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  • Hammarberg, Björn
    Stockholm University, Faculty of Humanities, Department of Linguistics, General Linguistics.
    Conditions on transfer in phonology1997In: Second-Language Speech: Structure and Process / [ed] A. James, J. Leather, Berlin & New York: Mouton de Gruyter, 1997, p. 161-180Chapter in book (Other academic)
  • Karlsson, Jonas
    et al.
    Karlstad University, Faculty of Economic Sciences, Communication and IT, Department of Computer Science.
    Di Stasi, Giovanni
    Computer Science Department, University “Federico II” of Naples, Via Claudio 21, 80125 Naples, Italy.
    Kassler, Andreas
    Karlstad University, Faculty of Economic Sciences, Communication and IT, Department of Computer Science.
    Avallone, Stefano
    Computer Science Department, University “Federico II” of Naples, Via Claudio 21, 80125 Naples, Italy.
    An Aggregation Aware Multi-path Forwarding Paradigm for Wireless Mesh Networks2011In: IEEE MASS 2011. Proceedings of the 8th IEEE International Conference on Mobile Ad-hoc and Sensor Systems, IEEE Computer Society, 2011, p. 765-770Conference paper (Refereed)
    Abstract [en]

    In multi-radio wireless mesh networks, a networkdevice simultaneously transmits packets over different channelsby using multiple radios. Such frequency diversity not only increasesthroughput but makes multi-path routing approaches extremelyinteresting. This is because the channel diversity reducesthe risk for intra- and inter-flow interference. A fundamentalproblem to solve is the forwarding strategy which determineswhich packets to be sent over what multi-path segments atany given time. Ideally, the forwarding strategy should scheduleflows according to the capacity constraints imposed by thechannel assignment. However, the possibility to improve MAClayer efficiency by aggregating small packets into larger onesis reduced when packets are forwarded to different next-hops.In this paper, we develop a novel packet forwarding strategyfor multi-radio mesh networks that combines the benefits ofmulti-path routing with packet aggregation. In our cross-layerapproach, we effectively trade-off aggregation opportunities withchannel diversity. Simulation results show that our approach canimprove network throughput and delay by up to 15 percentand 25 percent, respectively, compared with aggregation unawareforwarding strategies.

  • Lönnermark, Anders
    et al.
    RISE - Research Institutes of Sweden, Safety and Transport, Safety.
    Ingason, HaukurRISE - Research Institutes of Sweden, Safety and Transport, Safety.
    Proceedings from the Eighth International Symposium on Tunnel Safety and Security, Borås, Sweden, March 14-16, 20182018Conference proceedings (editor) (Other academic)
    Abstract [en]

    This report includes the Proceedings of the 8th International Symposium on Tunnel Safety and Security (ISTSS) held in Borås, Sweden, 14-16th of March, 2018. The Proceedings include 41 papers given by session speakers and 16 extended abstracts presenting posters exhibited at the Symposium. The papers were presented in 12 different sessions. Among them are Fire Safety Engineering: Cases & Incidents, Fire Safety Engineering: The Aims, Fire Detection, Explosions, Risk Analysis, Fire Safety Engineering: Case studies, Ventilation, Fire Safety Engineering: State of the Art, Fire Dynamics, Fixed Fire Fighting Systems (FFFS) and Evacuation and Human Behavior.

    Each day was opened by invited Keynote Speakers (in total six) addressing broad topics of pressing interest. The Keynote Speakers, selected as leaders in their field, consisted of Hans Brun, the Swedish Defence University, Dr Iain Bowman, Mott MacDonald, Canada, Dr Ying Zhen Li, RISE Research Institutes of Sweden, Dr Johan Lundin, WSP, Sweden, Allan Skovlund, Greater Copenhagen Fire Department, Denmark and Prof David Purser, Hartford Environmental Research, UK. We are grateful that the keynote speakers were able to share their knowledge and expertise with the participants of the symposium.

  • Blanco, Yina Salamanca
    et al.
    Swedish Univ Agr Sci, Dept Mol Sci, POB 7015, SE-75007 Uppsala, Sweden;Univ El Bosque, Environm Engn Program, Carrera 7b Bis 132-11, Bogota, Colombia;Univ El Bosque, Chem Dept, Carrera 7b Bis 132-11, Bogota, Colombia.
    Topel, Onder
    Swedish Univ Agr Sci, Dept Mol Sci, POB 7015, SE-75007 Uppsala, Sweden;Akdeniz Univ, Dept Chem, Fac Sci, TR-07058 Antalya, Turkey.
    Bajnoczi, Eva G.
    Swedish Univ Agr Sci, Dept Mol Sci, POB 7015, SE-75007 Uppsala, Sweden.
    Werner, Josephina
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics. Swedish Univ Agr Sci, Dept Mol Sci, POB 7015, SE-75007 Uppsala, Sweden.
    Björneholm, Olle
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and Condensed Matter Physics.
    Persson, Ingmar
    Swedish Univ Agr Sci, Dept Mol Sci, POB 7015, SE-75007 Uppsala, Sweden.
    Chemical equilibria of aqueous ammonium-carboxylate systems in aqueous bulk, close to and at the water-air interface2019In: Physical Chemistry, Chemical Physics - PCCP, ISSN 1463-9076, E-ISSN 1463-9084, Vol. 21, no 23, p. 12434-12445Article in journal (Refereed)
    Abstract [en]

    Previous studies have shown that the water-air interface and a number of water molecule layers just below it, the surface region, have significantly different physico-chemical properties, such as lower relative permittivity and density, than bulk water. The properties in the surface region of water favor weakly hydrated species as neutral molecules, while ions requiring strong hydration and shielding of their charge are disfavored. In this study the equilibria NH4+(aq) + RCOO-(aq) reversible arrow NH3(aq) + RCOOH(aq) are investigated for R = CnH2n+1, n = 0-8, as open systems, where ammonia and small carboxylic acids in the gas phase above the water surface are removed from the system by a gentle controlled flow of nitrogen to mimic the transport of volatile compounds from water droplets into air. It is shown that this non-equilibrium transport of chemicals can be sufficiently large to cause a change of the chemical content of the aqueous bulk. Furthermore, X-ray photoelectron spectroscopy (XPS) has been used to determine the relative concentration of alkyl carboxylic acids and their conjugated alkyl carboxylates in aqueous surfaces using a micro-jet. These studies confirm that neutral alkyl carboxylic acids are accumulated in the surface region, while charged species, as alkyl carboxylates, are depleted. The XPS studies show also that the hydrophobic alkyl chains are oriented upwards into regions with lower relative permittivity and density, thus perpendicular to the aqueous surface. These combined results show that there are several chemical equilibria between the aqueous bulk and the surface region. The analytical studies show that the release of mainly ammonia is dependent on its concentration in the surface region, as long as the solubility of the carboxylic acid in the surface region is sufficiently high to avoid a precipitation in/on the water-air interface. However, for n-octyl- and n-nonylcarboxylic acid the solubility is sufficiently low to cause precipitation. The combined analytical and surface speciation studies in this work show that the equilibria involving the surface region are fast. The results from this study increase the knowledge about the distribution of chemical species in the surface region at and close to the water-air interface, and the transport of chemicals from water to air in open systems.

  • Strömquist, Lennart
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Physical Geography.
    Geomorfologiska studier av blockhav och blockfält i norra Skandinavien1973Doctoral thesis, monograph (Other academic)
  • Minakshi, Manickam
    et al.
    Murdoch Univ, Engn & Informat Technol, Murdoch, WA 6150, Australia;Helmholtz Inst Ulm Electrochem Energy Storage HIU, D-89081 Ulm, Germany.
    Mitchell, David R. G.
    Univ Wollongong, Australian Inst Innovat Mat, Electron Microscopy Ctr, Innovat Campus, North Wollongong, NSW 2500, Australia.
    Baur, Christian
    Helmholtz Inst Ulm Electrochem Energy Storage HIU, D-89081 Ulm, Germany.
    Chable, Johann
    Helmholtz Inst Ulm Electrochem Energy Storage HIU, D-89081 Ulm, Germany.
    Barlow, Anders J.
    La Trobe Univ, Ctr Mat & Surface Sci, Bundoora, Vic 3086, Australia.
    Fichtner, Maximilian
    Helmholtz Inst Ulm Electrochem Energy Storage HIU, D-89081 Ulm, Germany.
    Banerjee, Amitava
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Chakraborty, Sudip
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
    Ahuja, Rajeev
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. Royal Inst Technol KTH, Dept Mat & Engn, Appl Mat Phys, S-10044 Stockholm, Sweden.
    Phase evolution in calcium molybdate nanoparticles as a function of synthesis temperature and its electrochemical effect on energy storage2019In: NANOSCALE ADVANCES, ISSN 2516-0230, Vol. 1, no 2, p. 565-580Article in journal (Refereed)
    Abstract [en]

    The design of a suitable electrode is an essential and fundamental research challenge in the field of electrochemical energy storage because the electronic structures and morphologies determine the surface redox reactions. Calcium molybdate (CaMoO4) was synthesized by a combustion route at 300 degrees C and 500 degrees C. We describe new findings on the behaviour of CaMoO4 and evaluate the influence of crystallinity on energy storage performance. A wide range of characterization techniques was used to obtain detailed information about the physical and morphological characteristics of CaMoO4. The characterization results enable the phase evolution as a function of the electrode synthesis temperature to be understood. The crystallinity of the materials was found to increase with increasing temperature but with no second phases observed. Molecular dynamics simulation of electronic structures correlated well with the experimental findings. These results show that to enable faster energy storage and release for a given surface area, amorphous CaMoO4 is required, while larger energy storage can be obtained by using crystalline CaMoO4. CaMoO4 has been evaluated as a cathode material in classical lithium-ion batteries recently. However, determining the surface properties in a sodium-ion system experimentally, combined with computational modelling to understand the results has not been reported. The superior electrochemical properties of crystalline CaMoO4 are attributed to its morphology providing enhanced Na+ ion diffusivity and electron transport. However, the presence of carbon in amorphous CaMoO4 resulted in excellent rate capability, suitable for supercapacitor applications.

  • Lundberg, Josefine
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Berglund, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Molin, Daniel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Kinch, Amelie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Intratumoral expression of FoxP3-positive regulatory T-cells in T-cell lymphoma: no correlation with survival2019In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 124, no 2, p. 105-110Article in journal (Refereed)
    Abstract [en]

    Background. In cancer, regulatory T-cells (Tregs) were previously believed to inhibit tumor immunity, leading to reduced survival. However, in hematologic malignancies, including T-cell lymphoma (TCL), a correlation between increased numbers of tumor-infiltrating Tregs and a favorable prognosis has been reported. We aimed to investigate the expression of the Treg biomarker forkhead box protein 3 (FoxP3) in TCL in immunocompetent individuals and explore a possible correlation to overall survival. Methods. In total, 35 diagnostic biopsies of TCL were stained using a FoxP3-specific monoclonal antibody (clone 236A/E7). Visual scoring was performed by counting positive cells in 15 high-power fields. Clinical data were collected retrospectively from medical records. Results. All the TCLs contained FoxP3(+) cells, median 342 FoxP3(+) cells/mm(2) (range 1-3047). The degree of intratumoral expression of FoxP3 varied between the different subtypes of TCL, with the highest frequency found in angioimmunoblastic TCL. The frequency of intratumoral FoxP3(+) cells had no impact on overall survival; neither when using a cutoff value of 200 FoxP3(+) cells/mm(2) (P = 0.84) nor with FoxP3 as a continuous variable (P = 0.63). Conclusions. Intratumoral Tregs are frequently found in TCL in immunocompetent individuals. In this heterogeneous group of TCL, there was no correlation between the density of intratumoral FoxP3(+) cells and overall survival.

  • Gargiulo, Piera
    et al.
    Swiss Grp Clin Canc Res SAKK Coordinating Ctr, Effingerstr 33, CH-3008 Bern, Switzerland.
    Dietrich, Daniel
    Swiss Grp Clin Canc Res SAKK Coordinating Ctr, Effingerstr 33, CH-3008 Bern, Switzerland.
    Herrmann, Richard
    Univ Hosp, Basel, Switzerland.
    Bodoky, Gyorgy
    Szt Laszlo Teaching Hosp, Budapest, Hungary.
    Ruhstaller, Thomas
    Kantonsspital, St Gallen, Switzerland.
    Scheithauer, Werner
    Univ Vienna, Med Sch, Vienna, Austria.
    Glimelius, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Berardi, Simona
    Swiss Grp Clin Canc Res SAKK Coordinating Ctr, Effingerstr 33, CH-3008 Bern, Switzerland.
    Pignata, Sandro
    Fdn G Pascale, Ist Nazl Tumori, Dept Urol & Gynecol, Naples, Italy.
    Brauchli, Peter
    Swiss Grp Clin Canc Res SAKK Coordinating Ctr, Effingerstr 33, CH-3008 Bern, Switzerland.
    Predicting mortality and adverse events in patients with advanced pancreatic cancer treated with palliative gemcitabine-based chemotherapy in a multicentre phase III randomized clinical trial: the APC-SAKK risk scores2019In: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, ISSN 1758-8340, Vol. 11, article id UNSP 1758835918818351Article in journal (Refereed)
    Abstract [en]

    Background: The prognosis of advanced pancreatic cancer (APC) is poor and differs considerably among patients. Therefore, it is clinically relevant to identify patients with APC who are more likely to benefit from palliative chemotherapy with reduced risk of toxicity. To date, there is no prognostic score universally recommended to help clinicians in planning the therapeutic management. Methods: Using individual patient data from 319 cases of APC treated with gemcitabine-based chemotherapy and enrolled in the SAKK 44/00-CECOG/PAN.1.3.001 randomized trial, several baseline variables, including inflammatory markers, were analysed post hoc as predictors of mortality and/or grade 3 or 4 chemotherapy-related toxicity and separate risk scores were developed. Results: Median survival of the study patients was 7.9 months (interquartile range 3.7-13.3 months). Independent predictors of mortality included increased Aspartate transaminase (ASAT), low performance status, increased derived neutrophil to lymphocyte ratio, increased Carbohydrate Antigen 19-9 (CA 19-9), low haemoglobin, presence of pain, presence of metastasis and increased alkaline phosphatase (ALP). During the study, 117 patients experienced at least one grade 3 or 4 adverse event. Independent predictors of toxicity included white blood cells, ALP, renal function and bilirubin levels at baseline. Both models displayed moderate levels of discrimination (C-statistic 0.68 and 0.64 for mortality and toxicity, respectively) and adequate calibration. Conclusions: We developed simple-to-use prognostic scores for mortality and severe toxicity for patients with APC. These scores can be useful in daily practice to identify patients with increased risk of death or toxicity and to plan the most appropriate therapeutic strategy to improve survival and quality of life. Further prospective studies to validate such scores are needed.

  • Urbanaviciute, Indre
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Complex Materials and Devices. Linköping University, Faculty of Science & Engineering.
    Meng, Xiao
    Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands .
    Biler, Michal
    Department of Chemistry – BMC, Uppsala University, Uppsala, Sweden.
    Wei, Yingfen
    Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands .
    Cornelissen, Tim D.
    Linköping University, Department of Physics, Chemistry and Biology, Complex Materials and Devices. Linköping University, Faculty of Science & Engineering.
    Bhattacharjee, Subham
    Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands.
    Linares, Mathieu
    Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics. Linköping University, Faculty of Science & Engineering. Swedish e-Science Research Centre (SeRC), Stockholm, Sweden.
    Kemerink, Martijn
    Linköping University, Department of Physics, Chemistry and Biology, Complex Materials and Devices. Linköping University, Faculty of Science & Engineering.
    Negative piezoelectric effect in an organic supramolecular ferroelectric2019In: Materials Horizons, ISSN 2051-6347, E-ISSN 2051-6355, Vol. 6, p. 1688-1698Article in journal (Refereed)
    Abstract [en]

    The vast majority of ferroelectric materials demonstrate a positive piezoelectric effect. Theoretically, the negative piezoelectric coefficient d33 could be found in certain classes of ferroelectrics, yet in practice, the number of materials showing linear longitudinal contraction with increasing applied field (d33 < 0) is limited to few ferroelectric polymers. Here, we measure a pronounced negative piezoelectric effect in the family of organic ferroelectric small-molecular BTAs (trialkylbenzene-1,3,5-tricarboxamides), which can be tuned by mesogenic tail substitution and structural disorder. While the large- and small-signal strain in highly-ordered thin-film BTA capacitor devices are dominated by intrinsic contributions and originates from piezostriction, rising disorder introduces additional extrinsic factors that boost the large-signal d33 up to −20 pm V’1 in short-tailed molecules. Interestingly, homologues with longer mesogenic tails show a large-signal electromechanical response that is dominated by the quadratic Maxwell strain with significant mechanical softening upon polarization switching, whereas the small-signal strain remains piezostrictive. Molecular dynamics and DFT calculations both predict a positive d33 for defect-free BTA stacks. Hence, the measured negative macroscopic d33 is attributed to the presence of structural defects that enable the dimensional effect to dominate the piezoelectric response of BTA thin films.

  • Hadnagy, Judit (Editor)
    Nordic Council of Ministers, Nordic Welfare Centre.
    Andersson, Bengt (Contributor)
    Nordic Council of Ministers, Nordic Welfare Centre.
    Forsling, Niclas (Contributor)
    Berggren, Sofia H (Contributor)
    Vård och omsorg på distans: 24 praktiska exempel från Norden2019Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    24 praktiska digitala lösningar inom vård och omsorg i våra fem nordiska länder.

    Den här publikationen innehåller de 24 mest betydelsefulla digitala lösningarna inom vård och omsorg i våra fem nordiska länder. Det de har gemensamt är att de är utbredda, det vill säga redan är implementerade på många ställen och fungerar. En annan utmärkande egenskap för de här lösningarna är att de är en samling olika digitala tjänster som gör stor skillnad för många människor runt om i Norden. Alla våra 27 miljoner invånare i Norden kommer på något sätt i kontakt med någon av dessa lösningar någon gång. Antingen berör det dem själva, deras anhöriga eller andra i deras närhet.

    Publikationen riktar sig i första hand till beslutsfattare på olika nivåer men den kan självklart läsas av alla som är intresserade av vilka digitala lösningar som ger effekt inom vård och omsorg.

    Om alla fem länderna i Norden skulle implementera de här välfärdsteknologiska tjänsterna finns det många som tror att vi kan vara på god väg att lösa framtidens utmaningar inom vård och omsorg.

  • Roos, Anna
    et al.
    Swedish Museum of Natural History, Department of Environmental research and monitoring.
    Neimane, Aleksija
    Statens Veterinärmedicinska Anstalt, SVA.
    Harbor porpoise - Health status and causes of death 20182019Report (Other academic)
  • Public defence: 2019-10-21 09:30 F3, Stockholm
    Teng, Penghua
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering.
    CFD MODELLING AND EXPERIMENTS ON AERATOR FLOW IN CHUTE SPILLWAYS2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    A chute spillway is a typical component of large dams for discharging floods. Because of the high water head, the flow velocity in the chute is often in excess of 20 m/s. Consequently, the structure is usually prone to cavitation damages. Flow aeration is evidenced to efficiently eliminate or to mitigate the damages. An aerator is a device that entrains air into the water flows and is an effective technical measure to counter the cavitation damages.

    Aerator flow includes intense air-water exchange and involves a process of air entrainment, transport, and detrainment. Because of the complex phenomena, it is still a challenge to investigate the behaviors of interaction between air and water. It is fundamental to understand the flow behaviors downstream of the aerator. This thesis investigates the aerator flow features using both the Computational Fluid Dynamics (CFD) and advanced measurement techniques.

    The CFD method presents three two-phase flow models to describe the aerator flows, namely, the Volume of Fluid Model, the Mixture Model, and the Two-Fluid Model. They are applied and evaluated via practical engineering projects and experimental data. The Volume of Fluid model leads to reasonable results regarding the water flow discharge and flow fields. For predicting the air concentration distribution and air bubble transport processes, the Two-Fluid Model is superior to others because it includes forces acting on the air bubbles. However, the model still overestimates the air content near the chute bottom. Based on the aerator flow from a chute spillway in Sweden, three two-phase flow models are applied and compared.

    Physical model tests are commonly conducted to investigate aerator flow features. Because of the scale effects, the results may lead to a discrepancy in the flow behaviors compared with the prototype. Thus, CFD modeling becomes an alternative tool when seeking the reason for the difference. Based on the aerator flow in a real spillway, CFD is applied to reproduce the flow; the discrepancy between the model tests and prototype observations is evidenced. The results show similar flow features with the prototype but differ from those of the model tests. An explanation for the discrepancy is discussed in terms of flow features, effect of surface tension in model tests, and the prerequisite for air entrainment of the free-surface flow.

    Laboratory experiments are conducted to study the aerator flow in a chute. Four image-based measurement techniques-i.e., high-speed particle image velocimetry (HSPIV), shadowgraphic image method (SIM), bubble tracking method (BTM), and bubble image velocimetry (BIV)-are employed. The study focuses on issues of exploring characteristic positions of water-air interfaces, interpreting the evaluation process of air bubbles shed from the tip of the air cavity, identifying the probabilistic means for characteristic positions near the fluctuating free surface, and obtaining the flow field both water flow and air bubbles features of the aerator flow. The application of these techniques leads to a better understanding of two-phase flow characteristics of the chute aerator.

  • Roos, Anna
    et al.
    Swedish Museum of Natural History, Department of Environmental research and monitoring.
    Bäcklin, Britt-Marie
    Swedish Museum of Natural History, Department of Environmental research and monitoring.
    Jogsten Ericson, Ingrid
    Örebro University.
    Wang, Thanh
    Örebro University.
    Awad, Raed
    ACES, Stockholm University.
    Benskin, Jonathan
    ACES; Stockholm University.
    POPs, PFAS and metals in ringed seals (Pusa hispida botnica) from the Baltic 1978-20152019Report (Other academic)
  • Olsson, Malin
    et al.
    Luleå tekniska universitet.
    Söderberg, Siv
    Luleå tekniska universitet.
    Meanings of fatigue among women with multiple sclerosis2011Conference paper (Other academic)
  • Olsson, Malin
    Luleå tekniska universitet.
    Expressions of freedom in everyday life: the meaning of women's experiences of living with multiple sclerosis2007Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    The aim of this licentiate thesis was to describe the meaning of women's experiences of living with multiple sclerosis (MS). This licentiate thesis focuses specific on the women's experiences of daily life (I) and the experience of fatigue (II). Narrative interviews were conducted with 10 women living with MS and the interviews were analysed with a phenomenological hermeneutic interpretation. This licentiate thesis proposes that the meaning of living with MS for women can be seen as living an everyday life defined by the body, which imposes living with a restrained freedom in the same time as a feat for freedom in everyday life exists. The constraints of freedom in everyday life, involves the body, relations to others and not being able to involve in everyday life in a desired way. Despite the demanding body which directs the women's life they choose to involve in everyday life instead of withdraw. While the women's experience of freedom is held back the women seam to feat for an own inner freedom, which is used to approach life and meet the demands of illness. The relationship between this inner freedom and the restrained freedom means a feat for freedom in order to meet the conditions that MS brings into the women's everyday life.

  • Olsson, Malin
    Luleå tekniska universitet.
    Meanings of women's experiences of living with multiple sclerosis2010Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The aim of this doctoral thesis was to describe meanings of women's experiences of living with multiple sclerosis (MS). It focuses specifically on the women's experiences of daily life (I), the experience of fatigue (II), experiences of feeling well (III) and experiences of treatment (IV). Narrative interviews were conducted with 25 women living with MS and the interviews were analyzed from a phenomenological hermeneutic interpretation.For women with MS, living with an unrecognizable body meant that the deterioration of their bodies had become clear and served as a hindrance in daily life. The experience of fatigue seemed to mean that the body instead of working as an implement in order to manage daily life had become an enemy. These experiences included bodily changes, which were evident to others, and imposed feelings of being met in a different way. The ill body threatens the women's dignity and they expressed being avoided by others as hurtful. Despite the fact of all aspects of daily life are being affected by illness, the women with MS nevertheless do find ways to experience feeling well. Feeling well, for women with MS can be understood as finding a pace where daily life goes on and the illness is not the dominant experience.This thesis suggests that meanings of women's experiences of living with MS can be comprehended as a movement between the two dimensions of having a value and feeling unimportant to others. In the dimension of having a value, feeling well is brought forward, meanwhile the dimension of feeling unimportant to others, implies suffering in the daily lives of women with MS. For these women recognizing oneself as valuable and sharing an understanding are important in order to feel dignified in daily life and to experience feeling well.

  • Public defence: 2019-10-14 10:15 Room 2002, Uppsala
    Pöder Balkeståhl, Sebastian
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Mathematics.
    Simple homotopy type of the Hamiltonian Floer complex2019Licentiate thesis, monograph (Other academic)
    Abstract [en]

    For an aspherical symplectic manifold M, closed or with convex contact boundary, and with vanishing first Chern class, a Floer chain complex is defined for Hamiltonians linear at infinity with coefficients in the group ring of the fundamental group of M. For two non-degenerate Hamiltonians of the same slope continuation maps are shown to be simple homotopy equivalences. As a corollary the number of contractible Hamiltonian orbits of period 1 can be bounded from below.

  • Eriksson, Jenny
    et al.
    Swedish National Road and Transport Research Institute, Infrastructure, Infrastructure maintenance. VTI.
    Forsman, Åsa
    Swedish National Road and Transport Research Institute, Traffic and road users, Traffic Safety and Traffic System.
    Niska, Anna
    Swedish National Road and Transport Research Institute, Infrastructure, Infrastructure maintenance.
    Karlström, Jones
    Swedish National Road and Transport Research Institute, Infrastructure, Infrastructure maintenance.
    Enhetlig metod för cykelflödesmätningar: en förberedande studie2019Report (Other academic)
    Abstract [en]

    There is an objective of increasing cycling nationally, regionally and in many Swedish municipalities. The extent of cycling can be followed up with either travel surveys (TSs) or by measuring the bicycle flow. The Traffic Analysis Authority was commissioned by the Government to develop and propose a uniform method for systematic measurements of bicycle traffic at a local and regional level and their report was published in January 2018. Bicycle traffic can be measured in different ways and the two most common methods are (1) measurements by counting bicycles (manually or with detecting equipment) in the street area or (2) travel surveys (TSs). In this report, we focus only on counting cyclists in the street area. Today, the methods of counting bicyclists are limited, and they do not enable estimations of kilometers travelled by bicycle per average day in a municipality.

    In order to achieve a broad application, it is necessary to investigate the possible obstacles that exist to use the Traffic Analysis's proposal for a uniform method, and this will be done in the following steps, where step 1 is described in this report:

    1. A preparatory study: Suggest a set-up of a pilot study

    2. Conduct a pilot study to establish a uniform and systematic approach, and finally

    3. Determine the final uniform and systematic method.

    The purpose of the preparatory study presented in this report is to adapt the Traffic Analysis's proposal to a uniform method for estimating the kilometers travelled by bicycle per average day, based on municipal conditions. The preparatory study will also lead to a proposal for a pilot study in which the adapted method is tested, and issues related to delimitations and definitions can be decided. The pilot study will be carried out in a follow-up project with a number of municipalities. This will result in a final determination of a uniform method for estimating the kilometers travelled by bicycle per average day.

  • ATK årsrapport 20182019Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    Automatisk trafiksäkerhetskontroll (ATK) är ett system för automatisk hastighetsövervakning med kameror. Målet med trafiksäkerhetskameror är att sänka medelhastigheten på våra mest olycksdrabbade vägar och att på det sättet få ner antalet döda och allvarligt skadade. Systemet förvaltas av Trafikverket och Polisen.

  • Public defence: 2019-10-10 10:00 F11
    Berglund, Daniel
    KTH, School of Engineering Sciences (SCI), Mathematics (Dept.), Mathematical Statistics.
    Models for Additive and Sufficient Cause Interaction2019Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    The aim of this thesis is to develop and explore models in, and related to, the sufficient cause framework, and additive interaction. Additive interaction is closely connected with public health interventions and can be used to make inferences about the sufficient causes in order to find the mechanisms behind an outcome, for instance a disease.

    In paper A we extend the additive interaction, and interventions, to include continuous exposures. We show that there does not exist a model that does not lead to inconsistent conclusions about the interaction.

    The sufficient cause framework can also be expressed using Boolean functions, which is expanded upon in paper B. In this paper we define a new model based on the multifactor potential outcome model (MFPO) and independence of causal influence models (ICI).

    In paper C we discuss the modeling and estimation of additive interaction in relation to if the exposures are harmful or protective conditioned on some other exposure. If there is uncertainty about the effects direction there can be errors in the testing of the interaction effect.

  • Dobler, G.
    et al.
    Bestehorn, M.
    Antwerpen, M.
    Överby, Anna K.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
    Complete Genome Sequence of a Low-Virulence Tick-Borne Encephalitis Virus Strain2016In: Microbiology Resource Announcements, ISSN 2576-098X, Vol. 4, no 5, article id e01145-16Article in journal (Refereed)
    Abstract [en]

    We report here the complete genome sequence (GenBank accession no. KX268728) of tick-borne encephalitis strain HB171/11, isolated from an Ixodes ricinus tick from a natural focus where human neurological disease is rare. The strain shows unique characteristics in neuroinvasiveness and neurovirulence.

  • Andersson, Catarina
    Umeå University, Faculty of Science and Technology, Department of Science and Mathematics Education.
    Formative assessment: and the component of adjusted teacher instruction2017In: Proceeding of the Tenth Congress of the European Society for Research in Mathematics Education (CERME10) / [ed] Dooley, T Gueudet, G, Dublin: DCU Institute of Education and ERME , 2017, p. 3419-3426Conference paper (Refereed)
    Abstract [en]

    This theoretical paper is based on an empirical study where the framework of formative assessment by Wiliam and Thompson was used to analyze teachers' use of formative assessment in their mathematics classroom practice. The paper argues for treating a component named Adjusted Teacher Instruction (ATI) as a key strategy in complement to the five key strategies in the original framework. ATI is a significant component in formative assessment, but also particularly challenging for teachers to implement in their classroom practice. Treating ATI as a key strategy could facilitate the analysis of teachers' use of formative assessment activities and enhance the understandings about what kind of ATIs are most useful for whom under what conditions. Extended understandings about effective formative assessment activities are important in decisions about what formative assessment to include in teacher education and in-service training for teachers.

  • Milne, Richard
    et al.
    Morley, Katherine I
    Howard, Heidi Carmen
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics.
    Niemiec, Emilia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics.
    Nicol, Dianne
    Critchley, Christine
    Prainsack, Barbara
    Vears, Danya
    Smith, James
    Steed, Claire
    Bevan, Paul
    Atutornu, Jerome
    Farley, Lauren
    Goodhand, Peter
    Thorogood, Adrian
    Kleiderman, Erika
    Middleton, Anna
    Trust in genomic data sharing among members of the general public in the UK, USA, Canada and Australia2019In: Human Genetics, ISSN 0340-6717, E-ISSN 1432-1203Article in journal (Refereed)
    Abstract [en]

    Trust may be important in shaping public attitudes to genetics and intentions to participate in genomics research and big data initiatives. As such, we examined trust in data sharing among the general public. A cross-sectional online survey collected responses from representative publics in the USA, Canada, UK and Australia (n = 8967). Participants were most likely to trust their medical doctor and less likely to trust other entities named. Company researchers were least likely to be trusted. Low, Variable and High Trust classes were defined using latent class analysis. Members of the High Trust class were more likely to be under 50 years, male, with children, hold religious beliefs, have personal experience of genetics and be from the USA. They were most likely to be willing to donate their genomic and health data for clinical and research uses. The Low Trust class were less reassured than other respondents by laws preventing exploitation of donated information. Variation in trust, its relation to areas of concern about the use of genomic data and potential of legislation are considered. These findings have relevance for efforts to expand genomic medicine and data sharing beyond those with personal experience of genetics or research participants.

  • Svensson, Daniel
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden; Division of CBRN Security and Defence, FOI–Swedish Defence Research Agency, Umeå, Sweden.
    Öhrman, Caroline
    Division of CBRN Security and Defence, FOI–Swedish Defence Research Agency, Umeå, Sweden.
    Bäckman, Stina
    Division of CBRN Security and Defence, FOI–Swedish Defence Research Agency, Umeå, Sweden.
    Karlsson, Edvin
    Division of CBRN Security and Defence, FOI–Swedish Defence Research Agency, Umeå, Sweden.
    Nilsson, Elin
    Division of CBRN Security and Defence, FOI–Swedish Defence Research Agency, Umeå, Sweden.
    Byström, Mona
    Division of CBRN Security and Defence, FOI–Swedish Defence Research Agency, Umeå, Sweden.
    Lärkeryd, Adrian
    Division of CBRN Security and Defence, FOI–Swedish Defence Research Agency, Umeå, Sweden.
    Myrtennäs, Kerstin
    Division of CBRN Security and Defence, FOI–Swedish Defence Research Agency, Umeå, Sweden.
    Stenberg, Per
    Division of CBRN Security and Defence, FOI–Swedish Defence Research Agency, Umeå, Sweden.
    Qu, Ping-hua
    Trygg, Johan
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden.
    Scholz, Holger C.
    Forsman, Mats
    Division of CBRN Security and Defence, FOI–Swedish Defence Research Agency, Umeå, Sweden.
    Sjödin, Andreas
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden; Division of CBRN Security and Defence, FOI–Swedish Defence Research Agency, Umeå, Sweden.
    Complete Genome Sequence of Francisella guangzhouensis Strain 08HL01032(T), Isolated from Air-Conditioning Systems in China2015In: Microbiology Resource Announcements, ISSN 2576-098X, Vol. 3, no 2, article id e00024-15Article in journal (Refereed)
    Abstract [en]

    We present the complete genome sequence of Francisella guangzhouensis strain 08HL01032(T), which consists of one chromosome (1,658,482 bp) and one plasmid ( 3,045 bp) with G+C contents of 32.0% and 28.7%, respectively.

  • Public defence: 2019-10-17 10:00 FB42, Stockholm
    Pernow, Marcus
    KTH, School of Engineering Sciences (SCI), Physics, Particle and Astroparticle Physics.
    Phenomenology of SO(10) Grand Unified Theories2019Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    Although the Standard Model (SM) of particle physics describes observations well, there are several shortcomings of it. The most crucial of these are that the SM cannot explain the origin of neutrino masses and the existence of dark matter. Furthermore, there are several aspects of it that are seemingly ad hoc, such as the choice of gauge group and the cancellation of gauge anomalies.

    These shortcomings point to a theory beyond the SM. Although there are many proposed models for physics beyond the SM, in this thesis, we focus on grand unified theories based on the SO(10) gauge group. It predicts that the three gauge groups in the SM unify at a higher energy into one, which contains the SM as a subgroup. We focus on the Yukawa sector of these models and investigate the extent to which the observables such as fermion masses and mixing parameters can be accommodated into different models based on the SO(10) gauge group. Neutrino masses and leptonic mixing parameters are particularly interesting, since SO(10) models naturally embed the seesaw mechanism.

    The difference in energy scale between the electroweak scale and the scale of unification spans around 14 orders of magnitude. Therefore, one must relate the parameters of the SO(10) model to those of the SM through renormalization group equations. We investigate this for several different models by performing fits of SO(10) models to fermion masses and mixing parameters, taking into account thresholds at which heavy right-handed neutrinos are integrated out of the theory. Although the results are in general dependent on the particular model under consideration, there are some general results that appear to hold true. The observ- ables of the Yukawa sector can in general be accommodated into SO(10) models only if the neutrino masses are normally ordered and that inverted ordering is strongly disfavored. We find that the observable that provides the most tension in the fits is the leptonic mixing angle θ2l3, whose value is consistently favored to be lower in the fits than the actual value. Furthermore, we find that numerical fits to the data favor type-I seesaw over type-II seesaw for the generation of neutrino masses.

  • Andersson, Britt-Inger
    Förstudie Del B Underlag till en FoU-strategi: inspel till myndighetens strategiska plan 2021-20232019Report (Other academic)
    Abstract [sv]

    Detta är en förstudie som handlar om myndighetens verksamhet inom forskning och utveckling (FoU). Syftet med studien är att ta fram ett underlag till en FoU-strategi med inspel till myndighetens kommande strategiska plan. Se del A av rapporten för en sammanfattning av arbetet.

  • Public defence: 2019-10-11 09:00 Rudbecksalen, Uppsala
    La Fleur, Linnéa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Mutation and immune profiling of non-small cell lung cancer2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Several novel therapies that target molecular alterations and immune checkpoints in lung cancer have been introduced in the last decade. Still, only a minority of patients obtain long term disease control and overall survival remains poor. The aim of this thesis was to characterize the landscape of genetic alterations and immune cell infiltrates in tumor tissues from a large representative patient cohort of non-small cell lung cancer (NSCLC).

    The mutational status of 82 genes related to lung cancer development were evaluated, in paper I, by a targeted re-sequencing approach adapted to work on “real-life” samples of mixed quality. We observed a remarkably high prevalence of activating KRAS mutations. Otherwise, the mutation spectrum resembled other western lung cancer populations. Poor survival was linked to subgroups of lung adenocarcinoma with mutations in TP53, STK11 and SMARCA4, independent of concomitant KRAS mutations. In lung squamous cell carcinoma, patients with mutations in CSMD3 had better survival.

    The infiltration of tumor-associated immune cells was assessed by immunohistochemical analysis in paper II. Previously described immune response patterns termed “inflamed” and “desert” were confirmed in our dataset. In addition, we discovered a new immune phenotype characterized by overall sparse presence of most immune cell types except for a distinct infiltration of NK and plasma cells. This novel immune class displayed a favorable prognosis and was therefore designated “oasis”.

    In paper III, infiltration of macrophage subtypes was evaluated by immunohistochemical analysis of CD68, CD163, MSR1 and MARCO. The majority of macrophages exhibited a tumor promoting phenotype and expression of MARCO, a targetable scavenger receptor, was detected in a distinct subset of NSCLC patients. Further investigation of the functional roles of MARCO in a human NSCLC setting was carried out in paper IV. Here, MARCO expression on cultured myeloid cells could be induced by NSCLC cell lines. The MARCO+ cells displayed an immunosuppressive phenotype and could effectively suppress the cytolytic effect of NK cells and CD8+ T cells. A monoclonal antibody targeting MARCO removed these inhibitory effects of the MARCO+ cells.

    In summary, this thesis contributes knowledge on the genetic and immunologic underpinning of lung cancer that forms the basis for current and future treatment strategies in the evolving era of personalized oncology and pathology.

  • Nilsson, Magnus
    Linköpings universitet, Institutionen för samhälls- och välfärdsstudier.
    Det blev inte av : äldre ensamstående män utan barn på landsbygden: rapport nr 3 från forskningsprojektet Boende, åldrande, livslopp på landsbygden2011Book (Other academic)
    Abstract [sv]

    Sverige har det gjorts få studier av vad det innebär att åldras på landsbygden. Den övervägande majoriteten av forskningen om äldre människor och deras livsvillkor produceras med empiriskt material, såväl som frågeställningar, som tar sin utgångspunkt i de förutsättningar som det urbana livet ger. Det urbana fungerar normerande och livet på landsbygden uppfattas ofta i termer av vad som saknas där i förhållande till livet i staden. Kunskapsutvecklingen om livet i glesbygd har därmed kommit att hamna i skymundan (SOU 2006:106). Denna studie är ett bidrag till forskningen om att åldras på landsbygden och i fokus är livet och livsvillkoren för äldre ensamstående män utan barn utifrån ett genusperspektiv. För studien har elva ensamstående barnlösa män på landsbygden intervjuats.

  • Public defence: 2019-10-11 13:15 Rosénsalen, entrance 95/96, NBV, Uppsala
    Kassa, Ann-Marie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Pediatric Surgery.
    Living with VACTERL association: From the perspectives of children, adolescents and their parents2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    VACTERL association is a rare and complex congenital condition often requiring repeated surgery and entailing various physical sequelae. Knowledge is scarce regarding experiences of the health condition and health care, need of support at school, health-related quality of life (HRQoL), and psychological well-being in children, adolescents and their parents.

    This thesis aims to investigate various aspects of living with VACTERL association, from the perspectives of children, adolescents and their parents.

    Ten children aged five to eight years were interviewed using the computer-assisted interview technique In My Shoes (Study I). They expressed awareness of their health history and felt proud but also different due to physical dysfunction. While happy to meet familiar staff in the hospital they voiced worries about medical procedures.

    The nineteen parents interviewed described crisis reactions on the discovery of malformations in their child (Study II). Parental involvement in care was reported from the initial hospital admission until taking responsibility for treatments at home. Eventually the health condition became integrated in everyday life. Insufficient emotional and limited medical support were reported. Various levels of professionalism among healthcare professionals and discrepancies concerning knowledge and experience between the tertiary and local hospitals were described.

    In ten evaluated pre-school children (Study III), intelligence measured by Wechsler-scales was within the normal range. Eight children had attention difficulties and two were later diagnosed with attention deficit hyperactivity disorder (ADHD). All children had physical dysfunctions affecting their nutrition, bowel or bladder functions. All needed extra support and adjustments at school.

    Forty children and adolescents responded to validated questionnaires of DISABKIDS and Beck inventories (Study IV). The HRQoL was comparable to European children with chronic conditions. Their psychological well-being was similar to that of Swedish school children and significantly better than that of a clinical sample. Self-reported anxiety and depression in 38 mothers and 33 fathers were comparable to non-clinical samples.

    In conclusion, regular follow-up by multi-professional team with continuity is crucial to optimise the physical function in children with VACTERL, to identify those in need of extra support at school and to detect reduced psychological well-being in children and parents. Fear of medical procedures may be reduced by carefully providing information and individual care strategies. For the parents psychological processing, support from medical experts and peers is essential to achieve self-confidence and adaptation. Transfer of knowledge and information between multi-professional teams at the local and tertiary hospitals could be improved by the use of video sessions.

  • Jeppsson, Fredrik
    et al.
    Linköpings universitet.
    Haglund, Jesper
    Karlstad University, Faculty of Health, Science and Technology (starting 2013), Department of Engineering and Physics (from 2013). SMEER.
    Sampublicering med studenter – ett sätt att stärka forskningsanknytningen i lärarutbildningen2019In: Högre Utbildning, ISSN 2000-7558, E-ISSN 2000-7558, Vol. 9, no 1, p. 98-111Article in journal (Refereed)
    Abstract [sv]

    Lärarutbildningen uppmärksammas inte sällan för att dess studenter har svårt att uppnå den nivå av akademiskt skrivande som krävs, inte minst vid examensarbeten. Som kontrast till den beskrivningen vill vi lyfta fram motexempel, där lärarstudenters examensarbeten och andra skrivuppgifter har nått en sådan kvalitet att de genom samförfattande med handledare och andra medförfattare har kunnat omarbetas och publiceras som vetenskapliga artiklar eller i mer lärartillvända forum, i vårt fall inom fysikdidaktik. Samförfattande med lärarstudenter kan på så vis vara ett sätt att stärka forskningsförankringen i lärarutbildningen. Förutsättningarna för att kunna lyckas med detta diskuteras, bland annat utifrån att under lärarutbildningen gradvis låta studenterna inlemmas i en praktikgemenskap av ämnesdidaktisk forskning.

  • Andersson, Britt-Inger
    Förstudie Del A Underlag till en FoU-strategi 2023: inspel till myndighetens strategiska plan 2021-20232019Report (Other academic)
    Abstract [sv]

    Syftet med förstudien är att ta fram ett underlag till en FoU-strategi för myndigheten. Den ska användas som inspel till myndighetens kommande strategiska plan 2021– 2023. Myndigheten saknar en FoU-strategi som omfattar hela verksamheten. Idag utförs en liten del egen forskningsverksamhet främst runforskning och en större del annan FoU-verksamhet. I stort sett all FoU utförs i samarbete och/eller samverkan med externa parter exempelvis museer, universitet och högskolor. I rapporten har sex kategorier av FoU-verksamhet identifierats. De flesta avdelningar utför FoU-verksamhet främst Kulturvårdsavdelningen, men även Arkiv och bibliotek samt Informationsavdelningen. Kulturmiljöavdelningen arbetar främst operativt med FoU-anslaget och det tillhörande externa FoU-programmet. Staben arbetar strategiskt med FoU-frågor i Sverige och inom EU samt ansvarar strategiskt för det externa FoU-programmet.

  • Public defence: 2019-10-11 13:15 Geijersalen, Uppsala
    Bergman, Karl
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Philosophy, Logic and Metaphysics.
    Communities of Judgment: Towards a Teleosemantic Theory of Moral Thought and Discourse2019Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This thesis offers a teleosemantic account of moral discourse and judgment. It develops a number of views about the function and content of moral judgments and the nature of moral discourse based on Ruth Millikan’s theory of intentional content and the functions of intentional attitudes.

    Non-cognitivists in meta-ethics have argued that moral judgments are more akin to desires and other motivational attitudes than to descriptive beliefs. I argue that teleosemantics allows us to assign descriptive content to motivational attitudes and hence that even if the non-cognitivist is correct, moral judgments can be said to describe the world. Moreover, given further teleosemantic assumptions, this conclusion has consequences that are both surprising and interesting. First of all, while moral judgments have descriptive content, moral statements do not. The purpose of moral discourse is not to convey beliefs that are true simpliciter, but to convey attitudes that are descriptively correct when tokened by the addressee. Consequently, moral discourse requires speakers to adapt to hearers in order to secure their assent and bring them into "community of judgment" with themselves.

    Secondly, the descriptive content of a motivational attitude is partly a matter of the subject’s own preferences and circumstances. In particular, the descriptive correctness of a moral judgment is partly a function of the degree to which it is shared with others. Since a moral judgment also motivates the subject to spread it, it has the ability to, in a certain sense, make itself true. If regular descriptive beliefs are supposed to adapt the subject to the world, a moral judgment also has the capacity to adapt the world to the subject.

  • Jungsberg, Leneisja
    et al.
    Nordic Council of Ministers, Nordregio.
    Turunen, Eeva
    Nordic Council of Ministers, Nordregio.
    Heleniak, Timothy
    Nordic Council of Ministers, Nordregio.
    Wang, Shinan
    Nordic Council of Ministers, Nordregio.
    Ramage, Justine
    Nordic Council of Ministers, Nordregio.
    Roto, Johanna
    Nordic Council of Ministers, Nordregio.
    Atlas of population, society and economy in the Arctic2019Report (Other academic)
    Abstract [en]

    The objective of the Atlas of Population, Society and Economy in the Arctic is to provide an in-depth overview of the changes that are affecting populations in the circumpolar North. Continuous environmental, economic and social changes are currently underway in the Arctic regions. Global warming, for example, is challenging traditional livelihoods, accessibility and economic activities. The atlas presents a collection of standardised indicators that illustrate the state of the Arctic regions focusing on demography, society, economy, production, accessibility and infrastructure as well as physical conditions and resources in the Arctic. As part of Nunataryuk’s research, this working paper examines the environmental challenges related to permafrost by combining geographical data with demographic data in order to describe coastal and inland settlements. Permafrost thaw is a challenge for many Arctic communities, as it has an impact on infrastructure, economy and the health of Arctic populations.

  • Kuttah, Dina K
    Swedish National Road and Transport Research Institute, Infrastructure, Pavement Technology.
    An overview on portable roads and airfields: using of matting systems as temporary and semi-permanent roads and airfields2019Report (Other academic)
    Abstract [en]

    Matting systems used as roadways and airfields are new innovative techniques used to solve mobility problems and make it easier to get around and transport goods under different climate and traffic conditions. The portable roads are extremely versatile and can be used for servicing areas with poor ground conditions, heavy load requirements and high traffic density. They could be used to facilitate vehicular access into areas that contain saturated soils, wetlands or soft/poor subgrade conditions and make secluded areas accessible (remote regions in general.).

    Moreover, portable roads can be used as temporary roads for emergency situations to enable aid deliveries to disaster areas, or during maintenance of existing roads or as temporary roads during a traffic jam.

    Regarding the portable airfields, some portable runways have been developed to support the heavy rolling loads, including heavy unmanned aircrafts and heavy maintenance equipment. Most of the available portable airfields are used in remote areas where existing runway or airport infrastructure is limited or non-existent. The use of mats to construct an airfield depends on many factors, such as ground conditions, the type and weight of aircraft being deployed, the expected usage levels, and the time available to construct the airfield.

    The objective of this report is to provide a practical perspective on construction and performance characteristics of some available portable roads and airfields systems that can be used to solve temporary and semi-permanent transport problems. Literature results are presented to educate the readers on available systems’ types and the best uses of each system in different applications.

  • Public defence: 2019-10-25 13:00 M102, Sundsvall
    Khisro, Jwan
    Mid Sweden University, Faculty of Science, Technology and Media, Department of Information Systems and Technology.
    Transformation of business collaboration in a digital age: Towards a multi-relation perspective2019Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    The process of digitalisation is progressively transforming the way business is carried out and how enterprises collaborate. In this digital age, characterised by collaborations among a larger community of suppliers, customers, employees, and governments, all partners need to understand avariety of relations and how digitalisation transforms them. However, it is difficult to understand the multitude of unclear or even unknown relations generated by re-coordinating different types of relations in this digital age. Accordingly, this thesis contributes to the understanding of the transformation of business collaboration by exploring how collaboration can be understood in a digital age. The theoretical concepts involved collaboration, enterprise architecture, enterprise interoperability, and boundary object. These concepts enabled digging deeper into the complexity of sharing and aligning social and cultural worlds between communities of practice. The methodology employed was hermeneutics, which was suitable for understanding human activities. The study object concerned national development of data hubs for the electricity market in Denmark and Sweden, which replaced an old way of communicating point to point between companies. This was implemented in order to coordinate and manage data transactions between grid companies and electricity suppliers. The results indicated that digitalisation tends to increase the ability to manage collaboration and even closer relations among partners by clearly identifying every partner role and responsibility. Further, business collaboration appeared to transform from a traditional collaboration to a multi-relation collaboration that addressed digital age demands more comprehensively.

  • Pilerot, Ola
    University of Borås, Faculty of Librarianship, Information, Education and IT.
    Nyanlända biblioteksguider: En studie av nyanlända medarbetare på folkbibliotek2019Report (Other academic)
  • Jordahl, Henrik
    Institutet för Näringslivsforskning (IFN), stockholm, Sweden.
    En effektivare skola ger mer kunskap2016Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    Den svenska skolan behöver ett effektivt kvalitetsarbete. Pisa-resultaten talar sitt tydliga språk, och det är högst angeläget att vidta åtgärder som kan förbättra skolresultaten. Rapporten fokuserar på skolors systematiska kvalitetsarbete och effektiviseringsarbete och hur dessa påverkar elevernas prestationer.

  • Bergman, Mats A.
    et al.
    Södertörns högskola, Huddinge, Sveirge.
    Jordahl, Henrik
    Institutet för Näringslivsforskning (IFN), Sverige.
    Goda år på ålderns höst?: En ESO-rapport om konkurrens i äldreomsorgen2014Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    Under de senaste decennierna har det blivit möjligt att driva äldreomsorg i privat regi. Förespråkarna för denna utveckling pekar på valfrihet och ökad effektivitet. Kritikerna talar om vanvård och menar att äldreomsorg inte lämpar sig för marknadslösningar. I rapporten analyserar forskarna förutsättningarna för att nå god kvalitet och effektivt resursutnyttjande vid marknadsliknande lösningar i äldreomsorgen. De frågor som diskuteras i rapporten är bl.a.:

    • Hur fungerar den svenska äldreomsorgsmarknaden?
    • Under vilka förutsättningar kan valfrihet och konkurrens förbättra omsorgen?
    • Vilka krav kan och bör ställas på äldreomsorgens utförare?
    • Vilken betydelse har brukarval för omsorgens kvalitet?
  • Jordahl, Henrik
    et al.
    Research Institute of Industrial Economics (IFN), Stockholm, Sweden.
    Persson, Lovisa
    Research Institute of Industrial Economics (IFN), Stockholm, Sweden.
    Exploring Digital Time Measurement in the Public Sector: Labor Productivity and Service Quality in Home Care2018Report (Other academic)
    Abstract [en]

    We measure labor productivity in home care using new data from the recent introduction of digital time measurement in Swedish municipalities. By measuring worker utilization (delivered hours as a share of worked hours) we avoid several problems that have plagued previous studies of public sector productivity. The time use measure exposes substantial variation in productivity between home care units, suggesting room for improvement. More productive units deliver a larger share of the hours approved by care managers and have equally satisfied users.

  • Berggren, Niclas
    et al.
    Research Institute of Industrial Economics (IFN), Stockholm, Sweden; Department of Institutional, Experimental and Environmental Economics (KIE), University of Economics in Prague, Prague, the Czech Republic.
    Jordahl, Henrik
    Research Institute of Industrial Economics (IFN), Stockholm, Sweden; IZA, Bonn, Germany.
    Poutvaara, Panu
    University of Munich, Munich, Germany; Ifo Institute, Germany; CESifo, Munich, Germany; CReAM, London, UK; IZA, BOnn, Germany.
    The Right Look: Conservative Politicians Look Better and Voters Reward It2015Report (Other (popular science, discussion, etc.))
    Abstract [en]

    Since good-looking politicians win more votes, a beauty advantage for politicians on the left or on the right is bound to have political consequences. We show that politicians on the right look more beautiful in Europe, the United States and Australia. Our explanation is that beautiful people earn more, which makes them less inclined to support redistribution. Accordingly, our model predicts that voters use beauty as a cue for conservatism when they do not know much about candidates and that politicians on the right benefit more from beauty in low-information elections. Evidence from real and experimental elections confirms both predictions.

  • Andersson, Fredrik
    et al.
    Lund University, Lund, Sweden; IFN, Stockholm, Sweden.
    Jordahl, Henrik
    Örebro University, Örebro University School of Business. IFN, Stockholm, Sweden; Cesifo, Munich, Germany; IZA, Bonn, Germany.
    Josephson, Jens
    IFN, Stockholm, Sweden; Stockholm Business School, Stockholm University, Stockholm, Sweden.
    Outsourcing Public Services: Contractibility, Cost, and Quality2019Report (Other academic)
    Abstract [en]

    We review the literature on public sector outsourcing to explore if the theoretical predictions from the incomplete contracts literature hold up to recent empirical evidence. Guided by theory, we arrange services according to the type and magnitude of their contractibility problems. The empirical studies point at rather favourable outsourcing outcomes, in terms of costs and quality, for services without severe contracting problems. The picture is more mixed for services with tougher contracting problems, with the weight of the evidence in favour of public provision. This difference between services is largely in line with the property-rights framework and theories of incomplete contracts.

  • Westum, Asbjörg
    Umeå University, Sweden.
    Ris, skäver och skärva: Folklig kategorisering av några barnsjukdomar ur ett kognitivt semantiskt perspektiv1999Doctoral thesis, monograph (Other academic)
    Abstract [en]

    In Swedish dialects we find the terms ris, skäver and skärva referring to illnesses in children. The words are also parts of various compounds which refer to variants of the illnesses. The terms are linguistic expressions denoting two folk categories of illnesses, RIS and SKÄVER/SKÄRVA. These categories are investigated from a cognitive semantic perspective. The cognitive perspective argues that we organize our understanding of reality by using Idealized Cognitive Models (ICM) based on our physical, mental and emotional experiences of the world. The aim is twofold: to demonstrate the bases on which an experienced illness is placed in a certain category, and to show how a folk conception of illness is reflected in the word formation strategies. The word formation strategies emanate from notions of characteristic symptoms, and from notions of causes of illnesses. Both categories, RIS and SKÄVER/SKÄRVA, are based on a number of ICM's. The category RIS is a radial structure, which means that the category is held together although its members have no structural criteria in common. The category SKÄVER/SKÄRVA is a concentrating structure, meaning that all members share all structural criteria. There is a strong connection between word formation strategies and the structures of the categories. Terms related to symptoms refer to members of a category which are part of a radial structure, while terms related to causes refer to members of a category which are part of a concentrating structure. This can be explained by two of the basic assumptions of cognitive semantics: semantic content is structred and symbolized overtly on the surface form of a language and categories are conventional, based on cultural assumptions about the world.

  • Andersson, Fredrik
    et al.
    Department of Economics, Lund University, Lund, Sweden; Research Institute of Industrial Economics (IFN), Stockholm, Sweden.
    Jordahl, Henrik
    Örebro University, Örebro University School of Business. Research Institute of Industrial Economics (IFN), Stockholm, Sweden, CESifo, Stockholm, Sweden, IZA, Bonn, Germany.
    Josephson, Jens
    Research Institute of Industrial Economics (IFN), Stockholm, Sweden; Stockholm Business School, Stockholm University, Stockholm, Sweden.
    Outsourcing Public Services: Contractibility, Cost, and Quality2019Report (Other academic)
    Abstract [en]

    We review the literature on public sector outsourcing to explore if the theoretical predictions from the incomplete contracts literature hold up to recent empirical evidence. Guided by theory, we arrange services according to the type and magnitude of their contractibility problems. The empirical studies point at rather favourable outsourcing outcomes, in terms of costs and quality, for services without severe contracting problems. The picture is more mixed for services with tougher contracting problems, with the weight of the evidence in favour of public provision. This difference between services is largely in line with the property-rights framework and theories of incomplete contracts.

  • Public defence: 2019-10-09 09:15 Häggsalen, Uppsala
    Sun, Rui
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Porous Amorphous Calcium Carbonate and Phosphate: Synthesis and Application2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The synthesis of porous amorphous calcium carbonate (ACC) and porous amorphous calcium phosphate (ACP) was developed in this thesis. Porous ACC with specific Brunauer–Emmett–Teller (BET) surface area of >350 m2/g was synthesized using a surfactant free approach. The high surface area of porous ACC was related to its nanostructure. Porous ACC was constructed with aggregated ACC nanoparticles that were less than 10 nm in diameter. The porosity and stability of porous ACC could be enhanced by introducing additives in the synthesis steps. The use of additives could also be used to control the crystallization of ACC to form vaterite particles with controllable morphologies. Porous ACC was tested as a drug carrier for two poorly soluble drugs (itraconazole and celecoxib). The porous ACC carrier was able to stabilize these drugs in their amorphous forms and enhance their release rate significantly when compared with the crystalline drug. Furthermore, porous ACC could also be used as a precursor/template for the synthesis of porous carbon. A porous carbon adsorbent with high uptake and high selectivity for greenhouse gases was produced. Porous ACP with a specific BET surface area of >400 m2/g was obtained by introducing phosphoric acid to the ACC suspension obtained during the synthesis of porous ACC. Similar to porous ACC, porous ACP was constructed of aggregated nanoparticles. ACP was found to be stable in ambient conditions for over 12 months and the stability could also be tailored by adjusting its composition. Porous ACP was cytocompatible and an effective drug carrier for alendronate - a bisphosphate drug for treatment of osteoporosis. The development of porous ACC and porous ACP as functional porous materials is summarized in this thesis.

  • Garberg, Björn
    et al.
    Swedish Transport Administration.
    Bengtsson, Magnus
    Swedish Transport Administration.
    Populärversion av Åtgärder för ökad andel godstransporter på järnväg och med fartyg: Redovisning av Regeringsuppdrag2019Report (Other (popular science, discussion, etc.))
    Abstract [sv]

    För att möta framtida utmaningar behöver andelen godstran-sporter på järnväg och med fartyg öka. Trafikverket har, som ansvarig myndighet för den långsiktiga infrastrukturplaneringen, en viktig roll för att ambitionerna ska kunna realiseras. Men transportuppläggens utformning påverkas av en rad olika faktorer och förutsättningarna ser olika ut. Regeringen har nu gett Trafikverket i uppdrag att belysa vad myndigheten kan göra för att förbättra förutsättningarna för godstransporter på järnväg och med fartyg.

    Trafikverket kan på en rad punkter vidta åtgärder som ger positiva effekter för godstransporter på järnväg och med fartyg och som ökar nyttjandegraden i järnvägssystemet. Ett fortsatt nära samarbete med aktörerna i transportkedjan är en förutsättning för att kunna nå en överflyttning på bredare front. En hel del arbeten pågår, men mer behöver göras.

  • Guan, Jikui
    et al.
    Umapathy, Ganesh
    Yamazaki, Yasuo
    Wolfstetter, Georg
    Mendoza-Garcia, Patricia
    Department of Medical Biochemistry and Cell Biology, Instititute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Pfeifer, Kathrin
    Mohammed, Ateequrrahman
    Hugosson, Fredrik
    Zhang, Hongbing
    Hsu, Amy W
    Halenbeck, Robert
    Hallberg, Bengt
    Palmer, Ruth H
    FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase2015In: eLIFE, E-ISSN 2050-084X, Vol. 4, article id e09811Article in journal (Refereed)
    Abstract [en]

    Aberrant activation of anaplastic lymphoma kinase (ALK) has been described in a range of human cancers, including non-small cell lung cancer and neuroblastoma (Hallberg and Palmer, 2013). Vertebrate ALK has been considered to be an orphan receptor and the identity of the ALK ligand(s) is a critical issue. Here we show that FAM150A and FAM150B are potent ligands for human ALK that bind to the extracellular domain of ALK and in addition to activation of wild-type ALK are able to drive 'superactivation' of activated ALK mutants from neuroblastoma. In conclusion, our data show that ALK is robustly activated by the FAM150A/B ligands and provide an opportunity to develop ALK-targeted therapies in situations where ALK is overexpressed/activated or mutated in the context of the full length receptor.

  • Public defence: 2019-09-26 15:00 Södrasalen (M1083), Växjö
    Nilsson, Josefin A.
    Linnaeus University, Faculty of Technology, Department of Forestry and Wood Technology.
    Juvenile birch in Sweden: Selected stem characteristics for interior and furniture applications2019Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    In response to the furniture industry’s growing demand for raw material, large volumes of juvenile silver birch and downy birch stems available from pre-commercial thinning operations in Sweden’s forests could offer solutions. However, such stems are not currently used on an industrial scale, and most research conducted on birch stems in general has neither focussed on young trees nor the potential use of the central stem part around the tree pith. The resulting lack of knowledge about the juvenile part of birch wood thus requires additional information about the material properties of birch, which could encourage its use for various purposes in the furniture and other industries.

    The initial literature review performed for this thesis has highlighted some properties of juvenile birch required for its use as a furniture material, as well as identified topics concerning the physical characteristics of juvenile birch about which knowledge is currently limited. Consequently, the objectives of this thesis were to explore some characteristics of juvenile birch—bark thickness, wood-to-bark bonding ratio after drying, variations in the density and width of growth rings, and anatomical growth response to fertilisation—in order to increase the knowledge.

    The material studied came from mixed birch and Norway spruce stands at two sites in southern Sweden, namely Asa and Toftaholm. The birch stems were naturally regenerated silver birch and downy birch, with breast height diameters between 30 and 83 mm. Fertilised and unfertilised silver birch trees were sampled at Toftaholm, whereas unfertilised stems of silver birch and downy birch were sampled at Asa. The characteristics of stems from the pith to bark (radial direction) and along the stem (longitudinal direction) were measured. The wood-to-bark bonding ratio on downy birch after drying was calculated as the percentage of the stem circumference with full contact between the wood and bark, while oven-dry density and basic wood density for silver birch were determined by using the water displacement method. The impact of ring width on wood density was statistically analysed, and an image analysis of the wood anatomy was conducted to elucidate their relationship.

    Amongst the results, bark thickness along the stem had the highest deviation in the section closest to the stump. Moreover, the wood-to-bark bonding ratio after drying measured for juvenile downy birch seemed to depend more on the stem’s diameter than the sampling height along the stem. Such results are relevant for processors seeking to estimate the volume of wood under the bark. The wood-to-bark bonding ratio was highest for diameters between 30 and 39 mm, and neither did that relationship correlate with the sampling height along the stem.

    Variation in wood density in the radial and longitudinal directions in juvenile silver birch suggested that such density negatively correlated with growth rate (ring width). That relationship held true for stems at each site and between the sites, irrespective of management or growing conditions. As expected, mean wood density was lower in fertilised trees than in unfertilised ones, and towards the bark, radial density increased more in trees that grew more slowly. At the same time, variation in longitudinal density in young silver birch trees was low. Quantitative wood anatomy studies confirmed that the fertilised juvenile birch had younger cambia, thinner cell walls, and fewer vessels per mm2 than unfertilised trees in the same diameter class.

    Overall, the knowledge generated in the study may facilitate the industrial use of juvenile birch stems and wood in interior and furniture applications. The role of wood anatomy in determining the mechanical performance of juvenile birch stems should be further examined, however, to possibly reveal new opportunities for the use of juvenile birch.

  • Thomas, Manu
    et al.
    SMHI, Research Department, Air quality.
    Devasthale, Abhay
    SMHI, Research Department, Atmospheric remote sensing.
    L'Ecuyer, Tristan
    Wang, Shiyu
    SMHI, Research Department, Climate research - Rossby Centre.
    Koenigk, Torben
    SMHI, Research Department, Climate research - Rossby Centre.
    Wyser, Klaus
    SMHI, Research Department, Climate research - Rossby Centre.
    Snowfall distribution and its response to the Arctic Oscillation: an evaluation of HighResMIP models in the Arctic using CPR/CloudSat observations2019In: Geoscientific Model Development, ISSN 1991-959X, E-ISSN 1991-9603, Vol. 12, no 8, p. 3759-3772Article in journal (Refereed)
  • Nilsson, E.
    et al.
    Li, K.
    Fridlund, J.
    Sulcius, S.
    Bunse, C.
    Karlsson, C. M. G.
    Lindh, Markus
    SMHI, Core Services.
    Lundin, D.
    Pinhassi, J.
    Holmfeldt, K.
    Genomic and Seasonal Variations among Aquatic Phages Infecting the Baltic Sea Gammaproteobacterium Rheinheimera sp. Strain BAL3412019In: Applied and Environmental Microbiology, ISSN 0099-2240, E-ISSN 1098-5336, Vol. 85, no 18, article id e01003-19Article in journal (Refereed)
  • Garberg, Björn
    et al.
    Swedish Transport Administration.
    Bengtsson, Magnus
    Swedish Transport Administration.
    Martini, Veronika
    Swedish Transport Administration.
    Åtgärder för ökad andel godstransporter på järnväg och med fartyg.: Redovisning av regeringsuppdrag2019Report (Other academic)
    Abstract [sv]

    Målsättningen att flytta godstransporter från väg till järnväg och sjöfart har på senare tid förtydligats och konkretiserats successivt från politiskt håll. Som ett led i det arbetet har Trafikverket fått i uppdrag av regeringen att:

    − Inventera vilka åtgärder som Trafikverket kan vidta som skapar förutsättningar för fler godstransporter på järnväg och med fartyg.

    − Redovisa förutsättningar för att utveckla de olika system som Trafikverket förvaltar så att de bättre beskriver infrastruktur för omlastning.

    − Utreda förutsättningarna för och ta fram förslag till åtgärder för att öka godstransporternas nyttjandegrad i järnvägssystemet, utan att det drabbar persontrafiken med tåg.