1234567 1 - 50 of 1275
rss atomLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
  • Public defence: 2018-03-12 09:00 B/A1:111a, Uppsala
    van der Schot, Gijs
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular biophysics.
    Imaging Living Cells with an X-ray Laser2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Imaging living cells at a resolution higher than the resolution of optical microscopy is a significant challenge. Fluorescence microscopy can achieve a degree of super-resolution via labeling cellular components with a fluorescent dye. Reaching nanometer or sub-nanometer resolution requires high-energy radiation with significantly shorter wavelength than that of optical light. X-rays and electrons have the requisite wavelengths and could be suitable for such studies; however, these probes also cause significant radiation damage. A dose in excess of 100,000,000 Gray (Gy, J/kg) would be required to reach nanometer resolution on a cell, and no cell can survive this amount of radiation. As a consequence, much of what we know about cells at high resolution today comes from dead material.

    Theory predicts that an ultra-short and extremely bright coherent X-ray pulse from an X-ray free-electron laser can outrun key damage processes to deliver a molecular-level snapshot of a cell that is alive at the time of image formation. The principle of ‘diffraction before destruction’ exploits the difference between the speed of light (the X-ray pulse) and the much slower speed of damage formation. The femtosecond pulse ‘freezes’ motion in the cell at physiological temperatures on the time scale of atomic vibrations, offering unprecedented time resolution and a plethora of new experimental possibilities.

    This thesis describes the first test experiments on imaging living cells with an X-ray laser. I present results in three essential areas of live cell imaging. (i) We have used an aerosol injector to introduce live cyanobacteria into the X-ray focus, and recorded diffraction patterns with extremely low background at very high hit rates. (ii) We demonstrated scattered signal beyond 4 nm resolution in some of these experiments. (iii) The thesis also describes image reconstruction, using a new fully automated pipeline that I developed during my studies. The reconstruction of diffraction patterns was successful for all patterns that did not have saturated pixels. The new software suite, called RedFlamingo, selects exposures with desired properties, can sort them according to sample size, shape, orientation, exposure, the number and type of objects in the beam during the exposure, their distance from each other, and so forth. The software includes validation tools to assess the quality of the reconstructions.

  • Aaboud, M.
    et al.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    De Bruin, Pedro Sales
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Femtoscopy with identified charged pions in proton-lead collisions at root s(NN)=5.02 TeV with ATLAS2017In: Physical Review C: Covering Nuclear Physics, ISSN 2469-9985, E-ISSN 2469-9993, Vol. 96, no 6, article id 064908Article in journal (Refereed)
    Abstract [en]

    Bose-Einstein correlations between identified charged pions are measured for p+Pb collisions at root s(NN) = 5.02 TeV using data recorded by the ATLAS detector at the CERN Large Hadron Collider corresponding to a total integrated luminosity of 28 nb(-1). Pions are identified using ionization energy loss measured in the pixel detector. Two-particle correlation functions and the extracted source radii are presented as a function of collision centrality as well as the average transverse momentum (k(T)) and rapidity (y*(pi pi)) of the pair. Pairs are selected with a rapidity -2 < y*(pi pi) < 1 and with an average transverse momentum 0.1 < k(T) < 0.8 GeV. The effect of jet fragmentation on the two-particle correlation function is studied, and a method using opposite-charge pair data to constrain its contributions to the measured correlations is described. The measured source sizes are substantially larger in more central collisions and are observed to decrease with increasing pair k(T). A correlation of the radii with the local charged-particle density is demonstrated. The scaling of the extracted radii with the mean number of participating nucleons is also used to compare a selection of initial-geometry models. The cross term R-ol is measured as a function of rapidity, and a nonzero value is observed with 5.1 sigma combined significance for -1 < y*pi pi < 1 in the most central events.

  • Edueng, Khadijah
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy. Kulliyyah of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, Malaysia.
    Mahlin, Denny
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    Bergström, Christel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
    The Need for Restructuring the Disordered Science of Amorphous Drug Formulations2017In: Pharmaceutical Research, ISSN 0724-8741, Vol. 34, no 9, p. 1754-1772Article, review/survey (Refereed)
    Abstract [en]

    The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of the attractive approaches to enhance solubility is via amorphization despite the stability issue associated with it. Although the number of amorphous-based research reports has increased tremendously after year 2000, little is known on the current research practice in designing amorphous formulation and how it has changed after the concept of solid dispersion was first introduced decades ago. In this review we try to answer the following questions: What model compounds and excipients have been used in amorphous-based research? How were these two components selected and prepared? What methods have been used to assess the performance of amorphous formulation? What methodology have evolved and/or been standardized since amorphous-based formulation was first introduced and to what extent have we embraced on new methods? Is the extent of research mirrored in the number of marketed amorphous drug products? We have summarized the history and evolution of amorphous formulation and discuss the current status of amorphous formulation-related research practice. We also explore the potential uses of old experimental methods and how they can be used in tandem with computational tools in designing amorphous formulation more efficiently than the traditional trial-and-error approach.

  • Mietala, Johanna
    SCB.
    Data om svenska fiskodlingar: Utveckling av metodik inför rapportering till HELCOM2012Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    Utgångspunkten för denna rapport är att undersöka huruvida data om svenska fisk-odlingar från den nuvarande populationen i SMP produktionsmässigt täcker den population som studeras i SCBs årliga Vattenbruksrapport. En andra frågeställning är hur väl de emissionsfaktorer som användes vid den förra rapporteringen av PLC Annual 2005 stämmer med data från miljörapporterna.

    Totala kväve- och fosforutsläpp samt produktionsdata jämförs mellan de två data-materialen i denna studie. Resultaten visar att 1) fosforutsläppen kommer att to-talskattas 10 % lägre och kväveutsläppen 29 % högre med produktionsdata från Vattenbruksrapporten och emissionsfaktorer jämfört med inrapporterade värden från SMP som enda datakälla 2) användning av emissionsfaktorer och produkt-ionsuppgifter från undersökningen Vattenbruk 2010 medför en underskattning på totalt fosforutsläpp om 11 % och en överskattning av kväveutsläppet med 36 % för de 31 anläggningar i SMP populationen där jämförelse varit möjlig på enskild fis-keodlingsnivå 3) jämförelser mellan produktionsdata angivet i miljörapporternas textdelar och produktionsdata för Vattenbruk 2010 är osäkra på grund av otillräck-lig information i textdelarna.

    Att kombinera uppgifter från de båda undersökningarna är såsom uppgifter om fiskodlingarna samlas in idag att rekommendera men kan uppskattas som mer tidskrävande än att endast använda sig av en av dessa uppgiftskällor. Detta ef-tersom datamaterialet behöver matchas på anläggningsnivå för att säkerställa emissionsfaktorernas relevans vid varje rapporteringstillfälle. Emellertid är detta även en tillgång eftersom statistiken blir mer finfördelad.

  • Aaboud, M.
    et al.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    De Bruin, Pedro Sales
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Search for direct top squark pair production in final states with two leptons in root s=13 TeV pp collisions with the ATLAS detector2017In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 77, no 12, article id 898Article in journal (Refereed)
    Abstract [en]

    The results of a search for direct pair production of top squarks in events with two opposite-charge leptons (electrons or muons) are reported, using 36.1 fb(-1) of integrated luminosity from proton-proton collisions at root s = 13 TeV collected by the ATLAS detector at the Large Hadron Collider. To cover a range of mass differences between the top squark (t) over tilde and lighter supersymmetric particles, four possible decay modes of the top squark are targeted with dedicated selections: the decay (t) over tilde -> b (chi) over tilde (+/-)(1) into a b-quark and the lightest chargino with (chi) over tilde (+/-)(1) W (chi) over tilde (0)(1),the decay (t) over tilde -> t (chi) over tilde (0)(1) into an on-shell top quark and the lightest neutralino, the three-body decay (t) over tilde -> bW (chi) over tilde (0)(1) and the four-body decay (t) over tilde -> bl nu(chi) over tilde (0)(1). No significant excess of events is observed above the Standard Model background for any selection, and limits on top squarks are set as a function of the (t) over tilde and (chi) over tilde (0)(1) masses. The results exclude at 95% confidence level (t) over tilde masses up to about 720 GeV, extending the exclusion region of supersymmetric parameter space covered by previous searches.

  • Nordström, Jan
    et al.
    Linköping University, Department of Mathematics, Computational Mathematics. Linköping University, Faculty of Science & Engineering.
    Frenander, Hannes
    Linköping University, Department of Mathematics, Computational Mathematics. Linköping University, Faculty of Science & Engineering.
    On Long Time Error Bounds for the Wave Equation on Second Order Form2018In: Journal of Scientific Computing, ISSN 0885-7474, E-ISSN 1573-7691Article in journal (Refereed)
    Abstract [en]

    Temporal error bounds for the wave equation expressed on second order form are investigated. We show that, with appropriate choices of boundary conditions, the time and space derivatives of the error are bounded even for long times. No long time bound on the error itself is obtained, although numerical experiments indicate that a bound exists.

  • Aaboud, M.
    et al.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    De Bruin, Pedro Sales
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Determination of the strong coupling constant alpha(s) from transverse energy-energy correlations in multijet events at root s=8 TeV using the ATLAS detector2017In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 77, no 12, article id 872Article in journal (Refereed)
    Abstract [en]

    Measurements of transverse energy-energy correlations and their associated asymmetries in multi-jet events using the ATLAS detector at the LHC are presented. The data used correspond to vs = 8 TeV proton-proton collisions with an integrated luminosity of 20.2 fb(-1). The results are presented in bins of the scalar sum of the transverse momenta of the two leading jets, unfolded to the particle level and compared to the predictions from Monte Carlo simulations. A comparison with next-to-leading-order perturbative QCD is also performed, showing excellent agreement within the uncertainties. From this comparison, the value of the strong coupling constant is extracted for different energy regimes, thus testing the running of alpha(s)(mu) predicted in QCD up to scales over 1 TeV. A global fit to the transverse energy-energy correlation distributions yields alpha(s)(m(Z)) = 0.1162 +/- 0.0011 (exp.)(-0.0070)(+0.0084) (theo.), while a global fit to the asymmetry distributions yields a value of alpha(s)(m(Z)) = 0.1196 +/- 0.0013 (exp.)(-0.0045)(+0.0075) (theo.).

  • Public defence: 2018-03-16 10:00 Q2, Stockholm
    Verginis, Christos
    KTH, School of Electrical Engineering and Computer Science (EECS), Automatic Control.
    Planning and Control of Cooperative Multi-Agent Manipulator-Endowed Systems2018Licentiate thesis, monograph (Other academic)
    Abstract [en]

    Multi-agent planning and control is an active and increasingly studied topic of research, with many practical applications, such as rescue missions, security, surveillance, and transportation. More specifically, cases that involve complex manipulator-endowed systems  deserve extra attention due to potential complex cooperative manipulation tasks and their interaction with the environment. This thesis addresses the problem of cooperative motion- and task-planning of multi-agent and multi-agent-object systems under complex specifications expressed as temporal logic formulas. We consider manipulator-endowed robotic agents that can coordinate in order to perform, among other tasks, cooperative object manipulation/transportation. Our approach is based on the integration of tools from the following areas: multi-agent systems, cooperative object manipulation, discrete abstraction design of multi-agent-object systems, and formal verification. More specifically, we divide the main problem into three different parts.The first part is devoted to the control design for the formation control of a team of rigid-bodies, motivated by its application to cooperative manipulation schemes. We propose decentralized control protocols such that desired position and orientation-based formation between neighboring agents is achieved. Moreover, inter-agent collisions and connectivity breaks are guaranteed to be avoided. In the second part, we design continuous control laws explicitly for the cooperative manipulation/transportation of an object by a team of robotic agents. Firstly, we propose robust decentralized controllers for the trajectory tracking of the object's center of mass.  Secondly, we design model predictive control-based controllers for the transportation of the object with collision and singularity constraints. In the third part, we design discrete representations of multi-agent continuous systems and synthesize hybrid controllers for the satisfaction of complex tasks expressed as temporal logic formulas. We achieve this by combining the results of the previous parts and by proposing appropriate trajectory tracking- and potential field-based continuous control laws for the transitions of the agents among the discrete states. We consider teams of unmanned aerial vehicles and mobile manipulators as well as multi-agent-object systems where the specifications of the objects are also taken into account.Numerical simulations and experimental results verify the claimed results.

  • Ajeani, Judith
    et al.
    Ayiasi, Richard Mangwi
    Tetui, Moses
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. Makerere University School of Public Health (MakSPH), Makerere University College of Health Sciences, Kampala, Uganda.
    Ekirapa-Kiracho, Elizabeth
    Namazzi, Gertrude
    Kananura, Rornald Muhumuza
    Kiwanuka, Suzanne Namusoke
    Beyeza-Kashesya, Jolly
    A cascade model of mentorship for frontline health workers in rural health facilities in Eastern Uganda: processes, achievements and lessons2017In: Global Health Action, ISSN 1654-9716, E-ISSN 1654-9880, Vol. 10, article id 1345497Article in journal (Refereed)
    Abstract [en]

    Background: There is increasing demand for trainers to shift from traditional didactic training to innovative approaches that are more results-oriented. Mentorship is one such approach that could bridge the clinical knowledge gap among health workers.

    Objectives: This paper describes the experiences of an attempt to improve health-worker performance in maternal and newborn health in three rural districts through a mentoring process using the cascade model. The paper further highlights achievements and lessons learnt during implementation of the cascade model.

    Methods: The cascade model started with initial training of health workers from three districts of Pallisa, Kibuku and Kamuli from where potential local mentors were selected for further training and mentorship by central mentors. These local mentors then went on to conduct mentorship visits supported by the external mentors. The mentorship process concentrated on partograph use, newborn resuscitation, prevention and management of Post-Partum Haemorrhage (PPH), including active management of third stage of labour, preeclampsia management and management of the sick newborn. Data for this paper was obtained from key informant interviews with district-level managers and local mentors.

    Results: Mentorship improved several aspects of health-care delivery, ranging from improved competencies and responsiveness to emergencies and health-worker professionalism. In addition, due to better district leadership for Maternal and Newborn Health (MNH), there were improved supplies/medicine availability, team work and innovative local problem-solving approaches. Health workers were ultimately empowered to perform better.

    Conclusions: The study demonstrated that it is possible to improve the competencies of frontline health workers through performance enhancement for MNH services using locally built capacity in clinical mentorship for Emergency Obstetric and Newborn Care (EmONC). The cascade mentoring process needed strong external mentorship support at the start to ensure improved capacity among local mentors to provide mentorship among local district staff.

  • Voniati, Chris
    et al.
    Vrije Universiteit Brussel, Belgium.
    Doudaki, Vaia
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Carpentier, Nico
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media. Vrije Universiteit Brussel, Belgium.; Charles University, Prague, Czech Republic.
    Mapping community media organisations in Cyprus: A methodological reflection2018In: journal of alternative and community media, ISSN 2206-5857, Vol. 3, no 1, p. 17-35Article in journal (Refereed)
    Abstract [en]

    Identifying grassroots or ‘below-the-radar’ organisations, such as community media organisations, is a challenging task that is not always supported sufficiently by methodological literature. The objective of this article is to address this challenge by proposing a structured approach to mapping analysis: (1) driven by an (operational) definition of the social entity; (2) that allows for a population-based mapping process; (3) that uses a particular registration instrument (labelled a Mapping IndexCard, or MIC); (4) to process data from multiple sources; and (5) to analyse the information registered in these MICs. By zooming in on the only divided country of Europe – the island of Cyprus – this article then illustrates how to design and conduct a mapping research of community media organisations on a national scale. Other than giving an overview of the community media operating in Cyprus, this mapping exercise aims to provide a methodological guide for mapping civil society and  ‘below-the-radar’ organisations in general.

  • Sun, Xu
    et al.
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Zhang, Ganlin
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Nian, Jiayun
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.;Beijing Univ Chinese Med, Sch Grad, Beijing, Peoples R China..
    Yu, Mingwei
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Chen, Shijian
    Guangxi Med Univ, Dept Neurol, Affiliated Hosp 4, Liuzhou, Peoples R China..
    Zhang, Yi
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Yang, Guowang
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Yang, Lin
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Cheng, Peiyu
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Yan, Chen
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.;Beijing Univ Chinese Med, Sch Grad, Beijing, Peoples R China..
    Ma, Yunfei
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Meng, Hui
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.;Beijing Univ Chinese Med, Sch Grad, Beijing, Peoples R China..
    Wang, Xiaomin
    Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Li, Jin-Ping
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China..
    Elevated heparanase expression is associated with poor prognosis in breast cancer: a study based on systematic review and TCGA data2017In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 8, no 26, p. 43521-43535Article, review/survey (Refereed)
    Abstract [en]

    Heparanase promotes tumorigenesis, angiogenesis, and metastasis. Here, we conducted a study based on systematic review and the Cancer Genome Atlas (TCGA) data that examined heparanase expression in clinical samples to determine its prognostic value. According to the meta-analysis and TCGA data, we found that heparanase expression was up-regulated in most breast cancer specimens, and elevated heparanase expression was associated with increased lymph node metastasis, larger tumor size, higher histological grade, and poor survival. These results suggest that targeting heparanase might improve treatments for breast cancer patients.

  • Moustakas, Aristidis
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwig Institute for Cancer Research. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Garcia de Herreros, Antonio
    Inst Hosp del Mar Invest Med, Canc Res Program, Barcelona, Spain.;Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain..
    Epithelial-mesenchymal transition in cancer2017In: Molecular Oncology, ISSN 1574-7891, E-ISSN 1878-0261, Vol. 11, no 7, p. 715-717Article in journal (Other academic)
  • Sigrén, Peter
    University of Borås.
    Studentbarometern 20172018Report (Other academic)
    Abstract [sv]

    Studentbarometern omfattar två enskilda enkäter varav enkät I mäter åtta index genom 46 frågeställningar, ett index som avser upplevd stress (9 frågeställningar) samt ett index som avser hur nöjda studenterna är med att ha valt Högskolan i Borås för sina studier (3 frågeställningar). De åtta index som mäter utbildningsrelaterade områden är: utveckling av analytiska förmågor/färdigheter; pedagogisk kvalitet i undervisningen; huruvida kursvärderingar genomförs och diskuteras; om studentsamar­bete, i form av om grupparbeten leder till att studenterna utvecklar analy­tiska förmågor/färdigheter; hur informationen inför kursstart fungerar; att våga ge kritik utan att bli sämre behandlad; hur kravnivån upplevs på utbildningen; hur det administrativa stödet upplevs inom akademier och sektioner.

    Enkät II har sitt fokus på områden som hållbar utveckling; lika villkor; biblioteksverksamheten; studenthälsan samt Studentkårens arbete. 

  • Ólafsdóttir, Steingerður
    et al.
    Marniemi, Annikka
    Andersen, Morten C.
    Berg, Christina
    Prell, Hillevi
    Gísladóttir, Elva
    Helleve, Arnfinn
    Monitoring food marketing to children: A joint Nordic monitoring protocol for marketing of foods and beverages high in fat, salt and sugar (HFSS) towards children and young people2018Book (Other academic)
    Abstract [en]

    The protocol describes methods for how to monitor marketing of foods and beverages high in fat, salt and sugar towards children and young people at a given time as cross-sectional studies, as well as allowing for monitoring of trends. The data provided could also be used for evaluation purposes, for instance providing relevant data for evaluating regulation practices and schemes in the respective countries; to study advertising and marketing practices, contents and forms over time. In addition to being a tool for monitoring purposes within each country, the protocol will also enable comparisons between the Nordic countries by establishing a joint understanding on how each marketing channel should be monitored. The protocol has been developed as a Nordic project between representatives and experts from Iceland, Finland, Sweden, Denmark and Norway together with international experts.

  • Dølvik, Jon Erik
    et al.
    Jesnes, Kristin
    Nordic labour markets and the sharing economy: – Report from a pilot project2018Book (Refereed)
    Abstract [en]

    This report presents a preliminary knowledge status about implications of the sharing economy for labour markets and employment relations in the Nordic countries. It also reviews how the Nordic countries and their social partners approach the sharing economy and issues relating, amongst other, to its legality, regulation, taxation, and terms of competition. There is so far scant supply of statistics, data and research in this field. The employment potentials and consequences of the sharing economy will, amongst other, depend on the governments’ and the organized actors’ responses to these challenges. Currently, all the actors seem to be in a phase of knowledge gathering and deliberation of possible policy options, cautiously avoiding taking steps that might obstruct the development of the sharing economy.

  • Beale, Colin
    et al.
    Department of Biology, University of York, Heslington, York, UK.
    Courtney Mustaphi, Colin
    York Institute for Tropical Ecosystems, Environment Department, University of York, Heslington, York, UK.
    Morrison, Thomas
    Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK.
    Archibald, Sally
    Centre for African Ecology, School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Natural Resources and the Environment, CSIR, Pretoria, South Africa.
    Anderson, T. Michael
    Department of Biology, Wake Forest University, Winston-Salem, North Carolina, USA.
    Dobson, Andrew
    Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
    Donaldson, Jason
    Centre for African Ecology, School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Johannesburg, South Africa.
    Hempson, Gaeth
    Centre for African Ecology, School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Johannesburg, South Africa.; South African Environmental Observation Network (SAEON), Ndlovu Node, Phalaborwa, Kruger National Park, South Africa.
    Probert, James
    Department of Earth, Ocean & Ecological Sciences, University of Liverpool, Liverpool, UK.
    Parr, Catherine
    Centre for African Ecology, School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Earth, Ocean & Ecological Sciences, University of Liverpool, Liverpool, UK.; Department of Zoology & Entomology, University of Pretoria, Pretoria, South Africa.
    Pyrodiversity interacts with rainfall to increase bird andmammal richness in African savannas2018In: Ecology Letters, ISSN 1461-023X, E-ISSN 1461-0248Article in journal (Refereed)
    Abstract [en]

    Fire is a fundamental process in savannas and is widely used for management. Pyrodiversity, variation in local fire characteristics, has been proposed as a driver of biodiversity although empirical evidence is equivocal. Using a new measure of pyrodiversity (Hempsonet al.), we undertook the first continent-wide assessment of how pyrodiversity affects biodiversity in protected areas across African savannas. The influence of pyrodiversity on bird and mammal species richness varied with rainfall: strongest support for a positive effect occurred in wet savannas (>650 mm/year), where species richness increased by 27% for mammals and 40% for birds in the most pyrodiverse regions. Range-restricted birds were most increased by pyrodiversity, suggesting the diversity of fire regimes increases the availability of rare niches. Our findings are significant because they explain the conflicting results found in previous studies of savannas. We argue that managing savanna landscapes to increase pyrodiversity is especially important in wet savannas.

  • Suh, Alexander
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology. University of Münster, Institute of Experimental Pathology (ZMBE).
    Bachg, Sandra
    University of Münster, Institute of Experimental Pathology (ZMBE).
    Donnellan, Stephen
    South Australian Museum, Adelaide; The University of Adelaide, School of Biological Sciences.
    Joseph, Leo
    National Research Collections Australia, CSIRO, Australian National Wildlife Collection.
    Brosius, Jürgen
    University of Münster, Institute of Experimental Pathology (ZMBE); Brandenburg Medical School (MHB).
    Kriegs, Jan Ole
    University of Münster, Institute of Experimental Pathology (ZMBE); Westfälisches Landesmuseum mit Planetarium, LWL-Museum für Naturkunde.
    Schmitz, Jürgen
    University of Münster, Institute of Experimental Pathology (ZMBE).
    De-novo emergence of SINE retroposons during the early evolution of passerine birds2017In: Mobile DNA, ISSN 1759-8753, E-ISSN 1759-8753, Vol. 8, article id 21Article in journal (Refereed)
    Abstract [en]

    Background: Passeriformes ("perching birds" or passerines) make up more than half of all extant bird species. The genome of the zebra finch, a passerine model organism for vocal learning, was noted previously to contain thousands of short interspersed elements (SINEs), a group of retroposons that is abundant in mammalian genomes but considered largely inactive in avian genomes.

    Results: Here we resolve the deep phylogenetic relationships of passerines using presence/absence patterns of SINEs. The resultant retroposon-based phylogeny provides a powerful and independent corroboration of previous sequence-based analyses. Notably, SINE activity began in the common ancestor of Eupasseres (passerines excluding the New Zealand wrens Acanthisittidae) and ceased before the rapid diversification of oscine passerines (suborder Passeri - songbirds). Furthermore, we find evidence for very recent SINE activity within suboscine passerines (suborder Tyranni), following the emergence of a SINE via acquisition of a different tRNA head as we suggest through template switching.

    Conclusions: We propose that the early evolution of passerines was unusual among birds in that it was accompanied by de-novo emergence and activity of SINEs. Their genomic and transcriptomic impact warrants further study in the light of the massive diversification of passerines.

  • Molochkov, Alexander
    et al.
    Far Eastern Fed Univ, Lab Phys Living Matter, Sukhanova 8, Vladivostok 690950, Russia..
    Begun, Alexander
    Far Eastern Fed Univ, Lab Phys Living Matter, Sukhanova 8, Vladivostok 690950, Russia..
    Niemi, Antti
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics. Univ Tours, Lab Math & Phys Theor, Federat Denis Poisson, France.; Beijing Inst Technol, Dept Phys, Beijing, Peoples R China..
    Gauge symmetries and structure of proteins2017In: XIITH QUARK CONFINEMENT AND THE HADRON SPECTRUM / [ed] Foka, Y Brambilla, N Kovalenko, V, E D P SCIENCES , 2017, article id UNSP 04004Conference paper (Refereed)
    Abstract [en]

    We discuss the gauge field theory approach to protein structure study, which allows a natural way to introduce collective degrees of freedom and nonlinear topological structures. Local symmetry of proteins and its breaking in the medium is considered, what allows to derive Abelian Higgs model of protein backbone, correct folding of which is defined by gauge symmetry breaking due hydrophobic forces. Within this model structure of protein backbone is defined by superposition of one-dimensional topological solitons (kinks), what allows to reproduce the three-dimensional structure of the protein backbone with precision up to 1A and to predict its dynamics.

  • Bunker, Aditi
    et al.
    Sewe, Maquins Odhiambo
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Sié, Ali
    Rocklöv, Joacim
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Sauerborn, Rainer
    Excess burden of non-communicable disease years of life lost from heat in rural Burkina Faso: a time series analysis of the years 2000-20102017In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 7, no 11, article id e018068Article in journal (Refereed)
    Abstract [en]

    Objectives: Investigate the association of heat exposure on years of life lost (YLL) from non-communicable diseases (NCD) in Nouna, Burkina Faso, between 2000 and 2010.

    Design: Daily time series regression analysis using distributed lag non-linear models, assuming a quasi-Poisson distribution of YLL.

    Setting: Nouna Health and Demographic Surveillance System, Kossi Province, Rural Burkina Faso.

    Participants: 18 367 NCD-YLL corresponding to 790 NCD deaths recorded in the Nouna Health and Demographic Surveillance Site register over 11 years.

    Main outcome measure: Excess mean daily NCD-YLL were generated from the relative risk of maximum daily temperature on NCD-YLL, including effects delayed up to 14 days.

    Results: Daily average NCD-YLL were 4.6, 2.4 and 2.1 person-years for all ages, men and women, respectively. Moderate 4-day cumulative rise in maximum temperature from 36.4 degrees C (50th percentile) to 41.4 degrees C (90th percentile) resulted in 4.44 (95% CI 0.24 to 12.28) excess daily NCDYLL for all ages, rising to 7.39 (95% CI 0.32 to 24.62) at extreme temperature (42.8 degrees C; 99th percentile). The strongest health effects manifested on the day of heat exposure (lag 0), where 0.81 (95% CI 0.13 to 1.59) excess mean NCD-YLL occurred daily at 41.7 degrees C compared with 36.4 degrees C, diminishing in statistical significance after 4 days. At lag 0, daily excess mean NCD-YLL were higher for men, 0.58 (95% CI 0.11 to 1.15) compared with women, 0.15 (95% CI -0.25 to 9.63) at 41.7 degrees C vs 36.4 degrees C.

    Conclusion: Premature death from NCD was elevated significantly with moderate and extreme heat exposure. These findings have important implications for developing adaptation and mitigation strategies to reduce ambient heat exposure and preventive measures for limiting NCD in Africa.

  • Eriksson, Jörgen
    et al.
    Lund University.
    Lagvik, Christer
    Uppsala University, University Library.
    Nolin, Emma
    Lund University.
    Moving towards open science? Conference report: the 9th Conference on Open Access Scholarly Publishing, Lisbon, September 20-21, 20172017In: Nordic Perspectives on Open Science, ISSN 2464-1839, Vol. 1Article in journal (Other academic)
    Abstract [en]

    The Conference on Open Access Scholarly Publishing, COASP, is held annually with the aim of reaching professional publishing organizations, independent publishers and university presses, as well as librarians, university administrators and other stakeholders. Here, we outline some themes and highlights from this year´s conference.

  • Dong, Zhihua
    et al.
    KTH Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden..
    Schonecker, Stephan
    KTH Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden..
    Chen, Dengfu
    Chongqing Univ, Coll Mat Sci & Engn, Chongqing 400030, Peoples R China..
    Li, Wei
    KTH Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden..
    Long, Mujun
    Chongqing Univ, Coll Mat Sci & Engn, Chongqing 400030, Peoples R China..
    Vitos, Levente
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. KTH Royal Inst Technol, Dept Mat Sci & Engn, Appl Mat Phys, SE-10044 Stockholm, Sweden.;Wigner Res Ctr Phys, Res Inst Solid State Phys & Opt, POB 49, H-1525 Budapest, Hungary..
    Elastic properties of paramagnetic austenitic steel at finite temperature: Longitudinal spin fluctuations in multicomponent alloys2017In: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 96, no 17, article id 174415Article in journal (Refereed)
    Abstract [en]

    We propose a first-principles framework for longitudinal spin fluctuations (LSFs) in disordered paramagnetic (PM) multicomponent alloy systems and apply it to investigate the influence of LSFs on the temperature dependence of two elastic constants of PM austenitic stainless steel Fe15Cr15Ni. The magnetic model considers individual fluctuating moments in a static PM medium with first-principles-derived LSF energetics in conjunction with describing chemical disorder and randomness of the transverse magnetic component in the single-site alloy formalism and disordered local moment (DLM) picture. A temperature-sensitive mean magnetic moment is adopted to accurately represent the LSF state in the elastic-constant calculations. We make evident that magnetic interactions between an LSF impurity and the PM medium are weak in the present steel alloy. This allows gaining accurate LSF energetics and mean magnetic moments already through a perturbation from the static DLM moments instead of a tedious self-consistent procedure. We find that LSFs systematically lower the cubic shear elastic constants c' and c(44) by similar to 6 GPa in the temperature interval 300-1600 K, whereas the predominant mechanism for the softening of both elastic constants with temperature is the magneto-volume coupling due to thermal lattice expansion. We find that non-negligible local magnetic moments of Cr and Ni are thermally induced by LSFs, but they exert only a small influence on the elastic properties. The proposed framework exhibits high flexibility in accurately accounting for finite-temperature magnetism and its impact on the mechanical properties of PM multicomponent alloys.

  • Cornils, L.
    et al.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany..
    Kamlapure, A.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany..
    Zhou, L.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany.;Max Planck Inst Solid State Res, D-70569 Stuttgart, Germany..
    Pradhan, Saurabh
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Khajetoorians, A. A.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany.;Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands..
    Fransson, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Wiebe, J.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany..
    Wiesendanger, R.
    Univ Hamburg, Dept Phys, D-20355 Hamburg, Germany..
    Spin-Resolved Spectroscopy of the Yu-Shiba-Rusinov States of Individual Atoms2017In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 119, no 19, article id 197002Article in journal (Refereed)
    Abstract [en]

    A magnetic atom in a superconducting host induces so-called Yu-Shiba-Rusinov (YSR) bound states inside the superconducting energy gap. By combining spin-resolved scanning tunneling spectroscopy with simulations we demonstrate that the pair of peaks associated with the YSR states of an individual Fe atom coupled to an oxygen-reconstructed Ta surface gets spin polarized in an external magnetic field. As theoretically predicted, the electron and hole parts of the YSR states have opposite signs of spin polarizations which keep their spin character when crossing the Fermi level through the quantum phase transition. The simulation of a YSR state right at the Fermi level reveals zero spin polarization which can be used to distinguish such states from Majorana zero modes in chains of YSR atoms.

  • Garousi, Javad
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Lindbo, Sarah
    KTH Royal Inst Technol, Sch Biotechnol, Div Prot Technol, Stockholm, Sweden..
    Mitran, Bogdan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Buijs, Jos
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Vorobyeva, Anzhelika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Orlova, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Tolmachev, Vladimir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
    Hober, Sophia
    KTH Royal Inst Technol, Sch Biotechnol, Div Prot Technol, Stockholm, Sweden..
    Comparative evaluation of tumor targeting using the anti-HER2 ADAPT scaffold protein labeled at the C-terminus with indium-111 or technetium-99m2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 14780Article in journal (Refereed)
    Abstract [en]

    ABD-Derived Affinity Proteins (ADAPTs) is a novel class of engineered scaffold proteins derived from an albumin-binding domain of protein G. The use of ADAPT6 derivatives as targeting moiety have provided excellent preclinical radionuclide imaging of human epidermal growth factor 2 (HER2) tumor xenografts. Previous studies have demonstrated that selection of nuclide and chelator for its conjugation has an appreciable effect on imaging properties of scaffold proteins. In this study we performed a comparative evaluation of the anti-HER2 ADAPT having an aspartate-glutamate-alanine-valine-aspartate-alanine-asparagine-serine (DEAVDANS) N-terminal sequence and labeled at C-terminus with (99)mTc using a cysteine-containing peptide based chelator, glycine-serine-serine-cysteine (GSSC), and a similar variant labeled with In-111 using a maleimido derivative of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator. Both (99)mTc-DEAVDANS-ADAPT6-GSSC and In-111-DEAVDANS-ADAPT6-GSSC-DOTA accumulated specifically in HER2-expressing SKOV3 xenografts. The tumor uptake of both variants did not differ significantly and average values were in the range of 19-21% ID/g. However, there was an appreciable variation in uptake of conjugates in normal tissues that resulted in a notable difference in the tumor-to-organ ratios. The In-111-DOTA label provided 2-6 fold higher tumor-to-organ ratios than (99)mTc-GSSC and is therefore the preferable label for ADAPTs.

  • Bah, Ibrahima
    et al.
    Univ Calif San Diego, La Jolla, USA; Johns Hopkins Univ, Baltimore, USA.
    Passias, Achilleas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Tomasiello, Alessandro
    Univ Milano Bicocca, Milan, Italy; INFN, Milan, Italy.
    AdS(5) compactifications with punctures in massive IIA supergravity2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 11, article id 050Article in journal (Refereed)
    Abstract [en]

    We find AdS(5) solutions holographically dual to compactifications of six-dimensional N=(1,0) supersymmetric field theories on Riemann surfaces with punctures. We simplify a previous analysis of supersymmetric AdS(5) IIA solutions, and with a suitable Ansatz we find explicit solutions organized in three classes, where an O8-D8 stack, D6- and D4-branes are simultaneously present, localized and partially localized. The D4-branes are smeared over the Riemann surface and this is interpreted as the presence of a uniform distribution of punctures. For the first class we identify the corresponding six-dimensional theory as an E-string theory coupled to a quiver gauge theory. The second class of solutions lacks D6-branes and its central charge scales as n(5/2), suggesting a five-dimensional origin for the dual field theory. The last class has elements of the previous two.

  • Aaboud, M.
    et al.
    Université Mohamed Premier, Faculté des Sciences; LPTPM, Oujda.
    Bergeås, Elin Kuutmann
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, M.F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, M.U.F.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, P.H.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva.
    Search for a scalar partner of the top quark in the jets plus missing transverse momentum final state at √s=13 TeV with the ATLAS detector2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 12, article id 085Article in journal (Refereed)
    Abstract [en]

    A search for pair production of a scalar partner of the top quark in events with four or more jets plus missing transverse momentum is presented. An analysis of 36.1 fb(-1) of root s = 13 TeV proton-proton collisions collected using the ATLAS detector at the LHC yields no significant excess over the expected Standard Model background. To interpret the results a simplified supersymmetric model is used where the top squark is assumed to decay via (t) over tilde (1) -> t((*)) (chi) over tilde (0)(1) and (t) over tilde (1) -> b (chi) over tilde (+/-)(1) -> bW((*)) (chi) over tilde (0)(1), where (chi) over tilde (0)(1) ((chi) over tilde (+/-)(1) denotes the lightest neutralino (chargino). Exclusion limits are placed in terms of the top-squark and neutralino masses. Assuming a branching ratio of 100% to t (chi) over tilde (0)(1), top-squark masses in the range 450-1000 GeV are excluded for (chi) over tilde (0)(1) masses below 160 GeV. In the case where m((t) over tilde1) similar to m(t) + m((chi) over tilde 10), top-squark masses in the range 235-590 GeV are excluded.

  • Jabs, Verena
    et al.
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Edlund, Karolina
    Dortmund Univ, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany..
    Koenig, Helena
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Grinberg, Marianna
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Madjar, Katrin
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Rahnenfuehrer, Joerg
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Ekman, Simon
    Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden..
    Bergkvist, Michael
    Gavle Cent Hosp, Dept Oncol, Gavle, Sweden..
    Holmberg, Lars
    Reg Canc Ctr Uppsala Orebro, Uppsala, Sweden.;Kings Coll London, Fac Life Sci & Med, Div Canc Studies, London, England..
    Ickstadt, Katja
    TU Dortmund Univ, Fac Stat, Dortmund, Germany..
    Botling, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
    Hengstler, Jan G.
    Dortmund Univ, Leibniz Res Ctr Working Environm & Human Factors, Dortmund, Germany..
    Micke, Patrick
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
    Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 11, article id e0187246Article in journal (Refereed)
    Abstract [en]

    Non-small cell lung cancer (NSCLC) represents a genomically unstable cancer type with extensive copy number aberrations. The relationship of gene copy number alterations and subsequent mRNA levels has only fragmentarily been described. The aim of this study was to conduct a genome-wide analysis of gene copy number gains and corresponding gene expression levels in a clinically well annotated NSCLC patient cohort (n = 190) and their association with survival. While more than half of all analyzed gene copy number-gene expression pairs showed statistically significant correlations (10,296 of 18,756 genes), high correlations, with a correlation coefficient >0.7, were obtained only in a subset of 301 genes (1.6%), including KRAS, EGFR and MDM2. Higher correlation coefficients were associated with higher copy number and expression levels. Strong correlations were frequently based on few tumors with high copy number gains and correspondingly increased mRNA expression. Among the highly correlating genes, GO groups associated with posttranslational protein modifications were particularly frequent, including ubiquitination and neddylation. In a meta-analysis including 1,779 patients we found that survival associated genes were overrepresented among highly correlating genes (61 of the 301 highly correlating genes, FDR adjusted p<0.05). Among them are the chaperone CCT2, the core complex protein NUP107 and the ubiquitination and neddylation associated protein CAND1. In conclusion, in a comprehensive analysis we described a distinct set of highly correlating genes. These genes were found to be overrepresented among survival-associated genes based on gene expression in a large collection of publicly available datasets.

  • Al-Douri, Yamur
    et al.
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Operation, Maintenance and Acoustics.
    Hamodi, Hussan
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Operation, Maintenance and Acoustics.
    Data imputing using genetic algorithms (GA): A case study of cost data for tunnel fans2017Conference paper (Refereed)
  • Ali, Abir Salwa
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology.
    Grönberg, Malin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology.
    Federspiel, Birgitte
    Rigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark.
    Scoazec, Jean-Yves
    Inst Gustave Roussy, Villejuif, France.
    Hjortland, Geir Olav
    Univ Oslo, Oslo, Norway.
    Gronbaek, Henning
    Aarhus Univ Hosp, Aarhus, Denmark.
    Ladekarl, Morten
    Aarhus Univ Hosp, Aarhus, Denmark.
    Langer, Seppo W.
    Rigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark.
    Welin, Staffan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology.
    Vestermark, Lene Weber
    Odense Univ Hosp, Odense, Denmark.
    Arola, Johanna
    Univ Helsinki, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland.
    Osterlund, Pia
    Univ Helsinki, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland; Tampere Univ Hosp, Tampere, Finland.
    Knigge, Ulrich
    Univ Copenhagen, Rigshosp, Copenhagen, Denmark.
    Sorbye, Halfdan
    Haukeland Hosp, Bergen, Norway; Univ Bergen, Bergen, Norway.
    Grimelius, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Tiensuu Janson, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrin Oncology. Uppsala Univ, Sect Endocrine Oncol, Dept Med Sci, Uppsala, Sweden..
    Expression of p53 protein in high-grade gastroenteropancreatic neuroendocrine carcinoma2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 11, article id e0187667Article in journal (Refereed)
    Abstract [en]

    Background Gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs) are aggressive, rapidly proliferating tumors. Therapeutic response to current chemotherapy regimens is usually short lasting. The aim of this study was to examine the expression and potential clinical importance of immunoreactive p53 protein in GEP-NEC. Materials and methods Tumor tissues from 124 GEP-NEC patients with locally advanced or metastatic disease treated with platinum-based chemotherapy were collected from Nordic centers and clinical data were obtained from the Nordic NEC register. Tumor proliferation rate and differentiation were re-evaluated. All specimens were immunostained for p53 protein using a commercially available monoclonal antibody. Kaplan-Meier curves and cox regression analyses were used to assess progression-free survival (PFS) and overall survival (OS). Results All tumor tissues were immunoreactive for either one or both neuroendocrine biomarkers (chromogranin A and synaptophysin) and Ki67 index was >20% in all cases. p53 immunoreactivity was only shown in 39% of the cases and was not found to be a prognostic marker for the whole cohort. However, p53 immunoreactivity was correlated with shorter PFS in patients with colorectal tumors (HR = 2.1, p = 0.03) in a univariate analysis as well as to poorer PFS (HR = 2.6, p = 0.03) and OS (HR = 3.4, p = 0.02) in patients with colorectal tumors with distant metastases, a correlation which remained significant in the multivariate analyses. Conclusion In this cohort of GEP-NEC patients, p53 expression could not be correlated with clinical outcome. However, in patients with colorectal NECs, p53 expression was correlated with shorter PFS and OS. Further studies are needed to establish the role of immunoreactive p53 as a prognostic marker for GEP-NEC patients.

  • Pool, Sandra
    et al.
    Univ Zurich, Zurich, Switzerland.
    Vis, Marc J. P.
    Univ Zurich, Zurich, Switzerland.
    Knight, Rodney R.
    US Geol Survey, Nashville, USA.
    Seibert, Jan
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, LUVAL. Univ Zurich, Zurich, Switzerland; Stockholm Univ, Stockholm, Sweden.
    Streamflow characteristics from modeled runoff time series importance of calibration criteria selection2017In: Hydrology and Earth System Sciences, ISSN 1027-5606, E-ISSN 1607-7938, Vol. 21, no 11, p. 5443-5457Article in journal (Refereed)
    Abstract [en]

    Ecologically relevant streamflow characteristics (SFCs) of ungauged catchments are often estimated from simulated runoff of hydrologic models that were originally calibrated on gauged catchments. However, SFC estimates of the gauged donor catchments and subsequently the ungauged catchments can be substantially uncertain when models are calibrated using traditional approaches based on optimization of statistical performance metrics (e.g., Nash-Sutcliffe model efficiency). An improved calibration strategy for gauged catchments is therefore crucial to help reduce the uncertainties of estimated SFCs for ungauged catchments. The aim of this study was to improve SFC estimates from modeled runoff time series in gauged catchments by explicitly including one or several SFCs in the calibration process. Different types of objective functions were defined consisting of the Nash-Sutcliffe model efficiency, single SFCs, or combinations thereof. We calibrated a bucket-type runoff model (HBV-Hydrologiska Byrans Vattenavdelning-model) for 25 catchments in the Tennessee River basin and evaluated the proposed calibration approach on 13 ecologically relevant SFCs representing major flow regime components and different flow conditions. While the model generally tended to underestimate the tested SFCs related to mean and high-flow conditions, SFCs related to low flow were generally overestimated. The highest estimation accuracies were achieved by a SFC-specific model calibration. Estimates of SFCs not included in the calibration process were of similar quality when comparing a multi-SFC calibration approach to a traditional model efficiency calibration. For practical applications, this implies that SFCs should preferably be estimated from targeted runoff model calibration, and modeled estimates need to be carefully interpreted.

  • Liao, Qinghua
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Pabis, Anna
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular biophysics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Strodel, Birgit
    Forschungszentrum Julich, Julich, Germany; Heinrich Heine Univ Dusseldorf, Dusseldorf, Germany.
    Kamerlin, Shina Caroline Lynn
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Biology.
    Extending the Nonbonded Cationic Dummy Model to Account for Ion-Induced Dipole Interactions2017In: Journal of Physical Chemistry Letters, ISSN 1948-7185, E-ISSN 1948-7185, Vol. 8, no 21, p. 5408-5414Article in journal (Refereed)
    Abstract [en]

    Modeling metalloproteins often requires classical molecular dynamics (MD) simulations in order to capture their relevant motions, which in turn necessitates reliable descriptions of the metal centers involved. One of the most successful approaches to date is provided by the "cationic dummy model", where the positive charge of the metal ion is transferred toward dummy particles that are bonded to the central metal ion in a predefined coordination geometry. While this approach allows for ligand exchange, and captures the correct electrostatics as demonstrated for different divalent metal ions, current dummy models neglect ion-induced dipole interactions. In the present work, we resolve this weakness by taking advantage of the recently introduced 12-6-4 type Lennard-Jones potential to include ion-induced dipole interactions. We revise our previous dummy model for Mg2+ and demonstrate that the resulting model can simultaneously reproduce the experimental solvation free energy and metal ligand distances without the need for artificial restraints or bonds. As ion-induced dipole interactions become particularly important for highly charged metal ions, we develop dummy models for the biologically relevant ions Al3+, Fe3+, and Cr3+. Finally, the effectiveness of our new models is demonstrated in MD simulations of several diverse (and highly challenging to simulate) metalloproteins.

  • Ablikim, M.
    et al.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Achasov, M. N.
    GI Budker Inst Nucl Phys SB RAS BINP, Novosibirsk 630090, Russia.;Novosibirsk State Univ, Novosibirsk 630090, Russia. NRC Kurchatov Inst, PNPI, Gatchina 188300, Russia..
    Ahmed, S.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Ai, X. C.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    AlbayraK, O.
    Carnegie Mellon Univ, Pittsburgh, PA 15213 USA..
    Albrecht, M.
    Bochum Ruhr Univ, D-44780 Bochum, Germany..
    Ambrose, D. J.
    Univ Rochester, 601 Elmwood Ave, Rochester, NY 14627 USA. Univ Sci & Technol Liaoning, Anshan 114051, Peoples R China..
    Amoroso, A.
    INFN, Sez Ferrara, I-44122 Ferrara, Italy.;Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    An, F. F.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    An, Q.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Bai, J. Z.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Ferroli, R. Baldini
    INFN, Lab Nazl Frascati, I-00044 Frascati, Italy. INFN, I-06100 Perugia, Italy. Univ Perugia, I-06100 Perugia, Italy.;INFN, Sez Ferrara, I-44122 Ferrara, Italy..
    Ban, Y.
    Peking Univ, Beijing 100871, Peoples R China..
    Bennett, D. W.
    Indiana Univ, Bloomington, IN 47405 USA..
    Bennett, J. V.
    Carnegie Mellon Univ, Pittsburgh, PA 15213 USA..
    Berger, N.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Bertani, M.
    INFN, Lab Nazl Frascati, I-00044 Frascati, Italy. INFN, I-06100 Perugia, Italy. Univ Perugia, I-06100 Perugia, Italy..
    Bettoni, D.
    INFN, Sez Ferrara, I-44122 Ferrara, Italy..
    Bian, J. M.
    Univ Minnesota, Minneapolis, MN 55455 USA..
    Bianchi, F.
    Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Boger, E.
    Joint Inst Nucl Res, Moscow 141980, Russia.;Moscow Inst Phys & Technol, Moscow 141700, Russia..
    Boyko, I.
    Joint Inst Nucl Res, Moscow 141980, Russia..
    Briere, R. A.
    Carnegie Mellon Univ, Pittsburgh, PA 15213 USA..
    Cai, H.
    Wuhan Univ, Wuhan 430072, Hubei, Peoples R China..
    Cai, X.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Cakir, O.
    Ankara Univ, TR-06100 Ankara, Turkey..
    Calcaterra, A.
    INFN, Lab Nazl Frascati, I-00044 Frascati, Italy. INFN, I-06100 Perugia, Italy. Univ Perugia, I-06100 Perugia, Italy..
    Cao, G. F.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Cetin, S. A.
    Istanbul Bilgi Univ, TR-34060 Istanbul, Turkey. Uludag Univ, TR-16059 Bursa, Turkey. Near East Univ, Mersin 10, Nicosia, North Cyprus, Turkey..
    Chai, J.
    Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Chang, J. F.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Chelkov, G.
    Joint Inst Nucl Res, Moscow 141980, Russia.;Moscow Inst Phys & Technol, Moscow 141700, Russia.;Tomsk State Univ, Funct Elect Lab, Tomsk 634050, Russia..
    Cheng, G.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Chen, H. S.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Chen, J. C.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Chen, M. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Chen, S.
    Univ Chinese Acad Sci, Beijing 100049, Peoples R China..
    Chen, S. J.
    Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China..
    Chen, X.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Chen, X. R.
    Lanzhou Univ, Lanzhou 730000, Gansu, Peoples R China..
    Chen, Y. B.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Chen, H. P.
    Huangshan Coll, Huangshan 245000, Peoples R China. Hunan Univ, Changsha 410082, Hunan, Peoples R China..
    Chu, X. K.
    Peking Univ, Beijing 100871, Peoples R China..
    Cibinetto, G.
    INFN, Sez Ferrara, I-44122 Ferrara, Italy..
    Dai, H. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Dai, J. P.
    Shanghai Jiao Tong Univ, Shanghai 200240, Peoples R China..
    Dbeyssi, A.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Dedovich, D.
    Joint Inst Nucl Res, Moscow 141980, Russia..
    Deng, Z. Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Denig, A.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Denysenko, I.
    Joint Inst Nucl Res, Moscow 141980, Russia..
    Destefanis, M.
    Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    De Mori, F.
    Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Ding, Y.
    Liaoning Univ, Shenyang 110036, Liaoning, Peoples R China..
    Dong, C.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Dong, J.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Dong, L. Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Dong, M. Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Dou, Z. L.
    Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China..
    Du, S. X.
    Zhengzhou Univ, Zhengzhou 450001, Henan, Peoples R China..
    Duan, P. F.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Fan, J. Z.
    Tsinghua Univ, Beijing 100084, Peoples R China..
    Fang, J.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Fang, S. S.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Fang, X.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Fang, Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Farinelli, R.
    Univ Ferrara, I-44122 Ferrara, Italy..
    Fava, L.
    Univ Piemonte Orientale, I-15121 Alessandria, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Fedorov, O.
    Joint Inst Nucl Res, Moscow 141980, Russia..
    Feldbauer, F.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Felici, G.
    INFN, Lab Nazl Frascati, I-00044 Frascati, Italy. INFN, I-06100 Perugia, Italy. Univ Perugia, I-06100 Perugia, Italy..
    Feng, C. Q.
    Cent China Normal Univ, Wuhan 430079, Hubei, Peoples R China. China Ctr Adv Sci & Technol, Beijing 100190, Peoples R China. COMSATS Inst Informat Technol, Def Rd,Raiwind Rd, Lahore 54000, Pakistan.;Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Fioravanti, E.
    INFN, Sez Ferrara, I-44122 Ferrara, Italy..
    Fritsch, M.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany.;Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Fu, C. D.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Gao, Q.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Gao, X. L.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Gao, Y.
    Tsinghua Univ, Beijing 100084, Peoples R China..
    Gao, Z.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Garzia, I.
    INFN, Sez Ferrara, I-44122 Ferrara, Italy..
    Goetzen, K.
    GSI Helmholtzctr Heavy Ion Res GmbH, D-64291 Darmstadt, Germany..
    Gong, L.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Gong, W. X.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Gradl, W.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Greco, M.
    Univ Turin, I-10125 Turin, Italy..
    Gu, M. H.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Gu, Y. T.
    Guangxi Univ, Nanning 530004, Peoples R China..
    Guan, Y. H.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Guo, Q.
    Guo, L. B.
    Nanjing Normal Univ, Nanjing 210023, Jiangsu, Peoples R China..
    Guo, R. P.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Guo, Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Guo, Y. P.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Haddadi, Z.
    Univ Groningen, KVI CART, NL-9747 AA Groningen, Netherlands..
    Hafner, A.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Han, S.
    Wuhan Univ, Wuhan 430072, Hubei, Peoples R China..
    Hao, X. Q.
    Henan Normal Univ, Xinxiang 453007, Peoples R China. Henan Univ Sci & Technol, Luoyang 471003, Peoples R China..
    Harris, F. A.
    Univ Hawaii, Honolulu, HI 96822 USA..
    He, K. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Heinsius, F. H.
    Bochum Ruhr Univ, D-44780 Bochum, Germany..
    Held, T.
    Bochum Ruhr Univ, D-44780 Bochum, Germany..
    Heng, Y. K.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Holtmann, T.
    Bochum Ruhr Univ, D-44780 Bochum, Germany..
    Hou, Z. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Hu, C.
    Nanjing Normal Univ, Nanjing 210023, Jiangsu, Peoples R China..
    Hu, H. M.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Hu, J. F.
    Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Hu, T.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Hu, Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China..
    Huang, G. S.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Huang, J. S.
    Henan Normal Univ, Xinxiang 453007, Peoples R China. Henan Univ Sci & Technol, Luoyang 471003, Peoples R China..
    Huang, X. T.
    Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Huang, X. Z.
    Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China..
    Huang, Y.
    Nanjing Univ, Nanjing 210093, Jiangsu, Peoples R China..
    Huang, Z. L.
    Liaoning Univ, Shenyang 110036, Liaoning, Peoples R China..
    Hussain, T.
    Univ Punjab, Lahore 54590, Pakistan..
    Ji, Q.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Ji, Q. P.
    Henan Normal Univ, Xinxiang 453007, Peoples R China. Henan Univ Sci & Technol, Luoyang 471003, Peoples R China..
    Ji, X. B.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Ji, X. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Jiang, L. W.
    Wuhan Univ, Wuhan 430072, Hubei, Peoples R China..
    Jiang, X. S.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Jiang, X. Y.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Jiao, J. B.
    Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Jiao, Z.
    Huangshan Coll, Huangshan 245000, Peoples R China. Hunan Univ, Changsha 410082, Hunan, Peoples R China..
    Jin, D. P.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Jin, S.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Julin, A.
    Univ Minnesota, Minneapolis, MN 55455 USA..
    Kalantar-Nayestanaki, N.
    Univ Groningen, KVI CART, NL-9747 AA Groningen, Netherlands..
    Kang, X. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Kang, X. S.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Kavatsyuk, M.
    Univ Groningen, KVI CART, NL-9747 AA Groningen, Netherlands..
    Ke, B. C.
    Carnegie Mellon Univ, Pittsburgh, PA 15213 USA..
    Kiese, P.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Kliemt, R.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Kloss, B.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Kolcu, O. B.
    Istanbul Bilgi Univ, TR-34060 Istanbul, Turkey. Uludag Univ, TR-16059 Bursa, Turkey. Near East Univ, Mersin 10, Nicosia, North Cyprus, Turkey.;Istanbul Arel Univ, TR-34295 Istanbul, Turkey. Goethe Univ Frankfurt, D-60323 Frankfurt, Germany..
    Kopf, B.
    Bochum Ruhr Univ, D-44780 Bochum, Germany..
    Kornicer, M.
    Univ Hawaii, Honolulu, HI 96822 USA..
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kuhn, W.
    Justus Liebig Univ Giessen, Phys Inst 2, Heinrich Buff Ring 16, D-35392 Giessen, Germany..
    Lange, J. S.
    Justus Liebig Univ Giessen, Phys Inst 2, Heinrich Buff Ring 16, D-35392 Giessen, Germany..
    Lara, M.
    Indiana Univ, Bloomington, IN 47405 USA..
    Larin, P.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Leithoff, H.
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Leng, C.
    Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Li, Cui
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Li, Cheng
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Li, D. M.
    Zhengzhou Univ, Zhengzhou 450001, Henan, Peoples R China..
    Li, F.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Li, F. Y.
    Peking Univ, Beijing 100871, Peoples R China..
    Li, G.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Li, H. B.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Li, H. J.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Li, J. C.
    Li, Jin
    Seoul Natl Univ, Seoul 151747, South Korea..
    Li, K.
    Hangzhou Normal Univ, Hangzhou 310036, Zhejiang, Peoples R China.;Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Li, Lei
    Beijing Inst Petrochem Technol, Beijing 102617, Peoples R China..
    Li, P. R.
    Univ Chinese Acad Sci, Beijing 100049, Peoples R China..
    Li, Q. Y.
    Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Li, T.
    Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Li, W. D.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Li, W. G.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Li, X. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Li, X. N.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Li, X. Q.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Li, Y. B.
    Beihang Univ, Beijing 100191, Peoples R China..
    Li, Z. B.
    Sun Yat Sen Univ, Guangzhou 510275, Guangdong, Peoples R China..
    Liang, H.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Liang, Y. F.
    Sichuan Univ, Chengdu 610064, Sichuan, Peoples R China. Soochow Univ, Suzhou 215006, Peoples R China..
    Liang, Y. T.
    Justus Liebig Univ Giessen, Phys Inst 2, Heinrich Buff Ring 16, D-35392 Giessen, Germany..
    Liao, G. R.
    Guangxi Normal Univ, Guilin 541004, Peoples R China..
    Lin, D. X.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Liu, B.
    Shanghai Jiao Tong Univ, Shanghai 200240, Peoples R China..
    Liu, B. J.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, C. X.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, D.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Liu, F. H.
    Shanxi Univ, Taiyuan 030006, Shanxi, Peoples R China..
    Liu, Fang
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, Feng
    Liu, H. B.
    Guangxi Univ, Nanning 530004, Peoples R China..
    Liu, H. H.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, H. M.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, J.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, J. B.
    State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Liu, J. P.
    Wuhan Univ, Wuhan 430072, Hubei, Peoples R China..
    Liu, J. Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Liu, K.
    Tsinghua Univ, Beijing 100084, Peoples R China..
    Liu, K. Y.
    Liaoning Univ, Shenyang 110036, Liaoning, Peoples R China..
    Liu, L. D.
    Peking Univ, Beijing 100871, Peoples R China..
    Liu, P. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Liu, Q.
    Univ Chinese Acad Sci, Beijing 100049, Peoples R China..
    Liu, S. B.
    Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China. Univ South China, Hengyang 421001, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Liu, X.
    Lanzhou Univ, Lanzhou 730000, Gansu, Peoples R China..
    Liu, Y. B.
    Liu, Y. Y.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Liu, Z. A.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Liu, Zhiqing
    Johannes Gutenberg Univ Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Loehner, H.
    Univ Groningen, KVI CART, NL-9747 AA Groningen, Netherlands..
    Long, Y. F.
    Peking Univ, Beijing 100871, Peoples R China..
    Lou, X. C.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey.;Univ Texas Dallas, Richardson, TX 75083 USA..
    Lu, H. J.
    Huangshan Coll, Huangshan 245000, Peoples R China. Hunan Univ, Changsha 410082, Hunan, Peoples R China..
    Lu, J. G.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Lu, Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Lu, Y. P.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Luo, C. L.
    Nanjing Normal Univ, Nanjing 210023, Jiangsu, Peoples R China..
    Luo, M. X.
    Zhejiang Univ, Hangzhou 310027, Zhejiang, Peoples R China..
    Luo, T.
    Univ Hawaii, Honolulu, HI 96822 USA..
    Luo, X. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Lyu, X. R.
    Univ Chinese Acad Sci, Beijing 100049, Peoples R China..
    Ma, F. C.
    Liaoning Univ, Shenyang 110036, Liaoning, Peoples R China..
    Ma, H. L.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Ma, L. L.
    Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Ma, M. M.
    Ma, Q. M.
    Ma, T.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Ma, X. N.
    Nankai Univ, Tianjin 300071, Peoples R China..
    Ma, X. Y.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China..
    Ma, Y. M.
    Shandong Univ, Jinan 250100, Shandong, Peoples R China..
    Maas, F. E.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Maggiora, M.
    Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Malik, Q. A.
    Univ Punjab, Lahore 54590, Pakistan..
    Mao, Y. J.
    Peking Univ, Beijing 100871, Peoples R China..
    Mao, Z. P.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Marcello, S.
    Univ Turin, I-10125 Turin, Italy.;Ist Nazl Fis Nucl, I-10125 Turin, Italy..
    Messchendorp, J. G.
    Univ Groningen, KVI CART, NL-9747 AA Groningen, Netherlands..
    Mezzadri, G.
    Univ Ferrara, I-44122 Ferrara, Italy..
    Min, J.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Min, T. J.
    Inst High Energy Phys, Beijing 100049, Peoples R China..
    Mitchell, R. E.
    Indiana Univ, Bloomington, IN 47405 USA..
    Mo, X. H.
    Inst High Energy Phys, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China.;State Key Lab Particle Detect & Elect, Hefei 230026, Anhui, Peoples R China. Bogazici Univ, TR-34342 Istanbul, Turkey..
    Mo, Y. J.
    Cent China Normal Univ, Wuhan 430079, Hubei, Peoples R China. China Ctr Adv Sci & Technol, Beijing 100190, Peoples R China. COMSATS Inst Informat Technol, Def Rd,Raiwind Rd, Lahore 54000, Pakistan.;State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China..
    Morales, C. Morales
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Muchno, N. Yu.
    GI Budker Inst Nucl Phys SB RAS BINP, Novosibirsk 630090, Russia.;Novosibirsk State Univ, Novosibirsk 630090, Russia. NRC Kurchatov Inst, PNPI, Gatchina 188300, Russia..
    Muramatsu, H.
    Univ Minnesota, Minneapolis, MN 55455 USA..
    Musiol, P.
    Bochum Ruhr Univ, D-44780 Bochum, Germany..
    Nefedov, Y.
    Joint Inst Nucl Res, Moscow 141980, Russia..
    Nerling, F.
    Helmholtz Inst Mainz, Johann Joachim Becher Weg 45, D-55099 Mainz, Germany..
    Nikolaev, I. B.
    GI Budker Inst Nucl Phys SB RAS BINP, Novosibirsk 630090, Russia.;Novosibirsk State Univ, Novosibirsk 630090, Russia. NRC Kurchatov Inst, PNPI, Gatchina 188300, Russia..
    Ning, Z.
    Nisar, S.
    Niu, S. L.
    Niu, X. Y.
    Olsen, S. L.
    Ouyang, Q.
    Pacetti, S.
    Pan, Y.
    Patteri, P.
    Pelizaeus, M.
    Peng, H. P.
    Peters, K.
    Pettersson, J.
    Ping, J. L.
    Ping, R. G.
    Poling, R.
    Prasad, V.
    Qi, H. R.
    Qi, M.
    Qian, S.
    Qiao, C. F.
    Qin, L. Q.
    Qin, N.
    Qin, X. S.
    Qin, Z. H.
    Qiu, J. F.
    Rashid, K. H.
    Redmer, C. F.
    Ripka, M.
    Rong, G.
    Rosner, Ch.
    Ruan, X. D.
    Sarantsev, A.
    Savrie, M.
    Schnier, C.
    Schoenning, K.
    Schumann, S.
    Shan, W.
    Shao, M.
    Shen, C. P.
    Shen, P. X.
    Shen, X. Y.
    Shen, H. Y.
    Shi, M.
    Song, W. M.
    Song, X. Y.
    Sosio, S.
    Spataro, S.
    Sun, G. X.
    Sun, J. F.
    Sun, S. S.
    Sun, X. H.
    Sun, Y. J.
    Sun, Y. Z.
    Sun, Z. J.
    Sun, Z. T.
    Tang, C. J.
    Tang, X.
    Tapan, I.
    Thorndike, E. H.
    Tiemens, M.
    Uman, I.
    Varner, G. S.
    Wang, B.
    Wang, B. L.
    Wang, D.
    Wang, D. Y.
    Wang, K.
    Wang, L. L.
    Wang, L. S.
    Wang, M.
    Wang, P.
    Wang, P. L.
    Wang, W.
    Wang, W. P.
    Wang, X. F.
    Wang, Y.
    Wang, Y. D.
    Wang, Y. F.
    Wang, Y. Q.
    Wang, Z.
    Wang, Z. G.
    Wang, Z. H.
    Wang, Z. Y.
    Weber, T.
    Wei, D. H.
    Weidenkaff, P.
    Wen, S. P.
    Wiedner, U.
    Wolke, M.
    Wu, L. H.
    Wu, L. J.
    Wu, Z.
    Xia, L.
    Xia, L. G.
    Xia, Y.
    Xiao, D.
    Xiao, H.
    Xiao, Z. J.
    Xie, Y. G.
    Xiu, Q. L.
    Xui, G. F.
    Xu, J. J.
    Xu, L.
    Xu, Q. J.
    Xu, Q. N.
    Xu, X. P.
    Yan, L.
    Yan, W. B.
    Yan, W. C.
    Yan, Y. H.
    Yang, H. J.
    Yang, H. X.
    Yang, L.
    Yang, Y. X.
    Ye, M.
    Ye, M. H.
    Yin, J. H.
    You, Z. Y.
    Yu, B. X.
    Yu, C. X.
    Yu, J. S.
    Yuan, C. Z.
    Yuan, W. L.
    Yuan, Y.
    Yun, A.
    Zafar, A. A.
    Zallo, A.
    Zeng, Y.
    Zeng, Z.
    Zhang, B. X.
    Zhang, B. Y.
    Zhang, C.
    Zhang, C. C.
    Zhang, D. H.
    Zhang, H. H.
    Zhang, H. Y.
    Zhang, J.
    Zhang, J. J.
    Zhang, J. L.
    Zhang, J. Q.
    Zhang, J. W.
    Zhang, J. Y.
    Zhang, J. Z.
    Zhang, K.
    Zhang, L.
    Zhang, S. Q.
    Zhang, X. Y.
    Zhang, Y.
    Zhang, Y. H.
    Zhang, Y. N.
    Zhang, Y. T.
    Zhang, Yu
    Zhang, Z. H.
    Zhang, Z. P.
    Zhang, Z. Y.
    Zhao, G.
    Zhao, J. W.
    Zhao, J. Y.
    Zhao, J. Z.
    Zhao, Lei
    Zhao, Ling
    Zhao, M. G.
    Zhao, Q.
    Zhao, Q. W.
    Zhao, S. J.
    Zhao, T. C.
    Zhao, Y. B.
    Zhao, Z. G.
    Zhemchugov, A.
    Zheng, B.
    Zheng, J. P.
    Zheng, W. J.
    Zheng, Y. H.
    Zhong, B.
    Zhou, L.
    Zhou, X.
    Zhou, X. K.
    Zhou, X. R.
    Zhou, X. Y.
    Zhu, K.
    Zhu, K. J.
    Zhu, S.
    Zhu, S. H.
    Zhu, X. L.
    Zhu, Y. C.
    Zhu, Y. S.
    Zhu, Z. A.
    Zhuang, J.
    Zotti, L.
    Zou, B. S.
    Zou, J. H.
    Measurement of integrated luminosity and center-of-mass energy of data taken by BESIII at √s=2.125 GeV2017In: Chinese Physics C, High Energy Physics & Nuclear Physics, ISSN 1674-1137, E-ISSN 0899-9996, Vol. 41, no 11, article id 113001Article in journal (Refereed)
    Abstract [en]

    To study the nature of the state Y (2175), a dedicated data set of e(+)e(-) collision data was collected at the center-of-mass energy of 2.125 GeV with the BESIII detector at the BEPCII collider. By analyzing large-angle Bhabha scattering events, the integrated luminosity of this data set is determined to be 108.49 +/- 0.02 +/- 0.85 pb(-1), where the first uncertainty is statistical and the second one is systematic. In addition, the center-of-mass energy of the data set is determined with radiative dimuon events to be 2126.55 +/- 0.03 +/- 0.85 MeV, where the first uncertainty is statistical and the second one is systematic.

  • Grandi, Nicole
    et al.
    University of Cagliari, Cagliari, Italy.
    Cadeddu, Marta
    University of Cagliari, Cagliari, Italy.
    Pisano, Maria Paola
    University of Cagliari, Cagliari, Italy.
    Esposito, Francesca
    University of Cagliari, Cagliari, Italy.
    Blomberg, Jonas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology.
    Tramontano, Enzo
    University of Cagliari, Cagliari, Italy.
    Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion2017In: Mobile DNA, ISSN 1759-8753, E-ISSN 1759-8753, Vol. 8, article id 15Article in journal (Refereed)
    Abstract [en]

    About half of the human genome is constituted of transposable elements, including human endogenous retroviruses (HERV). HERV sequences represent the 8% of our genetic material, deriving from exogenous infections occurred millions of years ago in the germ line cells and being inherited by the offspring in a Mendelian fashion. HERV-K elements (classified as HML1-10) are among the most studied HERV groups, especially due to their possible correlation with human diseases. In particular, the HML10 group was reported to be upregulated in persistent HIV-1 infected cells as well as in tumor cells and samples, and proposed to have a role in the control of host genes expression. An individual HERV-K(HML10) member within the major histocompatibility complex C4 gene has even been studied for its possible contribution to type 1 diabetes susceptibility. Following a first characterization of the HML10 group at the genomic level, performed with the innovative software RetroTector, we have characterized in detail the 8 previously identified HML10 sequences present in the human genome, and an additional HML10 partial provirus in chromosome 1p22.2 that is reported here for the first time. Using a combined approach based on RetroTector software and a traditional Genome Browser Blat search, we identified a novel HERV-K(HML10) sequence in addition to the eight previously reported in the human genome GRCh37/hg19 assembly. We fully characterized the nine HML10 sequences at the genomic level, including their classification in two types based on both structural and phylogenetic characteristics, a detailed analysis of each HML10 nucleotide sequence, the first description of the presence of an Env Rec domain in the type II HML10, the estimated time of integration of individual members and the comparative map of the HML10 proviruses in non-human primates. We performed an unambiguous and exhaustive analysis of the nine HML10 sequences present in GRCh37/hg19 assembly, useful to increase the knowledge of the group's contribution to the human genome and laying the foundation for a better understanding of the potential physiological effects and the tentative correlation of these sequences with human pathogenesis.

  • Hedegaard Sørensen, Claus
    Swedish National Road and Transport Research Institute, Society, environment and transport, Mobility, actors and planning processes. K2.
    Å gjenoppfinne kollektivtrafikk i en tid med Smart mobilitet2018Conference paper (Other academic)
  • Public defence: 2018-03-10 10:00 Auditorium Minus, Uppsala
    Frisk, Pia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Surveys and services: The feasibility of conducting research in Swedish community pharmacies2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    For the past decades, there has been a shift in community pharmacy practice from dispensing and compounding towards provision of pharmacy services. Research is important to generate evidence for new services within pharmacy practice. Pharmacy practice research can be divided in two main themes: research related to pharmacy as a data source and to the pharmacy as the object of research, respectively.

    The purpose of this thesis is to increase the understanding of the conditions required for successful involvement of Swedish community pharmacy staff in pharmacy-based research, and to evaluate the data generated through a certain type of research: pharmacy-based patient surveys on drug utilization.

    Specific aims were to evaluate if there is a selection bias in drug utilization surveys conducted in Swedish community pharmacies, to explore the experiences of pharmacists either conducting the surveys or recruiting patients to research on adherence-promoting services, and to describe barriers and facilitators to conducting research in community pharmacies.

    Data were collected via pharmacy-based patient surveys, dispensing data, individual interviews, a cross-sectional staff survey and focus group interviews.

    In community pharmacy-based surveys or services research, with the dispensed drug as the trigger for inclusion, patients aged 75 years or older are underrepresented since they less often visit the pharmacy to redeem their prescriptions themselves. Due to their perceived workload, dispensing pharmacists sometimes avoid including patients perceived as complex due to age, polypharmacy or communication difficulties. These processes contribute to a healthy selection effect in both types of research and pharmacy services not reaching the patients in most need of support with their medication.

    The pharmacists were generally positive to conducting surveys and being involved in services research, but reported a perceived lack of sufficient communication and research skills, and a lack of time.

    Since competing commercial priorities hamper pharmacists’ research involvement, separate research funding is an important facilitator. For surveys to include all eligible patients, services to be relevant for both practice and patients and to target the patients in most need of support with their medication, research collaboration with healthcare, other professions and across pharmacies is also necessary.

  • Schönning, Karin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Li, Cui
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Future Perspectives on Baryon Form Factor Measurements with BES III2017In: Xiith Quark Confinement And The Hadron Spectrum / [ed] Foka, Y Brambilla, N Kovalenko, V, E D P SCIENCES , 2017, article id UNSP 12002Conference paper (Refereed)
    Abstract [en]

    The electromagnetic structure of hadrons, parameterised in terms of electromagnetic form factors, EMFF's, provide a key to the strong interaction. Nucleon EMFF's have been studied rigorously for more than 60 years but the new techniques and larger data samples available at modern facilities have given rise to a renewed interest for the field. Recently, the access to hyperon structure by hyperon time-like EMFF provides an additional dimension. The BEijing Spectrometer (BES III) at the Beijing Electron Positron Collider (BEPC-II) in China is the only running experiment where time-like baryon EMFF's can be studied in the e(+) e(-) -> BB reaction. The BES III detector is an excellent tool for baryon form factor measurements thanks to its near 4 pi coverage, precise tracking, PID and calorimetry. All hyperons in the SU(3) spin 12 octet and spin 32 decuplet are energetically accessible within the BEPC-II energy range. Recent data on proton and Lambda hyperon form factors will be presented. Furthermore, a world-leading data sample was collected in 2014-2015 for precision measurements of baryon form factors. In particular, the data will enable a measurement of the relative phase between the electric and the magnetic form factors for Lambda and Lambda(+)(c) and hyperons. The modulus of the phase can be extracted from the hyperon polarisation, which in turn is experimentally accessible via the weak, parity violating decay. Furthermore, from the spin correlation between the outgoing hyperon and antihyperon, the sign of the phase can be extracted. This means that the time-like form factors can be completely determined for the first time. The methods will be outlined and the prospects of the BES III form factor measurements will be given. We will also present a planned upgrade

  • Burgi, Matthias
    et al.
    Swiss Fed Res Inst WSL, Res Unit Landscape Dynam, CH-8903 Birmensdorf, Switzerland..
    Bieling, Claudia
    Univ Hohenheim, Societal Transit & Agr 430b, Inst Social Sci Agr, D-70599 Stuttgart, Germany..
    von Hackwitz, Kim
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Archaeology.
    Kizos, Thanasis
    Univ Aegean, Dept Geog, Univ Hill 81100, Mytilene, Greece..
    Lieskovsky, Juraj
    Slovak Acad Sci, Inst Landscape Ecol, Akad 2, Nitra 94910, Slovakia..
    Martin, Maria Garcia
    Univ Freiburg, Nat Conservat & Landscape Ecol, D-79106 Freiburg, Germany..
    McCarthy, Sarah
    Landscape Res Grp Ltd, POB 1482, Oxford OX4 9DN, England..
    Muller, Matthias
    Swiss Fed Res Inst WSL, Res Unit Landscape Dynam, CH-8903 Birmensdorf, Switzerland..
    Palang, Hannes
    Tallinn Univ, Sch Humanities, Ctr Landscape & Culture, EE-10120 Tallinn, Estonia..
    Plieninger, Tobias
    Univ Copenhagen, Dept Geosci & Nat Resource Management, Rolighedsvej 23, DK-1958 Frederiksberg C, Denmark..
    Printsmann, Anu
    Tallinn Univ, Sch Humanities, Ctr Landscape & Culture, EE-10120 Tallinn, Estonia..
    Processes and driving forces in changing cultural landscapes across Europe2017In: Landscape Ecology, ISSN 0921-2973, E-ISSN 1572-9761, Vol. 32, no 11, p. 2097-2112Article in journal (Refereed)
    Abstract [en]

    Context

    Cultural landscapes evolve over time. However, the rate and direction of change might not be in line with societal needs and more information on the forces driving these changes are therefore needed.

    Objectives

    Filling the gap between single case studies and meta-analyses, we present a comparative study of landscape changes and their driving forces based in six regions across Europe conducted using a consistent method.

    Methods

    A LULC analysis based on historical and contemporary maps from the nineteenth and twentieth century was combined with oral history interviews to learn more about perceived landscape changes, and remembered driving forces. Land cover and landscape changes were analysed regarding change, conversions and processes. For all case study areas, narratives on mapped land cover change, perceived landscape changes and driving forces were compiled.

    Results

    Despite a very high diversity in extent, direction and rates of change, a few dominant processes and widespread factors driving the changes could be identified in the six case study areas, i.e. access and infrastructure, political shifts, labor market, technological innovations, and for the more recent period climate change.

    Conclusions

    Grasping peoples’ perception supplements the analyses of mapped land use and land cover changes and allows to address perceived landscape changes. The list of driving forces determined to be most relevant shows clear limits in predictability: Whereas changes triggered by infrastructural developments might be comparatively easy to model, political developments cannot be foreseen but might, nevertheless, leave major marks in the landscape.

  • Chang, Liu
    Stockholm University, Faculty of Science, Department of Physics.
    Ghost in the shell: Studies on subsurface oxygen in oxide-derived copper nanocube catalysts2017Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    With the passage of time and the advancement of our industrial civilization, environmental concerns have become more and more recognized since the 1990s. Carbon dioxide reduction reactions are capable of converting carbon dioxide into valuable hydrocarbons and reducing the carbon emission from the combustion of fossil fuels. This is a promising direction for sustainable energy resources given that the scarcity of fossil fuels is becoming more threatening to the survival of mankind. In recent years, oxide-derived metal nanostructures have been synthesized and show unique catalytic features. Recently, Sloan et al. synthesized a novel oxide-derived copper nanocube structure, which showed a high selectivity toward ethylene over methane and low overpotentials. In this work, the presence of subsurface oxygen in the catalyst surface is tested with density functional theory (DFT) calculations, as a complement to experimental x-ray photoelectron spectroscopy. Due to limitations on the scale of modeling with DFT, the results indicate a very low stability of subsurface oxygen, which give rise to a question if subsurface oxygen would be stable with a reasonably large cluster model. Self-consistent charge density functional tight binding (SCC-DFTB) is adopted to investigate a nanocube model. In this model, a manually reduced cuprious oxide nanocube is constructed and investigated. Subsurface oxygen atoms close to facets are found to be more stable inside. A higher degree of disorder is proposed to be the cause of this difference in stabilizing subsurface oxygen atoms between the slab and nanocube models. The presence of subsurface oxygen enhances the adsorption of CO on the Cu(100) surface, increasing the likelihood for adsorbed CO molecules to dimerize, which is the rate determining step for ethylene production on Cu(100) under low-overpotential conditions. With subsurface electronegative atoms such as oxygen or fluorine, it is also found that the d-band scaling relation could be broken.

  • Public defence: 2018-03-09 10:00 Hamberg, Uppsala
    den Boer, Wendy
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences, Palaeobiology.
    Evolutionary Progression of the Iconic Australasian Kangaroos, Rat-Kangaroos, and their Fossil Relatives (Marsupialia: Macropodiformes)2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The exceptionally diverse macropodiform’s (kangaroos, rat-kangaroos and their fossil allies) currently have a fossil record that spans from the late Oligocene to the Holocene with an Australasian widespread fossil occurence. The origins of the macropodiforms are believed to have been during the Eocene possibly having split from the Phalangeridae. This is largely based on molecular data as there is a complete lack of macropodiform fossil material prior to the late Oligocene leaving the origins of the macropodiforms to be largely speculative. Thus, late Oligocene rat-kangaroo dental fossil elements associated with Palaeopotorous priscus (which shares characteristics observed in both phalangerid and macropodiforms) were examined to get a better insight into the potential origins of the macropodiforms. The results obtained suggested that P. priscus is currently the most basal macropodiform known. Furthermore, due to the absence of adequate macropodiform post-cranial material, the functional eco-morphological interpretation of various macropodiform fossil taxa has been based largely on cranial and dental characteristics. Consequently, the examination of Miocene Balbaridae kangaroo’s (Balbaroo nalima and an untaxonomised balbarid) post-cranial elements was undertaken, suggesting an array of locomotion types (similar to living macropodiforms) and a likely persistent arboreal and quadrupedal lifestyle. In addition, the Pleistocene Protemnodon anak’s post-cranial material are examined, proposing a probable combination of quadrupedal bounding and a slow walking gait alternative to the eminent fast bipedal saltation seen in almost all extant macropodiforms.

  • Walladbegi, Java
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden.
    Gellerstedt, Martin
    Univ West, Trollhättan, Sweden.
    Svanberg, Anncarin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
    Jontell, Mats
    Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden.
    Innovative intraoral cooling device better tolerated and equally effective as ice cooling2017In: Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, E-ISSN 1432-0843, Vol. 80, no 5, p. 965-972Article in journal (Refereed)
    Abstract [en]

    Most of the patients who receive myeloablative therapy prior to stem cell transplantation develop oral mucositis (OM). This adverse reaction manifests as oral mucosal erythema and ulcerations and may require high doses of morphine for pain alleviation. OM may also interfere with food intake and result in weight loss, a need for parenteral nutrition, and impaired quality of life. To date, there have been very few studies of evidence-based interventions for the prevention of OM. Cryotherapy, using ice chips, has been shown to reduce in an efficient manner the severity and extent of OM, although clinical applications are still limited due to several shortcomings, such as adverse tooth sensations, problems with infectious organisms in the water, nausea, and uneven cooling of the oral mucosa. The present proof-of-concept study was conducted to compare the tolerability, temperature reduction, and cooling distribution profiles of an intra-oral cooling device and ice chips in healthy volunteers who did not receive myeloablative treatment, and therefore, did not experience the symptoms of OM. Twenty healthy volunteers used the cooling device and ice chips for a maximum of 60 min each, using a cross-over design. The baseline and final temperatures were measured at eight intra-oral locations using an infra-red thermographic camera. The thermographic images were analysed using two digital software packages. A questionnaire was used to assess the tolerability levels of the two interventions. The intra-oral cooling device was significantly better tolerated than the ice-chips (p = 0.0118). The two interventions were equally effective regarding temperature reduction and cooling distribution. The intra-oral cooling device shows superior tolerability in healthy volunteers. Furthermore, this study shows that temperature reduction and cooling distribution are achieved equally well using either method.

  • Aaboud, M.
    et al.
    Bergeås, Elin Kuutmann
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Bokan, Petar
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gradin, P.O. Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Isacson, Max
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Madsen, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mårtensson, Mikael
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel-Smith, Camilla
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sales De Bruin, Pedro
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    Search for top quark decays t -> qH,with H -> gamma gamma, in root s=13 TeV pp collisions using the ATLAS detector2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 10, article id 129Article in journal (Refereed)
    Abstract [en]

    This article presents a search for flavour-changing neutral currents in the decay of a top quark into an up-type (q = c; u) quark and a Higgs boson, where the Higgs boson decays into two photons. The proton-proton collision data set analysed amounts to 36.1 fb(-1) at root s = 13TeV collected by the ATLAS experiment at the LHC. Top quark pair events are searched for, where one top quark decays into qH and the other decays into bW. Both the hadronic and leptonic decay modes of the W boson are used. No significant excess is observed and an upper limit is set on the t -> cH branching ratio of 2 : 2 x 10(-3) at the 95% confidence level, while the expected limit in the absence of signal is 1 : 6 x 10(-3). The corresponding limit on the tcH coupling is 0.090 at the 95% confidence level. The observed upper limit on the t -> uH branching ratio is 2 : 4 x 10(-3).

  • Public defence: 2018-03-09 13:15 Häggsalen, Uppsala
    Bengtson, Charlotta
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Theoretical Chemistry.
    Quantum Resources for Efficient Excitation Energy Transfer in Natural and Artificial Pigment-Protein Molecular Aggregates2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Recently, long-lasting quantum effects in a number of photosynthetic complexes, which are pigment-protein molecular aggregates (PPMAs), were experimentally verified. These findings created an interest in trying to connect the known highly efficient excitation energy transfer (EET) in these systems to the existence of quantum effects such as quantum coherence and quantum correlations. It also raised the question of how these sensitive quantum effects can survive in such a macroscopic system.

    This thesis explores the existence and possible role of quantum effects in the EET in PPMAs. These systems can be modeled as non-Markovian open quantum systems and quantum effects can be investigated and quantified by methods developed in quantum information theory.

    Firstly, it is found that quantum nonlocal correlations in the EET in the Fenna-Matthews-Olson complex - a PPMA found in nature - are unlikely to exist when the initial excitation occurs in a natural manner. When the initial excitation occurs in an artificial manner by localization of the excitation on one pigment, nonlocal correlations exist on a short time scale. It is further found that in order for nonlocal correlations to be preserved in such a system, the excitation must be trapped on two pigments at the time and these pigments must not interact strongly with other pigments in the complex.

    Secondly, it is shown that quantum coherence is not in general a resource for efficient EET in model systems consisting of a network of pigments; systems optimized with respect to the amount of coherence do not coincide with systems with optimal EET efficiency between two end-site pigments.

    Thirdly, it is found that environmental effects and system-environment interactions can be tuned to optimize the EET efficiency in model PPMAs. The features of optimal environments highly depends on the structure of the pigment system and in particular, the relationship between the pigments excitation energies. It is further shown that a non-Markovian dynamics cannot be connected to an increased EET efficiency in these systems.

  • Abbott, B. P.
    et al.
    CALTECH, LIGO, Pasadena, CA 91125 USA.
    Botner, Olga
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Burgman, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Hallgren, Allan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Pérez de los Heros, Carlos
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Unger, Elisabeth
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Woudt, P. A.
    Univ Cape Town, Dept Astron, Astrophys Cosmol & Grav Ctr, Private Bag X3, ZA-7701 Rondebosch, South Africa.
    Multi-messenger Observations of a Binary Neutron Star Merger2017In: Astrophysical Journal Letters, ISSN 2041-8205, E-ISSN 2041-8213, Vol. 848, no 2, article id L12Article in journal (Refereed)
    Abstract [en]

    On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 . An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ) less than 11 hours after the merger by the One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient's position and days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC 4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta.

  • Public defence: 2018-03-09 10:00 Nbvh 1031, Umeå
    Nordvall, Olov
    Umeå University, Faculty of Social Sciences, Department of Psychology.
    Cognition in interned adolescents: Aspects of executive functions and training2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This doctoral thesis examines adolescents with a history of antisocial behavior with a focus on investigating executive functioning, impulsivity and experiences of everyday executive problems. The thesis further investigates the associations between self-reported and performance-based measures. Finally, it investigates whether processed-based executive function training can influence trained and non-trained executive functions and related scholastic abilities.

    Antisocial behavior is a complex concept, associated with high costs of personal, interpersonal and societal nature. In general, people implement the majority of their life´s share of delinquent and antisocial behaviors around the adolescent years, as described by the so-called age-crime curve. This period is associated with rapid cognitive development, and deficits in this period of time have been associated with an increased susceptibility to partake in antisocial behavior. Also, larger impairments are associated with more severe behaviors. In many western countries, there exist a duality of both welfare and judicial considerations in the case of antisocial individuals who are minors. As compared to adults, persons under the age of criminal responsibility typically face a different combination of rehabilitative and penal consequences from maladaptive, delinquent or antisocial behaviors. In this context, increased understanding of the cognitive underpinnings of antisocial behavior, and how best to support sound cognitive development are therefore relevant to the furthering of rehabilitative practice. This thesis expands on existing knowledge by examining interned adolescents from an executive functions framework and also investigates how it relate to other constructs of clinical relevance.

    This is done in three empirical studies. The first two are cross-sectional and aimed at assessing a number of cognitive constructs and associated behaviors. The third study is aimed at examining the effects of a training intervention on said constructs. The studies indicated poorer pre-test performance by the interned adolescents as compared to their non-interned counterparts. However, no deficits specific to any one executive function was discernable. The results also showed that the internees self-reports expressed more perceived problems with inhibiting behaviors and managing unplanned prompts to shift from a planned activity. They also indicated it harder to resist impulsive behaviors related to negative affect, lower premeditative ability, and had more issues with persevering in prolonged tasks. In addition, there were a few connections between the performance-based and the self-reported accounts of executive functioning. Of particular interest was that the majority of group effects in self-reported constructs was related to the specific executive function updating, a finding not previously reported. This executive function has previously been suggested to be antecedent of antisocial behavior though. As for the training, the only substantial improvement was to perceptual speed, which occurred irrespective of training progression or experimental condition. This was mirrored by the posttest self-reports whose rather modest gains were also unrelated to both experimental conditions and training improvements.

    In conclusion, executive functioning and trait-based cognition are related to some degree, and both associate to antisocial behavior as operationalized by internment status. Process-based cognitive training can however not feasibly be determined to affect or alter these relations.

  • Nilsson, Alexander
    et al.
    Karlstad University.
    Västlund, Filip
    Karlstad University.
    Salomonsson, Sebastian
    Karlstad University.
    Measurements of Connection Speed and Latency2017Report (Other academic)
    Abstract [en]

    This report cover a project done at Karlstad University during the engineering project course DVAE08. The project was aimed to measure response time under load for ”Bredbandskollen”. Functionality was added to measure response time during download and upload. The response time under load was used to be able to explore if excess network queuing occurred in the connection. To be able to measure response time under load over a variety of networks, support wasadded for MONROE,which is an experimental platform for mobile networks. This would enable individual pushing of clients and servers to different Docker containers located around Europe, and subsequently test from them. During upload tests, excessive latency was experienced, so-called bufferbloat.

  • Public defence: 2018-03-09 10:00 F3
    Motamedian, Hamid Reza
    KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.), Solid Mechanics (Div.).
    Beam-to-Beam Contact and Its Application to Micromechanical Simulation of Fiber Networks2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This doctoral thesis covers the topic of modeling the three-dimensional fiber net- works with the finite element method. It contains the part addressing the numerical aspects of the modeling, namely, the contact formulation and application of the developed methods to the fundamental questions such as the effect of randomness in fiber properties and effect of fines and hygroexpansion.

    In the approached used in the work,  the fibers were meshed with beam elements  and the bond between fibers is modeled using point-wise beam-to-beam contact. Contact between beam elements is a specific category of contact problems, which  was introduced by Wriggers and Zavarise in 1997 for normal contact [1] and later extended by Zavarise and Wriggers to include tangential and frictional contact [2]. These formulations encompass a large number of derivations and provide the consistent tangent matrix. We showed, however, the resulting numerical implementations based on these consistent formulations are not sufficiently robust in modeling random fiber networks with a large number of contacts.  In the first papers, we proposed a simpler non-consistent formulation, which turned out to be superior in terms of convergence stability with respect to the load step size for a wide range of loading cases. Having these advantages, it remained equally accurate as the original formulation.  The first paper covered the formulation of normal and tangential contact, and the second paper contains two formulations with both the consistent and non-consistent linearizations for in-plane rotational contact of beams.

    We use the developed formulations to address fundamental problems within the area of fiber networks, which  cannot  be solved  purely  with  experimental  tools.  In  the third article, we investigated the effect of fiber and bond strength variations on the tensile stiffness and strength of fiber networks and concluded that in cases of skewed distribution, using mean values for fiber and bond properties instead of the distributions is not always adequate to assess the changes these properties have on the average mechanical characteristics of the entire network.

    In the fourth paper, the mechanisms behind the improvement of stiffness and strength after PFI refining in the papermaking process is investigated. The PFI refiner is very popular for studying the effect of refining in the lab scale. By using a combination of experimental and numerical tools, we found that density, which is often mentioned as  the main reason behind the improvement of mechanical properties after PFI re- fining, cannot solely explain the degree of the change observed experimentally. We concluded the remaining part of the improvement is caused by the fibrillar fines, in particular, by the fines that cannot be detected with modern automated fiber characterization tools due to the limited resolution of such tools.

    Finally, in the fifth paper, we suggested a multi-scale model to study hygroexpan- sion/shrinkage properties of paper. Due to the anisotropy of the fibers, the stress transfer at the bonded sites has a dominant role in the behavior of paper when exposed to moisture change. While we modeled the bonds between fibers using point-wise contact elements, such stress transfer requires a finite contact area. To solve this limitation and yet preserve the advantages for using beams for modeling fiber networks, we developed a concurrent multi-scale approach.  In this approach,  the bond model is resolved for every bond in the network, and the exchange between the network and bond model is maintained through the current configuration of the fibers being passed to the bond scale,  and the inelastic strains being transferred   back to the network scale. We demonstrated the effectiveness of such approach by comparing it with a full-scale continuum model.  Using this approach, we were able  to complete the existing experimental observation with key insights using the ad- vantage of having unlimited access to the details of the network at each stage of the deformation.

  • Huber, Alexander
    et al.
    Forschungszentrum Julich, Inst Energie & Klimaforsch Plasmaphys, Trilateral Euregio Cluster, D-52425 Julich, Germany..
    Sergienko, Gennady
    Forschungszentrum Julich, Inst Energie & Klimaforsch Plasmaphys, Trilateral Euregio Cluster, D-52425 Julich, Germany..
    Kinna, David
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Huber, Valentina
    Forschungszentrum Julich, Supercomp Ctr, D-52425 Julich, Germany..
    Milocco, Alberto
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England.;Univ Milano Bicocca, Piazza Sci 3, I-20126 Milan, Italy..
    Mercadier, Laurent
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Balboa, Itziar
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Conroy, Sean
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Cramp, Simon
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Kiptily, Vasili
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Kruezi, Uron
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Lambertz, Horst Toni
    Forschungszentrum Julich, Inst Energie & Klimaforsch Plasmaphys, Trilateral Euregio Cluster, D-52425 Julich, Germany..
    Linsmeier, Christian
    Forschungszentrum Julich, Inst Energie & Klimaforsch Plasmaphys, Trilateral Euregio Cluster, D-52425 Julich, Germany..
    Matthews, Guy
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Popovichev, Sergey
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Mertens, Philippe
    Forschungszentrum Julich, Inst Energie & Klimaforsch Plasmaphys, Trilateral Euregio Cluster, D-52425 Julich, Germany..
    Silburn, Scott
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Zastrow, Klaus-Dieter
    Culham Sci Ctr, CCFE, Abingdon OX14 3DB, Oxon, England..
    Response of the imaging cameras to hard radiation during JET operation2017In: Fusion engineering and design, ISSN 0920-3796, E-ISSN 1873-7196, Vol. 123, p. 669-673Article in journal (Refereed)
    Abstract [en]

    The analysis of the radiation damage of imaging systems is based on all different types-of aiialoiue/digital cameras with uncooled as well as actively cooled image sensors in the VIS/NIR/MWIR spectral ranges. The Monte Carlo N-Particle (MCNP) code has been used to determine the neutron fluence at different camera locations in JET. An explicit link between the sensor damage and the neutron fluence has been observed. Sensors show an increased dark-current and increased numbers of hot-pixels. Uncooled cameras must be replaced once per year after exposure to a neutron fluence of similar to 1.9-3.2 x 10(12)neutrons/cm(2). Such levels of fluence will be reached after approximate to 14-22 ELMy H-mode pulses during the future D-T campaign. Furthermore, dynamical noise seen as a random pattern of bright pixels was observed in the presence of hard radiation (neutrons and gammas). Failure of the digital electronics inside the cameras as well as of industrial controllers is observed beyond a neutron fluence of about similar to 4 x 10(9) neutrons/cm(2). The impact of hard radiation on the different types of electronics and possible application of cameras during future D-T campaign is discussed.

  • Gustafsson, Sofia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Lindström, Veronica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Ingelsson, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Hammarlund-Udenaes, Margareta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Syvänen, Stina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology2018In: Neuropharmacology, ISSN 0028-3908, E-ISSN 1873-7064, Vol. 128, p. 482-491Article in journal (Refereed)
    Abstract [en]

    Pathophysiological impairment of the neurovascular unit, including the integrity and dynamics of the blood-brain barrier (BBB), has been denoted both a cause and consequence of neurodegenerative diseases. Pathological impact on BBB drug delivery has also been debated. The aim of the present study was to investigate BBB drug transport, by determining the unbound brain-to-plasma concentration ratio (K-p,K-uu,K-brain), in aged A beta PP-transgenic mice, alpha-synuclein transgenic mice, and wild type mice. Mice were dosed with a cassette of five compounds, including digoxin, levofloxacin (1 mg/kg, s.c.), paliperidone, oxycodone, and diazepam (0.25 mg/kg, s.c.). Brain and blood were collected at 0.5,1, or 3 h after dosage. Drug concentrations were measured using LC-MS/MS. The total brain-to-plasma concentration ratio was calculated and equilibrium dialysis was used to determine the fraction of unbound drug in brain and plasma for all compounds. Together, these three measures were used to determine the Kp,uu,brain value. Despite A beta or alpha-synuclein pathology in the current animal models, no difference was observed in the extent of drug transport across the BBB compared to wild type animals for any of the compounds investigated. Hence, the present study shows that the concept of a leaking barrier within neurodegenerative conditions has to be interpreted with caution when estimating drug transport into the brain. The capability of the highly dynamic BBB to regulate brain drug exposure still seems to be intact despite the presence of pathology. (C) 2017 The Authors. Published by Elsevier Ltd.

  • Polydorou, Konstantina
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    Rocén, Andreas
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics.
    Zabzine, Maxim
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Physics.
    7D supersymmetric Yang-Mills on curved manifolds2017In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, no 12, article id 152Article in journal (Refereed)
    Abstract [en]

    We study 7D maximally supersymmetric Yang-Mills theory on curved manifolds that admit Killing spinors. If the manifold admits at least two Killing spinors (Sasaki-Einstein manifolds) we are able to rewrite the supersymmetric theory in terms of a cohomological complex. In principle this cohomological complex makes sense for any K-contact manifold. For the case of toric Sasaki-Einstein manifolds we derive explicitly the perturbative part of the partition function and speculate about the non-perturbative part. We also briefly discuss the case of 3-Sasaki manifolds and suggest a plausible form for the full non-perturbative answer.

  • Binda, Federico
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Ericsson, Göran
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Conroy, Sean
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Andersson Sundén, Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Calculation of the profile-dependent neutron backscatter matrix for the JET neutron camera system2017In: Fusion engineering and design, ISSN 0920-3796, E-ISSN 1873-7196, Vol. 123, p. 865-868Article in journal (Refereed)
    Abstract [en]

    We investigated the dependence of the backscatter component of the neutron spectrum on the emissivity profile. We did so for the JET neutron camera system, by calculating a profile-dependent backscatter matrix for each of the 19 camera channels using a MCNP model of the JET tokamak. We found that, when using a low minimum energy for the summation of the counts in the neutron pulse height spectrum, the backscatter contribution can depend significantly on the emissivity profile. The maximum variation in the backscatter level was 24% (8.0% when compared to the total emission). This effect needs to be considered when a correction for the backscatter contribution is applied to the measured profile.

  • Finné, Martin
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Archaeology and Ancient History, Classical archaeology and ancient history. Stockholm Univ, Dept Phys Geog, Stockholm, Sweden.;Navarino Environm Observ, Costa Navarino, Messinia, Greece..
    Holmgren, Karin
    Stockholm Univ, Dept Phys Geog, Stockholm, Sweden.;Navarino Environm Observ, Costa Navarino, Messinia, Greece.;Swedish Univ Agr Sci, Uppsala, Sweden..
    Shen, Chuan-Chou
    Natl Taiwan Univ, High Precis Mass Spectrometry & Environm Change L, Dept Geosci, Taipei, Taiwan..
    Hu, Hsun-Ming
    Natl Taiwan Univ, High Precis Mass Spectrometry & Environm Change L, Dept Geosci, Taipei, Taiwan..
    Boyd, Meighan
    Stockholm Univ, Dept Phys Geog, Stockholm, Sweden.;Navarino Environm Observ, Costa Navarino, Messinia, Greece.;Royal Holloway Univ London, Dept Earth Sci, Egham, Surrey, England..
    Stocker, Sharon
    Univ Cincinnati, Dept Class, 410 Blegen Lib, Cincinnati, OH USA..
    Late Bronze Age climate change and the destruction of the Mycenaean Palace of Nestor at Pylos2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 12, article id e0189447Article in journal (Refereed)
    Abstract [en]

    This paper offers new high-resolution oxygen and carbon isotope data from Stalagmite S1 from Mavri Trypa Cave, SW Peloponnese. Our data provide the climate background to the destruction of the nearby Mycenaean Palace of Nestor at Pylos at the transition from Late Helladic (LH) IIIB to LH IIIC, similar to 3150-3130 years before present (before AD 1950, hereafter yrs BP) and the subsequent period. S1 is dated by 24 U-Th dates with an averaged precision of +/- 26 yrs (2s), providing one of the most robust paleoclimate records from the eastern Mediterranean for the end of the Late Bronze Age (LBA). The delta O-18 record shows generally wetter conditions at the time when the Palace of Nestor at Pylos was destroyed, but a brief period of drier conditions around 3200 yrs BP may have disrupted the Mycenaean agricultural system that at the time was likely operating close to its limit. Gradually developing aridity after 3150 yrs BP, i.e. subsequent to the destruction, probably reduced crop yields and helped to erode the basis for the reinstitution of a central authority and the Palace itself.