och transportforskningsinstitut, Samhälle, miljö och transporter, SAMT, Miljö, MILJÖ.
    Johansson, Magnus
    Statens väg- och transportforskningsinstitut, Samhälle, miljö och transporter, SAMT, Transportekonomi, TEK.
    Johansson, Hannele
    Energikontor Sydost.
    Uhlin, Lovisa
    Regional utveckling Örebro län.
    Kantelius, Åslög
    Region Jönköpings län.
    Biogas för tunga lastbilstransporter: barriärer och möjligheter2018Rapport (Annet vitenskapelig)
    Abstract [sv]

    I denna rapport presenterar vi en fördjupad studie av vilka barriärer och möjligheter som finns för biogas, och framförallt flytande biogas (LBG), för tunga lastbilar i större skala samt hur barriärerna övervinns och möjligheterna nyttjas. Studien identifierar även viktiga varuägare och andra intressenter i Sverige samt vilka krav och villkor dessa ställer för att våga investera i gastekniken. För att besvara studiens frågeställningar genomfördes en genomgång av litteraturen samt intervjuer och workshops med relevanta aktörer. Resultaten pekar på att biogasen är ett drivmedel som kan bidra till minskade koldioxidutsläpp. Vidare nämns även drivkrafter som energitrygghet och en cirkulär ekonomi. Att det nu har kommit nya tunga LBG-lastbilar på marknaden samt att nya styrmedel trätt i kraft ses också som drivkrafter. Avsaknaden av långsiktiga, stabila styrmedel och regelverk samt höga priser och kostnader för exempelvis produktion, fordon och gas angavs vara de största barriärerna. Ytterligare barriärer är exempelvis att det råder kunskapsbrist inom området samt att dagens förnybara drivmedel konkurrerar med varandra istället för att komplettera varandra.

    Det behövs en ökad långsiktighet i styrmedel som gynnar de mest hållbara förnybara bränslen som finns idag. Det behövs också att svenska styrmedel harmoniseras med styrmedel inom övriga EU på ett bättre sätt än de som funnits fram till idag. Det behövs även ökade möjligheter till stöd som exempelvis gynnar produktionen av biogas, investeringsstöd till de fordon som bäst gynnar att klimatoch andra miljömål nås, samt stöd som inkluderar andrahandsmarknaden för dessa fordon för att påverka marknaden mot en mer miljömässigt hållbar transportsektor. Det behövs informationsinsatser för att informera om biogas i förhållande till andra drivmedel för tunga lastbilar och information om att, samt var, dagens tankstationer för LBG finns. Även demonstrationsprojekt som visar fordonen ute på vägarna samt bidrar till infrastrukturutvecklingen skulle kunna hjälpa till att sprida kunskap och visa att tekniken fungerar och på så sätt utveckla marknaden för LBG.

  • Lampa, Erik
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR).
    Eguchi, Akifumi
    Chiba Univ, Ctr Prevent Med Sci, Chiba, Japan.
    Todaka, Emiko
    Chiba Univ, Ctr Prevent Med Sci, Chiba, Japan.
    Mori, Chisato
    Chiba Univ, Ctr Prevent Med Sci, Chiba, Japan.
    Fetal exposure markers of dioxins and dioxin-like PCBs2018Inngår i: Environmental science and pollution research international, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 25, nr 12, s. 11940-11947Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Fetal exposure to polychlorinated biphenyls (PCBs), polychlorinated-p-dibenzodioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) have been associated with a number of adverse health outcomes. Although the placenta acts as a barrier between the mother and the fetus, these contaminants transfer through the placenta exposing the fetus. Several studies have investigated placental transfer, but few have assessed the co-variation among these contaminants. Maternal blood, cord blood, and cord tissue were collected from 41 Japanese mother-infant pairs and analyzed for dioxin-like PCBs and PCDD/Fs. Hierarchical cluster analysis followed by principal component analysis were used to assess the co-variation. Two stable clusters of dioxin-like PCBs were found in maternal and cord blood. One cluster of low/medium chlorinated dioxin-like PCBs was present in all three matrices with 2,3',4,4',5-PeCB(#118) and 3,3',4,4',5-PeCB(#126) explaining the majority of the clusters' variances. Medium/high chlorinated dioxin-like PCBs clustered in maternal blood and cord blood but not in cord tissue. 2,3,4,4',5-PeCB(#114) and 2,3,3',4,4',5,5'-HpCB(#189) explained the majority of the clusters' variances. There was a substantial correlation between the sum of dioxin-like PCBs and total PCDD/F in all three matrices. The sum of the four suggested PCBs plus 3,3',4,4'-TeCB(#77) correlated well with total PCDD/F in all three matrices. Apart from the dioxin-like PCBs, little co-variation existed among the studied contaminants. The five PCBs can be used as fetal exposure markers for dioxin and dioxin-like PCBs in maternal and cord blood respectively. In cord tissue, more higher chlorinated dioxin-like PCBs need to be measured as well.

  • van den Besselaar, Peter
    et al.
    Nederländerna.
    Sandström, Ulf
    KTH, Skolan för industriell teknik och management (ITM), Industriell ekonomi och organisation (Inst.), Hållbarhet och industriell dynamik.
    Schiffbaenker, Hélène
    Österrike.
    Studying grant decision-making: a linguistic analysis of review reports2018Inngår i: Scientometrics, ISSN 0138-9130, E-ISSN 1588-2861, Vol. 118, nr 1, s. 313-329Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Peer and panel review are the dominant forms of grant decision-making, despite its serious weaknesses as shown by many studies. This paper contributes to the understanding of the grant selection process through a linguistic analysis of the review reports. We reconstruct in that way several aspects of the evaluation and selection process: what dimensions of the proposal are discussed during the process and how, and what distinguishes between the successful and non-successful applications? We combine the linguistic findings with interviews with panel members and with bibliometric performance scores of applicants. The former gives the context, and the latter helps to interpret the linguistic findings. The analysis shows that the performance of the applicant and the content of the proposed study are assessed with the same categories, suggesting that the panelists actually do not make a difference between past performance and promising new research ideas. The analysis also suggests that the panels focus on rejecting the applications by searching for weak points, and not on finding the high-risk/high-gain groundbreaking ideas that may be in the proposal. This may easily result in sub-optimal selections, in low predictive validity, and in bias.

  • Michaels, Hannes
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi.
    Benesperi, Iacopo
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi.
    Edvinsson, Tomas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets fysik.
    Munoz-Garcia, Ana Belen
    Univ Naples Federico II, Dept Phys Ettore Pancini, I-80126 Naples, Italy.
    Pavone, Michele
    Univ Naples Federico II, Dept Chem Sci, I-80126 Naples, Italy.
    Boschloo, Gerrit
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi. Uppsala Univ, Dept Chem, Angstrom Lab, POB 523, SE-75120 Uppsala, Sweden.
    Freitag, Marina
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi.
    Copper Complexes with Tetradentate Ligands for Enhanced Charge Transport in Dye-Sensitized Solar Cells2018Inngår i: INORGANICS, ISSN 2304-6740, Vol. 6, nr 2, artikkel-id 53Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In dye-sensitized solar cells (DSCs), the redox mediator is responsible for the regeneration of the oxidized dye and for the hole transport towards the cathode. Here, we introduce new copper complexes with tetradentate 6,6-bis(4-(S)-isopropyl-2-oxazolinyl)-2,2-bipyridine ligands, Cu(oxabpy), as redox mediators. Copper coordination complexes with a square-planar geometry show low reorganization energies and thus introduce smaller losses in photovoltage. Slow recombination kinetics of excited electrons between the TiO2 and Cu-II(oxabpy) species lead to an exceptionally long electron lifetime, a high Fermi level in the TiO2, and a high photovoltage of 920 mV with photocurrents of 10 mA.cm(-2) and 6.2% power conversion efficiency. Meanwhile, a large driving force remains for the dye regeneration of the Y123 dye with high efficiencies. The square-planar Cu(oxabpy) complexes yield viscous gel-like solutions. The unique charge transport characteristics are attributed to a superposition of diffusion and electronic conduction. An enhancement in charge transport performance of 70% despite the higher viscosity is observed upon comparison of Cu(oxabpy) to the previously reported Cu(tmby)(2) redox electrolyte.

  • Guwatudde, David
    et al.
    Makerere Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Coll Hlth Sci, Kampala, Uganda.
    Absetz, Pilvikki
    Collaborat Care Syst Finland, Helsinki, Finland.
    Delobelle, Peter
    Univ Cape Town, Chron Dis Initiat Africa, Cape Town, South Africa;Univ Western Cape, Sch Publ Hlth, Cape Town, South Africa.
    Ostenson, Claes-Goran
    Karolinska Inst, Dept Mol Med & Surg, Diabet & Endocrine Unit, Stockholm, Sweden.
    Van, Josefien Olmen
    Inst Trop Med, Dept Publ Hlth, Antwerp, Belgium.
    Alvesson, Helle Molsted
    Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
    Mayega, Roy William
    Makerere Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Coll Hlth Sci, Kampala, Uganda.
    Kiracho, Elizabeth Ekirapa
    Makerere Univ, Sch Publ Hlth, Coll Hlth Sci, Dept Hlth Policy Planning & Management, Kampala, Uganda.
    Kiguli, Juliet
    Makerere Univ, Dept Community Hlth & Behav Sci, Sch Publ Hlth, Kampala, Uganda.
    Sundberg, Carl Johan
    Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden;Karolinska Inst, Dept Learning Informat Management & Eth, Stockholm, Sweden.
    Sanders, David
    Univ Western Cape, Sch Publ Hlth, Cape Town, South Africa.
    Tomson, Goran
    Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden;Royal Acad Sci, SIGHT, Stockholm, Sweden.
    Puoane, Thandi
    Univ Western Cape, Sch Publ Hlth, Cape Town, South Africa.
    Peterson, Stefan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH). Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
    Daivadanam, Meena
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för kostvetenskap. Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
    Study protocol for the SMART2D adaptive implementation trial: a cluster randomised trial comparing facility-only care with integrated facility and community care to improve type-2 diabetes outcomes in Uganda, South Africa and Sweden2018Inngår i: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 8, nr 3, artikkel-id e019881Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction Type 2 diabetes (T2D) is increasingly contributing to the global burden of disease. Health systems in most parts of the world are struggling to diagnose and manage T2D, especially in low-income and middle-income countries, and among disadvantaged populations in high-income countries. The aim of this study is to determine the added benefit of community interventions onto health facility interventions, towards glycaemic control among persons with diabetes, and towards reduction in plasma glucose among persons with prediabetes. Methods and analysis An adaptive implementation cluster randomised trial is being implemented in two rural districts in Uganda with three clusters per study arm, in an urban township in South Africa with one cluster per study arm, and in socially disadvantaged suburbs in Stockholm, Sweden with one cluster per study arm. Clusters are communities within the catchment areas of participating primary healthcare facilities. There are two study arms comprising a facility plus community interventions arm and a facility-only interventions arm. Uganda has a third arm comprising usual care. Intervention strategies focus on organisation of care, linkage between health facility and the community, and strengthening patient role in self-management, community mobilisation and a supportive environment. Among T2D participants, the primary outcome is controlled plasma glucose; whereas among prediabetes participants the primary outcome is reduction in plasma glucose. Ethics and dissemination The study has received approval in Uganda from the Higher Degrees, Research and Ethics Committee of Makerere University School of Public Health and from the Uganda National Council for Science and Technology; in South Africa from the Biomedical Science Research Ethics Committee of the University of the Western Cape; and in Sweden from the Regional Ethical Board in Stockholm. Findings will be disseminated through peer-reviewed publications and scientific meetings.

  • Disputas: 2018-10-05 13:15 12A138 Geijer, Karlstad
    Ferrer Conill, Raul
    Karlstads universitet, Fakulteten för humaniora och samhällsvetenskap (from 2013), Institutionen för geografi, medier och kommunikation (from 2013).
    Gamifying the news: Exploring the introduction of game elements into digital journalism2018Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    For over a century, crosswords, puzzles, and quizzes have been present in newspapers. Digital journalism has only increased the trend of integrating game elements in news media, often blurring the traditional boundaries between news and games.

    This dissertation aims to explore and understand how and why news organizations and newsworkers use gamification in digital news websites and to analyze the objectives behind its implementation in news production. The importance of trying to understand this development stems from the different roles that digital games and news have in contemporary democratic societies. While journalism is often regarded as the main source of information for the public to act as citizens, digital games predominantly remain considered as entertainment media.

    Drawing from media sociology and new institutionalism, this study engages with the literature on converging processes of popularization and professionalization of journalism, and how different institutional logics of gamification and journalism interact. Methodologically, this qualitative multiple case study analyzes four diverse news organizations (the Guardian, Bleacher Report, the Times of India, and Al Jazeera), interviewing 56 newsworkers, and conducting game-system analysis of their respective gamified systems.

    The findings suggest that while news organizations often frame their motivations within the celebratory rhetoric of gamification, a deeper look into the material manifestations of gamified news systems tend to problematize the empowering claims of gamification. Instead, a complex interplay between the professional and commercial logics of journalism and the hedonic and utilitarian logics of gamification shapes how news organizations and newsworkers implement gamified systems. This dissertation contributes to a larger debate on the friction professionalism and the market, on institutional interaction, and the increasing transgression of journalistic institutional borders.

  • Campos-Beltran, Diana
    et al.
    Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, Ratzeburger Allee 160, D-23562 Lubeck, Germany.
    Konradsson-Geuken, Åsa
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap. Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
    Quintero, Jorge E.
    Univ Kentucky, CenMeT, Lexington, KY 40506 USA;Quanteon LLC, Nicholasville, KY 40356 USA.
    Marshall, Lisa
    Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, Ratzeburger Allee 160, D-23562 Lubeck, Germany.
    Amperometric Self-Referencing Ceramic Based Microelectrode Arrays for D-Serine Detection2018Inngår i: Biosensors, ISSN 2079-6374, Vol. 8, nr 1, artikkel-id 20Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    D-serine is the major D-amino acid in the mammalian central nervous system. As the dominant co-agonist of the endogenous synaptic NMDA receptor, D-serine plays a role in synaptic plasticity, learning, and memory. Alterations in D-serine are linked to neuropsychiatric disorders including schizophrenia. Thus, it is of increasing interest to monitor the concentration of D-serine in vivo as a relevant player in dynamic neuron-glia network activity. Here we present a procedure for amperometric detection of D-serine with self-referencing ceramic-based microelectrode arrays (MEAs) coated with D-amino acid oxidase from the yeast Rhodotorula gracilis (RgDAAO). We demonstrate in vitro D-serine recordings with a mean sensitivity of 8.61 +/- 0.83 pA/mu M to D-serine, a limit of detection (LOD) of 0.17 +/- 0.01 mu M, and a selectivity ratio of 80:1 or greater for D-serine over ascorbic acid (mean +/- SEM; n = 12) that can be used for freely moving studies.

  • Dimenäs, Jörgen
    Högskolan Dalarna, Akademin Utbildning, hälsa och samhälle, Naturvetenskap.
    Science teaching - scientific literacy in a school perspective2018Inngår i: International Journal of Advance Research in Education and Literature, ISSN 2208-2441, Vol. 4, nr 4, s. 1-11Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The article highlights professional teachers' understandingsof what they see as the mostimportant contentin science education. The study is based on conversations with professional teachers andexplorehow they understand what isthe most central contentin science education. Their understandingsare related to the importance of science in the society and to the language's importance to students' learning opportunities. The resultsof the study's interviews are analyzed usingBasil Bernstein's concept of the horizontal and vertical discourseas a framework, which demonstrates the opportunities for pupils toapproachscientific content based on a contextual understanding. How science is taught is an important question in the aspect of students comingfrom different socioeconomic conditions and withdifferent conceptions of the outside world and the science schooldiscourse. In the present study professional teachersstressthe importance of a holistic understanding of the content in science, the methodical aspects in science educationandtheconsequencesof science and technology developmentin particular. Tobe science literatein a classroomcontext means that the students will get the capacity to use scientific knowledge, to identifyquestions and to draw evidencebased conclusions in order to understand and help make decisions about the natural world and the changes made to it through human activity.

  • Metson, Genevieve
    et al.
    Arizona State University, USA.
    Wyant, Karl A.
    School of Life Sciences, Arizona State Univeristy, Tempe, USA.
    Childers, Daniel L.
    School of Sustainability, Arizona State University, Tempe, USA.
    Introduction to P Sustainability: P is for Philosophy and Process2013Inngår i: Phosphorus, Food, and Our Future / [ed] Karl A. Wyant, Jessica R. Corman, and James J. Elser, Oxford University Press, 2013, s. 1-19Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    This chapter illustrates and explains the basic principles of sustainability. It provides a sustainability framework to existing issues in phosphorous management. It summarizes human impacts on natural phosphorus cycling and the identification of phosphorus sustainability as a "wicked problem". It describes how a sustainability perspective contributes to shaping appropriate solutions to phosphorus management. It also enumerates the general approach of every chapter in connecting various aspects of human use of phosphorous to a sustainability framework. Introduction to P Sustainability: P is for Philosophy and Process.

  • Dimenäs, Jörgen
    Högskolan Dalarna, Akademin Utbildning, hälsa och samhälle, Naturvetenskap.
    Teaching in action: A model to understand the complexity of teachers´decisions in teaching mathematics2018Inngår i: International Journal of Advance Research in Education and Literature, ISSN 2208-2441, Vol. 4, nr 1, s. 10-24Artikkel i tidsskrift (Fagfellevurdert)
  • Kang, Naixin
    et al.
    Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacognosy, Suzhou 215123, Peoples R China.
    Shen, Wenhua
    Jiangxi Univ Tradit Chinese Med, Coll Pharmaceut Sci, Nanchang 330006, Jiangxi, Peoples R China.
    Gao, Hongwei
    Guangxi Univ Chinese Med, Coll Pharm, Nanning 530001, Peoples R China.
    Feng, Yulin
    Jiangxi Univ Tradit Chinese Med, Coll Pharmaceut Sci, Nanchang 330006, Jiangxi, Peoples R China.
    Zhu, Weifeng
    Jiangxi Univ Tradit Chinese Med, Coll Pharmaceut Sci, Nanchang 330006, Jiangxi, Peoples R China.
    Yang, Shilin
    Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacognosy, Suzhou 215123, Peoples R China;Jiangxi Univ Tradit Chinese Med, Coll Pharmaceut Sci, Nanchang 330006, Jiangxi, Peoples R China.
    Liu, Yanli
    Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacol, Suzhou 215123, Peoples R China.
    Xu, Qiongming
    Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacognosy, Suzhou 215123, Peoples R China.
    Yu, Di
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis2018Inngår i: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 23, nr 6, artikkel-id 1431Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Schistosomiasis is a major neglected disease for which the current control strategy involves mass treatment with praziquantel, the only available drug. Hence, there is an urgent need to develop new antischistosomal compounds.

    Methods: The antischistosomal activity of hederacolchiside A1 (HSA) were determined by total or female worm burden reductions in mice harboring Schistosoma japonicum or S. mansoni. Pathology parameters were detected on HSA against 1-day-old S. japonicum-harboring mice. Moreover, we confirmed the antischistosomal effect of HSA on newly transformed schistosomula (NTS) of S. japonicum in vitro.

    Results: HSA, a natural product isolated from Pulsatilla chinensis (Bunge) Regel, was initially corroborated to possess promising antischistosomal properties. We demonstrated that HSA had high activity against S. japonicum and S. mansoni less in 11 days old parasites harbored in mice. The antischistosomal effect was even more than the currently used drugs, praziquantel, and artesunate. Furthermore, HSA could ameliorate the pathology parameters in mice harboring 1-day-old juvenile S. japonicum. We also confirmed that HSA-mediated antischistosomal activity is partly due to the morphological changes in the tegument system when NTS are exposed to HSA.

    Conclusions: HSA may have great potential to be an antischistosomal agent for further research.

  • Golwala, Harsh B.
    et al.
    Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA USA.
    Cannon, Christopher P.
    Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA USA; Baim Inst Clin Res, Boston, MA USA.
    Steg, Ph. Gabriel
    FACT, Boston, MA USA; Univ Paris Diderot, Hop Bichat, AP HP, Paris, France; INSERM, Paris, France.
    Doros, Gheorghe
    Baim Inst Clin Res, Boston, MA USA; Boston Univ, Sch Publ Hlth, Dept Biostat, Crosstown Ctr, Boston, MA USA.
    Qamar, Arman
    Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA USA.
    Ellis, Stephen G.
    Cleveland Clin, Dept Cardiovasc Med, Cleveland, OH USA.
    Oldgren, Jonas
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR).
    ten Berg, Jurrien M.
    St Antonius Hosp Nieuwegein, Dept Cariol, CM Nieuwegein, Netherlands.
    Kimura, Takeshi
    Kyoto Univ Hosp, Dept Cardiovasc Med, Kyoto, Kyoto, Japan.
    Hohnloser, Stefan H.
    Goethe Univ Frankfurt, Div Cardiac Electrophysiol, Dept Cardiol, Frankfurt, Germany.
    Lip, Gregory Y. H.
    Univ Birmingham, Inst Cardiovasc Sci, Birmingham, W Midlands, England.
    Bhatt, Deepak L.
    Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA USA.
    Safety and efficacy of dual vs. triple antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: a systematic review andmeta-analysis of randomized clinical trials2018Inngår i: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 39, nr 19, s. 1726-+Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Aims: Of patients with atrial fibrillation (AF), approximately 10% undergo percutaneous coronary intervention (PCI). We studied the safety and efficacy of dual vs. triple antithrombotic therapy (DAT vs. TAT) in this population.

    Methods and results: A systematic review and meta-analysis was conducted using PubMed, Embase, EBSCO, Cochrane database of systematic reviews, Web of Science, and relevant meeting abstracts for Phase 3, randomized trials that compared DAT vs. TAT in patients with AF following PCI. Four trials including 5317 patients were included, of whom 3039 (57%) received DAT. Compared with the TAT arm, Thrombolysis in Myocardial Infarction (TIMI) major or minor bleeding showed a reduction by 47% in the DAT arm [4.3% vs. 9.0%; hazard ratio (HR) 0.53, 95% credible interval (CrI) 0.36–0.85, I2 = 42.9%]. In addition, there was no difference in the trial-defined major adverse cardiac events (MACE) (10.4% vs. 10.0%, HR 0.85, 95% CrI 0.48–1.29, I2 = 58.4%), or in individual outcomes of all-cause mortality, cardiac death, myocardial infarction, stent thrombosis, or stroke between the two arms.

    Conclusion: Compared with TAT, DAT shows a reduction in TIMI major or minor bleeding by 47% with comparable outcomes of MACE. Our findings support the concept that DAT may be a better option than TAT in many patients with AF following PCI.

  • Brussee, Janneke M.
    et al.
    Leiden Univ, LACDR, Div Syst Biomed & Pharmacol, Leiden, Netherlands.
    Yu, Huixin
    Leiden Univ, LACDR, Div Syst Biomed & Pharmacol, Leiden, Netherlands.
    Krekels, Elke H. J.
    Leiden Univ, LACDR, Div Syst Biomed & Pharmacol, Leiden, Netherlands.
    de Roos, Berend
    Leiden Univ, LACDR, Div Syst Biomed & Pharmacol, Leiden, Netherlands.
    Brill, Margreke JE
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    van den Anker, Johannes N.
    Univ Basel, Childrens Hosp, Div Paediat Pharmacol & Pharmacometr, Basel, Switzerland;Sophia Childrens Univ Hosp, Erasmus MC, Intens Care & Dept Pediat Surg, Rotterdam, Netherlands;Childrens Natl Hlth Syst, Div Clin Pharmacol, Washington, DC USA.
    Rostami-Hodjegan, Amin
    Simcyp Ltd, Sheffield, S Yorkshire, England;Univ Manchester, Ctr Appl Pharmacokinet Res, Manchester, Lancs, England.
    de Wildt, Saskia N.
    Radboud Univ Nijmegen, Dept Pharmacol & Toxicol, Med Ctr, Nijmegen, Netherlands;Sophia Childrens Univ Hosp, Erasmus MC, Intens Care & Dept Pediat Surg, Rotterdam, Netherlands.
    Knibbe, Catherijne A. J.
    Leiden Univ, LACDR, Div Syst Biomed & Pharmacol, Leiden, Netherlands;St Antonius Hosp, Dept Clin Pharm, Nieuwegein, Netherlands.
    First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates2018Inngår i: CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, ISSN 2163-8306, Vol. 7, nr 6, s. 374-383Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    To predict first-pass and systemic cytochrome P450 (CYP) 3A-mediated metabolism of midazolam in preterm neonates, a physiological population pharmacokinetic model was developed describing intestinal and hepatic midazolam clearance in preterm infants. On the basis of midazolam and 1-OH-midazolam concentrations from 37 preterm neonates (gestational age 26-34 weeks) receiving midazolam orally and/or via a 30-minute intravenous infusion, intrinsic clearance in the gut wall and liver were found to be very low, with lower values in the gut wall (0.0196 and 6.7 L/h, respectively). This results in a highly variable and high total oral bioavailability of 92.1% (range, 67-95%) in preterm neonates, whereas this is around 30% in adults. This approach in which intestinal and hepatic clearance were separately estimated shows that the high bioavailability in preterm neonates is explained by, likely age-related, low CYP3A activity in the liver and even lower CYP3A activity in the gut wall.

  • Lagerquist, Marshall
    Nordiska museet.
    En kanna med Erik XIVs bild1941Inngår i: Fataburen - Nordiska Museet och Skansens Årsbok, Stockholm: Nordiska museets förlag, 1941, s. 227-230Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Homman, Olle
    Nordiska museet.
    Kista från Lillhärdal1941Inngår i: Fataburen - Nordiska Museet och Skansens Årsbok, Stockholm: Nordiska museets förlag, 1941, s. 224-226Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Strömberg, Elisabeth
    Nordiska museet.
    Den spelande haren eller Kung david med harpan1941Inngår i: Fataburen - Nordiska Museet och Skansens Årsbok, Stockholm: Nordiska museets förlag, 1941, s. 222-223Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Nerhagen, Lena
    et al.
    Statens väg- och transportforskningsinstitut, Samhälle, miljö och transporter, SAMT, Transportekonomi, TEK.
    Andersson-Sköld, Yvonne
    Statens väg- och transportforskningsinstitut, Samhälle, miljö och transporter, SAMT, Miljö, MILJÖ.
    Emissioner från flyg inom svenskt luftrum och externa kostnader för dessa: en delrapport i Samkost 32018Rapport (Annet vitenskapelig)
    Abstract [sv]

    I detta notat presenteras underlag och beräkningar för delprojektet luftföroreningar som genomförts inom ramen för VTI:s tredje regeringsuppdrag avseende Trafikens Samhällsekonomiska Kostnader (Samkost 3). Vi har i denna studie beräknat marginella externa kostnader för luftföroreningar med den metod som utvecklats och använts inom EU för detta syfte, den så kallade ”Impact Pathway Approach”, med fokus på utsläpp från flyg i svenskt luftrum.

    I den föregående studien om luftföroreningar från sjöfart undersöktes hur detta transportslag bidrar till sekundära föroreningar och vilken betydelse dessa har för befolkningsexponering och påverkan på ekosystemet. Det konstaterades att det är en synnerligen viktig fråga eftersom det är dessa föroreningar som är i fokus när det gäller EU:s luftvårdsarbete. Detta gäller även för flyg där utsläpp som sker på högre höjd sprids och ger påverkan över stora geografiska områden. Flyg har dock också en lokal påverkan vid start och landning. Av denna anledning blev fokus i denna uppföljande studie hur beräkningar kan genomföras för utsläpp som sker på olika höjd.

    För att kunna genomföra dessa beräkningar krävs underlag i form av spridningsmodeller varför detta liksom tidigare upphandlats av SMHI som länge arbetat med att genomföra sådana modelleringar. För flyg har detta inte genomförts i denna omfattning tidigare varför nya indata sammanställts för att kunna genomföra modelleringarna. Det, i kombination med att detta är komplexa beräkningsmodeller som kräver tid, har inneburit behov av avgränsningar. För att få någon information om påverkan från olika typer av flyg har separata beräkningar genomförts för inhemskt flyg, internationellt flyg som startar i Sverige samt överflygningar. Beräkningar har också skett för utsläpp på olika höjd, 0–1 000 meter, 1 000–10 000 meter och utsläpp över 10 000 meter.

  • Hazelius-Berg, Gunnel
    Nordiska museet.
    Stolklädsel från 17401941Inngår i: Fataburen - Nordiska Museet och Skansens Årsbok, Stockholm: Nordiska museets förlag, 1941, s. 220-221Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Nylén, Anna-Maja
    Nordiska museet.
    Spets från 1600-talet1941Inngår i: Fataburen - Nordiska Museet och Skansens Årsbok, Stockholm: Nordiska museets förlag, 1941, s. 217-219Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Lagerquist, Marshall
    Nordiska museet.
    En kopparslagares mästerstycke1941Inngår i: Fataburen - Nordiska Museet och Skansens Årsbok, Stockholm: Nordiska museets förlag, 1941, s. 214-216Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Foss, Stein
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Transplantationskirurgi. Oslo Univ Hosp, Rigshosp, Dept Transplantat Med, Oslo, Norway.
    Nordheim, Espen
    Oslo Univ Hosp, Rigshosp, Dept Transplantat Med, Oslo, Norway;Univ Oslo, Inst Clin Med, Oslo, Norway.
    Sorensen, Dag W.
    Oslo Univ Hosp, Div Emergencies & Crit Care, Oslo, Norway.
    Syversen, Torgunn B.
    Oslo Univ Hosp, Div Emergencies & Crit Care, Oslo, Norway.
    Midtvedt, Karsten
    Oslo Univ Hosp, Rigshosp, Dept Transplantat Med, Oslo, Norway;Univ Oslo, Inst Clin Med, Oslo, Norway.
    Asberg, Anders
    Oslo Univ Hosp, Rigshosp, Dept Transplantat Med, Oslo, Norway;Univ Oslo, Sch Pharm, Oslo, Norway.
    Dahl, Thorleif
    Oslo Univ Hosp, Dept Cardiothorac Surg, Oslo, Norway.
    Bakkan, Per A.
    Oslo Univ Hosp, Rigshosp, Dept Transplantat Med, Oslo, Norway.
    Foss, Aksel E.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Transplantationskirurgi. Oslo Univ Hosp, Rigshosp, Dept Transplantat Med, Oslo, Norway.
    Geiran, Odd R.
    Oslo Univ Hosp, Dept Cardiothorac Surg, Oslo, Norway;Univ Oslo, Inst Clin Med, Oslo, Norway.
    Fiane, Arnt E.
    Oslo Univ Hosp, Dept Cardiothorac Surg, Oslo, Norway;Univ Oslo, Inst Clin Med, Oslo, Norway.
    Line, Pal-Dag
    Oslo Univ Hosp, Rigshosp, Dept Transplantat Med, Oslo, Norway;Univ Oslo, Inst Clin Med, Oslo, Norway.
    First Scandinavian Protocol for Controlled Donation After Circulatory Death Using Normothermic Regional Perfusion2018Inngår i: Transplantation direct, E-ISSN 2373-8731, Vol. 4, nr 7, artikkel-id e366Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background. Donation after circulatory death (DCD) can increase the pool of available organs for transplantation. This pilot study evaluates the implementation of a controlled DCD (cDCD) protocol using normothermic regional perfusion in Norway. Methods. Patients aged 16 to 60 years that are in coma with documented devastating brain injury in need of mechanical ventilation, who would most likely attain cardiac arrest within 60 minutes after extubation, were eligible. With the acceptance from the next of kin and their wish for organ donation, life support was withdrawn and cardiac arrest observed. After a 5-minute no-touch period, extracorporeal membrane oxygenation for post mortem regional normothermic regional perfusion was established. Cerebral and cardiac reperfusion was prevented by an aortic occlusion catheter. Measured glomerular filtration rates 1 year postengraftment were compared between cDCD grafts and age-matched grafts donated after brain death (DBD). Results. Eight cDCD were performed from 2014 to 2015. Circulation ceased median 12 (range, 6-24) minutes after withdrawal of life-sustaining treatment. Fourteen kidneys and 2 livers were retrieved and subsequently transplanted. Functional warm ischemic time was 26 (20-51) minutes. Regional perfusion was applied for 97 minutes (54-106 minutes). Measured glomerular filtration rate 1 year postengraftment was not significantly different between cDCD and donation after brain death organs, 75 (65-76) vs 60 (37-112) mL/min per 1.73 m(2) (P = 0.23). No complications have been observed in the 2 cDCD livers. Conclusion. A protocol for cDCD is successfully established in Norway. Excellent transplant outcomes have encouraged us to continue this work addressing the shortage of organs for transplantation.

  • Lagerquist, Marshall
    Nordiska museet.
    Bestick från Karl XIs tid1941Inngår i: Fataburen - Nordiska Museet och Skansens Årsbok, Stockholm: Nordiska museets förlag, 1941, s. 212-213Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Hazelius-Berg, Gunnel
    Nordiska museet.
    Stickad tröja1941Inngår i: Fataburen - Nordiska Museet och Skansens Årsbok, Stockholm: Nordiska museets förlag, 1941, s. 210-211Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Lagerquist, Marshall
    Nordiska museet.
    En dörr från den yngre Vasatiden1941Inngår i: En dörr från den yngre Vasatiden, Stockholm: Nordiska museets förlag, 1941, s. 207-209Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Hazelius-Berg, Gunnel
    Nordiska museet.
    En riksdrots i gala1941Inngår i: Fataburen - Nordiska Museet och Skansens Årsbok, Stockholm: Nordiska museets förlag, 1941, s. 189-206Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Sundelin, Anders
    et al.
    Blekinge Tekniska Högskola, Fakulteten för datavetenskaper, Institutionen för programvaruteknik.
    Gonzalez-Huerta, Javier
    Blekinge Tekniska Högskola, Fakulteten för datavetenskaper, Institutionen för programvaruteknik.
    Wnuk, Krzysztof
    Blekinge Tekniska Högskola, Fakulteten för datavetenskaper, Institutionen för programvaruteknik.
    Test-Driving FinTech Product Development: An Experience Report2018Inngår i: Conference Proceedings PROFES 2018, Springer, 2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    In this paper, we present experiences from eight years of developing a financial transaction engine, using what can be described as an integration-test-centric software development process.We discuss the product and the relation between three different categories of its software and how the relative weight of these artifacts has varied over the years.In addition to the presentation, some challenges and future research directions are discussed.

  • Bengtsson, Bengt
    Nordiska museet.
    Den Möllenborgska verkstaden på Skansen1941Inngår i: Fataburen - Nordiska Museet och Skansens Årsbok, Stockholm: Nordiska museets förlag, 1941, s. 173-188Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Sturm, Bob
    et al.
    KTH, Skolan för elektroteknik och datavetenskap (EECS), Tal, musik och hörsel, TMH.
    Ben-Tal, Oded
    Kingston University, UK.
    Let’s Have Another Gan Ainm: An experimental album of Irish traditional music and computer-generated tunes2018Rapport (Annet vitenskapelig)
    Abstract [en]

    This technical report details the creation and public release of an album of folk music, most which comes from material generated by computer models trained on transcriptions of traditional music of Ireland and the UK.For each computer-generated tune appearing on the album, we provide below the original version and the alterations made.

  • Engström, Per
    et al.
    Uppsala universitet.
    Forsell, Eskil
    Spotify.
    Hagen, Johannes
    Högskolan i Jönköping, Internationella Handelshögskolan, IHH, Nationalekonomi.
    Stefansson, Arnaldur
    Uppsala universitet.
    Bostadstillägg för pensionärer: ett randomiserat informationsexperiment2018Inngår i: Ekonomisk Debatt, ISSN 0345-2646, Vol. 46, nr 5, s. 29-37Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Många äldre med låga inkomster ansöker inte om bostadstillägg för pensionärer trots att de kan ha rätt till det. En viktig fråga är därför hur man kan få fler berättigade att ansöka. Vi har tillsammans med Pensionsmyndigheten genomfört ett randomiserat informationsexperiment riktat till populationen av potentiellt berättigade pensionärer. Ungefär var tionde pensionär som fick ett brev (behandlingsgruppen) ansökte om bostadstillägg inom fyra månader jämfört med drygt en av hundra som inte fick ett brev (kontrollgruppen). Andelen avslag i behandlingsgruppen var dock något högre.

  • Disputas: 2018-10-10 10:00 Magnélisalen, Kemiska övningslaboratoriet, Stockholm
    Henriksson, Linda
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Structural and functional studies of a novel Botulinum neurotoxin and of MTH12018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    X-ray crystallography visualizes the three dimensional molecular structures of proteins at atomic resolution. Seeing the molecular structure of a biomedically interesting protein enables a higher understanding of its function. The process of producing pure protein from genetic material to generate crystals and determine the molecular structure can be a long and challenging process. My thesis involves structural and functional studies of two different proteins, which are both biomedically interesting and important to learn about. X-ray crystallography is the method which has been used to determine the majority of the protein structures that we know of today and is also the method used in the results presented in my thesis. 

    Today there are no cancer therapies defeating all types of cancers and they do not come without side effects. Battling cancer diseases often include long and painful treatments. Finding an anti-cancer drug targeting phenotypes characteristic of cancer cells is a compelling thought. MutT homolog-1 (MTH1) is an enzyme present in all proliferating cells. The enzyme seems to be crucial for cancer cell survival but not for the viability of normal cells. MTH1 cleans out oxidized and thereby damaged nucleotides from the free nucleotide pool and stops them from being used in DNA synthesis. This process is very important in fast proliferating cancer cells. The hypothesis is to inhibit MTH1 and thereby allow a limitless amount of DNA damage in the cancer cells. This action will eventually kill cancer cells while not affecting normal cells. The molecular structure of MTH1 with (PDB ID: 3ZR0) and without a product bound (PDB ID: 3ZR1) was determined and is presented in my thesis. These two structures aided in the synthesis of inhibitors. 

    Botulinum neurotoxins (BoNTs) are the most potent toxins known. As little as one gram of pure toxin could potentially kill one million people. Due to its potency BoNT is a potential  bioterrorism threat. The toxin is also a very potent drug used clinically to relieve the symptoms of an array of neuromuscular disorders. Most people know this neurotoxin by one of its commercial names: Botox™. Additionally BoNTs are the cause of botulism. BoNTs are neuro-specific enzymes that target neuromuscular signaling, inducing flaccid paralysis and potentially death. It is of importance to learn more about these toxins to enable the development of new countermeasures, vaccines or more efficient neuroparalytic drugs. BoNTs consist of three domains with different functions, all crucial for intoxication. The toxins are fragile and can easily be destroyed by harsh surroundings if not protected by non-toxic non-hemagglutinin (NTNH) proteins. The complex of some BoNT serotypes and their protective NTNH have proven to be pH-dependent. Parts of the intoxication process are not yet clear and their mechanisms are still puzzling researchers. Until recently seven BoNT serotypes were identified. We have now identified and characterized a novel serotype called BoNT/X. The molecular structure of the active domain is presented here (PDB ID: 6F47). The pH-dependent mechanism forming a complex as seen in other serotypes, is confirmed to be present in BoNT/X as well.

  • FitzGerald, L. M.
    et al.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia;Univ Tasmania, Menzies Inst Med Res, Canc Genet & Immunol, Hobart, Tas 7001, Australia.
    Zhao, S.
    NIEHS, Biostat & Computat Biol Branch, Res Triangle Pk, NC 27709 USA.
    Leonardson, A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.
    Geybels, M. S.
    Maastricht Univ, Med Ctr, GROW Sch Oncol & Dev Biol, Dept Epidemiol, NL-6211 LK Maastricht, Netherlands;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.
    Kolb, S.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.
    Lin, D. W.
    Univ Washington, Sch Med, Dept Urol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.
    Wright, J. L.
    Univ Washington, Sch Med, Dept Urol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.
    Eeles, R.
    Royal Marsden Natl Hlth Serv Fdn Trust, London, England;Royal Marsden Natl Hlth Serv Fdn Trust, Sutton SW3 6JJ, Surrey, England;Inst Canc Res, Sutton SM2 5NG, Surrey, England.
    Kote-Jarai, Z.
    Inst Canc Res, Sutton SM2 5NG, Surrey, England.
    Govindasami, K.
    Inst Canc Res, Sutton SM2 5NG, Surrey, England.
    Giles, G. G.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Carlton, Vic 3053, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia.
    Southey, M. C.
    Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic 3010, Australia.
    Schleutker, J.
    Turku Univ Hosp, Dept Med Genet, Tuch Microbiol & Genet, Turku 20520, Finland;Univ Turku, Dept Med Biochem & Genet, Inst Biomed, Turku 20014, Finland.
    Tammela, T. L.
    Tampere Univ Hosp, Dept Urol, Tampere 33521, Finland;Univ Tampere, Prostate Canc Res Ctr, Sch Med, Tampere 33100, Finland.
    Sipeky, C.
    Univ Turku, Dept Med Biochem & Genet, Inst Biomed, Turku 20014, Finland.
    Penney, K. L.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;Brigham & Womens Hosp, Dept Med, Charming Div Network Med, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA.
    Stampfer, M. J.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;Brigham & Womens Hosp, Dept Med, Charming Div Network Med, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
    Gronberg, H.
    Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden.
    Wiklund, F.
    Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden.
    Stattin, Pär
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Urologkirurgi. Umea Univ, Dept Surg & Perioperat Sci, S-90187 Umea, Sweden.
    Hugosson, J.
    Univ Goteborgs, Inst Clin Sci, Dept Urol, S-40530 Goteborgs, Sweden.
    Karyadi, D. M.
    NHGRI, NIH, Bethesda, MD 20854 USA.
    Ostrander, E. A.
    NHGRI, NIH, Bethesda, MD 20854 USA.
    Feng, Z.
    MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA.
    Stanford, J. L.
    Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.
    Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases2018Inngår i: Prostate Cancer and Prostatic Diseases, ISSN 1365-7852, E-ISSN 1476-5608, Vol. 21, nr 2, s. 228-237Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several germline variants have been associated with PCa-specific mortality (PCSM), but further replication evidence is needed.

    Methods: Twenty-two previously identified PCSM-associated genetic variants were genotyped in seven PCa cohorts (12,082 patients; 1544 PCa deaths). For each cohort, Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for risk of PCSM associated with each variant. Data were then combined using a meta-analysis approach.

    Results Fifteen SNPs were associated with PCSM in at least one of the seven cohorts. In the meta-analysis, after adjustment for clinicopathological factors, variants in the MGMT (rs2308327; HR 0.90; p-value = 3.5 x 10(-2)) and IL4 (rs2070874; HR 1.22; p-value = 1.1 x 10(-3)) genes were confirmed to be associated with risk of PCSM. In analyses limited to men diagnosed with local or regional stage disease, a variant in AKT1, rs2494750, was also confirmed to be associated with PCSM risk (HR 0.81; p-value = 3.6 x 10(-2)).

    Conclusions: This meta-analysis confirms the association of three genetic variants with risk of PCSM, providing further evidence that genetic background plays a role in PCa-specific survival. While these variants alone are not sufficient as prognostic biomarkers, these results may provide insights into the biological pathways modulating tumour aggressiveness.

  • Weickert, Martin O.
    et al.
    Univ Hosp Coventry, ENETS Ctr Excellence, ARDEN NET Ctr, Coventry CV2 2DX, W Midlands, England;Warwickshire Natl Hlth Serv Trust, Coventry CV2 2DX, W Midlands, England.
    Kaltsas, Gregory
    Univ Hosp Coventry, ENETS Ctr Excellence, ARDEN NET Ctr, Coventry CV2 2DX, W Midlands, England;Warwickshire Natl Hlth Serv Trust, Coventry CV2 2DX, W Midlands, England.
    Hörsch, Dieter
    Zent Klin Bad Berka, Bad Berka, Germany.
    Lapuerta, Pablo
    Lexicon Pharmaceut Inc, The Woodlands, TX USA.
    Pavel, Marianne
    Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany;Charite, Berlin, Germany.
    Valle, Juan W.
    Univ Manchester, Christie Natl Hlth Serv Fdn Trust, Manchester, Lancs, England.
    Caplin, Martyn E.
    Royal Free Hosp, European Neuroendocrine Tumor Soc Ctr Excellence, Neuroendocrine Tumour Unit, London, England.
    Bergsland, Emily
    Univ Calif San Francisco, San Francisco, CA 94143 USA.
    Kunz, Pamela L.
    Stanford Univ, Sch Med, Stanford, CA USA.
    Anthony, Lowell B.
    Univ Kentucky, Lexington, KY USA.
    Grande, Enrique
    MD Anderson Int Canc Ctr, Madrid, Spain.
    Öberg, Kjell
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Endokrin tumörbiologi.
    Welin, Staffan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Onkologisk endokrinologi.
    Lombard-Bohas, Catherine
    Hosp Civils Lyon, Hop Edouard Herriot, Lyon, France.
    Ramage, John K.
    Kings Coll Hosp London, Kings Hlth Partners European Neuroendocrine Tumor, London, England.
    Kittur, Ashwin
    Lexicon Pharmaceut Inc, The Woodlands, TX USA.
    Yang, Qi M.
    Lexicon Pharmaceut Inc, The Woodlands, TX USA.
    Kulke, Matthew H.
    Dana Farber Canc Inst, Boston, MA 02115 USA.
    Changes in Weight Associated With Telotristat Ethyl in the Treatment of Carcinoid Syndrome2018Inngår i: Clinical Therapeutics, ISSN 0149-2918, E-ISSN 1879-114X, Vol. 40, nr 6, s. 952-962Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose: In the placebo-controlled Phase III TELE-STAR (Telotristat Etiprate for Somatostatin Analogue Not Adequately Controlled Carcinoid Syndrome) trial, the oral tryptophan hydroxylase inhibitor telotristat ethyl significantly reduced bowel movement (BM) frequency during a 12-week, double-blind treatment period in 135 patients with metastatic neuroendocrine tumors with carcinoid syndrome and >= 4 BMs per day. Patients (mean [SD] age, 63.5 [8.9] years; mean [SD] body mass index, 24.9 [4.9] kg/m(2)) received placebo, telotristat ethyl 250 mg, or telotristat ethyl 500 mg 3 times per day (TID) in addition to somatostatin analogue therapy. Weight loss is associated with uncontrolled carcinoid syndrome and may be associated with reduced survival.

    Methods: Assessment of the occurrence of weight change >= 3% at week 12 was prespecified in the statistical analysis plan.

    Findings: In 120 patients with weight data available, weight gain >= 3% was observed in 2 of 39 patients (5.1%) taking placebo [1.1), 7 of 41 (17.1%) taking telotristat ethyl 250 mg TID, and 13 of 40 (32.5%) taking telotristat ethyl 500 mg TID (P = 0.0017) at week 12. Weight loss >= 3% was observed in 5 of 39 patients (12.8%) taking placebo TID, 4 of 41 (9.8%) taking telotristat ethyl 250 mg TID, and 6 of 40 (15.0%) taking telotristat ethyl 500 mg TID (P = 0.77). Biochemical and metabolic parameters of serum albumin and cholesterol significantly increased (P = 0.02 and P = 0.001, respectively) in patients gaining weight and decreased in patients who lost weight, suggesting an improvement in overall nutritional status.

  • Jonsson, Stefan ()
    Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, REMESO - Institutet för forskning om migration, etnicitet och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Om Anna Ådahls Massor2018Kunstnerisk output (Ogranskad)
    Abstract [en]

    Anna Ådahl 2018 av Stefan Jonsson (ENG) 180415 rev SJ.docPage 1of 5Stefan JonssonOnAnna Ådahl’s CrowdsFew things areasbewitchingas the sight of large crowds in motion. Consider the flock of swallows, tens of thousands of birds in perfect coordination,forminga dancing cloud.Considerthe opening of the Olympic Games, a military paradein China or the crowdmaking its way acrossSergel’s torg in Stockholm during rush hour. Look at the colony of ants, the start of the long distance cross-country ski raceVasaloppet, a herd of cattle or the procession of demonstratorsthat stretches for miles in front of and behind you. Anna Ådahl often takes such perspectives. She entersthe metroand seeks a viewpoint with an overview. Then she resolutely places herself or her stand-in in the flow and creates a dam....

  • Elm, Patrik
    et al.
    Linnéuniversitetet, Fakulteten för teknik (FTK), Institutionen för informatik (IK).
    Iqbal, Sarfraz
    Linnéuniversitetet, Fakulteten för teknik (FTK), Institutionen för informatik (IK).
    Mirijamdotter, Anita
    Linnéuniversitetet, Fakulteten för teknik (FTK), Institutionen för informatik (IK).
    Exploring threshold concept when teaching Systems Thinking and Soft Systems Methodology2018Konferansepaper (Fagfellevurdert)
    Abstract [en]

    It has been argued that the threshold concepts of a discipline are the gateways to a deeper understanding of disciplinary knowledge. These are also keys to improving student learning outcomes and progressive learning. Research has been done on systems as a threshold concept for understanding other disciplinary issues, like sustainability. However, we explore the threshold concepts of understanding systems itself, that is, in this case the disciplinary framework of systems thinking and Soft Systems Methodology. The term threshold concept is stated as having emerged from the UK project Enhancing Teaching and Learning Environments in Undergraduate Courses. It is argued to be a means leading to a transformed way of understanding or learning. Five key characteristics of threshold concepts have been identified in previous research. These are troublesome knowledge, transformation, irreversibility, integration, and boundedness. Later on, reconstitution, discourse and liminality were added.

    We have explored threshold concepts for teaching systems thinking and Soft Systems Methodology in a mixed knowledge environment, including students from different disciplines, in a developing country. The students were presented with an issue related to their everyday life as university students and with the aim of applying systems thinking ideas and techniques for the betterment of their university and, in the long run, their society. They were also asked to write a reflection paper related to the learning objectives of the course and on what they have learnt about Soft Systems Methodology (theory) and when applied to the specific case. We report on which pertinent threshold concepts we have identified, both of our own experience as teachers and of the students’ reflection papers.

  • Sörlin, Sverker
    Filosofi och historia, KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Filosofi och teknikhistoria, Historiska studier av teknik, vetenskap och miljö.
    När avgrunden öppnar sig: Review of: Malena Ernman & Svante Thunberg, Scener ur hjärtat (Stockholm: Polaris, 2018)2018Inngår i: Dagens Nyheter, nr 2018-09-15, artikkel-id DN Kultur p. 7Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • Lindahl, Jonas
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Sociologiska institutionen.
    Colliander, Cristian
    Umeå universitet, Umeå universitetsbibliotek (UB). Umeå universitet, Samhällsvetenskapliga fakulteten, Sociologiska institutionen.
    Danell, Rickard
    Umeå universitet, Samhällsvetenskapliga fakulteten, Sociologiska institutionen.
    In search of future excellence: The information value of bibliometric indicators in predicting doctoral students' future research performance2018Inngår i: Proceedings of the 23rd International Conference on Science and Technology Indicators / [ed] Rodrigo Costas, Thomas Franssen, Alfredo Yegros-Yegros, Leiden, 2018, s. 448-459Konferansepaper (Fagfellevurdert)
    Abstract [en]

    The purpose of this study was to investigate the predictive value of using bibliometric indicators of scientific performance during doctoral studies to predict who will attain future excellence in a local organizational context. The data consisted of 479 Swedish doctoral students employed at a single Swedish university that completed their studies between 2003 and 2009. We used a probit regression model to estimate the probability for future excellence, operationalized with a citation based indicator. The model included five predictors: publication volume, excellence during doctoral studies, collaboration, age at thesis completion, and gender. Our main results were: (1) an interaction between publication volume and attaining excellence during doctoral studies, indicating that the effect of publication volume on the probability of attaining future excellence is much stronger for the group of excellent doctoral students than for the group of non-excellent students; (2) collaboration and age are significant predictors of future excellence; (3) examining potential gender bias the results were somewhat inconclusive. Male doctoral students had a higher probability of attaining future excellence. However, the effect was not significant (p>0.05). Our main conclusion is that bibliometric indicators has some predictive validity for post-doctoral performance in a local organizational context and that a combination of quantity and quality in doctoral students’ performance generated the highest probabilities of future excellence.

  • Abdalmoaty, Mohamed R.
    et al.
    KTH, Skolan för elektroteknik och datavetenskap (EECS), Reglerteknik.
    Hjalmarsson, Håkan
    KTH, Skolan för elektroteknik och datavetenskap (EECS), Reglerteknik.
    Linear Prediction Error Methods for Stochastic Nonlinear Models2018Inngår i: Automatica, ISSN 0005-1098, E-ISSN 1873-2836Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The estimation problem for stochastic parametric nonlinear dynamical models is recognized to be challenging. The main difficulty is the intractability of the likelihood function and the optimal one-step ahead predictor. In this paper, we present relatively simple prediction error methods based on non-stationary predictors that are linear in the outputs. They can be seen as extensions of the linear identification methods for the case where the hypothesized model is stochastic and nonlinear. The resulting estimators are defined by analytically tractable objective functions in several common cases. It is shown that, under certain identifiability and standard regularity conditions, the estimators are consistent and asymptotically normal. We discuss the relationship between the suggested estimators and those based on second-order equivalent models as well as the maximum likelihood method. The paper is concluded with a numerical simulation example as well as a real-data benchmark problem.

  • Josephson, Peter
    Södertörns högskola, Institutionen för historia och samtidsstudier, Idéhistoria.
    "Those who cannot rememeber the past...": Utkast till en historielöshetens historia2018Inngår i: Arche - tidskrift för psykoanalys, humaniora och arkitektur, ISSN 2000-7817, nr 64-65, s. 138-145Artikkel i tidsskrift (Annet vitenskapelig)
  • Wallner, Bengt
    et al.
    Umea Univ Hosp, Dept Surg & Perioperat Sci, Surg, SE-90185 Umea, Sweden.
    Bjoer, Ove
    Umea Univ, Div Oncol, Dept Radiat Sci, Umea, Sweden.
    Andreasson, Anna
    Macquarie Univ, Dept Psychol, N Ryde, NSW, Australia;Karolinska Inst, Div Family Med & Primary Care, Huddinge, Sweden;Stockholm Univ, Stress Res Inst, Stockholm, Sweden.
    Hellström, Per M
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Gastroenterologi/hepatologi.
    Forsberg, Anna M.
    Karolinska Inst, Dept Med Solna, Stockholm, Sweden.
    Talley, Nicholas J.
    Karolinska Inst, Div Family Med & Primary Care, Huddinge, Sweden;Univ Newcastle, Fac Hlth & Med, Newcastle, NSW, Australia.
    Agreus, Lars
    Karolinska Inst, Div Family Med & Primary Care, Huddinge, Sweden.
    Identifying clinically relevant sliding hiatal hernias: a population-based endoscopy study2018Inngår i: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 53, nr 6, s. 657-660Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: The clinical relevance of small to moderate sliding hiatal hernias is controversial. The aims of the present study were to (1) investigate which symptoms are associated with sliding hiatal hernias and (2) define the length of a sliding hiatal hernia at which gastrointestinal symptoms occur.Methods: A study population representative of the general Swedish population answered a questionnaire regarding gastrointestinal symptoms and was investigated with an upper endoscopy. The length of any sliding hiatal hernia was measured.Results: Only reflux-related symptoms were associated with length of the hiatal hernia (acid regurgitation OR 1.46, CI 1.19-1.79, heartburn OR 1.27, CI 1.05-1.54), and the association did not become significant until an axial hiatal hernia length of 2cm.Conclusions: Only reflux symptoms could be attributed to sliding hiatal hernias. Hiatal hernias less than 2cm should be considered clinically insignificant.

  • Doerstling, Steven
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås.
    Hedberg, Pär
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Västmanland Cty Hosp, Dept Clin Physiol, Västerås, Sweden.
    Öhrvik, John
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås.
    Leppert, Jerzy
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås.
    Henriksen, Egil
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Västmanland Cty Hosp, Dept Clin Physiol, Västerås, Sweden.
    Growth differentiation factor 15 in a community-based sample: age-dependent reference limits and prognostic impact2018Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, nr 2, s. 86-93Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Despite the growing body of evidence on growth differentiation factor 15 (GDF-15) reference values for patients with existing cardiovascular disease, limited investigation has been dedicated to characterizing the distribution and prognostic impact of GDF-15 in predominantly healthy populations. Furthermore, current cutoff values for GDF-15 fail to account for the well-documented age-dependence of circulating GDF-15. Methods: From 810 community-dwelling older adults, we selected a group of apparently healthy participants (n = 268). From this sample, circulating GDF-15 was modeled using the generalized additive models for location scale and shape (GAMLSS) to develop age-dependent centile values. Unadjusted and adjusted Cox proportional hazards models were used to assess the association between the derived GDF-15 reference values (expressed as centiles) and all-cause mortality. Results: Smoothed centile curves showed increasing GDF-15 with age in the apparently healthy participants. An approximately three-fold difference was observed between the 95th and 5th GDF-15 centiles across ages. In a median 8.0 years of follow-up, 97 all-cause deaths were observed in 806 participants with eligible values. In unadjusted Cox regression analyses, the hazard ratio (95% CI) for all-cause mortality per 25-unit increase in GDF-15 centile was 1.80 (1.48-2.20) and dichotomized at the 95th centile, >= 95th versus <95th, was 3.04 (1.99-4.65). Age-dependent GDF-15 centiles remained a significant predictor of all-cause mortality in all subsequent adjusted models. Conclusions: Age-dependent GDF-15 centile values developed from a population of apparently healthy older adults are independently predictive of all-cause mortality. Therefore, GDF-15 reference values could be a useful tool for risk-stratification in a clinical setting.

  • Karamanidou, Lena
    et al.
    Glasgow Caledonian University.
    Kasparek, Bernd
    Göttingen University.
    Border Management and Migration Control in the European Union2018Rapport (Annet vitenskapelig)
    Abstract [en]

    This report is the first deliverable of Work Package (WP2) Border and Migration Controls of the Horizon 2020 Project RESPOND -- Multilevel Governance of Mass Migration in Europe and Beyond. RESPOND explores the multilevel governance of migration in countries of origin, transit and migration, focusing on the Eastern Mediterranean route. WP2 addresses border management and migration control, including European Union (EU) and domestic legal regimes, policy developments since 2011, the implementation of border management and migration control policies by EU member states and third countries, and how refugees and migrants experience and respond to the EU border management regime. The aim of the report is to provide an overview of the current EU border management and migration control regime in order to contextualise further research on domestic regimes and their implementation. It outlines the key components of the European Union framework on border management and migration controls. It also presents an overview of historical developments, an analysis of discursive aspects of border and migration control on the level of Union institutions between 2011 and 2017, as well as a detailed description of control measures in the different layers of the European Union external border. We use the term border management to refer to the EU’s ensemble of legislation, policies, implementation practices, institutions, and actors that are concerned with defining, conceptualising, and policing of the external border of the member states of the European Union. We use the term migration control to capture modes of control that might fall outside the scope of border management, especially as defined by the 2016 European Border and Coast Guard Directive. We elaborate on these definitional issues in Concepts and Definitions section. We then move on to a detailed analysis of these policies and their legal codification and key legislative and policy developments since 2011. We conclude the report with a discussion of the complexities involved in researching this intersection of various legal frameworks, policy fields and implementation challenges in connection to the larger process of Europeanisation.

  • Wide, Leif
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk kemi.
    Eriksson, Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk kemi.
    Low-glycosylated forms of both FSH and LH play major roles in the natural ovarian stimulation2018Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, nr 2, s. 100-108Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The natural ovarian stimulation is mediated by four gonadotrophin glycoforms: FSHtri with three, FSHtetra with four, LHdi with two, and LHtri with three N-glycans. The aim of the study was to determine the serum concentrations of the four glycoforms and their contents of anionic monosaccharides (AMS), i.e. sialic acid (SA) and sulfonated N-acetylgalactosamine (SU) residues throughout the menstrual cycle. Methods: Serum samples were collected from 78 healthy women with regular menstrual cycles. The serum glycoform molecules were identified by their distributions at electrophoreses. Analyses were also performed after removal of terminal SA. The hormones were measured with time-resolved sandwich fluoroimlooimm u noassays. Results: The concentration profiles of the four glycoforms were markedly different. FSHtri, which had a 3-fold higher biopotency than FSHtetra, had peak levels on cycle day 5 and at midcycle and nadirs on cycle days 9 and 21-23. FSHtetra had a raised level on cycle days 5-12, followed by a decrease. LHdi and LHtri had similar patterns, but the peak/nadir ratio was much more pronounced for LHdi than for LHtri, 18 versus 4. The numbers of SA residues per molecule were at a maximum around midcycle when the corresponding numbers of SU were at a minimum. The SU/SA ratio was at a minimum on cycle day 12. Conclusion: The results indicate that the LHdi and the FSHtri molecules play major roles in the natural ovarian stimulation. The SU/SA ratios per molecule favoured a prolonged circulatory half-life of all glycoforms at the midcycle phase. The observations may lead to more successful inductions of ovulation in anovulatory women.

  • Federico, Veronica
    et al.
    University of Florence.
    Fero, Ginevra CerrinaUniversity of Florence.
    Migration Governance – Collection of Country Reports: Legal and Policy Framework2018Collection/Antologi (Annet vitenskapelig)
    Abstract [en]

    The present collection of country reports represents the collective work of the following RESPOND national teams: Uppsala Universitet (Swedish report), the Glasgow Caledonian University (Hungarian report), Georg-August Universitat Gottigenstiftung Offentlichen Rechts (German report), University of Cambridge (British report), Svenska Forkningsinstitute i Istanbul (Turkish report), Università di Firenze (Italian report and European Union report), Panepistimio Aigaiou (Greek report), Österreichische Akademie der Wissenschafte (Austrian report), Uniwersytet Warszawski (Polish report), Lebanon Support (Lebanese report), Hammurabi Human Rights Organization (Iraqi report). The activities of this Work Package (WP1) have been coordinated by the University of Florence. We are indebted to all the authors for the competence and enthusiasm with which they fulfilled their tasks and for their collaborative approach.

    Each report underwent a double review process: the review by a national expert appointed by national teams, and the review by the work package leader. We are grateful to all national experts that collaborated enhancing the quality of RESPOND research.

  • Ekstrand Ragnar, Maria
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Obstetrisk och reproduktiv hälsoforskning.
    Hultstrand, Jenny Niemeyer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Klinisk obstetrik.
    Tydén, Tanja
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Obstetrisk och reproduktiv hälsoforskning.
    Larsson, Margareta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Obstetrisk och reproduktiv hälsoforskning.
    Development of an evidence-based website on Preconception health2018Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, nr 2, s. 116-122Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction: Many women and men lack knowledge about fertility, including timing of the fertile window, age-related decline, and lifestyle factors that may impair fertility. The Internet has become an important source of information, but evidence-based information on fertility and reproduction in Swedish on the Internet is limited. The present study aimed to develop and evaluate an evidence-based fertility awareness website, 'reproduktivlivsplan.se', to increase awareness of fertility and provide guidance for improved preconception health and care among individuals and healthcare providers. Methods: The website's content, design, and layout were evaluated qualitatively among a total of 20 nursing students. An expert group of researchers also provided feedback on the content. Finally, healthcare providers (n = 24) answered a questionnaire covering attitudes and views on the Reproductive Life Plan website as a tool for counselling. Results: The developing process resulted in a mobile-friendly website, 'reproduktivlivsplan.se' (in English: Reproductive Life Plan). The website, including the content and layout, was positively evaluated by most participants and was amended according to suggested improvements. Uppsala University was found to be a trustworthy source. Conclusion: The evidence-based website 'reproduktivlivsplan.se' was well received among users and healthcare providers and may provide guidance for improved preconception health and care if it becomes well known and frequently used.

  • Hirst, Catherine
    et al.
    University of Cambridge.
    Atto, Naures
    University of Cambridge.
    United Kingdom - Country Report: Legal and Policy Framework of Migration Governance2018Rapport (Annet vitenskapelig)
    Abstract [en]

    This report explores the legal and policy framework of migration governance in the United Kingdom (UK). It shows that migration governance is complicated, reactive, and that the needs of immigrants, refugees and asylum seekers have been eroded at the expense of border control overtime. The constitutional organisation of the state has contributed to these features of immigration policy. Evidence of the complexity, reactivity and restrictiveness of migration governance is found in the UK’s legislative framework, the legal status of foreigners, the reception system and post-refugee crisis reforms. Constitutionally there are three tiers of government in the UK – the central UK Government, the devolved governments of Northern Ireland, Scotland and Wales, and local authorities. The rights of asylum seekers are in a more precarious position than in other countries for two reasons. First, there is no specific right to asylum enshrined in the UK’s uncodified constitution, although the Human Rights Act 1998 plays a significant role in protecting asylum seeker rights. Second, the UK has no entrenched provisions in its constitution, meaning that legislation such as the Human Rights Act 1998 could be amended or replaced simply via an act of parliament. Evidence of the complexity, reactivity and restrictive nature of migration governance can be found in the evolution of legislation. With some notable exceptions, the evolution of primary legislation on immigration and asylum has been regressive, with successive restrictions on appeal rights, social benefits and the criminalization of irregular migrants. Legislation has been introduced to circumvent more progressive court decisions and has at times been rushed through without adequate consultation. Legislation has also tended to be reactive, with each wave of immigration throughout the 20th century being met with a legislative backlash.Routes to live in the UK are incredibly complex, with over 16 different types of work visa, which are being amended, removed and replaced all the time. The reception system for asylum seekers provides another example of the complexity and regressive nature of immigration governance, which fails to meet asylum seekers’ needs. Only destitute and unaccompanied asylum-seeking children have access to the reception system. The weekly allowance given to destitute asylum seekers is barely enough to make ends meet, while reception centre accommodation is not sensitive to the needs of vulnerable asylum seekers.Since the outbreak of the Syrian war, the Government has set up the Syrian Vulnerable Person Resettlement Scheme (VPRS), the Vulnerable Children Resettlement Scheme and children relocated under the ‘Dubs Amendment’. Advocates have been particularly critical of the implementation of the ‘Dubs Amendment’. The current immigration landscape notwithstanding, Brexit has generated significant ambiguity as to the future of UK migration governance. However, there are significant components of UK migration governance that will remain unaffected – the UK will still need to meet its obligations under the Convention Relating to the Status of Refugees 1951 (Refugee Convention) and the European Convention on Human Rights (ECHR), while Brexit will not directly affect the UK’s export of border controls to France2 (Gauci, 2017, p.3). The methodological approach of the report has been to rely on secondary research. Where possible, government documents, policies, legislation and publications have been used in order to gather information about the policy and legal environment directly from the source. This has been supplemented by third sector research reports, text books, academic journal articles, media articles and other public commentary.

  • Errando-Herranz, Carlos
    et al.
    KTH, Skolan för elektro- och systemteknik (EES), Mikro- och nanosystemteknik.
    Le Thomas, Nicolas
    Gylfason, Kristinn B.
    KTH, Skolan för elektro- och systemteknik (EES), Mikro- och nanosystemteknik.
    Low-power optical beam steering by microelectromechanical waveguide gratingsManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Optical beam steering is key for optical communications, laser mapping (LIDAR), and medical imaging. For these applications, integrated photonicsis an enabling technology that can provide miniaturized, lighter, lower cost, and more power efficient systems. However, common integrated photonic devices are too power demanding. Here, we experimentally demonstrate, for the first time, beam steering by microelectromechanical (MEMS)actuation of a suspended silicon photonic waveguide grating. Our device shows up to 5.6° beamsteering with 20 V actuation and a power consumption below the μW level, i.e. more than 5 orders of magnitude lower power consumption than previous thermo-optic tuning methods. The novel combination of MEMS with integrated photonics presented in this work lays ground for the next generation of power-efficient optical beam steering systems.

  • Çetin, Elif
    et al.
    Swedish Research Institute Istanbul.
    Öztürk, Neva Ö.
    Swedish Research Institute Istanbul.
    Gökalp Aras, N. Ela
    Swedish Research Institute Istanbul.
    Şahin Mencütek, Zeynep
    Swedish Research Institute Istanbul.
    Turkey – Country Report: Legal and Policy Framework of Migration Governance2018Rapport (Annet vitenskapelig)
    Abstract [en]

    This country report focuses on developments that took place during the period of 2011-2017 in the field of migration in Turkey. Traditionally a country of emigration, starting from the early 1990s, it has also become an important country of immigration, asylum and transit. Most recently, the increasing pressure of the refugee challenge, particularly given the high number of arrivals from Syria, has put the country once again under international spotlights. This report provides relevant migration statistics that are available as open source data. It briefly reviews the socio-economic, political and cultural characteristic of the country as well as its brief migration history. The report also delves into a detailed analysis of the constitutional, legal and institutional framework of Turkey’s national migration management system, which has gone through significant transition in the last few years. The report points out that due to Turkey’s geographical limitation to the 1951 Geneva Convention Relating to the Status of Refugees (1951 Convention), and its associated 1967 Protocol; Turkey does not grant refugee status to people fleeing from conflicts and persecution in non-European countries. But it does provide ‘conditional refugee status’ along with ‘refugee’ and ‘subsidiary’ protection. The report reveals a key duality regarding European and non-European asylum seekers to be an important characteristic of Turkey’s asylum system. The first group can obtain ‘refugee’ status’; while the second group can only obtain ‘conditional refugee status’. However, regardless of their nationality, due to the Syrian mass migration, Syrian refugees1 are given another international protection status, which is called ‘temporary protection’. The report concludes by highlighting that part of Turkey’s recent migration policy efforts are tied to encouragement coming from the EU for Turkey to improve conditions regarding access to the asylum process and status determination as well as enhancement of its facilities forasylum-seekers’ protection. Although these developments bring Turkey closer to satisfying the EU demands on migration and asylum policy, Turkey is still expected to abolish the geographical limitation of the 1951 Convention to create a full-fledged asylum system and to solve remaining implementation problems. Ensuring equal and fair access to asylum procedures and facilitating the full access of asylum-seekers to legal aid remain priorities still to be achieved.

  • Karlsohn, Thomas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för idé- och lärdomshistoria.
    Digital Technology and Rhetoric in Swedish Educational History2018Rapport (Annet vitenskapelig)
  • Shakra, Mudar
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen, Religionsbeteendevetenskap, Religionspsykologi.
    Wirman, Jenni
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Centrum för forskning om religion och samhälle (CRS).
    Szalanska, Justyna
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen.
    Sweden – Country Report: Legal and Policy Framework of Migration Governance2018Rapport (Annet vitenskapelig)
    Abstract [en]

    The report aims to present the legal and policy framework of migration in Sweden in a period between 2011 and 2017. In the mentioned time Sweden witnessed a U-turn in migration governance linked with an unprecedented influx of asylum seekers in 2015 when more than 160,000 asylum applications were submitted, and introduction of a new temporary law on asylum in 2016. Since 2016, Sweden has been reshaping its image of a country open to refugees through new restrictive legislative measures which are a response not only to the mass migration, but also to lack of solidarity within the European Union on the matter of refugees acceptance. After the World War II Sweden, due to its level of economic development, the state model (welfare state) and the political system (established democracy), has become a desired destination for migrants and refugees. The constitutional entrenchment of the asylum principle in Sweden is derived from its international and European commitments, namely the European Convention for the Protection of Human Rights and Fundamental Freedoms, the 1951 Geneva Convention for Refugees and other international human rights instruments. The migration governance system in Sweden consists of several legislative acts dealing with different aspects of migration and asylum, such as asylum judicial procedures, reception, detention, health case, allowance, citizenship and boarders control. Considering migration management structure, the responsibility to enact and coordinate the various judicial, legislative, administrative and financial aspects related to migration and asylum rests in hands of the Ministry of Justice and is performed through its three divisions: Division for Migration Law (L7), Division for Migration and Asylum Policy (EMA) and Division for Management of Migration Affairs (SIM). After the record number of migrants coming to Sweden in 2015 and, as a result, the highest number of application for residence permit in the same year, the government introduced in 2016 restrictions to granting residence permit. Some of the main changes were to take away the possibility of permanent residency permit and tightened the family reunification possibility in order to reach the minimum level in comparison to an international and European level or to what the family reunification process in Sweden used to be before July 2016.

    In the section ‘Legal Status of Foreigners’ the report presents the legal process of granting an asylum in Sweden, including requirements for submitting an application, steps of the procedures of application, registration and reception, identification process of an asylum seeker, rights to information and legal counselling, and other rights given to an asylum seeker such as access to housing, labour market, professional trainings and health care system.