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  • Kalepu, Jagadeesh
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Organisk kemi.
    Gandeepan, Parthasarathy
    Georg August Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany.
    Ackermann, Lutz
    Georg August Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany.
    Pilarski, Lukasz T.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Organisk kemi.
    C4-H indole functionalisation: precedent and prospects2018Inngår i: Chemical Science, ISSN 2041-6520, E-ISSN 2041-6539, Vol. 9, nr 18, s. 4203-4216Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    C4-decorated indoles feature in a plethora of bioactive and functional compounds of importance to natural product synthesis, material sciences, as well as crop protection and pharmaceutical industries. Traditionally, their syntheses largely involved harsh stoichiometric metalations and radical reactions. However, transition metal catalysed C-H activation has recently evolved into a powerful strategy for the late-stage diversification of indoles at the C4-H position. Modern photoredox, enzymatic and precious transition metal catalysis represent the key stimuli for developing challenging C-C and C-Het bond forming transformations under mild reaction conditions. Herein, we discuss the evolution and application of these methods for the step-economical transformations of otherwise inert C4-H bonds up to December 2017.

  • Silva, Willian T. A. F.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Evolutionsbiologi.
    Methylation dynamics during the maternal-to-zygotic genome transition in dioecious species.2018Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 7, artikkel-id e0200028Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The starting point of a new generation in sexually reproducing species is fertilization. In many species, fertilization is followed by cell divisions controlled primarily by maternal transcripts, with little to no zygotic transcription. The activation of the zygotic genome (ZGA) is part of a process called maternal-to-zygotic transition (MZT), during which transcripts from the zygotic genome take control of development, setting the conditions for cellular specialization. While we know that epigenetic processes (e.g. methylation) are involved in the MZT, their roles and interplay in the transition are largely unknown. I developed a model and used simulations to elucidate the interaction between possible epigenetic processes, namely methylation processes, involved in the MZT. The model focuses on the dynamics of global methylation levels and how these interact with factors such as a parental repressor and the nucleocytoplasmic ratio to trigger the ZGA, followed by development from fertilization to adulthood. In addition, I included transgenerational effects transmitted to the zygote from both parents through their gametes to show that these may set the stage for plastic developmental processes. I demonstrate that the rates of maintenance methylation and demethylation, which are important for the achievement of the final methylation levels of an individual, exhibit a certain level of flexibility in terms of parameter values. I find that high final methylation levels require more restricted combinations of parameter values. The model is discussed in the context of the current empirical knowledge and provide suggestions for directions of future empirical and theoretical studies.

  • Mashad Nemati, Hassan
    et al.
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), CAISR Centrum för tillämpade intelligenta system (IS-lab).
    Laso, A.
    Department of Electrical and Energy Engineering, University of Cantabria, Santander, Spain.
    Manana, M.
    Department of Electrical and Energy Engineering, University of Cantabria, Santander, Spain.
    Pinheiro Sant'Anna, Anita
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), CAISR Centrum för tillämpade intelligenta system (IS-lab).
    Nowaczyk, Sławomir
    Högskolan i Halmstad, Akademin för informationsteknologi, Halmstad Embedded and Intelligent Systems Research (EIS), CAISR Centrum för tillämpade intelligenta system (IS-lab).
    Stream Data Cleaning for Dynamic Line Rating Application2018Inngår i: Energies, ISSN 1996-1073, E-ISSN 1996-1073, Vol. 11, nr 8, artikkel-id 2007Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The maximum current that an overhead transmission line can continuously carry depends on external weather conditions, most commonly obtained from real-time streaming weather sensors. The accuracy of the sensor data is very important in order to avoid problems such as overheating. Furthermore, faulty sensor readings may cause operators to limit or even stop the energy production from renewable sources in radial networks. This paper presents a method for detecting and replacing sequences of consecutive faulty data originating from streaming weather sensors. The method is based on a combination of (a) a set of constraints obtained from derivatives in consecutive data, and (b) association rules that are automatically generated from historical data. In smart grids, a large amount of historical data from different weather stations are available but rarely used. In this work, we show that mining and analyzing this historical data provides valuable information that can be used for detecting and replacing faulty sensor readings. We compare the result of the proposed method against the exponentially weighted moving average and vector autoregression models. Experiments on data sets with real and synthetic errors demonstrate the good performance of the proposed method for monitoring weather sensors.

  • Satari, B.
    et al.
    Swedish Centre for Resource Recovery, University of Borås.
    Karimi, K.
    Department of Chemical Engineering, Isfahan University of Technology.
    Taherzadeh, Mohammad J
    Högskolan i Borås, Akademin för textil, teknik och ekonomi.
    Zamani, Akram
    Högskolan i Borås, Akademin för textil, teknik och ekonomi.
    Co-production of fungal biomass derived constituents and ethanol from citruswastes free sugars without auxiliary nutrients in airlift bioreactor2016Inngår i: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 17, nr 3Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The potential of two zygomycetes fungi, Mucor indicus and Rhizopus oryzae, in assimilating citrus waste free sugars (CWFS) and producing fungal chitosan, oil, and protein as well as ethanol was investigated. Extraction of free sugars from citrus waste can reduce its environmental impact by decreasing the possibility of wild microorganisms growth and formation of bad odors, a typical problem facing the citrus industries. A total sugar concentration of 25.1 g/L was obtained by water extraction of citrus waste at room temperature, used for fungal cultivation in shake flasks and airlift bioreactor with no additional nutrients. In shake flasks cultivations, the fungi were only able to assimilate glucose, while fructose remained almost intact. In contrast, the cultivation of M. indicus and R. oryzae in the four-liter airlift bioreactor resulted in the consumption of almost all sugars and production of 250 and 280 g fungal biomass per kg of consumed sugar, respectively. These biomasses correspondingly contained 40% and 51% protein and 9.8% and 4.4% oil. Furthermore, the fungal cell walls, obtained after removing the alkali soluble fraction of the fungi, contained 0.61 and 0.69 g chitin and chitosan per g of cell wall for M. indicus and R. oryzae, respectively. Moreover, the maximum ethanol yield of 36% and 18% was obtained from M. indicus and R. oryzae, respectively. Furthermore, that M. indicus grew as clump mycelia in the airlift bioreactor, while R. oryzae formed spherical suspended pellets, is a promising feature towards industrialization of the process. 

  • Souza Filho, Pedro Ferreira
    et al.
    Högskolan i Borås, Akademin för textil, teknik och ekonomi.
    Zamani, Akram
    Högskolan i Borås, Akademin för textil, teknik och ekonomi.
    Taherzadeh, Mohammad J
    Högskolan i Borås, Akademin för textil, teknik och ekonomi.
    Edible Protein Production by Filamentous Fungi using Starch Plant Wastewater2018Inngår i: Waste and Biomass Valorization, ISSN 1877-2641, s. 1-10Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The process to obtain starch from wheat requires high amounts of water, consequently generating large amounts of wastewater with very high environmental loading. This wastewater is traditionally sent to treatment facilities. This paper introduces an alternative method, where the wastewater of a wheat-starch plant is treated by edible filamentous fungi (Aspergillus oryzae and Rhizopus oryzae) to obtain a protein-rich biomass to be used as e.g. animal feed. The wastewater was taken from the clarified liquid of the first and second decanter (ED1 and ED2, respectively) and from the solid-rich stream (SS), whose carbohydrate and nitrogen concentrations ranged between 15 and 90 and 1.25–1.40 g/L, respectively. A. oryzae showed better performance than R. oryzae, removing more than 80% of COD after 3 days for ED1 and ED2 streams. Additionally, 12 g/L of dry biomass with protein content close to 35% (w/w) was collected, demonstrating the potential of filamentous fungi to be used in wastewater valorization. High content of fermentable solids in the SS sample led to high production of ethanol (10.91 g/L), which can be recovered and contribute to the economics of the process.

  • Taherzadeh, Mohammad J
    et al.
    Högskolan i Borås, Akademin för textil, teknik och ekonomi.
    Karimi, K.
    Department of Chemical Engineering, Isfahan University of Technology.
    Enzyme-based hydrolysis processes for ethanol from lignocellulosic materials: A review2007Inngår i: BioResources, ISSN 1930-2126, E-ISSN 1930-2126, Vol. 2, nr 4, s. 707-738Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    This article reviews developments in the technology for ethanol production from lignocellulosic materials by "enzymatic" processes. Several methods of pretreatment of lignocelluloses are discussed, where the crystalline structure of lignocelluloses is opened up, making them more accessible to the cellulase enzymes. The characteristics of these enzymes and important factors in enzymatic hydrolysis of the cellulose and hemicellulose to cellobiose, glucose, and other sugars are discussed. Different strategies are then described for enzymatic hydrolysis and fermentation, including separate enzymatic hydrolysis and fermentation (SHF), simultaneous saccharification and fermentation (SSF), non-isothermal simultaneous saccharification and fermentation (NSSF), simultaneous saccharification and co-fermentation (SSCF), and consolidated bioprocessing (CBP). Furthermore, the by-products in ethanol from lignocellulosic materials, wastewater treatment, commercial status, and energy production and integration are reviewed.

  • Zidar, Josefina
    et al.
    Linkoping Univ, Dept Phys Chem & Biol, IFM Biol, SE-58183 Linkoping, Sweden.
    Campderrich, Irene
    Swedish Univ Agr Sci, Dept Anim Environm & Hlth, SE-75007 Uppsala, Sweden;Neiker Tecnalia, Dept Anim Prod, Vitoria 01080, Spain.
    Jansson, Emelie
    Linkoping Univ, Dept Phys Chem & Biol, IFM Biol, SE-58183 Linkoping, Sweden.
    Wichman, Anette
    Swedish Univ Agr Sci, Dept Anim Environm & Hlth, SE-75007 Uppsala, Sweden.
    Winberg, Svante
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysiologi.
    Keeling, Linda
    Swedish Univ Agr Sci, Dept Anim Environm & Hlth, SE-75007 Uppsala, Sweden.
    Løvlie, Hanne
    Linkoping Univ, Dept Phys Chem & Biol, IFM Biol, SE-58183 Linkoping, Sweden.
    Environmental complexity buffers against stress-induced negative judgement bias in female chickens2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 5404Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Cognitive processes are often biased by emotions. In humans, affective disorders are accompanied by pessimistic judgement, while optimistic judgement is linked to emotional stability. Similar to humans, animals tend to interpret ambiguous stimuli negatively after experiencing stressful events, although the long-lasting impact on judgement bias has rarely been investigated. We measure judgement bias in female chicks (Gallus gallus domesticus) after exposure to cold stress, and before and after exposure to additional unpredictable stressors. Additionally, we explore if brain monoamines can explain differences in judgement bias. Chicks exposed to cold stress did not differ in judgement bias compared to controls, but showed sensitivity to additional stressors by having higher motivation for social reinstatement. Environmental complexity reduced stress-induced negative judgement bias, by maintaining an optimistic bias in individuals housed in complex conditions even after stress exposure. Moreover, judgement bias was related to dopamine turnover rate in mesencephalon, with higher activity in individuals that had a more optimistic response. These results demonstrate that environmental complexity can buffer against negative effects of additive stress and that dopamine relates to judgement bias in chicks. These results reveal that both internal and external factors can mediate emotionally biased judgement in animals, thus showing similarities to findings in humans.

  • Roman, Erika
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Brunberg, Ronja
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Mustafa, Arshi
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysiologi.
    Thörnqvist, Per-Ove
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysiologi.
    Winberg, Svante
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysiologi.
    Behavioral profiling using a modified version of the zebrafish multivariate concentric square field™ (zMCSF) test2018Inngår i: Measuring Behavior 2018: 11th International Conference on Methods and Techniques in Behavioral Research / [ed] Grant R, Allen T, Spink A, Sullivan M, 2018, s. 27-29Konferansepaper (Fagfellevurdert)
  • Tjernström, Nikita
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Roman, Erika
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Characterization of behavior and voluntary alcohol intake in Wistar and Lister Hooded rats2018Inngår i: Measuring Behavior 2018: 11th International Conference on Methods and Techniques in Behavioral Research / [ed] Grant R, Allen T, Spink A, Sullivan M, 2018, s. 437-442Konferansepaper (Fagfellevurdert)
  • Youngsukkasem, S.
    et al.
    Barghi, H.
    Chalmers University of Technology.
    Rakshit, S. K.
    Department of Chemical Engineering, Lakehead University.
    Taherzadeh, Mohammad J
    Högskolan i Borås, Akademin för textil, teknik och ekonomi.
    Rapid biogas production by compact multi-layer membrane bioreactor: Efficiency of synthetic polymeric membranes2013Inngår i: Energies, ISSN 1996-1073, E-ISSN 1996-1073, Vol. 6, nr 12, s. 6211-6224Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Entrapment of methane-producing microorganisms between semi-permeable synthetic membranes in a multi-layer membrane bioreactor (MMBR) was studied and compared to the digestion capacity of a free-cell digester, using a hydraulic retention time of one day and organic loading rates (OLR) of 3.08, 6.16, and 8.16 g COD/L day. The reactor was designed to retain bacterial cells with uprising plug flow through a narrow tunnel between membrane layers, in order to acquire maximal mass transfer in a compact bioreactor. Membranes of hydrophobic polyamide 46 (PA) and hydroxyethylated polyamide 46 (HPA) as well as a commercial membrane of polyvinylidene fluoride (PVDF) were examined. While the bacteria in the free-cell digester were washed out, the membrane bioreactor succeeded in retaining them. Cross-flow of the liquid through the membrane surface and diffusion of the substrate through the membranes, using no extra driving force, allowed the bacteria to receive nutrients and to produce biogas. However, the choice of membrane type was crucial. Synthesized hydrophobic PA membrane was not effective for this purpose, producing 50-121 mL biogas/day, while developed HPA membrane and the reference PVDF were able to transfer the nutrients and metabolites while retaining the cells, producing 1102-1633 and 1016-1960 mL biogas/day, respectively.

  • Fisher, Matthew C.
    et al.
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Infect Dis Epidemiol, St Marys Campus, London W2 1PG, England.
    Ghosh, Pria
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Infect Dis Epidemiol, St Marys Campus, London W2 1PG, England;North West Univ, Unit Environm Sci & Management, Private Bag x6001, ZA-2520 Potchefstroom, South Africa.
    Shelton, Jennifer M. G.
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Infect Dis Epidemiol, St Marys Campus, London W2 1PG, England.
    Bates, Kieran
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Infect Dis Epidemiol, St Marys Campus, London W2 1PG, England.
    Brookes, Lola
    Inst Zool, Regents Pk, London NW1 4RY, England.
    Wierzbicki, Claudia
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Infect Dis Epidemiol, St Marys Campus, London W2 1PG, England.
    Rosa, Goncalo M.
    Inst Zool, Regents Pk, London NW1 4RY, England;Univ Lisbon, Fac Ciencias, Ctr Ecol Evolut & Environm Changes CE3C, Lisbon, Portugal.
    Farrer, Rhys A.
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Infect Dis Epidemiol, St Marys Campus, London W2 1PG, England.
    Aanensen, David M.
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Infect Dis Epidemiol, St Marys Campus, London W2 1PG, England;Ctr Genom Pathogen Surveillance, Wellcome Genome Campus, Hinxton, Cambs, England.
    Alvarado-Rybak, Mario
    Univ Andres Bello, Fac Ecol & Recursos Nat, Ctr Invest Sustentabilidad, Republ 440, Santiago, Chile.
    Bataille, Arnaud
    Seoul Natl Univ, Sch Biol Sci, Lab Behav & Populat Ecol, Seoul 08826, South Korea;CIRAD, UMR ASTRE, F-34398 Montpellier, France;Univ Montpellier, ASTRE, CIRAD, INRA, Montpellier, France.
    Berger, Lee
    James Cook Univ, Coll Publ Hlth Med & Vet Sci, Hlth Res Grp 1, Townsville, Qld 4811, Australia.
    Böll, Susanne
    Agcy Populat Ecol & Nat Conservancy, Gerbrunn, Germany.
    Bosch, Jaime
    CSIC, Museo Nacl Ciencias Nat, C Jose Gutierrez Abascal 2, E-28006 Madrid, Spain.
    Clare, Frances C.
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Infect Dis Epidemiol, St Marys Campus, London W2 1PG, England.
    Courtois, Elodie A.
    Univ Guyane, CNRS, IFREMER, LEEISA, Cayenne 97300, French Guiana.
    Crottini, Angelica
    Univ Porto, InBIO, CIBIO Ctr Invest Biodiversidade & Recursos Genet, P-4485661 Vairao, Portugal.
    Cunningham, Andrew A.
    Inst Zool, Regents Pk, London NW1 4RY, England.
    Doherty-Bone, Thomas M.
    Royal Zool Soc Scotland, Conservat Programmes, Edinburgh, Midlothian, Scotland.
    Gebresenbet, Fikirte
    Oklahoma State Univ, Dept Integrat Biol, Life Sci West 113, Stillwater, OK 74078 USA.
    Gower, David J.
    Nat Hist Museum, Life Sci, London SW7 5BD, England.
    Höglund, Jacob
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    James, Timothy Y.
    Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA.
    Jenkinson, Thomas S.
    Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA.
    Kosch, Tiffany A.
    Seoul Natl Univ, Sch Biol Sci, Lab Behav & Populat Ecol, Seoul 08826, South Korea;James Cook Univ, Coll Publ Hlth Med & Vet Sci, Hlth Res Grp 1, Townsville, Qld 4811, Australia.
    Lambertini, Carolina
    Univ Estadual Campinas, Inst Biol, Dept Biol Anim, Lab Hist Nat Anfibios Brasileiros, BR-13083862 Campinas, SP, Brazil.
    Laurila, Anssi
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Lin, Chun-Fu
    Endem Species Res Inst, Zool Div, 1 Ming Shen East Rd, Nantou 552, Taiwan.
    Loyau, Adeline
    UFZ Helmholtz Ctr Environm Res, Dept Conservat Biol, Permoserstr 15, D-04318 Leipzig, Germany;Univ Toulouse, CNRS, ECOLAB, INPT,UPS, Toulouse, France.
    Martel, An
    Univ Ghent, Dept Pathol Bacteriol & Avian Dis, Fac Vet Med, Salisburylaan 133, B-9820 Merelbeke, Belgium.
    Meurling, Sara
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Zooekologi.
    Miaud, Claude
    Univ Paul Valery Montpellier, Univ Montpellier, PSL Res Univ, CEFE,UMR 5175,CNRS,EPHE,Biogeog & Ecol Vertebres, Montpellier, France.
    Minting, Pete
    Amphibian & Reptile Conservat ARC Trust, 655A Christchurch Rd, Bournemouth BH1 4AP, Dorset, England.
    Ndriantsoa, Serge
    Durrell Wildlife Conservat Trust, Madagascar Programme, Antananarivo, Madagascar.
    O'Hanlon, Simon J.
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Infect Dis Epidemiol, St Marys Campus, London W2 1PG, England;Inst Zool, Regents Pk, London NW1 4RY, England.
    Pasmans, Frank
    Univ Ghent, Dept Pathol Bacteriol & Avian Dis, Fac Vet Med, Salisburylaan 133, B-9820 Merelbeke, Belgium.
    Rakotonanahary, Tsanta
    Durrell Wildlife Conservat Trust, Madagascar Programme, Antananarivo, Madagascar.
    Rabemananjara, Falitiana C. E.
    Durrell Wildlife Conservat Trust, Madagascar Programme, Antananarivo, Madagascar;IUCN SSC Amphibian Specialist Grp Madagascar, Antananarivo 101, Madagascar.
    Ribeiro, Luisa P.
    Univ Estadual Campinas, Inst Biol, Dept Biol Anim, Lab Hist Nat Anfibios Brasileiros, BR-13083862 Campinas, SP, Brazil.
    Schmeller, Dirk S.
    UFZ Helmholtz Ctr Environm Res, Dept Conservat Biol, Permoserstr 15, D-04318 Leipzig, Germany;Univ Toulouse, CNRS, ECOLAB, INPT,UPS, Toulouse, France.
    Schmidt, Benedikt R.
    Univ Zurich, Dept Evolutionary Biol & Environm Studies, Winterthurerstr 190, CH-8057 Zurich, Switzerland;Univ Neuchatel, Info Fauna Karch, Bellevaux 51,UniMail Batiment 6, CH-2000 Neuchatel, Switzerland.
    Skerratt, Lee
    James Cook Univ, Coll Publ Hlth Med & Vet Sci, Hlth Res Grp 1, Townsville, Qld 4811, Australia.
    Smith, Freya
    APHA, Natl Wildlife Management Ctr, Woodchester Pk GL10 3UJ, Glos, England.
    Soto-Azat, Claudio
    Univ Andres Bello, Fac Ecol & Recursos Nat, Ctr Invest Sustentabilidad, Republ 440, Santiago, Chile.
    Tessa, Giulia
    Nonprofit Assoc Zirichiltaggi Sardinia Wildlife C, Str Vicinale Filigheddu 62-C, I-07100 Sassari, Italy.
    Toledo, Luis Felipe
    Univ Estadual Campinas, Inst Biol, Dept Biol Anim, Lab Hist Nat Anfibios Brasileiros, BR-13083862 Campinas, SP, Brazil.
    Valenzuela-Sanchez, Andres
    Univ Andres Bello, Fac Ecol & Recursos Nat, Ctr Invest Sustentabilidad, Republ 440, Santiago, Chile;ONG Ranita Darwin, Nataniel Cox 152, Santiago, Chile.
    Verster, Ruhan
    North West Univ, Unit Environm Sci & Management, Private Bag x6001, ZA-2520 Potchefstroom, South Africa.
    Vörös, Judit
    Hungarian Nat Hist Museum, Dept Zool, Collect Amphibians & Reptiles, Baross U 13, H-1088 Budapest, Hungary.
    Waldman, Bruce
    Seoul Natl Univ, Sch Biol Sci, Lab Behav & Populat Ecol, Seoul 08826, South Korea.
    Webb, Rebecca J.
    James Cook Univ, Coll Publ Hlth Med & Vet Sci, Hlth Res Grp 1, Townsville, Qld 4811, Australia.
    Weldon, Che
    North West Univ, Unit Environm Sci & Management, Private Bag x6001, ZA-2520 Potchefstroom, South Africa.
    Wombwell, Emma
    Inst Zool, Regents Pk, London NW1 4RY, England.
    Zamudio, Kelly R.
    Cornell Univ, Dept Ecol & Evolutionary Biol, Ithaca, NY 14853 USA.
    Longcore, Joyce E.
    Univ Maine, Sch Biol & Ecol, Orono, ME 04469 USA.
    Garner, Trenton W. J.
    Inst Zool, Regents Pk, London NW1 4RY, England;Nonprofit Assoc Zirichiltaggi Sardinia Wildlife C, Str Vicinale Filigheddu 62-C, I-07100 Sassari, Italy;North West Univ, Unit Environm Sci & Management, Private Bag x6001, ZA-2520 Potchefstroom, South Africa.
    Development and worldwide use of non-lethal, and minimal population-level impact, protocols for the isolation of amphibian chytrid fungi2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 7772Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Parasitic chytrid fungi have emerged as a significant threat to amphibian species worldwide, necessitating the development of techniques to isolate these pathogens into culture for research purposes. However, early methods of isolating chytrids from their hosts relied on killing amphibians. We modified a pre-existing protocol for isolating chytrids from infected animals to use toe clips and biopsies from toe webbing rather than euthanizing hosts, and distributed the protocol to researchers as part of the BiodivERsA project RACE; here called the RML protocol. In tandem, we developed a lethal procedure for isolating chytrids from tadpole mouthparts. Reviewing a database of use a decade after their inception, we find that these methods have been applied across 5 continents, 23 countries and in 62 amphibian species. Isolation of chytrids by the non-lethal RML protocol occured in 18% of attempts with 207 fungal isolates and three species of chytrid being recovered. Isolation of chytrids from tadpoles occured in 43% of attempts with 334 fungal isolates of one species (Batrachochytrium dendrobatidis) being recovered. Together, these methods have resulted in a significant reduction and refinement of our use of threatened amphibian species and have improved our ability to work with this group of emerging pathogens.

  • Johansson, Annika
    Stockholms universitet, Humanistiska fakulteten, Institutionen för slaviska och baltiska språk, finska, nederländska och tyska.
    Tredjespråksinlärning och metalingvistisk medvetenhet - ett didaktiskt perspektiv2018Inngår i: Tijdschrift voor Skandinavistiek, ISSN 1875-9505, Vol. 36, nr 2, s. 182-188Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The contribution deals with third language acquisition and metalinguistic awareness in relation to Swedish and Dutch. The use of posture verbs in the above-mentioned languages is outlined to exemplify the outcome of focusing on metalinguistic awareness in language acquisition as a didactic tool. The contribution will discuss the set up and results of a cloze test taken by Swedish-speaking learners of Dutch, which measures the accurate use of posture verbs.

  • Youngsukkasem, S.
    et al.
    Rakshit, S. K.
    Taherzadeh, Mohammad J
    Högskolan i Borås, Akademin för textil, teknik och ekonomi.
    Biogas production by encapsulated methaneproducing bacteria2012Inngår i: BioResources, ISSN 1930-2126, E-ISSN 1930-2126, Vol. 7, nr 1, s. 56-65Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Encapsulation of methane-producing bacteria was carried out with the objective of enhancing the rate of biogas production. Encapsulation with a one-step liquid-droplet-forming technique was employed for the natural membrane, resulting in spherical capsules with an average diameter and a membrane thickness of 4.3 and 0.2 mm, respectively. The capsules were made from alginate, using chitosan or Ca 2+ as counter-ions, together with the addition of carboxymethylcellulose (CMC). A Durapore® membrane (hydrophilic PVDF) with a pore size of 0.1 μm was used for synthetic encapsulating sachets having width and length dimensions 3×3 and 3×6 cm 2 for holding the bacteria. During the digesting process, the dissolved substrates penetrated through the capsule membrane, and biogas inside the capsules was able to escape by diffusion. The results indicate encapsulation to be a promising method of digestion, with a high density of anaerobic bacteria. The method holds considerable potential for further development of membranes and their applications.

  • Strömbom, Daniel
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Matematiska institutionen, Tillämpad matematik och statistik. Swansea Univ, Dept Biosci, Swansea, W Glam, Wales.
    King, Andrew J.
    Swansea Univ, Dept Biosci, Swansea, W Glam, Wales.
    Robot Collection and Transport of Objects: A Biomimetic Process2018Inngår i: Frontiers in Robotics and AI, E-ISSN 2296-9144, Vol. 5, artikkel-id 48Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Animals as diverse as ants and humans are faced with the tasks of collecting, transporting or herding objects. Sheepdogs do this daily when they collect, herd, and maneuver flocks of sheep. Here, we adapt a shepherding algorithm inspired by sheepdogs to collect and transport objects using a robot. Our approach produces an effective robot collection process that autonomously adapts to changing environmental conditions and is robust to noise from various sources. We suggest that this biomimetic process could be implemented into suitable robots to perform collection and transport tasks that might include - for example - cleaning up objects in the environment, keeping animals away from sensitive areas or collecting and herding animals to a specific location. Furthermore, the feedback controlled interactions between the robot and objects which we study can be used to interrogate and understand the local and global interactions of real animal groups, thus offering a novel methodology of value to researchers studying collective animal behavior.

  • Sörlin, Sverker
    Filosofi och historia, KTH, Skolan för arkitektur och samhällsbyggnad (ABE), Filosofi och teknikhistoria, Historiska studier av teknik, vetenskap och miljö.
    Reform and responsibility:: the climate of history in times of transformation2018Inngår i: Historisk Tidsskrift, ISSN 0018-263X, E-ISSN 1504-2944, ISSN 1504-2944-2018-01-02, Vol. 97, nr 1, s. 7-23Artikkel i tidsskrift (Fagfellevurdert)
  • Stenmark, Mikael
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen, Tros- och livsåskådningsvetenskap, Religionsfilosofi.
    Johannesson, KarinUppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen, Tros- och livsåskådningsvetenskap, Religionsfilosofi.Jonbäck, FrancisUppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen, Tros- och livsåskådningsvetenskap, Religionsfilosofi.Zackariasson, UlfUppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen, Tros- och livsåskådningsvetenskap, Religionsfilosofi.
    Filosofiska metoder i praktiken2018Collection/Antologi (Fagfellevurdert)
  • Ghorbani, Ramin
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för tillämpad fysik och elektronik.
    Blomberg, Anders
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
    Schmidt, Florian M.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för tillämpad fysik och elektronik.
    Modeling pulmonary gas exchange and single-exhalation profiles of carbon monoxide2018Inngår i: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 9, artikkel-id 927Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Exhaled breath carbon monoxide (eCO) is a candidate biomarker for non-invasive assessment of oxidative stress and respiratory diseases. Standard end-tidal CO analysis, however, cannot distinguish, whether eCO reflects endogenous CO production, lung diffusion properties or exogenous sources, and is unable to resolve a potential airway contribution. Coupling real-time breath gas analysis to pulmonary gas exchange modeling holds promise to improve the diagnostic value of eCO. A trumpet model with axial diffusion (TMAD) is used to simulate the dynamics of CO gas exchange in the respiratory system and corresponding eCO concentrations for the first time. The mass balance equation is numerically solved employing a computationally inexpensive routine implementing the method of lines, which provides the distribution of CO in the respiratory tract during inhalation, breath-holding and exhalation with 1 mm spatial and 0.01 s temporal resolution. Initial estimates of the main TMAD parameters, the maximum CO fluxes and diffusing capacities in alveoli and airways, are obtained using healthy population tissue, blood and anatomical data. To verify the model, mouth-exhaled expirograms from two healthy subjects, measured with a novel, home-built laser-based CO sensor, are compared to single-exhalation profiles simulated using actual breath sampling data, such as exhalation flow rate (EFR) and volume. A very good agreement is obtained in exhalation phases I and III for EFRs between 55 and 220 ml/s and after 10 s and 20 s of breath-holding, yielding a unique set of TMAD parameters. The results confirm the recently observed EFR dependence of CO expirograms and suggest that measured end-tidal eCO is always lower than alveolar and capillary CO. Breath-holding allows the observation of close-to-alveolar CO concentrations and increases the sensitivity to the airway TMAD parameters in exhalation phase I. A parametric simulation study shows that a small increase in airway flux can be distinguished from an increase in alveolar flux, and that slight changes in alveolar flux and diffusing capacity have a significantly different effect on phase III of the eCO profiles.

  • Henderson, Ben
    et al.
    Khodabakhsh, Amir
    Metsälä, Markus
    Ventrillard, Irène
    Schmidt, Florian M.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för tillämpad fysik och elektronik.
    Romanini, Daniele
    Ritchie, Grant A. D.
    te Lintel Hekkert, Sacco
    Briot, Raphaël
    Risby, Terence
    Marczin, Nandor
    Harren, Frans J. M.
    Cristescu, Simona M.
    Laser spectroscopy for breath analysis: towards clinical implementation2018Inngår i: Applied physics. B, Lasers and optics (Print), ISSN 0946-2171, E-ISSN 1432-0649, Vol. 124, nr 8, artikkel-id 161Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Detection and analysis of volatile compounds in exhaled breath represents an attractive tool for monitoring the metabolic status of a patient and disease diagnosis, since it is non-invasive and fast. Numerous studies have already demonstrated the benefit of breath analysis in clinical settings/applications and encouraged multidisciplinary research to reveal new insights regarding the origins, pathways, and pathophysiological roles of breath components. Many breath analysis methods are currently available to help explore these directions, ranging from mass spectrometry to laser-based spectroscopy and sensor arrays. This review presents an update of the current status of optical methods, using near and mid-infrared sources, for clinical breath gas analysis over the last decade and describes recent technological developments and their applications. The review includes: tunable diode laser absorption spectroscopy, cavity ring-down spectroscopy, integrated cavity output spectroscopy, cavity-enhanced absorption spectroscopy, photoacoustic spectroscopy, quartz-enhanced photoacoustic spectroscopy, and optical frequency comb spectroscopy. A SWOT analysis (strengths, weaknesses, opportunities, and threats) is presented that describes the laser-based techniques within the clinical framework of breath research and their appealing features for clinical use.

  • Lövheim, Mia
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen.
    Jernsletten, Haakon
    Herbert, David
    Kingston University.
    Lundby, Knut
    Oslo University.
    Hjarvard, Stig
    University of Copenhagen .
    Attitudes: Tendencies and Variations2018Inngår i: Contesting Religion: The Media Dynamics of Cultural Conflicts in Scandinavia / [ed] Knut Lundby, Berlin, Boston: De Gruyter Open, 2018, 1, s. 33-50Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    This chapter presents an overview of religiosity and attitudes to religious diversity in media and other public spaces based on a cross-Scandinavian survey conducted in 2015. Although Scandinavians in general have a weak personal connection to religion, Christianity still holds a privileged position as an expression of cultural identity. Scandinavians express support for equal rights to practice religion, but also doubtfulness towards public expressions of religion. More than one-fourth of respondents discuss news about religion and religious extremism regularly. There is a widespread sentiment that Islam is a threat to the national culture, even though most respondents state that they oppose an open expression of hostile attitudes towards foreigners. Political orientation and gender are salient aspects that shape diverging opinions regarding tolerance or scepticism towards the public visibility of religious diversity. Furthermore, Danes and Norwegians are more critical of public expressions of Islam than Swedes.

  • Lövheim, Mia
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen.
    Jensdotter, Linnea
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen.
    Contradicting Ideals: Islam on Swedish Public Service Radio2018Inngår i: Contesting Religion.: The Media Dynamics of Cultural Conflicts in Scandinavia / [ed] Knut Lundby, De Gruyter Open, 2018, 1, s. 135-152Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    Cultural and religious diversity are contested topics in Swedish public debate. This chapter analyses how the radio programme Människor och tro (People and belief) enables and structures the actors and issues that become heard in this debate, particularly with regard to Islam and Muslims. The programme aims to present an alternative to the dominant negative media discourses by equally representing Christianity and Islam in reports, inviting Swedish Muslims to present experiences and opinions on various news events, and enabling debate between religious organizations, experts, and listeners through phone-in sessions and social media. Despite these efforts, the programme tends to reconstruct, as well as challenge, the dominant frames of Islam as a problem for Swedish society and for the relations of power between the majority and minority voices in public debates. The chapter explores how contradictions between the traditional ideals and formats of public service radio and its ambitions to produce a more nuanced and diverse image of religion contribute to this outcome.

  • Lövheim, Mia
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Teologiska fakulteten, Teologiska institutionen.
    Lied, Ingeborg Liv
    Approaching Contested Religion2018Inngår i: Contesting Religion.: The Media Dynamics of Cultural Conflicts in Scandinavia / [ed] Knut Lundby, De Gruyter Open, 2018, 1, s. 65-80Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    Religion has become a matter of intensified public concern in contem- porary Scandinavia, and the various media are the main arena in which Scandi- navians encounter such controversies. Historically-rooted understandings of re- ligion that are based on the Lutheran Church as both a public utility and cultural resource, and the secular state as the regulator of religious freedom and equality, have become re-articulated in newly emerging frames such as the politicization, culturalization and securitization of religion. This chapter presents the current volume’s overall approach to religion in contemporary Scandinavia as a mediatized and contested social phenomenon. The chapter ad- vocates a perspective from which ongoing contestations and negotiations among a larger spectrum of actors are explored through an application of both substan- tive and moderate social constructionist approaches to religion. The various ap- plications and interplays of these approaches to religion may fruitfully contrib- ute to the further development of the theory of the mediatization of religion.

  • Söllvander, Sofia
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Nikitidou, Elisabeth
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Gallasch, Linn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Zysk, Marlena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Söderberg, Linda
    BioArctic AB, Warfvinges Vag 35, SE-11251 Stockholm, Sweden.
    Sehlin, Dag
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Lannfelt, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Erlandsson, Anna
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    The A beta protofibril selective antibody mAb158 prevents accumulation of A beta in astrocytes and rescues neurons from A beta-induced cell death2018Inngår i: Journal of Neuroinflammation, ISSN 1742-2094, E-ISSN 1742-2094, Vol. 15, artikkel-id 98Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Currently, several amyloid beta (A beta) antibodies, including the protofibril selective antibody BAN2401, are in clinical trials. The murine version of BAN2401, mAb158, has previously been shown to lower the levels of pathogenic A beta and prevent A beta deposition in animal models of Alzheimer's disease (AD). However, the cellular mechanisms of the antibody's action remain unknown. We have recently shown that astrocytes effectively engulf A beta(42) protofibrils, but store rather than degrade the ingested A beta aggregates. In a co-culture set-up, the incomplete degradation of A beta(42) protofibrils by astrocytes results in increased neuronal cell death, due to the release of extracellular vesicles, containing N-truncated, neurotoxic A beta. Methods: The aim of the present study was to investigate if the accumulation of A beta in astrocytes can be affected by the A beta protofibril selective antibody mAb158. Co-cultures of astrocytes, neurons, and oligodendrocytes, derived from embryonic mouse cortex, were exposed to A beta(42) protofibrils in the presence or absence of mAb158. Results: Our results demonstrate that the presence of mAb158 almost abolished A beta accumulation in astrocytes. Consequently, mAb158 treatment rescued neurons from A beta-induced cell death. Conclusion: Based on these findings, we conclude that astrocytes may play a central mechanistic role in anti-A beta immunotherapy.

  • Granath Hansson, Anna
    KTH, Skolan för arkitektur och samhällsbyggnad (ABE).
    Bostadspolitiska instrument i fyra europeiska länder: Nyproducerade bostäder som låg- och medelinkomsttagare kan efterfråga2018Rapport (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Ett ökat bostadsbyggande för låg- och medelinkomsttagare kan främjas dels genom generella utbudsstimulerande åtgärder, som t.ex. regelförenklingar, dels genom åtgärder som är direkt riktade till hushåll med lägre inkomster. Riktade åtgärder används i många länder för att komplettera de generella utbudsstimulerande åtgärderna i de fall sådana åtgärder inte räcker för att täcka den politiskt definierade behovsbaserade bostadsbristen. Den här rapporten tar upp modeller för bostadsförsörjning som används i Danmark, Nederländerna, Tyskland och Österrike med fokus på 1) offentligt understött bostadsbyggande för låg- och medelinkomsttagare, 2) reform av det institutionella ramverket kring bostadsbyggandet exemplifierat av det seriella bostadsbyggandet, 3) kommunal bostadsbyggnadsstrategi och bostadsallianser i Berlin och Hamburg och 4) inkluderande bostadsbyggande. Avslutningsvis diskuteras hur de presenterade bostadspolitiska instrumenten relaterar till det svenska bostadssystemet.

  • Maric, Jovana
    et al.
    Med Univ Graz, Inst Expt & Clin Pharmacol, Graz, Austria;Karolinska Inst, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden.
    Ravindran, Avinash
    Karolinska Inst, Dept Med, Immunol & Allergy Unit, Stockholm, Sweden.
    Mazzurana, Luca
    Karolinska Inst, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden.
    Björklund, Åsa K.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär evolution. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Van Acker, Aline
    Karolinska Inst, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden.
    Rao, Anna
    Karolinska Inst, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden.
    Friberg, Danielle
    Karolinska Univ Hosp, Dept Otorhinolaryngol, Stockholm, Sweden;Karolinska Inst, CLINTEC, Stockholm, Sweden.
    Dahlen, Sven-Erik
    Karolinska Inst, Inst Environm Med, Expt Asthma & Allergy Res, Stockholm, Sweden.
    Heinemann, Akos
    Med Univ Graz, Inst Expt & Clin Pharmacol, Graz, Austria.
    Konya, Viktoria
    Med Univ Graz, Inst Expt & Clin Pharmacol, Graz, Austria;Karolinska Inst, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden.
    Mjösberg, Jenny
    Karolinska Inst, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden.
    Prostaglandin E-2 suppresses human group 2 innate lymphoid cell function2018Inngår i: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 141, nr 5, s. 1761-1773.e6Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Group 2 innate lymphoid cells (ILC2s) are involved in the initial phase of type 2 inflammation and can amplify allergic immune responses by orchestrating other type 2 immune cells. Prostaglandin (PG) E-2 is a bioactive lipid that plays protective roles in the lung, particularly during allergic inflammation.

    Objective: We set out to investigate how PGE(2) regulates human ILC2 function.

    Methods: The effects of PGE(2) on human ILC2 proliferation and intracellular cytokine and transcription factor expression were assessed by means of flow cytometry. Cytokine production was measured by using ELISA, and real-time quantitative PCR was performed to detect PGE(2) receptor expression.

    Results: PGE(2) inhibited GATA-3 expression, as well as production of the type 2 cytokines IL-5 and IL-13, from human tonsillar and blood ILC2s in response to stimulation with a combination of IL-25, IL-33, thymic stromal lymphopoietin, and IL-2. Furthermore, PGE(2) downregulated the expression of IL-2 receptor alpha (CD25). In line with this observation, PGE(2) decreased ILC2 proliferation. These effects were mediated by the combined action of E-type prostanoid receptor (EP) 2 and EP4 receptors, which were specifically expressed on ILC2s.

    Conclusion: Our findings reveal that PGE(2) limits ILC2 activation and propose that selective EP2 and EP4 receptor agonists might serve as a promising therapeutic approach in treating allergic diseases by suppressing ILC2 function.

  • Beckman, Ludvig
    et al.
    Stockholm Univ, Dept Polit Sci, S-10691 Stockholm, Sweden.
    Hultin Rosenberg, Jonas
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Statsvetenskapliga institutionen.
    Freedom as Non-domination and Democratic Inclusion2018Inngår i: Res Publica, ISSN 1356-4765, E-ISSN 1572-8692, Vol. 24, nr 2, s. 181-198Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    According to neo-republicans, democracy is morally justified because it is among the prerequisites for freedom as non-domination. The claim that democracy secures freedom as non-domination needs to explain why democratic procedures contribute to non-domination and for whom democracy secures non-domination. This requires an account of why domination is countered by democratic procedures and an account of to whom domination is countered by access to democratic procedures. Neo-republican theory of democracy is based on a detailed discussion of the former but a scant discussion of the latter. We address this lacuna by interpreting the two most influential principles of inclusion, the all-subjected principle and the all-affected principle, in light of neo-republican commitments. The preliminary conclusion is that both principles are able to capture relations of domination between the democratic state and the people controlled by it in the relevant sense. Yet, the state has virtually unlimited powers to control residents, but only limited powers to interfere in the lives of non-residents. Republican aspirations are therefore more in tune with the all-subjected principle according to which only residents in the territory of the state should be granted rights to political participation.

  • Mortensen, Anja
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk strålningsvetenskap.
    Spiegelberg, Diana
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk strålningsvetenskap.
    Haylock, Anna-Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
    Lundqvist, Hans
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk strålningsvetenskap.
    Nestor, Marika
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk strålningsvetenskap.
    Preclinical evaluation of a novel engineered recombinant human anti-CD44v6 antibody for potential use in radio-immunotherapy2018Inngår i: International Journal of Oncology, ISSN 1019-6439, Vol. 52, nr 6, s. 1875-1885Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    CD44v6 is overexpressed in a variety of cancers, rendering it a promising target for radio-immunotherapy (RIT). In this study, we have characterized a novel engineered recombinant monoclonal anti-CD44v6 antibody, AbN44v6, and assessed its potential for use in RIT using either Lu-177 or I-131 as therapeutic radionuclides. In vitro affinity and specificity assays characterized the binding of the antibody labeled with Lu-177, I-125 or I-131. The therapeutic effects of Lu-177-AbN44v6 and I-131-AbN44v6 were investigated using two in vitro 3D tumor models with different CD44v6 expression. Finally, the normal tissue biodistribution and dosimetry for Lu-177-AbN44v6 and I-125-AbN44v6/I-131-AbN44v6 were assessed in vivo using a mouse model. All AbN44v6 radioconjugates demonstrated CD44v6-specific binding in vitro. In the in vitro 3D tumor models, dose-dependent therapeutic effects were observed with both Lu-177-AbN44v6 and I-131-AbN44v6, with a greater significant therapeutic effect observed on the cells with a higher CD44v6 expression. Biodistribution experiments demonstrated a greater uptake of Lu-177-AbN44v6 in the liver, spleen and bone, compared to I-125-AbN44v6, whereas I-125-AbN44v6 demonstrated a longer circulation time. In dosimetric calculations, the critical organs for Lu-177-AbN44v6 were the liver and spleen, whereas the kidneys and red marrow were considered the critical organs for I-131-AbN44v6. The effective dose was in the order of 0.1 mSv/MBq for both labels. In conclusion, AbN44v6 bound specifically and with high affinity to CD44v6. Furthermore, in vitro RIT demonstrated growth inhibition in a CD44v6-specific activity-dependent manner for both radioconjugates, demonstrating that both Lu-177-AbN44v6 and I-131-AbN44v6 may be promising RIT candidates. Furthermore, biodistribution and dosimetric analysis supported the applicability of both conjugates for RIT. The CD44v6-specific therapeutic effects observed with radiolabeled AbN44v6 in the 3D tumor models in vitro, combined with the beneficial dosimetry in vivo, render AbN44v6 a potential candidate for RIT.

  • Toonen, Willem H. J.
    et al.
    Aberystwyth Univ, Dept Geog & Earth Sci, Aberystwyth, Dyfed, Wales.
    Graham, Angus
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för arkeologi och antik historia, Arkeologi.
    Pennington, Benjamin T.
    Univ Southampton, Dept Geog & Environm, Southampton, Hants, England.
    Hunter, Morag A.
    Univ Cambridge, Dept Earth Sci, Cambridge, England.
    Strutt, Kristian D.
    Univ Southampton, Dept Archaeol, Southampton, Hants, England.
    Barker, Dominic S.
    Univ Southampton, Dept Archaeol, Southampton, Hants, England.
    Masson-Berghoff, Aurelia
    British Museum, Dept Greece & Rome, London, England.
    Emery, Virginia L.
    Carthage Coll, Kenosha, WI USA.
    Holocene fluvial history of the Nile's west bank at ancient Thebes, Luxor, Egypt, and its relation with cultural dynamics and basin-wide hydroclimatic variability2018Inngår i: Geoarchaeology, ISSN 0883-6353, E-ISSN 1520-6548, Vol. 33, nr 3, s. 273-290Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In the Theban area around modern Luxor (Egypt), the River Nile divides the temple complexes of Karnak and Luxor from New Kingdom royal cult temples on the western desert edge. Few sites have been archaeologically identified in the western flood plain, despite its presumed pivotal role in the ancient ritual landscape as the territory that both physically divided and symbolically connected the areas inhabited by the living and the areas occupied by the dead. Using borehole data and electrical resistivity tomography, the current investigation of subsurface deposits reveals the location of an abandoned channel of the Nile. This river course was positioned in the western, distal part of the Nile flood plain. Over 2100 ceramic fragments recovered from boreholes date the abandonment of the relatively minor river channel to the (late) New Kingdom. This minor river branch could have played an important role in the cultural landscape, as it would have served to connect important localities in the ritual landscape. Changes in the fluvial landscape match with established periods of basin-wide hydroclimatic variability. This links cultural and landscape changes observed on a regional scale to hydroclimatic dynamics in the larger Nile catchment, in one of the focal areas of Ancient Egyptian cultural development.

  • Fulle, Marco
    et al.
    INAF, Osservatorio Astron, Via Tiepolo 11, I-34143 Trieste, Italy.
    Bertini, I.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Ossevatorio 3, I-35122 Padua, Italy.
    Della Corte, V.
    INAF, Ist Astrofis & Planetol Spaziali, Via Fosso del Cavaliere 100, I-00133 Rome, Italy;Univ Napoli Parthenope, Dip Sci & Technol, CDN IC4, I-80143 Naples, Italy.
    Guttler, C.
    Max Planck Inst Stromungsforsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany.
    Ivanovski, S.
    INAF, Ist Astrofis & Planetol Spaziali, Via Fosso del Cavaliere 100, I-00133 Rome, Italy;Univ Napoli Parthenope, Dip Sci & Technol, CDN IC4, I-80143 Naples, Italy.
    La Forgia, F.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Ossevatorio 3, I-35122 Padua, Italy.
    Lasue, J.
    Uni Tolouse, UPS OMP, IRAP, I-31400 Toulouse, France;CNRS, IRAP, 9 Ave Colonel Roche,BP 44346, E-31028 Toulouse 4, France.
    Levasseur-Regourd, A. C.
    Sorbonne Univ, UVSQ UPSay, CNRS INSU, LATMOS IPSL, BC 102,Campus UPMC,4 Pl Jussieu, F-75005 Paris, France.
    Marzari, F.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Ossevatorio 3, I-35122 Padua, Italy.
    Moreno, F.
    CSIC, Inst Astrofis Andalucia, E-18008 Granada, Spain.
    Mottola, S.
    Inst Planetenforsch, Deutsch Zentrum Luft & Raumfahrt DLR, Rutherfordstr 2, D-12489 Berlin, Germany.
    Naletto, G.
    Univ Padua, Dept Phys & Astron G Galilei, Via Marzolo 8, I-35131 Padua, Italy;Univ Padua, Ctr Studies & Act Space, CISAS, Via Venezia 15, I-35131 Padua, Italy;CNR, IFN UOS Padova LUXOR, Via Trasea 7, I-35131 Padua, Italy.
    Palumbo, P.
    Univ Napoli Parthenope, Dip Sci & Technol, CDN IC4, I-80143 Naples, Italy.
    Rinaldi, G.
    INAF, Ist Astrofis & Planetol Spaziali, Via Fosso del Cavaliere 100, I-00133 Rome, Italy;Univ Napoli Parthenope, Dip Sci & Technol, CDN IC4, I-80143 Naples, Italy.
    Rotundi, A.
    Univ Napoli Parthenope, Dip Sci & Technol, CDN IC4, I-80143 Naples, Italy.
    Sierks, H.
    Max Planck Inst Stromungsforsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany.
    Barbieri, C.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Ossevatorio 3, I-35122 Padua, Italy.
    Lamy, P. L.
    CNRS, UMR 7326, Lab Astrophys Marseille, F-13388 Marseille 13, France;Aix Marseille Univ, F-13388 Marseille 13, France.
    Rodrigo, R.
    CSIC, Ctr Astrobiol, INTA, E-28850 Madrid, Spain;Int Space Sci Inst, Hallerstr 6, CH-3012 Bern, Switzerland.
    Koschny, D.
    ESA, Sci Support Off, European Space Res & Technol Ctr, Keplerlaan 1,Postbus 299, NL-2201 AZ Noordwijk, Netherlands.
    Rickman, Hans
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Teoretisk astrofysik. Space Res Ctr, Bartycka 18A, PL-00716 Warsaw, Poland.
    Barucci, M. A.
    Univ Paris 06, UPMC, Sorbonne Univ,Observ Paris, Sorbonne Paris Cite,Univ Paris Diderot,PSL Res Un, 5 Pl Jules Janssen, F-11111 Paris, France.
    Bertaux, J. -L
    Bodewits, D.
    Univ Maryland, Dept Astron, College Pk, MD 20742 USA.
    Cremonese, G.
    INAF, Osservatorio Astron Padova, Vicolo Osservatorio 5, I-35122 Padua, Italy.
    Da Deppo, V.
    CNR, IFN UOS Padova LUXOR, Via Trasea 7, I-35131 Padua, Italy.
    Davidsson, B.
    Jet Prop Lab, M-S 183-301,4800 Oak Grove Dr, Pasadena, CA 91109 USA.
    Debei, S.
    Univ Padua, Dept Ind Engn, Via Venezia 1, I-35131 Padua, Italy.
    De Cecco, M.
    Univ Trento, Fac Engn, Via Mesiano 77, I-38121 Trento, Italy.
    Deller, J.
    Max Planck Inst Stromungsforsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany.
    Fornasier, S.
    Univ Paris 06, UPMC, Sorbonne Univ,Observ Paris, Sorbonne Paris Cite,Univ Paris Diderot,PSL Res Un, 5 Pl Jules Janssen, F-11111 Paris, France.
    Groussin, O.
    Aix Marseille Univ, CNRS, LAM, UMR 7326, F-13388 Marseille, France.
    Gutierrez, P. J.
    CSIC, Inst Astrofis Andalucia, E-18008 Granada, Spain.
    Hviid, H. S.
    Inst Planetenforsch, Deutsch Zentrum Luft & Raumfahrt DLR, Rutherfordstr 2, D-12489 Berlin, Germany.
    Ip, W. H.
    Natl Cent Univ, Grad Inst Astron, 300 Chung Da Rd, Chungli 32054, Taiwan;Macau Univ Sci & Technol, Space Sci Inst, Ave Wal Long, Taipa, Macao, Peoples R China.
    Jorda, L.
    Aix Marseille Univ, CNRS, LAM, UMR 7326, F-13388 Marseille, France.
    Keller, H. U.
    Inst Planetenforsch, Deutsch Zentrum Luft & Raumfahrt DLR, Rutherfordstr 2, D-12489 Berlin, Germany;Tech Univ Carolo Wilhelmina Braunschweig, Inst Geophys & Extraterr Phys, Mendelssohnstr 3, D-38106 Braunschweig, Germany.
    Knollenberg, J.
    Inst Planetenforsch, Deutsch Zentrum Luft & Raumfahrt DLR, Rutherfordstr 2, D-12489 Berlin, Germany.
    Kramm, J. R.
    Max Planck Inst Stromungsforsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany.
    Kuhrt, E.
    Inst Planetenforsch, Deutsch Zentrum Luft & Raumfahrt DLR, Rutherfordstr 2, D-12489 Berlin, Germany.
    Kuppers, M.
    ESA, European Space Astron Ctr, Operat Dept, POB 78, E-28691 Madrid, Spain.
    Lara, M. L.
    CSIC, Inst Astrofis Andalucia, E-18008 Granada, Spain.
    Lazzarin, M.
    Univ Padua, Dept Phys & Astron G Galilei, Vic Ossevatorio 3, I-35122 Padua, Italy.
    Lopez-Moreno, J. J.
    CSIC, Inst Astrofis Andalucia, E-18008 Granada, Spain.
    Shi, X.
    Max Planck Inst Stromungsforsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany.
    Thomas, N.
    Univ Bern, Phys Inst, Sidlerstr 5, CH-3012 Bern, Switzerland;Univ Bern, Ctr Space & Habitabil, CH-3012 Bern, Switzerland.
    Tubiana, C.
    Max Planck Inst Stromungsforsch, Justus von Liebig Weg 3, D-37077 Gottingen, Germany.
    The phase function and density of the dust observed at comet 67P/Churyumov-Gerasimenko2018Inngår i: Monthly notices of the Royal Astronomical Society, ISSN 0035-8711, E-ISSN 1365-2966, Vol. 476, nr 2, s. 2835-2839Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The OSIRIS camera onboard Rosetta measured the phase function of both the coma dust and the nucleus. The two functions have a very different slope versus the phase angle. Here, we show that the nucleus phase function should be adopted to convert the brightness to the size of dust particles larger than 2.5 mm only. This makes the dust bursts observed close to Rosetta by OSIRIS, occurring about every hour, consistent with the fragmentation on impact with Rosetta of parent particles, whose flux agrees with the dust flux observed by GIADA. OSIRIS also measured the antisunward acceleration of the fragments, thus providing the first direct measurement of the solar radiation force acting on the dust fragments and thus of their bulk density, excluding any measurable rocket effect by the ice sublimation from the dust. The obtained particle density distribution has a peak matching the bulk density of most COSIMA particles, and represents a subset of the density distribution measured by GIADA. This implies a bias in the elemental abundances measured by COSIMA, which thus are consistent with the 67P dust mass fractions inferred by GIADA, i.e. (38 +/- 8) per cent of hydrocarbons versus the (62 +/- 8) per cent of sulphides and silicates.

  • Janusek, D.
    et al.
    Polish Acad Sci, Nalecz Inst Biocybernet & Biomed Engn, Warsaw, Poland.
    Svehlikova, J.
    Slovak Acad Sci, Inst Measurement Sci, Bratislava, Slovakia.
    Zelinka, J.
    Slovak Acad Sci, Inst Measurement Sci, Bratislava, Slovakia.
    Weigl, Wojciech
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Zaczek, R.
    Med Univ Warsaw, Cent Clin Hosp, Dept Cardiol, Warsaw, Poland.
    Opolski, G.
    Med Univ Warsaw, Cent Clin Hosp, Dept Cardiol, Warsaw, Poland.
    Tysler, M.
    Slovak Acad Sci, Inst Measurement Sci, Bratislava, Slovakia.
    Maniewski, R.
    Polish Acad Sci, Nalecz Inst Biocybernet & Biomed Engn, Warsaw, Poland.
    The roles of mid-myocardial and epicardial cells in T-wave alternans development: a simulation study2018Inngår i: Biomedical engineering online, ISSN 1475-925X, E-ISSN 1475-925X, Vol. 17, artikkel-id 57Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The occurrence of T-wave alternans in electrocardiographic signals was recently linked to susceptibility to ventricular arrhythmias and sudden cardiac death. Thus, by detecting and comprehending the origins of T-wave alternans, it might be possible to prevent such events.

    Results: Here, we simulated T-wave alternans in a computer-generated human heart model by modulating the action potential duration and amplitude during the first part of the repolarization phase. We hypothesized that changes in the intracardiac alternans patterns of action potential properties would differentially influence T-wave alternans measurements at the body surface. Specifically, changes were simulated globally in the whole left and right ventricles to simulate concordant T-wave alternans, and locally in selected regions to simulate discordant and regional discordant, hereinafter referred to as “regional”, T-wave alternans. Body surface potential maps and 12-lead electrocardiographic signals were then computed. In depth discrimination, the influence of epicardial layers on T-wave alternans development was significantly higher than that of mid-myocardial cells. Meanwhile, spatial discrimination revealed that discordant and regional action potential property changes had a higher influence on T-wave alternans amplitude than concordant changes. Notably, varying T-wave alternans sources yielded distinct body surface potential map patterns for T-wave alternans amplitude, which can be used for location of regions within hearts exhibiting impaired repolarization. The highest ability for T-wave alternans detection was achieved in lead V1. Ultimately, we proposed new parameters Vector Magnitude Alternans and Vector Angle Alternans, with higher ability for T-wave alternans detection when using multi-lead electrocardiographic signals processing than for single leads. Finally, QT alternans was found to be associated with the process of T-wave alternans generation.

    Conclusions: The distributions of the body surface T-wave alternans amplitude have been shown to have unique patterns depending on the type of alternans (concordant, discordant or regional) and the location of the disturbance in the heart. The influence of epicardial cells on T-wave alternans development is significantly higher than that of mid-myocardial cells, among which the sub-endocardial layer exerted the highest influence. QT interval alternans is identified as a phenomenon that correlate with T-wave alternans.

  • Juvrud, Joshua
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Gredebäck, Gustaf
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Åhs, Fredrik
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Lerin, Nils
    Goodbye Kansas Studios, Uppsala, Sweden.
    Nyström, Pär
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Kastrati, Granit
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Rosén, Jörgen
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    The Immersive Virtual Reality Lab: Possibilities for Remote Experimental Manipulations of Autonomic Activity on a Large Scale2018Inngår i: Frontiers in Neuroscience, ISSN 1662-4548, E-ISSN 1662-453X, Vol. 12, artikkel-id 305Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    There is a need for large-scale remote data collection in a controlled environment, and the in-home availability of virtual reality (VR) and the commercial availability of eye tracking for VR present unique and exciting opportunities for researchers. We propose and provide a proof-of-concept assessment of a robust system for large-scale in-home testing using consumer products that combines psychophysiological measures and VR, here referred to as a Virtual Lab. For the first time, this method is validated by correlating autonomic responses, skin conductance response (SCR), and pupillary dilation, in response to a spider, a beetle, and a ball using commercially available VR. Participants demonstrated greater SCR and pupillary responses to the spider, and the effect was dependent on the proximity of the stimuli to the participant, with a stronger response when the spider was close to the virtual self. We replicated these effects across two experiments and in separate physical room contexts to mimic variability in home environment. Together, these findings demonstrate the utility of pupil dilation as a marker of autonomic arousal and the feasibility to assess this in commercially available VR hardware and support a robust Virtual Lab tool for massive remote testing.

  • Vega, Carmen
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Luft-, vatten och landskapslära. Norwegian Polar Res Inst, N-9296 Tromso, Norway;Univ Costa Rica, Sch Phys, San Jose 115012060, Costa Rica;Univ Costa Rica, Ctr Geophys Res, San Jose 115012060, Costa Rica.
    Isaksson, Elisabeth
    Norwegian Polar Res Inst, N-9296 Tromso, Norway.
    Schlosser, Elisabeth
    Univ Innsbruck, Inst Atmospher & Cryospher Sci, Innsbruck, Austria;Austrian Polar Res Inst, Vienna, Austria.
    Divine, Dmitry
    Norwegian Polar Res Inst, N-9296 Tromso, Norway.
    Martma, Tonu
    Tallinn Univ Technol, Dept Geol, Tallinn, Estonia.
    Mulvaney, Robert
    British Antarctic Survey, Madingley Rd, Cambridge CB3 0ET, Cambs, England.
    Eichler, Anja
    PSI, CH-5232 Villigen, Switzerland.
    Schwikowski-Gigar, Margit
    PSI, CH-5232 Villigen, Switzerland.
    Variability of sea salts in ice and firn cores from Fimbul Ice Shelf, Dronning Maud Land, Antarctica2018Inngår i: The Cryosphere, ISSN 1994-0416, E-ISSN 1994-0424, Vol. 12, nr 5, s. 1681-1697Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Major ions were analysed in firn and ice cores located at Fimbul Ice Shelf (FIS), Dronning Maud Land - DML, Antarctica. FIS is the largest ice shelf in the Haakon VII Sea, with an extent of approximately 36 500 km(2). Three shallow firn cores (about 20m deep) were retrieved in different ice rises, Kupol Ciolkovskogo (KC), Kupol Moskovskij (KM), and Blaskimen Island (BI), while a 100m long core (S100) was drilled near the FIS edge. These sites are distributed over the entire FIS area so that they provide a variety of elevation (50-400ma. s.l.) and distance (3-42 km) to the sea. Sea-salt species (mainly Na+ and Cl-) generally dominate the precipitation chemistry in the study region. We associate a significant sixfold increase in median sea-salt concentrations, observed in the S100 core after the 1950s, to an enhanced exposure of the S100 site to primary sea-salt aerosol due to a shorter distance from the S100 site to the ice front, and to enhanced sea-salt aerosol production from blowing salty snow over sea ice, most likely related to the calving of Trolltunga occurred during the 1960s. This increase in sea-salt concentrations is synchronous with a shift in non-seasalt sulfate (nssSO2 4) toward negative values, suggesting a possible contribution of fractionated aerosol to the sea-salt load in the S100 core most likely originating from salty snow found on sea ice. In contrast, there is no evidence of a significant contribution of fractionated sea salt to the ice-rises sites, where the signal would be most likely masked by the large inputs of biogenic sulfate estimated for these sites. In summary, these results suggest that the S100 core contains a sea-salt record dominated by the proximity of the site to the ocean, and processes of sea ice formation in the neighbouring waters. In contrast, the ice-rises firn cores register a larger-scale signal of atmospheric flow conditions and a less efficient transport of sea-salt aerosols to these sites. These findings are a contribution to the understanding of the mechanisms behind sea-salt aerosol production, transport and deposition at coastal Antarctic sites, and the improvement of the current Antarctic sea ice reconstructions based on sea-salt chemical proxies obtained from ice cores.

  • Otto, Marcia C. de Oliveira
    et al.
    Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA.
    Lemaitre, Rozenn N.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.
    Sun, Qi
    Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA .
    King, Irena B.
    Univ New Mexico, Albuquerque, NM USA.
    Wu, Jason H. Y.
    Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia; Univ New South Wales, Fac Med, Sydney, NSW, Australia.
    Manichaikul, Ani
    Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA.
    Rich, Stephen S.
    Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA.
    Tsai, Michael Y.
    Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN USA.
    Chen, Y. D.
    Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Los Angeles Biomed Res Inst, Torrance, CA USA.
    Fornage, Myriam
    Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Key Lab Nutr & Metab, Houston, TX USA.
    Weihua, Guan
    Univ Minnesota, Dept Biostat, Minneapolis, MN USA.
    Aslibekyan, Stella
    Univ Kentucky, Coll Publ Hlth, Lexington, KY USA.
    Irvin, Marguerite R.
    Univ Kentucky, Coll Publ Hlth, Lexington, KY USA.
    Kabagambe, Edmond K.
    Univ Kentucky, Coll Publ Hlth, Lexington, KY USA.
    Arnett, Donna K.
    Univ Kentucky, Coll Publ Hlth, Lexington, KY USA.
    Jensen, Majken K.
    Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA;Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Boston, MA USA.
    McKnight, Barbara
    Univ Washington, Dept Biostat, Seattle, WA USA.
    Psaty, Bruce M.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA; Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA.
    Steffen, Lyn M.
    Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
    Smith, Caren E.
    Tufts Univ, Jean Mayer USDA HNRCA, Nutr & Genom Lab, Boston, MA USA.
    Risérus, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Klinisk nutrition och metabolism.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Hu, Frank B.
    Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA.
    Rimm, Eric B.
    Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA.
    Siscovick, David S.
    New York Acad Med, New York, NY USA.
    Mozaffarian, Dariush
    Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA USA.
    Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium2018Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 5, artikkel-id e0196951Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Odd-numbered chain saturated fatty acids (OCSFA) have been associated with potential health benefits. Although some OCSFA (e.g., C15:0 and C17:0) are found in meats and dairy products, sources and metabolism of C19:0 and C23:0 are relatively unknown, and the influence of non-dietary determinants, including genetic factors, on circulating levels of OCSFA is not established.

    Objective: To elucidate the biological processes that influence circulating levels of OCSFA by investigating associations between genetic variation and OCSFA.

    Design: We performed a meta-analysis of genome-wide association studies (GWAS) of plasma phospholipid/erythrocyte levels of C15:0, C17:0, C19:0, and C23:0 among 11,494 individuals of European descent. We also investigated relationships between specific single nucleotide polymorphisms (SNPs) in the lactase (LCT) gene, associated with adult-onset lactase intolerance, with circulating levels of dairy-derived OCSFA, and evaluated associations of candidate sphingolipid genes with C23:0 levels.

    Results: We found no genome-wide significant evidence that common genetic variation is associated with circulating levels of C15:0 or C23:0. In two cohorts with available data, we identified one intronic SNP (rs13361131) in myosin X gene (MYO10) associated with C17:0 level (P = 1.37×10−8), and two intronic SNP (rs12874278 and rs17363566) in deleted in lymphocytic leukemia 1 (DLEU1) region associated with C19:0 level (P = 7.07×10−9). In contrast, when using a candidate-gene approach, we found evidence that three SNPs in LCT (rs11884924, rs16832067, and rs3816088) are associated with circulating C17:0 level (adjusted P = 4×10−2). In addition, nine SNPs in the ceramide synthase 4 (CERS4) region were associated with circulating C23:0 levels (adjusted P<5×10−2).

    Conclusions: Our findings suggest that circulating levels of OCSFA may be predominantly influenced by non-genetic factors. SNPs associated with C17:0 level in the LCT gene may reflect genetic influence in dairy consumption or in metabolism of dairy foods. SNPs associated with C23:0 may reflect a role of genetic factors in the synthesis of sphingomyelin.

  • Sellberg, Fanny
    et al.
    Karolinska Inst, Dept Publ Hlth Sci, Social Med, Stockholm, Sweden.
    Possmark, Sofie
    Karolinska Inst, Dept Publ Hlth Sci, Social Med, Stockholm, Sweden.
    Ghaderi, Ata
    Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
    Näslund, Erik
    Karolinska Inst, Danderyd Hosp, Div Clin Sci, Stockholm, Sweden.
    Willmer, Mikaela
    Univ Gävle, Dept Hlth & Caring Sci, Gävle, Sweden.
    Tynelius, Per
    Karolinska Inst, Dept Publ Hlth Sci, Social Med, Stockholm, Sweden; Stockholm Cty Council, Ctr Epidemiol & Community Med, Stockholm, Sweden.
    Thorell, Anders
    Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden; Ersta Hosp, Dept Surg, Stockholm, Sweden.
    Sundbom, Magnus
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Gastrointestinalkirurgi.
    Uddén, Joanna
    Karolinska Inst, Dept Med, Stockholm, Sweden; Capio St Gorans Hosp, Dept Endocrine & Obes, Stockholm, Sweden.
    Szabo, Eva
    Örebro Univ, Fac Med & Hlth, Dept Surg, Örebro, Sweden.
    Berglind, Daniel
    Karolinska Inst, Dept Publ Hlth Sci, Social Med, Stockholm, Sweden.
    A dissonance-based intervention for women post roux-en-Y gastric bypass surgery aiming at improving quality of life and physical activity 24 months after surgery: study protocol for a randomized controlled trial2018Inngår i: BMC Surgery, ISSN 1471-2482, E-ISSN 1471-2482, Vol. 18, nr 25Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Roux-en-Y gastric bypass (RYGB) surgery is the most common bariatric procedure in Sweden and results in substantial weight loss. Approximately one year post-surgery weight regain for these patient are common, followed by a decrease in health related quality of life (HRQoL) and physical activity (PA). Our aim is to investigate the effects of a dissonance-based intervention on HRQoL, PA and other health-related behaviors in female RYGB patients 24 months after surgery. We are not aware of any previous RCT that has investigated the effects of a similar intervention targeting health behaviors after RYGB.

    Methods: The ongoing RCT, the “WELL-GBP”-trial (wellbeing after gastric bypass), is a dissonance-based intervention for female RYGB patients conducted at five hospitals in Sweden. The participants are randomized to either control group receiving usual follow-up care, or to receive an intervention consisting of four group sessions three months post-surgery during which a modified version of the Stice dissonance-based intervention model is used. The sessions are held at the hospitals, and topics discussed are PA, eating behavior, social and intimate relationships. All participants are asked to complete questionnaires measuring HRQoL and other health-related behaviors and wear an accelerometer for seven days before surgery and at six months, one year and two years after surgery. The intention to treat and per protocol analysis will focus on differences between the intervention and control group from pre-surgery assessments to follow-up assessments at 24 months after RYGB. Patients’ baseline characteristics are presented in this protocol paper.

    Discussion: A total of 259 RYGB female patients has been enrolled in the “WELL-GBP”-trial, of which 156 women have been randomized to receive the intervention and 103 women to control group. The trial is conducted within a Swedish health care setting where female RYGB patients from diverse geographical areas are represented. Our results may, therefore, be representative for female RYGB patients in the country as a whole. If the intervention is effective, implementation within the Swedish health care system is possible within the near future.

    Trial registration: The trial was registered on February 23th 2015 with registration number ISRCTN16417174.

  • Nešić, Damir
    et al.
    KTH, Skolan för industriell teknik och management (ITM), Maskinkonstruktion (Inst.), Mekatronik.
    Nyberg, Mattias
    KTH, Skolan för industriell teknik och management (ITM), Maskinkonstruktion (Inst.), Mekatronik. Scania CV AB, Södertälje, Sweden.
    Contract-based Specification and Description-Logic-Based Validation of Product Lines2018Rapport (Annet vitenskapelig)
    Abstract [en]

    The complexity of critical systems is constantly increasing. Consequently, assuring properties like safety or security of such systems is increasingly difficult. The difficulties are only intensified in the Product-Line Engineering (PLE) context, where properties of a complete family of systems, i.e. a Product Line (PL), must be assured. Contract-Based Specification and Design (CBSD) paradigm is a promising approach for alleviating these difficulties because it is a general-purpose, formal paradigm, developed purposely to support structured development of complex systems which are correct-by-design. Starting from a general CBSD framework, we present an extension that supports using CBSD in PLE, and prove that the extension preserves the properties of the original framework. Then, as a step towards providing tool-support for CBSD specification of PLs, we define the encoding of an arbitrary CBSD model of a PL, together with the constraints which define a proper CBSD model, as a Tbox of a description logic knowledge base. Finally, we show how verification of these constraints can be reduced to satisfiability verification of the corresponding knowledge base. In order to validate the presented approach, a CBSD specification of a small, but real, industrial PL is created, implemented as an OWL ontology, and an off-the-shelf reasoner was used to verify if the provided CBSD model is proper.

  • Treverton, Gregory F.
    Försvarshögskolan, Institutionen för säkerhet, strategi och ledarskap (ISSL), Centrum för totalförsvar och samhällets säkerhet, CATS (Centrum för Asymmetriska Hot- och Terrorismstudier). RAND Corporation.
    New Frontiers in Intelligence: Notes from seminar in Stockholm May 27-28 20082008Konferanseproceedings (Annet vitenskapelig)
  • Ranstorp, Magnus
    et al.
    Försvarshögskolan, Institutionen för säkerhet, strategi och ledarskap (ISSL), Centrum för totalförsvar och samhällets säkerhet, CATS (Centrum för Asymmetriska Hot- och Terrorismstudier).
    Dos Santos, Josefine
    Hot mot demokrati och värdegrund - en lägesbild från Malmö2009Rapport (Annet vitenskapelig)
  • Thordardottir, Steinunn
    et al.
    Karolinska Inst, Ctr Alzheimer Res, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc, S-14157 Huddinge, Sweden;Karolinska Univ Hosp Huddinge, Theme Aging, S-14186 Stockholm, Sweden.
    Rodriguez-Vieitez, Elena
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Ctr Alzheimer Res, Div Translat Alzheimer Neurobiol, S-14157 Huddinge, Sweden.
    Almkvist, Ove
    Karolinska Univ Hosp Huddinge, Theme Aging, S-14186 Stockholm, Sweden;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Ctr Alzheimer Res, Div Translat Alzheimer Neurobiol, S-14157 Huddinge, Sweden;Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden.
    Ferreira, Daniel
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Ctr Alzheimer Res, Div Clin Geriatr, S-14157 Huddinge, Sweden.
    Saint-Aubert, Laure
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Ctr Alzheimer Res, Div Translat Alzheimer Neurobiol, S-14157 Huddinge, Sweden;Univ Toulouse, Toulouse NeuroImaging Ctr, INSERM, UPS, Toulouse, France.
    Kinhult-Stahlbom, Anne
    Karolinska Inst, Ctr Alzheimer Res, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc, S-14157 Huddinge, Sweden;Karolinska Univ Hosp Huddinge, Theme Aging, S-14186 Stockholm, Sweden.
    Thonberg, Hakan
    Karolinska Inst, Ctr Alzheimer Res, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc, S-14157 Huddinge, Sweden;Karolinska Univ Hosp Huddinge, Theme Aging, S-14186 Stockholm, Sweden.
    Scholl, Michael
    Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, S-41345 Gothenburg, Sweden;Univ Gothenburg, Dept Psychiat & Neurochem, S-41345 Gothenburg, Sweden;Lund Univ, Clin Memory Res Unit, S-21224 Malmo, Sweden.
    Westman, Eric
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Ctr Alzheimer Res, Div Clin Geriatr, S-14157 Huddinge, Sweden.
    Wall, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.
    Eriksdotte, Maria
    Karolinska Univ Hosp Huddinge, Theme Aging, S-14186 Stockholm, Sweden;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Ctr Alzheimer Res, Div Clin Geriatr, S-14157 Huddinge, Sweden.
    Zetterberg, Henrik
    Univ Gothenburg, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Sahlgrenska Acad, S-43180 Molndal, Sweden;UCL Inst Neurol, Queen Sq, London WC1N 3BG, England;UCL, UK Dementia Res Inst, London WC1N 3BG, England;Sahlgrens Univ Hosp, Clin Neurochem Lab, S-43180 Molndal, Sweden.
    Blennow, Kaj
    Univ Gothenburg, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Sahlgrenska Acad, S-43180 Molndal, Sweden;Sahlgrens Univ Hosp, Clin Neurochem Lab, S-43180 Molndal, Sweden.
    Nordberg, Agneta
    Karolinska Univ Hosp Huddinge, Theme Aging, S-14186 Stockholm, Sweden;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Ctr Alzheimer Res, Div Translat Alzheimer Neurobiol, S-14157 Huddinge, Sweden.
    Graff, Caroline
    Karolinska Inst, Ctr Alzheimer Res, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc, S-14157 Huddinge, Sweden;Karolinska Univ Hosp Huddinge, Theme Aging, S-14186 Stockholm, Sweden.
    Reduced penetrance of the PSEN1 H163Y autosomal dominant Alzheimer mutation: a 22-year follow-up study2018Inngår i: Alzheimer's Research & Therapy, ISSN 0065-6755, E-ISSN 1758-9193, Vol. 10, artikkel-id 45Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The range of onset ages within some PSEN1 families is wide, and a few cases of reduced penetrance of PSEN1 mutations have been reported. However, published data on reduced penetrance have been limited to clinical histories, often collected retrospectively and lacking biomarker information. We present a case of reduced penetrance of the PSEN1 H163Y mutation in a carrier prospectively followed for 22 years.

    Methods: Two brothers (A and B), both carriers of the H163Y mutation, were followed between 1995 and 2017. They underwent repeated clinical evaluations, neuropsychological assessments, and cerebrospinal fluid analyses, as well as brain imaging examinations with structural magnetic resonance, [18F]fluorodeoxyglucose positron emission tomography, and [11C]Pittsburgh compound B positron emission tomography.

    Results: Brother A was followed between 44 and 64 years of age. Cognitive symptoms due to Alzheimer’s disease set in at the age of 54. Gradual worsening of symptoms resulted in admittance to a nursing home owing to dependence on others for all activities of daily living. He showed a curvilinear decline in cognitive function on neuropsychological tests, and changes on magnetic resonance imaging, positron emission tomography, and biomarkers in the cerebrospinal fluid supported a clinical diagnosis of Alzheimer’s disease. Brother A died at the age of 64 and fulfilled the criteria for definitive Alzheimer’s disease according to neuropathological examination results. Brother B was followed between the ages of 43 and 65 and showed no cognitive deterioration on repeated neuropsychological test occasions. In addition, no biomarker evidence of Alzheimer’s disease pathology was detected, either on imaging examinations or in cerebrospinal fluid.

    Conclusions: The average (SD) age of symptom onset for PSEN1 H163Y is 51 ± 7 years according to previous studies. However, we present a case of a biomarker-verified reduction in penetrance in a mutation carrier who was still symptom-free at the age of 65. This suggests that other genetic, epigenetic, and/or environmental factors modify the onset age.

  • Wilhelmson, Nina
    et al.
    Försvarshögskolan, Institutionen för säkerhet, strategi och ledarskap (ISSL), Centrum för totalförsvar och samhällets säkerhet, CATS (Centrum för Asymmetriska Hot- och Terrorismstudier).
    Svensson, Thomas
    Försvarshögskolan, Institutionen för säkerhet, strategi och ledarskap (ISSL), Centrum för totalförsvar och samhällets säkerhet, CATS (Centrum för Asymmetriska Hot- och Terrorismstudier).
    Handbook for planning, running and evaluating information technology and cyber security exercises2011Bok (Annet vitenskapelig)
    Abstract [en]

    Cyber Defence Exercise (CDX) is a tool for raising cyber security awarenessand train people to handle different situations in a controlled cyberenvironment. To exercise is a way of enhancing Tools, Techniques andProcedures, TTP. It’s also a way of building trust between the participants,as cooperation is needed to solve problems under stress. Failuresgive lessons learned and not any drastic consequences.

    In this handbook by the Swedish National Defence College’s Centerfor Asymmetric Threat Studies (CATS), Nina Wilhelmson and ThomasSvensson describes different types of exercises and in particular Red versusBlue Team Exercise. It covers the process from the first idea to theafter action analysis. Thomas Svensson has been represented CATS inBaltic Cyber Shield 2010 and Locked Shields 2012 – 2014 as a memberof the exercise control team (White Team). The base for the handbookhas been Swedish Civil Contingencies Agency (MSB) ExerciseHandbook with additions and lessons learned from Cyber DefenceExercises held in cooperation between Sweden and Estonia.

  • Kuosa, Tuomo
    Towards Strategic Intelligence: Foresight, Intelligence, and Policy-Making2014Bok (Annet vitenskapelig)
    Abstract [en]

    Strategic intelligence deals with national or corporate long-term strategic issues. It operates simultaneously with three functionalities: intelligence, strategic foresight, and visionary management. Its customers are senior policy-makers in versatile organisations capable of strategically impacting the game in which they are involved.

    This book explores opportunities to enhance strategic intelligence capabil-ities especially in policy-making and helps to understand how the princi-ples of strategic intelligence could be utilised within the intelligence com-munity and its practices. In particular, the book attempts to answer “how we could bridge the gap between the prevailing theory of intelligence pro-cesses and its actual practice” and “how intelligence could better bring right-time data for policy-makers.” In addition, the book studies how fore-sight work could be developed towards strategic intelligence so that it would better serve both intelligence community and policy-making.

  • Treverton, Gregory F.
    et al.
    Försvarshögskolan, Institutionen för säkerhet, strategi och ledarskap (ISSL), Centrum för totalförsvar och samhällets säkerhet, CATS (Centrum för Asymmetriska Hot- och Terrorismstudier). RAND Corporation.
    Miles, Renanah
    Columbia University; RAND Corporation.
    Social Media and Intelligence2014Rapport (Annet vitenskapelig)
    Abstract [en]

    This paper is part of CATS’ project on intelligence for terrorismand homeland security, sponsored by the Swedish CivilContingencies Agency (MSB). It addresses the use and potentialuse of social media in intelligence – looking across the range ofpossible uses both externally and as collaborative tools within andacross agencies. The first half of the paper lays out four categoriesof intelligence interactions using social media, and then discussesthem briefly, drawing primarily on U.S. experiences. The secondpart of the paper turns more specifically to the mix of new mediaand old at play in conflicts around the world, especially in theMiddle East and Russia/Crimea/Ukraine.

    Gregory Treverton is chairman of the U.S. National IntelligenceCouncil. However, this paper was written when he was a Directorof the RAND Corporation’s Center for Global Risk and Security,and a visiting fellow at CATS.

    Renanah Miles is a Ph.D. candidate in Political Science atColumbia University and a summer associate at the RANDCorporation. She concentrates in international relations with afocus on security studies and the Middle East. Previously she wasa program analyst in the Office of the Secretary of Defense.

  • Saadatmand, Mehrdad
    et al.
    RISE - Research Institutes of Sweden, ICT, SICS.
    Hansson, Hans
    RISE - Research Institutes of Sweden, ICT, SICS. Mälardalen University.
    Thane, Henrik
    Safety Integrity AB.
    Hänninen, Kaj
    Mälardalen University.
    Inadequate Risk Analysis Might Jeopardize The Functional Safety of Modern Systems2016Rapport (Annet vitenskapelig)
    Abstract [en]

    In the early 90s, researchers began to focus on security as an important property to address in combination with safety. Over the years, researchers have proposed approaches to harmonize activities within the safety and security disciplines. Despite the academic efforts to identify interdependencies and to propose combined approaches for safety and security, there is still a lack of integration between safety and security practices in the industrial context, as they have separate standards and independent processes often addressed and assessed by different organizational teams and authorities. Specifically, security concerns are generally not covered in any detail in safety standards potentially resulting in successfully safety-certified systems that still are open for security threats from e.g., malicious intents from internal and external personnel and hackers that may jeopardize safety. In recent years security has again received an increasing attention of being an important issue also in safety assurance, as the open interconnected nature of emerging systems makes them susceptible to security threats at a much higher degree than existing more confined products.This article presents initial ideas on how to extend safety work to include aspects of security during the context establishment and initial risk assessment procedures. The ambition of our proposal is to improve safety and increase efficiency and effectiveness of the safety work within the frames of the current safety standards, i.e., raised security awareness in compliance with the current safety standards. We believe that our proposal is useful to raise the security awareness in industrial contexts, although it is not a complete harmonization of safety and security disciplines, as it merely provides applicable guidance to increase security awareness in a safety context.

  • Meleagrou-Hitchens, Alexander
    et al.
    International Centre for the Study of Radicalisation (ISCR), King's College, London.
    Brun, Hans
    International Centre for the Study of Radicalisation (ISCR), King's College, London.
    A Neo-Nationalist Network: The English Defence League and Europe’s Counter-Jihad Movement2013Rapport (Annet vitenskapelig)
  • Treverton, Gregory
    Försvarshögskolan, Institutionen för säkerhet, strategi och ledarskap (ISSL), Centrum för totalförsvar och samhällets säkerhet, CATS (Centrum för Asymmetriska Hot- och Terrorismstudier).
    Influence Operations and the Intelligence/Policy Challenges2017Rapport (Annet vitenskapelig)
    Abstract [en]

    This conference report aim to assess influence operations, especially those conducted by Russia, in the context of changing relations between intelligence and policy and the emerging challenges for intelligence. Three key challenges were discussed in regard to influence operations. First, Identify – how to separate state sponsored disinformation from individual rumor mills. Second, Understand – how to understand influence operations, put it into a context for policy makers, and learn to understand the underlying factors and why it happens. Third, Counter – how to vaccinate civil servants and enhance the critical approach within media to create resilience against influence operations.

    The first part of this conference report lays out on how to identify and understand influence operations in the context of policy. The second part focus on who needs what to counter influence operations. The last part contains concluding themes.

    Dr. Gregory Treverton is the former chairman of the U.S. National Intelligence Council, as well as former Director of the RAND Corporation’s Center for Global Risk and Security. Dr. Treverton is also a Senior Fellow at the Center for Asymmetric Threat Studies (CATS) at the Swedish Defence University.

  • Liljeruhm, Josefine
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylärbiologi.
    Funk, Saskia K.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi.
    Tietscher, Sandra
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi.
    Edlund, Anders D.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi. Uppsala Univ, iGEM Uppsala, Uppsala, Sweden.
    Jamal, Sabri
    Uppsala Univ, iGEM Uppsala, Uppsala, Sweden.
    Yuen, Pikkei
    Uppsala Univ, iGEM Uppsala, Uppsala, Sweden.
    Dyrhage, Karl
    Uppsala Univ, iGEM Uppsala, Uppsala, Sweden.
    Gynnå, Arvid H.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär systembiologi. Uppsala Univ, iGEM Uppsala, Uppsala, Sweden.
    Ivermark, Katarina
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för biologisk grundutbildning.
    Lövgren, Jessica
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för biologisk grundutbildning.
    Törnblom, Viktor
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för biologisk grundutbildning.
    Virtanen, Anders
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Mikrobiologi.
    Lundin, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala Univ, iGEM Uppsala, Uppsala, Sweden.
    Wistand-Yuen, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Forster, Anthony C.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylärbiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Engineering a palette of eukaryotic chromoproteins for bacterial synthetic biology2018Inngår i: Journal of Biological Engineering, ISSN 1754-1611, E-ISSN 1754-1611, Vol. 12, artikkel-id 8Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Coral reefs are colored by eukaryotic chromoproteins (CPs) that are homologous to green fluorescent protein. CPs differ from fluorescent proteins (FPs) by intensely absorbing visible light to give strong colors in ambient light. This endows CPs with certain advantages over FPs, such as instrument-free detection uncomplicated by ultra-violet light damage or background fluorescence, efficient Forster resonance energy transfer (FRET) quenching, and photoacoustic imaging. Thus, CPs have found utility as genetic markers and in teaching, and are attractive for potential cell biosensor applications in the field. Most near-term applications of CPs require expression in a different domain of life: bacteria. However, it is unclear which of the eukaryotic CP genes might be suitable and how best to assay them.

    Results: Here, taking advantage of codon optimization programs in 12 cases, we engineered 14 CP sequences (meffRed, eforRed, asPink, spisPink, scOrange, fwYellow, amilGFP, amajLime, cjBlue, mefiBlue, aeBlue, amilCP, tsPurple and gfasPurple) into a palette of Escherichia coil BioBrick plasmids. BioBricks comply with synthetic biology's most widely used, simplified, cloning standard. Differences in color intensities, maturation times and fitness costs of expression were compared under the same conditions, and visible readout of gene expression was quantitated. A surprisingly large variation in cellular fitness costs was found, resulting in loss of color in some overnight liquid cultures of certain high-copy-plasmid-borne CPs, and cautioning the use of multiple CPs as markers in competition assays. We solved these two problems by integrating pairs of these genes into the chromosome and by engineering versions of the same CP with very different colors.

    Conclusion: Availability of 14 engineered CP genes compared in E coil, together with chromosomal mutants suitable for competition assays, should simplify and expand CP study and applications. There was no single plasmid-borne CP that combined all of the most desirable features of intense color, fast maturation and low fitness cost, so this study should help direct future engineering efforts.

  • Aspers, Patrik
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Sociologiska institutionen.
    Comment on ‘The Complex Market: Communications of Exchange, ObservingCompetitors, and Prices’ by Pascal Goeke and Evelyn Moser2018Inngår i: Sociologica, International Journal for Sociological Debate, ISSN 1971-8853, Vol. 12, nr 1, s. 101-104Artikkel i tidsskrift (Fagfellevurdert)
  • Almeida, Diogo
    et al.
    KTH, Skolan för datavetenskap och kommunikation (CSC), Robotik, perception och lärande, RPL. KTH.
    Karayiannidis, Yiannis
    KTH, Skolan för datavetenskap och kommunikation (CSC), Robotik, perception och lärande, RPL. Dept. of Electrical Eng., Chalmers University of Technology.
    A Framework for Bimanual Folding Assembly Under Uncertainties2017Inngår i: Workshop – Towards robust grasping and manipulation skills for humanoids, 2017Konferansepaper (Annet vitenskapelig)
  • Aaboud, M. y
    et al.
    Univ Mohamed Premier, Fac Sci, Oujda, Morocco;LPTPM, Oujda, Morocco.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik. Georg August Univ, Phys Inst 2, Gottingen, Germany.
    Brenner, Richard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Öhman, Henrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Woods, N.
    Univ Wisconsin Madison, Madison, WI USA.
    Combination of inclusive and differential t(t)over-bar charge asymmetry measurements using ATLAS and CMS data at root S =7 and 8 TeV2018Inngår i: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, nr 4, artikkel-id 033Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This paper presents combinations of inclusive and differential measurements of the charge asymmetry (A(C)) in top quark pair (t(t)over-bar) events with a lepton+jets signature by the ATLAS and CMS Collaborations, using data from LHC proton-proton collisions at centre-of-mass energies of 7 and 8 TeV. The data correspond to integrated luminosities of about 5 and 20 fb(-1) for each experiment, respectively. The resulting combined LHC measurements of the inclusive charge asymmetry are A(C)(LHC7) = 0.005 +/- 0.007 (stat) +/- 0.006 (syst) at 7 TeV and A(C)(LHC8) = 0.0055 +/- 0.0023 (stat) +/- 0.0025 (syst) at 8 TeV. These values, as well as the combination of A(C )measurements as a function of the invariant mass of the t(t)over-bar system at 8 TeV, are consistent with the respective standard model predictions.

  • Almandoz-Gil, Leire
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Welander, Hedvig
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Ihse, Elisabet
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Khoonsari, Payam Emami
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Cancerfarmakologi och beräkningsmedicin.
    Musunuri, Sravani
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Lendel, Christofer
    KTH Royal Inst Technol, Dept Chem, Stockholm, Sweden.
    Sigvardson, Jessica
    BioArctic AB, Stockholm, Sweden.
    Karlsson, Mikael
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Ingelsson, Martin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Kultima, Kim
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Cancerfarmakologi och beräkningsmedicin.
    Bergström, Joakim
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Corrigendum to “Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways” [Free Rad. Biol. Med. (2017) 421–431]2018Inngår i: Free Radical Biology & Medicine, ISSN 0891-5849, E-ISSN 1873-4596, Vol. 117, s. 258-258Artikkel i tidsskrift (Annet vitenskapelig)
  • Jinzhi, Lu
    et al.
    KTH, Skolan för industriell teknik och management (ITM). KTH-Royal Insititute of Technology.
    Jian, Wang
    University of Electronic Science and Technology of China,.
    Zhe, Chen
    University of Electronic Science and Technology of China,.
    A Fault Propagation Model for FPGA Netlist with Un-reconvergence Paths2018Inngår i: 2018 5th International Conference on Information Science and Control Engineering / [ed] IEEE, 2018Konferansepaper (Fagfellevurdert)
  • Trubetskaya, Anna
    et al.
    Mechanical Engineering Department, National University of Ireland Galway.
    Hofmann Larsen, Flemming
    Department of Food Science, University of Copenhagen.
    Shchukarev, Andrey
    Department of Chemistry, Umeå University.
    Ståhl, Kenny
    Department of Chemistry, Technical University of Denmark.
    Umeki, Kentaro
    Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, Energivetenskap.
    Potassium and soot interaction in fast biomass pyrolysis at high temperatures2018Konferansepaper (Fagfellevurdert)