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  • Gestrelius, Sara
    et al.
    RISE, Swedish ICT, SICS, Decisions, Networks and Analytics lab.
    Aronsson, Martin
    RISE, Swedish ICT, SICS, Decisions, Networks and Analytics lab.
    Joborn, Martin
    RISE, Swedish ICT, SICS, Decisions, Networks and Analytics lab.
    Bohlin, Markus
    RISE, Swedish ICT, SICS, Decisions, Networks and Analytics lab.
    Towards a comprehensive model for track allocation and roll-time scheduling at marshalling yards2017Conference paper (Refereed)
    Abstract [en]

    This paper considers multi-stage train formation with mixed usage tracks at a marshalling yard without departure yard. A novel integer programming model for scheduling shunting tasks as well as allocating arrival yard tracks and classification bowl tracks is presented. By taking a comprehensive view of the marshalling yard operations, more effective schedules can be found, and a variety of characteristics can be optimised, including shunting work effort, number or cost of tracks, and shunting task start times. Two different objective functions are evaluated: minimising work effort in terms of wagon pull-backs and minimising track costs. A procedure for finding a hot-start solution with few wagon pull-backs is also presented. The proposed model is tested on real data from Sävenäs marshalling yard in Sweden. The results show that the method is able to return an optimal schedule for a planning period of 4 days if the hot-start solution is optimal or the remaining problem is tractable for the heuristics in CPLEX.

  • Drake, B
    et al.
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SIK – Svenska institutet för konserveringsforskning.
    Johansson, B
    Sensory evaluation of food : Annotated bibliography : Supplement 1968-1973.: Volume 11974Report (Refereed)
  • Gestrelius, Sara
    et al.
    RISE, Swedish ICT, SICS, Decisions, Networks and Analytics lab.
    Aronsson, Martin
    RISE, Swedish ICT, SICS, Decisions, Networks and Analytics lab.
    Teknisk slutrapport för FLTP: Framtidens LeveransTågplaneProcess2017Report (Other academic)
    Abstract [sv]

    Slutrapporten sammanfattar arbetet som gjorts i projektet FLTP-Framtidens LeveransTågplaneProcess. FLTP har utförts av RISE SICS AB på uppdrag av Trafikverket under åren 2014-2016. Syftet med projektet har varit att undersöka planeringsmetoder för att ta fram leveransåtagande i en tänkt framtida långtidsprocess när Successiv Planering är fullt genomfört. Projektet har tagit fram ett planeringskoncept där alla kördagars individuella trafiksituation beaktas, och matematiska modeller och heuristiker som kan stödja den föreslagna planeringsmetoden har utformats och testats. Rapporten presenterar övergripande de metoder, resultat och slutsatser som projektet levererat, och ger också sammanhang till projektets övriga publikationer. Slutrapporten presenterar även i stora drag de mål som projektet satte upp, samt till vilken grad dessa har uppfyllts.

  • Abdelraheem, Mohamed Ahmed
    et al.
    RISE, Swedish ICT, SICS.
    Alizadeh, Javad
    Alkhzaimi, Hoda A.
    Aref, Mohammad Reza
    Bagheri, Nasour
    Gauravaram, Praveen
    Improved Linear Cryptanalysis of reduced-round SIMON-32 and SIMON-482015Conference paper (Refereed)
    Abstract [en]

    In this paper we analyse two variants of SIMON family of light-weight block ciphers against linear cryptanalysis and present the best linear cryptanalytic results on these variants of reduced-round SIMON to date. We propose a time-memory trade-off method that finds differential/linear trails for any permutation allowing low Hamming weight differential/linear trails. Our method combines low Hamming weight trails found by the correlation matrix representing the target permutation with heavy Hamming weight trails found using a Mixed Integer Programming model representing the target differential/linear trail. Our method enables us to find a 17-round linear approximation for SIMON-48 which is the best current linear approximation for SIMON-48. Using only the correlation matrix method, we are able to find a 14-round linear approximation for SIMON-32 which is also the current best linear approximation for SIMON-32. The presented linear approximations allow us to mount a 23-round key recovery attack on SIMON-32 and a 24-round Key recovery attack on SIMON-48/96 which are the current best results on SIMON-32 and SIMON-48. In addition we have an attack on 24 rounds of SIMON-32 with marginal complexity.

  • Tiloca, Marco
    et al.
    RISE, Swedish ICT, SICS, Security Lab.
    Nikitin, Kirill
    RISE, Swedish ICT, SICS.
    Raza, Shahid
    RISE, Swedish ICT, SICS, Security Lab.
    Axiom - DTLS-based secure IoT group communication2017In: ACM Transactions on Embedded Computing Systems, ISSN 1539-9087, E-ISSN 1558-3465, Vol. 16, no 3Article in journal (Refereed)
    Abstract [en]

    This article presents Axiom, a DTLS-based approach to efficiently secure multicast group communication among IoT-constrained devices. Axiom provides an adaptation of the DTLS record layer, relies on key material commonly shared among the group members, and does not require one to perform any DTLS handshake. We made a proof-of-concept implementation of Axiom based on the tinyDTLS library for the Contiki OS and used it to experimentally evaluate performance of our approach on real IoT hardware. Results show that Axiom is affordable on resource-constrained platforms and performs significantly better than related alternative approaches.

  • Svensson, S
    RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Sveriges tekniska forskningsinstitut, SIK – Svenska livmedelsinstitutet.
    Wheat gluten: A review. Part 21983Report (Refereed)
  • Elsts, Atis
    et al.
    RISE, Swedish ICT, SICS, Computer Systems Laboratory.
    Duquennoy, Simon
    RISE, Swedish ICT, SICS, Computer Systems Laboratory.
    Competition: Adaptive Time-Slotted Channel Hopping2017In: Proceedings of the 2017 International Conference on Embedded Wireless Systems and Networks, ACM Press, 2017, 274-275 p.Conference paper (Refereed)
    Abstract [en]

    Time-Slotted Channel Hopping (TSCH) from the IEEE 802.15.4-2015 standard uses channel hopping to combat interference and frequency-selective fading. It has attracted large attention from the research community due to its properties: high reliability in terms of packet delivery rates, and increased predictability in terms of energy consumption and latency, as compared to commonly used low-power CSMA MAC protocols.

    This work makes use of the Contiki OS implementation of the TSCH protocol. We extend the standardized TSCH protocol with adaptive channel selection, adaptive time synchronization, and adaptive guard time selection to improve its energy efficiency and reliability properties.

  • Borg, Markus
    et al.
    RISE, Swedish ICT, SICS, Software and Systems Engineering Laboratory.
    Olsson, Thomas
    RISE, Swedish ICT, SICS, Software and Systems Engineering Laboratory.
    Svensson, John
    From LiDAR to Underground Maps via 5G - Business Models Enabling a System-of-Systems Approach to Mapping the Kankberg Mine2017Report (Other academic)
    Abstract [en]

    With ever-increasing productivity targets in mining operations, there is a growing interest in mining automation. The PIMM project addresses the fundamental challenge of network communication by constructing a pilot 5G network in the underground mine Kankberg. In this report, we discuss how such a 5G network could constitute the essential infrastructure to organize existing systems in Kankberg into a system-of-systems (SoS). In this report, we analyze a scenario in which LiDAR equipped vehicles operating in the mine are connected to existing mine mapping and positioning solutions. The approach is motivated by the approaching era of remote controlled, or even autonomous, vehicles in mining operations. The proposed SoS could ensure continuously updated maps of Kankberg, rendered in unprecedented detail, supporting both productivity and safety in the underground mine. We present four different SoS solutions from an organizational point of view, discussing how development and operations of the constituent systems could be distributed among Boliden and external stakeholders, e.g., the vehicle suppliers, the hauling company, and the developers of the mapping software. The four scenarios are compared from both technical and business perspectives, and based on trade-off discussions and SWOT analyses. We conclude our report by recommending continued research along two future paths, namely a closer cooperation with the vehicle suppliers, and further feasibility studies regarding establishing a Kankberg software ecosystem.

  • Kraus, Anja
    Freien Universität Berlin, Germany.
    Nihilismus, Sprache und Wahrnehmung: Zur Anthropologie Lacans und Merleau-Pontys2000Doctoral thesis, monograph (Other academic)
    Abstract [en]

    In my doctoral thesis, I diversify so-called deviant behavior of children by means of a critical concept of nihilism and lead them back to a certain intellectual origin, namely, to the idealistic thinking tradition, which leads to the Philosophy of Lack and Not. I see this philosophy in the theories of Lacan and Merleau-Pontys, diametrically opposed to the idealistic thinking tradition. Departing from the ineradicable non-consciousness of man, Merleau-Ponty works out the laws of perception and Lacan the laws of language. As I refer to these authors and to the Philosophy of Not, my investigation proceeds not simply from the human capacity to be educated, but from the fact that in certain cases this capacity is to be yet established. The Philosophy of Not, complemented by the methodology of a cartography of negative experiences developed by the artist Robert Smithson, open up new surprising theoretical approaches to (educational) practical challenges. Starting from the laws recognized by Merleau-Ponty and Lacan, an explanation and possible forms of dealing with nihilistic behavior can be derived.

  • Marcuse, Reinhard
    Studies on Rancidity in Salted Herring. Experiments with Antioxidants.1956Report (Refereed)
  • Tao, Liang
    et al.
    Peng, Lisheng
    Berntsson, Ronnie P. -A.
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
    Liu, Sai Man
    Park, SunHyun
    Yu, Feifan
    Boone, Christopher
    Palan, Shilpa
    Beard, Matthew
    Chabrier, Pierre-Etienne
    Stenmark, Pål
    Krupp, Johannes
    Dong, Min
    Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors2017In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, 53Article in journal (Refereed)
    Abstract [en]

    Botulinum neurotoxin B is a Food and Drug Administration-approved therapeutic toxin. However, it has lower binding affinity toward the human version of its major receptor, synaptotagmin II (h-Syt II), compared to mouse Syt II, because of a residue difference. Increasing the binding affinity to h-Syt II may improve botulinum neurotoxin B's therapeutic efficacy and reduce adverse effects. Here we utilized the bacterial adenylate cyclase two-hybrid method and carried out a saturation mutagenesis screen in the Syt II-binding pocket of botulinum neurotoxin B. The screen identifies E1191 as a key residue: replacing it with M/C/V/Q enhances botulinum neurotoxin B binding to human synaptotagmin II. Adding S1199Y/W or W1178Q as a secondary mutation further increases binding affinity. Mutant botulinum neurotoxin B containing E1191M/S1199Y exhibits similar to 11-fold higher efficacy in blocking neurotransmission than wild-type botulinum neurotoxin B in neurons expressing human synaptotagmin II, demonstrating that enhancing receptor binding increases the overall efficacy at functional levels. The engineered botulinum neurotoxin B provides a platform to develop therapeutic toxins with improved efficacy.

  • Witt, S. H.
    et al.
    Streit, F.
    Jungkunz, M.
    Frank, J.
    Awasthi, S.
    Reinbold, C. S.
    Treutlein, J.
    Degenhardt, F.
    Forstner, A. J.
    Heilmann-Heimbach, S.
    Dietl, L.
    Schwarze, C. E.
    Schendel, D.
    Strohmaier, J.
    Abdellaoui, A.
    Adolfsson, Rolf
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
    Air, T. M.
    Akil, H.
    Alda, M.
    Alliey-Rodriguez, N.
    Andreassen, O. A.
    Babadjanova, G.
    Bass, N. J.
    Bauer, M.
    Baune, B. T.
    Bellivier, F.
    Bergen, S.
    Bethell, A.
    Biernacka, J. M.
    Blackwood, D. H. R.
    Boks, M. P.
    Boomsma, D. I.
    Borglum, A. D.
    Borrmann-Hassenbach, M.
    Brennan, P.
    Budde, M.
    Buttenschon, H. N.
    Byrne, E. M.
    Cervantes, P.
    Clarke, T-K
    Craddock, N.
    Cruceanu, C.
    Curtis, D.
    Czerski, P. M.
    Dannlowski, U.
    Davis, T.
    de Geus, E. J. C.
    Di Florio, A.
    Djurovic, S.
    Domenici, E.
    Edenberg, H. J.
    Etain, B.
    Fischer, S. B.
    Forty, L.
    Fraser, C.
    Frye, M. A.
    Fullerton, J. M.
    Gade, K.
    Gershon, E. S.
    Giegling, I.
    Gordon, S. D.
    Gordon-Smith, K.
    Grabe, H. J.
    Green, E. K.
    Greenwood, T. A.
    Grigoroiu-Serbanescu, M.
    Guzman-Parra, J.
    Hall, L. S.
    Hamshere, M.
    Hauser, J.
    Hautzinger, M.
    Heilbronner, U.
    Herms, S.
    Hitturlingappa, S.
    Hoffmann, P.
    Holmans, P.
    Hottenga, J-J
    Jamain, S.
    Jones, I.
    Jones, L. A.
    Jureus, A.
    Kahn, R. S.
    Kammerer-Ciernioch, J.
    Kirov, G.
    Kittel-Schneider, S.
    Kloiber, S.
    Knott, S. V.
    Kogevinas, M.
    Landen, M.
    Leber, M.
    Leboyer, M.
    Li, Q. S.
    Lissowska, J.
    Lucae, S.
    Martin, N. G.
    Mayoral-Cleries, F.
    McElroy, S. L.
    McIntosh, A. M.
    McKay, J. D.
    McQuillin, A.
    Medland, S. E.
    Middeldorp, C. M.
    Milaneschi, Y.
    Mitchell, P. B.
    Montgomery, G. W.
    Morken, G.
    Mors, O.
    Muehleisen, T. W.
    Mueller-Myhsok, B.
    Myers, R. M.
    Nievergelt, C. M.
    Nurnberger, J. I.
    O'Donovan, M. C.
    Loohuis, L. M. O.
    Ophoff, R.
    Oruc, L.
    Owen, M. J.
    Paciga, S. A.
    Penninx, B. W. J. H.
    Perry, A.
    Pfennig, A.
    Potash, J. B.
    Preisig, M.
    Reif, A.
    Rivas, F.
    Rouleau, G. A.
    Schofield, P. R.
    Schulze, T. G.
    Schwarz, M.
    Scott, L.
    Sinnamon, G. C. B.
    Stahl, E. A.
    Strauss, J.
    Turecki, G.
    Van der Auwera, S.
    Vedder, H.
    Vincent, J. B.
    Willemsen, G.
    Witt, C. C.
    Wray, N. R.
    Xi, H. S.
    Tadic, A.
    Dahmen, N.
    Schott, B. H.
    Cichon, S.
    Noethen, M. M.
    Ripke, S.
    Mobascher, A.
    Rujescu, D.
    Lieb, K.
    Roepke, S.
    Schmahl, C.
    Bohus, M.
    Rietschel, M.
    Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia2017In: Translational Psychiatry, ISSN 2158-3188, E-ISSN 2158-3188, Vol. 7, e1155Article in journal (Refereed)
    Abstract [en]

    Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10−7) and PKP4 (P=8.67 × 10−7); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (rg=0.28 [P=2.99 × 10−3]), SCZ (rg=0.34 [P=4.37 × 10−5]) and MDD (rg=0.57 [P=1.04 × 10−3]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.

  • Lövstål, Eva
    et al.
    Kristianstad University, School of Health and Society, Avdelningen för Ekonomi och arbetsliv. Kristianstad University, Research environment Governance, Regulation, Internationalization and Performance (GRIP.
    Jontoft, Anne-Marie
    Kristianstad University, School of Health and Society, Avdelningen för Ekonomi och arbetsliv. Kristianstad University, Research environment Governance, Regulation, Internationalization and Performance (GRIP.
    Tensions at the intersection of management control and innovation: a literature review2017In: Journal of Management Control, ISSN 2191-4761, E-ISSN 2191-477X, Vol. 28, no 1, 41-79 p.Article in journal (Refereed)
    Abstract [en]

    This paper reviews 47 articles dealing with tensions at the intersection of management control and innovation. One purpose is to present the status of the research in the area in terms of types of articles, research methods, theoretical approaches, and tension-related terms used. A second purpose is to conceptually compare the use and interpretations of tension in the reviewed articles, as well as to systematically map and categorize highlighted competing demands. A third purpose is to suggest a tension-based framework. Among other characteristics and trends, the paper indicates an increased research interest in the issue of tensions during the review period (1991–2015). Although different theoretical approaches are adopted, the contingency approach is the most common. Furthermore, the review shows that several tension-related terms are used either alone or in parallel in the articles, often interchangeably and without clarifying their definitions. The tension-based framework presents four different types of tension: (1) inherent innovation-control tensions, (2) inherent management control tensions, (3) created management control tensions, and (4) decision-making tensions in innovation practices. The framework also suggests interpretations of and responses to tensions related to management control and innovation. Theoretically, the framework can enable a more precise debate that builds on previous research, since it clarifies potential ways to structure future research. From a practical point of view the presented framework can be helpful for managers dealing with tensions, by encouraging creative management control solutions that can enable innovation.

  • Nordström, Carl-Henrik
    et al.
    Koskinen, Lars-Owe
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
    Olivecrona, Magnus
    Aspects on the Physiological and Biochemical Foundations of Neurocritical Care2017In: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 8, 274Article, review/survey (Refereed)
    Abstract [en]

    Neurocritical care (NCC) is a branch of intensive care medicine characterized by specific physiological and biochemical monitoring techniques necessary for identifying cerebral adverse events and for evaluating specific therapies. Information is primarily obtained from physiological variables related to intracranial pressure (ICP) and cerebral blood flow (CBF) and from physiological and biochemical variables related to cerebral energy metabolism. Non-surgical therapies developed for treating increased ICP are based on knowledge regarding transport of water across the intact and injured blood-brain barrier (BBB) and the regulation of CBF. Brain volume is strictly controlled as the BBB permeability to crystalloids is very low restricting net transport of water across the capillary wall. Cerebral pressure autoregulation prevents changes in intracranial blood volume and intracapillary hydrostatic pressure at variations in arterial blood pressure. Information regarding cerebral oxidative metabolism is obtained from measurements of brain tissue oxygen tension (PbtO2) and biochemical data obtained from intracerebral microdialysis. As interstitial lactate/pyruvate (LP) ratio instantaneously reflects shifts in intracellular cytoplasmatic redox state, it is an important indicator of compromised cerebral oxidative metabolism. The combined information obtained from PbtO2, LP ratio, and the pattern of biochemical variables reveals whether impaired oxidative metabolism is due to insufficient perfusion (ischemia) or mitochondrial dysfunction. Intracerebral microdialysis and PbtO2 give information from a very small volume of tissue. Accordingly, clinical interpretation of the data must be based on information of the probe location in relation to focal brain damage. Attempts to evaluate global cerebral energy state from microdialysis of intraventricular fluid and from the LP ratio of the draining venous blood have recently been presented. To be of clinical relevance, the information from all monitoring techniques should be presented bedside online. Accordingly, in the future, the chemical variables obtained from microdialysis will probably be analyzed by biochemical sensors.

  • Smith, Elin Marianne
    et al.
    Kristianstad University, School of Health and Society, Avdelningen för Ekonomi och arbetsliv. Kristianstad University, Research environment Auditing, Organisation and Society (AOS). Kristianstad University, Research environment Governance, Regulation, Internationalization and Performance (GRIP.
    Thomasson, Anna
    Lund University.
    The use of the partnering concept for public–private collaboration: how well does it really work?In: Public Organization Review, ISSN 1566-7170, E-ISSN 1573-7098Article in journal (Refereed)
    Abstract [en]

    This paper critically scrutinizes the key success factors and tools described in the partnering literature by exploring how they are implemented in a public–private partnering collaboration. In addition to this the paper investigates to what extent these tools facilitate the relationship between the parties in a partnering process. The empirical data consist of two longitudinal case studies. Both cases are large and complex urban development projects in the Swedish water and sewage industry. The results from the cases were ambiguous and positive; as well, some negative outcomes were present. Further, the processes were in both cases far from easy and it required a lot of effort from the parties in the collaboration to make the collaboration work and establish a culture based on trust, especially higher up in the organization. As could be expected, the reality is thus far more complex and cumbersome than previous studies indicate.

  • Östberg, Wilhelm
    Stockholm University, Faculty of Social Sciences, Department of Human Geography.
    Bringing back the trees2017In: Kenya Past and Present, ISSN 0257-8301, no 44, 11-22 p.Article in journal (Other academic)
    Abstract [en]

    Anthropologist Wilhelm Östberg documents what happened when a small NGO went to West Pokot to encourage livestock herders to plant trees. 

  • Lange, Dale J.
    et al.
    Shahbazi, Mona
    Silani, Vincenzo
    Ludolph, Albert C.
    Weishaupt, Jochen H.
    Ajroud-Driss, Senda
    Fields, Kara G.
    Remanan, Rahul
    Appel, Stanley H.
    Morelli, Claudia
    Doretti, Alberto
    Maderna, Luca
    Messina, Stefano
    Weiland, Ulrike
    Marklund, Stefan L.
    Andersen, Peter M.
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience. Department of Neurology, Ulm University, Ulm, Germany.
    Pyrimethamine Significantly Lowers Cerebrospinal Fluid Cu/Zn Superoxide Dismutase in Amyotrophic Lateral Sclerosis Patients with SOD1 Mutations2017In: Annals of Neurology, ISSN 0364-5134, E-ISSN 1531-8249, Vol. 81, no 6, 837-848 p.Article in journal (Refereed)
    Abstract [en]

    Objective: Cu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1-transgenic animal models. Pyrimethamine produces dose-dependent SOD1 reduction in cell culture systems. A previous phase 1 trial showed pyrimethamine lowers SOD1 levels in leukocytes in patients with SOD1 mutations. This study investigated whether pyrimethamine lowered SOD1 levels in the cerebrospinal fluid (CSF) in patients carrying SOD1 mutations linked to familial amyotrophic lateral sclerosis (fALS/SOD1). Methods: A multicenter (5 sites), open-label, 9-month-duration, dose-ranging study was undertaken to determine the safety and efficacy of pyrimethamine to lower SOD1 levels in the CSF in fALS/SOD1. All participants underwent 3 lumbar punctures, blood draw, clinical assessment of strength, motor function, quality of life, and adverse effect assessments. SOD1 levels were measured in erythrocytes and CSF. Pyrimethamine was measured in plasma and CSF. Appel ALS score, ALS Functional Rating Scale-Revised, and McGill Quality of Life Single-Item Scale were measured at screening, visit 6, and visit 9. Results: We enrolled 32 patients; 24 completed 6 visits (18 weeks), and 21 completed all study visits. A linear mixed effects model showed a significant reduction in CSF SOD1 at visit 6 (p<0.001) with a mean reduction of 13.5% (95% confidence interval [CI] 58.4-18.5) and at visit 9 (p<0.001) with a mean reduction of 10.5% (95% CI55.2-15.8). Interpretation: Pyrimethamine is safe and well tolerated in ALS. Pyrimethamine is capable of producing a significant reduction in total CSF SOD1 protein content in patients with ALS caused by different SOD1 mutations. Further long-term studies are warranted to assess clinical efficacy.

  • Jörgren, F.
    et al.
    Johansson, Robert
    Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
    Arnadottir, H.
    Lindmark, G.
    The importance of rectal washout for the oncological outcome after Hartmann's procedure for rectal cancer: analysis of population-based data from the Swedish Colorectal Cancer Registry2017In: Techniques in Coloproctology, ISSN 1123-6337, E-ISSN 1128-045X, Vol. 21, no 5, 373-381 p.Article in journal (Refereed)
    Abstract [en]

    During rectal cancer surgery the bowel may contain viable, exfoliated cancer cells, a potential source for local recurrence (LR). The amount and viability of these cells can be reduced using intraoperative rectal washout, a procedure that reduces the LR risk after anterior resection. The aim of this study was to analyse the impact of washout on oncological outcome when performed in Hartmann's procedure (HP) for rectal cancer. A national cohort study on data for patients registered from 1995 to 2007 in the Swedish Colorectal Cancer Registry was carried out. The final analysis included patients belonging to TNM stages I-III who had undergone R0 HP with a registered 5-year follow-up. Multivariate analysis was performed. A total of 1188 patients were analysed (686 washout and 502 no washout). No differences were detected between the washout group and the no washout group concerning rates of LR [7% (49/686) vs. 10% (49/502); p = 0.13], distant metastasis (DM) [17% (119/686) vs. 18% (93/502); p = 0.65], and overall recurrence (OAR) [21% (145/686) vs. 24% (120/502); p = 0.29]. For both groups, the 5-year cancer-specific survival was below 50%. In multivariate analysis, washout neither decreased the risk of LR, DM, or OAR nor increased overall or the cancer-specific 5-year survival. The oncological outcome did not improve when washout was performed in HP for rectal cancer.

  • Holmlund, Petter
    et al.
    Umeå University, Faculty of Medicine, Department of Radiation Sciences.
    Johansson, Elias
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Qvarlander, Sara
    Umeå University, Faculty of Medicine, Department of Radiation Sciences.
    Wåhlin, Anders
    Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
    Ambarki, Khalid
    Umeå University, Faculty of Medicine, Department of Radiation Sciences.
    Koskinen, Lars-Owe D.
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Malm, Jan
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Eklund, Anders
    Umeå University, Faculty of Medicine, Department of Radiation Sciences.
    Human jugular vein collapse in the upright posture: implications for postural intracranial pressure regulation2017In: Fluids and Barriers of the CNS, ISSN 2045-8118, E-ISSN 2045-8118, Vol. 14, 17Article in journal (Refereed)
    Abstract [en]

    Background: Intracranial pressure (ICP) is directly related to cranial dural venous pressure (P-dural). In the upright posture, P-dural is affected by the collapse of the internal jugular veins (IJVs) but this regulation of the venous pressure has not been fully understood. A potential biomechanical description of this regulation involves a transmission of surrounding atmospheric pressure to the internal venous pressure of the collapsed IJVs. This can be accomplished if hydrostatic effects are cancelled by the viscous losses in these collapsed veins, resulting in specific IJV cross-sectional areas that can be predicted from flow velocity and vessel inclination. Methods: We evaluated this potential mechanism in vivo by comparing predicted area to measured IJV area in healthy subjects. Seventeen healthy volunteers (age 45 +/- 9 years) were examined using ultrasound to assess IJV area and flow velocity. Ultrasound measurements were performed in supine and sitting positions. Results: IJV area was 94.5 mm(2) in supine and decreased to 6.5 +/- 5.1 mm(2) in sitting position, which agreed with the predicted IJV area of 8.7 +/- 5.2 mm(2) (equivalence limit +/- 5 mm(2), one-sided t tests, p = 0.03, 33 IJVs). Conclusions: The agreement between predicted and measured IJV area in sitting supports the occurrence of a hydrostatic-viscous pressure balance in the IJVs, which would result in a constant pressure segment in these collapsed veins, corresponding to a zero transmural pressure. This balance could thus serve as the mechanism by which collapse of the IJVs regulates P-dural and consequently ICP in the upright posture.

  • Backman, Helena
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
    Hedman, Linnea
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine. Department of Health Sciences, Luleå University, Luleå, Sweden.
    Stridsman, Caroline
    Jansson, Sven-Arne
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
    Lindberg, Anne
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Lundbäck, Bo
    Rönmark, Eva
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
    A population-based cohort of adults with asthma: mortality and participation in a long-term follow-up2017In: European Clinical Respiratory Journal, ISSN 2001-8525, Vol. 4, 1334508Article in journal (Refereed)
    Abstract [en]

    Background and objective: Asthma is a major public health concern. The aim of this study was to characterize a large population-based cohort of adults with asthma, and to study factors associated with all-cause mortality and non-participation in a long-term follow-up. Design: Random and stratified samples from five population-based cohorts were clinically examined during 1986-2001, and all subjects with asthma were included in the study (n = 2055, age 19-72 years, 55% women). Independent associations between different risk factors and (i) mortality and (ii) non-participation in a clinical follow-up in 2012-2014 were estimated. Results: In 1986-2001, 95% reported any wheeze and/or attacks of shortness of breath in the past 12 months, and/or asthma medication use. Over the up to 28 years of follow-up time, the cumulative mortality was 22.7%. Male gender, current smoking, and lower forced expiratory volume in 1 sec of predicted (FEV1% of predicted) were independent risk factors for mortality, while obesity was associated with non-participation in the follow-up. Older ages, ischemic heart disease, and low socioeconomic status were associated with both mortality and non-participation. Conclusions: The risk factors associated with mortality in this adult population-based asthma cohort were similar to those commonly identified in general population samples, i.e. male gender, current smoking, and lower FEV1% of predicted, while obesity was associated with non-participation in a long-term follow-up. Ischemic heart disease, low socioeconomic status, and older ages were associated with both mortality and non-participation.

  • Slupsky, Carolyn M.
    et al.
    He, Xuan
    Hernell, Olle
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
    Andersson, Yvonne
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
    Rudolph, Colin
    Lönnerdal, Bo
    West, Christina E.
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
    Postprandial metabolic response of breast-fed infants and infants fed lactose-free vs regular infant formula: a randomized controlled trial2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 3640Article in journal (Refereed)
    Abstract [en]

    Lactose intolerance is a major concern driving the growth of lactose-free foods including lactose-free infant formula. It is unknown what the metabolic consequence is of consumption of a formula where lactose has been replaced with corn syrup solids (CSS). Here, a randomized double-blinded intervention study was conducted where exclusively formula-fed infants were fed formula containing either lactose or CSS-based infant formula and compared with an equal number of exclusively breast-fed infants. Plasma metabolites and insulin were measured at baseline, 15, 30, 60, 90 and 120 min after feeding. Differences in plasma metabolite profiles for formula-fed infants included a rapid increase in circulating amino acids, creatinine and urea compared with breast-fed infants. At 120 min post-feeding, insulin was significantly elevated in formula-fed compared with breast-fed infants. Infants fed lactose-based formula had the highest levels of glucose at 120 min, and leucine, isoleucine, valine and proline at 90 and 120 min, whereas infants fed CSS-based formula had the lowest levels of non-esterified fatty acids at all time points, and glucose at 120 min. Overall, these differences highlight that changes in infant formula composition impact infant metabolism, and show that metabolomics is a powerful tool to help with development of improved infant formulas.

  • Do Yi, Su
    et al.
    Noh, Jae Dong
    Minnhagen, Petter
    Umeå University, Faculty of Science and Technology, Department of Physics.
    Song, Mi-Young
    Chon, Tae-Soo
    Kim, Beom Jun
    Human bipedalism and body-mass index2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 3688Article in journal (Refereed)
    Abstract [en]

    Body-mass index, abbreviated as BMI and given by M/H2 with the mass M and the height H, has been widely used as a useful proxy to measure a general health status of a human individual. We generalise BMI in the form of M/Hp and pursue to answer the question of the value of p for populations of animal species including human. We compare values of p for several different datasets for human populations with the ones obtained for other animal populations of fish, whales, and land mammals. All animal populations but humans analyzed in our work are shown to have p ≈ 3 unanimously. In contrast, human populations are different: As young infants grow to become toddlers and keep growing, the sudden change of p is observed at about one year after birth. Infants younger than one year old exhibit significantly larger value of p than two, while children between one and five years old show p ≈ 2, sharply different from other animal species. The observation implies the importance of the upright posture of human individuals. We also propose a simple mechanical model for a human body and suggest that standing and walking upright should put a clear division between bipedal human (p ≈ 2) and other animals (p ≈ 3).

  • Andersson, Therese
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Söderberg, Stefan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Incidence of acute pulmonary embolism, related comorbidities and survival: analysis of a Swedish national cohort2017In: BMC Cardiovascular Disorders, ISSN 1471-2261, E-ISSN 1471-2261, Vol. 17, 155Article in journal (Refereed)
    Abstract [en]

    Background: The aim of the study was to determine the incidence of acute pulmonary embolism (PE) in Sweden and any regional differences. To assess short-and long-term survival analysis after an episode of PE, before and after excluding patients with known malignancies, and to determine the most common comorbidities prior to the PE event. Methods: All in-hospital patients, including children, diagnosed with acute PE in 2005 were retrieved from the Swedish National Patient Registry (NPR) and incidence rates were calculated. All registered comorbidities from 1998 until the index events were collected and survival up to 4 years after the event were calculated and compared to matched controls. Results: There were 5793 patients of all ages diagnosed with acute PE in 2005 resulting in a national incidence of 0.6/1000/year. The mean age was 70 years and 52% were women. The most frequent comorbidities were cardiac-, vascular-, infectious-and gastrointestinal diseases, injuries and malignancies. The mortality rates were more than doubled in patients with recent PE compared to that in a matched control group (49.1% vs 21.9%), and the excess mortality remained after exclusion of deaths occurring within one year and after exclusion of patients with any malignancy prior to the event. Conclusions: PE is associated with high age as well as with multiple comorbidities, and with an increased shortand long-term mortality. This study highlights the importance of a proper follow-up after an acute PE.

  • Alfredsson, Maria
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    San Sebastian, Miguel
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Jeghannathan, Bhoomikumar
    Attitudes towards mental health and the integration of mental health services into primary health care: a cross-sectional survey among health-care workers in Lvea Em District, Cambodia2017In: Global Health Action, ISSN 1654-9716, E-ISSN 1654-9880, Vol. 10, 1331579Article in journal (Refereed)
    Abstract [en]

    Background: Cambodia is a country where the resources for treating mental health disorders are far from sufficient. One strategy to narrow the treatment gap is to integrate mental health into primary health care (PHC). Understanding the knowledge and attitudes towards mental health integration that health-care workers have is important for assessing the challenges and opportunities when planning a potential integration project. Objective: The aim of this study was to assess these basic conditions in Lvea Em District, Cambodia. Design: A structured self-reporting questionnaire regarding attitudes and knowledge about mental health and its integration into PHC was collected from 75 health-care workers in Lvea Em District, Cambodia in October 2015. Firstly, descriptive analyses were carried out, and secondly, linear regression analyses to assess the relationship between attitudes and socio-demographic variables were conducted. Results: There was clear support towards integrating mental health services into PHC among these participants as 81.3% were interested in personally delivering mental health care at their units. Respondents who reported having received some kind of mental health-care training tended to have a more positive attitude towards mentally ill people (p = 0.005) and those who thought there was a high need for mental health care had a more favourable attitude towards the integration of mental health services (p = 0.007). Conclusions: The most important finding from this survey was the willingness and the acceptance of the need for integration of mental health care. This enhances the feasibility of integrating mental health services at the PHC level. Improving the competence of mental health care in these settings will likely help to reduce the treatment gap for mental, neurological and substance use disorders in Cambodia.

  • Bringsén, Åsa
    Kristianstad University, School of Health and Society, Avdelningen för Oral hälsa och folkhälsovetenskap. Kristianstad University, Forskningsmiljön Människa - Hälsa - Samhälle (MHS). Kristianstad University, Research Platform for Collaboration for Health. Kristianstad University, School of Health and Society, Avdelningen för Samhällsvetenskap.
    Idrottskonsulenter diskuterar följeforskningens resultat2016In: Framtidens motionsidrott: möjligheter och utmaningar / [ed] Åsa Bringsén, Kristianstad: Kristianstad University Press , 2016, 57-62 p.Chapter in book (Other (popular science, discussion, etc.))
  • Andersson, Ida
    et al.
    Kristianstad University, School of Health and Society.
    Eskesjö, Jimmy
    Kristianstad University, School of Health and Society.
    FMI deltagare – motivation till motionsidrott2016In: Framtidens motionsidrott: möjligheter och utmaningar / [ed] Åsa Bringsén, Kristianstad: Kristianstad University Press , 2016, 44-48 p.Chapter in book (Other (popular science, discussion, etc.))
  • Bringsén, Åsa
    Kristianstad University, School of Health and Society, Avdelningen för Oral hälsa och folkhälsovetenskap. Kristianstad University, Forskningsmiljön Människa - Hälsa - Samhälle (MHS). Kristianstad University, Research Platform for Collaboration for Health. Kristianstad University, School of Health and Society, Avdelningen för Samhällsvetenskap.
    Deltagande föreningar, ledarnivå – beskrivning av verksamhet och uppfattning om motionsidrott2016In: Framtidens motionsidrott: möjligheter och utmaningar / [ed] Åsa Bringsén, Kristianstad: Kristianstad University Press , 2016, 27-43 p.Chapter in book (Other (popular science, discussion, etc.))
  • Bringsén, Åsa
    Kristianstad University, School of Health and Society, Avdelningen för Oral hälsa och folkhälsovetenskap. Kristianstad University, Forskningsmiljön Människa - Hälsa - Samhälle (MHS). Kristianstad University, Research Platform for Collaboration for Health. Kristianstad University, School of Health and Society, Avdelningen för Samhällsvetenskap.
    Deltagande föreningar, styrelsenivå – beskrivning av verksamhet och uppfattning om motionsidrott2016In: Framtidens motionsidrott: möjligheter och utmaningar / [ed] Åsa Bringsén, Kristianstad: Kristianstad University Press , 2016, 13-26 p.Chapter in book (Other (popular science, discussion, etc.))
  • Bringsén, Åsa
    Kristianstad University, School of Health and Society, Avdelningen för Oral hälsa och folkhälsovetenskap. Kristianstad University, Forskningsmiljön Människa - Hälsa - Samhälle (MHS). Kristianstad University, Research Platform for Collaboration for Health. Kristianstad University, School of Health and Society, Avdelningen för Samhällsvetenskap.
    Delprojekt – sammanfattandebeskrivning av FMI projekten2016In: Framtidens motionsidrott: möjligheter och utmaningar / [ed] Åsa Bringsén, Kristianstad: Kristianstad University Press , 2016, 9-12 p.Chapter in book (Other (popular science, discussion, etc.))
  • Olsson, Ann-Margreth E.
    Kristianstad University, Research Environment Children's and Young People's Health in Social Context (CYPHiSCO). Kristianstad University, Research Platform for Collaboration for Health. Kristianstad University, School of Health and Society, Avdelningen för Ekonomi och arbetsliv.
    Barn i svenska ”militära familjer”: barns berättelser om hur de reder sig när förälder åker iväg som svensk soldat på utlandsmission2017In: Barnsliga sammanhang: forskning om barns och ungdomars hälsa, välbefinnande och delaktighet / [ed] Bo Nilsson & Eva Clausson, Kristianstad: Kristianstad University Press , 2017, 51-63 p.Chapter in book (Other academic)
  • Basic, Goran
    Linnaeus University, Faculty of Social Sciences, Department of pedagogy.
    Observed Coherent Triads in Swedish Social Work Practice. Analysis of Observed Successful Collaboration Beneficial for Clients in Swedish Juvenile Care2017In: BOOK of ABSTRACTS, EUSSSI 2017, The 8th Conference of the European Society for the Study of Symbolic Interaction Studying Everyday Life: Generic Dimensions of Interactionist Inquiry, Lodz, Poland, 2017, 9-10 p.Conference paper (Refereed)
    Abstract [en]

    Previous research on collaboration in social work practice shows that conflicts among collaborating authorities and organizations and that include cooperating actors are common. In this study, I have analyzed a successful dimension of the phenomenon “cooperation.” The purpose of the study is to analyze examples of successful cooperation in Swedish social work practice. This study presents an analysis of factors of “successful collaboration” as described in the field notes of the study and that can be interpreted as beneficial for the youth in question. A total of 119 field observations of organized and informal meetings form the empirical basis for this study. The observations took place before and after these meetings and during visits to youth care institutions in Sweden, social services offices, and the Swedish National Board of Institutional Care. The factors used in the empirical material of this study serve to define successful cooperation that makes visible actors belonging to at least three different categories (coherent triad in the collaborative act). Constructing and reconstructing a collaboration success is a dynamic, interactive process. Coherent triads and success points of interest that are beneficial for the young person in the situation also create the image of a positive development for the young person. In this way, common identities of interplay that are useful for the young person are being created and elucidated. The physical presence of the young person in these situations is especially important factor for the “successful collaboration.” 

  • Basic, Goran
    et al.
    Linnaeus University, Faculty of Social Sciences, Department of pedagogy. Lund University.
    Wästerfors, David
    Lund University.
    Hugo, Martin
    Jönköping University.
    Ekberg, Margareta Stigsdotter
    Linnaeus University, Faculty of Social Sciences, Department of pedagogy.
    Alm, Maria
    Linnaeus University, Faculty of Social Sciences, Department of pedagogy.
    Wahlgren, Paula
    Linnaeus University, Faculty of Social Sciences, Department of pedagogy.
    School as a protection factor: An analysis of achievements, obstacles, collaboration, and identities in senior high school work with students who use alcohol and drugs2017In: BOOK OF ABSTRACTS. The 9th International Conference of the Faculty of Education and Rehabilitation Sciences University of Zagreb / [ed] Gordana Hržica; Ivana Jeđud Borić, Zagreb, 2017, 192-193 p.Conference paper (Refereed)
    Abstract [en]

    This research project is inspired by ethnographic methodology, where researchers reside within the environments, situations, and interactions they want to learn about. By observing what happens, listening to what is said, asking questions and collecting documents in the practice, the researcher can come to an understanding of the participantsʼ experiences. Adolescence is a unique period in which there is a high potential to influence and change both issues at school and drug abuse problems. However, it may require productive collaboration between professional in the social services and treatment centers and school staff. The environment at school can help create stability in a drug-abusing youths’ life, and the combination of education and treatment is a key factor necessary for these students to build independence. Much remains unknown about improving schooling for students with alcohol and drug problems and the factors involved should therefore be investigated. This project aims to identify and analyze (1) factors in practical and organizational work at senior high schools that are obstructive and promotive to students with alcohol and drug problems; (2) the circumstances teachers and other professional actors in the Swedish school system need to promote the success of students with alcohol and drug problems; (3) implications of school attendance for inclusion, learning, and change in these youths; and (4) implications for the identity construction of these young people related to school situations. By examining the details of the work done by professionals, the results from this project will provide missing knowledge about how to improve schooling for young people with alcohol and drug problems and how this contributes to their inclusion and participation in society. Our hope is that the project will identify conditions and opportunities needed to support young people with alcohol and drug problems in senior high school. Additionally, the information obtained will be used to develop a model for improved collaboration between schools, social services, and various treatment services to improve graduation rates for young people in the target group. In this specific target group, studies are lacking that identify factors that promote or obstruct such cooperation. 

  • Cronquist, Björn
    Kristianstad University, School of Education and Environment, Avdelningen för Naturvetenskap.
    The quest for intelligence in SME´s: acting on external information by development of internal practices2008In: 5th International Conference on Intellectual Capital, Knowledge Management and Organisational Learning: New York Institute of Technology, New York, USA, 9-10 October 2008 / [ed] Kevin O'Sullivan, Reading: Academic Publishing Limited , 2008, 129-136 p.Conference paper (Refereed)
    Abstract [en]

    Organizational Intelligence (OI) focuses particularly on the systematic processing of information from external sources in order to enhance the ability to foresee the future and to adapt to changes in the environment. Traditionally this pursuit of intelligence has been regarded as a central organizational function focusing on information retrieval and information provision. OI has also been regarded as an issue mainly reserved for the larger companies. In pace with the development of global markets even for small and medium sized enterprises (SME), the urge for Organizational Intelligence (OI) in these companies is increasing. This paper presents a model for describing how intelligence is obtained in successful SME´s. The model is evaluated and tested through case based reasoning towards a framework for describing OI in SME´s.

    This research explores OI from a different perspective in promoting a more action-directed approach investigating how organizational intelligence is expressed in organizational processes and routines. The core contribution from the work presented is that OI in SME´s is effectively explained by the contribution from motivated knowledge workers commitment to organizational intelligence activities as expressed in knowledge management practices. This statement is supported by an empirical investigation which is built on a case study of a successful company, Bend&Weld Ltd, showing rapid, sustainable and profitable growth. The case of Bend&Weld address the main question; How can the pursuit of Organizational Intelligence in successful small and medium sized enterprises be explained and described? , supported by the sub questions; How can individual knowledge workers spontaneous environmental scanning support Organizational Intelligence? , and, What role can routines and procedures play in the pursuit of Organizational Intelligence? The findings demonstrate that organizational intelligence is not limited to an information processing function but rather should be viewed as an outcome of planned knowledge management practices constituting core organizational business processes. SME´s recognize the need to be attentive to their environments but are not aware nor can describe in what way they are pursuing intelligence. The result of a five year research project presents a model to describe and understand the pursuit of intelligence in SME´s.

  • Lidberg, Tina
    et al.
    Dalarna University, School of Technology and Business Studies, Energy Technology.
    Swing Gustafsson, Moa
    Dalarna University, School of Technology and Business Studies, Energy Technology. KTH.
    Myhren, Jonn Are
    Dalarna University, School of Technology and Business Studies, Construction.
    Olofsson, Thomas
    Dalarna University, School of Technology and Business Studies, Energy Technology. Umeå universitet.
    Trygg, L.
    Comparing different building energy efficiency refurbishment packages performed within different district heating systems2017In: Energy Procedia, ISSN 1876-6102, E-ISSN 1876-6102, Vol. 105, 1719-1724 p.Article in journal (Refereed)
    Abstract [en]

    This study analyses the differences in primary energy (PE) use of a multi-family building refurbished with different refurbishment packages situated in different district heating systems (DHS). Four models of typical DHS are defined to represent the Swedish DH sector. The refurbishment packages are chosen to represent typical, yet innovative ways to improve the energy efficiency of a representative multi-family building in Sweden. The study was made from a broad system perspective, including valuation of changes in electricity use on the margin. The results show a significant difference in PE savings for the different refurbishment packages, depending on both the package itself as well as the type of DHS. Also, the package giving the lowest specific energy use per m2 was not the one which saved the most PE. © 2017 The Authors.

  • Public defence: 2017-08-25 10:00 F3, Stockholm
    Wu, Qiong
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Biofoams and Biocomposites based on Wheat Gluten Proteins2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Novel uses of wheat gluten (WG) proteins, obtained e.g. as a coproduct from bio-ethanol production, are presented in this thesis. A flame-retardant foam was prepared via in-situ polymerization of hydrolyzed tetraethyl orthosilicate (TEOS) in a denatured WG matrix (Paper I). The TEOS formed a well-dispersed silica phase in the walls of the foam. With silica contents ≥ 6.7 wt%, the foams showed excellent fire resistance. An aspect of the bio-based foams was their high sensitivity to fungi and bacterial growth. This was addressed in Paper II using a natural antimicrobial agent Lanasol. In the same paper, a swelling of 32 times its initial weight in water was observed for the pristine WG foam and both capillary effects and cell wall absorption contributed to the high uptake. In Paper III, conductive and flexible foams were obtained using carbon-based nanofillers and plasticizer. It was found that the electrical resistance of the carbon nanotubes and carbon black filled foams were strain-independent, which makes them suitable for applications in electromagnetic shielding (EMI) and electrostatic discharge protection (ESD). Paper IV describes a ‘water-welding’ method where larger pieces of WG foams were made by wetting the sides of the smaller cubes before being assembled together. The flexural strength of welded foams was ca. 7 times higher than that of the same size WG foam prepared in one piece. The technique provides a strategy for using freeze-dried WG foams in applications where larger foams are required.

    Despite the versatile functionalities of the WG-based materials, the mechanical properties are often limited due to the brittleness of the dry solid WG. WG/flax composites were developed for improved mechanical properties of WG (Paper V). The results revealed that WG, reinforced with 19 wt% flax fibres, had a strength that was ca. 8 times higher than that of the pure WG matrix. Furthermore, the crack-resistance was also significantly improved in the presence of the flax.

  • Liu, Peng
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Applied Physical Chemistry. kTH.
    Gardner, James
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Applied Physical Chemistry.
    Kloo, Lars
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Applied Physical Chemistry.
    Cross-linked sulfur-selenium polymers as hole transporting materials in dye-sensitized solar cells and perovskite solar cells,2017In: ChemphotoChemArticle in journal (Refereed)
    Abstract [en]

    Novel inverse-vulcanized polymeric sulfur–selenium materials (SeS2:S:DIB, where DIB=1,3-diisopropenylbenzene) have been prepared and utilized for solid-state dye-sensitized solar cellsand perovskite solar cells. Under standard AM 1.5G illumination (1000 Wm-2), a power conversion efficiency of 1.70% was recorded for polymeric sulfur–selenium–based (SeS2:S:DIB) solidstate solar cells, which is higher than that of polymeric sulfurbased (S:DIB) devices (1.09 %). For perovskite solar cells, a relatively high efficiency has been achieved for polymeric sulfur–selenium-based (SeS2:S:DIB) solar cells (10.21%) and polymeric sulfur-based (S:DIB; 7.32%) solar cells, respectively. The conductivity of the polymeric SeS material has been determined to 2.2410-4 Scm-1, which is higher than for the polymeric sulfur material under the same doping conditions. Photoinduced absorption and steady-state photoluminescence measurements were performed to investigate the charge-transfer properties relevant for the solar cells. The results in the present study qualify the new polymeric sulfur–selenium materials as candidates for low-cost hole-transport materials for photovoltaic devices.

  • Liu, Peng
    et al.
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Applied Physical Chemistry. kTH.
    Sharmoukh, Walid
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Xu, Bo
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
    Li, Yuanyuan
    KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.
    Boschloo, Gerrit
    Uppsala University.
    Sun, Licheng
    KTH, School of Chemical Science and Engineering (CHE), Chemistry. Dalian University of Technology (DUT), Dalian, China.
    Kloo, Lars
    KTH, School of Chemical Science and Engineering (CHE), Chemistry, Applied Physical Chemistry.
    Novel and Stable D-A-π-A Dyes for Efficient Solid-state Dye-sensitized Solar Cells2017In: ACS Omega, Vol. 2, no 5, 1812-1819 p.Article in journal (Refereed)
    Abstract [en]

    Two novel organic donor–acceptor−π–acceptor sensitizers, W7 and W8, have been applied in efficient solid-state dye-sensitized solar cells (ssDSSCs). Using 2,2′,7,7′-tetrakis(N,N-di-p-methoxyphenyl-amine) 9,9′-spirobifluorene (Spiro-OMeTAD) as hole-transport material (HTM), an excellent power conversion efficiency of 6.9% was recorded for W7, together with an excellent photocurrent of 10.51 mA cm–2 and a high open-circuit voltage of 880 mV under standard AM 1.5 G illumination (100 mW cm–2). The solid-state solar cells based on W8 showed an efficiency of 5.2%, with a good photocurrent of 9.55 mA cm–2 and an open-circuit voltage of 870 mV. Compared to that of the well-known WS2 sensitizer, the results show that the performance of the ssDSSC devices can be significantly improved by introducing triphenylamine moiety into their structure. In addition, results of photoinduced absorption spectroscopy show efficient dye regeneration for W7- and W8-based devices. A higher hole conductivity of the W7/HTM and W8/HTM layers compared to that of the WS2/HTM layer was observed, indicating an efficient charge transfer at the interfaces. The results obtained offer insights into the design of reliable and highly efficient ssDSSCs for large-scale applications.

  • Sundh, Josefin
    et al.
    Örebro Univ, Sch Med Sci, Dept Resp Med, Örebro, Sweden..
    Lindgren, Helena
    Örebro Univ, Med Programme, Sch Med Sci, Örebro, Sweden..
    Hasselgren, Mikael
    Örebro Univ, Med Programme, Sch Med Sci, Örebro, Sweden..
    Montgomery, Scott
    Örebro Univ, Clin Epidemiol & Biostat, Sch Med Sci, Örebro, Sweden.;Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden.;UCL, Dept Epidemiol & Publ Hlth, London, England..
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Ställberg, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Lisspers, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Pulmonary rehabilitation in COPD - available resources and utilization in Swedish primary and secondary care2017In: The International Journal of Chronic Obstructive Pulmonary Disease, ISSN 1176-9106, E-ISSN 1178-2005, Vol. 12, 1695-1704 p.Article in journal (Refereed)
    Abstract [en]

    Introduction: Pulmonary rehabilitation is effective in all stages of COPD. The availability and utilization of pulmonary rehabilitation resources, and the characteristics of COPD patients receiving rehabilitation, were investigated in primary and secondary care in central Sweden. Materials and methods: Data on available pulmonary rehabilitation resources were collected using questionnaires, to 14 hospitals and 54 primary health care centers, and information on utilization of different rehabilitation professionals was obtained from questionnaires completed by 1,329 COPD patients from the same centers. Multivariable logistic regression examined associations with having received rehabilitation in the previous year. Results: In primary care, nurse- based asthma/COPD clinics were common (87%), with additional separate access to other rehabilitation professionals. In secondary care, rehabilitation was more often offered as part of a multidisciplinary teamwork (71%). In total, 36% of the patients met an asthma/COPD nurse in the previous year. Utilization was lower in primary than in secondary care for physiotherapists (7% vs 16%), occupational therapists (3% vs 10%), nutritionists (5% vs 13%), and counselors (1% vs 4%). A higher COPD Assessment Test score and frequent exacerbations were associated with higher utilization of all rehabilitation professionals. Conclusion: Pulmonary rehabilitation resources are available but underutilized, and receiving rehabilitation is more common in severe COPD. Treatment recommendations need to be better implemented, especially in mild and moderate COPD.

  • Monteagudo, Celia
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Food, Nutrition and Dietetics. Univ Granada, Dept Nutr & Food Sci, Res Grp Nutr Diet & Risk Assessment AGR255, Granada, Spain..
    Scander, Henrik
    Örebro Univ, Sch Hospitality Culinary Arts & Meal Sci, Örebro, Sweden..
    Nilsen, Bente
    Örebro Univ, Sch Hospitality Culinary Arts & Meal Sci, Örebro, Sweden..
    Yngve, Agneta
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Food, Nutrition and Dietetics.
    Folate intake in a Swedish adult population: Food sources and predictive factors2017In: Food & Nutrition Research, ISSN 1654-6628, E-ISSN 1654-661X, Vol. 61, no 1, 1328960Article in journal (Refereed)
    Abstract [en]

    Introduction: Folate plays an important role in cell metabolism, but international studies show that intake is currently below recommendations, especially among women. The study objective was to identify folate food sources by food group, gender, and age group, and to identify factors influencing folate intake, based on food consumption data for Swedish adults in the 2010-11 Riksmaten study.

    Methods: The sample included a representative Swedish population aged 18-80 years (n = 1657; 56.3% female). Food and nutrient intakes were estimated from self-reported food records during 4 consecutive days. Food consumption was categorized into 26 food groups. Stepwise regression was used to analyze food groups as folate sources for participants. Factors predicting the highest folate intake (third tertile) were determined by logistic regression analysis.

    Results: Vegetables and pulses represented the most important folate source for all age groups and both genders, especially in women aged 45-64 years (49.7% of total folate intake). The next folate source in importance was dairy products for the youngest group (18-30 years), bread for men, and fruit and berries for women. The likelihood of being in the highest tertile of folate intake (odds ratio = 1.69, 95% confidence interval 1.354-2.104) was higher for men. Influencing factors for folate intake in the highest tertile were low body mass index and high educational level in the men, and high educational level, vegetarian diet, organic product consumption, nonsmoking, and alcohol consumption within recommendations in the women.

    Conclusion: This study describes the folate intake per food group of Swedish adults according to the 2010-11 Riksmaten survey, identifying vegetables and pulses as the most important source. Data obtained on factors related to folate consumption may be useful for the development of specific nutrition education programs to increase the intake of this vitamin in high-risk groups.

  • Fråne, Anna
    et al.
    Askham, Cecilia
    Gíslason, Stefán
    Kiørboe, Nikola
    Ljungkvist, Hanna
    McKinnon, David
    Rubach, Synnøve
    The Nordic textile reuse and recycling commitment – a certification system for used textiles and textile waste2017Report (Other academic)
    Abstract [en]

    “The Nordic textile re-use and recycling commitment” certification aims to decrease the environmental impact of textile consumption and to strengthen the competitiveness of the Nordic region by increasing re-use and recycling of textile waste generated in the Nordic countries. The certification system is voluntary, and ensures sustainable and transparent handling of used textiles.

    The certification system assures that certified organizations follow strict criteria on traceability and environmental performance when collecting and handling textiles. The collected textiles will be re-used and recycled in accordance with the waste hierarchy, and all operations are reviewed by an independent third party.

    There are two types of certification. The first is for collection of textiles aimed for re-use only, and the second for collection of textiles for re-use and textile waste for recycling.

  • Vives-Cases, Carmen
    et al.
    Goicolea, Isabel
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Hernández, Alison
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Sanz-Barbero, Belen
    Davó-Blanes, MCarmen
    La Parra-Casado, Daniel
    Priorities and strategies for improving Roma women's access to primary health care services in cases on intimate partner violence: a concept mapping study2017In: International Journal for Equity in Health, ISSN 1475-9276, E-ISSN 1475-9276, Vol. 16, 96Article in journal (Refereed)
    Abstract [en]

    Background: With an explicit focus on Roma women in Spain (Kale/Spanish Gypsies), this study aims to integrate key informants' opinions about the main actions needed to improve primary health care services' and professionals' responses to Roma women in an Intimate Partner Violence (IPV) situation. Methods: Concept mapping study. A total of 50 (brainstorming phase), 36 (sorting and rating phase) and 16 (interpretation phase) participants from Roma civil society groups, primary health care professionals and other related stakeholders (social services, academic experts and other IPV NGOs representatives) from different cities in Spain were involved in the different study phases. Results: Among the 55 action proposals generated, ten priority actions were identified through consensus as most important for improving primary health care's response to Romani women in an IPV situation, and these included primary, secondary and tertiary prevention activities. Conclusion: Results indicated that efforts to address this challenge should take an integrated approach that reinforces the primary health care response to IPV in general, while also promoting more specific actions to address barriers to access that affect all Roma women and those who experience IPV in particular.

  • Aaboud, M.
    et al.
    Faculté des Sciences, Université Mohamed Premier and LPTPM, Oujda, Morocco.
    Bergeås Kuutmaan, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Maddocks, H. J.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Belanger-Champagne, Camille
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Öhman, Henrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Pelikan, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rangel Smith, Camila
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    Luminosity determination in pp collisions at root s=8 TeV using the ATLAS detector at the LHC2016In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 76, no 12, 653Article in journal (Refereed)
    Abstract [en]

    The luminosity determination for the ATLAS detector at the LHC during pp collisions at s√= 8 TeV in 2012 is presented. The evaluation of the luminosity scale is performed using several luminometers, and comparisons between these luminosity detectors are made to assess the accuracy, consistency and long-term stability of the results. A luminosity uncertainty of δL/L=±1.9% is obtained for the 22.7fb−1 of pp collision data delivered to ATLAS at s√= 8 TeV in 2012.

  • Thornadtsson, Alexandra
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Drca, Nikola
    Karolinska Inst, Dept Med; Karolinska Univ Hosp, Dept Cardiol.
    Ricciardolo, Fabio
    Univ Torino, Div Resp Dis, Dept Clin & Biol Sci, Turin, Italy..
    Högman, Marieann
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Increased levels of alveolar and airway exhaled nitric oxide in runners2017In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 122, no 2, 85-91 p.Article in journal (Refereed)
    Abstract [en]

    Aim: The objective of this study was to apply extended NO analysis for measurements of NO dynamics in the lung, divided into alveolar and airway contribution, in amateur runners and marathoners. Methods: The athletes participated in either a marathon or a half marathon. The athletes self-reported their age, weight, height, training distance per week, competing distance, cardio-pulmonary health, atopic status, and use of tobacco. Measurements of exhaled NO (FENO) with estimation of alveolar NO (CANO) and airway flux (J(aw)NO), ventilation, pulse oximetry, and peak flow were performed before, immediately after, and 1hour after completing the race. Results: At baseline the alveolar NO was higher in amateur runners, 2.91.1ppb (p=0.041), and marathoners, 3.6 +/- 1.9ppb (p=0.002), than in control subjects, 1.4 +/- 0.5ppb. J(aw)NO was higher in marathoners, 0.90 +/- 0.02 nLs(-1) (p=0.044), compared with controls, 0.36 +/- 0.02 nLs(-1), whereas the increase in amateur runners, 0.56 +/- 0.02 nLs(-1), did not attain statistical significance (p=0.165). Immediately after the race there was a decrease in FENO in both amateur runners and marathoners, whereas CANO and J(aw)NO were decreased in marathoners only. Conclusion: Our results support the view that there is an adaptation of the lung to exercise. Thus strenuous exercise increased both airway and alveolar NO, and this might in turn facilitate oxygen uptake.

  • Vladavic, Alma
    et al.
    Linköping University, Department of Social and Welfare Studies, Learning, Aesthetics, Natural science. Linköping University, Faculty of Educational Sciences.
    Simonsson, Maria
    Linköping University, Department of Social and Welfare Studies, Learning, Aesthetics, Natural science. Linköping University, Faculty of Educational Sciences.
    Ann-Marie, Markström
    Linköping University, Department of Behavioural Sciences and Learning, Education, Teaching and Learning. Linköping University, Faculty of Educational Sciences.
    Förskoleföräldrars tankar om utvecklingssamtal2017In: VENUE, ISSN 2001-788X, Vol. 7, 1-6 p.Article in journal (Other (popular science, discussion, etc.))
  • Roos, Sandra
    et al.
    Jönsson, Christina
    Posner, Stefan
    Labelling of chemicals in textiles: Nordic Textile Initiative2017Report (Other academic)
    Abstract [en]

    This report contains an analysis of the needs and barriers for a legal requirement on declaration and/or labelling of chemicals in textiles. The project is a part of the Nordic action plan for textiles ”Well dressed in a clean environment. Nordic action plan for sustainable fashion and textiles”. Based on the findings from the analysis in this report, a way forward towards a legal requirement on a declaration and/or labelling of chemicals in textiles is proposed via two main options. One option is to work for an extension of the REACH legislation: to make it applicable for labelling and declaration. This option is supported by the industry. Another option is to create a new legislation framework; a product safety regulation for textiles. This option may have a more holistic approach and can include CE-marking.

  • Verksamhetsberättelse för Svenska Institutet föt Konserveringsforskning: 1 juli 1972 - 30 juni 19731973Report (Refereed)
  • SIK:s forskningsprogram 1975/761975Report (Refereed)
  • Verksamhetsberättelse för Svenska Institutet för Konserveringsforskning: 1 juli 1974 - 30 juni 19751975Report (Refereed)
  • SIK:s forskningsprogram 1974/751974Report (Refereed)
  • Knudsen, Lisbeth E.
    et al.
    Hansen, Pernille Winton
    Workshop Report HBM4EU: Nordic workshop for scientists and regulatory agencies discussing HBM4EU - the European human biomonitoring initiative2017Report (Other academic)
    Abstract [en]

    The aim of the workshop was to bring together scientists and regulatory specialist from the Nordic countries to discuss priority setting of which substances to include in the biomonitoring programs and promote the communication between scientists and authorities regarding use of HBM data in a regulatory context (e.g. REACH). Discussions during the workshop will provide the basis for moving forward in future Nordic collaboration and contribution to HBM4EU. The prioritization of substances should be made with the concern of toxicity, exposure and persistency in mind. The substances or groups of substances that the participants find to be most important in the HBM4EU is additional metals, triclosan, nanomaterials, microplastics, poly- and perfluorinated substances, chemical UV-filters, pesticides, phosphorous containing flame retardants, organophosphates, preservatives and particles.