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  • Concept for joint Nordic cultural initiatives outside the Nordic region2018Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    During the Danish presidency of the Nordic Council of Ministers in 2015, a Nordic working group developed a concept for joint Nordic cultural initiatives outside the Nordic region. The concept was approved by the Nordic ministers for culture in 2015, and was tested in conjunction with the Nordic Matters event in London in 2017. On the basis of the experiences of using the concept with Nordic Matters, the concept was revised by the Nordic ministers for culture on 31 October 2018.

  • Janson, Christer
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Johannessen, Ane
    Haukeland Hosp, Ctr Clin Res, Bergen, Norway.
    Franklin, Karl
    Umea Univ, Dept Surg & Perioperat Sci, Surg, Umea, Sweden.
    Svanes, Cecilie
    Univ Bergen, Inst Clin Sci, Bergen, Norway.
    Schioler, Linus
    Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.
    Malinovschi, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk fysiologi.
    Gislason, Thorarinn
    Natl Univ Hosp Iceland, Dept Resp Med & Sleep, Reykjavik, Iceland;Univ Iceland, Fac Med, Reykjavik, Iceland.
    Benediktsdottir, Bryndis
    Natl Univ Hosp Iceland, Dept Resp Med & Sleep, Reykjavik, Iceland;Univ Iceland, Fac Med, Reykjavik, Iceland.
    Schlunssen, Vivi
    Aarhus Univ, Dept Publ Hlth, Sect Environm Occupat & Hlth, Aarhus, Denmark;Natl Res Ctr Working Environm, Copenhagen, Denmark.
    Jogi, Rain
    Tartu Univ Clin, Lung Clin, Tartu, Estonia.
    Jarvis, Deborah
    Imperial Coll, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London, England.
    Lindberg, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Change in the prevalence asthma, rhinitis and respiratory symptom over a 20 year period: associations to year of birth, life style and sleep related symptoms2018Inngår i: BMC Pulmonary Medicine, ISSN 1471-2466, E-ISSN 1471-2466, Vol. 18, artikkel-id 152Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The aim of this investigation was to study change in adults over a 20 year period in the prevalence of respiratory symptoms and disorders and its association to year of birth, life style and sleep related variables.

    Method: Adults 20-44 years of age, 6085 women and 5184 men, were randomly selected from seven centres in Northern Europe and followed for 20 years. The number of participants in the first survey was 21,595 and 11,269 participated in all three surveys. The participants were divided into three birth cohorts: 1944-1955, 1956-1965 and 1966-1975.

    Results: During the 20 year period the prevalence of wheeze decreased (-2%) and the prevalence of asthma (+ 4%) and allergic rhinitis (+ 5%) increased, whereas the prevalence of nocturnal respiratory symptoms was relatively unchanged. The increase in allergic rhinitis was largest in those born 1966 to 1975 except in Estonia. There was large decrease in smoking (-20%), increase in obesity (+ 7%) and snoring (+ 6%) during the study period. Smoking, obesity, snoring and nocturnal gastroesophageal reflux (nGER) were related to a higher risk of all symptoms. Obesity, snoring and nGER were also independently related to asthma.

    Conclusion: We conclude that as our participants got older there was a decrease in wheeze, no change in nocturnal symptoms and an increase in reported asthma and allergic rhinitis. These changes in prevalence are probably related to a decrease in smoking being counteracted by an increase in allergy, obesity and sleep related disorders.

  • Disputas: 2018-12-07 09:15 A1:107A, Uppsala
    Roos, Carl
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaci.
    Intestinal absorption of drugs: The impact of regional permeability, nanoparticles, and absorption-modifying excipients2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    For successful delivery of orally given drug products, the drug compounds must have adequate solubility and permeability in the human gastrointestinal tract. The permeability of a compound is determined by its size and lipophilicity, and is usually evaluated in various pre-clinical models, including rat models.

    This thesis had three major aims: 1) investigate regional permeability in human and rat intestines and evaluate two different rat models, 2) investigate the mechanisms behind absorption in nanosuspensions, and 3) investigate the effect of food on the absorption of drug molecules in solutions and suspensions, and also food’s effect on absorption modifying excipients (AMEs).

    Effective human permeability values obtained using regional intra-intestinal dosing and a deconvolution method agreed with values established by perfusion from the jejunum, demonstrating the accuracy and validity of the intra-intestinal bolus-dosing approach. Single-pass intestinal perfusion (SPIP) in rats showed better correlation with human effective permeability than the Ussing chamber, and was therefore deemed the better model for predicting drug permeability in humans.

    Absorption of microsuspensions and nanosuspension was investigated using rat SPIP, which showed that microsuspensions are subject to pronounced food effects, probably by partitioning of drug into the colloidal structures formed by bile acids, lecithin, and fatty acids. Nanosuspensions were less affected by food, which was attributed to fewer available nanoparticles in the fed state due to partitioning into colloidal structures, and because nanoparticles are able to cross the aqueous boundary layer on their own, increasing the concentration of drug adjacent to the epithelial membrane.

    AMEs had less effect in the fed state than the fasted state when investigated using SPIP. This difference may be caused by AMEs partitioning into luminal colloidal structures, decreasing the AMEs’ effects on the intestinal membrane. It thus seems that AMEs as well as drug compounds are subject to food-drug interactions, which may either increase or decrease the effect or absorption, something that needs to be considered during development of new drug products. 

    In summary, this thesis has improved the knowledge of pre-clinical absorption models and the understanding of several biopharmaceutical mechanisms important for drug absorption.

  • Koncept för samnordiska kultursatsningar utanför Norden2018Annet (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Inom ramen för det danska ordförandeskapet i Nordiska ministerrådet 2015 utarbetade en nordisk arbetsgrupp ett koncept för samnordiska kultursatsningar utanför Norden. Konceptet godkändes av de nordiska kulturministrarna 2015 och prövades i praktiken genom satsningen Nordic Matters i London 2017. Utifrån erfarenheterna med Nordic Matters reviderades konceptet av de nordiska kulturministrarna den 31 oktober 2018.

  • Disputas: 2018-12-05 13:00 Enghoff-salen, Uppsala
    Mörtsell, David
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi-arrytmi.
    Outcomes and safety of new techniques for pulmonary vein isolation in patients with paroxysmal and persistent atrial fibrillation: A study based on randomised trials and registries2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Atrial fibrillation (AF) is a common disease with a high prevalence in the adult population. Treatment of AF encompasses antiarrhythmic drugs and catheter ablation to reduce symptoms. The aim of this thesis was to study how to best alleviate symptoms of AF in a safe and efficient way comparing pharmacological treatment and the two dominating catheter ablation techniques, cryoballoon (CRYO) ablation and point-by-point radiofrequency (RF) ablation.

    Quality of life improved more for those AF patients randomised to treatment with catheter ablation compared to those treated with antiarrhythmic medication after 12 months of follow up (n=155).

    We evaluated a proposed optimised CRYO ablation protocol and randomised 140 patients to a single cryoballoon application per vein guided by a mapping catheter (Single cryo) or two cryoballoon applications (Routine). Acute pulmonary vein isolation rate did not differ. Procedure time decreased by 19 minutes with a lower complication rate in the Single cryo-arm. Freedom from AF after one procedure at 12 months did not differ; 73.9.0% (Single cryo) versus 71.4% (Routine).

    CRYO ablation was also assessed in persistent AF and paroxysmal AF. Freedom from arrhythmia recurrence was lower after a single ablation in persistent AF (64.9%) compared with paroxysmal AF (82.2%) after 12 months. However, the reduction of AF symptoms and quality of life was excellent in both groups and did not differ after 12 months.

    Patients undergoing their first AF ablation with CRYO or RF were included in a registry study. After 12 months, freedom from AF was equal irrespective of AF type, but there was a lower re-ablation rate and need for continued antiarrhythmic drug treatment after CRYO ablation. Procedure duration was reduced by 40 minutes with CRYO and complication rates did not differ,

    In conclusion, catheter ablation reduces AF symptoms more than antiarrhythmic drugs and cryoballoon ablation can be further optimised with reduced procedure times and improved safety. Cryoballoon ablation is as efficacious as RF ablation as a first-line therapy in both paroxysmal and persistent AF and the lower re-ablation rates and  shorter procedure times may have important clinical implications when choosing AF ablation technique.

  • Disputas: 2018-12-07 10:00 V159, Kalmar
    Rahmqvist Linnarsson, Josefin
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för hälso- och vårdvetenskap (HV).
    Forensic care for victims of violence and their family members in the emergency department2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Aim: To explore forensic care in EDs for victims of violence and their family members from the perspectives of ED department heads, ED nurses, and a family member of a victim of violence.

    Methods: Study I consisted of a questionnaire to all heads of EDs in Sweden, data were analyzed with descriptive statistics. Study II consisted of a similar questionnaire which also included the instrument Families’ Importance in Nursing Care-Nurses’ Attitudes. It was sent to all nurses at 28 EDs and data were analyzed using descriptive statistics, multiple linear and ordinal regression analysis. Study III comprised of individual interviews with twelve nurses from seven EDs and data were analyzed with content analysis. Study IV was a single case study with two interviews with a family member of a victim of violence. Data were analyzed with a Gadamer-inspired hermeneutic approach.

    Results: ED preparedness for forensic care varied and was often limited to women and children. Nurses played a key role, but most of them had no training for this task and felt uncertain (I, II, III). Creating a caring encounter was the main challenge for providing forensic care and nurses perceived hindering factors to overcome this challenge (III). Family members were rarely included in forensic care and nurses perceived that family members were offered little help (I-III). Having ED documents that included family members, was associated with a more positive attitude to family members, which in turn was associated with involving them in care (II). For the family member, perfunctory encounters and caring alliances had a major impact and the experience reframed life (IV).

    Conclusion: Lack of preparedness in EDs to care for all types of victims of violence and differences between individual nurses may prohibit the provision of equal care. Hindering factors for a caring encounter can result in forensic care being unaddressed, which may limit possibilities for alleviated suffering and legal justice. Family members were rarely included in forensic care, but caring encounters can be crucial for the family member in the aftermath of violence.

  • Englund Dimitrova, Birgitta
    Stockholms universitet, Humanistiska fakulteten, Institutionen för svenska och flerspråkighet, Tolk- och översättarinstitutet.
    Changing Footings on 'Jacob's Ladder': dealing with sensitive issues in dual-role mediation on a Swedish TV-show2018Inngår i: Perspectives: studies in translatology, ISSN 0907-676X, E-ISSN 1747-6623Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This case study examines a Swedish TV interview with a Soviet pop singer in 1985 where the talk show host, who is both a trained interpreter and an experienced media journalist, acts as a dual-role mediator, interviewing and interpreting at the same time. The analysis is contextualized within the political and military relations between Sweden and the USSR in the 1980s. Theoretically, the study draws on ethics of interpreting, ethics of entertainment and the notions participation status or footing. A potential challenge for a dual-role mediator is that two different ethical stances are involved; here, ethics of entertainment (entertainment, comfort, culture value orientation) and ethics of interpreting (impartiality, neutrality, accuracy). These may clash, but the study claims that the different stances can also be used to the participants’ advantage. Here, the role of talk show host dominates over the role of interpreter, and interpreting ethics can be flouted and played with if it suits the purposes of the former. The study shows the complexity of dual-role mediation and emphasizes the need to take into account the perspectives of both of the involved roles in research on participants’ interaction and changes of footing.

  • Disputas: 2018-12-07 09:15 Vivi Täckholmsalen (Q-salen), NPQ-huset, Stockholm
    Gañez Zapater, Antoni
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut.
    Gene regulation by chromatin remodelling complexes: SWI/SNF complex in mRNA processing and B-WICH complex in ribosomal gene expression2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The aim of this project is to investigate the roles of chromatin remodelling complexes in gene regulation. It is focused on two groups of chromatin complexes: the mammalian BRG1 and BRM SWI/SNF complexes and the ISWI-containing B-WICH complex.

    Study 1 investigates the role of SWI/SNF complexes in alternative splicing. We show that the presence of the ATPase core subunits Brg1 and Brm influence the alternative splicing outcome of a subset of genes. We show that Brg1 and Brm interact with several splicing related factors in the nascent RNA, and that the recruitment of some of these factors to their target sites is regulated by the presence of Brg1 and Brm. We propose that SWI/SNF ATPases can modulate the interactions of RNA binding factors to the nascent RNA and in that way alter alternative splicing outcome.

    Study 2 focuses on SWI/SNF complexes and their influence on cleavage and polyadenylation of mRNA. We show that Brg1 and Brm interact with subunits of the cleavage and polyadenylation complexes in the nascent mRNA. SWI/SNF complexes facilitate the recruitment of the cleavage and polyadenylation complex to the polyadenylation site in a subset of genes, and this results in a more efficient cleavage and polyadenylation.

    Study 3 shows that B-WICH is required for ribosome gene transcriptional activation upon glucose stimulation. WSTF and SNF2h, two of the B-WICH subunits, are needed to establish an active chromatin state in the RNA pol I gene promoter when the glucose concentration is raised after a period of deprivation. We propose that it counteracts the silent, poised chromatin state imposed by the silencing chromatin remodelling complex NuRD to allow for the RNA pol I machinery to bind to the promoter.

    These studies show that the influence of chromatin remodelling complexes upon gene expression is important for remodelling nucleosomes at the promoter, for alternative splicing, cleavage and polyadenylation and transcriptional initiation. These complexes work together with other chromatin remodelling factors, interact with other complexes and regulate their activity by affecting their recruitment dynamics.

  • Disputas: 2018-12-07 13:00 Nordenskiöldsalen, Geovetenskapens hus, Stockholm
    Grunditz, Sofia
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Barn- och ungdomsvetenskapliga institutionen.
    Vilan i förskolan 1910-2013: Visuella material och visuell metodologi2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The aim of this thesis is to explore preschool naptime during the period 1910–2013 through visual materials, films and photographs produced by different actors for various purposes at various historical times, and to develop a visual methodology that works with complex visual materials. Even though naptime is central to everyday life in preschool, it is an activity that is rarely a focus of Early Childhood Education research.  

    The empirical data derives from two separate but interrelated studies, the first a video ethnographic field study and the second an archival ethnographic study. Both studies include films and photographs that visualise the material environments and social interactions that take place during preschool naptime.

    A theoretical framework based on ethnomethodology, visual studies, childhood studies and the history of childhood studies is used. The concept the look of is a theoretical and analytical focus as the photographic image contains visual information about what things and actions look like. The look of children’s and adults’ participation in naptime, the material objects and the preschool environment are the focus when scrutinising the visual data of the study to gain knowledge about how embodied actions, along with the material and spatial design of the preschool environment, form practices at naptime. The thesis takes a post-positivist stance towards the photographic image.

    A transdisciplinary methodology, the visual remake, is developed for visual analysis and is used as a tool for comparisons, visualisation of results and reflection. A visual remake maintains the visual aspects of the data in order to keep them visible throughout the research process. It is a tool that visualises observable findings and conceptualises a reflection process through images, and not exclusively via the written word.

    The study provides knowledge about everyday life in preschool. The results show how the material and spatial organisation of the room and the participants’ embodied actions in this environment constitute naptime in both historical and contemporary preschools. There are recurrent patterns in the social interaction, as well as similarities in the design of the environment that are stable over time. These are the ways in which the participants use their bodies and interact through embodied interactions. The comparative visual analyses, focusing on continuity and change, suggest that some of these practices can be theorised as path-dependent. The present-day study shows that children constitute a peer culture within naptime, often through secondary adjustments to institutional and adult-structured order. Although the ideal naptime is visualised in the historical materials, it is possible to trace the same sort of naptime peer culture. There are features in the design of the beds used during preschool naptime that are typical of the preschool institution, and this design and the overall organisation of naptime have a path-dependence to ideals in the half-day preschools.

    Methodologically, the thesis expands our knowledge of how different visual materials can serve as sources in ECE research and how a research design focusing on the comparison of present-day and historical data opens up space for new research questions.

  • Disputas: 2018-12-08 10:00 hörsal 7, Stockholm
    Lidén, Johanna
    Stockholms universitet, Humanistiska fakulteten, Institutionen för etnologi, religionshistoria och genusvetenskap.
    The Taizhou Movement: Being Mindful in Sixteenth Century China2018Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    The aim of this thesis is to define and analyze the religious ideas, praxis and organizations of the Taizhou movement using the earliest sources from the Ming dynasty. The Taizhou movement originated with a salt merchant named Wang Gen (1483–1541), who became a disciple of the well-known Neo-Confucian philosopher Wang Yangming (1472–1529). Wang Gen’s thoughts were similar to his, but Wang Gen’s ideas about protecting and respecting the self were new. These ideas and the pursuit of making one’s mind calm inspired his followers who, like Wang Gen, tried to put them into practice. The thesis contextualizes Wang Gen and some of his followers who where active in the sixteenth century such as Yan Jun, Luo Rufang and He Xinyin. It contains texts which have not been translated into English before.

    Contrary to previous research, the thesis proposes that the Taizhou practitioners did not form a “school” in the strict sense of the word but became a “movement”. The reason was that their ideas corresponded to the anxieties and concerns of people from all levels of society and that they engaged in social and religious activities on the local level. Their ideas and praxis are heterogeneous, a result of the free discussions that were held in private academies. The religious praxis of the Taizhou movement included singing, reciting, individual and communal meditation, discussions and ethical commitments. Another claim of the thesis is that the Taizhou practitioners did not regard meditation in isolation as contradictory to social activism but as two complementary pursuits. Furthermore, the thesis argues that Huang Zongxi’s criticism of Wang Gen for adding Chan Buddhism to the philosophy of Wang Yangming was reasonable, contrary to what some researchers claim, but that the problem with his criticism is that it pertains to Wang Yangming himself as well.

    The demarcation lines between Confucianism, Buddhism and Daoism as well as those between “schools” within each tradition were porous, which is exemplified by the Taizhou practitioners. Sometimes they manifest Buddhist and Daoist influences, but their framework is Confucian. In general, they were not concerned with which tradition they belonged to but with transforming the individual and society. The Taizhou practitioners did not worship any Buddhist or Daoist deities, but they were engaged in reaching a specific state of mind and rendering the secular world sacred. Awakened understanding should be experienced personally. The Taizhou practitioners can be regarded as ‘religious’ using definitions of religion which affirm such experiential aspects, but their movement cannot be defined as a religion if the definition requires an institution. Officials and literati scholars criticized the Taizhou practitioners and some of them were persecuted. Luo Rufang experienced administrative persecution; Yan Jun was imprisoned for a period; He Xinyin was killed in prison in 1579, the same year as the Grand Secretary Zhang Juzheng prohibited free discussions in the private academies. The thesis claims that it was their ideas and actions perceived as dangerous to men of power which resulted in their persecution. The fact of belonging to a certain social segment had less importance.

  • Huq, Asif
    et al.
    Högskolan Dalarna, Mikrodataanalys.
    Hartwig, Fredrik
    Högskolan Dalarna, Företagsekonomi.
    Rudholm, Niklas
    HUI Research.
    Do audited firms have lower cost of debt?2018Rapport (Annet vitenskapelig)
    Abstract [en]

    The purpose of this study is to investigate if audited financial statements add value for firms in the private debt market. Using an instrumental variable method, we find that firms with audited financial statements, on average, save 1.26 percentage points on cost of debt compared to firms with unaudited financial statements. We also find that using the big, well-known auditing firms does not yield additional cost of debt benefits. Lastly, we find that the effect of audit on cost of debt varies between industries. As such, we find that firms in industries that have been identified in previous studies to have a more complex information structure, and therefore more complex auditing process, also save more on cost of debt relative to other industries when audited.

  • Adetula, Victor
    et al.
    Nordiska Afrikainstitutet, Research Unit.
    Murithi, Tim
    Institute for Justice and Reconciliation, Cape Town, South Africa.
    Buchanan-Clarke, Stephen
    Institute for Justice and Reconciliation, Cape Town, South Africa.
    Peace negotiations and agreements in Africa: why they fail and how to improve them2018Rapport (Annet vitenskapelig)
    Abstract [en]

    Peace is not just the absence of conflict. The self-interest lying behind external ‘support’ can take many shapes. The pursuit of justice can sometimes thwart peace efforts. And, last but not least, simply adding more women to peace negotiations will not break male-centric norms.

  • Thunberg, Sara ()
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Uhnoo, Daniel ()
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Bruhn, Anders ()
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Nationell forskningskonferens i socialt arbete: Abstractsammanställning2018Rapport (Annet vitenskapelig)
  • Bjarnesen, Jesper
    et al.
    Nordiska Afrikainstitutet, Research Unit.
    Söderberg Kovacs, Mimmi
    Folke Bernadotteakademin.
    Violence in African elections2018Rapport (Annet vitenskapelig)
    Abstract [en]

    The benefits of winning elections, and the disadvantages of losing them, must be reduced to avoid the violence that a winner-takes-all situation can trigger. Election observers should pay more attention to subtle forms of violence, intra-party tensions and incumbents playing the security card to justify increased use of force. This policy note considers how to curb the increase of violence in African elections.

  • Aaboud, M.
    et al.
    Univ Mohamed Premier & LPTPM, Fac Sci, Oujda, Morocco.
    Bergeås Kuutmann, Elin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Bokan, Petar
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik. Georg August Univ, Phys Inst II, Gottingen, Germany.
    Brenner, Richard
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ekelöf, Tord
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ellert, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Ferrari, Arnaud
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Gradin, P. O. Joakim
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Isacson, Max
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Mårtensson, Mikael
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Öhman, Henrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Rangel Smith, Camila
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Sales De Bruin, Pedro
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Högenergifysik.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    Search for supersymmetry in events with four or more leptons in root s=13 TeV pp collisions with ATLAS2018Inngår i: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 98, nr 3, artikkel-id 032009Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Results from a search for supersymmetry in events with four or more charged leptons (electrons, muons and taus) are presented. The analysis uses a data sample corresponding to 36.1 fb(-1) of proton-proton collisions delivered by the Large Hadron Collider at root s = 13 TeV and recorded by the ATLAS detector. Four-lepton signal regions with up to two hadronically decaying taus are designed to target a range of supersymmetric scenarios that can be either enriched in or depleted of events involving the production and decay of a Z boson. Data yields are consistent with Standard Model expectations and results are used to set upper limits on the event yields from processes beyond the Standard Model. Exclusion limits are set at the 95% confidence level in simplified models of general gauge mediated supersymmetry, where Higgsino masses are excluded up to 295 GeV. In R-parity-violating simplified models with decays of the lightest supersymmetric particle to charged leptons, lower limits of 1.46, 1.06, and 2.25 TeV are placed on wino, slepton and gluino masses, respectively.

  • Santiago-Kern, Rocio
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Gajewski, Konrad
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Hermansson, Lars
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Jobs, Magnus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Li, Han
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Lofnes, Tor
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Ruber, Roger
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Cryogenic Synopsis from the Testing of the Fully Equipped ESS' High Beta Cavity ESS086-P01 (Part II)2018Rapport (Annet vitenskapelig)
  • Santiago-Kern, Rocio
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Eriksson, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Hermansson, Lars
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Jönsson, Åke
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Cryogenic Settings for Testing of the Fully Equipped ESS' High Beta Cavity ESS086-P01 (Part II)2018Rapport (Annet vitenskapelig)
  • Santiago-Kern, Rocio
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Gajewski, Konrad
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Hermansson, Lars
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Jobs, Magnus
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Li, Han
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Lofnes, Tor
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Ruber, Roger
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Cryogenic Synopsis from the Testing of the Fully Equipped ESS' High Beta Cavity ESS086-P01 (Part I)2018Rapport (Annet vitenskapelig)
  • Santiago-Kern, Rocio
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Eriksson, Johan
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Hermansson, Lars
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Jönsson, Åke
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, FREIA.
    Cryogenic Settings for Testing of the Fully Equipped ESS' High Beta Cavity ESS086-P01 (Part I)2018Rapport (Annet vitenskapelig)
  • Kaden, Rene
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk mikrobiologi. National Veterinary Institute, Uppsala, Sweden; Swedish Forum for Biopreparedness Diagnostics, Umeå, Uppsala and Solna, Sweden; Swedish Joint Laboratory for Food Safety and Biopreparedness, Uppsala, Sweden.
    Ferrari, Sevinc
    National Veterinary Institute, Uppsala, Sweden; Swedish Forum for Biopreparedness Diagnostics, Umeå, Uppsala and Solna, Sweden; Swedish Joint Laboratory for Food Safety and Biopreparedness, Uppsala, Sweden.
    Jinnerot, Tomas
    National Veterinary Institute, Uppsala, Sweden; Swedish Forum for Biopreparedness Diagnostics, Umeå, Uppsala and Solna, Sweden; Swedish Joint Laboratory for Food Safety and Biopreparedness, Uppsala, Sweden.
    Lindberg, Martina
    National Veterinary Institute, Uppsala, Sweden; Swedish Forum for Biopreparedness Diagnostics, Umeå, Uppsala and Solna, Sweden; Swedish Joint Laboratory for Food Safety and Biopreparedness, Uppsala, Sweden; National Food Agency, Uppsala, Sweden.
    Wahab, Tara
    Swedish Forum for Biopreparedness Diagnostics, Umeå, Uppsala and Solna, Sweden; Public Health Agency of Sweden Solna, Sweden..
    Lavander, Moa
    Swedish Forum for Biopreparedness Diagnostics, Umeå, Uppsala and Solna, Sweden; Swedish Joint Laboratory for Food Safety and Biopreparedness, Uppsala, Sweden; National Food Agency, Uppsala, Sweden..
    Brucella abortus: determination of survival times and evaluation of methods for detection in several matrices2018Inngår i: BMC Infectious Diseases, ISSN 1471-2334, E-ISSN 1471-2334, Vol. 18, artikkel-id 259Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Brucella abortus is a highly pathogenic zoonotic agent, tempting for the development of a rapid diagnostic method to enable adequate treatment and prevent further spread. Enrichment of the bacteria is often used as a first step in diagnostics to increase the bacterial number above the detection limit of the real-time PCR. The enrichment of Brucella spp. takes at least 3 days, which might be avoidable if sensitive PCR methods can be used. Since many matrices contain PCR inhibitors, the limit of detection (LOD) must be determined for each separate matrix. Another aim of this study was the determination of survival of Brucella abortus in the analyzed matrices. METHODS: The LOD for the detection of B. abortus in 14 matrices, relevant for human medicine, veterinary medicine and food and feed safety, was determined to evaluate the need of a pre-enrichment step prior to real-time PCR. The survival of B. abortus in the spiked matrices was tested by plate count in a 7-day interval for 132 days. RESULTS: The limit of detection for B. abortus in most matrices was in the range of 10(3)-10(4) CFU/g for cultivation and 10(4)-10(5) CFU/g for direct real-time PCR. The survival time of B. abortus was less than 21 days in apple puree and stomach content and 28 days in water while B. abortus remained viable at day 132 in milk, blood, spinach and minced meat. CONCLUSIONS: A direct PCR analysis without enrichment of bacteria saves at least 3 days. However, the limit of detection between direct PCR and plate count differs in a 10 fold range. We conclude that this lower sensitivity is acceptable in most cases especially if quick analysis are required.

  • Slazak, Blazej
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi. Polish Acad Sci, W Szafer Inst Bot, Krakow, Poland.
    Kapusta, Malgorzata
    Univ Gdansk, Fac Biol, Dept Plant Cytol & Embryol, Gdansk, Poland.
    Strömstedt, Adam A.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Slomka, Aneta
    Jagiellonian Univ, Inst Bot, Dept Plant Cytol & Embryol, Gdansk, Poland.
    Krychowiak, Marta
    Univ Gdansk, Intercollegiate Fac Biotechnol, Lab Biol Act Cpds, Gdansk, Poland;Med Univ Gdansk, Gdansk, Poland.
    Shariatgorji, Mohammadreza
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Andrén, Per E.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Bohdanowicz, Jerzy
    Univ Gdansk, Fac Biol, Dept Plant Cytol & Embryol, Gdansk, Poland.
    Kuta, Elzbieta
    Jagiellonian Univ, Inst Bot, Dept Plant Cytol & Embryol, Gdansk, Poland.
    Göransson, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System2018Inngår i: Frontiers in Plant Science, ISSN 1664-462X, E-ISSN 1664-462X, Vol. 9, artikkel-id 1296Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Cyclotides are cyclic plant polypeptides of 27-37 amino acid residues. They have been extensively studied in bioengineering and drug development contexts. However, less is known about the relevance of cyclotides for the plants producing them. The anti-insect larvae effects of kB1 and antibacterial activity of cyO2 suggest that cyclotides are a part of plant host defense. The sweet violet (Viola odorata L.) produces a wide array of cyclotides, including kB1 (kalata B1) and cyO2 (cycloviolacin O2), with distinct presumed biological roles. Here, we evaluate V. odorata cyclotides' potency against plant pathogens and their mode of action using bioassays, liposome experiments and immunogold labeling for transmission electron microscopy (TEM). We explore the link between the biological activity and distribution in plant generative, vegetative tissues and seeds, depicted by immunohistochemistry and matrix assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI). Cyclotides cyO2, cyO3, cyO13, and cyO19 are shown to have potent activity against model fungal plant pathogens (Fusarium oxysporum, F. graminearum, F. culmorum, Mycosphaerella fragariae, Botrytis cinerea) and fungi isolated from violets (Colletotrichum utrechtense and Alternaria alternata), with minimal inhibitory concentrations (MICs) ranging from 0.8 to 25 mu M. Inhibition of phytopathogenic bacteria - Pseudomonas syringae pv. syringae, Dickeya dadantii and Pectobacterium atrosepticum - is also observed with MIC = 25-100 mu M. A membrane-disrupting antifungal mode of action is shown. Finding cyO2 inside the fungal spore cells in TEM images may indicate that other, intracellular targets may be involved in the mechanism of toxicity. Fungi can not break down cyclotides in the course of days. varv A (kalata S) and kB1 show little potency against pathogenic fungi when compared with the tested cycloviolacins. cyO2, cyO3, cyO19 and kB1 are differentially distributed and found in tissues vulnerable to pathogen (epidermis, rizodermis, vascular bundles, protodermis, procambium, ovary walls, outer integuments) and pest ( ground tissues of leaf and petiole) attacks, respectively, indicating a link between the cyclotides' sites of accumulation and biological role. Cyclotides emerge as a comprehensive defense system in V. odorata, in which different types of peptides have specific targets that determine their distribution in plant tissues.

  • Yngve, Agneta
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för kostvetenskap.
    Publiceringshandbok2018Rapport (Annet vitenskapelig)
  • Disputas: 2018-12-07 10:15 Rudbecksalen, C11, Uppsala
    Smith, Ross
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Vaskulärbiologi.
    Biological consequences of endothelial cell signaling2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Endothelial cells make up the inner lining of blood and lymphatic vessels, where they participate in functions vital to survival of the tissue; endothelial cells maintain vessel integrity, dynamically respond to the changing metabolic needs of tissues, and participate in many tissue-specific functions. Endothelial cells sense environmental cues which initiate signal transduction pathways that regulate behavior. Endothelial cell dysfunction is a feature of many diseases, such as cancer, atherosclerosis, and retinopathies and therefore knowledge of endothelial signal transduction pathways is important for designing therapies to treat these diseases.

    The receptor tyrosine kinase VEGFR2 is a master regulator of endothelial cell biology, regulating survival, growth, migration, angiogenesis and vessel permeability. VEGF stimulation of VEGFR2 results in phosphorylation of tyrosine residues in the receptor’s intracellular domain. The phosphorylation of Y949, Y1173, and Y1212 is known to initiate complex signaling pathways in endothelial cells, but it is still unclear how each individual phosphosite contributes to overall endothelial regulation.

     The scaffold protein palmdelphin has been found to be highly expressed in endothelial cells, though its role in endothelial biology is still unclear.

    In this thesis I present investigations of endothelial cell signaling pathways. In Paper I, we identify VEGFR2 pY1212 binding partners and use a mouse model to reveal the effect of abrogated Y1212 signaling in vivo. In Paper II, we investigate endothelial palmdelphin and establish that loss of palmdelphin in vitro and in vivo results in morphological changes for endothelial cells. Additionally, loss of palmdelphin leads to a misalignment of endothelial nuclei in response to flow, implicating palmdelpin in a mechanotransduction pathway. In Paper III, we use mouse models of proliferative retinopathy to demonstrate that loss of VEGFR2 Y949 signaling leads to a reduction or delay in neovascularization and a decrease in vessel leakage from pathological lesions.

    In summary, the investigation of endothelial cell signal transduction pathways can help us understand and unravel the complexities of vascular biology. Designing therapies which affect only a specific signaling axis has the potential to reduce side effects and optimize treatment.

  • Disputas: 2018-12-13 13:15 Ångström 2001, Uppsala
    Thomas, Simon
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Elektricitetslära.
    Control of Wave Energy Converters in arrays2018Licentiatavhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    One way to lower the levelized cost of energy for wave power plants and paving so the way for commercial success, is to increase the power absorption by use of advanced control algorithms. This thesis investigates the influence of the generator inertia, the generator damping and the layout on power absorption and presents a new model free strategy of controlling wave energy converters.

    The evaluation of all control strategies was done in a numerical simulation and in experimental 1:10 model scale wave tank tests conducted in the COAST laboratory at the University of Plymouth. The WECs used are inspired by the wave energy concept developed at Uppsala University.

    The influence of the generator inertia on the power absorption was tested with an uncontrolled WEC. Compared to a conventional WEC the power output could be significantly increased for small waves and high wave periods.   

    As a simple and easy to implement control strategy, a WEC with sea state optimized generator damping was used to create a power matrix. The optimal damping factor depends on both, wave period and wave height. The power absorption increases with the wave height and when the wave period converges towards the oscillation period of the WEC.

    A genetic algorithm was used to obtain the optimized layouts for wave energy farms, which suggest that the converter should be placed in rows parallel to the wave front, and the position in the array has nearly no influence on the optimal control parameter.

    Then a collaborative learning approach using machine learning is presented, with several identical wave energy converters in a row to parallelise the search of the optimal control parameter. It was implemented to control the generator damping factor and the latching time. With the latter the power could be increased significantly.

  • Kamwesiga, Julius T.
    et al.
    Uganda Allied Hlth Examinat Board, Kampala, Uganda;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat therapy, Stockholm, Sweden.
    Eriksson, Gunilla
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Rehabiliteringsmedicin. Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat therapy, Stockholm, Sweden.
    Tham, Kerstin
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat therapy, Stockholm, Sweden;Malmo Univ, Malmo, Sweden.
    Fors, Uno
    Stockholm Univ, Dept Comp & Syst Sci DSV, Stockholm, Sweden.
    Ndiwalana, Ali
    Knowledge Consulting Ltd, Kampala, Uganda.
    von Koch, Lena
    Karolinska Univ Hosp, Dept Neurol, Stockholm, Sweden;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat therapy, Stockholm, Sweden.
    Guidetti, Susanne
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Occupat therapy, Stockholm, Sweden.
    A feasibility study of a mobile phone supported family-centred ADL intervention, F@ce (TM), after stroke in Uganda2018Inngår i: Globalization and Health, ISSN 1744-8603, E-ISSN 1744-8603, Vol. 14, artikkel-id 82Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: There is a lack of evidence-based health services to reduce the impact of stroke in low-income countries at a personal, family or community level. The aim was to evaluate the feasibility of: i) a mobile phone supported family-centred intervention (F@ce (TM)), and ii) the study design for evaluating the effects of the intervention on the perceived impact of stroke; perceived participation in everyday life; and self-efficacy in everyday activities amongst persons with stroke and their families in Uganda. Methods: The study comprised a pre-post design with an intervention group (IG) receiving the F@ce (TM) and a control group (CG). The inclusion criteria's were: a) confirmed stroke diagnosis, b) access to and ability to use a mobile phone, c) ability to communicate in English and/or Luganda, d) > 18 years, e) residents in Kampala, and f) a Modified Rankin Scale level 2 to 4. The aimof the F@ce (TM) was to increase functioning in daily activities for persons living with the consequences of stroke, and participation in everyday life for persons with stroke and their families. The F@ce (TM) was an eight-week family-centred intervention, which entailed goal setting and problem-solving strategies, daily reminders and self-rated follow-ups of performance by short message service (SMS). Data were collected in the participants' home environment at baseline and after eight weeks. Data on acceptability of the F@ce (TM) and study procedures were collected by log-books and the responses of the SMS follow ups on the server. The primary outcomes were performance and satisfaction of valued daily activities in everyday life using the Canadian Occupational Performance Measure (COPM), self-efficacy in performance of activities in daily life. Results: The IG comprised n = 13 and the CG n = 15. There were differences between the IG and CG in changes between baseline and follow-up in the primary outcomes COPM (performance component) and self-efficacy in favour of F@ce (TM). Overall with minor modifications the intervention and the study design were feasible for all participants involved. Conclusion: The results support the need for further research to rigorously evaluate the effects of F@ceT (TM) since the intervention appears to be feasible for persons with stroke and their family members.

  • Guichard, Etienne
    et al.
    Univ Bologna, Dept Biol Geol & Environm Sci, I-40126 Bologna, Italy.
    Peona, Valentina
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Evolutionsbiologi. Univ Bologna, Dept Biol Geol & Environm Sci, I-40126 Bologna, Italy.
    Tagliazucchi, Guidantonio Malagoli
    Azienda Osped Univ Parma, Dept Res & Innovat, I-43126 Parma, Italy.
    Abitante, Lucia
    Univ Bologna, Dept Biol Geol & Environm Sci, I-40126 Bologna, Italy.
    Jagoda, Evelyn
    Harvard Univ, Human Evolutionary Biol, Cambridge, MA 02138 USA.
    Musella, Margherita
    Univ Bologna, Dept Biol Geol & Environm Sci, I-40126 Bologna, Italy.
    Ricci, Marco
    Univ Bologna, Dept Biol Geol & Environm Sci, I-40126 Bologna, Italy.
    Rubio-Roldan, Alejandro
    Univ Granada, Junta Andalucia Ctr Genom & Oncol Res, PTS Granada, GENYO,Pfizer, Granada 18007, Spain.
    Sarno, Stefania
    Univ Bologna, Dept Biol Geol & Environm Sci, I-40126 Bologna, Italy.
    Luiselli, Donata
    Univ Bologna, Dept Cultural Heritage, Ravenna Campus, I-48121 Ravenna, Italy.
    Pettener, Davide
    Univ Bologna, Dept Biol Geol & Environm Sci, I-40126 Bologna, Italy.
    Taccioli, Cristian
    Univ Padua, Dept Anim Med Prod & Hlth, I-35020 Legnaro, Pd, Italy.
    Pagani, Luca
    Univ Padua, Dept Biol, I-35131 Padua, Italy;Univ Tartu, Inst Genom, Estonian Bioctr, EE-51010 Tartu, Estonia.
    Luis Garcia-Perez, Jose
    Univ Granada, Junta Andalucia Ctr Genom & Oncol Res, PTS Granada, GENYO,Pfizer, Granada 18007, Spain;Univ Edinburgh, Western Gen Hosp, IGMM, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland.
    Boattini, Alessio
    Univ Bologna, Dept Biol Geol & Environm Sci, I-40126 Bologna, Italy.
    Impact of non-LTR retrotransposons in the differentiation and evolution of anatomically modern humans2018Inngår i: Mobile DNA, ISSN 1759-8753, E-ISSN 1759-8753, Vol. 9, artikkel-id 28Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Transposable elements are biologically important components of eukaryote genomes. In particular, non-LTR retrotransposons (N-LTRrs) played a key role in shaping the human genome throughout evolution. In this study, we compared retrotransposon insertions differentially present in the genomes of Anatomically Modern Humans, Neanderthals, Denisovans and Chimpanzees, in order to assess the possible impact of retrotransposition in the differentiation of the human lineage. Results: We first identified species-specific N-LTRrs and established their distribution in present day human populations. These analyses shortlisted a group of N-LTRr insertions that were found exclusively in Anatomically Modern Humans. These insertions are associated with an increase in the number of transcriptional/splicing variants of those genes they inserted in. The analysis of the functionality of genes containing human-specific N-LTRr insertions reflects changes that occurred during human evolution. In particular, the expression of genes containing the most recent N-LTRr insertions is enriched in the brain, especially in undifferentiated neurons, and these genes associate in networks related to neuron maturation and migration. Additionally, we identified candidate N-LTRr insertions that have likely produced new functional variants exclusive to modern humans, whose genomic loci show traces of positive selection. Conclusions: Our results strongly suggest that N-LTRr impacted our differentiation as a species, most likely inducing an increase in neural complexity, and have been a constant source of genomic variability all throughout the evolution of the human lineage.

  • Disputas: 2018-12-07 13:00 Lagerlöfsalen, 1A 305, Karlstad
    Ängeby, Karin
    Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), Institutionen för hälsovetenskaper (from 2013).
    Prolonged latent phase of labour: Prevalence, labour outcomes, quality of care, women’s experiences and preferences, and psychometric properties of a questionnaire2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The overall aim of this thesis was to investigate the prevalence and labour outcome of a prolonged latent phase of labour, quality of care, women’s experiences and preferences during labour, and to psychometrically test a questionnaire.

    Methods: Qualitative and quantitative methods. Sixteen primiparous women’s preferences for care during a prolonged latent phase of labour were studied with focus-group and individual interviews and analysed with content analysis (I). From a one-year cohort of 2660 women, 1554 women with a spontaneous onset of labour were invited to participate and 1389 women accepted invitation (II-IV). Data from 1343 women’s birth records were analysed with descriptive and analytic statistics (II). 758 women, (RR 64%), 343 primiparous and 415 multiparous, responded to the Intrapartal-specific Quality from Patients Perspective Questionnaire, QPP-I (III), the Early Labour Experience Questionnaire, ELEQ (IV) and additionally birth-related items. Data were analysed with descriptive, analytic, and psychometric statistics.

    Main findings: According to women’s self-reports, 23% of women with a spontaneous onset of labour had a prolonged latent phase (>18 hours), which was associated with more obstetrical interventions and instrumental births (II). These women preferred individualised care (I), rated the quality of their intrapartum care lower, were less content with the birth experience, and had more negative feelings during labour and birth than women with a shorter latent phase (III). The ELEQ was translated and adapted to Swedish and resulted in two questionnaires, one for primiparous women, SWE-ELEQ-PP, and one for multiparous women, SWE-ELEQ-MP. Both are valid and reliable and can be used to evaluate early labour care in Sweden (IV).

    Conclusions: A prolonged latent phase of labour can be regarded as a risk factor. It can result in more obstetrical interventions, more instrumental births, a lower perceived quality of care, and a more negative birth experience regardless of parity. Differences in parity must be considered when evaluating early labour care during the latent phase of labour, with special focus to primiparous women.

  • Malenova, Gabriela
    et al.
    KTH, Skolan för teknikvetenskap (SCI), Matematik (Inst.), Numerisk analys, NA. KTH, Centra, SeRC - Swedish e-Science Research Centre.
    Motamed, Mohammad
    KTH, Skolan för teknikvetenskap (SCI), Matematik (Inst.), Numerisk analys, NA. Department of Mathematics and Statistics, The University of New Mexico, Albuquerque, NM 87131, USA.
    Runborg, Olof
    KTH, Tidigare Institutioner (före 2005), Numerisk analys och datalogi, NADA. KTH, Skolan för teknikvetenskap (SCI), Matematik (Inst.), Numerisk analys, NA. KTH, Centra, SeRC - Swedish e-Science Research Centre.
    Regularity of stochastic observables in Gaussian beam superposition of high-frequency waves2017Inngår i: Research in mathematical sciences, ISSN 2197-9847Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    We consider high-frequency waves satisfying the scalar wave equation with highly oscillatory initial data. The wave speed, and the phase and amplitude of the initial data are assumed to be uncertain, described by a finite number of random variables with known probability distributions. We define quantities of interest (QoIs), or observables, as local averages of the squared modulus of the wave solution. We aim to quantify the regularity of these QoIs in terms of the input random parameters, and the wave length, i.e., to estimate the size of their derivatives. The regularity is important for uncertainty quantification methods based on interpolation in the stochastic space. In particular, the size of the derivatives should be bounded independently of the wave length. In this paper, we are able to show that when these QoIs are approximated by Gaussian beam superpositions, they indeed have this property, despite the highly oscillatory character of the waves.

  • Malenova, Gabriela
    et al.
    KTH, Skolan för teknikvetenskap (SCI), Matematik (Inst.), Numerisk analys, NA.
    Runborg, Olof
    KTH, Skolan för teknikvetenskap (SCI), Matematik (Inst.), Numerisk analys, NA. KTH, Centra, SeRC - Swedish e-Science Research Centre.
    Stochastic regularity of general quadratic observables of high frequency wavesManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    We consider solutions to the wave equation with uncertain initial data and medium, whose wavelength is short compared to thedistance traveled by the wave. We are interested in the statistics of the observables, i.e. functionals of the wave solution. Computation by direct methods gets very expensive or outright non-feasible as the wavelength decreases. To address the difficulties, we proposed a method consisting of the Gaussian beam method to treat the high frequencies and the sparse stochastic collocation method to remedy the curse of dimensionality in the stochastic space. For the latter method to converge, we need the observables to satisfy certain stochastic regularity conditions. The main contribution of this work is to show this regularity for a set of quadratic observables obtained by the Gaussian beam approximation of the wave solution.

  • Disputas: 2018-12-10 15:00 Lilla Jadwigasalen (12:108), Gävle
    Lim, Nancy Joy
    Högskolan i Gävle, Akademin för teknik och miljö, Avdelningen för Industriell utveckling, IT och Samhällsbyggnad, Samhällsbyggnad, GIS.
    Modelling, mapping and visualisation of flood inundation uncertainties2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Flood maps showing extents of predicted flooding for a given extreme event have wide usage in all types of spatial planning tasks, as well as serving as information material for the public. However, the production processes that these maps undergo (including the different data, methods, models and decisions from the persons generating them), which include both Geographic Information Systems (GIS) and hydraulic modelling, affect the map’s content, and will be reflected in the final map. A crisp flood boundary, which is a common way of representing the boundary in flood maps, may therefore not be the best representation to be used. They provide a false implication that these maps are correct and that the flood extents are absolute, despite the effects of the entire modelling in the prediction output. Hence, this research attempts to determine how flood prediction outputs can be affected by uncertainties in the modelling process. In addition, it tries to evaluate how users understand, utilise and perceive flood uncertainty information. 

    Three main methods were employed in the entire research: uncertainty modelling and analyses; map and geovisualisation development; and user assessment. The studies in this work showed that flood extents produced were influenced by the Digital Elevation Model (DEM) resolution and the Manning’s  used. This effect was further increased by the topographic characteristic of the floodplain. However, the performance measure used, which quantify how well a model produces result in relation to a reference floor boundary, had also biases in quantifying outputs. Determining the optimal model output, therefore, depended on outcomes of the goodness-of-fit measures used.

     In this research, several ways were suggested on how uncertainties can be visualised based on the data derived from the uncertainty assessment and by characterising the uncertainty information. These can be through: dual-ended maps; flood probability maps; sequential maps either highlighting the degrees of certainty (certainty map) or degrees of uncertainty (uncertainty map) in the data; binary maps; overlain flood boundaries from different calibration results; and performance bars. Different mapping techniques and visual variables were used for their representation. These mapping techniques employed, as well as the design of graphical representation, helped facilitate understanding the information by the users, especially when tested during the evaluations. Note though that there were visualisations, which the user found easier to comprehend depending on the task given. Each of these visualisations had also its advantages and disadvantages in communicating flood uncertainty information, as shown in the assessments conducted. Another important aspect that came out in the study was how the users’ background influence decision-making when using these maps. Users’ willingness to take risks depended not only on the map, but their perceptions on the risk itself. However, overall, users found the uncertainty maps to be useful to be incorporated in planning tasks.

  • Malenova, Gabriela
    et al.
    KTH, Skolan för teknikvetenskap (SCI), Matematik (Inst.), Numerisk analys, NA.
    Runborg, Olof
    KTH, Skolan för teknikvetenskap (SCI), Matematik (Inst.), Numerisk analys, NA.
    Fast evaluation of high frequency observables by by Gaussian beams and the numerical steepest descent methodManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    We consider observables (quantities of interest) of the wave equation where the initial data has a wavelength which is very small compared to the distance traveled by the wave. Computation by direct methods becomes expensive owing to the short wavelength. Therefore, two fast asymptotic methods are proposed to address the difficulties: the Gaussian beam method to approximate the wave solution, and the numerical steepest descent method to compute the quantity of interest. In this work, we demonstrate the use of the latter method and present the corresponding error estimates. We show that the latter method has a lower computational cost compared to the previously considered methods and present the corresponding error estimates.

  • Twizeyimana, Jean Damascene
    et al.
    Örebro universitet, Handelshögskolan vid Örebro Universitet. College of Science & Technology University of Rwanda, Kigali, Rwanda.
    Larsson, Hannu
    Örebro universitet, Handelshögskolan vid Örebro Universitet.
    Grönlund, Åke
    Örebro universitet, Handelshögskolan vid Örebro Universitet.
    E-government in Rwanda: Implementation, Challenges and Reflections2018Inngår i: Electronic Journal of e-Government, ISSN 1479-439X, E-ISSN 1479-439X, Vol. 16, nr 1, s. 19-31Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    E‑government is currently high on the agenda in many developing countries (DCs). While e‑government is well‑established in many developed countries it is new to least developed countries. Countries that start implementing e‑government today can benefit from easy import of modern technologies, but adaptation to local conditions and the organizational change that is required cannot be imported, but must be developed at home. By using examples of an ongoing initiative by the Government of Rwanda to digitalize all G2C and G2B into a single window platform, the current study investigated the important challenges in the implementation of e‑government in Rwanda. An interpretive case study was followed. Data was collected through interviews and participatory observations during August to December 2015. Data analysis was inductive, the analysis method was content analysis, and the coding followed open‑coding. NVivo software has been used to handle data and facilitate the analysis. The study found six overarching categories of aspects that challenge a successful implementation of e‑government in Rwanda. They include information infrastructure for e‑government, social inclusion, governance, management, trust in the new system, and languages. However, challenges to e‑government implementation should not be taken as of the same extent, neither their degree of mitigation. Rather, they influence and are influenced by various contextual factors which include political support, nature of the e‑government project, implementation strategies, human and socio‑economic development, existing information infrastructure, and operational capabilities. Having said this, we also argue that countries should learn from one another of their experiences, success stories, and mistakes. Despite a number of associated challenges, the adopted public‑private partnership (PPP) approach to e‑Government implementation in Rwanda might indeed seem as a suitable catalyst for e‑government success in the country.

    2.5.0.0

  • Anderson, Jennifer L
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Systematisk biologi. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Evolutionsbiologi.
    Nieuwenhuis, Bart P. S.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Evolutionsbiologi. Division of Evolutionary Biology, Faculty of Biology, Ludwig- Maximilians-Universität München.
    Johannesson, Hanna
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Evolutionsbiologi. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Systematisk biologi.
    Asexual reproduction and growth rate: independent and plastic lifehistory traits in Neurospora crassa2018Inngår i: The ISME Journal, ISSN 1751-7362, E-ISSN 1751-7370Artikkel i tidsskrift (Fagfellevurdert)
  • Disputas: 2018-12-07 10:15 Kollegiesalen, Stockholm
    Lim, Shyang Maw
    KTH, Skolan för teknikvetenskap (SCI), Mekanik, Strömningsfysik.
    Aerothermodynamics and exergy analysis in turbocharger radial turbine2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Coupling of turbomachine to reciprocating automotive engine in turbocharging leads to complex fluid flow and thermal characteristics in the turbine. Some undesirable characteristics include heat transfer, flow pulsation and secondary flow due to the complex geometry of the upstream exhaust manifold. The performed literature review exposed that there is a need for an enhanced understanding of the thermo-fluid physics of a turbocharger turbine operating under realistic on-engine conditions, and on quantifying the impact on the performance. Often, simplified set-ups and geometries are employed, neglecting the heat transfer.

    This dissertation aimed to improve the quality of heat transfer analysis in a turbocharger turbine, and to enhance the understanding of aerothermodynamic effects due to heat transfer on the performance under engine-like pulsatile flow scenarios. Firstly, a flow exergy based analysis was developed to be used with the input provided by three-dimensional flow field data predicted by Detached Eddy Simulation (DES). Its applicability to identify and to quantify the aerothermodynamic related losses due to heat transfer was thoroughly investigated with a set-up replicating a hot gas stand continuous flow scenario. Next, the developed methodology was applied to engine-like pulsatile flow scenarios, to investigate the effects of flow pulsation and the influences of upstream exhaust manifold on the heat transfer and turbine performance. For the investigated geometry and specified boundary conditions, this dissertation mainly concluded that 1) The most sensitive measures associated with heat loss are the flow exergy lost via heat transfer and the thermal irreversibilities. The influence of heat loss on turbine power reduction is small in a relative sense, and 2) Although the exhaust manifold characteristics govern the fundamental flow physics and heat transfer in the scroll, its impact on the turbine power seems to be small relatively. 

    The contributions with this dissertation were mainly twofold. Firstly, it contributes to a deeper understanding of the thermo-fluid physics of a turbocharger turbine operating under engine-like pulsating flow scenario. This knowledge might be useful for industrial product development in the future. Secondly, from academic perspective, the flow exergy budget analysis could potentially serve as a practical example to students in connecting the dots between classroom theory and real life engineering application.

  • Grönberg, Malin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Onkologisk endokrinologi.
    Nilsson, Cecilia
    Vastmanland Cty Hosp, Ctr Clin Res, Vasteras, Sweden.
    Markholm, Ida
    Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden;Lund Univ, CREATE Hlth Strateg Ctr Translat Canc Res, Lund, Sweden.
    Hedenfalk, Ingrid
    Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden;Lund Univ, CREATE Hlth Strateg Ctr Translat Canc Res, Lund, Sweden.
    Blomqvist, Carl
    Univ Helsinki, Dept Oncol, Helsinki, Finland;Orebro Univ Hosp, Dept Oncol, Orebro, Sweden.
    Holmberg, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Endokrinkirurgi. Kings Coll London, Fac Life Sci & Med, London, England.
    Tiensuu Janson, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Onkologisk endokrinologi.
    Fjällskog, Marie-Louise
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Onkologisk endokrinologi.
    Ghrelin expression is associated with a favorable outcome in male breast cancer2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 13586Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Ghrelin and obestatin are two gastrointestinal peptides, derived from a common precursor. Expression of both peptides have been found in breast cancer tissue and ghrelin has been associated with breast cancer development. Ghrelin expression is associated with longer survival in women diagnosed with invasive and node negative breast cancer. The clinical implications of the peptide expression in male breast cancer are unclear. The aim of this study was to investigate the role and potential clinical value of ghrelin and obestatin in male breast cancer. A tissue microarray of invasive male breast cancer specimens from 197 patients was immunostained with antibodies versus the two peptides. The expression of the peptides was correlated to previously known prognostic factors in breast cancer and to the outcome. No strong correlations were found between ghrelin or obestatin expression and other known prognostic factors. Only ghrelin expression was statistically significantly correlated to breast cancer-specific survival (HR 0.39, 95% CI 0.18-0.83) in univariate analyses and in multivariate models, adjusted for tumor size and node status (HR 0.38, 95% CI 0.17-0.87). HR for obestatin was 0.38 (95% CI 0.11-1.24). Ghrelin is a potential prognostic factor for breast cancer death in male breast cancer. Patients with tumors expressing ghrelin have a 2.5-fold lower risk for breast cancer death than those lacking ghrelin expression. Drugs targeting ghrelin are currently being investigated in clinical studies treating metabolic or nutritional disorders. Ghrelin should be further evaluated in forthcoming studies as a prognostic marker with the aim to be included in decision algorithms.

  • Janson, Christer
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
    Johansson, Gunnar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Ställberg, Björn
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Lisspers, Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Allmänmedicin och preventivmedicin.
    Olsson, Petter
    Novartis Sverige AB, Taby, Sweden.
    Keininger, Dorothy L.
    Novartis, Basel, Switzerland.
    Uhde, Milica
    IQVIA, Stockholm, Sweden.
    Gutzwiller, Florian S.
    Novartis, Basel, Switzerland.
    Jorgensen, Leif
    IQVIA, Copenhagen, Denmark.
    Larsson, Kjell
    Karolinska Inst, Solna, Sweden.
    Identifying the associated risks of pneumonia in COPD patients: ARCTIC an observational study2018Inngår i: Respiratory Research, ISSN 1465-9921, E-ISSN 1465-993X, Vol. 19, artikkel-id 172Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Inhaled corticosteroids (ICS) are associated with an increased risk of pneumonia in patients with chronic obstructive pulmonary disease (COPD). Other factors such as severity of airflow limitation and concurrent asthma may further raise the possibility of developing pneumonia. This study assessed the risk of pneumonia associated with ICS in patients with COPD.

    Methods: Electronic Medical Record data linked to National Health Registries were collected from COPD patients and matched reference controls in 52 Swedish primary care centers (2000-2014). Levels of ICS treatment (high, low, no ICS) and associated comorbidities were assessed. Patients were categorized by airflow limitation severity.

    Results: A total of 6623 patients with COPD and 48,566 controls were analyzed. Patients with COPD had a more than 4-fold increase in pneumonia versus reference controls (hazard ratio [HR] 4.76, 95% confidence interval [CI]: 4. 48-5.06). ICS use increased the risk of pneumonia by 20-30% in patients with COPD with forced expiratory volume in 1 s >= 50% versus patients not using ICS. Asthma was an independent risk factor for pneumonia in the COPD population. Multivariate analysis identified independent predictors of pneumonia in the overall population. The highest risk of pneumonia was associated with high dose ICS (HR 1.41, 95% CI: 1.23-1.62).

    Conclusions: Patients with COPD have a greater risk of pneumonia versus reference controls; ICS use and concurrent asthma increased the risk of pneumonia further.

  • Sukhin, V. S.
    et al.
    Danyliuk, S. V.
    Sukhina, O. N.
    Zadnepryanniy, A. V.
    Lindquist, David
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Hermelin, H.
    Tarján, M.
    The investigation of PD-L1 expression as a prognostic marker for uterine sarcoma2018Inngår i: Морфологія, ISSN 1997-9665, Vol. 12, nr 2, s. 62-71Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The uterine sarcoma is a rare tumor with the unpredictable, aggressive clinical behavior. Medical science relies on the development of reliable tumor markers, on the basis of which the optimal treatment program can be chosen, and will be also possible to make a prognosis. The hyperexpression of PD-L1 in many cases correlates with unfavorable prognosis of the disease and is an important prognostic biomarker for some types of tumors: melanoma, kidney cancer, non-small cell lung cancer. The role of PD-L1 expression, as a tumor marker in sarcoma, remains unclear. Objective. The investigation of PD-L1 expression as a prognostic tumor marker for uterine sarcoma.

    Methods: There have been selected 30 uterine sarcoma patients stage I-II (T1-2NxM0), for immunohistochemistry analyze of PD-L1 expression. Depending on the morphological tumor types all the patients were distributed: leiomyosarcoma (LMS) - 20.0%, endometrial stromal sarcoma (ESS) - 46.7%, undifferentiated sarcoma (HC) - 33.3%.

    Results: Our results showed that 73.3 % of patients with uterine sarcoma exhibited low expression level of PD-L1. The moderate level and overexpression of PD-L1 were observed in undifferentiated and endometrial stromal sarcoma - 13.3 and 6.7 %, respectively. At further follow-up of patients with PD-L1 expression, the relapse of the disease was detected in 50.0 % of cases.

    Conclusion: The PD-L1 expression in tumor tissue, regardless of its level, is considered to be an unfavorable prognostic factor for uterine sarcoma patients. In case of moderate expression level of PD-L1, so as at its overexpression, the tumor progression was detected in 83.3% of uterine sarcoma patients.

  • Napoli, Nicola
    et al.
    Univ Campus Biomed, Div Endocrinol & Diabet, Alvaro del Portillo 21, I-00128 Rome, Italy.
    Langdahl, Bente. L.
    Aarhus Univ Hosp, Aarhus, Denmark.
    Ljunggren, Östen
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Endokrinologi och mineralmetabolism.
    Lespessailles, Eric
    Univ Orleans, Orleans, France;Reg Hosp Orleans, Orleans, France.
    Kapetanos, George
    Papageorgiou Gen Hosp, Thessaloniki, Greece.
    Kocjan, Tomaz
    Univ Med Ctr, Ljubljana, Slovenia.
    Nikolic, Tatjana
    Univ Hosp, Zagreb, Croatia.
    Eiken, Pia
    Hillerod Hosp, Dept Cardiol Nephrol & Endocrinol, Hillerod, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
    Petto, Helmut
    Eli Lilly & Co, Windlesham, Surrey, England.
    Moll, Thomas
    Eli Lilly & Co, Windlesham, Surrey, England.
    Lindh, Erik
    Eli Lilly & Co, Windlesham, Surrey, England.
    Marin, Fernando
    Eli Lilly & Co, Windlesham, Surrey, England.
    Effects of Teriparatide in Patients with Osteoporosis in Clinical Practice: 42-Month Results During and After Discontinuation of Treatment from the European Extended Forsteo (R) Observational Study (ExFOS)2018Inngår i: Calcified Tissue International, ISSN 0171-967X, E-ISSN 1432-0827, Vol. 103, nr 4, s. 359-371Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This study aimed to describe clinical outcomes in patients prescribed teriparatide and followed up for 18months after stopping the drug in real-life conditions. The Extended Forsteo (R) Observational Study analysed incident clinical fractures in 6-month intervals using logistic regression with repeated measures. Changes in back pain (visual analogue scale) and health-related quality of life (HRQoL; EQ-5D questionnaire) were analysed using mixed models for repeated measures. Patients were analysed if they had a post-baseline visit, regardless of whether and for how long they took teriparatide. Of 1531 patients analysed (90.7% female, mean age: 70.3years), 76 (5.0%) never took teriparatide. Median treatment duration was 23.6months. The adjusted odds of clinical fracture decreased by 47% in the >12- to 18-month treatment period (p=0.013) compared with the first 6-month period, with no statistically significant reduction in the >18- to 24-month interval. The clinical fracture rate remained stable during the 18 months' post-teriparatide, when approximately 98% of patients took osteoporosis medication (51% bisphosphonates). Clinical vertebral fractures were reduced at every time period compared with the first 6months. Adjusted mean back pain scores decreased and EQ-5D scores increased significantly at each post-baseline observation. In a real-life clinical setting, the risk of clinical fractures declined during 24months of teriparatide treatment. This reduction was maintained 18months after stopping teriparatide. In parallel, patients reported significant improvements in back pain and HRQoL. The results should be interpreted in the context of the non-controlled design of this observational study.

  • Sukhin, V. S.
    et al.
    Danyliuk, S. V.
    Sukhina, O. M.
    Sadniprjaniy, O. V.
    Lindquist, David
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.
    Hermelin, H.
    Tarján, M.
    Expression of mmp-9 as a prognostic factor of uterine sarcoma2018Inngår i: Reports of morphology, ISSN 1818-1295, Vol. 24, nr 1, s. 21-27Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Uterine sarcoma is a highly aggressive mesenchymal neoplasm with an extremely unfavorable prognosis. Up today there are still relevant issues concerning search for clinical-morphological and biomolecular criteria for prognosis relapse-free survival of uterine sarcoma patients. It is well-known, the increase of the expression level of MMP-9 in primary tumor or metastatic foci correlates with a low differentiation of tumor cells, high ability for invasiveness, high metastatic activity, and shortened life expectancy. It’s still unknown, whether it is possible to consider the expression of MMP-9 in uterine sarcoma cells as a convincing prognostic factor. For many types of epithelial malignant neoplasms, high metastatic rate is associated with an increase level of MMP-9 both in plasma and in tumor tissue. The purpose of this study is to investigate the features of MMP-9 expression in uterine sarcoma cells for development of the model for individual prediction of the disease course. The study of the surgical material of selected 54 cases of uterine sarcoma of stage I-II (according to FIGO criteria) with a known prognosis of the disease, which were distributed depending on the morphological type done: leiomyosarcoma (LMS) – 18 cases, endometrial stromal sarcoma (ESS) - 22 cases, undifferentiated sarcoma (US) – 14 (according to the classification of tumors of the uterus of the WHO). For histological examination, pieces of tissue were cut from different parts of the tumor nodes – central, peripheral, parts of the adjacent intact tissue of myometrium (total of 6-8 bits). The tumor cell phenotype was determined using low molecular weight cytokeratins (Cytokeratin PAN, AE1 / AE3), smooth muscle actin (Smooth Muscle Actin, 1A4), myogenin (Myogenin (F5D)), CD 10 and vimentin (Vimentin, V9). The histochemical label was evaluated in two parameters: the degree of prevalence and intensity of coloration. To assess the color intensity, a qualitative scale was used: 0 – no reaction, 1+ – weak cytoplasmic coloration to 30.0% of tumor cells, 2+ – moderate reaction, 30.0 to 60.0% of stained cells, 3+ – pronounced cytoplasmic reaction in 60,0-100,0% of tumor cells. Statistical processing of the data was performed using the “STATISTICA 10.0” program package. The conducted study has showed, the negative (0) and weak (1+) expression of matrix metalloproteinase-9 were observed in the most part of ESS and only partially in US. Despite the stage of the disease, with such a status of MMP-9, there was observed no signs of relapsed disease. The moderate (2+) and high (3+) expression of MMP-9 was detected in 44.5 % of uterine sarcoma, in the most part in LMS patients. However, if in LMS cases the progressive disease was observed only in one third of them (4 of 12 cases), in case of ESS and US, in all the patients with such tumors status there was observed relapsed disease. Such a reaction may be indicative for invasive and metastatic potential of ESS and US and cause of the hematogenous metastases.

  • Tammiste, Lauri
    et al.
    Poltimäe, Helen
    Kuldna, Piret
    Kallaste, Tiit
    Kirsimaa, Kerli
    Grünvald, Olavi
    Kuusk, Kalle
    Technical report: Nordic Green to Scale for countries: Unlocking the potential of climate solutions in the Baltics, Poland and Ukraine2018Bok (Annet vitenskapelig)
    Abstract [en]

    This technical analysis for the Nordic Green to Scale for countries report was commissioned to Stockholm Environment Institute (SEI) Tallinn Centre. The project zooms in on two regions: the Baltic States, Poland and Ukraine in Europe; and Kenya and Ethiopia in East Africa. This report presents the emission reduction potential of 10 selected solutions for the European target countries. The study highlights the costs, savings and co-benefits of implementing the solutions as well as makes policy recommendations for capturing the potential. The project was carried out by the Finnish Innovation Fund Sitra, together with its partners CICERO, CONCITO and Institute of Sustainability Studies at the University of Iceland. The technical analysis was produced by the Stockholm Environment Institute Tallinn Centre. The project is part of the Nordic Council of Ministers' Prime Ministers’ Initiative.

  • Disputas: 2018-12-07 09:00 Hambergsalen, Uppsala
    Mattsson, Tobias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Mineralogi, petrologi och tektonik. Uppsala University.
    The dynamic emplacement of felsic magma in the upper crust2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Felsic magma intrudes earth’s upper crust through a variety of mechanisms. Magma intrusion growth and shape have mainly been explained in terms of host rock properties and intrusion depth, while considering the magma as an overpressurised fluid. However, volcanologists view a magma as a rheologically evolving fluid, which affects the magma flow in volcanic conduits. This thesis seeks to explore intrusion dynamics during magma emplacement by taking both the magma and the host rock into account. The first part of the thesis investigates the emplacement of the Sandfell laccolith/cryptodome, the Cerro Bayo cryptodome and the Mourne granite pluton. Both cryptodomes grew initially by inflation, which resulted in contact-parallel magma flow. Later during the emplacement, the rim of the intrusions viscously stalled as indicated by brecciation and fracturing in the intrusion rims, which then forced them to grow vertically. Our observations suggest that rheological changes in the magma during intrusion growth may control the shape of the cryptodomes/laccoliths. Previously proposed emplacement mechanisms of the Mourne Mountains granite pluton were tested by investigating host-rock deformation and the surrounding contact-metamorphic aureole. The aureole displays contact-metamorphic segregations that were later deformed by brecciation and shearing. The consistent regional fracture patterns in the pluton roof indicate that it was not widely domed, while the north-eastern wall of the pluton was deflected parallel to the strike of the contact. These observations suggest that multiple mechanisms emplaced the pluton, involving both floor subsidence and deflection of the roof and wall.

    The last part of the thesis studies the magma plumbing system to the Holuhraun 2014-15 eruption with mineral and whole-rock geochemistry and thermobarometry. The Holuhraun eruption was accompanied by subsidence in the Bárðarbunga caldera but occurred in the Askja volcanic system. Our results show that the Holuhraun eruption was fed from a vertically extensive magma plumbing system in the Bárðarbunga volcanic system.

    The works of this thesis highlight that felsic magma emplacement in the upper crust involves multiple and dynamic mechanisms that control the growth and shape of the intrusion and that the interplay between magma and host-rock properties needs to be considered.

  • Caiman, Cecilia
    et al.
    Stockholms universitet, Stockholm, Sweden.
    Hasslöf, Helen
    Malmö universitet, Malmö, Sweden.
    Lundegård, Iann
    Stockholms universitet, Stockholm, Sweden.
    Malmberg, Claes
    Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, Centrum för lärande, kultur och samhälle (CLKS), Lärande, Profession och Samhällsutveckling.
    Urbas, Anders
    Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, Centrum för lärande, kultur och samhälle (CLKS).
    Hela skolan för hållbar utveckling2018Inngår i: Lärportalen: Hållbar utveckling / [ed] Claes Malmberg, Stockholm: Skolverket , 2018, s. 1-13Kapittel i bok, del av antologi (Annet (populærvitenskap, debatt, mm))
    Abstract [sv]

    Den här delen avslutar modulen samtidigt som den blickar framåt mot arbetslagets och skolans utveckling. Syftet med delen är att bidra till hur skolans personal kan arbeta med att utveckla en skola som har som mål att i verksamheten som helhet arbeta med hållbarhet.

    I delen presenteras en modell för hur en skola kan arbeta med skolutveckling som en demokratisk process. Delen diskuterar Framtidsverkstad, som är en metod för att starta en förändringsprocess. Den visar ett exempel från en skola och hur ett arbetslag genomför en framtidsverkstad. Ni får även möjlighet att pröva att genomföra en framtidsverkstad på den egna skolan. Delen tar också upp idéer om organisationsförändring.

  • Disputas: 2018-12-04 09:00 Betula, Byggnad 6M, Umeå
    Rawcliffe, Denise F. R.
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Medicinsk och klinisk genetik.
    The regulation of incorrect splicing of ISCU in hereditary myopathy with lactic acidosis2018Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Patients suffering from hereditary myopathy with lactic acidosis (HML) can be found in the northern Swedish counties of Ångermanland and Västerbotten. HML is a rare autosomal recessive disease where patients display a low tolerance to exercise at an early age. Exercise can trigger symptoms such as palpitations, tachycardia, muscle cramps and dyspnoea. Extensive exercise or strict diets can result in myoglobinuria and life-threatening levels of lactic acid. The disease is caused by a nonsense G > C mutation (c.418 + 328G < C) in the last intron of the iron-sulphur (FeS) cluster assembly gene (ISCU), resulting in nonsense-mediated decay (NMD) of the transcript due to incorrect splicing. The ISCU protein is involved in the assembly of FeS clusters, which are essential cofactors for a wide range of proteins. Patient muscles display decreased levels of several FeS cluster proteins: mitochondrial aconitase in the tricarboxylic acid (TCA) cycle and Complex I, II (succinate dehydrogenase [SDH]) and III in the electron transport chain (ETC). The incorrect splicing of ISCU occurs to the highest extent in HML patient skeletal muscle, restricting the loss of ISCU protein to muscles, thereby preventing a more severe phenotype.

    We found that the incorrect splicing occurs to the highest extent in slow-fibre muscle, which may be caused by the serine/arginine-rich splicing factor (SRSF3) as it is expressed at higher levels in slow-fibre muscle compared to other muscles, and since it is able to activate the incorrect splicing of ISCU. Following muscle, there is a gradual decrease of the incorrect splicing in heart, brain, liver and kidney, which is negatively correlated with the levels of the splicing inhibitor polypyrimidine-tract binding protein 1 (PTBP1). Overexpression of PTBP1 in HML patient myoblasts resulted in a drastic decrease in the incorrect splicing, while a PTBP1 knockdown had the opposite effect. Our results suggest that PTBP1 acts as a dominant inhibitor of the incorrect splicing and is likely the main cause for the tissue-specific splicing of ISCU in HML. We also identified RBM39 and MBNL1 as activators of the incorrect splicing of ISCU, which, together with the low levels of PTBP1, could explain the high levels of incorrect splicing in muscle.

    Since almost 95% of all human gene transcripts are alternatively spliced, it is not surprising that a wide range of diseases are caused by mutations that affect splicing. Further knowledge of the function of splicing, such as tissue-specific splicing, can provide vital information for the development of therapies for diseases caused by splicing.

  • Engwall, Lars
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Företagsekonomiska institutionen.
    Structural Conditions for Interdisciplinarity2018Inngår i: European Review, Vol. 26, nr S2, s. S30-S40Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Analysing structural conditions for interdisciplinarity, this paper focuses on the characteristics of four factors in the organization of the sciences: disciplines, institutions, rewards and funding. It is argued that interdisciplinarity is less likely to involve disciplines that are strongly integrated, i.e. where task uncertainty is low and the dependence among researchers is high. Likewise, it is claimed that interdisciplinarity is likely to be hampered by strong departmental organization structures. Interdisciplinarity is also considered to become ess likely as quality control is specifically discipline oriented and also when funding is concentrated and in the hands of scientific elites. In contrast, interdisciplinary researchmay be found in research environments with weakly integrated disciplines in institutions with weak or no departmental structures, and where disciplinary reward systems are weak in systems with a variety of funding.

  • Hultman, Kristin
    et al.
    Department of Physiotherapy, Ryhov County Hospital, Jönköping, Sweden.
    Fältström, Anne
    Department of Physiotherapy, Ryhov County Hospital, Jönköping, Sweden.
    Öberg, Ulrika
    Futurum – The Academy of Healthcare, County Council Jönköping, Sweden.
    The effect of early physiotherapy after an acute ankle sprain2010Inngår i: Advances in Physiotherapy, ISSN 1403-8196, E-ISSN 1651-1948, Vol. 12, nr 2, s. 65-73Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Ankle sprain is one of the most common injuries treated in emergency departments (ED). In clinical practice, these injuries are expected to heal by themselves, often without any treatment other than short information about the RICE regime (rest, ice, compression and elevation). Still, remaining symptoms are reported to occur in 30% of the cases. The aim of this study was to evaluate the effect of early physiotherapy intervention after an acute ankle sprain. Sixty-five patients were recruited from the ED at a general hospital in Sweden (mean age 35 years; 30 women), and allocated into an intervention group with early physiotherapy or a control group. Both groups were evaluated 6 weeks and 3 months after their injury. As primary outcome, the disease-specific Foot and Ankle Outcome Score (FAOS) was used. The patients also rated their physical activity ability and how satisfied they were with their ankle on a visual analogue scale (VAS). The intervention group made significant improvements compared with the control group at both evaluations measured with FAOS and the VAS questions. These findings indicate that early physiotherapy intervention has a positive effect on patient-focused foot and ankle function after an acute ankle sprain. © 2010 Informa UK Ltd.

  • Rydback, Michelle
    Högskolan i Gävle, Akademin för utbildning och ekonomi, Avdelningen för ekonomi, Företagsekonomi. Södertörns högskola.
    Medical Tourism Facilitator in an Emerging Market Context2018Inngår i: 11th Annual Conference of the EuroMed Academy of Business: Research Advancements in National and Global Business Theory and Practice / [ed] Vrontis, D., Weber, Y. & Tsoukatos, E., EuroMed Press , 2018, , s. 3s. 1706-1708Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Employing Lovelock (1995) supplementary service model, this paper aims to examine how MTFs operationalize in the MT industry in the context of an EM. Qualitative approached using case-study methodology is employed in this paper. Three local medical tourism facilitators were selected for investigation. Data analysis was done using within and cross pattern that facilitated by NVivo. Lovelocks supplementary service model is not fully validated in the study. Thus revise model is presented. Additional two supplementary services emerge from empirical findings: linking diverse stakeholders (i.e., catalyzing collaboration) and alleviating the unfavorable reputation of the country (i.e., promotion of quality, mitigating ambiguity in patients’ experience).

  • Ren, Zhengyong
    et al.
    Cent S Univ, Minist Educ, Key Lab Metallogen Predict Nonferrous Met & Geol, Changsha 410083, Hunan, Peoples R China;Cent S Univ, Sch Geosci & Infophys, Changsha 410083, Hunan, Peoples R China.
    Zhong, Yiyuan
    Cent S Univ, Sch Geosci & Infophys, Changsha 410083, Hunan, Peoples R China.
    Chen, Chaojian
    Cent S Univ, Sch Geosci & Infophys, Changsha 410083, Hunan, Peoples R China.
    Tang, Jingtian
    Cent S Univ, Minist Educ, Key Lab Metallogen Predict Nonferrous Met & Geol, Changsha 410083, Hunan, Peoples R China;Cent S Univ, Sch Geosci & Infophys, Changsha 410083, Hunan, Peoples R China.
    Kalscheuer, Thomas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Geofysik.
    Maurer, Hansruedi
    Swiss Fed Inst Technol, Inst Geophys, Dept Earth Sci, CH-8092 Zurich, Switzerland.
    Li, Yang
    Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Beijing 100029, Peoples R China.
    Gravity Gradient Tensor of Arbitrary 3D Polyhedral Bodies with up to Third-Order Polynomial Horizontal and Vertical Mass Contrasts2018Inngår i: Surveys in geophysics, ISSN 0169-3298, E-ISSN 1573-0956, Vol. 39, nr 5, s. 901-935Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    During the last 20 years, geophysicists have developed great interest in using gravity gradient tensor signals to study bodies of anomalous density in the Earth. Deriving exact solutions of the gravity gradient tensor signals has become a dominating task in exploration geophysics or geodetic fields. In this study, we developed a compact and simple framework to derive exact solutions of gravity gradient tensor measurements for polyhedral bodies, in which the density contrast is represented by a general polynomial function. The polynomial mass contrast can continuously vary in both horizontal and vertical directions. In our framework, the original three-dimensional volume integral of gravity gradient tensor signals is transformed into a set of one-dimensional line integrals along edges of the polyhedral body by sequentially invoking the volume and surface gradient (divergence) theorems. In terms of an orthogonal local coordinate system defined on these edges, exact solutions are derived for these line integrals. We successfully derived a set of unified exact solutions of gravity gradient tensors for constant, linear, quadratic and cubic polynomial orders. The exact solutions for constant and linear cases cover all previously published vertex-type exact solutions of the gravity gradient tensor for a polygonal body, though the associated algorithms may differ in numerical stability. In addition, to our best knowledge, it is the first time that exact solutions of gravity gradient tensor signals are derived for a polyhedral body with a polynomial mass contrast of order higher than one (that is quadratic and cubic orders). Three synthetic models (a prismatic body with depth-dependent density contrasts, an irregular polyhedron with linear density contrast and a tetrahedral body with horizontally and vertically varying density contrasts) are used to verify the correctness and the efficiency of our newly developed closed-form solutions. Excellent agreements are obtained between our solutions and other published exact solutions. In addition, stability tests are performed to demonstrate that our exact solutions can safely be used to detect shallow subsurface targets.

  • Eriksson, Per
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Lindskog, Cecilia
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Engholm, Ebbe
    Univ Copenhagen, Chem Biol, Dept Chem, DK-1871 Frederiksberg C, Denmark.
    Blixt, Ola
    Univ Copenhagen, Chem Biol, Dept Chem, DK-1871 Frederiksberg C, Denmark.
    Waldenstrom, Jonas
    Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, SE-39231 Kalmar, Sweden.
    Munster, Vincent
    NIAID, Lab Virol, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA.
    Lundkvist, Åke
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Olsen, Bjorn
    Uppsala Univ, Zoonosis Sci Ctr, Dept Med Sci, SE-75123 Uppsala, Sweden.
    Jourdain, Elsa
    INRA, EPIA, VetAgro Sup, UMR0346, FR-63122 St Genes Champanelle, France.
    Ellstrom, Patrik
    Uppsala Univ, Zoonosis Sci Ctr, Dept Med Sci, SE-75123 Uppsala, Sweden.
    Characterization of avian influenza virus attachment patterns to human and pig tissues2018Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, artikkel-id 12215Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Wild birds of Anseriformes and Charadriiformes are natural reservoirs of influenza A viruses (IAVs). Occasionally, IAVs transmit and adapt to mammalian hosts, and are maintained as epidemic strains in their new hosts. Viral adaptions to mammalian hosts include altered receptor preference of host epithelial sialylated oligosaccharides from terminal alpha 2,3-linked sialic acid (SA) towards alpha 2,6-linked SA. However, alpha 2,3-linked SA has been found in human respiratory tract epithelium, and human infections by avian IAVs (AIVs) have been reported. To further explore the attachment properties of AIVs, four AIVs of different subtypes were investigated on human and pig tissues using virus histochemistry. Additionally, glycan array analysis was performed for further characterization of IAVs' receptor structure tropism. Generally, AIV attachment was more abundant to human tissues than to pig tissues. The attachment pattern was very strong to human conjunctiva and upper respiratory tract, but variable to the lower respiratory tract. AIVs mainly attached to alpha 2,3-linked SA, but also to combinations of alpha 2,3-and alpha 2,6-linked SA. The low attachment of these AIV isolates to pig tissues, but high attachment to human tissues, addresses the question whether AIVs in general require passage through pigs to obtain adaptions towards mammalian receptor structures.

  • Nordlund, Jessica
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Syvänen, Ann-Christine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Epigenetics in pediatric acute lymphoblastic leukemia2018Inngår i: Seminars in Cancer Biology, ISSN 1044-579X, E-ISSN 1096-3650, Vol. 51, s. 129-138Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. ALL arises from the malignant transformation of progenitor B- and T-cells in the bone marrow into leukemic cells, but the mechanisms underlying this transformation are not well understood. Recent technical advances and decreasing costs of methods for high-throughput DNA sequencing and SNP genotyping have stimulated systematic studies of the epigenetic changes in leukemic cells from pediatric ALL patients. The results emerging from these studies are increasing our understanding of the epigenetic component of leukemogenesis and have demonstrated the potential of DNA methylation as a biomarker for lineage and subtype classification, prognostication, and disease progression in ALL. In this review, we provide a concise examination of the epigenetic studies in ALL, with a focus on DNA methylation and mutations perturbing genes involved in chromatin modification, and discuss the future role of epigenetic analyses in research and clinical management of ALL.

  • Carlsund, Åsa
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad. Swedish Family Care Competence Centre, Kalmar, Sweden.
    Johansson, Pauline
    Swedish Family Care Competence Centre, Kalmar, Sweden; Linneus University Kalmar, Sweden.
    Hammare, Ulf
    Swedish Family Care Competence Centre, Kalmar, Sweden; Ersta Sköndal University College Stockholm, Sweden.
    Hanson, Elizabeth
    Swedish Family Care Competence Centre, Kalmar, Sweden; Linneus University Kalmar, Sweden.
    Support for Children as Next of Kin and Systematic Follow up -Group Leaders’ and Managers’ Perspectives Within Non-profit Organizations in Sweden2017Inngår i: Open Family Studies Journal, ISSN 1874-9224, Vol. 9, s. 49-59Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Abstract:Method:The aim of this study was to explore the systematic follow up of supportive activities in non-profit organizations targeted at childrenas next of kin. Managers and group leaders were interviewed, and findings were content analysed.Result:The findings indicated that a child focus, education, safety and trust were important. These factors were observed as the primarytasks and the key reason for being involved in supportive activities. Managers expressed concern about not retaining funding, if theorganization was unable to demonstrate the effects of their activities. Namely, to enhance the health and wellbeing of children. Inorder to continuously develop their work most organisations explained that they used some form of system for follow up. However,there was a wide variation in how non-profit organizations worked with follow ups.Conclusion:Overall, it was evident that there was a major need for education and support in this area.